TWI372761B - Method for purification of adefovir dipivoxil - Google Patents
Method for purification of adefovir dipivoxilInfo
- Publication number
- TWI372761B TWI372761B TW098130789A TW98130789A TWI372761B TW I372761 B TWI372761 B TW I372761B TW 098130789 A TW098130789 A TW 098130789A TW 98130789 A TW98130789 A TW 98130789A TW I372761 B TWI372761 B TW I372761B
- Authority
- TW
- Taiwan
- Prior art keywords
- purification
- adefovir dipivoxil
- dipivoxil
- adefovir
- Prior art date
Links
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 title 1
- 229960003205 adefovir dipivoxil Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20080089907 | 2008-09-11 | ||
| KR1020090001395A KR20100031045A (ko) | 2008-09-11 | 2009-01-08 | 아데포비어 디피복실의 정제방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201016713A TW201016713A (en) | 2010-05-01 |
| TWI372761B true TWI372761B (en) | 2012-09-21 |
Family
ID=42180843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098130789A TWI372761B (en) | 2008-09-11 | 2009-09-11 | Method for purification of adefovir dipivoxil |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110207928A1 (zh) |
| EP (1) | EP2327708A4 (zh) |
| JP (2) | JP5390617B2 (zh) |
| KR (2) | KR20100031045A (zh) |
| CN (1) | CN102143967B (zh) |
| TW (1) | TWI372761B (zh) |
| WO (1) | WO2010030132A2 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI609745B (zh) * | 2015-07-02 | 2018-01-01 | 嘉新精密有限公司 | 側向夾持的彈性定位塊結構 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20071594A1 (it) * | 2007-08-02 | 2009-02-03 | Solmag Spa | Forma cristallina monoidrata di adefovir dipivoxil |
| KR20100031045A (ko) * | 2008-09-11 | 2010-03-19 | 씨제이제일제당 (주) | 아데포비어 디피복실의 정제방법 |
| KR20100032803A (ko) * | 2008-09-18 | 2010-03-26 | 씨제이제일제당 (주) | 아데포비어디피복실의 개선된 제조방법 |
| KR101247653B1 (ko) * | 2010-11-08 | 2013-04-01 | (주) 성운파마코피아 | 아데포비어 디피복실 제조방법 |
| US8969588B2 (en) * | 2012-06-05 | 2015-03-03 | Gilead Pharmasset Llc | Solid forms of an antiviral compound |
| CN103880884A (zh) * | 2014-03-21 | 2014-06-25 | 浙江苏泊尔制药有限公司 | 一种高纯度富马酸泰诺福韦酯的制备方法 |
| CN105294762A (zh) * | 2015-11-13 | 2016-02-03 | 中国药科大学 | 阿德福韦酯杂质的制备方法 |
| CN106167503B (zh) * | 2016-07-07 | 2018-06-22 | 福建广生堂药业股份有限公司 | 一种阿德福韦酯羟甲基杂质的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0481214T3 (da) * | 1990-09-14 | 1999-02-22 | Acad Of Science Czech Republic | Prolægemidler af phosphonater |
| PT1256585E (pt) | 1997-07-25 | 2005-01-31 | Gilead Sciences Inc | Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina |
| ZA986614B (en) * | 1997-07-25 | 1999-01-27 | Gilead Sciences | Nucleotide analog composition |
| TWI230618B (en) * | 1998-12-15 | 2005-04-11 | Gilead Sciences Inc | Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same |
| CN1935818B (zh) * | 2006-09-22 | 2011-11-09 | 闫敬武 | 阿德福韦酯新晶态、晶态组合物、制备方法及应用 |
| KR20100031045A (ko) * | 2008-09-11 | 2010-03-19 | 씨제이제일제당 (주) | 아데포비어 디피복실의 정제방법 |
| JP2012502902A (ja) * | 2008-09-17 | 2012-02-02 | シージェイ チェルジェダン コーポレイション | アデホビルジピボキシルの安定化した固体分散体及びその製造方法 |
| KR20100032803A (ko) * | 2008-09-18 | 2010-03-26 | 씨제이제일제당 (주) | 아데포비어디피복실의 개선된 제조방법 |
-
2009
- 2009-01-08 KR KR1020090001395A patent/KR20100031045A/ko active Pending
- 2009-09-10 EP EP09813254A patent/EP2327708A4/en not_active Withdrawn
- 2009-09-10 JP JP2011526814A patent/JP5390617B2/ja not_active Expired - Fee Related
- 2009-09-10 US US13/063,449 patent/US20110207928A1/en not_active Abandoned
- 2009-09-10 WO PCT/KR2009/005150 patent/WO2010030132A2/ko not_active Ceased
- 2009-09-10 KR KR1020090085444A patent/KR100970434B1/ko active Active
- 2009-09-10 CN CN200980134900.2A patent/CN102143967B/zh not_active Expired - Fee Related
- 2009-09-11 TW TW098130789A patent/TWI372761B/zh not_active IP Right Cessation
-
2013
- 2013-10-09 JP JP2013212040A patent/JP2014114271A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI609745B (zh) * | 2015-07-02 | 2018-01-01 | 嘉新精密有限公司 | 側向夾持的彈性定位塊結構 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100970434B1 (ko) | 2010-07-15 |
| KR20100031085A (ko) | 2010-03-19 |
| CN102143967B (zh) | 2015-02-04 |
| JP5390617B2 (ja) | 2014-01-15 |
| JP2014114271A (ja) | 2014-06-26 |
| CN102143967A (zh) | 2011-08-03 |
| WO2010030132A9 (ko) | 2010-08-05 |
| WO2010030132A3 (ko) | 2010-06-10 |
| JP2012512137A (ja) | 2012-05-31 |
| TW201016713A (en) | 2010-05-01 |
| US20110207928A1 (en) | 2011-08-25 |
| EP2327708A4 (en) | 2011-11-30 |
| KR20100031045A (ko) | 2010-03-19 |
| EP2327708A2 (en) | 2011-06-01 |
| WO2010030132A2 (ko) | 2010-03-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |