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TWI367857B - Fluidic nano/micro array chip and chipset thereof - Google Patents

Fluidic nano/micro array chip and chipset thereof

Info

Publication number
TWI367857B
TWI367857B TW096116367A TW96116367A TWI367857B TW I367857 B TWI367857 B TW I367857B TW 096116367 A TW096116367 A TW 096116367A TW 96116367 A TW96116367 A TW 96116367A TW I367857 B TWI367857 B TW I367857B
Authority
TW
Taiwan
Prior art keywords
chipset
array chip
micro array
fluidic
nano
Prior art date
Application number
TW096116367A
Other languages
Chinese (zh)
Other versions
TW200844037A (en
Inventor
Fan Gang Tseng
Cheng En Ho
Original Assignee
Nat Univ Tsing Hua
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Tsing Hua filed Critical Nat Univ Tsing Hua
Priority to TW096116367A priority Critical patent/TWI367857B/en
Priority to US12/110,551 priority patent/US20080280785A1/en
Publication of TW200844037A publication Critical patent/TW200844037A/en
Application granted granted Critical
Publication of TWI367857B publication Critical patent/TWI367857B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B01L3/0255—Drop counters; Drop formers using pins characterized by the form or material of the pin tip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0258—Drop counters; Drop formers using stamps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0036—Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00382—Stamping
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/021—Adjust spacings in an array of wells, pipettes or holders, format transfer between arrays of different size or geometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
TW096116367A 2007-05-09 2007-05-09 Fluidic nano/micro array chip and chipset thereof TWI367857B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
TW096116367A TWI367857B (en) 2007-05-09 2007-05-09 Fluidic nano/micro array chip and chipset thereof
US12/110,551 US20080280785A1 (en) 2007-05-09 2008-04-28 Fluidic nano/micro array chip and chipset thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW096116367A TWI367857B (en) 2007-05-09 2007-05-09 Fluidic nano/micro array chip and chipset thereof

Publications (2)

Publication Number Publication Date
TW200844037A TW200844037A (en) 2008-11-16
TWI367857B true TWI367857B (en) 2012-07-11

Family

ID=39970072

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096116367A TWI367857B (en) 2007-05-09 2007-05-09 Fluidic nano/micro array chip and chipset thereof

Country Status (2)

Country Link
US (1) US20080280785A1 (en)
TW (1) TWI367857B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9636653B2 (en) 2012-09-28 2017-05-02 Technische Universiteit Twente Stamp for making a microarray of biomolecules
EP2712672A1 (en) 2012-09-28 2014-04-02 Technische Universiteit Twente Stamp for making a microarray of biomolecules
TWI494565B (en) * 2013-07-09 2015-08-01 Nat Univ Tsing Hua Manufacturing method of biomedical molecular detection platform and detection platform made thereby
CA3161989A1 (en) 2014-07-23 2016-01-28 Inova Diagnostics, Inc. Compositions and methods for the diagnosis of rheumatoid arthritis
USD815752S1 (en) * 2014-11-28 2018-04-17 Randox Laboratories Ltd. Biochip well
USD771834S1 (en) * 2015-04-28 2016-11-15 University Of British Columbia Microfluidic cartridge
US11390836B2 (en) * 2016-11-17 2022-07-19 Cleveland State University Chip platforms for microarray 3D bioprinting
CN110947433A (en) * 2018-09-26 2020-04-03 首都师范大学 A method of making paper-based microfluidic chips
CN116948801A (en) * 2018-11-28 2023-10-27 深圳华大智造科技股份有限公司 Systems and methods for integrating biochips
WO2020124301A1 (en) * 2018-12-17 2020-06-25 深圳先进技术研究院 Device for generating droplet array, preparation method therefor and application thereof
CA3129624A1 (en) 2019-02-15 2020-08-20 Inova Diagnostics, Inc. Compositions and methods for diagnosing and assessing rheumatoid arthritis
US20220193678A1 (en) * 2019-04-08 2022-06-23 Technion Research And Development Foundation, Ltd. Multiplexed array of nanoliter droplet array device
PL4011494T3 (en) * 2019-12-14 2025-10-06 Shenzhen Institutes Of Advanced Technology Micro-nanofluidic chip, preparation method therefor and use thereof
CN113145183B (en) * 2020-01-22 2022-12-06 京东方科技集团股份有限公司 Biological chip and its making method
WO2021231879A1 (en) 2020-05-15 2021-11-18 Inova Diagnostics, Inc. Compositions and methods for diagnosing and assessing rheumatoid arthritis using protein-arginine deiminase 1 (pad1) autoantigens
CN115555234B (en) * 2022-10-10 2023-05-09 大连理工大学 Method for manufacturing polymer needle below 100nm based on near field electrospinning
US20250085281A1 (en) 2023-09-12 2025-03-13 Inova Diagnostics, Inc. Detecting antibodies using antigens

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US6051190A (en) * 1997-06-17 2000-04-18 Corning Incorporated Method and apparatus for transferring and dispensing small volumes of liquid and method for making the apparatus
US6461812B2 (en) * 1998-09-09 2002-10-08 Agilent Technologies, Inc. Method and multiple reservoir apparatus for fabrication of biomolecular arrays
US6296702B1 (en) * 1999-03-15 2001-10-02 Pe Corporation (Ny) Apparatus and method for spotting a substrate
US20020159918A1 (en) * 2000-06-25 2002-10-31 Fan-Gang Tseng Micro-fabricated stamp array for depositing biologic diagnostic testing samples on bio-bindable surface
US7025935B2 (en) * 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
US7407630B2 (en) * 2003-09-19 2008-08-05 Applera Corporation High density plate filler
CA2574839A1 (en) * 2004-08-04 2006-03-23 Irm, Llc Multi-well container processing systems, system components, and related methods

Also Published As

Publication number Publication date
TW200844037A (en) 2008-11-16
US20080280785A1 (en) 2008-11-13

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees