TW202008968A - Vertebral implant and method for manufacturing the same - Google Patents

Abstract

A vertebral implant includes a body, at least one fixing element and at least one screw. The body has at least one indentation and at least one through hole connected to each other. The fixing element is embedded in the indentation and has at least one first thread corresponding to the through hole. The screw is configured to pass through the through hole and thereby assembled with the body. The screw has at least one second thread corresponds and be fixed on the body by locking the first and second threads together.

Description

Spinal implants and methods of manufacture

The invention relates to a spinal implant and a method for manufacturing the same, and particularly relates to a spinal implant with a fixing element and a method for manufacturing the same.

The spine plays an important role in the human body and can support and protect important nerve tissue. Among them, the spine includes a vertebral body and an intervertebral disc. The intervertebral disc is located between the upper and lower vertebrae. It can absorb the pressure from the vertebrae and cushion the force and impact of the spine. However, when the intervertebral disc is compressed by long-term local stress, it is often easy to degenerate or protrude and compress the nerve, causing severe pain and not easy to relieve.

Recently, a common treatment method is spinal fusion surgery, or intervertebral fusion, which is a surgical operation to remove the disc that compresses the nerve or spinal cord, and the spinal implant is placed after the disc is removed. The formed cavity not only temporarily maintains the height between the two adjacent vertebral bodies, but also helps to achieve bone fusion in the future (for example, it can be combined with autologous bone) to restore the stability of the spine.

However, the amount of activity of the spine is quite large, especially the cervical spine. When the neck rotates or pitches, it causes relative displacement of the upper and lower vertebral bodies, which shakes the implant and causes slippage. Later, some medical material manufacturers developed implants with screws to directly lock the implants to the upper and lower vertebral bodies. However, the main material of the implant is the polymer material polyetherether ketone (PEEK). Although this material has both rigidity and elasticity, the rigidity is still lower than that of metal screws, so when the screws are shaken repeatedly , Will gradually withdraw backwards and lose the function of locking.

The modified spinal implant will assemble a harder metal material at the front end to replace the slightly lower rigid polyetheretherketone for screw locking. Because the two are the same metal (preferably the same metal material), the thread fits tightly, and the screw can be stably locked on the spinal implant. However, the way in which the metal block is assembled at the front of the implant to replace the original polyetheretherketone material also has its major disadvantages. First of all, because the metal material is too hard, it will cause local compression of the vertebral body on the contact surface and depression. Furthermore, because the metal material is not suitable for bone cells to grow on it, and the method of combining metal blocks will also affect the size of the bone graft space (that is, the space where bone repair materials such as autologous bone or artificial bone substitutes are accommodated), Seriously affect the speed and effect of bone fusion. In addition, the increase in metal materials will affect the surgeon's judgment on the shooting results of the mobile X-ray machine C-arm during the operation.

Therefore, there is still an urgent need to improve spinal implants, especially to prevent screw withdrawal while reducing the impact on the patient's bone fusion effect.

The invention relates to a spinal implant and a manufacturing method thereof. The implant of the present invention has the advantages of preventing screw withdrawal and reducing the impact on the patient's bone fusion.

According to a first aspect of the invention, a spinal implant is proposed. The spinal implant includes a body, at least one fixing element, and at least one screw. The body has at least one groove and at least one through hole communicating with each other. The fixing element is embedded in the groove. The fixing element has at least one first thread, and the first thread corresponds to the through hole. The screw passes through the through hole and is combined with the body, wherein the screw has at least one second thread corresponding to the first thread to lock on the first thread and be fixed on the body.

According to the second aspect of the present invention, a method for manufacturing a spinal implant is proposed. The method includes the following steps. First, one body of the spinal implant is provided. At least one groove and at least one through hole are formed on the body. Next, at least one fixing element is formed, and the fixing element has at least one first thread. The fixing element is embedded in the groove, and the first thread corresponds to the through hole. At least one screw is formed, the screw has at least one second thread corresponding to the first thread, the screw passes through the through hole and is combined with the body, and the second thread is locked to the first thread to be fixed on the body.

In order to have a better understanding of the above and other aspects of the present invention, the following examples are specifically described in conjunction with the accompanying drawings as follows:

FIG. 1A shows an exploded view of a spinal implant 100 according to an embodiment of the invention. FIG. 1B shows a top view of a spinal implant 100 according to an embodiment of the invention. FIG. 1C shows a cross-sectional view of the spinal implant 100 of FIG. 1B along the line A-A'.

Please refer to FIGS. 1A and 1B at the same time. The spinal implant 100 includes a body 110, a groove 112 and a through hole 114 communicating with each other, a fixing element 120 and a screw 140. The body 110 has an upper surface 110a and a lower surface 110b opposite to the upper surface 110a. The upper surface 110a and the lower surface 110b of the body 110 may have a tooth structure or a plurality of concave-convex structures, so as to increase the friction force between the contact surface of the spinal implant 100 and the vertebral body and reduce the relative displacement.

In this embodiment, the number of grooves 112 is two (grooves 112a, 112b), the number of through holes 114 is two (through holes 114a, 114b), and the number of fixing elements 120 is two (fixing elements 120a) , 120b), the number of screws 140 is two (screws 140a, 140b). The through hole 114 may extend from the front end AS to the rear end PS of the body 110, and the extending direction of the through hole 114a may be different from the extending direction of the through hole 114b. For example, the through hole 114a may extend from the front end AS toward the rear end PS toward the upper surface 110a. The through hole 114b may extend toward the rear end PS from the front end AS toward the lower surface 110b. The opening of the groove 112a is on the upper surface 110a, and can extend from the upper surface 110a of the body 110 to the lower surface 110b, but does not penetrate the body 110, that is, the groove 112a has no opening on the lower surface 110b; as for the opening of the groove 112b on the top The surface 110b may extend from the lower surface 110b to the upper surface 110a, but does not penetrate the body 110, that is, the groove 112a has no opening in the upper surface 110a. The groove 112a and the through hole 114a communicate with each other, and the groove 112b and the through hole 114b communicate with each other. In this embodiment, the through hole 114a penetrates the rear side of the groove 112a from the front side of the groove 112a in its extending direction, and the through hole 114b penetrates the rear side of the groove 112b from the front side of the groove 112b in its extending direction .

The fixing elements 120a and 120b are embedded in the grooves 112a and 112b, respectively. In this embodiment, the fixing element 120a is inserted through the opening of the upper surface 110a, and the fixing element 120b is inserted through the opening of the lower surface 110b. The fixing element 120a has a first thread 124a corresponding to the through hole 114a. In this embodiment, the corresponding correspondence is that, for example, after the fixing element 120a is inserted into the groove 112a, the first thread 124a can be wrapped around the through hole 114a penetrating the fixing element 120a. For example, the fixing elements 120a and 120b can have The openings 122a and 122b are through holes 114a and 114b penetrating the fixing elements 120a and 120b respectively, and the first screw threads 124a and 124b can be formed on the inner edges of the openings 122a and 122b, respectively.

The screw 140 a and the screw 140 b can be used to pass through the through holes 114 a and 114 b to be combined with the body 110. In this embodiment, the term “combination” means that two or more components are combined or connected together in a stable manner. The screws 140a, 140b may pass through the openings 122a, 122b on the fixing elements 120a, 120b, respectively. The screws 140a, 140b may have second threads 142a, 142b corresponding to the first threads 124a, 124b, respectively. The screws 140a and 140b are fixed to the body 110 in such a manner that the second threads 142a and 142b are locked to the first thread 124a in the groove 112a and the first thread 124b in the groove 112b. The second threads 142a, 142b and the screws 140a, 140b may have different threads for locking the vertebrae. For example, the second threads 142a, 142b may be provided at the upper end of the head SF or the extension SB of the screw 140 (and the thread locked to the vertebra Different aspects), or may extend continuously from the head SF to the extension SB (the same aspect as the thread locked to the vertebrae). During the operation, the spinal implant 100 can be placed between the two vertebral bodies, and then the screws 140a, 140b can be held by the instrument and enter through the through holes 114a, 114b. The first thread 124a, 124b and the second thread 142a and 142b are paired together, and the screws 140a and 140b are combined with the body 110, and also locked into the adjacent vertebrae upward and downward respectively. The shapes of the first thread 124 and the second thread 142 are not limited, as long as they can at least partially cooperate with each other. In this embodiment, the diameter of the screws 140a, 140b may be about 3 to 4 mm, and the length may be about 15 mm.

According to the above structural design, since a large angle is formed between the entry and exit directions of the fixing element 120 and the screw 140 (for the angle data, please refer to the following description), so the two cause a pinch to the other party's retreat or exit, and are more stable. The screw 140 stabilizes the spinal implant 100 and is less prone to wobbling or displacement.

The fixing element 120 may be a plate or a sheet. The thickness t of the fixing element 120 is between 0.5 mm and 10 mm, preferably between 0.8 mm and 3 mm, depending on whether the affected part is neck, chest, or lumbar And adjust. In this embodiment, the thickness t of the fixing element is about 1 to 2 mm, the length is about 5 to 5.5 mm, and the width is about 5 to 6 mm. However, the size of the fixing element can be adjusted due to the following factors: first, the size of the body 110 itself; second, the diameter of the screw 140. The fixing element 120 may have any shape such as a rectangle, a circle, and an irregular shape. In an embodiment, when the fixing element 120 is round or may be rotated in the groove 112, the fixing element 120 may have an engaging portion 126, and the groove 112 has a limiting portion 112p, the fixing element 120 Through the engaging portion 126 and the limiting portion 112 are engaged and fixed in the groove 112, the fixing element 120 can be prevented from rotating in place due to external force, which causes difficulty in locking the screws 140 a and 140 b. The shapes of the engaging portion 126 and the limiting portion 112p are not particularly limited as long as the two can be fixed to each other. However, the present invention is not limited to this. In some embodiments, the fixing element 120 does not have an engaging portion, and the groove 112 does not have a limiting portion.

The front end AS of the body 110 has a first width W ₁ in the extension direction along the X axis, and the rear end PS has a second width W ₂ in the extension direction along the X axis. The first width W _{1 is} greater than the second width W ₂ . The size and specification of the body 110 will vary depending on whether it is applied to the neck, chest, or lumbar spine. In this embodiment, the body 110 has a length of 12 mm, a width of about 15 to 16 mm, and a thickness of 5 mm. A bone grafting space 116 is also included. The shape of the bone grafting space 116 is trapezoidal, the length of the upper bottom is about 7 to 7.5 mm, the length of the lower bottom is about 9 mm, and the height (thickness) is 5 mm. The bone grafting space can accommodate or fill bone repair materials for assistance In this embodiment, since the space for bone growth is fixed in the recess 112, the amount of polyetheretherketone used in the body 110 can be maintained as much as possible to reduce the adverse conditions for bone growth. The groove 112 is formed between the front end AS of the body 110 and the bone graft space 116 of the body 110. Of course, in other embodiments, the groove 112 may be opened between the rear end PS or the side and the bone graft space 116.

Comparing the sizes of the body 110 and the fixing element 120 listed in the above embodiment, it can be seen that the size ratio of the fixing element 120 relative to the body 110 is much smaller than the conventional fixing means using metal blocks instead of and combined with the front end of the polyetheretherketone body , So you can reduce the impact on bone fusion and X-ray photography results.

The body 110 may be an integrally formed structure. The material of the body 110 may include, for example, a polymer material with high biocompatibility, and the polymer material with high biocompatibility is, for example, polyetheretherketone. The material of the fixing element 120 and the screw 140 may be metal, for example, titanium or stainless steel, or other medical grade metal materials.

In an embodiment, the fixing element 120 may additionally be provided with various forms of additional anti-retraction mechanisms, such as hole-shaped lock threads, hole-shaped anti-retraction pieces, etc., to further prevent the screw 140 from withdrawing.

In other embodiments, the number of the fixing elements 120 may be one or two or more, the number of screws 140 may be one or two or more, the number of the grooves 112 may be one or two or more, the through holes 114 The number can be one or two or more. The number of the openings 122 of the fixing element 120 corresponds to the number of screws 140 that need to be locked.

Referring to FIG. 1C, the depth of the groove 112 may be smaller than the thickness of the body 110. However, the disclosure is not limited to this. The depth of the groove 112 may also be equal to the thickness of the body 110, that is, a through hole may be formed, as long as the fixing element 120 can be provided to be embedded in the body 110. In this embodiment, the body 110 has six surfaces, and a side surface 110s corresponding to the front end AS is provided between the upper surface 110a and the lower surface 110b. In the extending direction of the Y axis, the fixing element 120 has a distance D ₁ from the side surface 110s. The pitch D1 is about 0 mm to 2 mm. After the fixing element 120 is placed in the groove 112, there is a difference height H ₁ between the upper surface 120s of the fixing element 120 and the upper surface 110a of the body 110 in the extending direction of the Z axis. The step height H ₁ is about 0.5 mm to 1.5 mm. The body 110 has a center line c in the Y-axis extension direction (for example, in the horizontal direction), and an angle θ between the center line c and the extension direction of the fixing element 120 The range of θ is between ten degrees and eighty degrees, preferably between twenty degrees and seventy degrees, and more preferably between thirty degrees and sixty degrees. There is an angle α between the center line c and the extending direction of the screw 140. In this embodiment, the angle α may range from ten degrees to eighty degrees, preferably from thirty degrees to sixty degrees. . By using the obliquely opened groove 112 and the obliquely provided screw 140, the fixing element 120 can be provided with a larger number of screw turns with a thinner thickness.

In one embodiment, the spinal implant 100 can be used for cervical spine implant treatment. Even though the cervical spine is more active than other spine parts, the locking of the spinal implant 100 through the first thread of the fixing element and the second thread of the screw can still stabilize the screw and avoid withdrawal, so that the spinal implant 100 can be more Firmly fixed between the cervical vertebrae. The present invention is not limited to this, spinal implants can also be applied to the treatment of vertebrae in other parts.

Figures 1D to 1G show enlarged views of the fixing element. FIG. 1D is a top view of the fixing element 120 according to an embodiment of the invention. FIG. 1E is a top view of a fixing element 220a according to another embodiment of the invention. FIG. 1F is a top view of a fixing element 220b according to another embodiment of the invention. FIG. 1G is a cross-sectional view of the fixing element 320 according to an embodiment of the invention.

Please refer to FIG. 1D. In the fixing element 120, the first thread 124 can completely surround the opening 122, that is, after the screw 140 is combined with the fixing element 120, the first thread 124 can completely surround the screw 140.

Referring to FIG. 1E, in the fixing element 220a, the first thread 224a may partially surround the opening 122a, that is, after the screw 140a is combined with the fixing element 220a, the first thread 224a may partially surround the screw 140a. For example, the first thread 224a may surround half of the inner edge of the opening 122a.

Referring to FIG. 1F, the fixing element 220b is similar to the fixing element 220a, except that the fixing element 220b does not form a closed opening, but forms an open opening 222b. The volume of the fixing element 220b is, for example, half that of the fixing element 220a. After the screw 140a is combined with the fixing element 220b, the first thread 224b may partially surround the screw 140a.

Please refer to FIG. 1G, which shows a cross-sectional view of the fixing element 320, which is formed by a line similar to the BB′ line in FIG. 1E, in the direction of the thickness t of the fixing element 320, along The inner edge portion has a plurality of first threads 324, such as first threads 324a and 324b.

FIG. 2 shows an exploded view of a spinal implant 400 according to yet another embodiment of the invention. The spinal implant 400 is similar to the spinal implant 100, except that the grooves 412a and 412b both extend from the same surface of the body 410.

