TWI740442B - Water-in-oil-in-water composition with multifunctionality - Google Patents

Abstract

The invention provides a water-in-oil-in-water (W/O/W) composition with multifunctionality, comprising a core layer, a middle layer covering the aforementioned core layer, and an external layer covering the aforementioned middle layer, in which the core layer including plant water extract, the middle layer includes plant oil, mineral oil and water-in-oil emulsion, and the external layer includes water-soluble polymers. The invention overcomes the problems of the storage instability and the allergenic potential of conventional WOW compositions by using specific low allergenic substances.

Description

Multifunctional water-in-oil-in-water emollient composition

The present invention relates to a water-in-oil-in-water composition, in particular to a multifunctional water-in-oil-in-water emollient composition.

There are many skin care products, including lotions, lotions, creams, essences, etc. The main functions of moisturizing, locking water, whitening and removing spots, make the skin ruddy and shiny. Different types of skin care products have different functions, but these skin care products cannot be mixed arbitrarily. Instead, they must be applied in order according to the nature of the active ingredients in the skin care products (molecular size, hydrophilicity, function, etc.) to achieve better results. The absorption effect. However, modern people have a busy life, and applying numerous skin care products in sequence is time-consuming and expensive. Therefore, it is necessary to propose a multi-effect formulation that can release different ingredients in sequence.

The water-in-oil-in-water dosage form can achieve the above-mentioned effect of sequentially releasing different ingredients. In addition, the water-in-oil-in-water dosage form can also prevent the effective substances in the core layer from contacting the air, thereby extending the shelf life. However, water-in-oil-in-water formulations are unstable when stored at room temperature. After a long period of storage, the water-soluble and fat-soluble substances dispersed in the emulsion are prone to agglomeration, which in turn leads to water-soluble and fat-soluble substances. Separation of matter. Habit formation and stability The water-in-oil-in-water formulation method can be for example: adding surfactants, adding specific ingredients in the oil phase, etc. However, the addition of these ingredients may irritate the skin and cause skin allergic reactions, which is not conducive to people with sensitive skin. .

Modern people are busy in life, not only prone to problems such as dull skin, dark spots or uneven skin tone, but also sensitive skin. Compared with normal skin, the stratum corneum of sensitive skin is thinner, so it is more fragile, not only has lower water retention, but is also more susceptible to stimulation by external stimuli, resulting in skin redness, itching and other allergic reactions. Therefore, the maintenance of sensitive skin not only needs to pay attention to moisturizing and moisturizing, but also to carefully select the ingredients of skin care products to avoid discomfort.

In view of this, it is urgent to provide a multifunctional water-in-oil-in-water emollient composition containing hypoallergenic ingredients to solve the above-mentioned problems.

Therefore, one aspect of the present invention is to provide a multifunctional water-in-oil-in-water emollient composition that can sequentially release ingredients after being applied to the skin without causing skin allergic reactions.

According to the above aspects of the present invention, a multifunctional water-in-oil-in-water emollient composition is proposed, which may include a core layer, a middle layer, and an outer layer. The core layer includes a plant water extract, which is extracted from Glycyrrhiza uralensis ), Angelica sinensis ( Angelica sinensis ), Honeysuckle ( Lonicera japonica ) and Inula japonica (Inula japonica) at least one of the ethnic group. The intermediate layer covers the aforementioned core layer, which may include vegetable fats, mineral oils, and water in oil (W/O) emulsifiers. The outer layer covers the aforementioned intermediate layer, which may include a water-soluble polymer.

According to an embodiment of the present invention, at least one of the core layer and/or the outer layer may include, but is not limited to, at least two humectants and at least two preservatives.

According to an embodiment of the present invention, the aforementioned vegetable oils are, for example, a group consisting of camellia seed oil, coconut oil, sesame oil, avocado oil, rose oil, olive oil, and any combination of the foregoing.

According to an embodiment of the present invention, the aforementioned water-soluble polymer is, for example, a group consisting of trixian gum, vegetable gum, animal gelatin, propylene polyvinyl alcohol, polyvinylpyrrolidone, acrylic polymer, and any combination of the foregoing.

According to an embodiment of the present invention, the weight ratio of the sum of the core layer and the intermediate layer to the outer layer may be, for example, 1/8 to 1/10.

According to an embodiment of the present invention, the multifunctional water-in-oil-in-water emollient composition has hypoallergenicity.

Using the multifunctional water-in-oil-in-water emollient composition of the present invention, the water-in-oil-in-water formulation stabilizes the lotion, emulsion and water-soluble active substances in the same formulation, and can be released sequentially during use , And then achieve a good emollient effect. In addition, the substances contained in the aforementioned multifunctional water-in-oil-in-water emollient composition are all hypoallergenic, and human tests have proved that they are not easy to cause allergic reactions, so they are suitable for sensitive skin.

The singular forms "a", "an" and "the" mentioned in the present invention include plural references unless the context clearly dictates otherwise. The numerical range (such as 10%~11% of A) includes the upper and lower limits (i.e. 10%≦A≦11%); if the value range does not define the lower limit (such as less than 0.2% of B, or less than 0.2% of B), it means that the lower limit may be 0 (ie 0%≦B) ≦0.2%). The above terms are used to describe and understand the present invention, but not to limit the present invention.

The present invention provides a multifunctional water-in-oil-in-water emollient composition, which has a stable water-in-oil-in-water structure, so that water-soluble substances and fat-soluble substances can be sequentially released, thereby improving the absorption of effective substances , And then strengthen the effect of emollient. The present invention can reduce the items and steps required by the conventional maintenance method, so that the subject can use a lower cost of time and money, and enjoy multiple levels of experience such as lotion, lotion, and cream. In addition, the ingredients of the above-mentioned multifunctional water-in-oil-in-water emollient composition are all hypoallergenic, so they are suitable for sensitive skin.

The multifunctional water-in-oil-in-water emollient composition of the present invention includes a core layer, a middle layer and an outer layer. In one embodiment, the core layer may include a plant water extract. The plant water extract uses water as a solvent to extract plants, so as to prevent the residue of other solvents (such as alcohol) from causing skin irritation. The extraction can be carried out, for example, by conventional methods, such as immersion, stirring, shaking, ultrasonic, water-insulating heating, microwave, or any combination of the above methods.

The plant water extract is preferably an active substance with anti-allergic and/or emollient functions, such as licorice ( Glycyrrhiza uralensis ), angelica ( Angelica sinensis ), honeysuckle ( Lonicera japonica ) and inula ( Inula japonica ) at least one of the ethnic groups. In one embodiment, the plant water extract is taken from licorice and angelica, and the weight ratio of the two can be, for example, 1 to 3, preferably 1.5 to 2.5. In one embodiment, licorice uses licorice, angelica, inula and honeysuckle, wherein the ratio of the weight of licorice and angelica to the sum of inula and honeysuckle can be, for example, 1.5 to 4, preferably 1.5 to 2.5 .

The licorice is a plant belonging to the genus Glycyrrhiza in the leguminous family, which is rich in glycyrrhizic acid and glycyrrhetinic acid (18 β-glycyrrhetinic acid) and other substances, and has soothing skin, anti-inflammatory, anti-allergic, calming and anti-allergic properties. The effect of redness. In addition, licorice also contains licorice flavonoids, which are natural whitening agents and sunscreens. In addition, the bacteriostatic substances such as glycyrrhizinol A, glycyrrhizinol B and other isoflavones in licorice also have the effect of inhibiting the biological activity of Streptococcus mutans.

The angelica is a plant belonging to Umbelliferae Angelica, which has functions of moisturizing, whitening and lightening, moisturizing the skin, antibacterial, etc., can improve the rosy degree of the skin, and can also improve skin roughness, acne, chloasma, freckles and other problems.

The honeysuckle, also known as Lonicera japonica, is a plant belonging to the genus Lonicera in the family Loniceraceae. According to records, honeysuckle has the effects of clearing heat, detoxifying and dredging the collaterals, and is often used to improve skin problems such as carbuncle, rash, spot, eczema and so on. In addition, studies have confirmed that honeysuckle has antibacterial effects and can inhibit the biological activity of viruses, bacteria and/or fungi. In some studies, honeysuckle extract can inhibit the expression and activity of tyrosinase, and has a whitening effect.

The inula is a perennial herbaceous plant of the Compositae family, which has antioxidant and whitening effects. In addition, Inula can also inhibit pathogenic bacteria such as Staphylococcus aureus, Bacillus anthracis and Shigella flexneri.

The above-mentioned plant water extracts all have a moisturizing effect. The "moisturizer" Refers to the effects of moisturizing, whitening, and increasing skin rosy. In addition, the above-mentioned plant water extract also has a bacteriostatic effect. Therefore, the addition of the above-mentioned plant water extract can also reduce the amount of preservatives, thereby reducing the possible harm of preservatives to the human body.

The plant water extract includes the dried product obtained after the plant water extract and/or the plant water extract are further subjected to water removal treatment and/or grinding treatment by a conventional method, such as freeze-dried powder. The method of the above-mentioned water removal treatment is not particularly limited, and may be, for example, a freeze-drying method, a vacuum drying method, or a spray-drying method.

The aforementioned intermediate layer covers the aforementioned core layer, and the intermediate layer may include vegetable fats, mineral oils, and water in oil (W/O) emulsifiers. The aforementioned vegetable oils have a high proportion of unsaturated fatty acids, which are helpful for skin repair and moisturizing. For example, they can be composed of camellia seed oil, coconut oil, sesame oil, avocado oil, rose oil, olive oil and any combination of the above Ethnic group. In one embodiment, camellia seed oil is used as vegetable oil. The above-mentioned mineral oil contains a high-purity mixture of a variety of alkanes and can be used as a softener, solvent and solvent. The water-in-oil emulsifier may be, for example, a conventional water-in-oil emulsifier. In one embodiment, the water-in-oil emulsifier can be selected from, for example, PEG-30 dipolyhydroxystearate (Dipolyhydroxystearate), glyceryl oleate (Glyceryl oleate), polyglycerol-3 polyricinoleate ( Polyglyceryl-3 polyricinoleate), Olea europaea and any combination of the above groups.

The outer layer covers the intermediate layer, and the outer layer may include a water-soluble polymer. The above-mentioned water-soluble polymer is not particularly limited, and it can be made of, for example, Sanxian gum, Plant gum, animal gelatin, propylene polyvinyl alcohol, polyvinylpyrrolidone, acrylic polymer and any combination of the above groups.

Generally speaking, the weight ratio of the sum of the core layer and the middle layer to the outer layer is not particularly limited. In an embodiment, the weight ratio of the sum of the core layer and the intermediate layer to the outer layer may be, for example, 1/8 to 1/10, preferably 1/9. It is explained here that if the weight ratio of the sum of the core layer and the middle layer to the outer layer falls within the above range, it will provide a refreshing and not sticky feeling.

At least one of the core layer and/or the outer layer includes at least two humectants and at least two preservatives. The humectant may include, but is not limited to, hyaluronic acid, ceramide, 1,2-propanediol, 1,3-butanediol, sorbitol, and/or glycerin. Preservatives may include, but are not limited to, polyols such as Pentylene glycol, 1,2-Hexanediol, 1,2-Caprylyl glycol, and/or ethylhexyl Ethylhexyl glycerin.

One of the technical features of the present invention is to form an oil-in-water-in-water dosage form, which can coat and stabilize the active substance in the core layer, thereby achieving an emollient effect. In addition, the oil-in-water-in-water dosage form of the present invention uses hypoallergenic ingredients, which can overcome the instability of the oil-in-water-in-water dosage form or possible allergic reactions. It is explained here that if the above-mentioned specific ingredients are used in the core layer, the middle layer and the outer layer, the multifunctional water-in-oil-in-water emollient composition of the present invention will have lower allergenicity and higher stability. In one embodiment, the above-mentioned multifunctional water-in-oil-in-water emollient composition can be stored at room temperature for more than half a year without delamination.

The "hypoallergenic" means that after contact with skin, it does not cause skin The nature of immediate allergic reactions. In detail, the immediateness is within 30 minutes after contact with the skin. The allergic reaction includes symptoms such as skin redness, swelling, papules and/or blisters. The skin may be normal skin or sensitive skin.

Several embodiments are used below to illustrate the application of the present invention, but they are not used to limit the present invention. Those with ordinary knowledge in the technical field of the present invention can make various modifications and changes without departing from the spirit and scope of the present invention. Retouch.

1. Preparation of multifunctional water-in-oil-in-water emollient composition

Preparation Example 1:

Licorice, angelica, inula and honeysuckle are extracted, followed by drying and grinding to obtain the powder of plant water extracts such as licorice, angelica, inula and honeysuckle, respectively. Next, mix the core layer raw materials, which include 0.20 parts by weight of the above-mentioned licorice water extract, 0.08 parts by weight of the above-mentioned angelica water extract, 0.09 parts by weight of the inula flower water extract, 0.03 parts by weight of the honeysuckle water extract, 5.00 parts by weight of 1% hyaluronic acid, 1.00 parts by weight of ceramide-containing composition [product name: CareSkin O, manufactured by Yuzhi Biochemical Technology Co., Ltd., International Nomenclature of Cosmetic Ingredients (INCI) name: Isostearyl alcohol and Ceramide 3] and 81.80 parts by weight of water.

The intermediate layer raw materials are mixed, wherein the intermediate layer raw materials include 1.00 parts by weight of camellia seed oil, 2.00 parts by weight of mineral oil, and 1.00 parts by weight of squalane composition [Product name: Plantasens® Olive Squalane, Clariant Chemical Co., Ltd., INCI name: Squalane] and 6.00 parts by weight of W/O type emulsifier composition [Product name: Plantasens® Natural Emulsifier CP5, Clariant Chemical Co., Ltd., INCI name: Glyceryl Oleate, Polyglyceryl -3-polyricinoleate, Olea Europaea (Olive) Oil Unsaponifiables].

Mixed alcohol raw materials, where the alcohol raw materials contain 1.00 parts by weight of pentanediol and 0.80 parts by weight of polyol composition [Product name: Dermosoft® MCA Variante, manufactured by Evonik Dr. Straetmans, INCI name: Caprylyl glycol, Glyceryl caprylate and Dipropylene glycol ].

The above-mentioned core layer raw materials, intermediate layer raw materials and alcohol raw materials are mixed to form a total of 100 parts by weight of the core layer and the intermediate layer.

Then mix the outer layer raw materials, wherein the outer layer raw materials include 0.8 parts by weight of Sanxian gum, 5.00 parts by weight of sorbitol, 3.00 parts by weight of glycerin, 1.00 parts by weight of pentanediol, and 90.2 parts by weight of water.

The sum of the core layer and the middle layer and the outer layer are mixed, and the weight ratio of the sum of the core layer and the middle layer to the outer layer is 1/9. Then, after adding an appropriate amount of triethanolamine to adjust the pH to pH 6, a multifunctional water-in-oil-in-water emollient composition is obtained.

Preparation Example 2:

The method, materials, and ratio are the same as those in Preparation Example 1, with the difference that the weight parts of licorice water extract, angelica water extract, inula water extract, and honeysuckle water extract are 0.16, 0.1, 0.07, and 0.07, respectively.

2. Evaluation of multifunctional water-in-oil-in-water emollient composition

The multifunctional water-in-oil-in-water emollient composition of Preparation Example 1 and Preparation Example 2 was applied to the skin of subjects to evaluate skin allergic reaction and skin moisturization. The evaluation of skin moisturization was based on the skin surface layer containing Water volume and trans-epidermal water loss (TEWL) are used as indicators.

First, conduct an assessment of skin allergic reactions. Before the assessment, first use a questionnaire to investigate whether the subject has skin allergies or skin disease history to find out whether the subject has sensitive skin. Next, apply the multifunctional water-in-oil-in-water emollient composition to the skin of the inner arm of the subject. After 30 minutes, observe whether the skin has redness, swelling, papules, blisters and other allergic reactions to determine whether allergic reactions have occurred. . In this example, 2 of the 6 subjects have sensitive skin, but no matter whether they have sensitive skin or not, none of the subjects had allergic reactions in this evaluation test.

Next, perform skin moisturization evaluation, which uses a commercially available instrument to detect the moisture content of the skin surface layer before use and after use (ie 30 minutes after applying the multifunctional water-in-oil-in-water emollient composition) and TEWL , Wherein the water content and TEWL were measured with the Corneometer CM 825 and Tewameter TM 300 made by Courage+Khazaka electronic GmbH, Germany.

Next, the multifunctional water-in-oil-in-water emollient composition of Preparation Example 1 was applied to the subject’s skin for 30 minutes, and then the hands were tested with the same instrument. The water content and TEWL of the skin on the inner side of the arm are shown in Table 1 and Table 2, respectively. The water content of the skin surface layer is expressed in an instrument-specific unit (arbitrary unit; au), and TEWL is expressed per unit time per unit The evaporation weight of the skin area is expressed.

Among the 6 subjects, 2 subjects (No. 5 and No. 6) had sensitive skin, and the other subjects had normal skin. As shown in Table 1 and Table 2, after 30 minutes of application, the skin surface water content of subjects with normal skin types increased, and TEWL decreased, indicating that the multifunctional water-in-oil-in-water emollient composition of this example can be used Replenish the moisture of general skin and increase its ability to retain moisture. For subjects with sensitive skin, after 30 minutes of application, the water content of the skin surface layer increased greatly, indicating that the multifunctional water-in-oil-in-water emollient composition of the present invention can moisturize sensitive skin.

It can be seen from the above embodiments that the application of the multifunctional water-in-oil-in-water emollient composition of the present invention can stabilize the structure of the water-in-oil-in-water and release water-soluble substances, fat-soluble substances and plants in sequence during application. The water extract is equivalent to applying lotion, lotion and cream in sequence, which can increase the absorption rate of effective substances and achieve better emollient effect. In addition, the components of the multifunctional water-in-oil-in-water emollient composition of the present invention are hypoallergenic, so it is suitable for sensitive skin.

It should be added that although the present invention uses specific ingredients and/or test methods as examples to illustrate the moisturizing effect of the multifunctional water-in-oil-in-water emollient composition of the present invention, anyone in the technical field of the present invention has general knowledge It can be understood that the present invention is not limited to this. Without departing from the spirit and scope of the present invention, the multifunctional water-in-oil-in-water emollient composition of the present invention can also be carried out using other ingredients and/or test methods.

Although the present invention has been disclosed in several embodiments as above, it is not intended to limit the present invention. Anyone with ordinary knowledge in the technical field of the present invention can make various changes without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be subject to the scope of the attached patent application.

Claims (5)

A multifunctional water-in-oil-in-water emollient composition, comprising: a core layer comprising a plant water extract, wherein the plant water extract is composed of licorice ( Glycyrrhiza uralensis ) water extract and angelica ( Angelica sinensis ) water extract It consists of honeysuckle ( Lonicera japonica ) water extract and Inula japonica (Inula japonica) water extract, wherein the licorice water extract: the angelica water extract: the honeysuckle water extract: the inula japonica water The weight ratio of one of the extracts is 20:8:3:9, and the weight ratio of the sum of the core layer and the intermediate layer to the weight of the outer layer is 1/8 to 1/10; and an intermediate layer covering the A core layer, wherein the middle layer includes a vegetable oil, a mineral oil, and a water-in-oil (W/O) emulsifier; and an outer layer covering the middle layer, wherein the outer layer includes a water-soluble polymer, And the multifunctional water-in-oil-in-water emollient composition has hypoallergenicity to a subject with sensitive skin. The multifunctional water-in-oil-in-water emollient composition as claimed in Patent Application 1, wherein at least one of the core layer and/or the outer layer includes at least two humectants and at least two preservatives. The multifunctional water-in-oil-in-water emollient composition as described in the scope of patent application 1, wherein the vegetable oil is composed of camellia seed oil, coconut oil, sesame oil, avocado oil, rose oil, olive oil and any combination of the foregoing It is an ethnic group. The multifunctional water-in-oil-in-water emollient composition as described in the scope of patent application 1, wherein the water-soluble polymer is composed of trixian gum, vegetable gum, animal gelatin, propylene polyvinyl alcohol, polyvinylpyrrolidone, and acrylic acid A group of polymers and any combination of the above. Use of a multifunctional water-in-oil-in-water emollient composition for manufacturing hypoallergenic compositions, wherein the multifunctional water-in-oil-in-water emollient composition is as described in claim 1 to claim 4 And the multifunctional water-in-oil-in-water emollient composition has hypoallergenicity to a subject with sensitive skin.