TWI649066B - Method and device for optically detecting and evaluating therapeutic effect of Kawasaki disease - Google Patents

Abstract

The invention relates to a method and a device for optically detecting and evaluating the therapeutic effect of Kawasaki disease. Three or more wavelengths of light are respectively passed through a healthy test subject and a Kawasaki disease (or suspected patient) to be detected, and the three are absorbed by the tissue of the site to be detected and the intensity is attenuated. More than one light wave, according to the attenuation state of the three or more light waves, the absorption spectrum of the human tissue, the hemoglobin content and the moisture content of the healthy subject and the Kawasaki disease (or suspected patient) to be detected . Comparing the hemoglobin content and the moisture content of the site to be detected of the Kawasaki disease patient (or suspected patient) with the hemoglobin content and the moisture content of the healthy subject to be detected to obtain the difference therebetween, Based on these two values and their clinical experience, medical staff assess the therapeutic effect of Kawasaki (or whether or not they suffer from Kawasaki disease).

Description

Method and device for optically detecting and evaluating therapeutic effect of Kawasaki disease

The invention relates to a method and a device for optically detecting and evaluating the therapeutic effect of Kawasaki disease, in particular to detecting the moisture (swelling) and hemoglobin (redness phenomenon) of the limbs of a sick child by using a non-invasive optical detection method. And the blood oxygen concentration is used by the physician to judge the therapeutic effect of Kawasaki disease or whether or not to suffer from Kawasaki disease based on the above numerical values and clinical experience.

Kawasaki disease occurs in children under the age of five, mainly in the form of systemic vasculitis, and has become the main culprit in children with acquired heart disease in developed countries. The conditions for diagnosing Kawasaki disease are four of the following five conditions, including: conjunctivitis, strawberry tongue or chapped lips, generalized skin rash, swelling of the hands and feet, peeling and neck lymphadenopathy, plus persistent fever greater than or equal to Five days to confirm the diagnosis.

At present, it is possible to assist physicians in judging whether a young child is suffering from Kawasaki disease, or a method that can assist a physician in judging the therapeutic effect of Kawasaki disease after Kawasaki disease has been treated. Most of the above methods are invasive. For example, Republic of China Patent No. 201028480 "Detection methods and applications of unhealthy cells"

However, invasive testing can cause fear and discomfort for young children, and invasive testing generally involves more or less risk of infection.

Swelling at the extremities is quite common in Kawasaki disease. It is one of the five major symptoms of Kawasaki disease. According to our findings, about 90% of sick children will develop this symptom, which is second only to conjunctivitis. Our study also found that albumin (albumin) is reduced, and the degree of reduction is related to the severity of the disease. There is a clear positive correlation, so we develop a Kawasaki disease optical detection method that can detect moisture (swelling), hemoglobin (redness) and blood oxygen based on this theoretical basis, and provide practical values to improve the doctor's judgment on whether young children are suffering from it. The correct rate of Kawasaki disease, and this optical detection method can be further used as a basis for evaluating the therapeutic effect of Kawasaki disease.

Therefore, the present invention provides a Kawasaki disease optical detection method comprising the following steps: A. Passing at least three light waves of different wavelengths through a to-be-detected portion of a healthy subject and receiving tissue absorption by the site to be detected. And the three or more light waves whose intensity is attenuated are obtained according to the attenuation state of the three or more light waves, and the hemoglobin content and the moisture content of the part to be detected of the healthy subject are obtained; B. Utilization and A In the same manner, a part of the suspected patient is detected, and three or more light waves of the intensity attenuation are obtained, and the hemoglobin content and the moisture content of the suspected part to be detected are further obtained; A processor compares the hemoglobin content and the moisture content of the suspected part to be detected with the hemoglobin content and the moisture content of the healthy subject to be detected, and compares the two values Output.

The invention further provides a method for optically evaluating the therapeutic effect of Kawasaki disease, comprising the following steps: A. passing at least three light waves of different wavelengths through a to-be-detected part of a healthy subject, and receiving the received The three or more light waves that are absorbed by the tissue at the detection site and whose intensity is attenuated are obtained according to the attenuation state of the three or more light waves than the absorption spectrum of the human tissue, and the hemoglobin content and the moisture content of the healthy subject to be detected are obtained; B. Using the same method as step A to detect a site to be detected in a Kawasaki disease patient, and obtain three or more light waves of the intensity attenuation, and further obtain the heme content and moisture content of the Kawasaki disease patient to be detected. C. A processor compares the hemoglobin content and the moisture content of the Kawasaki disease patient to the hemoglobin content and the moisture content of the healthy subject to be detected, and outputs the comparison result.

The invention further provides a detecting device for performing the Kawasaki disease optical detecting method as described above, comprising: detecting a light source to emit at least three light waves of different wavelengths; and an optical receiver for receiving the light wave after the attenuation intensity. The processor signal is connected to the detecting light source and the light receiver for operating the detecting light source and the light receiving device to receive the to-be-detected part of the healthy subject and the suspected part to be detected The hemoglobin content and the moisture content are then compared with the hemoglobin content and the moisture content of the healthy test subject to be tested and the suspected patient's to-be-tested site.

According to the above technical features, the following effects can be achieved:

1. The present invention provides a non-invasive method that can clinically assist physicians in early diagnosis of Kawasaki disease. Assist the physician or parent to make a correct diagnosis within five to ten days of the child's fever, and successfully allow the child to receive high-dose immunoglobulin therapy, so as to significantly reduce the risk of Kawasaki's damage to the child's heart, as soon as possible and Immediate diagnosis is the most important key to the treatment of this disease.

2. The present invention utilizes an optical detection system for detecting hemoglobin content, moisture content, and blood oxygen concentration in limb tissues to evaluate the symptoms of Kawasaki disease, and it is completely unnecessary to collect blood samples of the sick child, and is completely non-invasive. The way to create a new diagnostic tool for Kawasaki disease, and to provide very good sensitivity and specificity.

3. By developing the optical detecting device of the present invention, the Kawasaki disease detecting method according to the present invention is implemented, commercialized and popularized, so that all doctors or even parents can diagnose and treat this trick more efficiently and accurately. Kawasaki disease, and save more children's precious lives, so that the future of the country is full of hope and vitality.

4. The present invention utilizes an optical detection system for detecting hemoglobin content, moisture content, and blood oxygen concentration in limb tissues, which can be further used as a basis for evaluating the therapeutic effect of Kawasaki disease.

5. The present invention further combines the hemoglobin and moisture content in the extremity tissue obtained by optical detection with a neural network algorithm, thereby deducing the correct classification of Kawasaki disease symptoms and providing a more suitable mode for clinical application.

(1)‧‧‧Detecting light source

(11)‧‧‧First light source

(12)‧‧‧second light source

(13)‧‧‧ Third light source

(2) ‧‧‧Optical Receiver

(3) ‧‧‧ processor

(4) ‧‧‧Control devices

[First figure] is a schematic view of the detecting device of the present invention.

[Second figure] is a functional block diagram of the detecting device of the present invention when it is used.

[Third Figure] is a flow chart of the detection method of the present invention.

[Fourth figure] is a comparison chart of the attenuation light intensity after the first light wave to the third light wave are absorbed by the healthy subject and the tissue of the suspected patient according to the present invention.

[Fifth A] is the evaluation of the Kawasaki disease treatment effect in the general control group (health group), fever control group, Kawasaki disease treatment, Kawasaki disease treatment, before discharge, and Kawasaki disease treatment for at least three weeks. Comparison of oxyhemoglobin.

[Fifth B] is the evaluation of Kawasaki disease treatment in the general control group (health group), fever control group, Kawasaki disease treatment, Kawasaki disease treatment, before discharge, and Kawasaki disease treatment for at least three weeks. Comparison of hemoglobin.

[Fifth C] is the evaluation of Kawasaki disease treatment in the general control group (health group), fever control group, Kawasaki disease treatment, Kawasaki disease treatment, before discharge, and after Kawasaki treatment for at least three weeks. Comparison of moisture content.

[Fifth D] is the evaluation of the Kawasaki disease treatment effect in the general control group (health group), fever control group, Kawasaki disease treatment, Kawasaki disease treatment, before discharge, and Kawasaki disease treatment for at least three weeks. Comparison of blood oxygen concentration.

In view of the above technical features, the main effects of the Kawasaki disease optical detection method and apparatus of the present invention, and the method of optically evaluating the therapeutic effect of Kawasaki disease will be clearly shown in the following examples.

As shown in the first figure, the detecting device of the embodiment includes: a detecting light source (1), comprising a first light source (11), a second light source (12) and a third light source (13), The optical receiver (2) and a processor (3), in this embodiment, the detecting light source (1) and the optical receiver (2) are integrated in a control device (4). The detecting light source (1) and the light receiver (2) are connected to the processor (3), so that the processor (3) can operate the detecting light source (1) and the light receiver (2) to operate. Preferably, the detecting light source (1) and the light receiver (2) are wirelessly connected to the processor (3).

