TWI589285B - Nerve sensing device with suppress interference - Google Patents
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Description
本發明涉及一種神經感測裝置,尤指一種具抑制交互干擾(interference)而可避免神經元受多個密集訊號彼此相互干擾的神經感測裝置。 The present invention relates to a neural sensing device, and more particularly to a neural sensing device having an interference to prevent interference of a plurality of dense signals with each other.
西元2002年,美國第二視力醫學產品公司(Second Sight Medical Products Inc.)將其所生產的實驗性電子眼Argus I為六位失明患者進行人體移植手術,Argus I為一仿生電子眼(bionic eye),其具有16個像素(pixels)的解析能力,讓失明患者可以藉由物體表面對光源反射之亮度差異辨識出物體的輪廓;到了2006年該公司更發表第二代的產品Argus II,其將影像解析能力提升到60個像素,可為使用者提供更佳的解析度及影像辨識的正確率。 In 2002, Second Sight Medical Products Inc. used its experimental electronic eye Argus I to perform human transplantation for six blind patients. Argus I is a bionic eye. It has a resolution of 16 pixels, which allows blind patients to recognize the contour of the object by the difference in brightness of the light reflected from the surface of the object. In 2006, the company released the second-generation Argus II, which will image The resolution is increased to 60 pixels, which provides users with better resolution and correct image recognition.
習知技術之實驗性電子眼Argus II的裝置包括置於使用者體外的一影像擷取裝置及置於使用者體內的一影像接收晶片,其中該影像擷取裝置包括一鏡架、一微型攝影機、一影像處理單元、一無線通訊模組,該鏡架係可移除地配置於使用者之臉上,且其上配置有該微型攝影機及該無線通訊模組,該微型攝影機係擷取使用者前方之影像,並產生一攝影資訊;該影像處理單元係配置於該鏡架之外,且連接至該微型攝影機,該影像處理單元接收該微型攝影機的攝影資訊,並產生一數位影像訊號;此時該無線通訊模組係接收該影像處理單元之該數位影像資訊,並將該數位影像資訊傳輸給該影像接收晶片,該影像接收晶片是配置於使用者之視網膜上,且連接於使用者之視網膜上的至少一視神經節,該影像接收晶片是將該數位影像資訊轉換成一神經脈波,並透過該至少一視神經節將該神經脈波傳輸於使用者的大腦,讓使用者感知到一影像。 The device of the experimental electronic eye Argus II of the prior art comprises an image capturing device disposed outside the user body and an image receiving wafer disposed in the user body, wherein the image capturing device comprises a frame, a miniature camera, An image processing unit, a wireless communication module, the frame is removably disposed on a face of the user, and the micro camera and the wireless communication module are disposed thereon, and the micro camera system captures the user An image of the front side, and generating a photographic information; the image processing unit is disposed outside the frame and connected to the micro camera, the image processing unit receives the photographic information of the micro camera, and generates a digital image signal; The wireless communication module receives the digital image information of the image processing unit, and transmits the digital image information to the image receiving chip. The image receiving chip is disposed on a retina of the user and is connected to the user. At least one optic ganglion on the retina, the image receiving chip converts the digital image information into a nerve pulse and transmits the A small section of the optic nerve pulse transmitted to the user's brain, so that the user perceives an image.
然而,習知技術之該影像接收晶片為提高使用者對影像的解析 度與辨識率,勢必於有限大小的晶片上增加更多的感光單元以提高像素數值,此時各感光單元間的間隙更近,將更容易使各感光單元於運作時產生的感測訊號彼此相互干擾,而削減了原始的有效像素數值;請參閱圖1,當兩相鄰感光單元10的感測訊號彼此干擾時,該兩相鄰感光單元10之間所疊加的訊號若高於使用者之至少一視神經節的一閥值,則使用者的至少一視神經節會把兩個感光單元10等辨識為一個大面積的感光單元11,並將所接收到的感測訊號傳輸於使用者的大腦,若所有感光單元10皆彼此干擾,則使用者將感知到一模糊的光影,而無法藉物體輪廓辨識影像,使具有高像素的影像接收晶片喪失提高使用者對影像之解析度與辨識率的功能。 However, the image receiving chip of the prior art is to improve the user's interpretation of the image. Degree and recognition rate, it is necessary to add more photosensitive cells on a limited size wafer to increase the pixel value. At this time, the gap between the photosensitive cells is closer, which makes it easier for the photosensitive cells to generate sensing signals when operating. Mutual interference, and the original effective pixel value is reduced; referring to FIG. 1, when the sensing signals of two adjacent photosensitive cells 10 interfere with each other, the signal superimposed between the two adjacent photosensitive cells 10 is higher than the user. At least one threshold of the optic ganglia, at least one optic ganglion of the user recognizes the two photosensitive units 10 and the like as a large-area photosensitive unit 11 and transmits the received sensing signal to the user. In the brain, if all the photosensitive cells 10 interfere with each other, the user will perceive a blurred light and shadow, and cannot recognize the image by the contour of the object, so that the image receiving wafer with high pixels is lost, and the resolution and recognition rate of the image are improved by the user. The function.
因此,本發明提出一種具抑制交互干擾(interference)且可避免神經元受多個密集訊號彼此干擾的神經感測裝置,兼具有體積小且高神經感測靈敏度與準確率的特性,實為目前各界亟欲解決之技術問題。 Therefore, the present invention provides a neural sensing device with interference suppression and avoiding interference of neurons with multiple dense signals, and has the characteristics of small volume and high sensitivity and accuracy of nerve sensing. At present, the technical problems that all walks of life want to solve.
鑒於前述之習知技術的缺點,本發明之主要目的係提供一種具抑制交互干擾的神經感測裝置,其可在不犧牲解析度的前提之下,避免視覺神經元受多個密集訊號彼此干擾,進而達到提高神經感測靈敏度與準確率的目的。 In view of the above-mentioned shortcomings of the prior art, the main object of the present invention is to provide a neural sensing device with suppressed interference, which can prevent visual neurons from being interfered with by multiple dense signals without sacrificing resolution. In order to improve the sensitivity and accuracy of nerve sensing.
為了達到前述目的及其他目的,本發明之具抑制交互干擾的神經感測裝置,包括:一感測單元陣列,係配置複數感測單元,各該複數感測單元產生一感測訊號;一控制訊號產生器,係連接至該感測單元陣列,且產生一控制訊號至各該複數感測單元之周圍,其中,該控制訊號的訊號強度低於該感測訊號的訊號強度,用以隔絕於各該複數感測單元之間的該感測訊號,以抑制交互干擾(interference);以及一訊號處理模組,係連接至該感測單元陣列及該控制訊號產生器,且產生及輸出一處理訊號至至少一視覺神經元;其中,該感測訊號高於該至少一視覺神經元的一閥值,以及該控制訊號低於該至少一視覺神經元的該閥值。 In order to achieve the foregoing and other objects, a neural sensing device for suppressing mutual interference includes: a sensing unit array configured with a plurality of sensing units, each of the plurality of sensing units generating a sensing signal; The signal generator is connected to the sensing unit array and generates a control signal to the periphery of each of the plurality of sensing units, wherein the signal strength of the control signal is lower than the signal strength of the sensing signal to isolate The sensing signal between the plurality of sensing units to suppress interference; and a signal processing module connected to the sensing unit array and the control signal generator, and generating and outputting a processing Signaling to at least one visual neuron; wherein the sensing signal is higher than a threshold of the at least one visual neuron, and the control signal is lower than the threshold of the at least one visual neuron.
較佳地,該感測單元陣列可為一電子視網膜晶片的一光電二極體陣列(photodiode array),各該複數感測單元為一光電二極體,以取代人類 視網膜上的感光細胞(photoreceptor cell)。 Preferably, the sensing unit array can be a photodiode array of an electronic retina wafer, and each of the plurality of sensing units is a photodiode to replace the human body. Photoreceptor cell on the retina.
較佳地,該控制訊號產生器可配置於一電子視網膜晶片之該感測單元陣列之一側上,且將該控制訊號傳輸至該訊號處理模組。 Preferably, the control signal generator is disposed on one side of the sensing unit array of an electronic retina chip, and transmits the control signal to the signal processing module.
較佳地,該神經感測裝置可直接連接至人類視網膜上的至少一神經節細胞(ganglion cell)。 Preferably, the neural sensing device is directly connectable to at least one ganglion cell on the human retina.
較佳地,該處理訊號可為至少一脈波(spike)。 Preferably, the processing signal can be at least one spike.
開始使用本發明之具抑制交互干擾的神經感測裝置時,該控制訊號產生器產生該控制訊號至各該複數感測單元之周圍,用以隔絕於各該複數感測單元之間的該感測訊號,以抑制交互干擾(interference),而避免該至少一視覺神經元發生誤動作;當該感測單元陣列感測到影像及/或光源時,該感測單元陣列上所配置的各該複數感測單元即依據該影像及/或該光源於空間中的光強弱分布產生該感測訊號,而由於前述各控制訊號隔離於各該感測訊號之間,故當該感測單元陣列感測到密集分布之光強弱變化的影像及/或光源時,可避免該至少一視覺神經元同時受到多個感測訊號彼此相互干擾,進而能夠達到達到提高神經感測靈敏度與準確率的目的。 When the neural sensing device of the present invention for suppressing mutual interference is started, the control signal generator generates the control signal to the periphery of each of the plurality of sensing units for isolating the sense between the plurality of sensing units. a signal signal to suppress interference (interference) to prevent the at least one visual neuron from malfunctioning; and when the sensing unit array senses an image and/or a light source, each of the plurality of configured on the sensing unit array The sensing unit generates the sensing signal according to the image and/or the light intensity distribution of the light source in the space, and the sensing unit array senses because the foregoing control signals are isolated between the sensing signals. When the image and/or the light source of the densely distributed light intensity changes, the at least one visual neuron can be prevented from being interfered with each other by the plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the neural sensing.
10‧‧‧感光單元 10‧‧‧Photosensitive unit
11‧‧‧感光單元 11‧‧‧Photosensitive unit
20‧‧‧感測單元陣列 20‧‧‧Sensor unit array
21‧‧‧感測單元 21‧‧‧Sensor unit
30‧‧‧控制訊號產生器 30‧‧‧Control signal generator
40‧‧‧訊號處理模組 40‧‧‧Signal Processing Module
50‧‧‧視覺神經元 50‧‧‧Visual neurons
60‧‧‧大腦 60‧‧‧ brain
圖1係顯示習知技術之實驗性電子眼的兩相鄰感光單元的感測訊號彼此干擾示意圖;圖2係根據本發明之具抑制交互干擾的神經感測裝置,顯示一第一實施例的一電路方塊示意圖;圖3係根據本發明之具抑制交互干擾的神經感測裝置,顯示該第一實施例的一感測單元陣列外觀示意圖;圖4係根據本發明之具抑制交互干擾的神經感測裝置,顯示該第一實施例的一感測訊號及一控制訊號耦合示意圖;以及圖5係根據本發明之具抑制交互干擾的神經感測裝置,顯示該第一實施例的。 1 is a schematic diagram showing the mutual interference of sensing signals of two adjacent photosensitive cells of an experimental electronic eye of the prior art; FIG. 2 is a neural sensing device for suppressing mutual interference according to the present invention, showing a first embodiment FIG. 3 is a schematic diagram showing the appearance of a sensing unit array according to the first embodiment; FIG. 4 is a schematic diagram showing the appearance of a sensing unit array according to the present invention; FIG. The measuring device displays a sensing signal and a control signal coupling diagram of the first embodiment; and FIG. 5 shows the nerve sensing device according to the present invention for suppressing mutual interference, which is shown in the first embodiment.
