[go: up one dir, main page]

TW201827411A - Heterocycle derivatives as pesticides - Google Patents

Heterocycle derivatives as pesticides Download PDF

Info

Publication number
TW201827411A
TW201827411A TW106134315A TW106134315A TW201827411A TW 201827411 A TW201827411 A TW 201827411A TW 106134315 A TW106134315 A TW 106134315A TW 106134315 A TW106134315 A TW 106134315A TW 201827411 A TW201827411 A TW 201827411A
Authority
TW
Taiwan
Prior art keywords
alkyl
cycloalkyl
spp
group
alkoxy
Prior art date
Application number
TW106134315A
Other languages
Chinese (zh)
Inventor
大衛 威爾克
魯迪格 費雪
多明尼克 哈格
蘿菈 霍夫邁斯特
比西斯 妮娜 高施
馬可 莫索林
馬修 瓦洛特
漢斯 喬治 施瓦茨
克斯汀 伊格
奧瑞奇 喬根斯
安德列斯 圖伯格
Original Assignee
德商拜耳作物科學股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 德商拜耳作物科學股份有限公司 filed Critical 德商拜耳作物科學股份有限公司
Publication of TW201827411A publication Critical patent/TW201827411A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A01N43/52—1,3-Diazoles; Hydrogenated 1,3-diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to novel compounds of the formula (I) in which X, Q, R6, R7 and n have the definitions given above, to agrochemical formulations comprising the compounds of formula (I) and to the use thereof as acaricides and/or insecticides for control of animal pests.

Description

作為殺害蟲劑之雜環衍生物  Heterocyclic derivative as a pesticide  

本發明係有關一種新穎之式(I)雜環衍生物、含該式(I)化合物之農化調配物、其作為殺蜱蟎劑與/或殺昆蟲劑於控制動物害蟲(特定言之節肢動物，且尤指昆蟲與蜘蛛類)上之用途。 The present invention relates to a novel heterocyclic derivative of the formula (I), an agrochemical formulation containing the compound of the formula (I), which acts as an acaricide and/or an insecticide for controlling animal pests (specifically, an arthropod The use of animals, and especially insects and arachnids.

具有殺昆蟲性質之雜環衍生物已說明於文獻中，例如：WO 2010/125985、WO 2012/074135、WO 2012/086848、WO 2013/018928、WO 2013/191113、WO 2014/142292、WO 2014/148451、WO 2015/000715、WO 2016/124563、WO 2016/124557、WO 2015/121136、WO 2015/133603、WO 2015/198859、WO 2015/002211、WO 2015/071180、WO 2015/091945、WO 2016/005263、WO 2016/039441、WO 2016/039444、WO 2015/198817、WO 2016/041819、WO 2016/039441、WO 2016/026848、WO 2016/023954、WO 2016/020286、WO 2016/046071、WO 2016/058928、WO 2016/059145、WO 2016/071214、WO 2016/091731、WO 2016/096584、WO 2016/107742、WO 2016/107831、WO 2016/113155、WO 2016/116338、WO 2016/121997、WO 2016/125621、WO 2016/125622及WO 2016/129684。 Heterocyclic derivatives having insecticidal properties are described in the literature, for example: WO 2010/125985, WO 2012/074135, WO 2012/086848, WO 2013/018928, WO 2013/191113, WO 2014/142292, WO 2014/ 148451, WO 2015/000715, WO 2016/124563, WO 2016/124557, WO 2015/121136, WO 2015/133603, WO 2015/198859, WO 2015/002211, WO 2015/071180, WO 2015/091945, WO 2016/ 005263, WO 2016/039441, WO 2016/039444, WO 2015/198817, WO 2016/041819, WO 2016/039441, WO 2016/026848, WO 2016/023954, WO 2016/020286, WO 2016/046071, WO 2016/ 058928, WO 2016/059145, WO 2016/071214, WO 2016/091731, WO 2016/096584, WO 2016/107742, WO 2016/107831, WO 2016/113155, WO 2016/116338, WO 2016/121997, WO 2016/ 125621, WO 2016/125622 and WO 2016/129684.

EP 1767530說明結構類似式(I)化合物之苯并噁唑，其具有除草活性，但沒有顯著殺昆蟲作用。 EP 1767530 describes benzoxazoles which are structurally similar to the compounds of formula (I), which have herbicidal activity but have no significant insecticidal action.

然而，從上述文獻上已知之有些活性成份在應用上仍有缺點，其等僅具有狹隘的應用範圍或其可能沒有令人滿意的殺昆蟲或殺蜱蟎活性。 However, some of the active ingredients known from the above mentioned literature still have drawbacks in their application, such that they have only a narrow range of applications or they may not have satisfactory insecticidal or acaricidal activity.

然而，在應用上，從上述文獻上已知之有些活性成份仍有缺點，其等僅具有狹隘的應用範圍或其可能沒有令人滿意的殺昆蟲或殺蜱蟎活性。 However, in application, some of the active ingredients known from the above mentioned literature still have disadvantages, such that they have only a narrow range of applications or they may not have satisfactory insecticidal or acaricidal activity.

現已發現新穎之雜環衍生物，其等具有優於已知化合物之優點，其實例包括：更佳之生物或環境性質、更廣範圍之施用方法、更佳之殺昆蟲或殺蜱蟎作用、及與作物之良好相容性。該雜環衍生物可與其他用於改良效力(尤指對抗難以防治之昆蟲)之製劑組合使用本發明因此提供一種新穎式(I)化合物 Novel heterocyclic derivatives have been discovered which have advantages over known compounds, examples of which include: better biological or environmental properties, a wider range of application methods, better insecticidal or acaricidal effects, and Good compatibility with crops. The heterocyclic derivative can be used in combination with other formulations for improving efficacy, especially against insects that are difficult to control, thus providing a novel compound of formula (I)

其中(組態1)Q 為(C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、(C1-C6)鹵烷基-(C3-C8)環烷基、(C1-C6)烷氧基-(C3-C8)環烷基、(C1-C6)鹵烷氧基-(C3-C8)環烷基、鹵(C3-C8)環烷基、氰基(C3-C8)環烷基，或於各情況下為視需要經相同或相異基團取代一次或多次之芳基或雜芳基，其中(以雜芳基為例)可視需要存在至少一個羰基，且其中於各情況下可能之取代基如下：氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF5、三-(C1-C6)烷基矽基、(C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、(C1-C6)鹵烷基-(C3-C8)環烷基、鹵-(C3-C8)環烷基、氰基-(C3-C8)環烷基、(C1-C6)烷基、(C1-C6)鹵烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、羥基羰基-(C1-C6)-烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C2-C6)烯基、(C2-C6)鹵烯基、(C2-C6)氰基烯基、(C2-C6)炔基、(C2-C6)鹵炔基、(C2-C6)氰基炔基、(C1-C6)烷氧基、(C1-C6)鹵烷氧基、(C1-C6)氰基烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷氧基、(C1-C6)烷氧基-(C1-C6)烷氧基、(C1-C6)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C6)烷基硫基、(C1-C6)鹵烷基硫基、(C1-C6)烷氧基-(C1-C6)烷基硫基、(C1-C6)烷基硫 -(C1-C6)烷基、(C1-C6)烷基亞磺醯基、(C1-C6)鹵烷基亞磺醯基、(C1-C6)烷氧基-(C1-C6)烷基亞磺醯基、(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基、(C1-C6)鹵烷基磺醯基、(C1-C6)烷氧基-(C1-C6)烷基磺醯基、(C1-C6)烷基磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基氧基、(C1-C6)鹵烷基磺醯基氧基、(C1-C6)烷基羰基、(C1-C6)鹵烷基羰基、(C1-C6)烷基羰基氧基、(C1-C6)烷氧基羰基、(C1-C6)鹵烷氧基羰基、胺基羰基、(C1-C6)烷基胺基羰基、二-(C1-C6)烷基胺基羰基、(C1-C6)鹵烷基胺基羰基、(C2-C6)烯基胺基羰基、二-(C2-C6)-烯基胺基羰基、(C3-C8)環烷基胺基羰基、(C1-C6)烷基磺醯基胺基、(C1-C6)烷基胺基、二-(C1-C6)烷基胺基、胺基磺醯基、(C1-C6)烷基胺基磺醯基、二-(C1-C6)烷基胺基磺醯基、(C1-C6)烷基亞碸亞胺基、胺基硫基羰基、(C1-C6)烷基胺基硫基羰基、二-(C1-C6)烷基胺基硫基羰基、(C3-C8)環烷基胺基、NHCO-(C1-C6)烷基、NHCO-(C1-C6)鹵烷基、N(C1-C4)烷基-CO-(C1-C6)烷基、N(C1-C4)烷基-CO-(C1-C6)鹵烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C6)鹵烷基雜芳基或(C1-C6)鹵烷基側氧基雜芳基，R6 為(C1-C6)烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C1-C6)鹵烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4)鹵炔基或(C3-C8)環烷基，R7 為氫、(C1-C6)烷基、(C1-C6)鹵烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C1-C6)鹵烷氧基-(C1-C6)烷基、(C2-C6)烯基、(C2-C6)烯基氧-(C1-C6)烷基、(C2-C6)鹵烯基氧-(C1-C6)烷基、(C2-C6)鹵烯基、(C2-C6)氰基烯基、(C2-C6)炔基、(C2-C6)炔基氧-(C1-C6)烷基、(C2-C6)鹵炔基氧-(C1-C6)烷基、(C2-C6)鹵炔基、(C2-C6)氰基炔基、(C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、鹵(C3-C8)環烷基、(C1-C6)烷基硫-(C1-C6)烷基、(C1-C6)鹵烷基硫-(C1-C6)烷基、(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)鹵烷基亞磺醯基-(C1-C6)烷基、 (C1-C6)烷基磺醯基-(C1-C6)烷基、(C1-C6)鹵烷基磺醯基-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基硫-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基磺醯基-(C1-C6)烷基、(C1-C6)烷基羰基-(C1-C6)烷基、(C1-C6)鹵烷基羰基-(C1-C6)烷基、(C1-C6)烷氧基羰基-(C1-C6)烷基或(C1-C6)鹵烷氧基羰基-(C1-C6)烷基，X 為選自H1至H15群中之雜芳族9-員或12-員稠合雙環或三環系統 Wherein (Configuration 1) Q is (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl -(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )haloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkoxy-(C 3 -C 8 ) cycloalkyl, (C 1 -C 6 ) haloalkoxy-(C 3 -C 8 )cycloalkyl, halo(C 3 -C 8 )cycloalkyl, cyano (C 3 -C 8 ) a cycloalkyl group, or in each case an aryl or heteroaryl group which is optionally substituted one or more times by the same or a different group, wherein (in the case of a heteroaryl group) at least one carbonyl group may optionally be present, and wherein Possible substituents in each case are as follows: cyano, carboxy, halogen, nitro, ethyl hydrazine, hydroxy, amine, SCN, SF 5 , tris-(C 1 -C 6 )alkyl fluorenyl, (C 3- C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkane , (C 1 -C 6 )haloalkyl-(C 3 -C 8 )cycloalkyl, halo-(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, hydroxycarbonyl-(C 1 -C 6) - alkoxy, (C 1 -C 6) alkyl Carbonyl group - (C 1 -C 6) alkyl, (C 1 -C 6) alkoxy, - (C 1 -C 6) alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6 a haloalkenyl group, a (C 2 -C 6 )cyanoalkenyl group, a (C 2 -C 6 )alkynyl group, a (C 2 -C 6 )halynynyl group, a (C 2 -C 6 )cyanoalkynyl group, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyimino, (C 1 -C 6 ) haloalkoxyimino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, (C 1 -C 6 )alkoxy-(C 1 - C 6 )alkylthio, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 ) Haloalkylsulfinyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )haloalkylsulfonyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 ) alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyloxy, (C 1 - C 6 ) haloalkylsulfonyloxy, (C 1 -C 6 ) alkylcarbonyl, (C 1 -C 6 )haloalkylcarbonyl, (C 1 -C 6 )alkylcarbonyloxy, (C 1 -C 6 )alkoxycarbonyl, (C 1 -C 6 ) Haloalkoxycarbonyl, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, bis-(C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 )haloalkylamino Carbonyl, (C 2 -C 6 )alkenylaminocarbonyl, bis-(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 )cycloalkylaminocarbonyl, (C 1 -C 6 ) alkylsulfonylamino, (C 1 -C 6 )alkylamino, bis-(C 1 -C 6 )alkylamino, aminosulfonyl, (C 1 -C 6 ) alkane Aminosulfonyl, bis-(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkyl sulfoximine, aminothiocarbonyl, (C 1 -C 6 ) alkylaminothiocarbonyl, bis-(C 1 -C 6 )alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino, NHCO-(C 1 -C 6 ) alkane Base, NHCO-(C 1 -C 6 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )alkyl, N(C 1 -C 4 )alkyl-CO -(C 1 -C 6 )haloalkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, hetero Aryl, pendant oxyheteroaryl, haloaryl, halo-oxyheteroaryl, cyanide Heteroaryl, heteroaryl pendant cyano group, (C 1 -C 6) haloalkyl or heteroaryl (C 1 -C 6) haloalkyl side heteroaryl group, R 6 is (C 1 -C 6 )alkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl (C 1 -C 6 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 ) Haloalkynyl or (C 3 -C 8 )cycloalkyl, R 7 is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyano Alkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkenyloxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )haloenyloxy- (C 1 -C 6 )alkyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 ) Alkynyloxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )haloalkynyloxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )halynynyl, (C 2 -C 6 ) cyanoalkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 ) alkane Base-(C 3 -C 8 )cycloalkyl, halo(C 3 -C 8 )cycloalkyl, ( C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 ) alkane Sulfosyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl Sulfosyl-(C 1 -C 6 )alkyl, (C 1 -C 6 ) haloalkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-( C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy-(C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylcarbonyl- (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylcarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 An alkyl or (C 1 -C 6 ) haloalkoxycarbonyl-(C 1 -C 6 )alkyl group, X being a heteroaromatic 9-member or 12-membered fused bicyclic ring selected from the group H1 to H15 Three-ring system

R8、R9分別獨立為氫、氰基、鹵素、(C1-C4)烷基、(C1-C4)鹵烷基、(C2-C4) 烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C3-C6)環烷基、(C3-C6)環烷基-(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、(C1-C4)鹵烷基-(C3-C6)環烷基、氰基-(C3-C6)環烷基、鹵-(C3-C6)環烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)鹵烷氧基亞胺基(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺醯基氧基、(C1-C4)烷基羰基、(C1-C4)鹵烷基羰基、胺基羰基、(C1-C4)烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二-(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基或二-(C1-C4)烷基胺基磺醯基，R10 為氫、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)鹵烷氧基-(C1-C4)烷基、(C2-C4)烯基、(C2-C4)烯基氧-(C1-C4)烷基、(C2-C4)鹵烯基氧-(C1-C4)烷基、(C2-C4)鹵烯基、(C2-C4)氰基烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C3-C6)環烷基及n 為0、1或2，其中若X為H3時，n為1或2。 R 8 and R 9 are each independently hydrogen, cyano, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 - C 4 ) haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl- (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 ) Cycloalkyl, cyano-(C 3 -C 6 )cycloalkyl, halo-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halide Alkoxy, (C 1 -C 4 ) alkoxyimino, (C 1 -C 4 ) haloalkoxyimino (C 1 -C 4 )alkylthio, (C 1 -C 4 a haloalkylthio group, a (C 1 -C 4 )alkylsulfinyl group, a (C 1 -C 4 )haloalkylsulfinyl group, a (C 1 -C 4 )alkylsulfonyl group, C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 An alkylcarbonyl group, (C 1 -C 4 )haloalkylcarbonyl group, an aminocarbonyl group, a (C 1 -C 4 )alkylaminocarbonyl group, a di-(C 1 -C 4 )alkylaminocarbonyl group, C 1 -C 4) alkylsulfonyl amino group, (C 1 -C 4) alkylamino, di - (C 1 -C 4) alkylamino, amino sulfonic , (C 1 -C 4) alkylamino or di- sulfonic acyl - (C 1 -C 4) alkyl sulfonic acyl group, R 10 is hydrogen, (C 1 -C 4) -alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 ) Alkyl, (C 1 -C 4 ) haloalkoxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkenyloxy-(C 1 - C 4 )alkyl, (C 2 -C 4 )haloenyloxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )haloenyl, (C 2 -C 4 )cyanoalkenyl , (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3 -C 6 )cycloalkyl and n are 0, 1 or 2, wherein if X is H3, n is 1 or 2.

亦已發現式(I)化合物具有作為殺害蟲劑之極佳效力，較佳係作為殺昆蟲劑與/或殺蜱蟎劑，此外一般亦與植物(特定言之作物)具有極佳相容性。 It has also been found that the compounds of formula (I) have excellent efficacy as insecticidal agents, preferably as insecticides and/or acaricides, and generally also have excellent compatibility with plants, in particular crops. .

根據本發明化合物係如式(I)之一般定義。上文與下文所示化學式中基團之較佳取代基或範圍說明如下。 The compounds according to the invention are as defined generally in formula (I). Preferred substituents or ranges for the groups in the above formula and the formulas shown below are illustrated below.

組態2Configuration 2

Q 較佳為(C3-C6)環烷基、(C3-C6)環烷基-(C3-C6)環烷基、(C1-C6)烷基-(C3-C6)環烷基、(C1-C4)鹵烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基，或較佳於各情況下為視需要經相同或相異基團取代一次或多次之芳基或雜芳基，其中(以雜芳基為例)可視需要存在至少一個羰基，且其中於各情況下可能之取代基如下：氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF5、三-(C1-C6)烷基矽基、 (C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、(C1-C6)鹵烷基-(C3-C8)環烷基、鹵-(C3-C8)環烷基、氰基-(C3-C8)環烷基、(C1-C6)烷基、(C1-C6)鹵烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、羥基羰基-(C1-C6)-烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C2-C6)烯基、(C2-C6)鹵烯基、(C2-C6)氰基烯基、(C2-C6)炔基、(C2-C6)鹵炔基、(C2-C6)氰基炔基、(C1-C6)烷氧基、(C1-C6)鹵烷氧基、(C1-C6)氰基烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷氧基、(C1-C6)烷氧基-(C1-C6)烷氧基、(C1-C6)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C6)烷基硫基、(C1-C6)鹵烷基硫基、(C1-C6)烷氧基-(C1-C6)烷基硫基、(C1-C6)烷基硫-(C1-C6)烷基、(C1-C6)烷基亞磺醯基、(C1-C6)鹵烷基亞磺醯基、(C1-C6)烷氧基-(C1-C6)烷基亞磺醯基、(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基、(C1-C6)鹵烷基磺醯基、(C1-C6)烷氧基-(C1-C6)烷基磺醯基、(C1-C6)烷基磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基氧基、(C1-C6)鹵烷基磺醯基氧基、(C1-C6)烷基羰基、(C1-C6)鹵烷基羰基、(C1-C6)烷基羰基氧基、(C1-C6)烷氧基羰基、(C1-C6)鹵烷氧基羰基、胺基羰基、(C1-C6)烷基胺基羰基、(C1-C6)鹵烷基胺基羰基、(C2-C6)烯基胺基羰基、二-(C2-C6)-烯基胺基羰基、(C3-C8)環烷基胺基羰基、(C1-C6)烷基磺醯基胺基、(C1-C6)烷基胺基、二-(C1-C6)烷基胺基、胺基磺醯基、(C1-C6)烷基胺基磺醯基、二-(C1-C6)烷基胺基磺醯基、(C1-C6)烷基亞碸亞胺基、胺基硫基羰基、(C1-C6)烷基胺基硫基羰基、二-(C1-C6)烷基胺基硫基羰基、(C3-C8)環烷基胺基、NHCO-(C1-C4)烷基、N(C1-C4)烷基-CO-(C1-C4)烷基、NHCO-(C1-C4)鹵烷基、N(C1-C4)烷基-CO-(C1-C4)鹵烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C6)鹵烷基雜芳基或(C1-C6)鹵烷基側氧基雜芳基，R6 較佳為(C1-C4)烷基、(C1-C4)氰基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)鹵烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4) 鹵炔基或(C3-C6)環烷基，R7 較佳為氫、(C1-C6)烷基、(C1-C6)鹵烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C1-C6)鹵烷氧基-(C1-C6)烷基、(C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、鹵(C3-C8)環烷基、(C1-C6)烷基硫-(C1-C6)烷基、(C1-C6)鹵烷基硫-(C1-C6)烷基、(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)鹵烷基亞磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基-(C1-C6)烷基或(C1-C6)鹵烷基磺醯基-(C1-C6)烷基，X 較佳為選自H1、H2、H4、H5、H9、H11、H13、H14或H15群中之雜芳族9-員或12-員稠合雙環或三環系統，R8、R9 較佳分別獨立為氫、氰基、鹵素、(C1-C4)-烷基、(C1-C4)-鹵烷基、(C2-C4)-烯基、(C2-C4)-鹵烯基、(C2-C4)-炔基、(C2-C4)-鹵炔基、(C3-C6)-環烷基、(C3-C6)-環烷基-(C3-C6)-環烷基、(C1-C4)-烷基-(C3-C6)-環烷基、(C1-C4)鹵烷基-(C3-C6)環烷基、氰基-(C3-C6)環烷基、鹵-(C3-C6)環烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)鹵烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺醯基氧基、(C1-C4)烷基羰基、(C1-C4)鹵烷基羰基，R10 較佳為氫、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)鹵烷氧基-(C1-C4)烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C3-C6)環烷基，及n 較佳為0、1或2。 Q is preferably (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, or preferably in each case The aryl or heteroaryl group may be substituted one or more times by the same or a different group, wherein (in the case of a heteroaryl group), at least one carbonyl group may optionally be present, and wherein the substituents may be as follows in each case: Cyano, carboxyl, halogen, nitro, ethylidene, hydroxy, amine, SCN, SF 5 , tris-(C 1 -C 6 )alkyldecyl, (C 3 -C 8 )cycloalkyl, ( C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )halide Alkyl-(C 3 -C 8 )cycloalkyl, halo-(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, hydroxycarbonyl-(C 1 -C 6 )-alkoxy, (C 1 -C 6 ) alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 2 -C 6 ) Alkenyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 ) Cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )halynynyl, (C 2 -C 6 )cyanoalkynyl, (C 1 -C 6 )alkoxy (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkoxy, ( C 1 -C 6 ) alkoxy-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyimino, (C 1 -C 6 )halo alkoxyimino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )haloalkylsulfinyl, (C 1- C 6 ) alkoxy-(C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) haloalkylsulfonyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyloxy, (C 1 -C 6 )haloalkylsulfonyloxy a (C 1 -C 6 )alkylcarbonyl group, a (C 1 -C 6 )haloalkylcarbonyl group, a (C 1 -C 6 )alkylcarbonyloxy group, a (C 1 -C 6 )alkoxycarbonyl group, (C 1 -C 6) Alkoxycarbonyl, aminocarbonyl, (C 1 -C 6) alkylaminocarbonylamino, (C 1 -C 6) haloalkyl aminocarbonyl, (C 2 -C 6) alkenyl, aminocarbonyl, di -(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 )cycloalkylaminocarbonyl, (C 1 -C 6 )alkylsulfonylamino, (C 1 -C 6 An alkylamino group, a di-(C 1 -C 6 )alkylamino group, an aminosulfonyl group, a (C 1 -C 6 )alkylaminosulfonyl group, a di-(C 1 -C 6 ) Alkylaminosulfonyl, (C 1 -C 6 )alkylfluorenylene, aminothiocarbonyl, (C 1 -C 6 )alkylaminothiocarbonyl, di-(C 1 - C 6 ) alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-( C 1 -C 4 )alkyl, NHCO-(C 1 -C 4 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 )haloalkyl,NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant oxyheteroaryl, haloaryl, halo a pendant heteroaryl group, a cyanoheteroaryl group, a cyano sideoxyheteroaryl group, a (C 1 -C 6 )haloalkylheteroaryl group or a (C 1 -C 6 )haloalkyl sideoxy group an aryl group, R 6 preferably is (C 1 -C 4) alkyl, (C 1 -C 4) Alkyl, (C 1 -C 4) alkoxy, - (C 1 -C 4) alkyl, (C 1 -C 4) haloalkyl, (C 2 -C 4) alkenyl, (C 2 - C 4 ) haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynyl or (C 3 -C 6 )cycloalkyl, R 7 is preferably hydrogen, (C 1 - C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy -(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy-(C 1 -C 6 )alkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 a cycloalkyl-(C 3 -C 8 )cycloalkyl group, a (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl group, a halogen (C 3 -C 8 )cycloalkyl group, C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 ) alkane Isosulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl Sulfhydryl-(C 1 -C 6 )alkyl or (C 1 -C 6 ) haloalkylsulfonyl-(C 1 -C 6 )alkyl, X is preferably selected from H1, H2, H4, a heteroaromatic 9-member or 12-membered fused bicyclic or tricyclic ring system in the H5, H9, H11, H13, H14 or H15 group, preferably R 8 and R 9 are independently hydrogen, cyano, halogen, C 1 -C 4 )-alkane Group, (C 1 -C 4) - haloalkyl, (C 2 -C4) - alkenyl, (C 2 -C 4) - haloalkenyl, (C 2 -C 4) - alkynyl, (C 2 -C 4 )-haloalkynyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6 )-cycloalkyl-(C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )-alkyl-(C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, cyano-(C 3 -C 6 ) Cycloalkyl, halo-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy Imino, (C 1 -C 4 ) haloalkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 An alkylsulfinyl group, a (C 1 -C 4 )haloalkylsulfinyl group, a (C 1 -C 4 )alkylsulfonyl group, a (C 1 -C 4 )haloalkylsulfonyl group, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )halide Alkylcarbonyl, R 10 is preferably hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 Alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkoxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 ) haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 ) haloalkynyl, (C 3 -C 6 )cycloalkyl, and n is preferably 0, 1 or 2.

組態3-1Configuration 3-1

Q 更佳為(C3-C6)環烷基或於各情況下視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒、噻吩、呋喃、吡唑、噻唑、噁唑、咪唑或咪唑并吡啶，其中於各情況下可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、SF5-、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4) 烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)氰基烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C2-C4)氰基炔基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)氰基烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基硫-(C1-C4)烷基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺醯基氧基、(C1-C4)烷基羰基、(C1-C4)鹵烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、(C1-C4)鹵烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二-(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基、二-(C1-C4)烷基胺基磺醯基、NHCO-(C1-C4)烷基、N(C1-C4)烷基-CO-(C1-C4)烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C4)鹵烷基雜芳基或(C1-C4)鹵烷基側氧基雜芳基，R6 更佳為(C1-C4)烷基、(C1-C4)鹵烷基、(C2-C4)烯基、(C2-C4)鹵烯基或(C3-C4)環烷基，R7 更佳為氫、(C1-C6)烷基、(C1-C6)鹵烷基、(C3-C6)環烷基或鹵(C3-C6)環烷基，X 更佳為選自H1、H2、H9、H11、H13或H15群中之雜芳族9-員或12-員雙環或三環系統，R8 更佳為鹵素、(C1-C4)烷基、(C1-C4)鹵烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C3-C6)環烷基、(C1-C4)鹵烷基-(C3-C6)環烷基、氰基-(C3-C6)環烷基、鹵-(C3-C6)環烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)鹵烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺 醯基氧基、(C1-C4)烷基羰基或(C1-C4)鹵烷基羰基，R9 更佳為氫、氰基、鹵素、(C1-C4)烷基、(C1-C4)鹵烷基或(C3-C6)環烷基，R10 更佳為氫、(C1-C4)烷基、(C1-C4)鹵烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C1-C4)烷氧基-(C1-C4)烷基或(C3-C6)環烷基，及n 較佳為0、1或2。 More preferably, Q is a (C 3 -C 6 )cycloalkyl group or, in each case, one or more phenyl, pyridine, pyrimidine or anthracene which may be substituted one or more times by the same or a different group. , thiophene, furan, pyrazole, thiazole, oxazole, imidazole or imidazopyridine, wherein in each case possible substituents are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxyl, amine, SF 5 - (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy- (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )cyanoalkenyl, (C 2 -C 4 ) Alkynyl, (C 2 -C 4 )halynynyl, (C 2 -C 4 )cyanoalkynyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, ( C 1 -C 4 ) cyanoalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 6 ) haloalkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 )alkylthio-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl , (C 1 -C 4) halo alkylsulfonyl group, (C 1 -C 4) alkylsulfonyl oxy group (C 1 -C 4) haloalkyl sulfo acyl group, (C 1 -C 4) alkylcarbonyl, (C 1 -C 4) haloalkyl carbonyl, aminocarbonyl, amino thiocarbonyl group, ( C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )haloalkylaminocarbonyl, di-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkyl Sulfhydrylamino, (C 1 -C 4 )alkylamino, bis-(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonate Mercapto, di-(C 1 -C 4 )alkylaminosulfonyl, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 ) alkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant oxy Aryl, haloaryl, halooxyheteroaryl, cyanoheteroaryl, cyanoyloxyheteroaryl, (C 1 -C 4 )haloalkylheteroaryl or (C 1 -C 4 ) haloalkyl-tertiary heteroaryl, R 6 is more preferably (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl or (C 3 -C 4 )cycloalkyl, R 7 is more preferably hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3- C 6 )cycloalkyl or halo(C 3 -C 6 )cycloalkyl, X is more preferably selected from H1. a heteroaromatic 9-membered or 12-membered bicyclic or tricyclic ring system in the H2, H9, H11, H13 or H15 group, more preferably R 8 is halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 ) haloalkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3- C 6 )cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, cyano-(C 3 -C 6 )cycloalkyl, halo-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 4 ) a haloalkoxyimino group, a (C 1 -C 4 )alkylthio group, a (C 1 -C 4 )haloalkylthio group, a (C 1 -C 4 )alkylsulfinyl group, C 1 -C 4 ) haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkyl Sulfhydryloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 )alkylcarbonyl or (C 1 -C 4 )haloalkylcarbonyl, R 9 is more preferably Hydrogen, cyano, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl or (C 3 -C 6 )cycloalkyl, R 10 is more preferably hydrogen, (C 1 - C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 ) Alkynyl, (C 2 -C 4 )halynynyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl or (C 3 -C 6 )cycloalkyl, and n is preferred It is 0, 1, or 2.

組態3-2Configuration 3-2

Q 更佳於各情況下為視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒、噻吩、呋喃、吡唑、噻唑、噁唑或咪唑，其中於各情況下可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、SF5-、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)氰基烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C2-C4)氰基炔基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)氰基烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基硫-(C1-C4)烷基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺醯基氧基、(C1-C4)烷基羰基、(C1-C4)鹵烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、(C1-C4)鹵烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二-(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基、二-(C1-C4)烷基胺基磺醯基、NHCO-(C1-C4)烷基、N(C1-C4)烷基-CO-(C1-C4)烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C4)鹵烷基雜芳基或(C1-C4)鹵烷基側氧基雜芳基，及X、R6、R7、R8、R9、R10及n係依據組態3-1之定義。 Q is more preferably a phenyl, pyridine, pyrimidine, pyrene substituted one or more times by the same or a different group as needed in each case. , thiophene, furan, pyrazole, thiazole, oxazole or imidazole, wherein the possible substituents in each case are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxy, amine, SF 5 -, (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1 - C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )cyanoalkenyl, (C 2 -C 4 )alkynyl, ( C 2 -C 4 ) haloalkynyl, (C 2 -C 4 )cyanoalkynyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 ) cyanoalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 6 Haloloxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 )alkylsulfide-(C 1 -C 4 ) alkyl, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 )halane Sulfosyloxy, (C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )haloalkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylamine Carbonyl group, (C 1 -C 4 )haloalkylaminocarbonyl, bis-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino group, (C 1 -C 4 )alkylamino, bis-(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonyl, di-(C 1 - C 4 ) alkylaminosulfonyl, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 )alkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant oxyheteroaryl, haloaryl, halo a pendant heteroaryl group, a cyanoheteroaryl group, a cyano sideoxyheteroaryl group, a (C 1 -C 4 )haloalkylheteroaryl group or a (C 1 -C 4 )haloalkyl sideoxy group The aryl group, and X, R 6 , R 7 , R 8 , R 9 , R 10 and n are as defined in Configuration 3-1.

組態4-1Configuration 4-1

Q 甚至更佳為環丙基或於各情況下視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒、噻吩、噻唑、噁唑、咪唑或咪唑并[1,2-a]吡啶，其中於各情況下可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基、二(C1-C4)烷基胺基磺醯基、吡唑基或經鹵素取代之吡唑基，R6 甚至更佳為甲基、乙基、正丙基、異丙基、環丙基、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙基或五氟乙基，R7 甚至更佳為氫、甲基、乙基、正丙基、異丙基、環丙基、正丁基、異丁基、第三丁基、環丁基、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙基或五氟乙基，X 甚至更佳為H1、H2、H9、H11、H13或H15，R8 甚至更佳為氟、氯、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙基、五氟乙基、三氟甲氧基、二氟氯甲氧基、二氯氟甲氧基、三氟甲基硫基、三氟甲基磺醯基或三氟甲基亞磺醯基，R9 甚至更佳為氫，R10 甚至更佳為甲基、乙基、正丙基、異丙基、正丁基、異丁基、第三丁基、甲氧基甲基或甲氧基乙基，及n 甚至更佳為0、1或2。 Q is even more preferably a cyclopropyl group or, in each case, one or more phenyl, pyridine, pyrimidine, pyrene substituted by the same or different groups as needed. , thiophene, thiazole, oxazole, imidazole or imidazo[1,2-a]pyridine, wherein in each case possible substituents are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxy, amine, ( C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) Alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1- C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 ) alkane Oxyl, (C 1 -C 4 ) alkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 ) alkane (i-sulfonyl), (C 1 -C 4 ) haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, bis-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino, (C 1 -C 4 )alkylamino, bis(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 ) sulfo acyl alkylamino, di (C 1 -C 4) alkylamine Sulfo acyl, substituted pyrazolyl group or the halogen-pyrazolyl, R 6 and even more preferably methyl, ethyl, n-propyl, isopropyl, cyclopropyl, fluoromethyl, difluoromethyl, tris Fluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl or pentafluoroethyl, R 7 even more preferably hydrogen, methyl, ethyl, n-propyl, isopropyl, Cyclopropyl, n-butyl, isobutyl, tert-butyl, cyclobutyl, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, tetra Fluoroethyl or pentafluoroethyl, X is even more preferably H1, H2, H9, H11, H13 or H15, and R 8 is even more preferably fluorine, chlorine, fluoromethyl, difluoromethyl, trifluoromethyl, Fluoroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl, pentafluoroethyl, trifluoromethoxy, difluorochloromethoxy, dichlorofluoromethoxy, trifluoromethylthio , trifluoromethylsulfonyl or trifluoromethylsulfinyl, R 9 is even more preferably hydrogen, and R 10 is even more preferably methyl, ethyl, n-propyl, isopropyl, n-butyl, Isobutyl, tert-butyl, methoxymethyl or methoxyethyl, and n even more preferably 0, 1 or 2 .

組態4-2Configuration 4-2

Q 甚至更佳於各情況下為視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒、噻吩、噻唑、噁唑或咪唑，其中於各情況下可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基及二(C1-C4)烷基胺基磺醯基，及X、R6、R7、R8、R9、R10及n係依據組態4-1之定義。 Q is even more preferred in each case by substituting the same or a different group for one or more phenyl, pyridine, pyrimidine, pyrene , thiophene, thiazole, oxazole or imidazole, wherein in each case possible substituents are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxy, amine, (C 3 -C 6 )cycloalkyl, ( C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )halide Alkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 ) alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkoxy, (C 1 -C 4 ) alkane Oxyimido group, (C 1 -C 4 )alkylthio group, (C 1 -C 4 )haloalkylthio group, (C 1 -C 4 )alkylsulfinyl group, (C 1 -C 4 ) haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylcarbonyl, amine Carbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, bis-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino (C 1 -C 4 )alkylamino, bis(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonyl and di(C) 1 -C 4 )alkylaminosulfonyl, and X, R 6 , R 7 , R 8 , R 9 , R 10 and n are defined according to configuration 4-1.

組態5-1Configuration 5-1

Q 特定言之係環丙基或未經取代或經相同或相異之單-或二-氯-、-三氟甲基-或-4-氯吡唑-取代之苯基、吡啶、噻唑或咪唑并[1,2-a]吡啶，R6 特定言之係甲基或乙基，R7 特定言之係氫，X 特定言之係H1或H2，R8 特定言之係三氟甲基，R9 特定言之係氫，R10 特定言之係甲基，及n 特定言之係0、1或2。 Q, in particular, cyclopropyl or unsubstituted or substituted by the same or different mono- or di-chloro-, -trifluoromethyl- or 4-chloropyrazole-substituted phenyl, pyridine, thiazole or Imidazo[1,2-a]pyridine, R 6 is specifically methyl or ethyl, R 7 is specifically hydrogen, X is specifically H1 or H2, and R 8 is specifically trifluoromethyl. R 9 is specifically hydrogen, R 10 is a specific methyl group, and n is specifically 0, 1 or 2.

組態5-2Configuration 5-2

Q 特定言之係未經取代或經相同或相異之單-或二-氯-取代之苯基或吡啶，及X、R6、R7、R8、R9、R10及n係依據組態5-1之定義。 Q is specifically unsubstituted or substituted by the same or different mono- or di-chloro-substituted phenyl or pyridine, and X, R 6 , R 7 , R 8 , R 9 , R 10 and n are based on The definition of configuration 5-1.

下文中組態(x)等同組態(x-1)或(x-2)，其中x=1、2、3、4或5。 In the following configuration (x) is equivalent to configuration (x-1) or (x-2), where x=1, 2, 3, 4 or 5.

較佳實施例中，本發明係有關一種式(I)化合物其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，及Q具有組態(1)中說明之定義。 In a preferred embodiment, the invention relates to a compound of formula (I) wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or the definitions specified in configuration (4) or configuration (5), and Q has the definitions specified in configuration (1).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(3)或組態(4)或組態(5)中說明之定義，及Q具有組態(2)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (3) or Configuration (4) or Configuration (5), and Q has the definitions specified in Configuration (2).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(4)或組態(5)中說明之定義，及Q具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (4) or Configuration (5), and Q has the definitions specified in Configuration (3).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(5)中說明之定義，及Q具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (3) or Configuration (5), and Q has the definitions specified in Configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)中說明之定義，及Q具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (3) or Configuration (4), and Q has the definitions specified in Configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，及X具有組態(1)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (2) Or the definitions described in configuration (3) or configuration (4) or configuration (5), and X has the definitions specified in configuration (1).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(3)或組態(4)或組態(5)中說明之定義，及X具有組態(2)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (3) or Configuration (4) or Configuration (5), and X has the definitions specified in Configuration (2).

另一項較佳實施例中，本發明係有關一種式(I)化合物 其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(4)或組態(5)中說明之定義，及X具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (4) or Configuration (5), and X has the definitions specified in Configuration (3).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(5)中說明之定義，及X具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (3) or Configuration (5), and X has the definitions specified in Configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)中說明之定義，及X具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or the definitions described in Configuration (2) or Configuration (3) or Configuration (4), and X has the definitions specified in Configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，及X為H1、H2、H15或H13。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) Or configure (2) or configure (3) or configure (4) or configure (5) to define the definition, and X is H1, H2, H15 or H13.

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(1)中說明之定義，及R8、R9、R10具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (1), and R 8 , R 9 , R 10 have the definitions specified in configuration (3).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(1)中說明之定義，R8、R9、R10具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (1), and R 8 , R 9 , R 10 have the definitions specified in configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(1)中說明之定義，R8、R9、R10具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (1), and R 8 , R 9 , R 10 have the definitions specified in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(2)中說明之定義，R8、R9、R10具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (2), and R 8 , R 9 , R 10 have the definitions specified in configuration (3).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(2)中說明之定義，及R8、R9、R10具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (2), and R 8 , R 9 , R 10 have the definitions specified in configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，x具有(2)中說明之定義，及R8、R9、R10具有組態(5).中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), x has the definition described in (2), and R 8 , R 9 , R 10 have the definitions specified in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(3)中說明之定義，及R8、R9、R10具有組態(2)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (3), and R 8 , R 9 , R 10 have the definitions specified in configuration (2).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(3)中說明之定義，及R8、R9、R10具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (3), and R 8 , R 9 , R 10 have the definitions specified in configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(3)中說明之定義，及R8、R9、R10具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (3), and R 8 , R 9 , R 10 have the definitions specified in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(4)說明之定義，及R8、R9、R10具有組態(2)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition of configuration (4), and R 8 , R 9 , R 10 have the definitions specified in configuration (2).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(4)中說明之定義，及R8、R9、R10具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (4), and R 8 , R 9 , R 10 have the definitions specified in configuration (3).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X具有組態(4)中說明之定義，及R8、R9、R10具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X has the definition described in configuration (4), and R 8 , R 9 , R 10 have the definitions specified in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中之定義，X為H1、H2、H15或H13，及R8、R9、R10具有組態(2)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition in configuration (5), X is H1, H2, H15 or H13, and R 8 , R 9 , R 10 have the definitions specified in configuration (2).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X為H1、H2、H15或H13及R8、R9、R10具有組態(3)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the configuration (5) defined in the description, X is H1, H2, H15 or H13 and R 8, R 9, R 10 having the configuration definition (3) in the illustration.

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X為H1、H2、H15或H13，及R8、R9、R10具有組態(4)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X is H1, H2, H15 or H13, and R 8 , R 9 , R 10 have the definitions specified in configuration (4).

另一項較佳實施例中，本發明係有關一種式(I)化合物其中Q、R6、R7及n具有如上述定義，尤指組態(2)或組態(3)或組態(4)或組態(5)中說明之定義，X為H1、H2、H15或H13，及R8、R9、R10具有組態(5)中說明之定義。 In another preferred embodiment, the invention relates to a compound of formula (I) wherein Q, R 6 , R 7 and n have the definitions as defined above, in particular configuration (2) or configuration (3) or configuration (4) or the definition described in configuration (5), X is H1, H2, H15 or H13, and R 8 , R 9 , R 10 have the definitions specified in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I-A)化合物 In another preferred embodiment, the invention relates to a compound of formula (IA)

其中(組態A1)X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為氮、=N+(O-)-或=C(R1)-，A2 為氮、=N+(O-)-或=C(R2)-，A3 為氮、=N+(O-)-或=C(R3)-，A4 為氮、=N+(O-)-或=C(R4)-，A5 為氮、=N+(O-)-或=C(R5)-，其中A1、A2、A3、A4及A5之群中不超過兩個基為氮，及A1、A2、A3、A4及A5之群中不超過一個基為=N+(O-)，及R1、R2、R3、R4及R5分別獨立為氫、氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF5、三-(C1-C6)烷基矽基、(C3-C8)環烷基、(C3-C8)環烷基-(C3-C8)環烷基、(C1-C6)烷基-(C3-C8)環烷基、(C1-C6)鹵烷基-(C3-C8)環烷基、鹵-(C3-C8)環烷基、氰基-(C3-C8)環烷基、(C1-C6)烷基、(C1-C6)鹵烷基、(C1-C6)氰基烷基、(C1-C6)羥基烷基、羥基羰基-(C1-C6)-烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷基、(C1-C6)烷氧基-(C1-C6)烷基、(C2-C6)烯基、(C2-C6)鹵烯基、(C2-C6)氰基烯基、(C2-C6)炔基、(C2-C6)鹵炔基、(C2-C6)氰基炔基、(C1-C6)烷氧基、(C1-C6)鹵烷氧基、(C1-C6)氰基烷氧基、(C1-C6)烷氧基羰基-(C1-C6)烷氧基、(C1-C6)烷氧基-(C1-C6)烷氧基、(C1-C6)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C6)烷基硫基、(C1-C6) 鹵烷基硫基、(C1-C6)烷氧基-(C1-C6)烷基硫基、(C1-C6)烷基硫-(C1-C6)烷基、(C1-C6)烷基亞磺醯基、(C1-C6)鹵烷基亞磺醯基、(C1-C6)烷氧基-(C1-C6)烷基亞磺醯基、(C1-C6)烷基亞磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基、(C1-C6)鹵烷基磺醯基、(C1-C6)烷氧基-(C1-C6)烷基磺醯基、(C1-C6)烷基磺醯基-(C1-C6)烷基、(C1-C6)烷基磺醯基氧基、(C1-C6)鹵烷基磺醯基氧基、(C1-C6)烷基羰基、(C1-C6)鹵烷基羰基、(C1-C6)烷基羰基氧基、(C1-C6)烷氧基羰基、(C1-C6)鹵烷氧基羰基、胺基羰基、(C1-C6)烷基胺基羰基、二-(C1-C6)烷基胺基羰基、(C1-C6)鹵烷基胺基羰基、(C2-C6)烯基胺基羰基、二-(C2-C6)-烯基胺基羰基、(C3-C8)環烷基胺基羰基、(C1-C6)烷基磺醯基胺基、(C1-C6)烷基胺基、二-(C1-C6)烷基胺基、胺基磺醯基、(C1-C6)烷基胺基磺醯基、二-(C1-C6)烷基胺基磺醯基、(C1-C6)烷基亞碸亞胺基、胺基硫基羰基、(C1-C6)烷基胺基硫基羰基、二-(C1-C6)烷基胺基硫基羰基、(C3-C8)環烷基胺基、NHCO-(C1-C6)烷基、NHCO-(C1-C6)鹵烷基、N(C1-C4)烷基-CO-(C1-C6)烷基、N(C1-C4)烷基-CO-(C1-C6)鹵烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C6)鹵烷基雜芳基或(C1-C6)鹵烷基側氧基雜芳基。 Where (configuration A1) X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or configuration (3) or group Definition in state (4) or configuration (5), and A 1 is nitrogen, =N + (O - )- or =C(R 1 )-, A 2 is nitrogen, =N + (O - )- Or =C(R 2 )-, A 3 is nitrogen, =N + (O - )- or =C(R 3 )-, A 4 is nitrogen, =N + (O - )- or =C(R 4 -, A 5 is nitrogen, =N + (O - )- or =C(R 5 )-, wherein no more than two of the groups of A 1 , A 2 , A 3 , A 4 and A 5 are nitrogen And no more than one of the groups of A 1 , A 2 , A 3 , A 4 and A 5 is =N + (O - ), and R 1 , R 2 , R 3 , R 4 and R 5 are each independently Hydrogen, cyano, carboxyl, halogen, nitro, ethyl hydrazine, hydroxy, amine, SCN, SF 5 , tris-(C 1 -C 6 )alkylfluorenyl, (C 3 -C 8 )cycloalkyl (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 Haloalkyl-(C 3 -C 8 )cycloalkyl, halo-(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 ) alkyl, (C 1 -C 6) haloalkyl, (C 1 -C 6) cyanoalkyl, (C 1 -C 6) hydroxyalkyl, hydroxycarbonyl - (C 1 -C 6) - Alkoxy, (C 1 -C 6) alkoxy carbonyl group - (C 1 -C 6) alkyl, (C 1 -C 6) alkoxy, - (C 1 -C 6) alkyl, (C 2 - C 6 ) alkenyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )halynynyl, (C 2 -C 6 ) cyanoalkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 ) alkoxycarbonyl-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, (C 1 -C 6 ) Alkoxyimido group, (C 1 -C 6 ) haloalkoxyimino group, (C 1 -C 6 )alkylthio group, (C 1 -C 6 ) haloalkylthio group, (C 1 -C 6 ) alkoxy-(C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkyl Sulfosyl, (C 1 -C 6 ) haloalkylsulfinyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 ) alkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) haloalkylsulfonyl, (C 1 - C 6 ) alkoxy-(C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 ) alkyl sulfonic acyl group, (C 1 -C 6) haloalkoxy Sulfo acyl group, (C 1 -C 6) alkylcarbonyl, (C 1 -C 6) haloalkyl carbonyl, (C 1 -C 6) alkylcarbonyloxy, (C 1 -C 6) alkyl Oxycarbonyl, (C 1 -C 6 )haloalkoxycarbonyl, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, di-(C 1 -C 6 )alkylaminocarbonyl, C 1 -C 6 ) haloalkylaminocarbonyl, (C 2 -C 6 )alkenylaminocarbonyl, bis-(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 ) ring Alkylaminocarbonyl, (C 1 -C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylamino, bis-(C 1 -C 6 )alkylamino, amine sulfonate Mercapto, (C 1 -C 6 )alkylaminosulfonyl, bis-(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkylquinone, Aminothiocarbonyl, (C 1 -C 6 )alkylaminothiocarbonyl, bis-(C 1 -C 6 )alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino , NHCO-(C 1 -C 6 )alkyl, NHCO-(C 1 -C 6 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )alkyl, N (C 1 -C 4 )alkyl-CO-(C 1 -C 6 )haloalkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-( C 1 -C 6) cycloalkyl, aryl, heteroaryl, oxo heteroaryl, halo heteroaryl, Oxo heteroaryl, heteroaryl cyano, oxo cyano heteroaryl, (C 1 -C 6) haloalkyl or heteroaryl (C 1 -C 6) haloalkyl group heteroaryl-side Aryl.

更佳為式(I-A)(組態A2)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，A1 為氮或=C(R1)，A2 為氮或=C(R2)，A3 為氮或=C(R3)，A4 為氮或=C(R4)，A5 為氮或=C(R5)，其中A1、A2、A3、A4及A5之群中不超過兩個基為氮，及R1、R2、R3、R4及R5分別獨立為氫、氰基、鹵素、硝基、乙醯基、羥基、胺基、SF5-、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、 (C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C2-C4)烯基、(C2-C4)鹵烯基、(C2-C4)氰基烯基、(C2-C4)炔基、(C2-C4)鹵炔基、(C2-C4)氰基炔基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)氰基烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C6)鹵烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基硫-(C1-C4)烷基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基磺醯基氧基、(C1-C4)鹵烷基磺醯基氧基、(C1-C4)烷基羰基、(C1-C4)鹵烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、(C1-C4)鹵烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二-(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基、二-(C1-C4)烷基胺基磺醯基、NHCO-(C1-C4)烷基、N(C1-C4)烷基-CO-(C1-C4)烷基、NHCO-(C1-C6)環烷基、N(C1-C4)烷基-CO-(C1-C6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C1-C4)鹵烷基雜芳基或(C1-C4)鹵烷基側氧基雜芳基。 More preferably, in formula (IA) (configuration A2), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) Or as defined in configuration (3) or configuration (4) or configuration (5), A 1 is nitrogen or =C(R 1 ), A 2 is nitrogen or =C(R 2 ), A 3 is nitrogen Or =C(R 3 ), A 4 is nitrogen or =C(R 4 ), A 5 is nitrogen or =C(R 5 ), wherein among A 1 , A 2 , A 3 , A 4 and A 5 No more than two groups are nitrogen, and R 1 , R 2 , R 3 , R 4 and R 5 are each independently hydrogen, cyano, halogen, nitro, ethylidene, hydroxy, amine, SF 5 -, ( C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) Alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1- C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )cyanoalkenyl, (C 2 -C 4 )alkynyl (C 2 -C 4 )haloalkynyl, (C 2 -C 4 )cyanoalkynyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 ) cyanoalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 6 ) haloalkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 )alkylsulfide -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonate Mercapto, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )haloalkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 a haloalkylaminocarbonyl group, a di-(C 1 -C 4 )alkylaminocarbonyl group, a (C 1 -C 4 )alkylsulfonylamino group, a (C 1 -C 4 )alkylamino group, Di-(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonyl, bis-(C 1 -C 4 )alkylaminosulfonyl Base, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 )alkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant heteroaryl, haloaryl, halooxyheteroaryl, cyano Heteroaryl, cyano sideoxyheteroaryl, (C 1 -C 4 )haloalkylheteroaryl or (C 1 -C 4 ) haloalkyl-tertiary heteroaryl.

甚至更佳為式(I-A)(組態A3-1)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為氮或=C(R1)，A2 為氮或=C(R2)，A3 為氮或=C(R3)，A4 為氮或=C(R4)，A5 為氮或=C(R5)，其中A1、A2、A3、A4及A5之群中不超過兩個基為氮，及R1、R2、R3、R4及R5更佳係分別獨立為氫、氰基、鹵素、硝基、乙醯基、羥基、胺基、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞 胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基、二(C1-C4)烷基胺基磺醯基或鹵吡唑。 Even better (IA) (Configuration A3-1), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) or configuration (2) or the definition in configuration (3) or configuration (4) or configuration (5), and A 1 is nitrogen or =C(R 1 ), A 2 is nitrogen or =C(R 2 ), A 3 is nitrogen or =C(R 3 ), A 4 is nitrogen or =C(R 4 ), A 5 is nitrogen or =C(R 5 ), wherein A 1 , A 2 , A 3 , A 4 and A 5 group of no more than two groups is nitrogen, and R 1, R 2, R 3 , R 4 and R 5 are more preferably based independently hydrogen, cyano, halo, nitro, acetyl, hydroxy, amine , (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 - C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy -(C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 ) alkoxy group, (C 1 -C 4 ) alkoxyimino group, (C 1 -C 4 )alkylthio group, (C 1 -C 4 )haloalkylthio group, (C 1 -C 4 ) alkylsulfinyl, (C 1 -C 4 ) haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 - C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, di-(C 1 - C 4 ) alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino, (C 1 -C 4 )alkylamino, di(C 1 -C 4 )alkylamino, amine Sulfosyl, (C 1 -C 4 )alkylaminosulfonyl, di(C 1 -C 4 )alkylaminosulfonyl or halopyrazole.

更佳為式(I-A)(組態A3-2)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為氮或=C(R1)，A2 為氮或=C(R2)，A3 為氮或=C(R3)，A4 為氮或=C(R4)，A5 為氮或=C(R5)，其中A1、A2、A3、A4及A5之群中不超過兩個基為氮，及R1、R2、R3、R4及R5更佳係分別獨立為氫、氰基、鹵素、硝基、乙醯基、羥基、胺基、(C3-C6)環烷基、(C1-C4)烷基-(C3-C6)環烷基、鹵(C3-C6)環烷基、(C1-C4)烷基、(C1-C4)鹵烷基、(C1-C4)氰基烷基、(C1-C4)羥基烷基、(C1-C4)烷氧基-(C1-C4)烷基、(C1-C4)烷氧基、(C1-C4)鹵烷氧基、(C1-C4)烷氧基-(C1-C4)烷氧基、(C1-C4)烷氧基亞胺基、(C1-C4)烷基硫基、(C1-C4)鹵烷基硫基、(C1-C4)烷基亞磺醯基、(C1-C4)鹵烷基亞磺醯基、(C1-C4)烷基磺醯基、(C1-C4)鹵烷基磺醯基、(C1-C4)烷基羰基、胺基羰基、胺基硫基羰基、(C1-C4)烷基胺基羰基、二-(C1-C4)烷基胺基羰基、(C1-C4)烷基磺醯基胺基、(C1-C4)烷基胺基、二(C1-C4)烷基胺基、胺基磺醯基、(C1-C4)烷基胺基磺醯基或二(C1-C4)烷基胺基磺醯基。 More preferably, in the formula (IA) (Configuration A3-2), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration ( 2) or the definition in configuration (3) or configuration (4) or configuration (5), and A 1 is nitrogen or =C(R 1 ), A 2 is nitrogen or =C(R 2 ), A 3 is nitrogen or =C(R 3 ), A 4 is nitrogen or =C(R 4 ), A 5 is nitrogen or =C(R 5 ), wherein A 1 , A 2 , A 3 , A 4 and A 5 In the group, no more than two groups are nitrogen, and R 1 , R 2 , R 3 , R 4 and R 5 are more preferably independently hydrogen, cyano, halogen, nitro, ethylidene, hydroxy or amine. (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy- (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 Alkoxy, (C 1 -C 4 ) alkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 ) alkylsulfinyl acyl, (C 1 -C 4) alkylsulfinyl acyl halide, (C 1 -C 4) alkylsulfonyl groups, (C 1 -C 4) Alkylsulfonyl group, (C 1 -C 4) alkylcarbonyl, aminocarbonyl, amino thiocarbonyl group, (C 1 -C 4) alkylamino-carbonyl, di - (C 1 -C 4) alkoxy Aminocarbonyl, (C 1 -C 4 )alkylsulfonylamino, (C 1 -C 4 )alkylamino, bis(C 1 -C 4 )alkylamino, aminosulfonyl (C 1 -C 4 )alkylaminosulfonyl or di(C 1 -C 4 )alkylaminosulfonyl.

甚至更佳為式(I-A)(組態A4)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為氮或=C(R1)， A2 為氮或=C(R2)，A3 為氮或=C(R3)，A4 為=C(R4)，A5 為氮或=C(R5)，及R1、R2、R3、R4及R5分別獨立為氫、鹵素、(C1-C4)鹵烷基或鹵吡唑，其中較佳係R1及R2為氫，R3為氫、鹵素或(C1-C4)鹵烷基，R4為氫、鹵素或鹵吡唑，及R5為氫或鹵素。 Even better (IA) (Configuration A4), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, especially configuration (1) or configuration (2) ) or configuration (3) or configuration (4) or configuration (5), and A 1 is nitrogen or = C (R 1 ), A 2 is nitrogen or = C (R 2 ), A 3 Is nitrogen or =C(R 3 ), A 4 is =C(R 4 ), A 5 is nitrogen or =C(R 5 ), and R 1 , R 2 , R 3 , R 4 and R 5 are each independently Hydrogen, halogen, (C 1 -C 4 )haloalkyl or halopyrazole, wherein preferably R 1 and R 2 are hydrogen, R 3 is hydrogen, halogen or (C 1 -C 4 )haloalkyl, R 4 is hydrogen, halogen or halopyrazole, and R 5 is hydrogen or halogen.

特定言之，式(I-A)(組態A5-1)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為氮或=C(R1)，A2 為氮或=C(R2)，A3 為氮或=C(R3)，A4 為=C(R4)，A5 為氮或=C(R5)，及R1、R2、R3、R4及R5分別獨立為氫、三氟甲基、4-氯吡唑或氯，其中，較佳係R1及R2為氫，R3為氫、氯或三氟甲基，R4為氫、氯或4-氯吡唑，及R5為氫或氯。 In particular, in equation (IA) (configuration A5-1), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or the definition in configuration (3) or configuration (4) or configuration (5), and A 1 is nitrogen or =C(R 1 ), A 2 is nitrogen or =C(R 2 ), A 3 is nitrogen or =C(R 3 ), A 4 is =C(R 4 ), A 5 is nitrogen or =C(R 5 ), and R 1 , R 2 , R 3 , R 4 and R 5 respectively Independently hydrogen, trifluoromethyl, 4-chloropyrazole or chlorine, wherein preferably R 1 and R 2 are hydrogen, R 3 is hydrogen, chlorine or trifluoromethyl, and R 4 is hydrogen, chlorine or 4 - chloropyrazole, and R 5 is hydrogen or chlorine.

特定言之，式(I-A)(組態A5-2)中，X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義，及A1 為=C(R1)，A2 為=C(R2)，A3 為氮或=C(R3)，A4 為=C(R4)，A5 為=C(R5)，及R1、R2、R3、R4及R5 分別獨立為氫或氯。 In particular, in equation (IA) (configuration A5-2), X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or the definition in configuration (3) or configuration (4) or configuration (5), and A 1 is =C(R 1 ), A 2 is =C(R 2 ), and A 3 is nitrogen. Or =C(R 3 ), A 4 is =C(R 4 ), A 5 is =C(R 5 ), and R 1 , R 2 , R 3 , R 4 and R 5 are each independently hydrogen or chlorine.

另一項較佳實施例中，本發明係有關一種式(I-B)化合物 In another preferred embodiment, the invention relates to a compound of formula (IB)

其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義。 Where Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or configuration (3) or configuration (4) or The definition in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I-C)化合物 In another preferred embodiment, the invention relates to a compound of formula (IC)

其中Q、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義。 Where Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or configuration (3) or configuration (4) or The definition in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I-D)化合物 In another preferred embodiment, the invention relates to a compound of formula (ID)

其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義。 Where X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or configuration (3) or configuration (4) or The definition in configuration (5).

另一項較佳實施例中，本發明係有關一種式(I-E)化合物 In another preferred embodiment, the invention relates to a compound of formula (IE)

其中X、R6、R7、R8、R9、R10及n具有如上述定義，尤指組態(1)或組態(2)或組態(3)或組態(4)或組態(5)中之定義。 Where X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as defined above, in particular configuration (1) or configuration (2) or configuration (3) or configuration (4) or The definition in configuration (5).

定義中，除非另有說明，否則鹵素係選自下列各物組成之群中：氟、氯、溴與碘，較佳係選自下列各物組成之群中：氟、氯與溴。 In the definition, unless otherwise stated, the halogen is selected from the group consisting of fluorine, chlorine, bromine and iodine, preferably selected from the group consisting of fluorine, chlorine and bromine.

本發明內容中，除非另有不同定義，否則術語「烷基」不論本身或與其他術語組合，例如：鹵烷基，咸了解係指具有1至12個碳原子且可能為分支或未分支之飽和脂系烴基。C1-C12-烷基實例為甲基、乙基、正丙基、異丙基、正丁基、異丁基、第二丁基、第三丁基、正戊基、異戊基、新戊基、第三戊基、1-甲基丁基、2-甲基丁基、1-乙基丙基、1,2-二甲基丙基、己基、正庚基、正辛基、正壬基、正癸基、正十一碳烷基與正十二碳烷基。 In the context of the present invention, the term "alkyl", whether by itself or in combination with other terms, such as haloalkyl, is understood to mean having from 1 to 12 carbon atoms and possibly branched or unbranched, unless otherwise defined. Saturated aliphatic hydrocarbon group. Examples of C 1 -C 12 -alkyl are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, tert-butyl, n-pentyl, isopentyl, Neopentyl, third amyl, 1-methylbutyl, 2-methylbutyl, 1-ethylpropyl, 1,2-dimethylpropyl, hexyl, n-heptyl, n-octyl, N-decyl, n-decyl, n-undecyl and n-dodecyl.

根據本發明，除非另有不同定義，否則術語「烯基」不論本身或與其他術語組合，咸了解係指具有至少一個雙鍵之直鏈或分支之C2-C12-烯基，例如：乙烯基、烯丙基、1-丙烯基、異丙烯基、1-丁烯基、2-丁烯基、3-丁烯基、1,3-丁二烯基、1-戊烯基、2-戊烯基、3-戊烯基、4-戊烯基、1,3-戊二烯基、1-己烯基、2-己烯基、3-己烯基、4-己烯基、5-己烯基與1,4-己二烯基。 According to the present invention, unless otherwise defined differently, the term "alkenyl", whether by itself or in combination with other terms, refers to a C 2 -C 12 -alkenyl group having at least one double bond or a straight chain or branch, for example: Vinyl, allyl, 1-propenyl, isopropenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1,3-butadienyl, 1-pentenyl, 2 -pentenyl, 3-pentenyl, 4-pentenyl, 1,3-pentadienyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl and 1,4-hexadienyl.

根據本發明，除非另有不同定義，否則術語「炔基」不論本身或與其他術語組合，咸了解係指具有至少一個參鍵之直鏈或分支之C2-C12-炔基，例如：乙炔基、1-丙炔基、與炔丙基。炔基亦可包含至少一個雙鍵。 According to the present invention, unless otherwise defined differently, the term "alkynyl", whether by itself or in combination with other terms, refers to a C 2 -C 12 -alkynyl group having at least one linear or branched bond of a bond, for example: Ethynyl, 1-propynyl, and propargyl. An alkynyl group can also contain at least one double bond.

根據本發明，除非另有說明，否則術語「環烷基」不論本身或與其他術語組合，咸了解係指C3-C8-環烷基，例如：環丙基、環丁基、環戊基、環己基、環庚基與環辛基。 According to the present invention, unless otherwise indicated, the term "cycloalkyl", whether by itself or in combination with other terms, means C 3 -C 8 -cycloalkyl, for example: cyclopropyl, cyclobutyl, cyclopentane. Base, cyclohexyl, cycloheptyl and cyclooctyl.

術語「烷氧基」不論本身或與其他術語組合，例如：鹵烷氧基，咸了解係指O-烷基，其中術語「烷基」如上述定義。 The term "alkoxy", whether by itself or in combination with other terms, such as haloalkoxy, is understood to mean O-alkyl, wherein the term "alkyl" is as defined above.

根據本發明，除非另有不同定義，否則術語「芳基」咸了解係指具有6至14個碳原子之芳香族基團。較佳為苯基、萘基、蒽基或菲基，更佳為苯基。 According to the present invention, the term "aryl" is understood to mean an aromatic group having 6 to 14 carbon atoms unless otherwise defined. Phenyl, naphthyl, anthracenyl or phenanthryl is preferred, and phenyl is more preferred.

除非另有不同定義，否則術語「芳基烷基」咸了解係指根據本發明基團「芳基」與「烷基」定義之組合，其中該基團一般係利用烷基附接。此等實例為苯甲基、苯基乙基或α-甲基苯甲基，以苯甲基特別 佳。 Unless otherwise defined differently, the term "arylalkyl" is used in the context of the definition of the group "aryl" and "alkyl" according to the invention, wherein the group is typically attached using an alkyl group. These examples are benzyl, phenylethyl or alpha-methylbenzyl, especially preferably benzyl.

除非另有不同定義，否則術語「雜芳基」係指碳原子與至少一個雜原子組成之單環、二環或三環雜環基團，其中至少一個環為芳香族。較佳係雜芳基包含3、4、5、6、7或8個碳原子，其係選自下列之群中：呋喃基、噻吩基、吡咯基、吡唑基、咪唑基、1,2,3-三唑基、1,2,4-三唑基、唑基、異唑基、噻唑基、異噻唑基、1,2,3-二唑基、1,2,4-二唑基、1,3,4-二唑基、1,2,5-二唑基、1,2,3-噻二唑基、1,2,4-噻二唑基、1,3,4-噻二唑基、1,2,5-噻二唑基、吡啶基、嘧啶基、嗒基、吡基、1,2,3-三基、1,2,4-三基、1,3,5-三基、苯并呋喃基、苯并異呋喃基、苯并噻吩基、苯并異噻吩基、吲哚基、異吲哚基、吲唑基、苯并噻唑基、苯并異噻唑基、苯并唑基、苯并異唑基、苯并咪唑基、2,1,3-苯并二唑、喹啉基、異喹啉基、噌啉基、酞基、喹唑啉基、喹啉基、萘啶基、苯并三基、嘌呤基、蝶啶基、咪唑并嘧啶基、與吲哚基。 Unless otherwise defined differently, the term "heteroaryl" refers to a monocyclic, bicyclic or tricyclic heterocyclic group of carbon atoms and at least one heteroatom, at least one of which is aromatic. Preferably, the heteroaryl group contains 3, 4, 5, 6, 7, or 8 carbon atoms selected from the group consisting of furyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, 1,2 , 3-triazolyl, 1,2,4-triazolyl, Azolyl, different Azyl, thiazolyl, isothiazolyl, 1,2,3- Diazolyl, 1,2,4- Diazolyl, 1,3,4- Diazolyl, 1, 2, 5- Diazolyl, 1,2,3-thiadiazolyl, 1,2,4-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,5-thiadiazolyl, pyridyl Pyrimidine group Base Base, 1, 2, 3-three Base, 1, 2, 4-three Base, 1, 3, 5 - three Benzofuranyl, benzoisofuranyl, benzothienyl, benzisothienyl, fluorenyl, isodecyl, oxazolyl, benzothiazolyl, benzisothiazolyl, benzo Azolyl, benzopyrene Azolyl, benzimidazolyl, 2,1,3-benzo Diazole, quinolyl, isoquinolinyl, porphyrinyl, anthracene Base, quinazolinyl, quin Lolinyl, naphthyridyl, benzotrien Base, fluorenyl, pteridinyl, imidazopyrimidinyl, and hydrazine base.

經鹵素取代之基團，例如：鹵烷基，係經單取代或多取代，至高達可能取代基之最大數量。若經多鹵化時，鹵原子可相同或不同。除非另有說明，否則該可視需要經取代之基團可經單-或多取代，其中多取代代時之取代基可相同或不同。 Halogen-substituted groups, such as haloalkyl groups, are mono- or poly-substituted up to the maximum number of possible substituents. If polyhalogenated, the halogen atoms may be the same or different. Unless otherwise indicated, the group optionally substituted may be mono- or polysubstituted, wherein the substituents in the case of multiple substitutions may be the same or different.

式(I)化合物可能隨其取代基性質而定，而呈幾何與/或光學活性異構物或不同組成之相應異構物混合物型式。此等立體異構物為例如：對映異構物、非對映異構物、滯轉異構物或幾何異構物。因此本發明包括純的立體異構物及此等異構物之任何所需混合物。式(I)化合物亦可呈鹽型，特定言之酸加成鹽與金屬鹽錯化物。式(I)化合物及其酸加成鹽與金屬鹽錯化物具有良好效力，尤指控制動物害蟲。 The compound of formula (I) may be a geometrically and/or optically active isomer or a corresponding mixture of isomers of different composition depending on the nature of the substituent. Such stereoisomers are, for example, enantiomers, diastereomers, ligation isomers or geometric isomers. Thus the invention includes both pure stereoisomers and any desired mixtures of such isomers. The compounds of formula (I) may also be in the form of a salt, in particular an acid addition salt and a metal salt. The compounds of formula (I) and their acid addition salts and metal salt complexes have good potency, especially for controlling animal pests.

通式(I)化合物之合適鹽類包括習知之無毒性鹽類，亦即與適當鹼類形成之鹽類及與酸之加成鹽類。較佳係與無機鹼類形成之鹽類，如：鹼金屬鹽類(例如：鈉、鉀或銫鹽類)、鹼土金屬鹽類(例如：鈣或鎂鹽類)、銨鹽類、與有機鹼形成之鹽類及與無機胺形成之鹽類(例如：三乙基銨、二環己基銨、N,N’-二苯甲基伸乙基二銨、吡啶鎓、甲基吡啶鎓 或乙醇銨鹽類)、與無機酸形成之鹽類(例如：鹽酸鹽、氫溴酸鹽、硫酸二氫鹽、硫酸三氫鹽、或磷酸鹽)、與有機羧酸或有機磺酸形成之鹽類(例如：甲酸鹽、乙酸鹽、三氟乙酸鹽、馬來酸鹽、酒石酸鹽、甲磺酸鹽、苯磺酸鹽或對甲苯磺酸鹽)、與鹼性胺基酸形成之鹽類(例如：精胺酸鹽、天冬胺酸鹽或麩胺酸鹽)，及諸如此類。 Suitable salts of the compounds of the general formula (I) include the conventional non-toxic salts, that is, salts formed with suitable bases and addition salts with acids. Preferred are salts formed with inorganic bases such as alkali metal salts (for example: sodium, potassium or barium salts), alkaline earth metal salts (for example: calcium or magnesium salts), ammonium salts, and organic a salt formed by a base and a salt formed with an inorganic amine (for example, triethylammonium, dicyclohexylammonium, N,N'-dibenzylmethylethylammonium, pyridinium, methylpyridinium or ethanol) Ammonium salts), salts formed with inorganic acids (eg, hydrochloride, hydrobromide, dihydrogen sulfate, trihydrogen sulfate, or phosphate), salts with organic or organic sulfonic acids a salt (for example, formate, acetate, trifluoroacetate, maleate, tartrate, methanesulfonate, besylate or p-toluenesulfonate), a salt formed with a basic amino acid Class (eg, arginine, aspartate or glutamate), and the like.

本發明式(I)化合物可採用下列反應圖所示製程製得： The compound of the formula (I) of the present invention can be obtained by the process shown in the following reaction scheme:

製程AProcess A

製備式(I)中X為H1、H2、H3、H4、H5、H6、H7、H8、H13、H14或H15之化合物之一般製程係參照實例H2、H4或H7說明於下文中。 A general process for the preparation of a compound of formula (I) wherein X is H1, H2, H3, H4, H5, H6, H7, H8, H13, H14 or H15 is described below with reference to Examples H2, H4 or H7.

Q、R6、R7、R8、R9基團具有如上述定義，A6為-N-R10、O或S，其中R10具有如上述定義，X1為鹵素，及R11為(C1-C4)烷基。 The Q, R 6 , R 7 , R 8 , R 9 groups have the definitions as defined above, and A 6 is —NR 10 , O or S, wherein R 10 has the above definition, X 1 is halogen, and R 11 is (C) 1 -C 4 )alkyl.

步驟a)Step a)

式(VI)中R7為氫之化合物之製法可例如：由式(II)醛與式(III)酯，類似Journal of Organic Chemistry,80(2015)2529-2538,Tetrahedron Letters,36(1995),8107-8110或European Journal of Organic Chemistry,35(2011),7199-7206說明之製程反應。式(VII)醛可自商品取得或可採用已知方法製備，例如：類似Houben-Weyl,Methoden der organischen Chemie[Methods of Organic Chemistry],volume E 3：Aldehyde[Aldehydes],Thieme Verlag說明之製程。式(III)酯可自商品取得或可採用已知方法製備，例如：類似US2005/222458、US2013/296602、WO2011/126688、Synthesis,47(2015),3542-3552或Tetrahedron Letters,43(2002),879-882說明之製程。 The preparation of a compound of the formula (VI) wherein R 7 is hydrogen can be, for example, an aldehyde of the formula (II) and an ester of the formula (III), similar to Journal of Organic Chemistry, 80 (2015) 2529-2538, Tetrahedron Letters, 36 (1995). , Process Processes as described in 8107-8110 or European Journal of Organic Chemistry, 35 (2011), 7199-7206. The aldehyde of the formula (VII) can be obtained commercially or by a known method, for example, a process similar to that described by Houben-Weyl, Methoden der organischen Chemie [Methods of Organic Chemistry], volume E 3: Aldehyde [Aldehydes], Thieme Verlag. The ester of formula (III) can be obtained commercially or can be prepared by known methods, for example: similar to US 2005/222458, US 2013/296602, WO 2011/126688, Synthesis, 47 (2015), 3542-3552 or Tetrahedron Letters, 43 (2002). , 879-882 illustrates the process.

步驟b)Step b)

式(VI)中R7具有如上述定義，但不為氫之化合物，其製法可由式(IV)化合物與式(V)炔類似Journal of Organic Chemistry,68(2003)9310-9316、Journal of Organic Chemistry,68(2003),9310-9316、Tetrahedron Letters,40(1999)627-630、Journal of Organic Chemistry,67(2002),5382-5385或Journal of the Chemical Society,Perkin Transactions 1：Organic and Bio-Organic Chemistry(1972-1999),1981,1329-1338說明之製程反應。式(IV)化合物可自商品取得或可採用已知方法製備，例如：類似Houben-Weyl,Methoden der organischen Chemie,volume 7/2a及b：Ketone[Ketones],Thieme Verlag說明之製程。式(V)炔可自商品取得或可採用已知方法製備，例如：類似Journal of the American Chemical Society,110(1988)3965、Journal of the American Chemical Society,(106)1984,1029-1040、European Journal of Organic Chemistry,(2015)7602-7611或Angewandte Chemie-International Edition,53(2014),4154-4158說明之製程。 R 7 in the formula (VI) has a compound as defined above, but is not hydrogen, and can be produced by a compound of the formula (IV) similar to the alkyne of the formula (V). Journal of Organic Chemistry, 68 (2003) 9310-9316, Journal of Organic Chemistry, 68 (2003), 9310-9316, Tetrahedron Letters, 40 (1999) 627-630, Journal of Organic Chemistry, 67 (2002), 5382-5385 or Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio- The process of the process described by Organic Chemistry (1972-1999), 1981, 1329-1338. The compound of the formula (IV) can be obtained commercially or by a known method, for example, a process similar to that described by Houben-Weyl, Methoden der organischen Chemie, volume 7/2a and b: Ketone [Ketones], Thieme Verlag. The alkyne of formula (V) can be obtained commercially or can be prepared by known methods, for example, similar to Journal of the American Chemical Society, 110 (1988) 3965, Journal of the American Chemical Society, (106) 1984, 1029-1040, European. The process described in Journal of Organic Chemistry, (2015) 7602-7611 or Angewandte Chemie-International Edition, 53 (2014), 4154-4158.

步驟c、d、e)Steps c, d, e)

由式(VI)酯先採用標準方法，例如：使用溴化氫或四溴甲烷，於三 苯基膦之存在下轉化成式(VII)化合物；參見Tetrahedron Letters,36(1995),8107-8110、Journal of Organic Chemistry,68(2003),792-798、Tetrahedron Letters,55(2014),2075-2077或Helvetica Chimica Acta,89(2006),1417-1421。 The ester of formula (VI) is first converted to the compound of formula (VII) by the use of standard methods such as hydrogen bromide or tetrabromomethane in the presence of triphenylphosphine; see Tetrahedron Letters, 36 (1995), 8107-8110, Journal of Organic Chemistry, 68 (2003), 792-798, Tetrahedron Letters, 55 (2014), 2075-2077 or Helvetica Chimica Acta, 89 (2006), 1417-1421.

隨後，由式(VII)化合物與式(VIII)甲硫醇，於鹼(例如：氫氧化鈉或N,N-二異丙基乙基胺)之存在下，類似Synthetic Communications,28(1998),2601-2611或Advanced Synthesis及Catalysis,357(2015),829-833說明之製程反應，轉化成硫衍生物(IX)。 Subsequent to the synthesis of a compound of formula (VII) with a methyl mercaptan of formula (VIII) in the presence of a base (eg sodium hydroxide or N,N-diisopropylethylamine), similar to Synthetic Communications, 28 (1998) , Process Conversion of 2601-2611 or Advanced Synthesis and Catalysis, 357 (2015), 829-833, converted to a sulfur derivative (IX).

式(IX)硫衍生物之酯可採用標準方法(參見例如：WO2006/7700、EP861831或Journal of Organic Chemistry,73(2008),3714-3724)，例如：使用鹼金屬氫氧化物作為鹼(如：氫氧化鈉或氫氧化鋰)，於作為溶劑之醇(例如：甲醇或乙醇)中轉化成式(X)酸。 The ester of the sulfur derivative of the formula (IX) can be used in a standard method (see, for example, WO2006/7700, EP861831 or Journal of Organic Chemistry, 73 (2008), 3714-3724), for example, using an alkali metal hydroxide as a base (e.g. : sodium hydroxide or lithium hydroxide), converted to an acid of the formula (X) in an alcohol (for example, methanol or ethanol) as a solvent.

步驟f)Step f)

式(I，n=0)化合物可由式(X)化合物與式(XI)化合物，於縮合劑之存在下製備。 Compounds of formula (I, n = 0) can be prepared from compounds of formula (X) and compounds of formula (XI) in the presence of a condensing agent.

式(XI)化合物可自商品取得或可採用已知方法製備，例如：類似WO 2010/125985,WO 2012/074135,WO 2012/086848,WO 2013/018928,WO 2015/000715,WO 2015/121136,WO2016/039441,WO2016/059145及WO2016/071214說明之製程。 The compound of the formula (XI) can be obtained commercially or can be prepared by known methods, for example, similar to WO 2010/125985, WO 2012/074135, WO 2012/086848, WO 2013/018928, WO 2015/000715, WO 2015/121136, The processes described in WO2016/039441, WO2016/059145 and WO2016/071214.

形成式(I，n=0)化合物之轉化法可在無溶劑或在溶劑中進行，該反應較佳係於選自在有利之反應條件下呈惰性之習知溶劑中進行。較佳為醚類，例如：二異丙基醚、二烷、四氫呋喃、1,2-二甲氧基乙烷、第三丁基甲基醚；鹵化烴類，例如：二氯甲烷、氯仿、四氯化碳、1,2-二氯乙烷或氯苯；醇類，如：甲醇、乙醇或異丙醇；腈類，例如：乙腈或丙腈；芳香烴類，例如：甲苯或二甲苯；非質子性極性溶劑，例如：N,N-二甲基甲醯胺或N-甲基吡咯啶酮、或氮化合物，例如：吡啶。 The conversion method for forming a compound of the formula (I, n = 0) can be carried out in the absence of a solvent or in a solvent, and the reaction is preferably carried out in a conventional solvent selected from the group which is inert under favorable reaction conditions. Preferred are ethers such as diisopropyl ether, two Alkane, tetrahydrofuran, 1,2-dimethoxyethane, tert-butyl methyl ether; halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane or chlorobenzene; Alcohols such as: methanol, ethanol or isopropanol; nitriles such as acetonitrile or propionitrile; aromatic hydrocarbons such as toluene or xylene; aprotic polar solvents such as N, N-dimethyl Indoleamine or N-methylpyrrolidone, or a nitrogen compound such as pyridine.

合適縮合劑實例為碳化二亞胺類，如：1-(3-二甲基胺基丙基)-3-乙基碳化二亞胺鹽酸鹽(EDCI)或1,3-二環己基碳化二亞胺；酸酐，如：乙酸酐、三氟乙酸酐；三苯基膦、鹼與四氯化碳之混合物、或三苯基膦與偶氮二酯(例如：偶氮二羧酸二乙酯)之混合物。 Examples of suitable condensing agents are carbodiimides such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) or 1,3-dicyclohexylcarbylation. Diimine; anhydride, such as: acetic anhydride, trifluoroacetic anhydride; triphenylphosphine, a mixture of a base and carbon tetrachloride, or a triphenylphosphine with an azodiester (eg, azodicarboxylic acid diethyl a mixture of esters).

該反應可於酸或鹼之存在下進行。 This reaction can be carried out in the presence of an acid or a base.

所說明反應可使用之酸實例為磺酸，如：甲烷磺酸或對甲苯磺酸；羧酸(如：乙酸)、或聚磷酸。 Examples of acids which can be used in the illustrated reactions are sulfonic acids such as methanesulfonic acid or p-toluenesulfonic acid; carboxylic acids such as acetic acid, or polyphosphoric acid.

合適鹼類實例為氮雜環，如：吡啶、甲基吡啶、2,6-二甲基吡啶、1,8-重氮雙環[5.4.0]-7-十一碳烯(DBU)；三級胺類，如：三乙基胺及N,N-二異丙基乙基胺；無機鹼類，如：磷酸鉀、碳酸鉀及氫化鈉。 Examples of suitable bases are nitrogen heterocycles such as: pyridine, picoline, 2,6-lutidine, 1,8-diazabicyclo[5.4.0]-7-undecene (DBU); Amines such as triethylamine and N,N-diisopropylethylamine; inorganic bases such as potassium phosphate, potassium carbonate and sodium hydride.

該反應可於合適觸媒(例如：1-羥基苯并三唑)之存在下進行。 This reaction can be carried out in the presence of a suitable catalyst such as 1-hydroxybenzotriazole.

步驟g)Step g)

式(I，n=2)化合物可由式(I，n=0)化合物氧化製得。該氧化反應通常在溶劑中進行。較佳為鹵化烴類，例如：二氯甲烷、氯仿、四氯化碳、1,2-二氯乙烷或氯苯；醇類，如：甲醇或乙醇；甲酸、乙酸、丙酸或水。 Compounds of formula (I, n = 2) can be prepared by oxidation of a compound of formula (I, n = 0). This oxidation reaction is usually carried out in a solvent. Preferred are halogenated hydrocarbons such as dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane or chlorobenzene; alcohols such as methanol or ethanol; formic acid, acetic acid, propionic acid or water.

合適氧化劑實例為過氧化氫及間氯過苯甲酸。 Examples of suitable oxidizing agents are hydrogen peroxide and m-chloroperbenzoic acid.

Q基團可在上述製程之後利用自文獻中已知之方法進一步官能基化。 The Q group can be further functionalized after the above process using methods known in the literature.

製程BProcess B

製備式(I)中X為H9、H10、H11或H12之化合物之一般製程係參照實例H11說明於下文中。 A general process for the preparation of a compound of formula (I) wherein X is H9, H10, H11 or H12 is illustrated below with reference to Example H11.

Q、R6、R7、R8、R9基團具有如上述定義，及X1為鹵素， The Q, R 6 , R 7 , R 8 , R 9 groups have the definitions as defined above, and X 1 is halogen,

步驟a)Step a)

式(X)羧酸可類似US9108905或Organic Letters,11(2009)1023-1026中說明之製程，於O,N-二甲基羥基胺鹽酸鹽之存在下，於縮合劑之存在下，轉化成式(XII)溫瑞伯醯胺(Weinreb amide)。 The carboxylic acid of formula (X) can be converted in the presence of a condensing agent in the presence of a condensing agent in the presence of O,N-dimethylhydroxylamine hydrochloride, similar to the process described in US 9108905 or Organic Letters, 11 (2009) 1023-1026 Form (XII) Weinreb amide.

形成式(XII)化合物之轉化法較佳係於選自在有利之反應條件下呈惰性之習知溶劑中進行。較佳為腈類，例如：乙腈或丙腈，或非質子性極性溶劑，例如：N,N-二甲基甲醯胺或N-甲基吡咯啶酮。 The conversion method for forming the compound of the formula (XII) is preferably carried out in a conventional solvent selected from the group which is inert under favorable reaction conditions. Preferred are nitriles such as acetonitrile or propionitrile or an aprotic polar solvent such as N,N-dimethylformamide or N-methylpyrrolidone.

合適縮合劑實例為碳化二亞胺類，如：1-(3-二甲基胺基丙基)-3-乙基碳化二亞胺鹽酸鹽(EDCI)及1,3-二環己基碳化二亞胺，酸酐類，如：乙酸酐及三氟乙酸酐或氯甲酸異丁基酯。 Examples of suitable condensing agents are carbodiimides such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 1,3-dicyclohexylcarbylation. Diimine, anhydrides such as acetic anhydride and trifluoroacetic anhydride or isobutyl chloroformate.

該反應可在鹼之存在下進行，例如：三乙基胺或N-甲基嗎啉。 The reaction can be carried out in the presence of a base such as triethylamine or N -methylmorpholine.

步驟b)Step b)

式(XII)溫瑞伯醯胺可於甲基鋰或甲基鎂鹵化物(例如：甲基鎂化溴)之存在下，類似Journal of Medicinal Chemistry,38(1995)4972-4975或Organic Letters,14(2012)6158-6161說明之製程轉化成式(XIII)酮。 The formula (XII) of Wermine oxime can be in the presence of methyllithium or methylmagnesium halide (for example: methylmagnesium bromide), similar to Journal of Medicinal Chemistry, 38 (1995) 4972-4975 or Organic Letters, 14 ( The process described in 2012) 6158-6161 is converted to a ketone of formula (XIII).

式(XIII)化合物之轉化法係於選自在有利之反應條件下呈惰性之習知溶劑中進行。較佳為醚類，例如：四氫呋喃或乙醚。 The conversion of the compound of formula (XIII) is carried out in a conventional solvent selected from the group consisting of inert solvents under advantageous reaction conditions. Preferred are ethers such as tetrahydrofuran or diethyl ether.

步驟c)Step c)

式(XIII)酮可使用二異丙基胺化鋰(LDA)，於四氫呋喃中脫除質子，由所形成之烯醇鹽與三甲基矽基氯(TMSCl)反應，隨後由矽基烯醇醚進行α-鹵化(例如：使用N-琥珀醯亞胺(NBS))，例如：類似Chemistry-A European Journal,17(2011)4839-4848說明之製程，轉化成式(XIV)化合物。 The ketone of the formula (XIII) can be obtained by using lithium diisopropylamide (LDA), removing protons in tetrahydrofuran, reacting the formed enolate with trimethylsulfonyl chloride (TMSCl), followed by mercapto enol. The ether is subjected to alpha-halogenation (for example, using N -succinimide (NBS)), for example, a process similar to that described in Chemistry-A European Journal, 17 (2011) 4839-4848, which is converted to a compound of formula (XIV).

或者，由式(XIII)酮，亦可使用自文獻中已知其他α-鹵化法進行，例如：類似US2006/52378,WO2005/7631,US2012/214791或US4544664說明之製程。 Alternatively, from the ketone of formula (XIII), it can be carried out using other alpha-halogenation methods known from the literature, for example, a process similar to that described in US 2006/52378, WO 2005/7631, US 2012/214791 or US 4,454,664.

步驟d)Step d)

式(I，n=0)化合物可由式(XIV)化合物使用式(XV)胺環化製得。該環化反應係例如：於乙醇、乙腈或N,N-二甲基甲醯胺中，採用類似例如：WO2005/66177、WO2012/88411、WO2013/3298、US2009/203705、US2012/258951、WO2012/168733、WO2014/187762或J.Med.Chem.31(1988)1590-1595中說明之已知方法進行。 Compounds of formula (I, n = 0) can be prepared by cyclizing a compound of formula (XIV) using an amine of formula (XV). The cyclization reaction is, for example, in ethanol, acetonitrile or N,N-dimethylformamide, and is similar to, for example, WO2005/66177, WO2012/88411, WO2013/3298, US2009/203705, US2012/258951, WO2012/ The known methods described in 168733, WO 2014/187762 or J. Med. Chem. 31 (1988) 1590-1595 are carried out.

式(XV)化合物可自商品取得。 Compounds of formula (XV) are available from commercial sources.

步驟e)Step e)

式(I，n=0)化合物形成式(I，n=2)化合物之轉化法係類似製程A，步驟g)進行。 The conversion of the compound of formula (I, n = 0) to form a compound of formula (I, n = 2) is analogous to process A, step g).

Q基團亦可在上述製程之後利用自文獻中已知之方法進一步官能基化。 The Q group can also be further functionalized after the above process using methods known in the literature.

方法與用途Method and use

本發明亦有關控制動物害蟲之方法，其中由式(I)化合物作用在動物害蟲與/或其棲息地上。動物害蟲之控制較佳係在農業與森林，及材料保護上進行。較佳係不包括人體或動物體之手術或治療處理之方法 及在人體或動物體上進行之診斷方法。本發明進一步有關一種以式(I)化合物作為殺害蟲劑，尤指作為作物保護組成物之用途。 The invention also relates to a method of controlling an animal pest in which a compound of formula (I) acts on an animal pest and/or its habitat. The control of animal pests is preferably carried out in agriculture and forests, as well as in material protection. Preferably, it does not include a surgical or therapeutic treatment of the human or animal body and a diagnostic method performed on the human or animal body. The invention further relates to the use of a compound of formula (I) as a pesticidal agent, especially as a crop protection composition.

本申請案內容中，術語「殺害蟲劑」在各例中亦總是包括術語「作物保護組成物」。 In the context of this application, the term "killing agent" also always includes the term "crop protection composition" in each case.

式(I)化合物具有良好之植物耐受性、對恆溫動物有利之毒性及良好之環境相容性，適合保護植物與植物器官來對抗生物性與非生物性逆境壓力因子、提高收成產量、改進收成材料品質、及控制動物害蟲，尤指出現在農業、園藝、動物畜養、水產養殖、森林、花園與休閒設施之昆蟲、蜘蛛、蠕蟲，尤指線蟲與軟體動物，可用於保護庫存產品與材料，及用於衛生領域。 The compound of formula (I) has good plant tolerance, favorable toxicity to warm-blooded animals and good environmental compatibility, and is suitable for protecting plants and plant organs against biological and abiotic stress stress factors, increasing yield, and improving The quality of harvested materials and the control of animal pests, especially in the fields of agriculture, horticulture, animal husbandry, aquaculture, forests, gardens and leisure facilities, insects, spiders, worms, especially nematodes and mollusks, can be used to protect stock products and materials. And for the health sector.

本申請案內容中，應了解術語「衛生」係指目的在於預防疾病(尤指感染性疾病)及用於保護人類與動物健康及/或保護環境及/或維持清潔之任何及所有措施、方法與過程。根據本發明，其特別包括例如：紡織品或硬表面(尤指由玻璃、木材、水泥、陶、瓷、塑膠或金屬(類)製成之表面)之清潔、消毒與殺菌之措施，以確保沒有有害衛生的生物及/或其分泌物。根據本發明此態樣之保護範圍較佳係不包括應用在人體或動物體之手術或治療處理及在人體或動物體上進行之診斷方法。 In the context of this application, it should be understood that the term "hygienic" refers to any and all measures and methods aimed at preventing diseases (especially infectious diseases) and for protecting human and animal health and/or protecting the environment and/or maintaining cleanliness. With the process. According to the invention, it comprises, inter alia, measures for the cleaning, disinfection and sterilization of textiles or hard surfaces, in particular surfaces made of glass, wood, cement, ceramic, porcelain, plastic or metal, to ensure that no Harmful organisms and/or their secretions. Preferably, the scope of protection according to this aspect of the invention does not include surgical or therapeutic treatment applied to the human or animal body and diagnostic methods performed on the human or animal body.

術語「衛生領域」包括以此等衛生措施、方法與過程為重點之所有區域、技術領域與工業應用，例如：廚房、烘焙坊、機場、浴室、游泳池、百貨公司、旅館、醫院、畜養棚、動物飼養，等等之衛生。因此咸了解術語「衛生害蟲」係指出現在衛生領域中造成問題(尤指造成健康問題)之一或多種動物害蟲。因此其主要目的係在衛生領域中避免或限制到最低程度之衛生害蟲之出現及/或與其之接觸。尤其可透過使用殺害蟲劑達成此點，其可同時用於預防害蟲入侵及預防現存之害蟲入侵。亦可能使用可防止或減少接觸到害蟲之調配物。衛生害蟲包括例如：下述生物體。 The term “health area” includes all areas, technical areas and industrial applications that focus on such hygiene measures, methods and processes, such as kitchens, bakeries, airports, bathrooms, swimming pools, department stores, hotels, hospitals, livestock sheds, Animal feeding, etc. Therefore, the term "sanitary pests" is used to refer to one or more animal pests that cause problems (especially health problems) in the health field. The primary objective therefore is to avoid or limit the occurrence and/or exposure of minimally occurring sanitary pests in the health sector. This can be achieved, inter alia, by the use of insecticides, which can be used simultaneously to prevent pest infestation and to prevent the infestation of existing pests. It is also possible to use a formulation that prevents or reduces exposure to pests. Hygienic pests include, for example, the following organisms.

因此術語「衛生保護」包括所有用於維持及/或改善此等衛生措施、方法與製程之作用。 The term "hygiene protection" therefore includes all the functions used to maintain and/or improve such hygiene measures, methods and processes.

式(I)化合物較佳係作為殺害蟲劑使用。其等有活性對抗正常敏感 性與抗性物種，及對抗所有或特定發展階段。上述害蟲包括：節肢動物門(Arthropoda)，尤指蛛形綱(Arachnida)之害蟲，例如：粗腳粉蟎屬(Acarus spp.)(例如：粉塵蟎(Acarus siro))、枸杞瘤節蜱(Aceria kuko)、桔瘤節蜱(Aceria sheldoni)、刺皮癭蟎屬(Aculops spp.)、刺癭蟎屬(Aculus spp.)(例如：福氏刺節蜱(Aculus fockeui)、蘋果銹蜱(Aculus schlechtendali))、花蜱屬(Amblyomma spp.)、橫紋葉蟎(Amphitetranychus viennensis)、銳緣蜱屬(Argas spp.)、牛蜱屬(Boophilus spp.)、紅鬚蟎屬(Brevipalpus spp.)(例如：紫紅短鬚蟎(Brevipalpus phoenicis))、禾草苔蟎(Bryobia graminum)、苜蓿苔蟎(Bryobia praetiosa)、刺尾蠍屬(Centruroides spp.)、恙蟎屬(Chorioptes spp.)、雞皮刺蟎(Dermanyssus gallinae)、羽刺皮癬蟎(Dermatophagoides pteronyssinus)、美洲塵蟎(Dermatophagoides farinae)、革蜱屬(Dermacentor spp.)、始葉蟎屬(Eotetranychus spp.)(例如：核桃始葉蟎(Eotetranychus hicoriae))、梨上癭蟎(Epitrimerus pyri)、真葉蟎屬(Eutetranychus spp.)(例如：斑氏真葉蟎(Eutetranychus banksi))、癭蟎屬(Eriophyes spp.)(例如：梨癭蟎(Eriophyes pyri))、家食甜蟎(Glycyphagus domesticus)、足海鐮螯蟎(Halotydeus destructor)、半跗線蟎屬(Hemitarsonemus spp.)(例如：茶塵蟎(Hemitarsonemus latus)(=多食細蟎(Polyphagotarsonemus latus))、璃眼蜱屬(Hyalomma spp.)、硬蜱屬(Ixodes spp.)、球腹蛛屬(Latrodectus spp.)、褐隱蛛屬(Loxosceles spp.)、秋收恙蟎(Neutrombicula autumnalis)、Nuphersa屬、小爪蟎屬(Oligonychus spp.)(例如：咖啡小爪蟎(Oligonychus coffee)、針葉小爪蟎(Oligonychus coniferarum)、冬青小爪蟎(Oligonychus ilicis)、甘蔗小爪蟎(Oligonychus indicus)、芒果小爪蟎(Oligonychus mangiferus)、草地小爪蟎(Oligonychus pratensis)、石榴小爪蟎(Oligonychus punicae)、樟小爪蟎(Oligonychus yothersi))、鈍緣蜱屬(Ornithodorus spp.)、巨刺蟎屬(Ornithonyssus spp.)、紅蜘蛛屬(Panonychus spp.)(例如：桔全爪蟎(Panonychus citri)(=柑桔葉蟎(Metatetranychus citri))、榆全爪蟎(Panonychus ulmi)(=歐洲葉蟎(Metatetranychus ulmi)))、橘鏽蟎(Phyllocoptruta oleivora)、雜食葉蟎(Platytetranychus multidigituli)、多食細蟎(Polyphagotarsonemus latus)、 癢蟎屬(Psoroptes spp.)、扇頭蜱屬(Rhipicephalus spp.)、根蟎屬(Rhizoglyphus spp.)、人疥蟎屬(Sarcoptes spp.)、蠍(Scorpio maurus)、狹跗線蟎屬(Stenotarsonemus spp.)、稻細蟎(Steneotarsonemus spinki)、細蟎屬(Tarsonemus spp.)(例如：亂跗線蟎(Tarsonemus confusus)、仙克萊細蟎(Tarsonemus pallidus))、紅葉蟎屬(Tetranychus spp.)(例如：加拿大葉蟎(Tetranychus canadensis)、赤葉蟎(Tetranychus cinnabarinus)、土耳其斯坦葉蟎(Tetranychus turkestani)、二斑葉蟎(Tetranychus urticae))、秋蟎(Trombicula alfreddugesi)、蠍屬(Vaejovis spp.)、斜背瘤節蜱(Vasates lycopersici)；唇足綱(Chilopoda)，例如：地蜈蚣屬(Geophilus spp.)、蚰蜓屬(Scutigera spp.)；彈尾綱或彈尾目(Collembola)，例如：棘跳蟲(Onychiurus armatus)；綠圓跳蟲(Sminthurus viridis)；重足綱(Diplopoda)，例如：具斑馬陸(Blaniulus guttulatus)；昆蟲綱(Insecta)，例如：蜚蠊目(Blattodea)，例如：東方蜚蠊(Blatta orientalis)、蜚蠊(Blattella asahinai)、德國蜚蠊(Blattella germanica)、馬得拉蜚蠊(Leucophaea maderae)、姬蜚蠊(Loboptera decipiens)、斑蠊(Neostylopyga rhombifolia)、古巴蜚蠊屬(Panchlora spp.)、帕科蜚蠊屬(Parcoblatta spp.)、家蠊屬(Periplaneta spp.)(例如：美洲家蠊(Periplaneta americana)、澳洲家蠊(Periplaneta australasiae))、蔗蠊(Pycnoscelus surinamensis)、長鬚帶蠊(Supella longipalpa)；鞘翅目(Coleoptera)，例如：鑲邊黃瓜甲蟲(Acalymma vittatum)、大豆象(Acanthoscelides obtectus)、麗金龜屬(Adoretus spp.)、小蜂窩甲蟲(Aethina tumida)、赤楊紫跳甲(Agelastica alni)、瘦吉丁蟲屬(Agrilus spp.)(例如：光蠟瘦吉丁蟲(Agrilus planipennis)、瘦吉丁蟲(Agrilus coxalis)、栗雙線瘦吉丁蟲(Agrilus bilineatus)、樺桐瘦吉丁蟲(Agrilus anxius))、叩頭蟲屬(Agriotes spp.)(例如：具條叩甲(Agriotes linneatus)、小麥金針蟲(Agriotes mancus))、外米擬步行蟲(Alphitobius diaperinus)、六月金龜子(Amphimallon solstitialis)、食骸蟲(Anobium punctatum)、天牛屬(Anoplophora spp.)(例如：光肩星天牛(Anoplophora glabripennis))、棉鈴象甲屬(Anthonomus spp.)(例如：苜蓿葉象甲(Anthonomus grandis))、蠹屬(Anthrenus spp.)、梨象屬(Apion spp.)、甘蔗金龜屬(Apogonia spp.)、隱食甲屬(Atomaria spp.)(例如：甜菜隱食甲 (Atomaria linearis))、小鰹節蟲屬(Attagenus spp.)、象甲(Baris caerulescens)、豆象(Bruchidius obtectus)、豆象甲屬(Bruchus spp.)(例如：豌豆象甲(Bruchus pisorum)、蠶豆象甲(Bruchus rufimanus))、金花蟲屬(Cassida spp.)、大豆葉甲(Cerotoma trifurcate)、象甲屬(Ceuthorrhynchus spp.)(例如：甘藍莢象甲(Ceutorrhynchus assimilis)、藍籽莖象甲(Ceutorrhynchus quadridens)、油菜象甲(Ceutorrhynchus rapae))、小金花蟲屬(Chaetocnema spp.)(例如：甘薯金花蟲(Chaetocnema confinis)、具齒跳甲(Chaetocnema denticulata)、玉米跳甲(Chaetocnema ectypa))、牛蒡象甲(Cleonus mendicus)、金針蟲屬(Conoderus spp.)、球莖象甲屬(Cosmopolites spp.)(例如：香蕉球莖象甲(Cosmopolites sordidus))、蠐螬(Costelytra zealandica)、叩頭蟲屬(Ctenicera spp.)、象甲屬(Curculio spp.)(例如：核桃象甲(Curculio caryae)、大栗象甲(Curculio caryatrypes)、榛子象甲(Curculio obtusus)、小栗象甲(Curculio sayi))、角胸粉扁蟲(Cryptolestes ferrugineus)、角胸扁蟲(Cryptolestes pusillus)、柳小隱喙象甲(Cryptorhynchus lapathi)、芒果象甲(Cryptorhynchus mangiferae)、莖象甲屬(Cylindrocopturus spp.)、密點細枝象甲(Cylindrocopturus adspersus)、黃杉枝象甲(Cylindrocopturus furnissi)、山松蟲屬(Dendroctonus spp.)(例如：龐德羅沙松小蠹蟲(Dendroctonus ponderosae))、皮蠹屬(Dermestes spp.)、葉甲屬(Diabrotica spp.)(例如：巴西玉米根蟲(Diabrotica balteata)、北方玉米根蟲(Diabrotica barberi)、南部玉米根蟲(Diabrotica undecimpunctata howardi)、黃瓜十一星葉甲(Diabrotica undecimpunctata undecimpunctata)、玉米根蟲(Diabrotica virgifera virgifera)、墨西哥玉米根蟲(Diabrotica virgifera zeae))、蛀螟屬(Dichocrocis spp.)、水稻鐵甲蟲(Dicladispa armigera)、阿根廷兜蟲屬(Diloboderus spp.)、芽象甲屬(Epicaerus spp.)、瓢蟲屬(Epilachna spp.)(例如：南瓜瓢蟲(Epilachna borealis)、食植瓢蟲(Epilachna varivestis))、跳甲屬(Epitrix spp.)(例如：黃瓜跳甲(Epitrix cucumeris)、茄跳甲(Epitrix fuscula)、煙草跳甲(Epitrix hirtipennis)、馬鈴薯跳甲(Epitrix subcrinita)、塊莖跳甲(Epitrix tuberis))、鑽孔蟲屬(Faustinus spp.)、麥蛛甲(Gibbium psylloides)、闊角 穀盜(Gnathocerus cornutus)、菜心螟(Hellula undalis)、白蠐螬(Heteronychus arator)、天牛屬(Heteronyx spp.)、金龜子(Hylamorpha elegans)、象天牛(Hylotrupes bajulus)、苜蓿象甲(Hypera postica)、藍綠象(Hypomeces squamosus)、小蠹屬(Hypothenemus spp.)(例如：咖啡果小蠹(Hypothenemus hampei)、蘋枝小蠹(Hypothenemus obscurus)、果小蠹(Hypothenemus pubescens))、鰓角金龜(Lachnosterna consanguinea)、煙甲蟲(Lasioderma serricorne)、長首穀盜(Latheticus oryzae)、薪甲屬(Lathridius spp.)、負泥甲屬(Lema spp.)、馬鈴薯甲蟲(Leptinotarsa decemlineata)、潛葉蛾屬(Leucoptera spp.)(例如：咖啡潛葉蛾(Leucoptera coffeella))、稻象甲(Lissorhoptrus oryzophilus)、莖象甲屬(Listronotus(=Hyperodes)spp.)、黃象甲屬(Lixus spp.)、葉甲屬(Luperodes spp.)、黃胸葉甲(Luperomorpha xanthodera)、粉蠹屬(Lyctus spp.)、縊虎天牛屬(Megacyllene spp.)(例如：刺槐縊虎天牛(Megacyllene robiniae))、美洲葉甲屬(Megascelis spp.)、叩頭蟲屬(Melanotus spp.)(例如：奧勒岡州叩甲(Melanotus longulus oregonensis))、花粉甲(Meligethes aeneus)、吹粉金龜屬(Melolontha spp.)(例如：大栗鰓角金龜(Melolontha melolontha))、天牛屬(Migdolus spp.)、天牛屬(Monochamus spp.)、象甲(Naupactus xanthographus)、郭公蟲屬(Necrobia spp.)、新螢金花蟲屬(Neogalerucella spp.)、金黃蛛甲(Niptus hololeucus)、犀角金龜(Oryctes rhinoceros)、鋸胸粉扁蟲(Oryzaephilus surinamensis)、稻象甲(Oryzaphagus oryzae)、深溝象甲屬(Otiorrhynchus spp.)(例如：蘋果白象甲(Otiorhynchus cribricollis)、苜蓿象甲(Otiorhynchus ligustici)、草莓根象甲(Otiorhynchus ovatus)、根象甲(Otiorhynchus rugosostriarus)、黑藤象甲(Otiorhynchus sulcatus))、負泥蟲屬(Oulema spp.)(例如：橙足負泥蟲(Oulema melanopus)、稻負泥蟲(Oulema oryzae))、銀點花金龜(Oxycetonia jucunda)、猿葉蟲(Phaedon cochleariae)、食葉蟲屬(Phyllophaga spp.)、鰓角金龜(Phyllophaga helleri)、葉蚤屬(Phyllotreta spp.)(例如：辣根跳甲(Phyllotreta armoraciae)、柔弱黑跳甲(Phyllotreta pusilla)、美條紋跳甲(Phyllotreta ramosa)、黃條葉蚤(Phyllotreta striolata))、日本麗金龜 (Popillia japonica)、小象甲屬(Premnotrypes spp.)、大穀蠹(Prostephanus truncatus)、跳甲屬(Psylliodes spp.)(例如：馬鈴薯跳甲(Psylliodes affinis)、油菜蘭跳甲(Psylliodes chrysocephala)、忽布跳甲(Psylliodes punctulata))、蛛甲屬(Ptinus spp.)、黑根瓢蟲(Rhizobius ventralis)、粉長蠹蟲(Rhizopertha dominica)、象鼻蟲屬(Rhynchophorus spp.)、椰子象鼻蟲(Rhynchophorus ferrugineus)、棕櫚象鼻蟲(Rhynchophorus palmarum)、小蠹屬(Scolytus spp.)(例如：歐洲大榆小蠹(Scolytus multistriatus))、雙棘長蠹蟲(Sinoxylon perforans)、米象屬(Sitophilus spp.)(例如：穀象(Sitophilus granarius)、羅望子象(Sitophilus linearis)、米象(Sitophilus oryzae)、玉米象(Sitophilus zeamais))、穀象屬(Sphenophorus spp.)、藥材甲蟲(Stegobium paniceum)、莖象屬(Sternechus spp.)(例如：豆莖象(Sternechus paludatus))、扁肩象屬(Symphyletes spp.)、象甲屬(Tanymecus spp.)(例如：玉米葉象(Tanymecus dilaticollis)、纖毛象(Tanymecus indicus)、紅豆草灰象甲(Tanymecus palliatus))、粉甲(Tenebrio molitor)、穀盜(Tenebrioides mauretanicus)、擬穀盜屬(Tribolium spp.)(例如：黑粉榖盜(Tribolium audax)、擬榖盜(Tribolium castaneum)、扁擬榖盜(Tribolium confusum))、鰹節蟲屬(Trogoderma spp.)、象甲屬(Tychius spp.)、虎天牛屬(Xylotrechus spp.)、步甲屬(Zabrus spp.)(例如：玉米步甲(Zabrus tenebrioides))；革翅目(Dermaptera)，例如：肥螋(Anisolabis maritime)、歐洲球螋(Forticula auricularia)、蠼螋(Labidura riparia)；雙翅目(Diptera)，例如：伊蚊屬(Aedes spp.)(例如：埃及斑蚊(Aedes aegypti)、白線斑蚊(Aedes albopictus)、叮刺伊蚊(Aedes sticticus)、騷擾伊蚊(Aedes vexans))、潛蠅屬(Agromyza spp.)(例如：寬額斑潛蠅(Agromyza frontella)、美洲黍潛葉蠅(Agromyza parvicornis))、按實蠅屬(Anastrepha spp.)、按蚊屬(Anopheles spp.)(例如：四斑按蚊(Anopheles quadrimaculatus)、甘比亞瘧蚊(Anopheles gambiae))、癭蚊屬(Asphondylia spp.)、實蠅屬(Bactrocera spp.)(例如：瓜實蠅(Bactrocera cucurbitae)、東方果實蠅(Bactrocera dorsalis)、橄欖果蠅(Bactrocera oleae))、毛蚊(Bibio hortulanus)、麗蠅(Calliphora erythrocephala)、紅頭麗蠅(Calliphora vicina)、 地中海果實蠅(Ceratitis capitata)、搖蚊屬(Chironomus spp.)金蠅屬(Chrysomya spp.)、斑虻屬(Chrysops spp.)、麻翅虻(Chrysozona pluvialis)、刺蚊屬(Cochliomyia spp.)、康癭蚊屬(Contarinia spp.)(例如：葡萄癭蚊(Contarinia johnsoni)、甘藍癭蚊(Contarinia nasturtii)、梨葉癭蚊(Contarinia pyrivora)、向日葵癭蚊(Contarinia schulzi)、高粱癭蚊(Contarinia sorghicola)、麥黃吸漿蟲(Contarinia tritici))、糞蠅(Cordylobia anthropophaga)、環足搖蚊(Cricotopus sylvestris)、庫蚊屬(Culex spp.)(例如：尖音庫蚊(Culex pipiens)、五帶淡色庫蚊(Culex quinquefasciatus))、庫蠓屬(Culicoides spp.)、脈毛蚊屬(Culiseta spp.)、疽蠅屬(Cuterebra spp.)、果蠅(Dacus oleae)、癭蚊屬(Dasineura spp.)(例如：油菜莢葉癭蚊(Dasineura brassicae))、地種蠅屬(Delia spp.)(例如：蔥地種蠅(Delia antiqua)、麥種蠅(Delia coarctata)、毛跗地種蠅(Delia florilega)、灰地種蠅(Delia platura)、甘藍地種蠅(Delia radicum))、人膚蠅(Dermatobia hominis)、猩猩蠅屬(Drosophila spp.)(例如：黑腹果蠅(Drosphila melanogaster)、鈴木果蠅(Drosphila suzukii))、象甲屬(Echinocnemus spp.)、芹菜尤列實蠅(Euleia heraclei)、廄蠅屬(Fannia spp.)、胃蠅屬(Gastrophilus spp.)、舌蠅屬(Glossina spp.)、麻虻屬(Haematopota spp.)、稻心蠅屬(Hydrellia spp.)、水稻潛葉蠅(Hydrellia griseola)、種蠅屬(Hylemya spp.)、虱蠅屬(Hippobosca spp.)、皮蠅屬(Hypoderma spp.)、潛蠅屬(Liriomyza spp.)(例如：白菜斑潛蠅(Liriomyza brassicae)、南美斑潛蠅(Liriomyza huidobrensis)、蔬菜斑潛蠅(Liriomyza sativae))、綠蠅屬(Lucilia spp.)(例如：絲光綠蠅(Lucilia cuprina))、羅蛉屬(Lutzomyia spp.)、沼蚊屬(Mansonia spp.)、家蠅屬(Musca spp.)(例如：家蠅(Musca domestica)、舍蠅(Musca domestica vicina))、狂蠅屬(Oestrus spp.)、瑞典蠅(Oscinella frit)、搖蚊屬(Paratanytarsus spp.)、搖蚊(Paralauterborniella subcincta)、潛蠅屬(Pegomya或Pegomyia spp.)(例如：甜菜潛蠅(Pegomya betae)、菠菜潛蠅(Pegomya hyoscyami)、懸鉤子潛蠅(Pegomya rubivora))、白蛉屬(Phlebotomus spp.)、蚤蠅屬(Phorbia spp.)、伏蠅屬(Phormia spp.)、酪蠅(Piophila casei)、蘆筍實蠅(Platyparea poeciloptera)、癭蚋屬(Prodiplosis spp.)、胡蘿蔔蠅(Psila rosae)、果實蠅屬(Rhagoletis spp.)(例如：北美櫻 桃實蠅(Rhagoletis cingulata)、核桃繞實蠅(Rhagoletis completa)、黑櫻桃實蠅(Rhagoletis fausta)、歐洲甜櫻桃繞實蠅(Rhagoletis indifferens)、藍橘繞實蠅(Rhagoletis mendax)、蘋果果實蠅(Rhagoletis pomonella))、肉蠅屬(Sarcophaga spp.)、蚋屬(Simulium spp.)(例如：南方蚋(Simulium meridionale))、螫蠅屬(Stomoxys spp.)、虻屬(Tabanus spp.)、直斑蠅屬(Tetanops spp.)、大蚊屬(Tipula spp.)(例如：歐洲大蚊(Tipula paludosa)、牧場大蚊(Tipula simplex))、彎尾托實蠅(Toxotrypana curvicauda)；半翅目(Hemiptera)，例如：金合歡昆木虱(Acizzia acaciaebaileyanae)、木虱(Acizzia dodonaeae)、木虱(Acizzia uncatoides)、長頭蝗(Acrida turrita)、無網長管蟲牙屬(Acyrthosipon spp.)(例如：碗豆蚜(Acyrthosiphon pisum))、葉蟬屬(Acrogonia spp.)、Aeneolamia屬、隆脈木虱屬(Agonoscena spp.)、蕙蘭粉虱屬(Aleurocanthus spp.)、歐洲甘藍粉虱(Aleyrodes proletella)、甘蔗穴粉虱(Aleurolobus barodensis)、棉絮粉虱(Aleurothrixus floccosus)、榴蓮被榴蓮木虱(Allocaridara malayensis)、果葉蝶屬(Amrasca spp.)(例如：二點小綠葉蟬(Amrasca bigutulla)、棉葉蟬(Amrasca devastans))、飛廉短尾蚜(Anuraphis cardui)、腎圓盾介殼蟲屬(Aonidiella spp.)(例如：橘紅腎圓盾介殼蟲(Aonidiella aurantii)、橘黃腎圓盾介殼蟲(Aonidiella citrina)、木瓜腎圓盾介殼蟲(Aonidiella inornata))、梨瘤蚜(Aphanostigma piri)、蚜蟲屬(Aphis spp.)(例如：橘捲菜蚜(Aphis citricola)、豆蚜(Aphis craccivora)、黑豆蚜(Aphis fabae)、草莓根蚜(Aphis forbesi)、大豆蚜(Aphis glycines)、棉蚜(Aphis gossypii)、常春藤蚜(Aphis hederae)、葡萄蔓蚜(Aphis illinoisensis)、蚜蟲(Aphis middletoni)、鼠李馬鈴薯蚜(Aphis nasturtii)、夾竹桃蚜(Aphis nerii)、蘋果蚜(Aphis pomi)、繡線菊蚜(Aphis spiraecola)、莢蒾蚜(Aphis viburniphila))、葡萄二星斑葉蟬(Arboridia apicalis)、木虱屬(Arytainilla spp.)、小圓盾蚧屬(Aspidiella spp.)、圓盾階屬(Aspidiotus spp.)(例如：夾竹桃圓蚧(Aspidiotus nerii))、Atanus屬、馬鈴薯蚜(Aulacorthum solani)、煙草粉虱(Bemisia tabaci)、芽木虱(Blastopsylla occidentalis)、茶樹蚜木虱(Boreioglycaspis melaleucae)、光管舌尾蚜(Brachycaudus helichrysi)、微管蟲牙屬(Brachycolus spp.)、菜蚜(Brevicoryne brassicae)、梨木虱屬 (Cacopsylla spp.)(例如：梨黃木虱(Cacopsylla pyricola))、小褐稻虱(Calligypona marginata)、絮蚧屬(Capulinia spp.)、黃頭大葉蟬(Carneocephala fulgida)、甘蔗綿蚜(Ceratovacuna lanigera)、沫蟬科(Cercopidae)、角蠟蚧屬(Ceroplastes spp.)、草莓毛管蚜(Chaetosiphon fragaefolii)、蔗黃雪盾蚧(Chionaspis tegalensis)、茶小綠葉蟬(Chlorita onukii)、臺灣大蝗(Chondracris rosea)、核桃黑斑蚜(Chromaphis juglandicola)、褐圓蚧(Chrysomphalus aonidum)、柑橘褐圓蚧(Chrysomphalus ficus)、玉米葉蟬(Cicadulina mbila)、Coccomytilus halli、蚧屬(Coccus spp.)(例如：扁堅蚧(Coccus hesperidum)、長堅蚧(Coccus longulus)、桔軟蠟蟲介(Coccus pseudomagnoliarum)、黃綠蚧(Coccus viridis))、茶藨隱瘤蚜(Cryptomyzus ribis)、Cryptoneossa屬、梳木虱屬(Ctenarytaina spp.)、黃翅葉蜂屬(Dalbulus spp.)、裸粉虱(Dialeurodes chittendeni)、柑桔裸粉虱(Dialeurodes citri)、柑桔木虱(Diaphorina citri)、盾蚧屬(Diaspis spp.)、麥蚜屬(Diuraphis spp.)、Doralis屬、草履蚧屬(Drosicha spp.)、莖蚜蟲屬(Dysaphis spp.)(例如：銹條蚜(Dysaphis apiifolia)、車前圓尾蚜(Dysaphis plantaginea)、鬱金香鱗莖蚜蟲(Dysaphis tulipae))、灰粉蚧屬(Dysmicoccus spp.)、小綠葉蟬屬(Empoasca spp.)(例如：馬鈴薯葉蟬(Empoasca abrupta)、馬鈴薯葉蟬(Empoasca fabae)、蘋果小綠葉蟬(Empoasca maligna)、茄微葉蟬(Empoasca solana)、史蒂芬氏葉蟬(Empoasca stevensi))、綿蚜屬(Eriosoma spp.)(例如：美國綿蚜(Eriosoma americanum)、蘋果綿蚜(Eriosoma lanigerum)、居梨綿蚜(Eriosoma pyricola))、斑葉蟬屬(Erythroneura spp.)、檸檬按木虱屬(Eucalyptolyma spp.)、褐木風屬(Euphyllura spp.)、鈍鼻葉蟬(Euscelis bilobatus)、拂粉蚧屬(Ferrisia spp.)、圍盾蚧屬(Fiorinia spp.)、盾蚧屬(Furcaspis oceamica)、咖啡粉蚧(Geococcus coffeae)、木虱屬(Glycaspis spp.)、銀合歡木虱(Heteropsylla cubana)、頰木虱(Heteropsylla spinulosa)、褐透翅尖頭大葉蟬(Homalodisca coagulata)、桃大尾蚜(Hyalopterus arundinis)、桃粉蚜(Hyalopterus pruni)、吹綿蚧屬(Icerya spp.)(例如：吹綿蚧(Icerya purchasi))、片角葉蟬屬(Idiocerus spp.)、綠葉蟬屬(Idioscopus spp.)、灰飛虱(Laodelphax striatellus)、球蚧屬(Lecanium spp.)(例如：李 蠟蚧(Lecanium corni)(=褐盔蠟蚧(Parthenolecanium corni))、蠣盾蚧屬(Lepidosaphes spp.)(例如：榆蠣盾蚧(Lepidosaphes ulmi))、偽菜蚜(Lipaphis erysimi)、日本長片盾蚧(Lopholeucaspis japonica)、斑衣蠟蟬(Lycorma delicatula)、長管蚜屬(Macrosiphum spp.)(例如：馬鈴薯長管蚜(Macrosiphum euphorbiae)、長管蚜(Macrosiphum lilii)、薔薇長管蚜(Macrosiphum rosae))、長針葉蟬(Macrosteles facifrons)、沫蝶屬(Mahanarva spp.)、黍蚜(Melanaphis sacchari)、Metcalfiella屬、蛾蠟蟬(Metcalfa pruinosa)、麥無網蚜(Metopolophium dirhodum)、黑緣平翅斑蚜(Monellia costalis)、胡桃黑蚜(Monelliopsis pecanis)、桃蚜屬(Myzus spp.)(例如：冬蔥瘤額蚜(Myzus ascalonicus)、李瘤蚜(Myzus cerasi)、女貞瘤額蚜(Myzus ligustri)、堇菜瘤蚜(Myzus ornatus)、桃赤蚜(Myzus persicae)、煙草蚜(Myzus nicotianae))、萵苣蚜(Nasonovia ribisnigri)、粉蝨屬(Neomaskellia spp.)、黑尾葉蟬屬(Nephotettix spp.)(例如：偽黑尾葉蟬(Nephotettix cincticeps)、黑條黑尾葉蟬(Nephotettix nigropictus))、褐飛虱(Nettigoniclla spectra)、褐飛虱(Nilaparvata lugens)、Oncometopia屬、旌蚧(Orthezia praelonga)、中華稻蝗(Oxya chinensis)、癭木虱屬(Pachypsylla spp.)、楊梅粉虱(Parabemisia myricae)、木虱屬(Paratrioza spp.)(例如：番茄木虱(Paratrioza cockerelli))、片盾蚧屬(Parlatoria spp.)、癭綿蚜屬(Pemphigus spp.)(例如：白楊癭綿蚜(Pemphigus bursarius)、多脈癭綿蚜(Pemphigus populivenae))、玉米飛虱(Peregrinus maidis)、扁角飛虱屬(Perkinsiella spp.)、粉蚧屬(Phenacoccus spp.)(例如：美地綿粉蚧(Phenacoccus madeirensis))、楊平翅棉蚜(Phloeomyzus passerinii)、瘤蚜(Phorodon humuli)、桃根蚜屬(Phylloxera spp.)(例如：核桃根瘤蚜(Phylloxera devastatrix)、警根瘤蚜(Phylloxera notabilis))、橘長盾蚧(Pinnaspis aspidistrae)、粉蚧屬(Planococcus spp.)(例如：柑桔粉蚧(Planococcus citri))、黃粉蚧(Prosopidopsylla flava)、梨形原棉蚧(Protopulvinaria pyriformis)、桑白蚧(Pseudaulacaspis pentagona)、粉蚧屬(Pseudococcus spp.)(例如：柑桔棲粉蚧(Pseudococcus calceolariae)、康氏粉蚧(Pseudococcus comstocki)、長尾粉蚧(Pseudococcus longispinus)、葡萄粉蚧(Pseudococcus maritimus)、暗色粉蚧(Pseudococcus viburni))、 Psyllopsis屬、木虱屬(Psylla spp.)(例如：黃楊木虱(Psylla buxi)、蘋木虱(Psylla mali)、梨木虱(Psylla pyri))、金小蜂屬(Pteromalus spp.)、棉蚧屬(Pulvinaria spp.)、飛虱屬(Pyrilla spp.)、圓蚧屬(Quadraspidiotus spp.)(例如：胡桃圓盾蚧(Quadraspidiotus juglansregiae)、正楊笠圓盾蚧(Quadraspidiotus ostreaeformis)、梨圓盾蚧(Quadraspidiotus perniciosus))、Quesada gigas、粉蚧屬(Rastrococcus spp.)、頸狀蚜屬(Rhopalosiphum spp.)(例如：玉米蚜(Rhopalosiphum maidis)、縊管蚜(Rhopalosiphum oxyacanthae)、稻麥蚜(Rhopalosiphum padi)、紅腹縊管蚜(Rhopalosiphum rufiabdominale))、硬蚧屬(Saissetia spp.)(例如：咖啡硬蚧(Saissetia coffeae)、硬蚧(Saissetia miranda、Saissetia neglecta)、工脊硬蚧(Saissetia oleae))、螻蛄(Scaphoides titanus)、麥二叉蚜(Schizaphis graminum)、盾蚧(Selenaspidus articulatus)、牛鞭草蚜(Sipha flava)、麥長管蚜(Sitobion avenae)、飛虱屬(Sogata spp.)、白背飛虱(Sogatella furcifera)、飛虱屬(Sogatodes spp.)、沫蟬(Stictocephala festina)、梣粉虱(Siphoninus phillyreae)、聲蚜(Tenalaphara malayensis)、Tetragonocephela屬、核桃黑蚜(Tinocallis caryaefoliae)、沫蟬屬(Tomaspis spp.)、二叉蚜屬(Toxoptera spp.)(例如：小桔蚜(Toxoptera aurantii)、大桔蚜(Toxoptera citricidus))、溫室粉虱(Trialeurodes vaporariorm)、木虱屬(Trioza spp.)(例如：棉木虱(Trioza diospyri))、紅閃小葉蟬屬(Typhlocyba spp.)、盾蚧屬(Unaspis spp.)、葡萄根瘤蚜(Viteus vitifolii)、斑點鋸蜂屬(Zygina spp.)；異翅亞目(Heteroptera)，例如：麥蝽屬(Aelia spp.)、南瓜緣蝽(Anasa tristis)、芒果蝽屬(Antestiopsis spp.)、紅緣蝽屬(Boisea spp.)、麥長蝽屬(Blissus spp.)、盲蝽屬(Calocoris spp.)、盲蝽(Campylomma livida)、二尾蚜屬(Cavelerius spp.)、臭蟲屬(Cimex spp.)(例如：臭蟲(Cimex adjunctus)、熱帶臭蟲(Cimex hemipterus)、床蝨(Cimex lectularius)、蝠臭蟲(Cimex pilosellus))、盲蝽屬(Collaria spp.)、盲蝽(Creontiades dilutus)、胡椒緣蝽(Dasynus piperis)、二葉喙蝽(Dichelops furcatus)、胡椒網蝽(Diconocoris hewetti)、蝽象屬(Dysdercus spp.)、臭蝽屬(Euschistus spp.)(例如：大豆褐蝽(Euschistus heros)、褐臭蝽(Euschistus servus)、暗淡蝽象(Euschistus tristigmus)、一點褐蝽(Euschistus variolarius))、菜蝽屬(Eurydema spp.)、 刺蝽屬(Eurygaster spp.)、褐翅蝽象(Halyomorpha halys)、夜蛾屬(Heliopeltis spp.)、稻緣蜂(Horcias nobilellus)、豬緣蝽屬(Leptocorisa spp.)、稻緣蝽象(Leptocorisa varicornis)、西方針葉樹種子甲蟲(Leptoglossus occidentalis)、葉足緣蝽(Leptoglossus phyllopus)、麗盲蝽屬(Lygocoris spp.)(例如：原麗盲蝽(Lygocoris pabulinus))、盲蝽屬(Lygus spp.)(例如：豆莢灰盲蝽(Lygus elisus)、豆莢草盲蝽(Lygus hesperus)、美國牧草盲蝽(Lygus lineolaris))、蔗黑長蝽(Macropes excavatus)、豆龜蝽(Megacopta cribraria)、盲蝽科(Miridae)、金光綠盲蝽(Monalonion atratum)、綠蝽屬(Nezara spp.)(例如：稻綠蝽象(Nezara viridula))、小長蝽屬(Nysius spp.)、盾蝽屬(Oebalus spp.)、蝽科(Pentomidae)、擬配軍蟲(Piesma quadrata)、壁蝽屬(Piezodorus spp.)(例如：紅蝽(Piezodorus guildinii))、盲蝽屬(Psallus spp.)、駱梨盲蝽象(Pseudacysta persea)、紅腹獵蝽屬(Rhodnius spp.)、可哥褐盲蝽(Sahlbergella singularis)、土蝽(Scaptocoris castanea)、稻黑蝽屬(Scotinophora spp.)、梨花網蝽(Stephanitis nashi)、臭蟲屬(Tibraca spp.)、椎蝽屬(Triatoma spp.)；膜翅目(Hymenoptera)，例如：切葉蟻(Acromyrmex spp.)、葉蜂屬(Athalia spp.)(例如：紅角菜葉蜂(Athalia rosae))、切葉蟻屬(Atta spp.)、木螞蟻屬(Camponotus spp.)、長黃胡蜂屬(Dolichovespula spp.)、松葉蜂屬(Diprion spp.)(例如：歐洲赤松葉蜂(Diprion similis))、葉蜂屬(Hoplocampa spp.)(例如：櫻實葉蜂(Hoplocampa cookei)、蘋果葉蜂(Hoplocampa testudinea))、蟻屬(Lasius spp.)、阿根廷蟻(Linepithema(Iridiomyrmex)humile)、廚蟻(Monomorium pharaonis)、黃山蟻屬(Paratrechina spp.)、黃蜂屬(Paravespula spp.)、斜結蟻屬(Plagiolepis spp.)、樹蜂屬(Sirex spp.)(例如：雲杉藍樹蜂(Sirex noctilio))、入侵紅火蟻(Solenopsis invicta)、酸臭蟻屬((Tapinoma spp.)、白足扁蟻(Teclnomyrmex albipes)、樹蜂(Urocerus spp.)、胡蜂屬(Vespa spp.)(例如：黃邊胡蜂(Vespa crabro))、小火蟻(Wasmannia auropunctata)、樹蜂屬(Xeris spp.)；等足目(Isopoda)，例如：鼠婦(Armadillidium vulgare)、海蛆(Oniscus asellus)、球鼠婦(Porcellio scaber)；等翅目(Isoptera)，例如：乳白蟻屬(Coptotermes spp.)(例如：台灣家白蟻(Coptotermes formosanus))、白蟻(Cornitermes cumulans)、堆砂白蟻屬(Cryptotermes spp.)、楹白蟻屬(Incisitermes spp.)、木白蟻屬(Kalotermes spp.)、甘蔗白蟻(Microtermes obesi)、象白蟻屬(Nasutitermes spp.)、土白蟻屬(Odontotermes spp.)、按白蟻屬(Porotermes spp.)、白蟻屬(Reticulitermes spp.)(例如：黃肢散白蟻(Reticulitermes flavipes)、西方犀白蟻(Reticulitermes hesperus))；鱗翅目(Lepidoptera)，例如：小蠟蛾(Aehroia grisella)、梁劍紋夜蛾(Acronicta major)、卷葉蛾屬(Adoxophyes spp.)(例如：棉褐帶卷蛾(Adoxophyes orana))、電紋夜蛾(Aedia leucomelas)、地老虎屬(Agrotis spp.)(例如：黃地老虎(Agrotis segetum)、小地老虎(Agrotis ipsilon))、波紋夜蛾屬(Alabama spp.)(例如：棉葉波紋夜蛾(Alabama argillacea))、蘋果蠹蛾(Amyelois transitella)、條麥蛾屬(Anarsia spp.)、夜蛾屬(Anticarsia spp.)(例如：大豆夜蛾(Anticarsia gemmatalis))、黃螟屬(Argyroploce spp.)、丫蚊夜蛾屬(Autographa spp.)、甘藍夜蛾(Barathra brassicae)、蘋髓尖蛾(Blastodacna atra)、單帶弄蝶(Borbo cinnara)、棉葉穿孔潛蛾(Bucculatrix thurberiella)、松尺蠖(Bupalus piniarius)、夜蛾屬(Busseola spp.)、卷葉蛾屬(Cacoecia spp.)、茶細蛾(Caloptilia theivora)、煙捲葉蛾(Capua reticulana)、蘋果蠹蛾(Carpocapsa pomonella)、桃蛀果蛾(Carposina niponensis)、冬尺蛾(Cheimatobia brumata)、螟屬(Chilo spp.)(例如：稻稈螟(Chilo plejadellus)、二化螟(Chilo suppressalis))、蘋果舞蛾(Choreutis pariana)、雲杉卷葉蛾屬(Choristoneura spp.)、金色雙斑蛾(Chrysodeixis chalcites)、葡萄果蠹蛾(Clysia ambiguella)、卷螟屬(Cnaphalocerus spp.)、稻縱捲葉野螟蛾(Cnaphalocrocis medinalis)、雲卷蛾屬(Cnephasia spp.)、細蛾屬(Conopomorpha spp.)、黑象甲屬(Conotrachelus spp.)、夜蛾屬(Copitarsia spp.)、小卷蛾屬(Cydia spp.)(例如：豆莢小卷蛾(Cydia nigricana)、蘋果蠹蛾(Cydia pomonella))、夜蛾(Dalaca noctuides)、野螟屬(Diaphania spp.)、螟蛉屬(Diparopsis spp.)、小蔗螟(Diatraea saccharalis)、梢斑螟屬(Dioryctria spp.)(例如：梢斑螟(Dioryctria zimmermani))、埃及金剛鑽屬(Earias spp.)、柑橘果蛾(Ecdytolopha aurantium)、南美玉米苗斑螟(Elasmopalpus lignosellus)、非洲莖螟(Eldana saccharina)、粉螟屬(Ephestia spp.)(例如：煙草粉螟(Ephestia elutella)、地中海斑螟(Ephestia kuelniella))、小卷蛾屬(Epinotia spp.)、蘋果飛蛾(Epiphyas postvittana)、尺蛾屬(Erannis spp.)、皮夜蛾(Erschoviella musculana)、螟蛾屬(Etiella spp.)、木葉蛾屬(Eudocima spp.)、巧言蟲屬(Eulia spp.)、環針單紋卷蛾(Eupoecilia ambiguella)、毒蛾屬(Euproctis spp.)(例如：棕尾毒蛾(Euproctis chrysorrhoea))、切根蟲屬(Euxoa spp.)、褐夜蛾屬(Feltia spp.)、大蠟螟(Galleria mellonella)、潛葉細蛾屬(Gracillaria spp.)、小食心蟲屬(Grapholitha spp.)(例如：桃折心蟲(Grapholita molesta)、蘋小果蠹(Grapholita prunivora))、螟蛾屬(Hedylepta spp.)、夜蛾屬(Helicoverpa spp.)(例如：番茄夜蛾(Helicoverpa armigera)、玉米夜蛾(Helicoverpa zea))、棉鈴蟲屬(Heliothis spp.)(例如：綠棉鈴蟲(Heliothis virescens))、褐織夜蛾(Hofmannophila pseudospretella)、斑螟屬(Homoeosoma spp.)、卷葉蛾屬(Homona spp.)、櫻桃巢蛾(Hyponomeuta padella)、柿食心蟲(Kakivoria flavofasciata)、灰蝶屬(Lampides spp.)、黏蟲屬(Laphygma spp.)、梨小食心蟲(Laspeyresia molesta)、茄黃斑螟(Leucinodes orbonalis)、潛葉蛾屬(Leucoptera spp.)(例如：咖啡潛葉蛾(Leucoptera coffeella))、細蛾屬(Lithocolletis spp.)(例如：斑幕潛葉蛾(Lithocolletis blancardella)、綠果夜蛾(Lithophane antennata))、卷蛾屬(Lobesia spp.)(例如：葡萄莓果飛蛾(Lobesia botrana))、豆白緣切根蟲(Loxagrotis albicosta)、毒蛾屬(Lymantria spp.)(例如：舞毒蛾(Lymantria dispar))、萊氏蛾屬(Lyonetia spp.)(例如：桃潛葉蛾(Lyonetia clerkella))、金龜(Malacosoma neustria)、豆莢螟(Maruca testulalis)、甘藍夜蛾(Mamstra brassicae)、暮眼蝶(Melanitis leda)、莖夜蛾屬(Mocis spp.)、榖蛾科(Monopis obviella)、東方黏蟲(Mythimna separate)、穀蛾(Nemapogon cloacellus)、水螟屬(Nymphula spp.)、扇頭蜱屬(Oiketicus spp.)、螟蛾屬(Omphisa spp.)、秋尺蛾屬(Operophtera spp.)、夜蛾屬(Oria spp.)、螟蛾屬(Orthaga spp.)、玉米螟屬(Ostrinia spp.)(例如：歐洲玉米螟(Ostrinia nubilalis))、小眼夜蛾(Panolis flammea)、弄蝶屬(Parnara spp.)、紅鈴蟲屬(Pectinophora spp.)(例如：棉紅鈴蟲(Pectinophora gossypiella))、潛葉蛾屬(Perileucoptera spp.)、蠹蛾屬(Phthorimaea spp.)(例如：馬鈴薯塊莖蛾(Phthorimaea operculella))、橘葉潛蛾(Phyllocnistis citrella)、細蛾屬(Phyllonorycter spp.)(例如：斑幕 潛葉(Phyllonorycter blancardella)、山楂潛葉蛾(Phyllonorycter crataegella))、粉蝶屬(Pieris spp.)(例如：紋白蝶(Pieris rapae))、荷蘭石竹小卷蛾(Platynota stultana)、印度穀斑螟(Plodia interpunctella)、擬尺蠖屬(Plusia spp.)、小菜蛾(Plutella xylostella)(=小菜蛾(Plutella maculipennis))、鑽空蟲屬(Podesia spp.)(例如：紫丁香鑽空蟲(Podesia syringae))、巢蛾屬(Prays spp.)、黏蟲屬(Prodenia spp.)、天蛾屬(Protoparce spp.)、黏蟲屬(Pseudaletia spp.)(例如：星黏蟲(Pseudaletia unipuncta))、大豆夜蛾(Pseudoplusia includens)、野螟(Pyrausta nubilalis)、薄荷灰夜蛾(Rachiplusia nu)、三化螟屬(Schoenobius spp.)(例如：三化螟(Schoenobius bipunctifer))、白禾螟蛾屬(Scirpophaga spp.)(例如：稻白螟(Scirpophaga innotata))、黃地老虎(Scotia segetum)、蛀莖夜蛾屬(Sesamia spp.)(例如：稻蛀莖夜蛾(Sesamia inferens))、卷葉蛾屬(Sparganothis spp.)、斜紋夜蛾屬(Spodoptera spp.)(例如：斜紋夜蛾(Spodoptera eradiana)、甜菜夜蛾(Spodoptera exigua)、草地斜紋夜蛾(Spodoptera fiugiperda)、灰翅夜蛾(Spodoptera praefica))、舉肢蛾屬(Stathmopoda spp.)、織蛾屬(Stenoma spp.)、潛葉蟲(Stomopteryx subsecivella)、透翅蛾屬(Synanthedon spp.)、馬鈴薯塊莖蛾(Tecia solanivora)、松舟蛾屬(Thaumetopoea spp.)、幹煞夜蛾(Thermesia gemmatalis)、軟木長角蛾(Tinea cloacella)、網衣蛾(Tinea pellionella)、袋穀蛾(Tineola bisselliella)、櫟綠卷葉蛾屬(Tortrix spp.)、毛氈衣蛾(Trichophaga tapetzella)、夜蛾屬(Trichoplusia spp.)(例如：粉紋夜蛾(Trichoplusia ni))、三化螟(Tryporyza incertulas)、番茄斑潛蠅(Tuta absoluta)、小灰蝶屬(Virachola spp.)；直翅目(Orthoptera)或跳躍亞目(Saltatoria)，例如：家蟋蟀(Acheta domesticus)、草蜢屬(Dichroplus spp.)、螻蛄屬(Gryllotalpa spp.)(例如：歐洲螻蛄(Gryllotalpa gryllotalpa))、蔗蝗屬(Hieroglyphus spp.)、飛蝗屬(Locusta spp.)(例如：東亞飛蝗(Locusta migratoria))、負蝗屬(Melanoplus spp.)