TW358091B - Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas - Google Patents
Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureasInfo
- Publication number
- TW358091B TW358091B TW085108193A TW85108193A TW358091B TW 358091 B TW358091 B TW 358091B TW 085108193 A TW085108193 A TW 085108193A TW 85108193 A TW85108193 A TW 85108193A TW 358091 B TW358091 B TW 358091B
- Authority
- TW
- Taiwan
- Prior art keywords
- compound
- alkyl
- formula
- same
- substituted
- Prior art date
Links
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 235000013877 carbamide Nutrition 0.000 title 1
- -1 cyclic ureas Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
- 239000002168 alkylating agent Substances 0.000 abstract 2
- 229940100198 alkylating agent Drugs 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/481,683 US5532357A (en) | 1995-06-07 | 1995-06-07 | Method for preparing N-monosubstituted and N,N'-disubstituted unsymmetrical cyclic ureas |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW358091B true TW358091B (en) | 1999-05-11 |
Family
ID=23912954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085108193A TW358091B (en) | 1995-06-07 | 1996-07-06 | Method for preparing N-monosubstituted and N, N'-disubstituted unsymmetrical cyclic ureas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5532357A (zh) |
| EP (2) | EP1029859A1 (zh) |
| JP (1) | JPH11506779A (zh) |
| KR (1) | KR19990022467A (zh) |
| CN (1) | CN1192209A (zh) |
| AR (1) | AR002384A1 (zh) |
| AU (1) | AU704535B2 (zh) |
| BR (1) | BR9609493A (zh) |
| CA (1) | CA2223391A1 (zh) |
| CZ (1) | CZ381997A3 (zh) |
| EA (1) | EA000363B1 (zh) |
| EE (1) | EE9700330A (zh) |
| HR (1) | HRP960259A2 (zh) |
| HU (1) | HUP9900913A2 (zh) |
| IL (1) | IL122424A0 (zh) |
| LT (1) | LT4381B (zh) |
| LV (1) | LV12045B (zh) |
| MX (1) | MX9709652A (zh) |
| NO (1) | NO975679L (zh) |
| NZ (1) | NZ309648A (zh) |
| PL (1) | PL323993A1 (zh) |
| SI (1) | SI9620077A (zh) |
| SK (1) | SK164397A3 (zh) |
| TW (1) | TW358091B (zh) |
| WO (1) | WO1996040652A1 (zh) |
| ZA (1) | ZA964847B (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466797A (en) * | 1994-06-30 | 1995-11-14 | The Du Pont Merck Pharmaceutical Company | Intermediates for the preparation of cyclic urea |
| US6054597A (en) * | 1995-11-14 | 2000-04-25 | Dupont Pharmaceuticals | Processes and intermediates for the preparation of cyclic urea HIV protease inhibitors |
| US6218386B1 (en) | 1996-11-08 | 2001-04-17 | Dupont Pharmaceuticals | A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor |
| US5932570A (en) * | 1996-11-08 | 1999-08-03 | Dupont Pharmaceuticals Company | 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors |
| BR9712910A (pt) * | 1996-11-08 | 2000-03-21 | Du Pont Pharm Co | ra o tratamento de infecção por hiv |
| WO1998043969A1 (en) * | 1997-03-31 | 1998-10-08 | Dupont Pharmaceuticals Company | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| US6218534B1 (en) | 1997-10-06 | 2001-04-17 | Dupont Pharmaceuticals Company | Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate |
| AU4698399A (en) * | 1998-06-30 | 2000-01-17 | Du Pont Pharmaceuticals Company | 1,3-benzodiazepin-2-ones and 1,3-benzoxazepin-2-ones useful as hiv reverse transcriptase inhibitors |
| AU5588400A (en) | 1999-05-26 | 2000-12-18 | Du Pont Pharmaceuticals Company | 1,4-benzodiazepin-2-ones useful as hiv reverse transcriptase inhibitors |
| US6313110B1 (en) * | 1999-06-02 | 2001-11-06 | Dupont Pharmaceuticals Company | Substituted 2H-1,3-diazapin-2-one useful as an HIV protease inhibitor |
| FR2810039B1 (fr) * | 2000-06-13 | 2007-05-25 | Centre Nat Rech Scient | Composes urees cycliques et leur procede de preparation |
| US7015214B2 (en) * | 2001-03-28 | 2006-03-21 | Bristol-Myers Squibb Pharma Company | Cyanamide, alkoxyamino, and urea derivatives of 1,3-benzodiazepine as HIV reverse transcriptase inhibitors |
| US20080031951A1 (en) * | 2005-12-29 | 2008-02-07 | Gilles Guichard | Compositions and methods for the inhibition of phospholipase A2 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| DE69221309T2 (de) * | 1991-10-11 | 1997-12-11 | The Du Pont Merck Pharmaceutical Co., Wilmington, Del. | Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer |
| US5430043A (en) * | 1993-08-24 | 1995-07-04 | G. D. Searle & Co. | Platelet aggregation inhibitors |
| US5530124A (en) * | 1994-06-30 | 1996-06-25 | The Dupont Merck Pharmaceutical Company | Method for preparing cyclic ureas and their use for the synthesis of HIV protease inhibitors |
| US5466797A (en) * | 1994-06-30 | 1995-11-14 | The Du Pont Merck Pharmaceutical Company | Intermediates for the preparation of cyclic urea |
| US5532356A (en) * | 1995-06-06 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Method for preparing N,N'-disubstituted cyclic ureas |
| US7344671B2 (en) | 2003-11-26 | 2008-03-18 | Glopak Inc. | Optical sealing clamp and a method for sealing and cutting polymeric sheets with a laser |
| US7369013B2 (en) | 2005-04-06 | 2008-05-06 | Avago Technologies Wireless Ip Pte Ltd | Acoustic resonator performance enhancement using filled recessed region |
-
1995
- 1995-06-07 US US08/481,683 patent/US5532357A/en not_active Expired - Lifetime
-
1996
- 1996-06-06 CZ CZ973819A patent/CZ381997A3/cs unknown
- 1996-06-06 EP EP00109875A patent/EP1029859A1/en not_active Withdrawn
- 1996-06-06 SI SI9620077A patent/SI9620077A/sl unknown
- 1996-06-06 PL PL96323993A patent/PL323993A1/xx unknown
- 1996-06-06 MX MX9709652A patent/MX9709652A/es unknown
- 1996-06-06 HU HU9900913A patent/HUP9900913A2/hu unknown
- 1996-06-06 IL IL12242496A patent/IL122424A0/xx unknown
- 1996-06-06 HR HR481,683A patent/HRP960259A2/hr not_active Application Discontinuation
- 1996-06-06 NZ NZ309648A patent/NZ309648A/en unknown
- 1996-06-06 CA CA002223391A patent/CA2223391A1/en not_active Abandoned
- 1996-06-06 KR KR1019970708948A patent/KR19990022467A/ko not_active Withdrawn
- 1996-06-06 AU AU59868/96A patent/AU704535B2/en not_active Ceased
- 1996-06-06 EE EE9700330A patent/EE9700330A/xx unknown
- 1996-06-06 SK SK1643-97A patent/SK164397A3/sk unknown
- 1996-06-06 WO PCT/US1996/009021 patent/WO1996040652A1/en not_active Ceased
- 1996-06-06 EA EA199800034A patent/EA000363B1/ru not_active IP Right Cessation
- 1996-06-06 JP JP9501440A patent/JPH11506779A/ja active Pending
- 1996-06-06 EP EP96917212A patent/EP0837855A4/en not_active Withdrawn
- 1996-06-06 BR BR9609493A patent/BR9609493A/pt not_active Application Discontinuation
- 1996-06-06 CN CN96195932A patent/CN1192209A/zh active Pending
- 1996-06-07 AR AR10302696A patent/AR002384A1/es unknown
- 1996-06-07 ZA ZA9604847A patent/ZA964847B/xx unknown
- 1996-07-06 TW TW085108193A patent/TW358091B/zh active
-
1997
- 1997-12-03 LT LT97-188A patent/LT4381B/lt not_active IP Right Cessation
- 1997-12-05 NO NO975679A patent/NO975679L/no not_active Application Discontinuation
-
1998
- 1998-01-28 LV LVP-97-248A patent/LV12045B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9709652A (es) | 1998-03-29 |
| AU5986896A (en) | 1996-12-30 |
| LV12045A (lv) | 1998-05-20 |
| LT4381B (lt) | 1998-09-25 |
| US5532357A (en) | 1996-07-02 |
| EA000363B1 (ru) | 1999-06-24 |
| EE9700330A (et) | 1998-06-15 |
| SK164397A3 (en) | 2000-04-10 |
| EP0837855A1 (en) | 1998-04-29 |
| BR9609493A (pt) | 1999-03-02 |
| AR002384A1 (es) | 1998-03-11 |
| LV12045B (en) | 1998-09-20 |
| NZ309648A (en) | 1998-09-24 |
| NO975679D0 (no) | 1997-12-05 |
| EP0837855A4 (en) | 1998-09-02 |
| LT97188A (en) | 1998-04-27 |
| CZ381997A3 (cs) | 1999-01-13 |
| EA199800034A1 (ru) | 1998-08-27 |
| KR19990022467A (ko) | 1999-03-25 |
| CN1192209A (zh) | 1998-09-02 |
| CA2223391A1 (en) | 1996-12-19 |
| NO975679L (no) | 1998-02-02 |
| WO1996040652A1 (en) | 1996-12-19 |
| EP1029859A1 (en) | 2000-08-23 |
| HRP960259A2 (en) | 1997-10-31 |
| HUP9900913A2 (hu) | 1999-09-28 |
| AU704535B2 (en) | 1999-04-29 |
| JPH11506779A (ja) | 1999-06-15 |
| IL122424A0 (en) | 1998-06-15 |
| PL323993A1 (en) | 1998-04-27 |
| ZA964847B (en) | 1997-12-08 |
| SI9620077A (sl) | 1998-08-31 |
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