TWI377955B - Processes for preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid - Google Patents
Processes for preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacidInfo
- Publication number
- TWI377955B TWI377955B TW096130058A TW96130058A TWI377955B TW I377955 B TWI377955 B TW I377955B TW 096130058 A TW096130058 A TW 096130058A TW 96130058 A TW96130058 A TW 96130058A TW I377955 B TWI377955 B TW I377955B
- Authority
- TW
- Taiwan
- Prior art keywords
- processes
- preparation
- pharmaceutically acceptable
- acceptable salts
- pemetrexed diacid
- Prior art date
Links
- QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical class C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 title abstract 4
- 229960005079 pemetrexed Drugs 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- NYDXNILOWQXUOF-UHFFFAOYSA-L disodium;2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate Chemical class [Na+].[Na+].C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)NC(CCC([O-])=O)C([O-])=O)C=C1 NYDXNILOWQXUOF-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83730306P | 2006-08-14 | 2006-08-14 | |
| US83763706P | 2006-08-15 | 2006-08-15 | |
| US83955106P | 2006-08-22 | 2006-08-22 | |
| US84503106P | 2006-09-14 | 2006-09-14 | |
| US84729106P | 2006-09-25 | 2006-09-25 | |
| US85513906P | 2006-10-30 | 2006-10-30 | |
| US86055706P | 2006-11-21 | 2006-11-21 | |
| US86055406P | 2006-11-21 | 2006-11-21 | |
| US88017807P | 2007-01-11 | 2007-01-11 | |
| US88017907P | 2007-01-11 | 2007-01-11 | |
| US89992807P | 2007-02-06 | 2007-02-06 | |
| US93655307P | 2007-06-20 | 2007-06-20 | |
| US95832607P | 2007-07-02 | 2007-07-02 | |
| US95821307P | 2007-07-03 | 2007-07-03 | |
| US95841307P | 2007-07-05 | 2007-07-05 | |
| PCT/US2007/018098 WO2008021411A2 (en) | 2006-08-14 | 2007-08-14 | Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200824720A TW200824720A (en) | 2008-06-16 |
| TWI377955B true TWI377955B (en) | 2012-12-01 |
Family
ID=49584971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW096130058A TWI377955B (en) | 2006-08-14 | 2007-08-14 | Processes for preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8629152B2 (zh) |
| EP (1) | EP1943252B1 (zh) |
| JP (1) | JP2008543976A (zh) |
| KR (1) | KR101083230B1 (zh) |
| AT (1) | ATE492547T1 (zh) |
| DE (1) | DE602007011384D1 (zh) |
| ES (1) | ES2356792T3 (zh) |
| TW (1) | TWI377955B (zh) |
| WO (1) | WO2008021411A2 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0807939A2 (pt) | 2007-04-03 | 2014-07-01 | Reddys Lab Ltd Dr | Formas sólidas de pemetrexed |
| CN101684121B (zh) * | 2008-09-22 | 2013-04-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞二酸的新晶型及其制备方法 |
| CN102838602B (zh) * | 2011-06-21 | 2016-08-03 | 重庆医药工业研究院有限责任公司 | 培美曲塞氧化物及其制备方法 |
| WO2013179248A1 (en) | 2012-05-30 | 2013-12-05 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of pemetrexed |
| CA2888611A1 (en) * | 2012-10-17 | 2014-04-24 | Shilpa Medicare Limited | Process for preparing pemetrexed dipotassium and its hydrates |
| KR101260636B1 (ko) * | 2012-11-29 | 2013-05-13 | 씨제이제일제당 (주) | 안정화된 페메트렉시드 제제 |
| WO2014122460A2 (en) | 2013-02-06 | 2014-08-14 | Cipla House | Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes |
| EP2997031A1 (en) | 2013-05-17 | 2016-03-23 | Instytut Farmaceutyczny | Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid |
| EP3008064B1 (en) | 2013-06-14 | 2017-11-22 | Synthon B.V. | Stable pemetrexed arginine salt and compositions comprising it |
| KR101703980B1 (ko) | 2013-12-30 | 2017-02-08 | 주식회사 삼양바이오팜 | 항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법 |
| NZ630299A (en) * | 2014-06-30 | 2014-11-28 | Shilpa Medicare Ltd | Pemetrexed dipotassium formulations |
| JP2019505561A (ja) * | 2016-02-19 | 2019-02-28 | イーグル ファーマシューティカルズ， インコーポレイテッド | ペメトレキセド製剤 |
| US20170239250A1 (en) | 2016-02-19 | 2017-08-24 | Eagle Pharmaceuticals, Inc. | Pemetrexed formulations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| IL96531A (en) | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| CA2032695A1 (en) | 1989-12-20 | 1991-06-21 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
| US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| US6262262B1 (en) * | 1997-09-26 | 2001-07-17 | Eli Lilly And Company | Processes and intermediates useful to make antifolates |
| EP1212325A2 (en) | 1999-08-23 | 2002-06-12 | Eli Lilly And Company | A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor |
| HU229704B1 (en) | 2000-02-25 | 2014-05-28 | Lilly Co Eli | A novel crystalline form of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid and process for its preparation |
| KR20070107075A (ko) * | 2005-02-16 | 2007-11-06 | 쉐링 코포레이션 | Ｃｘｃｒ３ 길항제 활성을 갖는 신규의 헤테로사이클릭치환된 피리딘 또는 페닐 화합물 |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| BRPI0807939A2 (pt) | 2007-04-03 | 2014-07-01 | Reddys Lab Ltd Dr | Formas sólidas de pemetrexed |
-
2007
- 2007-08-14 US US11/893,234 patent/US8629152B2/en active Active
- 2007-08-14 DE DE602007011384T patent/DE602007011384D1/de active Active
- 2007-08-14 JP JP2008530049A patent/JP2008543976A/ja active Pending
- 2007-08-14 TW TW096130058A patent/TWI377955B/zh active
- 2007-08-14 AT AT07836879T patent/ATE492547T1/de not_active IP Right Cessation
- 2007-08-14 ES ES07836879T patent/ES2356792T3/es active Active
- 2007-08-14 KR KR1020087029220A patent/KR101083230B1/ko active Active
- 2007-08-14 EP EP07836879A patent/EP1943252B1/en active Active
- 2007-08-14 WO PCT/US2007/018098 patent/WO2008021411A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1943252B1 (en) | 2010-12-22 |
| KR101083230B1 (ko) | 2011-11-11 |
| WO2008021411A2 (en) | 2008-02-21 |
| ATE492547T1 (de) | 2011-01-15 |
| JP2008543976A (ja) | 2008-12-04 |
| EP1943252A2 (en) | 2008-07-16 |
| ES2356792T3 (es) | 2011-04-13 |
| TW200824720A (en) | 2008-06-16 |
| WO2008021411A3 (en) | 2008-04-10 |
| DE602007011384D1 (de) | 2011-02-03 |
| US20080139810A1 (en) | 2008-06-12 |
| US8629152B2 (en) | 2014-01-14 |
| KR20090035478A (ko) | 2009-04-09 |
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