TWI411445B - 可起泡沫的氟化物口腔照護組成物 - Google Patents
可起泡沫的氟化物口腔照護組成物 Download PDFInfo
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- TWI411445B TWI411445B TW097137437A TW97137437A TWI411445B TW I411445 B TWI411445 B TW I411445B TW 097137437 A TW097137437 A TW 097137437A TW 97137437 A TW97137437 A TW 97137437A TW I411445 B TWI411445 B TW I411445B
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- composition
- foam
- container
- fluoride
- surfactant
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- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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Description
齲齒之有效的醫藥管理係具有齲齒增加風險因子之患者族群所需要的。已知於所見之人口中，特定患者次族群出現齲齒者佔實際比例齲齒中之大多數。報導中指出在美國，25%兒童為具齲齒者之75%。
一種目前用來降低兒童齲齒之作法係周期性地，例如每年1至2次，施用可釋放具有相當高濃度氟化物之鹽，例如1-3重量%氟化鈉之可起泡沫的氟化物組成物，其係與氣溶膠推進劑組合包裝於氣溶膠容器中。該組成物係由容器中分送至牙科器皿之溝槽，以呈稠密、穩定、非-流動性的泡沫，將其疊置於所要治療之牙齒周圍且鑲合於其內，使得氟化物可被牙齒琺瑯質所提取。
雖然習用牙用泡沫具效益且為目前商業上所使用，但實際上，其所產生之濃厚，稠密的泡沫於處理時會使患者感覺不舒服。此外，處理完畢時，所殘留之稠密泡沫不易自患者之口腔中移除及/或耗時。至少鑑於此等理由，習用泡沫在專業用途上及使用氟化物處理之患者配合度上不受歡迎。
因此，於此方面技藝中所需要的是可促進專業使用且迎合患者需要之用於處理牙齒表面的改良性牙用氟化物泡沫組成物，以便可以在一段時間內重複進行處理而提供對於齲齒有效的氟化物處理。
本發明係包含低密度可起泡沫的口腔照護組成物，其包括含有下列之水溶液：可釋放氟離子之鹽；選自包括下列群組之表面活性劑：非離子性表面活性劑、兩性離子表面活性劑、甜菜鹼表面活性劑，及其混合物；及數量足以調整組成物之pH至約3至約5之酸化劑，其中，當保存於4.4℃(40℉)之溫度達12小時，組成物實質上不含沉澱物。
亦包含於本發明中者為相關的方法。
本發明係提供可起泡沫的口腔照護組成物及給予或施用至人類或其他動物個體，或與其等一起使用的方法。本文中所指之「口腔照護組成物」為適合給予或施用至人類或動物個體之口腔，以增進個體之健康，衛生或外觀，較佳係提供此等利益如預防或治療生理症狀或疾病，提供感覺、裝飾或化妝效益之任何組成物及其組合。於各種具體例中，口腔照護組成物並非用於吞嚥，而是於口腔中停留一段足以影響所意欲效用的時間。因此使用於本發明中之特定物質及組成物宜為製藥上-或化妝品上-可接受者。本文中所用之例如，「製藥上可接受的」或「化妝品上可接受的」組份，或於「安全及有效量」所使用之組份為適用於人類及/或動物上，以提供所想要之治療、預防、感覺、裝飾，或化妝利益，無不當有害效應(例如，毒性、刺激性，及過敏反應)而具同等合理利益/風險比例者。
於各種具體例中，本發明係提供低密度，可起泡沫的牙用氟化物泡沫。於特定具體例中，該組成物係包裝於形成泡沫之容器中。該組成物包括含有下列之水溶液：水溶性可釋放氟離子之鹽；選自包括下列群組之表面活性劑：非離子性表面活性劑、兩性離子表面活性劑、甜菜鹼表面活性劑，及其混合物；及數量足以調整組成物之pH至約3至約5之口相容性酸化劑。於一個具體例中，當保存於4.4℃(40℉)之溫度達12小時，組成物實質上為不含沉澱物之澄清溶液。本文中所用之「實質上不含沉澱物」一詞係指組成物不含人類肉眼可看到之任何沉澱物，亦即，無需藉助人工裝置。
於各種具體例中，該組成物具有大於約29.4℃(85℉)，宜大於約37.7℃(100℉)之上溶解溫度，及低於約4.4℃(40℉)之低溶解溫度，因而提供穩定且實質上澄清之溶液。當由容器中分送至牙科器皿之溝槽時，組成物形成低密度，快速崩塌的泡沫，其實質上於形成泡沫之容器中分送出來且與患者之牙齒接觸後約1分鐘或更短時間內液化，之後其可容易地沖洗且從患者之口腔中移除。
本說明書中所用之「崩塌的泡沫」一詞係指泡沫其為可崩塌的泡沫；亦即，於牙科器皿之溝槽中形成泡沫且於放置在患者之牙齒後不超過約2分鐘期間變成實際的液體。於該短期間後，氣溶膠泡沫實質上崩塌成液體且患者之牙齒可經簡單沖洗而清除殘留泡沫。
於各種具體例中，用於製備可起泡沫之口腔組成物之口腔中可接受的牙膏載體包括水-相。製備商業上適當之牙用泡沫、牙膏、凝膠，及漱口水時所使用的水宜為去離子且不含有機雜質。本文中，可起泡沫之牙用氟化物組成物一般包含約85%至98%，宜為約90%至95%的水。於一個具體例中，去離子水係以約91%之含量提供。所加入的水為游離水，其係與所引進之其他物質及組成份一起加入。
本發明之水溶性可釋放氟離子之鹽為可用作為例如，抗齲齒劑之氟離子來源。氟離子，或氟化物-提供劑之來源為可微溶於水或可完全溶於水者。其等之特徵在於其等可於水中釋放氟離子之能力，其等不與口腔製劑之其他化合物進行不想要的反應，及其等之抗齲齒活性。任何口腔中可接受之氟離子來源皆可使用。非-限制性之實例包括可溶性鹼金屬或鹼土金屬鹽類例如氟化鈉，氟化鉀，及氟化鈣；氟化銨；氟化銅例如氟化亞銅；氟化鋅；氟化鋇；氟矽酸鈉；氟矽酸銨；氟鋯酸鈉；單氟磷酸鈉；單氟-及二氟磷酸鋁；及經氟化之焦磷酸鈉鈣。較佳者為鹼金屬及錫氟化物，例如鈉及亞錫氟化物、氟化銦、單氟磷酸鈉(MFP)，及其混合物。於特定之具體例中，所使用之氟化胺包括歐拉氟(olaflur)(N'-十八基三亞甲基二胺-N,N,N'-三(2-乙醇)-氟化二氫)。
氟化物-提供劑之量係依化合物之種類，其之溶解度，及口服製劑之種類而達特定含量，但其必須為非-毒性量。於各種具體例中，係使用且提供安全及有效量之水溶性可釋放氟離子之鹽。一種或多種氟離子來源係典型地以提供氟化物離子約5,000p.p.m.至約50,000p.p.m.，或者約10,000p.p.m.至約30,000p.p.m.，或約11,000p.p.m.、約12,000p.p.m.、約13,000p.p.m.、約14,000p.p.m.或約17,000p.p.m.之量存在。
表面活性劑包括作用為表面活性劑、乳化劑、及/或泡沫調節劑之組份。表面活性劑一般係藉著將氟化物離子徹底分散於整個口腔中而增加預防作用。適當的乳化劑包括那些合理的穩定且於大範圍pH內起泡者。此外，較佳的表面活性劑於低溫下例如4.4℃(40℉)時形成穩定的組成物。此使得本發明組成物更成為化妝品上可接受者且提高保留於溶液中之活性的可利用性。
有機表面活性物質宜選自非離子性及兩性離子表面活性劑。亦可使用表面活性劑之混合物。於特定具體例中，口腔組成物中含有一種或多種表面活性劑於約0.1%至約3%，且較佳為約0.6%至約1.5%之範圍，其中，所有的百分比係以口腔組成物總重量計之重量計。
適當的非離子性表面活性劑包括氧化乙烯/氧化丙烯阻斷共聚物(例如，聚羥亞烴或普朗尼(Pluronic)表面活性劑)；烷基苯酚之聚氧化乙烯縮合物；由氧化乙烯與氧化丙烯及乙二胺之反應產物進行縮合作用所衍生之產物；脂族醇之氧化乙烯縮合物；長鏈第三胺氧化物；長鏈第三膦氧化物；長鏈二烷基亞碸；及脂肪酸之山梨糖醇酐酯與氧化乙烯之縮合物(聚山梨糖醇酯)。
山梨糖醇酐酯乙氧酸酯之非-限制性實例包括具有約20至約60莫耳氧化乙烯之山梨糖醇酐脂肪酸酯(例如，美國德拉威州威明頓市ICI美國公司之商標Tween表面活性劑)。特別佳之聚山梨酸酯為聚山梨酸酯20(聚氧化乙烯20山梨糖醇酐單月桂酸酯，Tween20)及聚山梨酸酯80(聚氧化乙烯20山梨糖醇酐單-油酸酯，Tweens80)。
適當的聚羥亞烴表面活性劑包括具有平均分子量為約3,000至約15,000之聚(氧基伸乙基)-聚(氧基伸丙基)阻斷共聚物。中間體平均分子量可為約6,000至約15,000，以約10,000至約15,000之平均分子量較佳。此等共聚物係以聚羥亞烴之非專屬名稱已知於商業上，所使用之名稱係將數字連結於字尾來命名而個別分辨各個共聚物。聚羥亞烴具有可變化含量之氧化乙烯及氧化丙烯，產生了廣大範圍之化學結構及分子量。一個較佳的聚羥亞烴為聚羥亞烴407，其可取自於例如，美國紐澤西州蒙特奧利微BASF(BASF of Mount Olive)公司商標名為普朗尼F127者。
