TWI458500B - 口腔保健組成物及方法 - Google Patents
口腔保健組成物及方法 Download PDFInfo
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- TWI458500B TWI458500B TW100121917A TW100121917A TWI458500B TW I458500 B TWI458500 B TW I458500B TW 100121917 A TW100121917 A TW 100121917A TW 100121917 A TW100121917 A TW 100121917A TW I458500 B TWI458500 B TW I458500B
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Description
本發明一般係關於有用於提高口腔衛生之口腔組成物，且較特別地係關於含有蔓越莓萃出物非透析性物質(NDM)的增強抗牙菌斑效力之口腔組成物。
細菌對彼此間以及對口腔表面之吸附為導致牙菌斑以及齲齒及牙周病的主要因素之一。因此，具有可阻斷微生物吸附及聚集之抗聚集化合物係有助益。
蔓越莓萃出物非透析性物質(NDM)為高分子量的物質，其係由蔓越莓汁所衍生，如說明於歐飛克,I.，歌德哈J.及沙倫N.，蔓越莓及藍莓汁之抗-大腸桿菌吸附活性，Adv. Exp. Med. Biol
. 1996；408：179-183中者，及於美國專利案號6,303,125及6,843,993中者，各專利案之全部內容係合併於本文中作為參考。
美國專利案號5683678，其揭示內容完全合併於本文中作為參考，係揭示由蔓越莓單離出來之花青苷。韋斯,E.，里夫-朵,R.，卡沙曼,Y.，歌德哈,J.，沙隆,N.及歐飛克,I.，JADA
，129，1719(1998)係揭示藉由蔓越莓萃出物NDM來抑制大比例之牙菌斑細菌的共聚集。韋斯等亦揭示於試管內分析來試驗蔓越莓NDM對於抑制或反轉共聚集的能力。
美國專利案號5840322、6303125及6843993，其揭示內容完全合併於本文中作為參考，係揭示包含蔓越莓萃出物NDM之口腔組成物，其於試管內分析中以1250微克/毫升之濃度反轉共聚集。發現蔓越莓萃出物NDM漱口水可降低總細菌計數。然而，於檢測蔓越莓萃出物NDM漱口水效果之臨床試驗中觀察到牙菌斑及牙齦之指數沒有改變，且該結果上並未提出超越標準漱口水之任何臨床優點。韋斯,E.，柯滋洛夫斯基,A.，史代柏格,D.，里夫-朵,R.，葛林斯坦,R.，費德曼,M.，沙隆,N.及歐飛克,I.，FEMS微生物學手札(FEMS Microbiology Letters
) 232，(2004)，89-92頁。
此方面之技藝中需要提供能夠抑制細菌共聚集且降低牙菌斑累積之口腔保健組成物。
於第一個觀點中，本發明係提供包含蔓越莓萃出物非透析性物質及口腔上可接受之媒劑的口腔保健組成物，其中蔓越莓萃出物非透析性物質係以有效抑制細菌共聚集之量存在。較佳為該口腔保健組成物不包含去活化蔓越莓萃出物非透析性物質之成份或組份。於另一個觀點中，本發明係提供於口腔中抑制細菌共聚集的方法，其包括將包含口腔上可接受的媒劑的口腔保健組成物施用至口腔，其中含有有效抑制細菌共聚集之蔓越莓萃出物非透析性物質之量。
應瞭解詳細的說明及特定之實例於指明本發明之具體例時，其僅係為了闡明的目的且並非意欲限制本發明之範圍。
於回顧本文中所述之本發明的說明時必需考慮下列之定義及非限制性的指南。本文中所用之標題(如"序論"及"摘要")及副標題(如"組成物"及"方法")意欲僅用於本發明揭示內容範圍內之主題的一般架構，且並非用來限制本發明之揭示內容或其任何觀點。特別是，於"序論"中所揭示之主題可包括本發明範圍內之技術觀點，且不可構成引證先前技藝。於"摘要"中所揭示之主題並非是本發明全部範圍之詳盡或完整的揭示內容或其任何具體例。於本說明書章節內之物質分類或討論如具有特別效用(例如，如為"活性"或"載體"組成份)係為了方便而做，且不應推斷為當該物質使用於任何給定之組成物中時其必須或僅能根據本文中其之分類而作用。
本文中參考資料之引述不對那些參考資料為先前技藝或對本文中所揭示之發明的可專利性具有任何相關性作承諾。於序論中所引用之參考資料內容的任何討論僅為了提供參考資料之作者所做的主張之概述，且不對此等參考內容之正確性作承諾。
本案說明書及特定實例於指明本發明之具體例時，其僅係為了闡明的目的且並非意欲用來限制本發明之範圍。再者，列舉具有所述特色之複數具體例並非意欲排除具有另外特色之其他具體例，或所述特色併入不同組合之其他具體例。特定實例係為了闡明如何製造及使用本發明之組成物及方法之目的而提供，除非另有明確的說明，其並非意欲代表本發明已經、或尚未製造或試驗之給定的具體例。
本文中所用之"較佳的"及"較佳地"一詞係指於本發明的具體例於特定環境下提供特定的利益。然而，其他具體例，於相同或其他情況下，亦可為較佳者。再者，詳述一種或多種較佳之具體例並非意指不可使用其他具體例，且並非意欲將其他具體例從本發明之範圍中排除。此外，該組成物及方法可包含，主要包括，或包括其中所說明之元素。
本文中所用之"包含"及其之變化例一詞意欲為非限制性者，如此詳述清單中之項目不是不包含其他亦可於本發明之物質、組成物、裝置及方法中使用的同類項目。
本說明書及申請專利範圍全文中揭示之特定數值(例如，溫度、組份之重量百分比等)意指數值、加或減額外的值，一般精於此方面技藝之人士應瞭解其係依典型地與該數值相關之測定誤差的變數及程度而定。例如，一般精於此方面技藝之人士應瞭解給定溫度應包括測定溫度之儀器所給定者之至多10%變化性。
“共聚集”表示法係指二種或多種細菌，包括不同種類之細菌的聚集/吸附，且共聚集或吸附之抑制作用一般係指預防細菌起始吸附或聚集。
本發明之組成物抑制一種或多種選自於口腔鏈球菌(Streptococcus oralis
)、有核梭桿菌(Fusobacterium nucleatum
)、內氏放線菌(Actinomyces maeslundii
)、黏性放線菌(A. viscosus
)及變異鏈球菌(S. mutan
)之細菌共聚集。其他細菌可於口腔中共聚集者亦在本發明之範圍內。
於抑制細菌共聚集之方法中，本發明之組成物其可構成漱口劑、牙膏、牙霜(dental cream)或牙膠、或牙粉的整體部份且於一般刷牙時施用，或該組成物可經調配及包裝為分開的處理且於一般刷牙之前、後、及/或之間分開施用。所施用之組成物可藉由刷牙、漱口、咀嚼，及用已知於此方面技藝中之其他方式施用。
