TWI560181B - Process for the preparation of 5-fluoro-1-alkyl-3-fluoroalkyl-1h-pyrazole-4-carbonyl chlorides and fluorides - Google Patents
Process for the preparation of 5-fluoro-1-alkyl-3-fluoroalkyl-1h-pyrazole-4-carbonyl chlorides and fluoridesInfo
- Publication number
- TWI560181B TWI560181B TW100113969A TW100113969A TWI560181B TW I560181 B TWI560181 B TW I560181B TW 100113969 A TW100113969 A TW 100113969A TW 100113969 A TW100113969 A TW 100113969A TW I560181 B TWI560181 B TW I560181B
- Authority
- TW
- Taiwan
- Prior art keywords
- fluorides
- fluoroalkyl
- pyrazole
- fluoro
- alkyl
- Prior art date
Links
- 150000002222 fluorine compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32726910P | 2010-04-23 | 2010-04-23 | |
| EP10160885 | 2010-04-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201206890A TW201206890A (en) | 2012-02-16 |
| TWI560181B true TWI560181B (en) | 2016-12-01 |
Family
ID=42836944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW100113969A TWI560181B (en) | 2010-04-23 | 2011-04-22 | Process for the preparation of 5-fluoro-1-alkyl-3-fluoroalkyl-1h-pyrazole-4-carbonyl chlorides and fluorides |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8431718B2 (zh) |
| EP (1) | EP2560961B1 (zh) |
| JP (1) | JP5819938B2 (zh) |
| KR (1) | KR101774966B1 (zh) |
| CN (1) | CN103140477B (zh) |
| BR (1) | BR112012027170B1 (zh) |
| DK (1) | DK2560961T3 (zh) |
| ES (1) | ES2616005T3 (zh) |
| IL (1) | IL222627A (zh) |
| MX (1) | MX2012012085A (zh) |
| TW (1) | TWI560181B (zh) |
| WO (1) | WO2011131615A1 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR076839A1 (es) * | 2009-05-15 | 2011-07-13 | Bayer Cropscience Ag | Derivados fungicidas de pirazol carboxamidas |
| WO2014023667A1 (en) * | 2012-08-07 | 2014-02-13 | Bayer Cropscience Ag | Method for the preparation of perfluoroalkyl containing pyrazoles carboxylates |
| BR112015015833B1 (pt) * | 2013-01-17 | 2020-05-19 | Bayer Cropscience Ag | processo de preparação de 5-fluoro-1 -metil-3-difluorometil-1 h-pirazol-4-carbaldeído |
| WO2014122083A1 (de) | 2013-02-06 | 2014-08-14 | Bayer Cropscience Ag | Halogensubstituierte pyrazolderivate als schädlingsbekämpfungsmittel |
| ES2641217T3 (es) * | 2013-09-20 | 2017-11-08 | Bayer Cropscience Aktiengesellschaft | Procedimiento de preparación de 5-fluoro-1-alquil-3-fluoroalquil-1H-pirazol-4-carbaldehído |
| KR20160104065A (ko) | 2014-01-03 | 2016-09-02 | 바이엘 애니멀 헬스 게엠베하 | 농약으로서의 신규 피라졸릴헤테로아릴아미드 |
| ES2657424T3 (es) * | 2014-01-24 | 2018-03-05 | Bayer Cropscience Aktiengesellschaft | Procedimiento de preparación de 1-alquil-3-difluorometil-5-fluor-1H-pirazol-4-carbaldehídos y 1-alquil-3-difluorometil-5-fluor-1H-pirazol-4-carboxilatos |
| TWI705055B (zh) * | 2015-04-29 | 2020-09-21 | 德商拜耳作物科學公司 | 製備5-氟-1h-吡唑-4-羰基氟化物之方法 |
| CN106380447B (zh) * | 2016-08-29 | 2019-09-13 | 联化科技（台州）有限公司 | 3-二氟甲基-1-甲基-1h-吡唑-4-甲酸及其中间体的制备方法及中间体 |
| WO2021063880A1 (en) * | 2019-10-04 | 2021-04-08 | Basf Se | Preparation of 2-chloro-1-(2-chlorothiazol-5-yl)ethanone |
| CN112174891B (zh) * | 2020-11-02 | 2022-02-01 | 浙江省农业科学院 | 一种氟唑菌苯胺代谢物的制备方法 |
| WO2022233129A1 (en) | 2021-05-05 | 2022-11-10 | Fujian Yongjing Technology Co., Ltd | New process for the synthesis of 5-fluoro-3- (difuoromethyl) -5-fluoro-1-methyl-1h-pyrazole-4-carboxylic acid derivatives and the free acid thereof |
| EP4103553A4 (en) * | 2021-05-05 | 2023-01-18 | Fujian Yongjing Technology Co., Ltd | NEW PROCESS FOR THE SYNTHESIS OF 5-FLUORO-3-(DIFLUOROMETHYL)-5-FLUORO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND ASSOCIATED FREE ACID |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223526A (en) * | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
| JPH0710845A (ja) * | 1993-06-24 | 1995-01-13 | Sumitomo Chem Co Ltd | ５−クロロピラゾール−４−カルボニルクロリド類の製造方法 |
| CN101268055A (zh) * | 2005-09-17 | 2008-09-17 | 拜尔农作物科学股份公司 | 制备5-氟-1,3-二烷基-1h-吡唑-4-羰基氟化物的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4698093A (en) * | 1984-11-06 | 1987-10-06 | Monsanto Company | Herbicidal (2 or 6)-fluoroalkyl-4-amino pyridine derivatives |
| JPH0285257A (ja) * | 1988-09-21 | 1990-03-26 | Sumitomo Chem Co Ltd | 置換ピラゾール−４−カルボン酸クロリドの製造法 |
| US5093347A (en) | 1991-01-28 | 1992-03-03 | Monsanto Company | 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use |
| JPH0543553A (ja) * | 1991-08-14 | 1993-02-23 | Nissan Chem Ind Ltd | ３，５−ジクロロピラゾール−４−カルボン酸エステル類の製造方法 |
| IL105939A0 (en) * | 1992-06-11 | 1993-10-20 | Rhone Poulenc Agriculture | Herbicidal compounds and compositions |
| GB9219779D0 (en) * | 1992-09-18 | 1992-10-28 | Rhone Poulenc Agriculture | Compositions of new matter |
| CA2203628A1 (en) * | 1995-08-31 | 1997-03-06 | Dow Agrosciences Llc | N-(1-ethyl-4-pyrazolyl)triazoloazinesulfonamide herbicides |
| DE19544800A1 (de) | 1995-12-01 | 1997-06-05 | Bayer Ag | Verfahren zur Herstellung von 1,3-Dimethyl-5-fluor-pyrazol-4-carboxaniliden |
| JP4465133B2 (ja) | 2001-02-08 | 2010-05-19 | クミアイ化学工業株式会社 | イソオキサゾリン誘導体及びこれを有効成分とする除草剤 |
| DE10303589A1 (de) * | 2003-01-29 | 2004-08-12 | Bayer Cropscience Ag | Pyrazolylcarboxanilide |
| US7071333B2 (en) * | 2003-07-30 | 2006-07-04 | Bristol-Myers Squibb Company | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
| DE10340569A1 (de) | 2003-09-01 | 2005-04-07 | Koenig & Bauer Ag | Verfahren zur Reduktion von Passerfehlern auf einer in einer bahnverarbeitenden Vorrichtung und ein Druckwerk |
| WO2005070889A1 (en) * | 2004-01-23 | 2005-08-04 | E.I. Dupont De Nemours And Company | Herbicidal amides |
| EP1761498A1 (de) | 2004-06-18 | 2007-03-14 | Basf Aktiengesellschaft | 1-methyl-3-difluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid |
| DE102005057180A1 (de) | 2005-12-01 | 2007-06-06 | Bayer Cropscience Ag | Verfahren zum Herstellen von 5-fluor-1,3-dialkyl-1H-pyrazol-4-carbonsäurefluoriden |
| AR056882A1 (es) | 2006-02-01 | 2007-10-31 | Bayer Cropscience Sa | Derivados del fungicida n- cicloalquil- bencil- amida |
| DE102006039909A1 (de) | 2006-08-25 | 2008-03-13 | Bayer Cropscience Ag | Verfahren zum Herstellen von 3-Dihalomethyl-pyrazol-4-carbonsäurederivaten |
| EP2113500A1 (en) * | 2006-10-31 | 2009-11-04 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
| AR076839A1 (es) * | 2009-05-15 | 2011-07-13 | Bayer Cropscience Ag | Derivados fungicidas de pirazol carboxamidas |
| EP2251331A1 (en) | 2009-05-15 | 2010-11-17 | Bayer CropScience AG | Fungicide pyrazole carboxamides derivatives |
| EP2325173A1 (de) | 2009-11-19 | 2011-05-25 | Bayer CropScience AG | Verfahren zum Herstellen von 5-Fluor-1-alkyl-3-fluoralkyl-1H-pyrazol-4-carbonsäurechloriden |
-
2011
- 2011-04-18 CN CN201180020594.7A patent/CN103140477B/zh active Active
- 2011-04-18 ES ES11714986.4T patent/ES2616005T3/es active Active
- 2011-04-18 MX MX2012012085A patent/MX2012012085A/es active IP Right Grant
- 2011-04-18 JP JP2013505432A patent/JP5819938B2/ja active Active
- 2011-04-18 WO PCT/EP2011/056119 patent/WO2011131615A1/de not_active Ceased
- 2011-04-18 DK DK11714986.4T patent/DK2560961T3/en active
- 2011-04-18 KR KR1020127030136A patent/KR101774966B1/ko active Active
- 2011-04-18 BR BR112012027170-9A patent/BR112012027170B1/pt active IP Right Grant
- 2011-04-18 EP EP11714986.4A patent/EP2560961B1/de active Active
- 2011-04-22 US US13/092,429 patent/US8431718B2/en active Active
- 2011-04-22 TW TW100113969A patent/TWI560181B/zh active
-
2012
- 2012-10-23 IL IL222627A patent/IL222627A/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223526A (en) * | 1991-12-06 | 1993-06-29 | Monsanto Company | Pyrazole carboxanilide fungicides and use |
| JPH0710845A (ja) * | 1993-06-24 | 1995-01-13 | Sumitomo Chem Co Ltd | ５−クロロピラゾール−４−カルボニルクロリド類の製造方法 |
| CN101268055A (zh) * | 2005-09-17 | 2008-09-17 | 拜尔农作物科学股份公司 | 制备5-氟-1,3-二烷基-1h-吡唑-4-羰基氟化物的方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103140477B (zh) | 2015-07-15 |
| BR112012027170B1 (pt) | 2018-02-14 |
| ES2616005T3 (es) | 2017-06-09 |
| CN103140477A (zh) | 2013-06-05 |
| EP2560961B1 (de) | 2016-11-16 |
| IL222627A (en) | 2014-09-30 |
| BR112012027170A2 (pt) | 2015-09-15 |
| WO2011131615A1 (de) | 2011-10-27 |
| US8431718B2 (en) | 2013-04-30 |
| KR20130052570A (ko) | 2013-05-22 |
| MX2012012085A (es) | 2012-11-29 |
| JP2013525324A (ja) | 2013-06-20 |
| TW201206890A (en) | 2012-02-16 |
| KR101774966B1 (ko) | 2017-09-05 |
| EP2560961A1 (de) | 2013-02-27 |
| JP5819938B2 (ja) | 2015-11-24 |
| DK2560961T3 (en) | 2017-02-20 |
| US20110288305A1 (en) | 2011-11-24 |
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