Referring to the second and third figures, the first light source (11) is used to emit a first light wave, the second light source (12) is used to emit a second light wave, and the third light source (13) is used for Send a third light wave. The wavelength of the first light wave is between 600 nm and 800 nm, the wavelength of the second light wave is between 800 nm and 920 nm, and the wavelength of the third light wave is between 920 nm and 1500. Between the rice. In this embodiment, the wavelength of the first light wave is 700 nm, the wavelength of the second light wave is 910 nm, and the wavelength of the third light wave is 950 nm. However, in actual use, light waves from the visible range to the near-infrared range can be used. The purpose of the above selection in this embodiment is that, for subsequent implementation, the degree of light attenuation is obvious after the light wave passes through the target.

Then, the Kawasaki disease optical detection method of the present embodiment is performed by referring to the following steps:

A. passing the first light wave, the second light wave, and the third light wave through a to-be-detected part of a healthy subject (generally the limbs of the healthy subject) and receiving the part to be detected The first light wave, the second light wave, and the third light wave that are absorbed by the tissue and whose intensity is attenuated. Referring to the fourth figure, the degree of light attenuation (transmittance, ΔOD) of the healthy subject to be tested is calculated: , wherein I _i (λ) and I _o (λ) represent the original incident light intensity of the wavelength λ and the light intensity absorbed by the human tissue, respectively, and the health is obtained according to the attenuation degree of the light wave and the absorption spectrum of the human tissue. The heme content, moisture content, and blood oxygen concentration of the test subject to be tested.

B. The first light wave, the second light wave, and the third light wave are further passed through a suspected portion of the suspected patient (also the limbs of the suspected patient), and the intensity attenuation is also obtained. a first light wave, the second light wave, and the third light wave. Similarly, as shown in the fourth figure, the degree of light attenuation of the suspected part to be detected is calculated to obtain the heme content, the moisture content, and the blood oxygen concentration of the suspected part to be detected.

C. The processor (3) receives the above data, and the hemoglobin content, the moisture content and the blood oxygen concentration of the suspected part to be detected, and the heme content and moisture of the healthy subject to be detected. The content and the blood oxygen concentration were compared and the results were compared.

It should be specially noted here that the processor (3) cannot directly determine whether the suspected person suffers from Kawasaki disease based on the comparison result of the above three values, and must still judge according to the clinical experience of the physician, for example, when hemoglobin If the content exceeds, the moisture content is at the standard value, and the blood oxygen concentration is at the standard value, or when the hemoglobin content is in the standard value, the moisture content is exceeded, and the blood oxygen concentration is exceeded, whether the suspected patient is ill or not, these conditions must be It is judged by the physician that the above values are clearer data provided by the physician for the doctor to make the most accurate diagnosis. Therefore, the case does not violate the second paragraph of the Patent Law, "Diagnosis, treatment or surgical methods of human or animal." It is a statutory non-patent issue.

Referring to Figures 5A through 5D, the present invention can further be used to evaluate the therapeutic effect of Kawasaki disease, such as the general control group (health group, HC) obtained in the figure, the fever control group (FC), and before Kawasaki disease treatment. (KD1), comparison of oxyhemoglobin, hemoglobin, water content and blood oxygen concentration after Kawasaki treatment to pre-discharge (KD2) and Kawasaki treatment for at least three weeks (KD3). It can be found that patients with Kawasaki disease have a significant decrease in oxygenated heme and hemoglobin relative to healthy people, but a significant increase in water content and blood oxygen concentration. Therefore, according to the above parameters to return to the normal speed, the therapeutic effect of Kawasaki disease can be evaluated.

Further, the hemoglobin content, the moisture content and the blood oxygen concentration of the healthy subject, and the hemoglobin content, the moisture content and the blood oxygen concentration of the plurality of Kawasaki patients can be input to a numerical analysis model for analysis ( For example, a neural network or fuzzy theory of a nonlinear model, and a linear judgment analysis of a linear model, to calculate an index of Kawasaki disease symptoms for each Kawasaki disease patient.

Therefore, the present invention provides a non-invasive optical detection method which can clinically help early diagnosis of Kawasaki disease. This method does not require collecting blood samples of sick children, and is completely non-invasive detection mode, creating a new auxiliary diagnosis Kawasaki. Disease tool. Assist the physician or parent to make a correct diagnosis within five to ten days of the child's fever, and successfully allow the child to receive high-dose immunoglobulin therapy, so as to significantly reduce the risk of Kawasaki's damage to the child's heart, as soon as possible and Immediate diagnosis is the most important key to the treatment of this disease, and the present invention can simultaneously evaluate the therapeutic effect of the patient.