於具體例中，本發明係提供包含蔓越莓萃出物非透析性物質及口腔上可接受之媒劑的口腔保健組成物，其中，該蔓越莓萃出物非透析性物質係以有效抑制細菌共聚集之量存在。於另一個觀點中，蔓越莓萃出物NDM係以有效抑制及/或預防細菌於口腔中共聚集的量存在於組成物中。較佳為，蔓越莓萃出物NDM係以適於預防或治療由細菌共聚集所引起之症狀，如選自於牙菌斑、蛀牙、口臭、牙周病及牙齦炎之症狀的量存在。該蔓越莓萃出物非透析性物質係以0.08-1.33毫克/毫升之濃度存在於組成物中為有利。於較佳之具體例中，蔓越莓萃出物非透析性物質宜以約0.3重量%之濃度存在。
根據本發明之組成物於口腔中抑制細菌之共聚集。標準口腔組成物配劑之組份可干擾蔓越莓萃出物NDM抑制細菌共聚集之效應。某些此等組份可去活化蔓越莓萃出物NDM，且因此，雖然某些文獻業已揭示使用具有抗細菌效益之蔓越莓萃出物NDM，當經試驗時，該組成物與未含蔓越莓萃出物NDM之標準漱口水配劑相較時，其事實上並未提供任何改善的效益。本案發明者發現一些組成份可去活化蔓越莓萃出物NDM。因此，本發明之較佳具體例係提供不包含可去活化蔓越莓萃出物NDM之組份的組成物。本案發明者業已令人驚奇地發現包含蔓越莓萃出物NDM之組成物，其有效地抑制細菌共聚集且不干擾蔓越莓萃出物NDM之活性。
本案發明者業已發現包含蔓越莓萃出物非透析性物質之組成物於口腔細菌之共聚集上具有抑制的效應。其發現標準口腔組成物之特定組份可降低蔓越莓萃出物非透析性物質抑制細菌共聚集的能力，使其於降低細菌之生長上無效。雖然不想被任何操作理論所束縛，本案發明者發現包含表面活化劑之口腔組成物可抑制蔓越莓萃出物非透析性物質於抑制細菌共聚集的能力。特定地，表面活化劑如羥乙烯烴丙烯聚合體(poloxamers)係抑制蔓越莓萃出物NDM之活性。其他組份如特定之增香劑及特定之精油以習用量呈現。此等組份可使用於本發明之內文中，但其量比典型地使用於漱口水配劑中者低。一般精於此方面技藝之人士使用本文中所提供之準則指南可容易地決定常用於漱口水配劑中抑制或干擾蔓越莓萃出物NDM活性之組成份(及其等之個別濃度)。
於具體例中，口腔上可接受的媒劑為水、醇及一種或多種濕潤劑之組合。於較佳之具體例中，醇為乙醇。口腔組成物亦宜包括一種或多種選自於山梨糖醇及甘油，及其組合之濕潤劑。
根據本發明之組成物亦可包含一種或多種其他試劑，其典型地選自於抗牙菌斑劑、增白劑、抗細菌劑、洗淨劑、香味劑、甜化劑、吸附劑、表面活化劑、泡沫調節劑、研磨劑類、pH調整劑、濕潤劑、口感劑、著色劑、研磨劑、酒石控制(抗結石)劑、氟化物離子來源、唾液刺激劑、營養物及其組合。可添加至組成物之各種組份包括，例如，甜化劑如糖精，或糖精鈉、醇類如乙醇、氟化物離子來源如氟化鈉，以及甘油、山梨糖醇、丙二醇、聚乙二醇、烷基聚配糖物(APG)、聚山梨糖醇酸酯、PEG40、蓖麻油、薄荷醇等。
那些可用於本文中之增香劑包括可操作來增強組成物味道之任何物質或物質的混合物。任何口腔上可接受之天然及合成的增香劑，如增香油類、增香醛類、酯類、醇類、類似物質，及其組合皆可使用。增香劑包括香草醛、鼠尾草、黑角蘭、歐芹油、綠薄荷油、桂皮油、鹿蹄草的油(水楊酸甲酯)、歐薄荷油、丁香油、月桂樹油、茴香油、桉樹油、柑橘類油、果實油(fruit oils)及香精包括那些從檸檬、柳橙、萊姆、葡萄柚、杏桃、香蕉、葡萄、蘋果、草莓、櫻桃、鳳梨等所導生者，由豆-及堅果-所導生之香味如咖啡、可可、可樂、花生、扁桃仁等，吸附性及包膠性增香劑，及其混合物。亦涵蓋於本文中之增香劑為於口中提供芳香及/或其他感覺效果，包括清涼或溫熱效果的組成份。