兩性離子表面活性劑可廣義地說明為那些含有負性及正性兩種電荷基團者。於各種具體例中，其等為脂族季銨，鏻及鋶化合物之衍生物，其中，脂族基團可為約8個碳原子或更多，且宜為8至約18或20個碳原子之直鏈或分支。正性電荷群組典型地為季銨鹽基團，而負性電荷群組一般為陰離子的水溶性基團例如，羧基、磺酸鹽、硫酸鹽、磷酸鹽或膦酸鹽。一個兩性離子表面活性劑之適當實例為4-(N,N-二(2-羥基乙基)-N-十八基銨基)-丁烷-1-羧酸酯。
另一個非-限制性實例為甜菜鹼表面活性劑，例如，那些於美國專利案第5,180,577號中所揭示者，其揭示內容係併入本文中作為參考。較佳之甜菜鹼包括那些由N,N-二甲基甘胺酸所結構性衍生者。其等含有四級氮及被單一亞甲基基團所分離的羧酸酯基團。典型的烷基二甲基甜菜鹼包括癸基甜菜鹼、椰基甜菜鹼、肉豆蔻基甜菜鹼、棕櫚基甜菜鹼、月桂基甜菜鹼、十六基甜菜鹼、硬脂基甜菜鹼等。醯胺基甜菜鹼之非-限制性實例包括椰基醯胺基乙基甜菜鹼、椰基醯胺基丙基甜菜鹼、月桂醯胺基丙基甜菜鹼等。為了闡明，醯胺基丙基甜菜鹼係以下式代表：
其中，RCO代表脂肪酸殘基且R含有約6至24個碳原子或更多，宜為約8至20個碳原子，更佳為約12至18個碳原子。椰基醯胺基丙基甜菜鹼為較佳之市售具體例，其中，RCO係由椰子油所衍生。於一個具體例中，椰基醯胺基丙基甜菜鹼係以約1%之含量存在。
於各種具體例中，表面活性劑係提供適當的起泡性質且親水性-親脂性平衡值(HLB)為至少12。已知於此方面技藝中者，HLB為表面活性劑之親水性及疏水性基團關係之經驗依據的表示法。使用於本發明中較佳之表面活性劑的HLB值為約14-30，更佳為約18-23。然而，應瞭解的是亦可有較高或較低之HLB值以調整各種組成物。
本發明係提供外觀澄清且實質上不含沉澱物之穩定的口腔組成物。於各種具體例中，組成物於溫度約4.4℃(40℉)達至少約29.4℃(85℉)，且更佳達至少100℉之範圍係穩定的。此外，組成物於低溫例如40℉之溶液中宜保持穩定達一段時間，例如12小時或更久。於各種具體例中，組成物進一步含有推進劑氣體例如那些揭示於下列者，及保持低溫穩定性。
已知各種表面活性劑溶液，包括例如，特定非離子性表面活性劑，其於低溫下係穩定的(亦即，可溶)，而於溫度上昇至某一點時趨向混濁。同樣的，於室溫可溶包括例如特定牛磺酸鹽及硫酸鹽之其他表面活性劑，於溫度降低至某一點時會混濁或沉澱。此等沉澱溫度，或濁點為表面活性劑之特點且典型地以ASTM D 2004-65(2003)使用1%表面活性劑水溶液來測定。應瞭解的是沉澱點或濁點亦可在包括那些根據本發明用氟離子來源及其他添加物所調配之其他表面活性劑上測定。濁點係指特別溶液之溶解極限；其係水溶性表面活性劑之水溶液變成混濁之上昇(上限)或降低(下限)溫度。於各種具體例中，組成物具有大於約9.4℃(85℉)，宜大於37.7℃(100℉)之上溶解溫度，或上濁點，及低於約4.4℃(40℉)，宜低於約1.6℃(35℉)之下溶解溫度，或下濁點。
那些於本文中可用之pH調節劑包括降低pH之酸化劑，提高pH之鹼化劑，及控制pH在想要範圍內之緩衝劑。例如，可包括一種或多種選自酸化劑、鹼化劑及緩衝劑之化合物，其提供約2至約6之pH，或於各種具體例中提供約3至約5、約3至約4、及約3.5至約4之pH。任何口腔中可接受之pH調節劑皆可使用，包括但不侷限於羧酸、磷酸及磺酸，酸性鹽類(例如，檸檬酸單鈉、檸檬酸二鈉、蘋果酸單鈉等)、鹼金屬氫氧化物例如氫氧化鈉，碳酸鹽例如碳酸鈉，碳酸氫鹽、倍半碳酸鹽、硼酸鹽、矽酸鹽、磷酸鹽(例如，磷酸單鈉、磷酸三鈉、焦磷酸鹽等)、咪唑及其混合物。可用於本發明操作中之酸化劑包括無機酸例如磷酸、氫氯酸及氫氟酸及有機酸例如蘋果酸、羥基琥珀酸、檸檬酸及酒石酸及其混合物。酸化劑可以約0.5至約3.5重量%範圍之量存在於可起泡沫的組成物中以調整pH至約3至約5間。一種或多種pH調節劑可任意地以有效維持組成物於口腔中可接受之pH範圍內之總量存在。於一個具體例中，蘋果酸係以約3重量%之含量存在。於特定具體例中，緩衝鹽例如磷酸氫鈉係包含於組成物中以抑制牙齒曝露於酸化泡沫時之脫礦質作用。宜提供磷酸氫鈉使得組成物含有約0.1M磷酸鹽離子。於一個具體例中，磷酸氫鈉係以約1.4%(例如，約1.38%)之含量存在。
於特定具體例中，快速崩塌之氟化物牙用泡沫含有甜化劑。可用於本發明中之甜化劑包括於口腔中可接受之天然或人工、營養或非-營養性之甜味劑。此等甜味劑包括葡萄糖、聚右旋糖、蔗糖、麥芽糖、糊精、乾性轉化糖、甘露糖、木糖、核糖、果糖、左旋糖、半乳糖、玉米糖漿(包括高果糖玉米糖漿及玉米糖漿固體)、部分水解的澱粉、經氫化的澱粉水解產物、山梨糖醇、甘露糖醇、木糖醇、麥芽糖醇、異麥芽酮糖醇、阿斯巴甜、紐甜(neotame)、糖精及其鹽類、蔗糖素(sucralose)、以二胜肽為底之強甜味劑(dipeptide-based intense sweetener)、環己基磺醯胺酸鹽、二氫查耳酮(dihydrochalcones)及其混合物。於此等試劑中，糖精鈉可藉目前較佳之一實例而提及。一種或多種甜味劑可強烈地依所選擇之特別甜味劑而任意的以總量存在，但典型地以相對於組成物總重量之約0.005%至約5%，任意地約0.1至約1%，宜於0.25及約0.35%之含量存在。泡沫亦可相對於組成物之總重量以0.01及0.5重量%間之定量含有防腐劑例如，苯甲酸鈉、對-羥基苯甲酸甲酯，對-羥基苯甲酸丙酯等。於一個具體例中，苯甲酸鈉係以約0.1%之含量存在。
相對於從氣溶膠裝置中所噴出之泡沫的總重量，增香物質通常宜以約0.5及約5%間之比例存在於組成物中。那些可用於本文中之增香劑包括任何可用於增強組成物味道之物質或物質的混合物。任何口腔中可接受之天然或合成的增香劑，例如增香油類，增香醛類、酯類、醇類、類似物質、及其組合物皆可使用。增香劑包括香草醛、鼠尾草、黑角蘭、歐芹油、綠薄荷油、桂皮油、鹿蹄草的油(水楊酸甲酯)、歐薄荷油、丁香油、月桂樹油、洋茴香油、桉樹油、柑橘類油、水果油及精油類其包括那些由檸檬、柳橙、萊姆、葡萄柚、杏仁、香蕉、葡萄、蘋果、紅橘、草莓、櫻桃、鳳梨等所衍生者、由豆-及堅果-所衍生之香味劑例如咖啡、可可、可樂、花生、扁桃仁等、吸附性及包膠性增香劑、及其混合物。於口中提供芳香及/或其他感覺效益、包括清涼或溫熱效應之組成份亦涵蓋於本文中之增香劑中。此等組成份包括薄荷醇、醋酸酯、乳酸酯、樟腦、桉樹油、桉樹腦、洋茴香腦、丁香油酚、山扁豆油、歐沙酮(oxxnone)、α-紫羅蘭酮、丙烯基癒瘡木酚(guaiethol)、百里酚、沈香酚、苯甲醛、肉桂醛、N-乙基-對-烷-3-羧胺、N,2,3-三甲基-2-異丙基丁醯胺、3-1-氧基丙烷-1,2-二醇、肉桂醛甘油縮醛(CGA)、薄荷酮(methone)甘油縮醛(MGA)及其混合物。一種或多種增香劑係任意地以約0.01%至約5%，任意地於各種具體例中以約0.05至約2%，且更宜為以約0.1至約1.5%，及以約0.5至約1.5%之總量存在。
包裝本發明之可起泡沫組成物之壓縮氣溶膠容器中所使用之推進劑係選自壓縮空氣，一氧化二氮，及二氧化碳且，更典型地於約20℃具有約15至約80psig，宜約30至約70psig蒸氣壓之揮發性烴或揮發性烴類的混合物(典型地具有3至6個碳原子)中者。揮發性烴一詞亦意欲包括鹵烴類。於特定具體例中，特別佳之推進劑為美國伊利諾州卡那亨市戴佛斯(Diversified)CPC國際公司所製造出售名稱為Aeron A-46("A-46")之商品。A-46係為異丁烷及丙烷之混合物，其於約20℃時具有46psig之蒸氣壓力。於特定具體例中，推進劑包括約75至約85重量%丙烷及約15至約25重量%異-丁烷。於各種具體例中，牙用泡沫組成物包括約5至約20重量%之壓縮液體推進劑，更宜為約7至約10重量%之推進劑。
於各種具體例中，本發明可任意地使用二種推進劑，於此方面技藝中係稱為雙-推進劑系統。揮發性推進劑組份之二種主要的功能為：(1)從分送容器中推動牙膏，及(2)導致分送組成物起泡。於特定具體例中，係使用相同的推進劑組成物於兩種目的上，於其他具體例中則使用不同的推進劑。後者推進劑之功能或可稱為發泡劑，或起泡劑。將發泡劑加至調配物中使調配物起泡，但並不提供用於從其容器中推送牙膏之主要機制能量。
於本文中，可任意使用之泡沫調節劑包括可於攪動組成物(例如，牙膏組成物)時可提高所生成泡沫之量、濃稠度或穩定性的物質。可使用任何口腔中可接受的泡沫調節劑，包括聚乙二醇(PEGs)，亦已知為聚氧化乙烯。高分子量PEGs，包括那些具有平均分子量為約200,000至約7,000,000，例如約500,000至約5,000,000或約1,000,000至約2,500,000者皆適合。一種或多種PEGs係任意地以約0.1%至約10%，更佳為約0.2%至約5%，且甚至更佳為約0.25%至約2%之總量存在。
那些可用於本文中之黏度調節劑包括礦物油，凡士林，黏土及經有機調節之黏土、矽石及其混合物。於各種具體例中，可操作此等黏度調節劑以抑制組成份結合或分離或於攪動液態組成物時用於促進再分散性。一種或多種黏度調節劑係任意地以組成物之約0.01%至約10%間，更佳約0.1%至約5重量%間之總量存在。
那些可任意使用於本文中之著色劑包括顏料，染料，沉澱色料及增添特殊光澤或反射性之試劑例如珠光劑。於各種具體例中，著色劑係可操作而於牙齒的表面上提供白色或淡-色塗層，於已與組成物有效接觸之牙齒表面上用作為位置的指示，及/或用於調整外觀，特別是組成物之顏色及/或不透光度以增進對消費者之吸引力。可使用任何口腔中可接受的著色劑，包括滑石，雲母、碳酸鎂、碳酸鈣、矽酸鎂、矽酸鋁鎂、矽石、二氧化鈦、氧化鋅、紅、黃、褐及黑色氧化鐵、亞鐵氰化鐵銨(ferric ammonium ferrocyanide)、錳紫、群青、鈦酸雲母、氯氧化鉍、FD＆C染料，及其混合物。一種或多種著色劑係任意地以約0.001%至約20%，例如約0.01%至約10%或約0.1%至約5%之總量存在。
本發明之可起泡沫的氟化物組成物係藉著將氟鹽及酸化劑與表面活性劑、甜化劑、香味劑及防腐劑於水溶液中混拌而製備。將預定量含有約85至約98重量%水，及宜約90至約95重量%水之所產生的水溶液加至形成泡沫之容器中。於氣溶膠容器時，將適當的氣溶膠閥安全地固定於容器的開口處。然後經由氣溶膠閥將容器填裝相對於氣溶膠容器所可填充重量之約4%至10%，宜為7%的氣溶膠推進劑。然後將分送促動器及噴口組合固定於閥上。
與雙-推進劑系統一起使用之適當壓力差異分送器係包括那些包含可於含有推進劑液體之堅固容器內配置之含有可崩塌產物之袋，通常稱為袋-於-罐中組合者。如使用此等分送容器之此方面技藝中所已知者，操作手動促動之分送閥讓組成物釋出，而推進劑流體則係藉由流體可滲透的袋與產物分開。流體可滲透之袋系統一般包括由化學惰性聚合物所製成的袋子及那些說明於2003年9月23日頒給巴森(Poisson)等之美國專利案第6,622,943號，及於2004年9月14日頒給奧康諾等之美國專利案第6,789,702號中者。
使用時，係將形成泡沫之容器充分晃動且旋轉以對準牙科器皿溝槽之分送口。將促動器按壓使分送出來之氟化物泡沫的量實質上填滿溝槽的容積。然後將器皿置於患者之口中使得溝槽及其之氟化物泡沫內容物疊置於所要處理之牙齒周圍或鑲合於其內。將氟化物泡沫與牙齒鑲合維持達約1至4分鐘，使氟化物有效的處理牙齒。
溝槽內所形成的泡沫係「鬆軟的」，具有相當輕的形體，與普通的稠密泡沫不同，且容易崩塌以便可以用簡單的抽吸法或用水沖洗口腔而讓殘留的處理泡沫快速且容易地移除。分送中的泡沫，可於崩塌或液化前維持泡沫型式達約2分鐘、約100秒鐘、約90秒鐘。
下列實例可闡明本發明且不能推斷來限制本發明，因為可在不背離其精神及範圍內逕做許多變化。
具有列舉於表1中之組成份之可起泡沫的氟化物處理組成物係藉著將組成份依表列次序於室溫下溶解於水中而製備。
將139.5克處理組成物及10.5克Aeron A-46，80/20異丁烷及丙烷之混合物導入加裝閥及噴嘴之氣溶膠容器中。將組成物置於4.4℃(40℉)之冰箱中達至少12小時，且產生的組成物澄清而不混濁，且無任何可觀察到之沉澱顆粒。從容器中分送出來之牙用泡沫於分送至牙科器皿之溝槽中而與患者之牙齒接觸後1分鐘內崩塌。於泡沫崩塌時，將器皿從患者之口中移開且任何殘留的泡沫係藉著簡單地用水沖洗而由患者之口腔中移除。
具有列舉於表2中之組成份之可起泡沫的氟化物處理組成物係藉著將組成份依前文實例1中所說明的方法於室溫下溶解於水中而製備。然而，於本實例中，係將普朗尼F-127，或無椰基醯胺基丙基甜菜鹼之表面活性劑添加至組成物中。同樣地此組成物係置於4.4℃(40℉)之冰箱中達至少12小時，且產生的組成物澄清而不混濁，且沒有任何可觀察到的沉澱顆粒。
具有列舉於表3中之組成份之可起泡沫的氟化物處理組成物係藉著將組成份藉由前文實例1中所說明的方法於室溫下溶解於水中而製備。然而，於本實例中係將包括月桂基硫酸鈉，且無普朗尼F-127或椰基醯胺基丙基甜菜鹼之表面活性劑添加至組成物中。同樣地該組成物係置於4.4℃(40℉)冰箱中達至少12小時，且產生的組成物混濁，且沒有可觀察到之沉澱顆粒。
Claims (18)
- 一種低密度可起泡沫的口腔照護組成物，其包括含有下列之水溶液：選自由甜菜鹼表面活性劑組成群組之表面活性劑，其中該表面活性係以0.1%至3%重量計之量存在，其以該組成物之總重量計；包含蘋果酸之酸化劑，其量足以調整組成物之pH至3至5，及可釋放氟離子之鹽，其中該可釋放氟離子之鹽係以提供12,000 p.p.m.之量存在，其中當該組成物保存於4.4℃(4()℉)之溫度達12小時，其為澄清且實質上不含沉澱物，其中，當組成物於分送時形成泡沫，其係在小於120秒之時間內崩塌。
- 如申請專利範圍第1項之組成物，其係包裝於形成泡沫之容器中。
- 如申請專利範圍第1項之組成物，其中，當組成物自容器分送出來時形成低密度的泡沫，其實質上於1分鐘或更短的時間內液化。
- 如申請專利範圍第1項之組成物，其中，該表面活性劑係選自椰基醯胺基丙基甜菜鹼。
- 如申請專利範圍第1項之組成物，其中，該可釋放氟離子之鹽為氟化鈉。
- 如申請專利範圍第2項之組成物，其中，該形成泡沫之容器為氣溶膠容器。
- 如申請專利範圍第2項之組成物，其中，該形成泡沫之容器係為袋裝於罐中之組合。
- 如申請專利範圍第6項之組成物，其中，該氣溶膠容器係裝填烴氣體。
- 如申請專利範圍第8項之組成物，其中，該烴氣體包括異丁烷及丙烷之混合物。
- 如申請專利範圍第1項之組成物，其進一步包括聚乙二醇。
- 如申請專利範圍第1項之組成物，其中，該表面活性劑之HLB值大於12。
- 如申請專利範圍第1項之組成物，其中，該表面活性劑之HLB值為18至23。
- 如申請專利範圍第1項之組成物，其進一步包括磷酸氫鈉。
- 一種包裝於形成泡沫之容器中之低密度可起泡沫的牙用氟化物組成物，該組成物包括含有下列之水溶液：水溶性可釋放氟離子之鹽；選自由甜菜鹼表面活性劑組成群組之表面活性劑，其中該表面活性係以0.1%至3%重量計之量存在，其以該組成物之總重量計；及包含蘋果酸之口相容性酸化劑，其量足以調整組 成物之pH至3至5，其中，當組成物自容器分送至牙科器皿之溝槽中時，形成低密度，快速崩塌的泡沫，其實質上於形成泡沫之容器中分送出來且與患者之牙齒接觸後1分鐘內液化，又其中，該組成物於4.4℃(40℉)達至少12小時係穩定及澄清而無沉澱。
- 如申請專利範圍第14項之組成物，其中，該甜菜鹼表面活性劑包括椰基醯胺基丙基甜菜鹼。
- 如申請專利範圍第14項之組成物，其中，該氟化物鹽包括氟化鈉。
- 如申請專利範圍第14項之組成物，其中，該形成泡沫之容器為裝填烴氣體之氣溶膠容器。
- 如申請專利範圍第17項之組成物，其中，該烴氣體包括異丁烷及丙烷之混合物。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/865,457 US8802060B2 (en) | 2007-10-01 | 2007-10-01 | Foamable fluoride oral care composition |
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| Publication Number | Publication Date |
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| TW200920409A TW200920409A (en) | 2009-05-16 |
| TWI411445B true TWI411445B (zh) | 2013-10-11 |
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| TW097137437A TWI411445B (zh) | 2007-10-01 | 2008-09-30 | 可起泡沫的氟化物口腔照護組成物 |
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| US (1) | US8802060B2 (zh) |
| EP (1) | EP2194959B1 (zh) |
| JP (1) | JP5705542B2 (zh) |
| CN (1) | CN101815499B (zh) |
| AR (1) | AR068598A1 (zh) |
| AT (1) | ATE547093T1 (zh) |
| AU (1) | AU2008308948B2 (zh) |
| BR (1) | BRPI0817913B1 (zh) |
| CA (1) | CA2700540C (zh) |
| CO (1) | CO6270242A2 (zh) |
| DK (1) | DK2194959T3 (zh) |
| ES (1) | ES2383038T3 (zh) |
| MX (1) | MX2010003135A (zh) |
| MY (1) | MY153728A (zh) |
| PL (1) | PL2194959T3 (zh) |
| RU (1) | RU2442562C2 (zh) |
| TW (1) | TWI411445B (zh) |
| WO (1) | WO2009045949A2 (zh) |
| ZA (1) | ZA201002224B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH704048A2 (de) | 2010-11-03 | 2012-05-15 | Roland Dr Zettel | Zahnpflegemittel. |
| KR101687405B1 (ko) * | 2010-11-22 | 2016-12-19 | (주)아모레퍼시픽 | 천연 유래 기포제를 함유한 잇몸질환 예방 구강용 조성물 |
| HK1203432A1 (zh) * | 2011-12-20 | 2015-10-30 | Colgate-Palmolive Company | 口腔護理組合物 |
| WO2013192630A1 (en) * | 2012-06-22 | 2013-12-27 | Children Oral Care, Llc | Foaming oral care formulation and system and method of forming and using same |
| RU2523560C1 (ru) * | 2013-02-15 | 2014-07-20 | Закрытое акционерное общество "Брынцалов-А" | Дезинфицрующее антисептическое средство в форме геля для ухода за кожей рук |
| FR3012333B1 (fr) * | 2013-10-24 | 2015-11-13 | Ouali Razira | Dentifrice liquide comprenant un hydrolisat de feuilles de chicoree, notamment au stade d'endive |
| CN104721063B (zh) | 2013-12-19 | 2018-05-08 | 高露洁-棕榄公司 | 包含氧化锌和柠檬酸锌的洁齿剂组合物 |
| NO339503B1 (no) * | 2014-06-18 | 2016-12-19 | Meda Otc Ab | Sammensetning for forebygging eller behandling av dental erosjon |
| GB201811061D0 (en) | 2018-07-05 | 2018-08-22 | GlaxoSmithKline Consumer Healthcare UK IP Ltd | Novel composition |
| US20220175642A1 (en) * | 2019-04-29 | 2022-06-09 | Hidetoshi Nishio | Tooth whitening method |
| CN110946319A (zh) * | 2019-11-20 | 2020-04-03 | 许达勇 | 一种烟碱推进剂及其制备方法 |
| CN110859765A (zh) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | 一种防龋氟化泡沫 |
| US20220264887A1 (en) * | 2020-12-30 | 2022-08-25 | The Trustees Of Columbia University In The City Of New York | Foam Formulations For Decontamination Of Surfaces With Minimum Wastewater |
| WO2025080745A1 (en) * | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
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- 2008-09-29 MY MYPI2010001218A patent/MY153728A/en unknown
- 2008-09-29 BR BRPI0817913A patent/BRPI0817913B1/pt not_active IP Right Cessation
- 2008-09-29 JP JP2010528050A patent/JP5705542B2/ja not_active Expired - Fee Related
- 2008-09-29 ES ES08834922T patent/ES2383038T3/es active Active
- 2008-09-29 MX MX2010003135A patent/MX2010003135A/es active IP Right Grant
- 2008-09-29 AT AT08834922T patent/ATE547093T1/de active
- 2008-09-29 CA CA2700540A patent/CA2700540C/en not_active Expired - Fee Related
- 2008-09-29 CN CN200880110003.3A patent/CN101815499B/zh not_active Expired - Fee Related
- 2008-09-29 RU RU2010117170/15A patent/RU2442562C2/ru not_active IP Right Cessation
- 2008-09-29 EP EP08834922A patent/EP2194959B1/en not_active Not-in-force
- 2008-09-29 PL PL08834922T patent/PL2194959T3/pl unknown
- 2008-09-29 DK DK08834922.0T patent/DK2194959T3/da active
- 2008-09-29 AU AU2008308948A patent/AU2008308948B2/en not_active Ceased
- 2008-09-29 WO PCT/US2008/078091 patent/WO2009045949A2/en not_active Ceased
- 2008-09-30 AR ARP080104276A patent/AR068598A1/es unknown
- 2008-09-30 TW TW097137437A patent/TWI411445B/zh not_active IP Right Cessation
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- 2010-03-29 ZA ZA2010/02224A patent/ZA201002224B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2010117170A (ru) | 2011-11-10 |
| AU2008308948A1 (en) | 2009-04-09 |
| RU2442562C2 (ru) | 2012-02-20 |
| ATE547093T1 (de) | 2012-03-15 |
| JP5705542B2 (ja) | 2015-04-22 |
| HK1143533A1 (zh) | 2011-01-07 |
| CN101815499B (zh) | 2015-09-02 |
| BRPI0817913A2 (pt) | 2014-10-07 |
| TW200920409A (en) | 2009-05-16 |
| ZA201002224B (en) | 2013-03-27 |
| US20090087391A1 (en) | 2009-04-02 |
| DK2194959T3 (da) | 2012-06-25 |
| WO2009045949A2 (en) | 2009-04-09 |
| CN101815499A (zh) | 2010-08-25 |
| CA2700540C (en) | 2013-08-27 |
| EP2194959B1 (en) | 2012-02-29 |
| AR068598A1 (es) | 2009-11-18 |
| EP2194959A2 (en) | 2010-06-16 |
| WO2009045949A3 (en) | 2009-06-18 |
| PL2194959T3 (pl) | 2012-08-31 |
| ES2383038T3 (es) | 2012-06-15 |
| BRPI0817913B1 (pt) | 2016-10-11 |
| AU2008308948B2 (en) | 2012-07-05 |
| US8802060B2 (en) | 2014-08-12 |
| CO6270242A2 (es) | 2011-04-20 |
| JP2010540645A (ja) | 2010-12-24 |
| CA2700540A1 (en) | 2009-04-09 |
| MY153728A (en) | 2015-03-13 |
| MX2010003135A (es) | 2010-04-07 |
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