以下係藉由特定的具體實施例說明本發明之實施方式,熟悉此技藝之人士可由本說明書所揭示之內容輕易地瞭解本發明之其他優點及功效。本發明亦可藉由其他不同的具體實例加以施行或應用,本發明說明書中的各項細節亦可基於不同觀點與應用在不悖離本發明之精神下進行各種修飾與變更。 The embodiments of the present invention are described by way of specific examples, and those skilled in the art can readily appreciate the other advantages and advantages of the present invention. The invention may be embodied or applied in various other specific embodiments, and various modifications and changes may be made without departing from the spirit and scope of the invention.
須知,本說明書所附圖式繪示之結構、比例、大小等,均僅用以配合說明書所揭示之內容,以供熟悉此技藝之人士瞭解與閱讀,並非用以限定本發明可實施之限定條件,故不具技術上之實質意義,任何結構之修飾、比例關係之改變或大小之調整,在不影響本發明所能產生之功效及所能達成之目的下,均應落在本發明所揭示之技術內容得能涵蓋之範圍內。 It is to be understood that the structure, the proportions, the size and the like of the present invention are intended to be used in conjunction with the disclosure of the specification, and are not intended to limit the scope of the invention. The conditions are not technically meaningful, and any modification of the structure, change of the proportional relationship or adjustment of the size should be disclosed in the present invention without affecting the effects and achievable effects of the present invention. The technical content can be covered.
以下依據本發明之第一實施例,描述一具抑制交互干擾的神經感測裝置。 In the following, in accordance with a first embodiment of the present invention, a neural sensing device for suppressing crosstalk is described.
請參閱圖2及圖3所示,本發明之具抑制交互干擾的神經感測裝置包括:一感測單元陣列20、一控制訊號產生器30及一訊號處理模組40。其中,感測單元陣列20係配置有複數感測單元21,各複數感測單元21產生一感測訊號,其中,各感測訊號高於至少一視覺神經元50的一閥值,用以使至少一視覺神經元50感測到有效資訊,並將之傳輸給大腦60。依據本發明之第一實施例,感測單元陣列20為一電子視網膜晶片的一光電二極體陣列(photodiode array),各複數感測單元21為一光電二極體,以取代人類視網膜上的感光細胞(photoreceptor cell),即各複數感測單元21做為欲感測畫面的一個像素(pixel),其用以將自外界入射至各複數感測單元21之複數光子能量轉換為電子游離能並輸出電能,以產生相對應複數光子能量的感測訊號,並將感測訊號傳輸給訊號處理模組40。 As shown in FIG. 2 and FIG. 3 , the neural sensing device with the interference suppression device includes a sensing unit array 20 , a control signal generator 30 and a signal processing module 40 . The sensing unit array 20 is configured with a plurality of sensing units 21, and each of the plurality of sensing units 21 generates a sensing signal, wherein each sensing signal is higher than a threshold of the at least one visual neuron 50, so that At least one visual neuron 50 senses the effective information and transmits it to the brain 60. According to the first embodiment of the present invention, the sensing unit array 20 is a photodiode array of an electronic retina wafer, and each of the plurality of sensing units 21 is a photodiode to replace the human retina. A photoreceptor cell, that is, a plurality of sensing units 21 as a pixel of a picture to be sensed, for converting a plurality of photon energies incident from the outside to each of the plurality of sensing units 21 into electron free energy And outputting electrical energy to generate a sensing signal corresponding to the complex photon energy, and transmitting the sensing signal to the signal processing module 40.
請參閱圖2至圖4所示,控制訊號產生器30可連接感測單元陣列20,且可產生一控制訊號至各複數感測單元21之周圍,其中,控制訊號的訊號強度低於感測訊號的訊號強度,用以隔絕於各複數感測單元之間的感測訊號,以抑制交互干擾(interference);以及各控制訊號低於至少一視覺神經元50的閥值,用以避免使至少一視覺神經元50感測到有效資訊,且依據神經傳導理論指出,至少一視覺神經元50在經過一動作電位刺激之後由於鈉離子(Na+)通道的不活化而具有一段時間呈不反應期(refractory period),當至少一視覺神經元50處於不反應期的期間將無法對其他動作電位的刺激做出反應,本發明之第一實施例即藉此特性使各複數感測單元21之周圍的至少一視覺神經元50暫時處於不反應期,中止各至少一感測單元21產生的感測訊號於其周圍構成連鎖反應(chain reaction),而避免干擾至其他的感測單元,故不會有相鄰感測單元21之間所疊加之訊號強度高於至少一視覺神經元50之閥值的現象發生,且由於各控制訊號的訊號強度皆未達至少一視覺神經元50的閥值,故不會對至少一視覺神經元50構成有效資訊而影響大腦60對欲感測畫面的辨識。依據本發明之第一實施例,控制訊號產生器30可配置於一電子視網膜晶片之感測單元陣列20之一側上,且可將控制訊號傳輸至訊號處理模組40。 As shown in FIG. 2 to FIG. 4 , the control signal generator 30 can be connected to the sensing unit array 20 and can generate a control signal to the periphery of each of the plurality of sensing units 21 , wherein the signal strength of the control signal is lower than the sensing. The signal strength of the signal is used to isolate the sensing signal between the plurality of sensing units to suppress the interference; and the control signals are lower than the threshold of the at least one visual neuron 50 to avoid at least A visual neuron 50 senses effective information, and according to the theory of nerve conduction, at least one optic neuron 50 has a period of non-reactivity after a period of stimulation of an action potential due to inactivation of the sodium ion (Na + ) channel. (refractory period), when at least one of the visual neurons 50 is in a non-reactive period, it will not be able to respond to the stimulation of other action potentials, and the first embodiment of the present invention causes the periphery of each of the plurality of sensing units 21 At least one of the optic neurons 50 is temporarily in a non-reactive period, and the sensing signals generated by each of the at least one sensing unit 21 are suspended to form a chain reaction around them, thereby avoiding Disturbing to other sensing units, there is no phenomenon that the signal intensity superimposed between adjacent sensing units 21 is higher than the threshold of at least one visual neuron 50, and the signal strength of each control signal is not At least one threshold value of the visual neuron 50 does not constitute effective information for at least one of the visual neurons 50 and affects the recognition of the brain 60 for the image to be sensed. According to the first embodiment of the present invention, the control signal generator 30 can be disposed on one side of the sensing unit array 20 of an electronic retina chip, and the control signal can be transmitted to the signal processing module 40.
請參閱圖2及圖5所示,訊號處理模組40可連接至感測單元陣列20及控制訊號產生器30,且可產生及輸出一處理訊至至少一視覺神經元50。依據本發明之第一實施例,神經感測裝置可直接連接至人類視網膜上的至少一神經節細胞(ganglion cell),用以使訊號處理模組40取代人類視網膜上的雙極細胞(bipolar cell)及/或水平細胞(horizontal cell),其中,各至少一神經節細胞是由功能相同之至少一視覺神經元50所集合而成的結節狀構造體。雙極細胞用於增強訊號邊緣差異,提高大腦60所感知之影像的銳利度,即銳利化(sharpen),而水平細胞用於減弱影像邊緣差異,降低大腦60所感知之影像的銳利度,即模糊化(blur)。 Referring to FIG. 2 and FIG. 5, the signal processing module 40 can be connected to the sensing unit array 20 and the control signal generator 30, and can generate and output a processing signal to at least one visual neuron 50. According to a first embodiment of the present invention, the neural sensing device can be directly connected to at least one ganglion cell on the human retina for enabling the signal processing module 40 to replace the bipolar cell on the human retina. And/or horizontal cells, wherein each at least one ganglion cell is a nodular construct composed of at least one visual neuron 50 having the same function. Bipolar cells are used to enhance signal edge differences and improve the sharpness of the images perceived by the brain 60, ie, sharpens, while horizontal cells are used to attenuate image edge differences and reduce the sharpness of the image perceived by the brain 60. Blurring.
在本發明之第一實施例中,處理訊號可為至少一脈波(spike),訊號處理模組40將各複數感測單元21的感測訊號與控制訊號進行耦合之後,產生並輸出至少一脈波給至少一視覺神經元50。 In the first embodiment of the present invention, the processing signal may be at least one spike, and the signal processing module 40 couples the sensing signals of the complex sensing units 21 with the control signals to generate and output at least one. The pulse wave gives at least one visual neuron 50.
於開始使用本發明時,先將感測單元陣列20配置於一使用者的視網膜上,且使感測單元陣列20上的至少一感測單元21朝向使用者外側,以感測使用者視網膜之外的影像,將訊號處理模組40連接至人類視網膜上的至少一神經節細胞,以傳輸處理訊號給至少一視覺神經元50,接著,控制訊號產生器30產生控制訊號至各複數感測單元21之周圍,用以隔絕於各複數感測單元之間的感測訊號,以抑制複數個感測訊號互相干擾,而避免使至少一視覺神經元50發生誤動作。當感測單元陣列20感測到影像及/或光源時,感測單元陣列20上所配置的各複數感測單元21即依據影像及/ 或光源於空間中的光強弱分布產生感測訊號,而由於前述各控制訊號隔離於各感測訊號之間,故當感測單元陣列20感測到密集分布之光強弱變化的影像及/或光源時,可避免至少一視覺神經元50同時受到多個感測訊號彼此相互干擾,進而能夠達到達到提高神經感測靈敏度與準確率的目的。 When the present invention is used, the sensing unit array 20 is first disposed on a user's retina, and at least one sensing unit 21 on the sensing unit array 20 is oriented toward the outside of the user to sense the user's retina. The external image connects the signal processing module 40 to at least one ganglion cell on the human retina to transmit a processing signal to at least one visual neuron 50. Then, the control signal generator 30 generates a control signal to each of the complex sensing units. A sensing signal is interposed between the plurality of sensing units to prevent the plurality of sensing signals from interfering with each other to prevent the at least one visual neuron 50 from malfunctioning. When the sensing unit array 20 senses an image and/or a light source, each of the plurality of sensing units 21 disposed on the sensing unit array 20 is based on the image and/or Or the light intensity distribution of the light source in the space generates a sensing signal, and since the foregoing control signals are isolated between the sensing signals, when the sensing unit array 20 senses a densely distributed image of light intensity changes and/or When the light source is used, at least one of the visual neurons 50 can be prevented from being interfered with each other by the plurality of sensing signals at the same time, thereby achieving the purpose of improving the sensitivity and accuracy of the neural sensing.
儘管已參考本申請的許多說明性實施例描述了實施方式,但應瞭解的是,本領域技術人員能夠想到多種其他改變及實施例,這些改變及實施例將落入本公開原理的精神與範圍內。尤其是,在本公開、圖式以及所附申請專利範圍的範圍內,對主題結合配置的組成部分及/或配置可作出各種變化與修飾。除對組成部分及/或配置做出的變化與修飾之外,可替代的用途對本領域技術人員而言將是顯而易見的。 Although the embodiments have been described with reference to the embodiments of the present invention, it will be understood that Inside. In particular, various changes and modifications can be made in the components and/or arrangements of the subject combination arrangements in the scope of the disclosure and the scope of the appended claims. Alternative uses will be apparent to those skilled in the art, in addition to variations and modifications in the component parts and/or configuration.
20‧‧‧感測單元陣列 20‧‧‧Sensor unit array
21‧‧‧感測單元 21‧‧‧Sensor unit
30‧‧‧控制訊號產生器 30‧‧‧Control signal generator
40‧‧‧訊號處理模組 40‧‧‧Signal Processing Module
50‧‧‧神經元 50‧‧‧ neurons
60‧‧‧大腦 60‧‧‧ brain
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