TWI238716B - Therapeutic combination and pharmaceutical composition comprising angiotensin converting enzyme inhibitor and aldosterone receptor antagonist for treating cardiovascular disorder - Google Patents

Therapeutic combination and pharmaceutical composition comprising angiotensin converting enzyme inhibitor and aldosterone receptor antagonist for treating cardiovascular disorder Download PDF

Info

Publication number: TWI238716B
Authority: TW; Taiwan
Prior art keywords: patent application; scope; item; combination; vasopressin
Prior art date: 1998-11-06

Application number

TW88119425A

Other languages

English (en)

Chinese (zh)

Inventor

Alfonso T Perez

Debra J Asner

Richard J Lachapelle

John C Alexander

Barbara Roniker

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-06

Filing date

1999-11-06

Publication date

2005-09-01

1999-11-06 Application filed by Searle & Co filed Critical Searle & Co

2005-09-01 Application granted granted Critical

2005-09-01 Publication of TWI238716B publication Critical patent/TWI238716B/zh

Links

239000005541 ACE inhibitor Substances 0.000 title claims abstract description 41
229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 title claims abstract description 34
229940044551 receptor antagonist Drugs 0.000 title claims abstract description 15
239000002464 receptor antagonist Substances 0.000 title claims abstract description 15
102000003979 Mineralocorticoid Receptors Human genes 0.000 title claims abstract description 13
108090000375 Mineralocorticoid Receptors Proteins 0.000 title claims abstract description 13
208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 9
230000001225 therapeutic effect Effects 0.000 title claims abstract description 5
101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 title claims 2
101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 title claims 2
239000008194 pharmaceutical composition Substances 0.000 title abstract description 7
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims abstract description 52
229960002256 spironolactone Drugs 0.000 claims abstract description 42
238000011282 treatment Methods 0.000 claims abstract description 30
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GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims abstract description 19
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RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 claims abstract description 14
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 claims abstract description 13
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PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims description 11
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GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 claims description 11
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Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

TW88119425A 1998-11-06 1999-11-06 Therapeutic combination and pharmaceutical composition comprising angiotensin converting enzyme inhibitor and aldosterone receptor antagonist for treating cardiovascular disorder TWI238716B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10739898P	1998-11-06	1998-11-06

Publications (1)

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TWI238716B true TWI238716B (en)	2005-09-01

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TW88119425A TWI238716B (en)	1998-11-06	1999-11-06	Therapeutic combination and pharmaceutical composition comprising angiotensin converting enzyme inhibitor and aldosterone receptor antagonist for treating cardiovascular disorder

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AR (1)	AR021106A1 (es)
TW (1)	TWI238716B (es)
ZA (1)	ZA200103632B (es)

1999
- 1999-11-05 AR ARP990105623 patent/AR021106A1/es unknown
- 1999-11-06 TW TW88119425A patent/TWI238716B/zh active
2001
- 2001-05-04 ZA ZA200103632A patent/ZA200103632B/en unknown

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AR021106A1 (es)	2002-06-12
ZA200103632B (en)	2002-05-06

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