此等組成份包括薄荷醇、醋酸酯、乳酸酯、樟腦、桉樹油、桉樹腦、洋茴香腦、丁子香酚、山扁豆油、歐沙酮(oxanone)、[α]-紫羅蘭酮、丙烯基癒瘡木酚(propenyl guaiethol)、百里酚、沈香酚、苯甲醛、肉桂醛、N-乙基-對-烷-3-羧胺、N,2,3-三甲基-2-異丙基丁醯胺、3-1-氧基丙烷-1,2-二醇、肉桂醛甘油縮醛(CGA)、薄荷酮(methone)甘油縮醛(MGA)，及其混合物。一種或多種增香劑係任意以約0.01%至約5%，任意於各種具體例中由約0.05至約2%，由約0.1%至約2.5%，及由約0.1至約0.5%之總量存在。
那些可用於本文中之甜化劑包括右旋糖、多右旋糖、蔗糖、麥芽糖、糊精、乾的轉化糖、甘露糖、木糖、核糖、果糖、左旋糖、半乳糖、玉米糖漿、部份水解的澱粉、氫化的澱粉水解產物、山梨糖醇、甘露糖醇、木糖醇、麥芽糖醇、異麥芽酮糖醇、阿斯巴甜、紐甜(neotame)、糖精及其鹽、蔗糖素(sucralose)、以二胜肽為底之強甜味劑、環己基磺醯胺酸鹽(cyclamates)、二氫查耳酮(dihydrochalcones)，及其混合物。
口感劑包括於使用組成物時授予想要之質地或其他感覺的物質。此等可包括經設計用攪動即分裂之膠凝的矽石顆粒，如SORBOSILBFG系列，(例如，BFG 10、BFG 50、BFG 100等)、CBT60S、CBT70，或AC33/43矽石，市售可得自於PQ公司，Valley Forge，賓夕法尼亞州。
那些可用於本文中之著色劑包括顏料、染料、沉澱色料及增添特別光澤或反射性之試劑如珠光劑。於各種具體例中，著色劑係可操作而於牙齒的表面上提供白色或淡-色塗層，於已與組成物有效接觸之牙齒的表面上用作為位置的指示劑，及/或用於調整外觀，特別是組成物之顏色及/或不透光度以提高對消費者之吸引力。任何口腔上可接受的著色劑，包括FD&C染料及顏料、滑石、雲母、碳酸鎂、碳酸鈣、矽酸鎂、矽酸鋁鎂、矽石、二氧化鈦、氧化鋅、紅，黃，褐及黑色氧化鐵，氰亞鐵酸鐵銨(ferric ammonium ferrocyanide)、錳紫(manganese violet)、群青、鈦酸雲母、氯氧化鉍，及其混合物皆可使用。一種或多種著色劑係任意以約0.001%至約20%之總量存在，例如約0.01%至約10%或約0.1%至約5%。
本發明之組成物可進一步包含任意的研磨劑，其可例如，用作為磨光劑。任何口腔上可接受的研磨劑皆可使用，但研磨劑之類型、顆粒大小及量應予以選擇以便牙齒琺瑯質於該組成物之正常使用中不會過度磨損。適當之任意研磨劑包括矽石，例如為沉澱之矽石型式或如與礬土、不溶性磷酸鹽、碳酸鈣，及其混合物摻合者。不溶性磷酸鹽之中可用作為研磨劑者為正磷酸鹽，聚偏磷酸鹽及焦磷酸鹽。闡明之實例為正磷酸二鈣二水合物、焦磷酸鈣、焦磷酸鈣、磷酸三鈣、聚偏磷酸鈣及不溶性聚偏磷酸鈉。
本發明之組成物任意包含酒石控制(抗結石)劑。那些可用於本文中之酒石控制劑包括任何此等試劑的鹽，例如其等之鹼金屬及銨鹽：磷酸鹽及聚磷酸鹽(例如焦磷酸)、聚胺基丙烷磺酸(AMPS)、聚烯磺酸鹽、聚烯磷酸鹽、二膦酸鹽如氮雜環烷-2,2-二膦酸鹽(例如，氮雜環庚烷-2,2-二膦酸)、N-甲基氮雜環戊烷-2,3-二膦酸、乙烷-1-羥基-1,1-二膦酸(EHDP)及乙烷-1-胺基-1,1-二膦酸鹽、膦酸基烷羧酸及有用的無機磷酸鹽及聚磷酸鹽包括一代、二代及三代的磷酸鈉、三聚磷酸鈉、四聚磷酸鹽，一-、二-、三-及四鈉焦磷酸鹽、三偏磷酸鈉、六偏磷酸鈉及其混合物。
本發明之組成物任意包含氟化物離子來源且可用作為，例如，抗齲齒劑。任何口腔上可接受的微粒氟化物離子來源皆可使用，包括氟化鉀、氟化鈉及氟化銨及一氟磷酸鹽、亞錫氟化物、氟化銦、氟化胺如歐拉氟(olaflur)(N'-十八基三亞甲基二胺-N,N,N'-三(2-乙醇)-氟化二氫)，及其混合物。一種或多種氟化物離子來源係任意以提供臨床上有效量可溶性氟化物離子至口腔組成物之量存在。
本發明之組成物任意包含唾液刺激劑可用於，例如，改善口乾。任何口腔上可接受的唾液刺激劑皆可使用，包括無需限制食品酸類如檸檬酸、乳酸、蘋果酸、琥珀酸、抗壞血酸、己二酸、反式丁烯二酸及酒石酸，及其混合物。一種或多種唾液刺激劑係任意存在於唾液刺激有效總量中。
本發明之組成物任意包含營養物。適當之營養物包括維生素、礦物質、胺基酸，及其混合物。維生素包括維生素C及D、硫胺素、核黃素、泛酸鈣、菸鹼酸、葉酸、菸草醯胺、吡哆醇、氰鈷胺、對-胺基苯甲酸、類生物黃鹼素(bioflavonoids)，及其混合物。營養添加物包括胺基酸(如L-色胺酸、L-離胺酸、甲硫胺酸、蘇胺酸、左旋肉毒鹼(levocarnitine)及L-肉毒鹼)、肝營養素(Lipotropics)(如膽汁素、肌醇、甜菜鹼，及亞麻油酸)，及其混合物。
於各種具體例中，根據本發明之口腔組成物並非有意用於吞嚥，而是於口腔中停留一段足以影響所意欲效用的時間。於其他可攜式具體例中(如錠片、薄荷糖、小球體、扁片、來自可攜式小噴霧器經調配之液體用於口腔施用、來自可攜式小滴瓶經調配之液體用於口腔施用、或軟韌性錠劑)，該口腔組成物可於任意停留於口腔中一段足以影響所意欲之效用後吞嚥。
各種具體例之口腔保健組成物宜為潔牙劑的型式。本說明書全文中所用之“潔牙劑”一詞係表示糊膏、凝膠，或液態配劑。潔牙劑可為任何想要的型式，如牙膏；(包括深條紋、表面條紋、多層、含凝膠圍繞的糊膏)；粉末；小球體；漱口水；漱口劑；錠片；牙齒凝膠；牙周凝膠；適於塗搽牙齒表面的液體；口香糖；可溶、部份可溶或不可溶性薄膜或細條；扁片；擦拭紙或濕紙巾；植入物；泡沫體；片劑；牙線，含有經調配用於口腔施用之液體於可攜式噴霧器中(噴霧瓶)，含有經調配用於口腔施用之液體於可攜式小滴瓶中，軟韌性錠劑("chewie(嚼易)")，或其任何組合。本文中所用之"口腔上可接受的載體"係指使用於本發明之組成物中安全無虞，具同等合理利益/風險比例之物質或物質組合。
本發明內文中所用之“口腔上可接受的媒劑”或“口腔上可接受的載體”表示法係指可用於調配如上所說明之任何潔牙劑的任何媒劑。適當之口腔上可接受的媒劑包括，例如，一種或多種下列者：溶劑、鹼性試劑、濕潤劑、增稠劑、表面活化劑、研磨劑、抗結石劑、著色劑、香味劑、染料、含鉀的鹽、抗細菌劑、去敏感劑、染色還原劑，及其混合物。
本發明亦提供可攜式劑量物品，其包含定義如前之口腔保健組成物，其中，該可攜式劑量物品係選自於錠片、薄荷糖、小球體、扁片、含有該摻合物於調配液體中用於口腔施用之可攜式小噴霧器作為噴霧劑、含有該摻合物於調配液體中用於口腔施用之可攜式小瓶中作為滴劑，及軟韌性錠劑。
較佳者，因此可用於本發明中之特定物質及組成物為製藥上或化妝品上可接受，臨床上有效(effective)，及/或臨床上有功效(efficacious)者。本文中所用之如"製藥上可接受"或"化妝品上可接受"，"臨床上有效"，及/或"臨床上有功效"之組份為一種適用於人類及/或動物且係以適當量提供(臨床上有效的量)以提供想要的治療、預防、感覺、裝飾或化妝利益無不當不利的副作用(如毒性、刺激性及過敏性反應)而具同等合理利益/風險比例者。
該蔓越莓萃出物非透析性物質(NDM)係由蔓越莓汁濃縮物所衍生。蔓越莓汁含有抑制細菌吸附之高分子量物質(NDM)以寄主細胞以及許多口腔細菌之共聚集。該蔓越莓萃出物NDM係根據韋斯,E；里夫-朵,R.；卡沙曼(Kashmamn),Y.；歌德哈,J.；沙隆,N.；歐飛克，依查哈克，美國牙醫協會期刊(J. Am. Dent. Assoc
.) 129，1719(1998)所說明的方法製備。
根據本發明之組成物可給藥至或施用於人類或其他動物個體。該組成物可適合給藥或施用於人類或動物個體之口腔用來抑制細菌之共聚集。因此，本發明係提供定義如前之組成物用作為醫藥品或化妝劑。
本發明亦提供包含蔓越莓萃出物非透析性物質及口腔上可接受之媒劑的口腔保健組成物，其中，該蔓越莓萃出物非透析性物質係以有效抑制細菌共聚集之量存在。本發明亦提供於口腔中抑制細菌共聚集的方法，其包括將包含口腔上可接受的媒劑的口腔保健組成物施用於口腔，其中含有有效抑制細菌共聚集量之蔓越莓萃出物非透析性物質。
包含蔓越莓萃出物NDM及口腔上可接受之媒劑的組成物亦能明顯地抑制細菌之共聚集。該組成物特別有用於口腔中抑制細菌之共聚集。包含根據本發明之組成物的醫藥品可給藥至病患。
本文中所引用之各個及每一個參考的全部內容係合併於本文中作為參考。現在將參考下列非限制性的實例來說明各種具體例。
該蔓越莓萃出物NDM係根據韋斯等美國牙醫協會期刊(J. Am. Dent. Assoc
.) 129(12)，1719(1998)所說明的方法製備。該蔓越莓萃出物NDM係藉著將蔓越莓汁經由高分子量切開式透析袋予以透析而得到。餘留在袋中未透析出來之物質為非透析性物質(NDM)。將該蔓越莓萃出物NDM調配於漱口水組成物中(顯示於表1中)。
於試管內分析顯示出蔓越莓萃出物NDM漱口水當稀釋8倍時對抗血鏈球菌(S. sangius
)及有核梭桿菌(F. nucleatum
)細菌配對之共聚集具功效。
於試管內分析亦顯示此漱口水當稀釋25倍時於黏性放線菌(A. viscosus
)之生長上具抑制效力(表4及表5)。
於試管內分析顯示表2中所顯示之漱口水配劑未有效地抑制細菌之共聚集。因此，羥乙烯烴丙烯聚合體(poloxamer)之存在可抑制或干擾蔓越莓萃出物NDM之活性。一般精於此方面技藝之人士可容易地試驗其他組份及其等之個別數量，使用上述實驗方法來確定其他常用於漱口水配劑中抑制或者干擾蔓越莓萃出物NDM之活性的組份。
抗共聚集分析之特定實驗方法係說明於韋斯EI，里夫-朵R，卡沙曼Y，歌德哈J，沙隆N，歐飛克I，“用蔓越莓汁成份抑制牙菌斑細菌之種類間共聚集，”美國牙醫協會期刊(J. Am. Dent. Assoc.
) 1988年12月；129(12)：1719-23中。
含有0.3%蔓越莓萃出物NDM之漱口水配方具有抗共聚集效力及細菌生長抑制效力二者。於表3中所顯示之抗共聚集結果指出蔓越莓萃出物NDM有效地抑制細菌配對之共聚集。
抗共聚集分析之特定實驗方法係說明於韋斯EI，里夫-朵R，卡沙曼Y，歌德哈J，沙隆N，歐飛克I，“用蔓越莓汁成份抑制牙菌斑細菌之種類間共聚集，”美國牙醫協會期刊(J. Am. Dent. Assoc.
) 1988年12月；129(12)：1719-23中。
於表3中所顯示的結果指出於純溶液中之蔓越莓萃出物NDM為有效的細菌共聚集抑制劑。
0=無共聚集(完全抑制)；4=全部共聚集(無抑制作用)
So/Fn：口腔鏈球菌(Streptococcus oralis
)/有核梭桿菌(Fusobacterium nucleatum
)
作用/內氏放線菌(Actinomyces naeslundii
)/變異鏈球菌(S. mutan
)
細菌黏性放線菌係從生長於血液瓊脂板上之單一菌落增殖。將其無菌地轉移至含有30毫升無菌TSB培養基之離心管。然後將該離心管置於37.5℃之培育器中生長過夜。次日，將該細菌之溶液予以革蘭氏染色而純化且然後於UV分光計上以610毫微米稀釋至光密度為0.23。將9.6毫升體積之接種物加至Falcon管，用0.4毫升試驗之漱洗劑使產生最終稀釋為漱洗劑之1：25。然後將該管於37.5℃震盪水浴中培育。於特定之間隔時間，將1毫升從該管中移出且置於比色器中以便得到UV光譜。
此試管內分析顯示出蔓越莓萃出物NDM漱口水配劑當稀釋25倍時於黏放線菌之生長上具有抑制效應(表4及表5)。
本發明業已參考闡明實例說明於前，但應可瞭解本發明並非用所揭示之具體例來限制。精於此方面技藝之人士於閱讀本說明書時發生之改變及修正亦在本發明的範圍內，其係定義於所附加之申請專利範圍中。
Claims (21)
- 一種口腔保健組成物，其包含蔓越莓萃出物非透析性物質、氟化物離子來源及口腔上可接受的媒劑，其中該蔓越莓萃出物非透析性物質係以0.08-1.33毫克/毫升之濃度存在，且其中該組成物不包含去活化蔓越莓萃出物非透析性物質之組份，其係選自羥乙烯羥丙烯聚合體(poloxamers)或精油，其中該口腔上可接受的媒劑係為水、醇及一種或多種濕潤劑之組合，且其中該組成物不包含表面活性劑。
- 如申請專利範圍第1項之口腔保健組成物，其中該蔓越莓萃出物非透析性物質係以約0.3%重量/重量之濃度存在於組成物中。
- 如申請專利範圍第1項之口腔保健組成物，其中該氟化物離子來源為氟化鈉。
- 如申請專利範圍第1項之口腔保健組成物，其中該醇為乙醇，且該醇係以約6%重量/重量之濃度存在。
- 如申請專利範圍第4項之口腔保健組成物，其中該組成物為漱口水。
- 如申請專利範圍第1項之口腔保健組成物，其中該濕潤劑係選自於一種或多種由下列組成之群組：山梨糖醇、甘油，及其混合物。
- 如申請專利範圍第6項之口腔保健組成物，其中該濕潤劑係以約10%重量/重量之濃度存在。
- 如申請專利範圍第1項之口腔保健組成物，其中該組成物為漱口劑。
- 如申請專利範圍第1項之口腔保健組成物，其中組成物進一步包含一種或多種選自由下列組成之群組之試劑：抗牙菌斑劑、增白劑、防腐劑、甜化劑、洗淨劑、香味劑，及其混合物。
- 如申請專利範圍第1項之口腔保健組成物，其中，該組成物係為潔牙劑的型式選自由下列組成之群組：牙膏；深條紋牙膏；表面條紋牙膏；多層牙膏；凝膠圍繞的牙膏；粉末；小球體；漱口水；漱口劑；錠片；牙齒凝膠；牙周凝膠；適於塗搽牙齒表面之液體；口香糖；可溶、部份可溶或不可溶性薄膜或細條；扁片；擦拭紙或濕紙巾；植入物；泡沫體；片劑；牙線；含有經調配用於口腔施用於可攜式噴霧器中之液體；含有經調配用於口腔施用於可攜式小滴瓶中之液體；軟韌性錠劑("chewie(嚼易)")；及其組合。
- 一種口腔保健組成物用於製造供於口腔中抑制細菌共聚集的口腔保健產品之用途，其中該口腔保健組成物包含口腔上可接受的媒劑，其中含有濃度為0.08-1.33毫克/毫升之蔓越莓萃出物非透析性物質及氟化物離子來源，且其中該組成物不包含去活化蔓越莓萃出物非透析性物質的組份，其係選自羥乙烯羥丙烯聚合體(poloxamers)或精油，其中該口腔上可接受的媒劑係為 水、醇及一種或多種濕潤劑之組合，且其中該組成物不包含表面活性劑。
- 如申請專利範圍第11項之用途，其中該蔓越莓萃出物非透析性物質係以0.3%重量/重量之濃度存在於該組成物中。
- 如申請專利範圍第11項之用途，其中該氟化物離子來源為氟化鈉。
- 如申請專利範圍第11項之用途，其中該醇為乙醇。
- 如申請專利範圍第14項之用途，其中該醇係以約6%重量/重量之濃度存在。
- 如申請專利範圍第11項之用途，其中該濕潤劑係選自於一種或多種由下列組成之群組：山梨糖醇、甘油，及其混合物。
- 如申請專利範圍第16項之用途，其中該濕潤劑係以約10%重量/重量之濃度存在。
- 如申請專利範圍第11項之用途，其中該組成物為漱口劑。
- 如申請專利範圍第11項之用途，其中該組成物包括一種或多種選自抗牙菌斑劑、增白劑、防腐劑、甜化劑、洗淨劑及香味劑之其他試劑。
- 如申請專利範圍第11項之用途，其中該組成物係為潔牙劑的型式，其選自於由下列組成之群組：牙膏；深條紋牙膏；表面條紋牙膏；多層牙膏；凝膠圍繞的牙膏；粉末；小球體；漱口水；漱口劑；錠片；牙齒凝膠；牙 周凝膠；適於塗搽牙齒表面的液體；口香糖；可溶、部份可溶或不可溶性薄膜或細條；扁片；擦拭紙或濕紙巾；植入物；泡沫體；片劑；牙線；含有經調配用於口腔施用之液體於可攜式瓶中；含有經調配用於口腔施用之液體於可攜式小滴瓶中；軟韌性錠劑("嚼易")；及其組合。
- 一種口腔保健組成物，其包含口腔上可接受的媒劑及用於抑制細菌共聚集之試劑，其中該試劑實質上係由濃度為0.08-1.33毫克/毫升之蔓越莓萃出物非透析性物質所組成，且其中該組成物不包含去活化蔓越莓萃出物非透析性物質之組份，其係選自羥乙烯羥丙烯聚合體(poloxamers)或精油，其中該口腔上可接受的媒劑係為水、醇及一種或多種濕潤劑之組合，且其中該組成物不包含表面活性劑。
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|---|---|---|---|
| PCT/US2010/039725 WO2011162758A1 (en) | 2010-06-24 | 2010-06-24 | Oral care compositions and methods |
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| TW201212950A TW201212950A (en) | 2012-04-01 |
| TWI458500B true TWI458500B (zh) | 2014-11-01 |
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| JP (1) | JP2013529635A (zh) |
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| JP6016343B2 (ja) * | 2011-09-08 | 2016-10-26 | 株式会社ロッテ | 口腔用組成物 |
| IL246465A0 (en) | 2016-06-26 | 2016-11-30 | Ofek Itzhak | A preparation for dental care containing an extract of cranberry juice or an analogue with similar activity and a source of fluoride ion |
| CN115624506B (zh) * | 2021-07-16 | 2024-06-18 | 好维股份有限公司 | 一种包含菊粉的口腔护理组合物及其应用 |
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| US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
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| US5683678A (en) | 1995-03-09 | 1997-11-04 | The Procter & Gamble Company | Oral compositions |
| US6303125B1 (en) * | 1996-12-19 | 2001-10-16 | Ramot-University Authority For Applied Research And Industrial Development Ltd. | Anti-microbial-adhesion fraction derived from vaccinium |
| EP1379223A4 (en) * | 2001-03-27 | 2005-09-07 | C S Bioscience Inc | DENTAL PREPARATION |
| JP2006199661A (ja) * | 2005-01-24 | 2006-08-03 | Sunstar Inc | 共凝集阻害剤 |
| JP2009062339A (ja) * | 2007-09-07 | 2009-03-26 | Humic Kenkyusho:Kk | 口腔用組成物 |
| JP5552725B2 (ja) * | 2007-12-27 | 2014-07-16 | ライオン株式会社 | 口腔用組成物及び口腔バイオフィルム殺菌剤 |
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| US5840322A (en) * | 1996-12-19 | 1998-11-24 | Ramot-University Authority For Applied Research & Industrial Devel. Ltd. | Anti-oral-microbial adhesion fraction derived from vaccinium |
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| Title |
|---|
| Weiss EI,et al."A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite",FEMS Microbiology Letters 232(1),Mar 2004,89~92. * |
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| JP2013529635A (ja) | 2013-07-22 |
| BR112012029487A2 (pt) | 2017-01-10 |
| US20130089506A1 (en) | 2013-04-11 |
| TW201212950A (en) | 2012-04-01 |
| MX2012013582A (es) | 2013-01-24 |
| AU2010356104A1 (en) | 2012-12-13 |
| SG185625A1 (en) | 2012-12-28 |
| RU2013103097A (ru) | 2014-07-27 |
| PH12012502253A1 (en) | 2013-02-04 |
| CN102946854A (zh) | 2013-02-27 |
| RU2557981C2 (ru) | 2015-07-27 |
| WO2011162758A1 (en) | 2011-12-29 |
| AU2010356104B2 (en) | 2013-10-31 |
| EP2585035A1 (en) | 2013-05-01 |
| CA2799257A1 (en) | 2011-12-29 |
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