In view of the foregoing description of the embodiments, the operation and the use of the present invention and the effects of the present invention are fully understood, but the above described embodiments are merely preferred embodiments of the present invention, and the invention may not be limited thereto. Included within the scope of the present invention are the scope of the present invention.

Claims (9)

An Kawasaki disease optical detection method includes the following steps: A. passing at least three light waves of different wavelengths through a to-be-detected portion of a healthy subject, and receiving the absorption by the tissue of the portion to be detected and attenuating the intensity More than three light waves, according to the attenuation state of the three or more light waves, the hemoglobin content and the moisture content of the part to be detected of the healthy subject are obtained according to the absorption spectrum of the human tissue; B. using the same method as the A step Measure a part of the suspected patient to be detected, and obtain three or more light waves of the intensity attenuation, and further obtain the hemoglobin content and the moisture content of the suspected part to be detected; C. A processor The hemoglobin content and the moisture content of the suspected part to be detected are compared with the hemoglobin content and the moisture content of the healthy subject to be detected, and the results of the comparison of the two values are output. According to the Kawasaki disease optical detection method described in the first aspect of the patent application, further, at least three or more light waves of different wavelengths are used to pass through the to-be-detected portion of the healthy subject and the suspected part to be detected. The blood oxygen concentration of the part to be detected of the healthy subject and the part to be detected of the suspected patient is further obtained, and the two are compared and the result of the comparison is output to obtain a comparison result of the third value. For example, the Kawasaki disease optical detection method described in the second application of the patent scope is further tested by using light waves of three different wavelengths, and the wavelength of the light wave is between 600 nm and 800 nm, respectively, between 800 From nanometer to 920 nm, and between 920 nm and 1500 nm. A method for optically evaluating the therapeutic effect of Kawasaki disease, comprising the steps of: A. passing at least three light waves of different wavelengths through a site to be detected of a healthy subject, and receiving absorption by the tissue of the site to be detected. And the three or more light waves whose intensity is attenuated are obtained according to the attenuation state of the three or more light waves and the absorption spectrum of the human tissue, and the blood of the healthy subject to be detected is obtained. Red pigment content and moisture content; B. Using a method similar to step A to detect a site to be detected in a Kawasaki disease patient, and obtaining three or more light waves of the intensity attenuation, and further obtaining the site to be detected of the Kawasaki disease patient The heme content and the moisture content; C. a processor compares the hemoglobin content and the moisture content of the Kawasaki disease patient to the hemoglobin content and the moisture content of the healthy subject to be tested, And outputting the comparison result, wherein the hemoglobin content and the moisture content of the healthy subject, and the hemoglobin content and the moisture content of the plurality of Kawasaki patients are input into a numerical analysis model for analysis, and each Kawasaki is calculated. Index of symptoms of Kawasaki disease in patients with symptoms. The method for optically evaluating the therapeutic effect of Kawasaki disease as described in claim 4, wherein the numerical analysis model is one of the following: a neural network or fuzzy theory of a nonlinear model, and a linear judgment analysis of a linear model. . The method for optically evaluating the therapeutic effect of Kawasaki disease as described in claim 4, and further, using at least three light waves of different wavelengths to pass through the to-be-detected portion of the healthy subject and the Kawasaki disease patient The part to be detected is further obtained by further obtaining the blood oxygen concentration of the part to be detected of the healthy subject and the part to be detected of the Kawasaki disease patient, and comparing the two to output a comparison result. A detecting device for performing the Kawasaki disease optical detecting method according to any one of claims 1 to 3, comprising: a detecting light source that emits at least three light waves of different wavelengths; and an optical receiver, The light wave for receiving the attenuation intensity; the processor signal is connected to the detection light source and the light receiver for operating the detection light source and the light receiver to receive the to-be-detected portion of the healthy subject And the hemoglobin content and the moisture content of the suspected part of the patient to be detected, and then obtain the hemoglobin content and the moisture content of the part to be detected of the healthy subject and the suspected part of the suspected patient. A comparison of the results. According to the Kawasaki disease optical detecting device described in claim 7, the detecting light source emits light waves of three or more different wavelengths, thereby further obtaining the to-be-detected portion of the healthy subject and the patient of the Kawasaki disease. The blood oxygen concentration of the test site is measured, and the results are compared after the two are compared. The Kawasaki disease optical detecting device according to claim 7, wherein the detecting light source and the light receiving device are connected to the processor in a wireless manner.