TWI400042B - Food tablet - Google Patents

Description

Food lozenge

The present invention relates to a food lozenge, and more particularly to a food lozenge for releasing the target ingredients at different rates.

Because of the advantages of convenient dosage and easy storage, the tablet dosage is quite common for oral administration. In general, a lozenge usually only has a single purpose effect, so if a variety of effects are required, the user will need to take a variety of lozenges. In addition, depending on the needs, immediate lozenges and long-acting lozenges have also been developed and used in the pharmaceutical field.

However, the application of the above-mentioned tablets is not common in the food field. For example, one conventional method of controlling body weight is to take a tablet that provides satiety before meals to reduce the amount of food, and to take a tablet that promotes metabolism after meals to increase calorie expenditure. For consumers, it is not convenient to use.

In summary, how to achieve the different purposes and effects required with a single food lozenge is the goal that is currently in great demand.

In view of the above problems, it is an object of the present invention to provide a food lozenge which combines rapid disintegration and delayed release techniques to release target ingredients at different rates.

In order to achieve the above object, a food tablet according to an embodiment of the present invention is used to release a target ingredient at a different rate, and comprises a first layer tablet and a second layer tablet. The first tablet comprises a first active ingredient, a first controlled release agent and a first excipient; the second layer of the tablet comprises a second active ingredient, a second controlled release agent and a second shaped form The agent, wherein, when the food tablet is consumed by a user, the first layer of the tablet disintegrates within a predetermined time to release the first active ingredient, and the second layer of tablet continues to release the second active ingredient More than the predetermined time mentioned above.

The purpose, technical contents, features, and effects achieved by the present invention will become more apparent from the detailed description of the appended claims.

A food lozenge according to a preferred embodiment of the invention is used to release the target ingredients at different rates. The food tablet of the present invention comprises a first layer tablet and a second layer tablet, wherein the first layer tablet comprises a first active ingredient, a first controlled release agent and a first excipient, and second The tablet comprises a second active ingredient, a second controlled release agent, and a second excipient. With the rapid disintegration formulation, the first layer of tablet is disintegrated within a predetermined time to release the first component after being consumed by the user. In addition, the delayed release formulation is also utilized to allow the second layer of tablet to sustain release of the second component for a sustained release time greater than the predetermined time for disintegration of the first layer of tablet.

In one embodiment, after the food tablet of the present invention is consumed, the first layer of the tablet has the effect of a fast disintegrating formulation to release the first active ingredient. For example, the first controlled release agent comprises microcrystalline α-cellulose, croscarmellose sodium, and sodium carboxymethyl starch, preferably, crystalline α-cellulose, crosslinked carboxymethyl fiber The sodium and sodium carboxymethyl starch accounted for 10 to 30%, 2 to 4%, and 2 to 4%, respectively, of the first layer of the tablet. In an embodiment, the first controlled release agent may further comprise alginic acid.

Following the above description, the second layer of the tablet uses a delayed release technique, and the effect of delaying the release can be achieved by coating the second active ingredient in the particles; or by adding a wetting agent to make the second layer of the tablet. A monohydrate layer is formed in the aqueous solution by the barrier of the hydration layer to extend the time during which the second active ingredient is released to the aqueous solution. For example, the second controlled release agent can be a hydrosol. In one embodiment, the hydrosol may be hydroxypropyl methylcellulose, such as hydroxypropylmethyl having a hydroxypropyl group content of 7 to 12%, a methyl group content of 19 to 24%, and a viscosity of 4000 to 15000 cP. Cellulose, preferably, hydroxypropyl methylcellulose comprises from 10% to 30% by weight of the second layer of tablet.

The first excipient primarily comprises a hydrophobic diluent, for example the hydrophobic diluent can be corn starch, pregelatinized starch, dibasic calcium phosphate, dicalcium phosphate or a combination thereof. The second excipient primarily comprises a hydrophilic diluent, for example the hydrophilic diluent can be isomalt, mannitol, xylitol, maltose, lactose, maltodextrin, sucrose, glucose or a combination thereof.

Further, the first excipient and the second excipient may further comprise a lubricant, a binder, a flow control agent, a pigment, an emulsifier, or a combination thereof. For example, the lubricant may be magnesium stearate, calcium stearate, polyethylene glycol or a combination thereof; the binder may be polyvinylpyrrolidone, starch, dextrin, methylcellulose or a combination thereof; The controlling agent may be ceria, talc, sodium strontium aluminate or a combination thereof; the pigment may be a natural pigment or an artificial food coloring.

The food tablet of the preferred embodiment of the present invention, wherein the first active ingredient may be an ingredient having the function of absorbing oil in the digestive tract of the user and/or providing a feeling of satiety of the user, such as chitin, plant cellulose or the like. The combination, and the second active ingredient may be a component having an effect of promoting decomposition and metabolic rate of the oil of the user, such as Guarana extraction, or an ingredient having an effect of inhibiting a lipid or carbohydrate metabolic pathway, such as Garcinia Cambogia, Soy peptides, stalks, green coffee beans, and purple rice extracts are also combinations of the above two effects. In this way, the user only needs to take the food tablet of the present invention before eating, thereby producing a feeling of satiety and absorbing the fat which is ingested after eating, and has an effect of promoting metabolism or inhibiting metabolism of lipids or sugars for a long period of time. It should be noted that the above embodiment is described by having different effects of the first active ingredient and the second active ingredient, however, the food tablet of the present invention is not excluded from being applied to the first active ingredient having the same efficacy and the second effective Ingredients, or a mixture of active ingredients.

Two example formulations are disclosed below which are subjected to a tableting process to form a food lozenge of the present invention.

Example 1:

Example 2:

In summary, the food tablet according to the present invention combines the instant disintegration of rapid disintegration with the long-acting effect of delayed release in a single tablet, which can be used in various applications in the food field, for example, as a meal replacement meal, etc. It can enhance the convenience of users.

The embodiments described above are only intended to illustrate the technical idea and the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the contents of the present invention and to implement the present invention. That is, the equivalent variations or modifications made by the spirit of the present invention should still be included in the scope of the present invention.

Claims (11)

A food lozenge for controlling body weight, the food lozenge comprising: a first layer of lozenge comprising: a first active ingredient, which is chitin, plant cellulose or a combination thereof; a first control a release agent, the first controlled release agent comprising microcrystalline α -cellulose, croscarmellose sodium, and sodium carboxymethyl starch, wherein the microcrystalline α -cellulose, the crosslinked carboxymethyl fiber The sodium sodium and the sodium carboxymethyl starch account for 10 to 30%, 2 to 4%, and 2 to 4%, respectively, of the first layer of the tablet; and a first excipient; and a second a tableting agent comprising: a second active ingredient, which is a Guarana extract, a Garcinia Cambogia, a soybean peptide, a bootie leaf, a green coffee bean, a purple rice extract or a combination thereof; a second controlled release agent , comprising hydroxypropyl methylcellulose in an amount of 10 to 30% by weight of the second layer of the tablet; and a second excipient; wherein, after the food tablet is consumed by a user Dissolving the first layer of tableting agent for a predetermined period of time to release the first active ingredient, and the second layer of tableting agent continues The time for releasing the second active ingredient is greater than the predetermined time. The food lozenge of claim 1, wherein the first excipient is a hydrophobic diluent. The food lozenge of claim 2, wherein the hydrophobic diluent is corn starch, pregelatinized starch, calcium hydrogen phosphate, dicalcium phosphate or a combination thereof. The food tablet according to any one of claims 1 to 3, wherein the hydroxypropylmethylcellulose has a hydroxypropyl group content of 7 to 12%, a methyl group content of 19 to 24%, and a viscosity of 4000 to 4,000. 15000 cP. The food lozenge of claim 1, wherein the second excipient is a hydrophilic diluent. The food lozenge of claim 5, wherein the hydrophilic diluent is isomalt, mannitol, xylitol, maltose, lactose, maltodextrin, sucrose, glucose or a combination thereof. The food tablet according to claim 1, wherein the first excipient is a lubricant, a binder, a flow control agent, a pigment, an emulsifier or a combination thereof; the second excipient is a lubricant or a binder , a flow control agent, a pigment, an emulsifier or a combination of the above. The food lozenge of claim 7, wherein the lubricant is magnesium stearate, calcium stearate, polyethylene glycol or a combination thereof. The food lozenge of claim 7, wherein the binder is polyvinylpyrrolidone, starch, dextrin, methylcellulose or a combination thereof. The food lozenge of claim 7, wherein the flow control agent is ceria, talc, sodium strontium aluminate or a combination thereof. The food lozenge of claim 7, wherein the pigment is a natural pigment or an artificial food coloring.