TWI562985B - Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates - Google Patents
Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyratesInfo
- Publication number
- TWI562985B TWI562985B TW100124167A TW100124167A TWI562985B TW I562985 B TWI562985 B TW I562985B TW 100124167 A TW100124167 A TW 100124167A TW 100124167 A TW100124167 A TW 100124167A TW I562985 B TWI562985 B TW I562985B
- Authority
- TW
- Taiwan
- Prior art keywords
- oxobutyrates
- hydroxymethylene
- fluoro
- preparation
- enolate salts
- Prior art date
Links
- MSSZJLSQYWUPOA-UHFFFAOYSA-N 4-fluoro-2-(hydroxymethylidene)-3-oxobutanoic acid Chemical class C(C(=O)C(=CO)C(=O)O)F MSSZJLSQYWUPOA-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/62—Preparation of carboxylic acid halides by reactions not involving the carboxylic acid halide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10007208 | 2010-07-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201206879A TW201206879A (en) | 2012-02-16 |
| TWI562985B true TWI562985B (en) | 2016-12-21 |
Family
ID=43086152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100124167A TWI562985B (en) | 2010-07-13 | 2011-07-08 | Process for the preparation of enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9156771B2 (zh) |
| EP (1) | EP2593420B1 (zh) |
| JP (1) | JP5911859B2 (zh) |
| KR (1) | KR101870462B1 (zh) |
| CN (1) | CN103153939B (zh) |
| AR (1) | AR082159A1 (zh) |
| AU (1) | AU2011278705A1 (zh) |
| BR (1) | BR112013000763A2 (zh) |
| CA (1) | CA2806717A1 (zh) |
| ES (1) | ES2610147T3 (zh) |
| HU (1) | HUE033005T2 (zh) |
| TW (1) | TWI562985B (zh) |
| UY (1) | UY33507A (zh) |
| WO (1) | WO2012007142A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114105792B (zh) * | 2022-01-14 | 2023-03-31 | 山东国邦药业有限公司 | 一种环丙沙星关键中间体的制备方法 |
| CN114933543B (zh) * | 2022-07-21 | 2022-10-28 | 山东国邦药业有限公司 | 一种3-环丙胺基-2-(2,4-二氯-5-氟苯甲酰基)丙烯酸甲酯的合成方法 |
| CN115010753A (zh) * | 2022-07-27 | 2022-09-06 | 南京工业大学 | 一种水相中制备磷酸化偕二氟二烯烃化合物的方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434267A (en) * | 1991-12-20 | 1995-07-18 | Bayer Aktiengesellschaft | Process for the preparation of substituted 3-alkoxyacrylates |
| JP2007326784A (ja) * | 2006-06-06 | 2007-12-20 | Sagami Chem Res Center | １−置換−５−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法 |
| WO2009106619A1 (en) * | 2008-02-29 | 2009-09-03 | Basf Se | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2394255A (en) * | 1942-04-07 | 1946-02-05 | American Cyanamid Co | Formylacetic ester |
| US3637812A (en) * | 1967-10-02 | 1972-01-25 | Merck & Co Inc | Acylation of reactive organic acid esters |
| DE2952070C2 (de) * | 1979-12-22 | 1983-09-08 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von Alkaliformylessigsäurealkylester |
| JPS61152640A (ja) * | 1984-12-26 | 1986-07-11 | Daicel Chem Ind Ltd | アルカリホルミルカルボン酸エステルの製法 |
| JPH0822853B2 (ja) | 1987-10-23 | 1996-03-06 | 三井東圧化学株式会社 | ピラゾール−４−カルボン酸類およびその製造方法 |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| US5616713A (en) * | 1996-07-22 | 1997-04-01 | Development Center For Biotechnology | Process of preparing 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine |
| JP2004325727A (ja) * | 2003-04-24 | 2004-11-18 | Konica Minolta Medical & Graphic Inc | 熱現像装置 |
| US20080108686A1 (en) | 2004-06-18 | 2008-05-08 | Basf Aktiengesellschaft | N-(Ortho-Phenyl)-1-Methyl-3-Difluoromethylpyrazole-4-Carboxanilides And Their Use As Fungicides |
| JP4114754B2 (ja) | 2005-02-25 | 2008-07-09 | 財団法人相模中央化学研究所 | １−置換−３−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法 |
| JP5340287B2 (ja) * | 2007-08-16 | 2013-11-13 | ソルヴェイ（ソシエテ アノニム） | ４−フルオロ置換３−オキソ−アルカン酸のエステル類の調製方法 |
-
2011
- 2011-07-08 TW TW100124167A patent/TWI562985B/zh not_active IP Right Cessation
- 2011-07-11 ES ES11731280.1T patent/ES2610147T3/es active Active
- 2011-07-11 KR KR1020137000594A patent/KR101870462B1/ko not_active Expired - Fee Related
- 2011-07-11 AU AU2011278705A patent/AU2011278705A1/en not_active Abandoned
- 2011-07-11 BR BR112013000763A patent/BR112013000763A2/pt not_active Application Discontinuation
- 2011-07-11 US US13/809,739 patent/US9156771B2/en not_active Expired - Fee Related
- 2011-07-11 WO PCT/EP2011/003445 patent/WO2012007142A1/en not_active Ceased
- 2011-07-11 JP JP2013518985A patent/JP5911859B2/ja active Active
- 2011-07-11 CN CN201180032843.4A patent/CN103153939B/zh not_active Expired - Fee Related
- 2011-07-11 EP EP11731280.1A patent/EP2593420B1/en not_active Not-in-force
- 2011-07-11 CA CA2806717A patent/CA2806717A1/en not_active Abandoned
- 2011-07-11 HU HUE11731280A patent/HUE033005T2/hu unknown
- 2011-07-12 UY UY0001033507A patent/UY33507A/es not_active Application Discontinuation
- 2011-07-12 AR ARP110102507A patent/AR082159A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5434267A (en) * | 1991-12-20 | 1995-07-18 | Bayer Aktiengesellschaft | Process for the preparation of substituted 3-alkoxyacrylates |
| JP2007326784A (ja) * | 2006-06-06 | 2007-12-20 | Sagami Chem Res Center | １−置換−５−フルオロアルキルピラゾール−４−カルボン酸エステルの製造方法 |
| WO2009106619A1 (en) * | 2008-02-29 | 2009-09-03 | Basf Se | Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5911859B2 (ja) | 2016-04-27 |
| EP2593420B1 (en) | 2016-10-19 |
| ES2610147T3 (es) | 2017-04-26 |
| UY33507A (es) | 2012-01-31 |
| JP2013535430A (ja) | 2013-09-12 |
| HK1186172A1 (zh) | 2014-03-07 |
| KR101870462B1 (ko) | 2018-06-22 |
| TW201206879A (en) | 2012-02-16 |
| KR20130140603A (ko) | 2013-12-24 |
| US20130338394A1 (en) | 2013-12-19 |
| HUE033005T2 (hu) | 2017-11-28 |
| CA2806717A1 (en) | 2012-01-19 |
| AR082159A1 (es) | 2012-11-14 |
| EP2593420A1 (en) | 2013-05-22 |
| US9156771B2 (en) | 2015-10-13 |
| CN103153939A (zh) | 2013-06-12 |
| AU2011278705A1 (en) | 2013-02-28 |
| BR112013000763A2 (pt) | 2016-05-24 |
| CN103153939B (zh) | 2016-01-20 |
| WO2012007142A1 (en) | 2012-01-19 |
| WO2012007142A8 (en) | 2013-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |