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TWI371284B - - Google Patents

Info

Publication number
TWI371284B
TWI371284B TW095116441A TW95116441A TWI371284B TW I371284 B TWI371284 B TW I371284B TW 095116441 A TW095116441 A TW 095116441A TW 95116441 A TW95116441 A TW 95116441A TW I371284 B TWI371284 B TW I371284B
Authority
TW
Taiwan
Application number
TW095116441A
Other versions
TW200716151A (en
Inventor
Akira Masuda
Takeshi Onda
Hiroko Mashiba
Keiichirou Yamamoto
Kazutoshi Takashio
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of TW200716151A publication Critical patent/TW200716151A/zh
Application granted granted Critical
Publication of TWI371284B publication Critical patent/TWI371284B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0233—Polyamines derived from (poly)oxazolines, (poly)oxazines or having pendant acyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/3332—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing carboxamide group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/028—Polyamidoamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
TW095116441A 2005-05-11 2006-05-09 Polymeric derivative of cytidine metabolic antagonist TW200716151A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005138249 2005-05-11

Publications (2)

Publication Number Publication Date
TW200716151A TW200716151A (en) 2007-05-01
TWI371284B true TWI371284B (zh) 2012-09-01

Family

ID=37396423

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095116441A TW200716151A (en) 2005-05-11 2006-05-09 Polymeric derivative of cytidine metabolic antagonist

Country Status (13)

Country Link
US (1) US7700709B2 (zh)
EP (1) EP1881020B1 (zh)
JP (1) JP5000512B2 (zh)
KR (1) KR101312417B1 (zh)
CN (1) CN101218280B (zh)
AU (1) AU2006245107B2 (zh)
BR (1) BRPI0609095A2 (zh)
CA (1) CA2606939C (zh)
DE (1) DE602006016103D1 (zh)
ES (1) ES2350258T3 (zh)
RU (1) RU2404980C2 (zh)
TW (1) TW200716151A (zh)
WO (1) WO2006120914A1 (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1580216T3 (da) * 2002-10-31 2014-08-18 Nippon Kayaku Kk Derivater med høj molekylvægt af camptotheciner
PL1604687T3 (pl) * 2003-03-20 2011-04-29 Nippon Kayaku Kk Preparat micelarny zawierający słabo rozpuszczalny w wodzie lek przeciwnowotworowy oraz nowy kopolimer blokowy
WO2006033296A1 (ja) * 2004-09-22 2006-03-30 Nippon Kayaku Kabushiki Kaisha 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
WO2007111211A1 (ja) * 2006-03-28 2007-10-04 Nippon Kayaku Kabushiki Kaisha タキサン類の高分子結合体
RU2447095C2 (ru) * 2006-05-18 2012-04-10 Ниппон Каяку Кабусики Кайся Высокомолекулярный конъюгат подофиллотоксинов
US20100004403A1 (en) * 2006-07-19 2010-01-07 Masayuki Kitagawa High-Molecular Weight Conjugate of Combretastatins
ES2584840T3 (es) * 2006-10-03 2016-09-29 Nippon Kayaku Kabushiki Kaisha Compuesto de un derivado de resorcinol con un polímero
EP2080779B1 (en) * 2006-11-06 2016-05-18 Nippon Kayaku Kabushiki Kaisha Polymeric derivative of nucleic acid metabolic antagonist
WO2008055666A1 (en) * 2006-11-07 2008-05-15 Dsm Ip Assets B.V. Carbamate, thiocarbamate or carbamide comprising a biomolecular moiety
WO2008056654A1 (fr) * 2006-11-08 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
JP5349318B2 (ja) * 2007-09-28 2013-11-20 日本化薬株式会社 ステロイド類の高分子結合体
KR101589582B1 (ko) * 2008-03-18 2016-01-28 니폰 가야꾸 가부시끼가이샤 생리활성물질의 고분자량 결합체
EP2284209B1 (en) 2008-05-08 2016-08-31 Nippon Kayaku Kabushiki Kaisha Polymer conjugate of folic acid or folic acid derivative
WO2010131675A1 (ja) 2009-05-15 2010-11-18 日本化薬株式会社 水酸基を有する生理活性物質の高分子結合体
US8840875B2 (en) 2010-05-19 2014-09-23 Paolo Ferruti Anti-viral agents and compositions thereof
IT1401360B1 (it) * 2010-05-19 2013-07-18 Lembo Agenti anti-virali e relative composizioni
EP2641605B1 (en) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolism antagonist
WO2012098557A1 (en) * 2011-01-20 2012-07-26 Institute Of Life Sciences Pegylated gemcitabine derivative and process for preparing the same
EP2754682B1 (en) 2011-09-11 2017-06-07 Nippon Kayaku Kabushiki Kaisha Method for manufacturing block copolymer
US9855261B2 (en) 2012-11-08 2018-01-02 Nippon Kayaku Kabushiki Kaisha Polymeric compound having camptothecin compound and anti-cancer effect enhancer bound thereto, and use of same
JP2017160125A (ja) * 2014-08-04 2017-09-14 日本化薬株式会社 核酸代謝拮抗剤が結合したポリアミノ酸誘導体。
KR20170120568A (ko) * 2015-02-23 2017-10-31 니폰 가야꾸 가부시끼가이샤 생리활성물질결합 블록 공중합체
US20180334540A1 (en) * 2015-11-18 2018-11-22 Nippon Kayaku Kabushiki Kaisha Polymeric Derivative Of Macrolide Immunosuppressant
EP3400945A4 (en) 2016-01-08 2019-09-11 Nippon Kayaku Kabushiki Kaisha POLYMER DERIVATIVE OF MACROLIDE IMMUNOSUP PRESSIVA
CN106117561B (zh) * 2016-06-27 2020-03-13 中国科学院长春应用化学研究所 一种吉西他滨衍生物及其制备方法
JP6810239B2 (ja) * 2016-07-06 2021-01-06 サムヤン バイオファーマシューティカルズ コーポレイションＳａｍｙａｎｇ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ 難水溶性薬物を含む高分子ミセル製剤のインビトロ放出試験方法及び評価方法

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JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
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JPH0848766A (ja) * 1994-05-30 1996-02-20 Mitsui Toatsu Chem Inc 重合体及びその製造方法
JP2694923B2 (ja) 1995-08-21 1997-12-24 科学技術振興事業団 水溶性高分子化医薬製剤
JPH11279083A (ja) 1998-03-30 1999-10-12 Nippon Kayaku Co Ltd 可溶化剤
US6376470B1 (en) 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
JP2004532289A (ja) 2001-02-20 2004-10-21 エンゾン ファーマシューティカルズ，インコーポレーテッド 末端分枝高分子リンカーおよびそれを含む高分子複合体
KR20050115315A (ko) * 2003-03-26 2005-12-07 가부시키가이샤 엘티티 바이오파마 약물 전달 및 서방성 약물 방출을 표적으로 하는 정맥 내 나노입자
JP5632119B2 (ja) * 2003-09-17 2014-11-26 ウェルズ ファーゴ バンク ナショナル アソシエイション 多分岐ポリマーのプロドラッグ
WO2005030835A1 (ja) * 2003-09-25 2005-04-07 Terumo Kabushiki Kaisha ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体
ES2337904T3 (es) * 2003-12-10 2010-04-30 Toudai Tlo, Ltd. Complejo de coordinacion de diaminociclohexano platino (ii) como copolimero de bloques que contiene un segmento poli(acido carboxilico) y agente antitumoral que lo comprende.

Also Published As

Publication number Publication date
AU2006245107B2 (en) 2011-02-10
ES2350258T3 (es) 2011-01-20
JPWO2006120914A1 (ja) 2008-12-18
CA2606939A1 (en) 2006-11-16
RU2404980C2 (ru) 2010-11-27
US7700709B2 (en) 2010-04-20
EP1881020A1 (en) 2008-01-23
DE602006016103D1 (de) 2010-09-23
BRPI0609095A2 (pt) 2010-02-17
CN101218280A (zh) 2008-07-09
KR101312417B1 (ko) 2013-09-27
AU2006245107A1 (en) 2006-11-16
US20090012252A1 (en) 2009-01-08
EP1881020B1 (en) 2010-08-11
CN101218280B (zh) 2012-06-27
KR20080013883A (ko) 2008-02-13
TW200716151A (en) 2007-05-01
CA2606939C (en) 2013-09-03
JP5000512B2 (ja) 2012-08-15
RU2007145718A (ru) 2009-06-20
WO2006120914A1 (ja) 2006-11-16
EP1881020A4 (en) 2009-09-02

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