Please refer to FIG. 2, the grooves 412 a and 412 b both extend from the upper surface 410 a of the body 410 to the lower surface 410 b. The upper surface 410a is opposite to the lower surface 410b. In an embodiment, the inclined directions of the grooves 412a and 412b may be different. For example, the groove 412a may be inclined toward the rear end PS, and the groove 412b may be inclined toward the front end AS. However, the present invention is not limited to this. The grooves 412a and 412b may not be inclined or inclined in the same direction. The grooves 412a and 412b communicate with the through holes 414a and 414b respectively. The fixing elements 420a and 420b are embedded in the grooves 412a and 412b respectively. The screws 140a and 140b pass through the through holes 414a and 414b and are combined with the body 410.

FIG. 3 shows an exploded view of a spinal implant 500 according to yet another embodiment of the invention. The spinal implant 500 is similar to the spinal implant 400 except that the number of grooves 512 and fixing elements 520 is one.

Referring to FIG. 3, the groove 512 extends from the upper surface 510a of the body 510 to the lower surface 510b. The upper surface 510a is opposite to the lower surface 510b. The groove 512 may not be inclined, or inclined toward the rear end PS or the front end AS. The groove 512 and the through holes 514a and 514b communicate with each other. The fixing element 520 has openings 522a and 522b. The inner edge of the fixing element 520 corresponding to the openings 522a and 522b may have at least one first thread. The fixing element 520 is embedded in the groove 512, and the screws 140a and 140b pass through the through holes 514a and 514b respectively and are combined with the body 510.

FIG. 4 shows an exploded view of a spinal implant 600 according to yet another embodiment of the invention. The spinal implant 600 is similar to the spinal implant 100 except that the position of the groove 612 is different.

Referring to FIG. 4, the body 610 has an upper surface 610a, a lower surface 610b opposite to the upper surface 610a, and side surfaces connected to the upper surface 610a and the lower surface 610b, wherein the side surfaces 610c, 610d extend from the front end AS to the rear The side surface of the end PS, the side surface 610c is opposite to the side surface 610d. The groove 612 may extend from the side surface 610c of the body 610 toward the side surface 610d. In an embodiment, another groove (not shown) may extend from the side surface 610d of the body 610 toward the side surface 610c. The groove 612 may not be inclined, or may be inclined toward the rear end PS or the front end AS. The groove 612 and the through hole 614a communicate with each other. The fixing element 620 has an opening 622. The inner edge of the fixing element 620 corresponding to the opening 622 may have at least one first thread. The fixing element 620 is embedded in the groove 612, and the screws 140 a and 140 b pass through the through holes 614 a and 614 b to be combined with the body 610.

5A to 5C are flowcharts illustrating a method of manufacturing and using a spinal implant 700 according to an embodiment of the invention.

Please refer to FIG. 5A, which shows the upper vertebra 10a and the lower vertebra 10b of the patient. The intervertebral disc between the vertebrae 10a and the vertebrae 10b is damaged, and treatment is required to fuse the vertebrae 10a and the vertebrae 10b.

Referring to FIG. 5B, a spinal implant 700 according to an embodiment of the present invention is placed between the vertebral bone 10a and the vertebral bone 10b. The method of manufacturing the spinal implant 700 is to first provide a body 710 of the spinal implant 700. After injection molding of a polymer material (such as PEEK), the molded product is processed on the surface to form a toothed groove (such as a plurality of concave-convex structures) to form the body 710. Next, grooves 712a, 712b and through holes 714a, 714b are formed in the body 710. The grooves 712a and 712b communicate with the through holes 714a and 714b, respectively. After that, the fixing elements 720a and 720b of the metal material are formed. The fixing elements 720a and 720b may have at least one first thread 724a and 724b, respectively. The fixing elements 720a, 720b are embedded in the grooves 712a, 712b, respectively, so that the first threads 724a, 724b correspond to the through holes 714a, 714b, respectively.

Referring to FIG. 5C, screws 740a and 740b are formed. The screws 740a and 740b may have at least one second thread (not shown). The screws 740a and 740b pass through the through holes 714a and 714b and the fixing elements 720a and 720b, respectively. The body 710 is combined and locked into the vertebrae 10a, 10b, respectively. Wherein, the screws 740a and 740b are respectively locked to the first threads 724a and 724b by second threads (not shown) and fixed to the body 710. In one embodiment, since the first thread 724a, 724b and the second thread (not shown) of the spinal implant 700 can cooperate with each other, the operator can use the instrument to engage the screws 740a, 740b with the fixing elements 720a, 720b, respectively. And continue to rotate toward the vertebral body, so that the screws 740a, 740b can be reliably locked into the vertebrae 10a, 10b, to complete the fixation of the spinal implant 700.

The spinal implant of the present invention cooperates with each other through the first thread of the fixing element and the second thread of the screw. Since both the fixing element and the screw are metal materials with similar hardness, the threads can be tightly matched, and the screw can be stably locked On spinal implants, even after a long period of relative displacement of the vertebral body, the screw can still be maintained in a proper locking position and not easy to slip off, allowing the spinal implant to be well fixed. Since the spinal implant of the present invention has a fixing element embedded in the groove, compared to a comparative example of a spinal implant in which a metal block is assembled at the front end of the implant to replace the original polyetheretherketone material , It is more convenient in the manufacturing process, the embedded fixing element is less likely to contact the vertebral body, which can avoid the depression between the contact surface of the vertebral body and the metal, and the body of the spinal implant of the present invention can be fully used It is formed of materials suitable for the growth of bone cells and does not require additional metal blocks, so it can expand the bone graft space and provide a better environment for bone fusion. Therefore, the spinal implant of the present invention not only has the function of preventing the screw from withdrawing, but also has the advantage of effectively reducing the impact on the patient's bone fusion.

In summary, although the present invention has been disclosed as above with examples, it is not intended to limit the present invention. Those with ordinary knowledge in the technical field to which the present invention belongs can make various modifications and retouching without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention shall be deemed as defined by the scope of the attached patent application.

10a, 10b ‧ spine 100, 400, 500, 600, 700 ‧ ‧ spine implants 110, 410, 510, 710 ‧ ‧‧ body 110a, 120s, 410a, 510a, 610a ‧ ‧ ‧ upper surface 110b, 410b, 510b, 610b ‧‧‧ lower surface 110s, 610c, 610d ‧‧‧ side surfaces 112, 112a, 112b, 412a, 412b, 512, 612, 712a, 712b ‧‧‧ groove 112p‧‧‧ limit part 114 , 114a, 114b, 414, 414a, 414b, 514a, 514b, 614a, 614b, 714a, 714b ‧‧‧ through hole 116 ‧‧‧ bone graft space 120, 120a, 120b, 220a, 220b, 320, 420a, 420b, 520, 620, 720a, 720b ‧‧‧ Fixing elements 122, 122a, 122b, 222a, 222b, 422a, 422b, 522a, 522b, 622 ‧‧‧ First thread 126‧‧‧ Engagement part 140, 140a, 140b, 740a, 740b ‧‧‧ Screw 142a, 142b ‧‧‧ Second thread A, A', B, B'‧‧‧ Point C‧‧‧Centerline D ₁ ‧‧‧Pitch H ₁ ‧‧‧ Height AS‧‧‧Front end PS‧‧‧ Rear end SF‧‧‧Head SB‧‧‧Extension t‧‧‧Thickness W ₁ , W ₂ ‧‧‧Width α, θ‧‧‧ included angle

FIG. 1A shows an exploded view of a spinal implant according to an embodiment of the invention. FIG. 1B shows a top view of a spinal implant according to an embodiment of the invention. FIG. 1C shows a cross-sectional view of the spinal implant 100 of FIG. 1B along the line A-A'. FIG. 1D is a top view of a fixing element according to an embodiment of the invention. FIG. 1E is a top view of a fixing element according to another embodiment of the invention. FIG. 1F is a top view of a fixing element according to another embodiment of the invention. FIG. 1G is a cross-sectional view of a fixing element according to an embodiment of the invention. Figure 2 shows an exploded view of a spinal implant according to yet another embodiment of the invention. Figure 3 shows an exploded view of a spinal implant according to yet another embodiment of the invention. Figure 4 shows an exploded view of a spinal implant according to yet another embodiment of the invention. 5A to 5C show a flowchart of a method of manufacturing and using a spinal implant according to an embodiment of the invention.

100‧‧‧Spine implant

110‧‧‧Body

110a‧‧‧upper surface

110b‧‧‧Lower surface

112, 112a, 112b ‧‧‧ groove

112p‧‧‧Limiting Department

114, 114a, 114b ‧‧‧ through hole

116‧‧‧Bone grafting space

120, 120a, 120b‧‧‧Fixed components

122, 122a, 122b ‧‧‧ opening

124a, 124b ‧‧‧ first thread

126‧‧‧Joint Department

140, 140a, 140b ‧‧‧ screws

142a, 142b ‧‧‧ second thread

AS‧‧‧Front end

PS‧‧‧Back

SF‧‧‧Head

SB‧‧‧Extension

t‧‧‧thickness

Claims (14)

A spinal implant includes a body with at least one groove and at least one through hole communicating with each other; 　　 at least one fixing element embedded in the groove, the fixing element has at least one first thread, the first thread Corresponding to the through hole; and at least one screw passing through the through hole to be combined with the body, wherein the screw has at least one second thread corresponding to the first thread to lock the first thread and be fixed to the body on. The spinal implant as described in item 1 of the patent application, wherein the thickness of the fixing element is between 0.5 mm and 10 mm. The spinal implant as described in item 1 of the patent application range, wherein the groove is formed between the front end of the body and a bone graft space of the body. The spinal implant as described in item 1 of the patent application scope, wherein the number of the fixing elements is greater than 1, the number of the grooves is greater than 1, and the fixing elements are respectively embedded in the grooves. The spinal implant as described in item 1 of the patent application scope, wherein the fixing element has a plurality of the first threads, the number of the screws is greater than 1, and the screws are respectively locked to the first of the fixing elements Thread. The spinal implant as described in item 1 of the patent application scope, wherein the fixing element has at least one opening, and the first thread is located at an inner edge of the opening. The spinal implant as described in item 1 of the patent scope, wherein the first thread completely surrounds the screw. The spinal implant as described in item 1 of the patent scope, wherein the first thread partially surrounds the screw. The spinal implant as described in item 1 of the patent scope, wherein the fixing element has an engaging portion, the groove has a limiting portion, and the fixing element is engaged with the limiting portion through the engaging portion Fixed in the groove. The spinal implant as described in item 1 of the patent scope, wherein the at least one fixing element includes a retreat prevention mechanism. The spinal implant as described in item 1 of the patent application scope, wherein the body includes: an upper surface; a lower surface, opposite to the upper surface; wherein the groove extends from the upper surface to the lower surface. The spinal implant as described in item 1 of the patent application scope, wherein the body includes: an upper surface; a lower surface, opposite to the upper surface; a first side surface, located between the upper surface and the lower surface; A second side surface is located between the upper surface and the lower surface, wherein the groove extends from the first side surface toward the second side surface. The spinal implant as described in item 1 of the patent application scope, wherein the body has a centerline in the horizontal direction, and the centerline has an angle between the extension direction of the fixing element, and the range of the angle is ten degrees To eighty degrees. A method for manufacturing a spinal implant, comprising: providing a body of the spinal implant; forming at least one groove and at least one through hole on the body; forming at least one fixing element, the at least one fixing element having at least one first Thread; embed the fixing element in the groove and make the first thread correspond to the through hole; form at least one screw with at least one second thread corresponding to the first thread, the screw passing through the through hole and It is combined with the body, and the second thread is locked on the first thread to be fixed on the body.

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