TWI660751B - Patch - Google Patents

Abstract

The adhesive of the present invention has a support and an adhesive layer laminated on the support, and the adhesive layer, based on the total mass of the adhesive layer, contains 0.01 mass% to 0.026 mass% of nonanoic acid vanilla tincture. Amine and 0.85 mass% to 3 mass% of cork powder, the mass ratio of vanillyl nonanoate to cork powder is 1: 42.5 to 1: 170. Such a patch does not easily produce an unpleasant odor even if it is stuck for a long time.

Description

Patch

The present invention relates to a patch.

Thermo-sensitive anti-inflammatory analgesic patches containing a thermo-sensitive stimulant are known. Warm-sensitive anti-inflammatory and analgesic patches are mostly used to treat or relieve symptoms such as periarthritis, low back pain, and muscle pain by improving blood flow at the site of application. As a temperature-sensitive stimulant, a pepper extract component (capsaicins) and vanillin nonanoate (for example, Patent Document 1) are used. [Prior Art Document] [Patent Document] Patent Document 1: Japanese Patent Laid-Open No. 2008-179564

[Problems to be Solved by the Invention] The present inventors have found that an unpleasant odor may be generated in a patch containing vanillin nonanoate due to long-term sticking. An object of the present invention is to provide an adhesive agent that does not easily produce an unpleasant odor even if it is attached for a long time. [Technical means to solve the problem] The present inventors have found that if the cork powder is blended in the adhesive layer, the generation of unpleasant odor caused by vanillin nonanoate can be suppressed, and the present invention has been completed. That is, the present invention provides an adhesive agent, which has a support and an adhesive layer laminated on the support, and the adhesive layer contains 0.01% by mass to 0.026% by mass based on the total mass of the adhesive layer. Vanillyl nonanoate and 0.85 mass% to 3 mass% of cork powder, the mass ratio of vanillyl nonanoate to cork powder is 1: 42.5 to 1: 170, preferably 1: 42.5 to 1: 150. The adhesive layer may contain an anti-inflammatory analgesic. The adhesive layer may contain one or more adhesive bases selected from the group consisting of rubber-based adhesive bases, acrylic-based adhesive bases, and polysiloxane-based adhesive bases, and may also contain styrene-isoprene-benzene. Ethylene block copolymer, polyisobutylene and terpene resin. [Effects of the Invention] The present invention can provide an adhesive agent that does not easily produce an unpleasant odor even if it is stuck for a long time.

The adhesive of this embodiment has a support and an adhesive layer laminated on the support. The support system physically supports the layers of the adhesive layer. The material of the support is not limited as long as it is a general user in the patch. Examples include polyolefins such as polyethylene, polypropylene, and polybutadiene; polyethylene terephthalate, and polyterephthalate. Polyesters such as butane dicarboxylate, polyethylene naphthalate; and ethylene-vinyl acetate copolymers, vinyl acetate-vinyl chloride copolymers, polyvinyl chloride, polyamide, nylon, cellulose derivatives, Synthetic resins such as polyurethane. The properties of the support may be a film, a sheet, a sheet-like porous body, a sheet-like foam, a woven fabric, a knitted fabric, a non-woven fabric, or a laminate thereof. Since a nonwoven fabric is excellent in stretchability, it is preferable from a viewpoint of skin adhesion. The adhesive layer contains vanillyl nonanoate and cork powder. The content of vanillyl nonanoate is 0.01 mass% to 0.026 mass%, preferably 0.02 mass% to 0.024 mass%, based on the total mass of the adhesive layer. The content of the cork powder is 0.85 mass% to 3 mass% based on the total mass of the adhesive layer. The mass ratio of vanillyl nonanoate to cork powder is 1: 42.5 to 1: 170, and preferably 1: 42.5 to 1: 150. By setting the content of vanillyl nonanoate within the above range, itchy sensation can be suppressed and moderate warm stimulus can be given to the skin. In addition, by setting the content of cork powder to the above range and setting the mass ratio of vanillyl nonanoate and cork powder within the above range, the unpleasant odor caused by vanillyl nonanoate can be suppressed. To produce. From the viewpoint of suppressing the itchiness of the skin, the content of vanillin nonanoate is preferably 0.018 mass% to 0.026 mass%. From the viewpoint of further reducing skin reactions, the content of the cork powder is preferably 1.7% to 3% by mass based on the total mass of the adhesive layer. From the same point of view, the mass ratio of vanillyl nonanoate to cork powder is more preferably 1: 70.9 ~ 1: 150 or 1: 85.1 ~ 1: 150. In addition, the cork is obtained by removing the bark of the bark of Phellodendron amurense Ruprecht or Phellodendronchinense Schneider (Rutaceae), and the powder of cork is made of cork. Regarding the mechanism by which the cork powder produces an effect of suppressing the generation of unpleasant odors, the present inventors and others have speculated as follows. Promotes perspiration at the attachment site with vanillyl nonanoate which is included in the patch. Sweat tends to stay between the skin and the patch, and bacteria such as skin resident bacteria multiply due to the sweat and produce an unpleasant odor. Cork powder inhibits the generation of unpleasant odors by inhibiting the proliferation of bacteria, or by adsorbing, inactivating or masking odor components.

In addition to vanillyl nonanoate and cork powder, the adhesive layer may contain an adhesive base, a drug, and other ingredients (tackifier resin, plasticizer, filler, stabilizer, percutaneous absorption enhancer for drugs, perfume, Colorants, ingredients that relieve skin irritation caused by drugs, etc.). From the viewpoints of adhesion and moderate temperature stimulus, the adhesive layer is preferably a non-aqueous system (for example, the moisture content is 5% or less based on the total mass of the adhesive layer).

The adhesive base is not limited as long as it is a general user in the patch, and examples thereof include a rubber-based adhesive base, an acrylic-based adhesive base, and a silicone-based adhesive base.

The rubber-based adhesive base can be a polymer with natural or synthetic rubber as the main body, such as polyisoprene, polyisobutylene, polybutadiene, styrene-isoprene-styrene block copolymer (SIS Block copolymer), styrene-butadiene-styrene block copolymer, styrene-butadiene rubber or styrene-isoprene rubber. Examples of the acrylic adhesive base include a polymer of an alkyl (meth) acrylate or a copolymer of an alkyl (meth) acrylate and a comonomer. Here, the alkyl (meth) acrylate means an alkyl acrylate and an alkyl methacrylate. Examples of the alkyl (meth) acrylate include butyl (meth) acrylate, isobutyl (meth) acrylate, hexyl (meth) acrylate, octyl (meth) acrylate, and (meth) ) 2-ethylhexyl acrylate and decyl (meth) acrylate. The alkyl (meth) acrylate can be used alone or in combination of two or more. Examples of the comonomer include hydroxyalkyl (meth) acrylate, ethylene, propylene, styrene, vinyl acetate, N-vinylpyrrolidone, and (meth) acrylamide. A comonomer can be used individually or in combination of 2 or more types. Specific examples of the acrylic adhesive base include those containing a copolymer selected from butyl acrylate, 2-ethylhexyl acrylate, vinyl acetate, methacrylic acid, hydroxyethyl acrylate, and methyl. At least two kinds of glycidyl acrylate, methoxyethyl acrylate, and acrylic acid, and more specifically, DURO-TAK 87-2097, 87-2194, 87-2196, 87-2287, 87-2516, and 87-2852 (trade name, Henkel); and Nissetsu KP-77 and AS-370 (trade name, Japan Calcium Carbide Industry Co., Ltd.). Examples of the polysiloxane-based adhesive base include organic polysiloxanes such as a dimethyl polysiloxane, a condensation reaction product of dimethyl polysiloxane and a silicate resin. Specific examples of the silicone adhesive base include BIO-PSA X7-4201, BIO-PSA Q7-4501, 360 Medical fluid 1000CS, and MDX4-4210 of Dow Corning Corporation. The drug is not limited as long as it has a therapeutic effect on the subject for transdermal absorption, and examples include the following anti-inflammatory analgesics: acetaminophen, phenacetin, mefenamic acid, diclofenac sodium, flufenamic acid , Aspirin, sodium salicylate, methyl salicylate, glycol salicylate, aminopyroline, aclofenac, ibuprofen, naproxen, flurbiprofen, ketoprofen, ammonia Sodium fenofen, thiapyrazole, indomethacin, piroxicam, losoprofen, tiprofen, asimicin, biphenylacetic acid, sulindac, etodolac, tolmetin, amphetamine Xikang, Azabin, Vardecoxib, Rofecoxib, etc. Examples of the tackifying resin include terpene resins, terpene phenol resins, rosin ester resins, hydrogenated rosin ester resins, alicyclic saturated hydrocarbon resins, and petroleum resins. From the viewpoint of rapidly generating a thermal stimulus, the tackifier resin is preferably a terpene resin. The terpene resin may or may not be hydrogenated, and is preferably a hydrogenated terpene resin. Examples of the terpene resin include α-pinene resin, β-pinene resin, aromatic modified terpene resin, and terpene phenol resin. Examples of the plasticizer include paraffin oil (liquid paraffin, etc.); squalane, squalene, vegetable oils (olive oil, camellia oil, castor oil, tall oil, peanut oil, green mint oil, eucalyptus oil) , Jojoba oil, camphor oil, sunflower oil, sweet orange oil, etc.); oils (dibutyl phthalate, dioctyl phthalate, etc.); and liquid rubber (liquid polybutylene Ene, liquid isoprene rubber, etc.). Examples of the filler include metal compounds (alumina, aluminum hydroxide, zinc oxide, titanium oxide, calcium carbonate, etc.), ceramics (talc, clay, kaolin, silicon dioxide, hydroxyapatite, and synthetic aluminum silicate). , Magnesium magnesium metasilicate, etc.) or organic compounds (cellulose powder, stearate, etc.) powder or short fibers containing these resins. Examples of the ingredients that alleviate skin irritation caused by drugs include water-absorbing compounds such as acrylic starch, functional resins, surfactants, and cold-sensing ingredients (menthol, 3-L-mentholoxypropane-1,2 -Diols and antipruritic ingredients (cromiton, antihistamines (diphenhydramine, clofeniramine, isopropyl 𠯤 etc.), etc.) Regarding the adhesive layer, it partially replaces nonan A thermosensory ingredient formulated with vanillin, that is, a compound that acts on the temperature receptor family of the TRP (Transient Receptor Potential) channel. For example, it may contain piperine, kaempferol, and gingerol (Gingerol). ), Ginger oil, allyl isothiocyanate (spicy ingredients such as mustard and mandrill), camphor, ruvanol, eugenol, carvacrol, cinnamaldehyde, or benzyl nicotinate. In addition to the above In addition to components, the adhesive layer may contain inorganic or organic components (e.g., acids such as citric acid or bases such as sodium hydroxide), salts such as sodium chloride, amines (triethanolamine, triethylamine, etc.) or Chelating agents (ascorbic acid, ethylenediaminetetraacetic acid, etc.). On the opposite side of the support, there is a release liner on the surface in contact with the skin. The release liner is a liner that is removed when using an adhesive, and it is not limited as long as it is a general user of the adhesive. As a peel The material of the liner includes polyester (polyethylene terephthalate (PET), etc.), polyolefin (polypropylene, polyethylene, etc.), and cellulose compounds (paper, etc.). The release liner may include The sheet shape of the above-mentioned laminated body. The surface of the release liner is preferably demoulded with silicone or fluorinated polyolefin. The adhesive of this embodiment can be produced, for example, by the following method. 1) The components of the adhesive layer are weighed, and if necessary, heating and solvent addition are performed, and they are mixed for homogenization. 2) The obtained adhesive composition is coated on the release surface of the release liner with a certain thickness, and if necessary, dried to remove the solvent component to form an adhesive layer. 3) A support is laminated on the adhesive layer. 4) Cut into a specific shape (for example, a rectangle with a short side of 3 cm to 14 cm and a long side of 7 cm to 20 cm, or a circle with a diameter of 1 cm to 5 cm). [Examples] Test Example 1: Evaluation of Thermal Sensation Each component was weighed according to the composition in Table 1, and was melted and mixed by heating to obtain an adhesive composition. The release agent-containing release liner including a PET film was coated with an adhesive composition so as to have a thickness of about 320 μm. A support comprising a PET nonwoven is laminated on top of the layer of the adhesive composition. This laminated body was cut into a circular shape having a diameter of 2.5 cm, and the adhesives of Comparative Examples 1 to 2 and Examples 1 to 16 were obtained. In Table 1, nonanoic acid VA represents vanillyl nonanoate, and SIS represents a styrene-isoprene-styrene block copolymer. Other ingredients are fillers and the like. [Table 1] The strength of the thermal stimulus of each patch was evaluated by a functional test (n = 60 to 105). Specifically, one patch was affixed to the subject's shoulder, and the intensity of the thermal stimulus 1 hour after the application was scored according to the following criteria to calculate the average value. Temperature stimulus is too strong ... 100 Temperature stimulus is strong ... 80 Moderate intensity of temperature stimulus ... 60 Temperature sensation is weak ... 40 Temperature sensation is too weak ... 20 No temperature stimulus ... 0 By functional test (n = 60 to 105) The strength of the itchiness of each patch was evaluated. Specifically, one patch was affixed to the subject's shoulder, and the intensity of the itchiness after 4 hours of application was scored according to the following criteria to calculate the average value. I feel very strong itching and can't tolerate it ... 100 I feel very strong itching, which is the limit of tolerance ... 80 I feel strong itching ... 60 I obviously feel itching ... 40 I feel itching ... 20 Slightly feeling Itching, not too concerned ... 15 I felt a small itching, almost didn't care ... 10 I felt a very small itching, I didn't care at all ... 5 I didn't feel an itching ... 0 Comparative Example 1, Examples 1 to 8 The test results of the patch are summarized in Tables 2 and 3. [Table 2] [table 3] As shown by the results shown in Table 2, if the content of vanillyl nonanoate is 0.01% by mass or more, the intensity of the thermal stimulus is moderate. Although the results are not shown in the table, if the content of vanillyl nonanoate is 0.03% by mass or more, the warm sensation of the patch is too strong, so the skin is hot and the use of the patch is not satisfactory. According to the results shown in Table 3, it is surprising that the more the vanillyl nonanoate content, the weaker the itchy skin caused by the patch. The vanillyl nonanoate content is 0.01. When the content is at least% by mass, the itchiness is barely noticeable. The adhesives of Examples 9 to 16 are those in which the content of SIS in the adhesives of Examples 1, 3, 5, and 8 was changed, but the test results of the intensity of the warm stimulus and itching are the same as those of Example 1 The same evaluation was made for the patches of 3, 5 and 8. This suggests that the strength of the warm stimulus and itching is not easily affected by the composition of the adhesive base. Test Example 2: Evaluation of the unpleasant odor suppressing effect and skin reaction. Each component was weighed according to the composition in Table 4, and melted and mixed by heating to obtain an adhesive composition. The release agent-containing release liner including a PET film was coated with an adhesive composition so as to have a thickness of about 320 μm. A support comprising a PET nonwoven is laminated on top of the layer of the adhesive composition. This laminated body was cut into a circular shape having a diameter of 2.5 cm, and the adhesives of Comparative Examples 3 to 6 and Examples 17 to 21 were obtained. Furthermore, DURO-TAK 87-2097 was used as the acrylic adhesive base, and BIO-PSA X7-4201 was used as the polysiloxane adhesive base. [Table 4] The unpleasant odor strength of the above-mentioned patch and the patch of Test Example 1 were evaluated by a functional test (n = 6). One patch was applied to the forearm or upper arm of the subject, and the patch was peeled off after 8 hours. The skin odor emitted from the application site was scored according to the following criteria, and the average value was calculated. Unpleasant odor was felt ... 2 Unpleasant odor was slightly felt ... 1 Unpleasant odor was not felt ... 0 The applicability of the above-mentioned patch and Test Example 1 were evaluated by a functional test (n = 6) The strength of the skin reaction of the agent. One patch was applied to the forearm or upper arm of the subject, and the patch was peeled off after 8 hours. The intensity of the skin reaction (swelling and redness) at the application site was scored according to the following criteria, and the average value was calculated. Puffiness appears ... 3 Significant redness ... 2 Slight redness ... 1 No redness ... 0 The test results (intensity of unpleasant odor) of the patches of Comparative Examples 3 to 4 and Examples 17 to 19 are summarized in the table 5. [table 5] As shown by the results shown in Table 5, as the content of the cork powder becomes higher, the unpleasant odor tends to weaken. Especially when the content of cork powder is 0.85 mass% or more and the ratio of vanillyl nonanoate: cork powder is 1: 42.5 or more, the generation of unpleasant odors is completely suppressed. Although the results are not shown in the table, even if the patch had a vanillyl nonanoate content of 0.01% by mass and a cork powder content of 0.85% by mass (the ratio of the two was 1:85), the order was suppressed. The generation of unpleasant smells. The test results (intensity of unpleasant odor) of the adhesives of Examples 5, 7, 20 to 21, and Comparative Example 2 are summarized in Table 6. [TABLE 6] As shown by the results shown in Table 6, the generation of unpleasant odor was suppressed in any of the patches. As is known from the results of Examples 20 to 21, even if an adhesive agent using an acrylic adhesive base or a silicone adhesive base as the adhesive base, the generation of unpleasant odors was suppressed. The adhesives of Examples 13 to 14 and Comparative Examples 5 to 6 are those in which the content of SIS in the adhesives of Examples 5 and 2 was changed, but the test results of the unpleasant odor intensity The evaluations were the same as those of the adhesives of Example 5 and Comparative Example 2. This suggests that the effect of suppressing the production of unpleasant odors is not easily affected by the composition of the adhesive base. The test results (skin reactions) of the patches of Examples 5, 7, 17, 18 and Comparative Examples 2 to 4 are summarized in Table 7. [TABLE 7] As shown by the results shown in Table 7, as the content of the cork powder becomes higher, the skin reaction tends to decrease.

Claims (7)

An adhesive agent comprising a support and an adhesive layer laminated on the support, and the adhesive layer is based on the total mass of the adhesive layer and contains 0.01 mass% to 0.026 mass% of nonanoic acid vanilla tincture. Amine and 0.85 mass% to 3 mass% of cork powder. The mass ratio of vanillyl nonanoate to cork powder is 1: 42.5 to 1: 170. As in the patch of claim 1, the mass ratio of vanillyl nonanoate to cork powder is 1: 42.5 ~ 1: 150. The patch of claim 1 or 2, wherein the adhesive layer contains an anti-inflammatory analgesic. For example, the adhesive of claim 1 or 2, wherein the adhesive layer contains one or more adhesive bases selected from the group consisting of rubber-based adhesive bases, acrylic-based adhesive bases, and polysiloxane-based adhesive bases. The adhesive according to claim 1 or 2, wherein the adhesive layer contains a styrene-isoprene-styrene block copolymer, polyisobutylene, and a terpene resin. The adhesive according to claim 3, wherein the adhesive layer contains one or more adhesive bases selected from the group consisting of rubber-based adhesive bases, acrylic-based adhesive bases, and silicone-based adhesive bases. The adhesive of claim 3, wherein the adhesive layer contains a styrene-isoprene-styrene block copolymer, polyisobutylene, and a terpene resin.