(例如：赤地蚱蜢(Melanoplus devastator))、烏蘇裏擬寰螽(Paratlanticus ussuriensis)、群居蚱蜢(Schistocerca gregaria)；毛蝨目(Phthiraptera)，例如：毛蝨屬(Damalinia spp.)、豬蝨屬(Haematopinus spp.)、犬蝨屬(Linognathus spp.)、人蝨屬(Pediculus spp.)、長角羽蝨(Phylloera vastatrix)、陰蝨(Pthirus pubis)、獸 鳥蝨屬(Trichodectes spp.)；囓蟲目(Psocoptera)，例如：囓蟲屬(Lepinatus spp.)、書蝨屬(Liposcelis spp.)；蚤目(Siphonaptera)，例如：鼠蚤屬(Ceratophyllus spp.)、櫛頭蚤屬(Ctenocephalides spp.)(例如：狗櫛頭蚤(Ctenocephalides canis)、貓櫛頭蚤(Ctenocephalides felis))、人蚤(Pulex irritans)、穿皮潛蚤(Tunga penetrans)、東方鼠蚤(Xenopsylla cheopis)；纓翅目(Thysanoptera)，例如：玉米黃薊馬(Anaphothrips obscurus)、稻薊馬(Baliothrips biformis)、中斑圍孔薊馬(Chaetanaphothrips leeuweni)、葡萄德薊馬(Drepanothris reuteri)、黃帶薊馬(Enneothrips fIavens)、花薊馬屬(Frankliniella spp.)(例如：煙褐花薊馬(Frankliniella fusca)、西方花薊馬(Frankliniella occidentalis)、梳缺花薊馬(Frankliniella schultzei)、麥花薊馬(Frankliniella tritici)、越桔花薊馬(Frankliniella vaccinii)、威廉期花薊馬(Frankliniella williamsi))、正皮薊馬屬(Haplothrips spp.)、網薊馬屬(Heliothrips spp.)、溫室條籬薊馬(Hercinothrips femoralis)、卡薊馬屬(Kakothrips spp.)、葡萄薊馬(Rhipiphorothrips cruentatus)、硬薊馬屬(Scirtothrips spp.)、薊馬(Taeniothrips cardamoni)、薊馬屬(Thrips spp.)(例如：南黃薊馬(Thrips palmi)、蔥薊馬(Thrips tabaci))；纓尾目(Zygentoma)(=總尾目(Thysanura))，例如：櫛衣魚屬(Ctenolepisma spp.)、西洋衣魚(Lepisma saccharina)、盜火蟲(Lepismodes inquilinus)、斑衣魚(Thermobia domestica)；結合綱(Symphyla)，例如：蚰蜒屬(Scutigerella spp.)，例如：白松蟲(Scutigerella immaculata)；軟體動物門(Mollusca)，例如：雙殼綱(Bivalva)之害蟲，例如：飾貝屬(Dreissena spp.)；及腹足綱(Gastropoda)，例如：蛞蝓屬(Arion spp.)(例如：紅蛞蝓(Arion ater rufus))、紅扁蜷屬(Biomphalaria spp.)、泡螺屬(Bulinus spp.)、灰蛞蝓屬(Deroceras spp.)(例如：黏液蛞蝓(Deroceras leave))、土蝸螺屬(Galba spp.)、椎實螺屬(Lymnaea spp.)、釘螺屬(Oncomelania spp.)、福壽螺屬(Pomacea spp.)、琥珀螺屬(Succinea spp.)；來自線蟲動物門(Nematoda)之植物害蟲，亦即植物寄生性線蟲，特別指：墊刃線蟲屬(Aglenchus spp.)(例如：居農野外墊刃線蟲(Aglenchus agricola))、粒癭線蟲屬(Anguina spp.)(例如：小麥粒癭線蟲(Anguina tritici))、滑刃線蟲屬(Aphelenchoides spp.)(例如：花生滑刃線蟲(Aphelenchoides arachidis)、 葉芽滑刃線蟲(Aphelenchoides fragariae))、刺線蟲屬(Belonolaimus spp.)(例如：豌豆刺線蟲(Belonolaimus gracilis)、長尾刺線蟲(Belonolaimus longicaudatus)、諾頓刺線蟲(Belonolaimus nortoni))、傘滑刃線蟲屬(Bursaphelenchus spp.)(例如：椰子紅環腐線蟲(Bursaphelenchus cocophilus)、傘滑刃線蟲(Bursaphelenchus eremus)、松材線蟲(Bursaphelenchus xylophilus))、固著線蟲屬(Cacopaurus spp.)(例如：波斯固著線蟲(Cacopaurus pestis))、環紋線蟲屬(Criconemella spp.)(例如：彎曲環紋線蟲(Criconemella curvata)、環紋線蟲(Criconemella onoensis)、裝飾環紋線蟲(Criconemella ornata)、環紋線蟲(Criconemella rusium)、葡萄環紋線蟲(Criconemella xenoplax)(=環腐線蟲(Mesocriconema xenoplax))、小環線蟲屬(Criconemoides spp.)(例如：弗尼亞小環線蟲(Criconemoides ferniae)、小環線蟲(Criconemoides onoense)、杯口小環線蟲(Criconemoides ornatum))、莖囊線蟲(Ditylenchus spp.)(例如：莖線蟲(Ditylenchus dipsaci))、錐線蟲屬(Dolichodorus spp.)、包囊線蟲屬(Globodera spp.)(例如：馬鈴薯白線蟲(Globodera pallida)、黃色馬鈴薯包囊線蟲(Globodera rostochiensis))、螺旋線蟲屬(Helicotylenchus spp.)(例如：雙宮螺旋線蟲(Helicotylenchus dihystera))、半鞘線蟲屬(Hemicriconemoides spp.)、鞘線蟲屬(Hemicycliophora spp.)、異皮線蟲屬(Heterodera spp.)(例如：禾穀異皮線蟲(Heterodera avenae)、大豆異皮線蟲(Heterodera glycines)、甜菜異皮線蟲(Heterodera schachtii))、穿根線蟲屬(Hirschmaniella spp.)、紐帶線蟲屬(Hoplolaimus spp.)、長刺線蟲屬(Longidorus spp.)(例如：非洲長刺線蟲(Longidorus africanus))、根瘤線蟲屬(Meloidogyne spp.)(例如：奇特伍德根瘤線蟲(Meloidogyne chitwoodi)、法克斯根瘤線蟲(Meloidogyne fallax)、北方根瘤線蟲(Meloidogyne hapla)、南方根瘤線蟲(Meloidogyne incognita))、根瘤線蟲屬(Meloinema spp.)、假根瘤線蟲屬(Nacobbus spp.)、擬莖線蟲屬(Neotylenchus spp.)、殘根線蟲屬(ParalongidoruS spp.)、擬滑刃線蟲屬(Paraphelenchus spp.)、擬毛刺線蟲屬(Paratrichodorus spp.)(例如：微小擬毛刺線蟲(Paratrichodorus minor))、釘線蟲屬(Paratylenchus spp.)、短體線蟲屬(Pratylenchus spp.)(例如：穿 刺短體線蟲(Pratylenchus penetrans))、假海矛線蟲屬(Pseudohalenchus spp.)、平滑墊刃線蟲屬(Psilenchus spp.)、胞囊線蟲屬(Punctodera spp.)、溝線蟲屬(Quinisulcius spp.)、穿孔線蟲屬(Radopholus spp.)(例如：柑橘穿孔線蟲(Radopholus citrophilus)、香蕉穿孔線蟲(Radopholus similis))、腎狀線蟲屬(Rotylenchulus spp.)、盤旋線蟲屬(Rotylenchus spp.)、螺旋線蟲屬(Scutellonema spp.)、粒線蟲屬(Subanguina spp.)、毛刺線蟲屬(Trichodorus spp.)(例如：鈍毛刺線蟲(Trichodorus obtusus)、原始毛刺線蟲(Trichodorus primitivus))、矮化線蟲屬(Tylenchorhynchus spp.)(例如：飾環矮化線蟲(Tylenchorhynchus annulatus))、半穿刺線蟲屬(Tylenchulus spp.)(例如：柑橘半穿刺線蟲(Tylenchulus semipenetrans))、劍線蟲屬(Xiphinema spp.)(例如：標準劍線蟲(Xiphinema index))。 The compound of formula (I) is preferably used as a pesticide. They are active against normal sensitivities and resistant species, and against all or specific stages of development. The above pests include: Arthropoda, especially arachnid (Arachnida) pests, for example: Acarus spp. ) (eg: Acarus siro), Aceria kuko, Aceria sheldoni, Aculops spp. ), Acanthope (Aculus spp. ) (for example: Aculus fockeui, Aculus schlechtendali), Amblyomma spp. ), Amphitetrany sinensis (Amphitetrany sinensis), Argas spp. ), Bovineus spp. ), Red genus (Brevipalpus spp. (eg: Brevipalpus phoenicis), Bryobia graminum, Bryobia praetiosa, Centruroides spp. ), genus (Chorioptes spp. ), Dermanyssus gallinae, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermacentor spp. ), Eotetranychus spp. ) (eg: Eotetranychus hicoriae), Epipirerus pyri, Eutetranychus spp. ) (eg Eutetranychus banksi), Eriophyes spp. ) (eg Eriophyes pyri), Glycyphagus domesticus, Halotydeus destructor, Hemitarsonemus spp. (eg: Hemitarsonemus latus (= Polyphagotarsonemus latus), genus Hyalomama spp. ), hard genus (Ixodes spp. ), the genus Arachnid (Latrodectus spp. ), Loxosceles spp. ), autumn scorpion (Neutrombicula autumnalis), Nuphersa genus, genus Oligonychus spp. (eg: Oligonychus coffee, Oligonychus coniferarum, Oligonychus ilicis, Oligonychus indicus, Oligonychus mangiferus, Oligonychus pratensis, Oligonychus punicae, Oligonychus yothersi, Ornithodorus spp. ), the giant genus Robinia (Ornithonyssus spp. ), Red spider genus (Panonychus spp. ) (for example: Panonychus citri (= Metatetranychus citri), Panonychus ulmi (=Metatetranychus ulmi), Phyllocoptruta oleivora ), succulent leafhopper (Platytetranychus multidigituli), Polyphagotarsonemus latus, Psoroptes spp. ), Rhipicephalus spp. ), Rhizoglyphus spp. ), human genus (Sarcoptes spp. ), Scorpio maurus, Stenotarsonemus spp. ), Steneotarsonemus spinki, Tarsonemus spp. ) (for example: Tarsonemus confusus, Tarsonemus pallidus), Tetranychus spp. (eg: Tetranychus canadensis, Tetranychus cinnabarinus, Tetranychus turkestani, Tetranychus urticae), Trimculcula alfreddugesi, Vaejovis Spp. ), Vasates lycopersici; Chilopoda, for example: Geophilus spp. ), genus (Scutigera spp. Collembola, such as: Onychiurus armatus; Sminthurus viridis; Diplopoda, for example: Blaiulus guttulatus; Insecta (Insecta), for example: Blattodea, for example: Blatta orientalis, Blattella asahinai, Blattella germanica, Leucophaea maderae, Flycatcher Loboptera decipiens, Neostyylopyga rhombifolia, Panchlora spp. ), Pacoblatta spp. ), family genus (Periplaneta spp. (eg, Periplaneta americana, Periplaneta australasiae), Pycnoscelus surinamensis, Supella longipalpa, Coleoptera, for example: striped cucumber beetle ( Acalymma vittatum), soy elephant (Acanthoscelides obtectus), genus Aurora (Adoretus spp. ), Aethina tumida, Agelastica alni, Agrigen spp. (eg: Agrilus planipennis, Agrilus coxalis, Agrilus bilineatus, Agrilus anxius), beetle Genus (Agriotes spp. (eg: Agriotes linneatus, Agriotes mancus), Alphitobius diaperinus, Amphimallon solstitialis, Anobium punctatum, and beetle Genus (Anoplophora spp. ) (eg Anpolophora glabripennis), Anthonomus spp. ) (for example: Anthonomus grandis), Anthrenus spp. ), pear genus (Apion spp. ), Sugarcane genus (Apogonia spp. ), Atomaria spp. ) (eg: Atomaria linearis), Attagenus spp. ), Baris caerulescens, Bruchidius obtectus, Bruuchus spp. ) (for example: Bruchus pisorum, Bruchus rufimanus), Cassida spp. ), soybean leaf (Cerotoma trifurcate), genus (Ceuthorrhynchus spp. (eg: Ceutorrhynchus assimilis, Ceutorrhynchus quadridens, Ceutorrhynchus rapae), Chaetocnema spp. (eg: Chaetocnema confinis, Chaetocnema denticulata, Chaetocnema ectypa), Cleonus mendicus, Conoderus spp. ), bulbous genus (Cosmopolites spp. ) (eg: Cosmopolites sordidus), Costelytra zealandica, Ctenicera spp. ), genus Curculio spp. ) (eg: Curculio caryae, Curculio caryatrypes, Curculio obtusus, Curculio sayi), Cryptolestes ferrugineus, horn chest Cryptolestes pusillus, Cryptorhynchus lapathi, Cryptorhynchus mangiferae, Cylindrocopturus spp. ), Cylindrocopturus adspersus, Cylindrocopturus furnissi, Dendroctonus spp. ) (eg: Dendroctonus ponderosae), Dermestes spp. ), A. genus (Diabrotica spp. (eg: Diabrotica balteata, Diabrotica barberi, Diabrotica undecimpunctata howardi, Diabrotica undecimpunctata undecimpunctata, Diabrotica virgifera Virgifera), Diabrotica virgifera zeae, Dichocrocis spp. ), rice iron beetle (Dicladispa armigera), Argentine genus (Diloboderus spp. ), genus Epicaerus spp. ), Ladybug (Epilachna spp. ) (eg, Epilachna borealis, Epilachna varivestis), Epitrix spp. (eg: Epitrix cucumeris, Epitrix fuscula, Epitrix hirtipennis, Epitrix subcrinita, Epitrix tuberis), Botrytis ( Faustinus spp. ), Gibbium psylloides, Gnathocerus cornutus, Hellula undalis, Heteronychus arator, Heteronyx spp. ), Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypomeces squamosus, Hypothenemus spp. (eg: Hypothenemus hampei, Hypothenemus obscurus, Hypothenemus pubescens), Lachnosterna consanguinea, Lasioderma serricorne, Long Shougu (Latheticus oryzae), Lathridius spp. ), negative genus (Lema spp. ), potato beetle (Leptinotarsa decemlineata), Lepidoptera spp. (eg: Leucoptera coffeella), Lisorhoptrus oryzophilus, Listronotus (=Hyperodes) spp. ), the yellow genus (Lixus spp. ), Luperodes spp. ), Luperomorpha xanthodera, Lyctus spp. ), the genus Magnolia spp. ) (eg, Megacyllene robiniae), Megascelis spp. ), the genus of the genus Melanotus spp. (eg: Melanotus longulus oregonensis), Meligethes aeneus, Melonontha spp. ) (eg: Melonontha melolontha), M. genus (Migdolus spp. ), the genus of the genus Monochamus spp. ), Napactus xanthographus, Necrobia spp. ), Neogolder nectar (Neogalerucella spp. ), Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus spp. (eg: Otiorhynchus cribricollis, Otiorhynchus ligustici, Otiorhynchus ovatus, Otiorhynchus rugosostriarus, Otiorhynchus sulcatus), Negative worms (Oulema spp. (eg: Oulema melanopus, Oulema oryzae), Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp. ), Phyllophaga helleri, Phyllotreta spp. ) (eg: Phyllotreta armoraciae, Phyllotreta pusilla, Phyllotreta ramosa, Phyllotreta striolata), Popillia japonica, small Genus (Premnotrypes spp. ), Prostephanus truncatus, Psylliodes spp. ) (eg Psylliodes affinis, Psylliodes chrysocephala, Psylliodes punctulata), Ptinus spp. ), Rhizobius ventralis, Rhizopertha dominica, Rhynchophorus spp. ), Rhynchophorus ferrugineus, Rhynchophorus palmarum, Scolytus spp. ) (eg: Scolytus multistriatus), Sinoxylon perforans, Sitophilus spp. (eg: Sitophilus granarius, Sitophilus linearis, Sitophilus oryzae, Sitophilus zeamais), Sphenophorus spp. ), Stembium paniceum, Stemichus spp. ) (for example: Sternechus paludatus), Lyrics genus (Symphyletes spp. ), the genus of the genus (Tanymecus spp. (eg: Tanymecus dilaticollis, Tanymecus indicus, Tanymecus palliatus), Tenebrio molitor, Tenebrioides mauretanicus, Tribolium spp . (eg: Tribolium audax, Tribolium castaneum, Tribolium confusum), Trojanderma spp. ), the genus of the genus (Tychius spp. ), Xylotrechus spp. ), the genus of the genus (Zabrus spp. (for example: Zabrus tenebrioides); Dermaptera, for example: Anisolabis maritime, Forticula auricularia, Labidura riparia; Diptera , for example: Aedes spp. (eg: Aedes aegypti, Aedes albopictus, Aedes sticticus, Aedes vexans), Agromyza spp. ) (eg Agromyza frontella, Agromyza parvicornis), Anastrepha spp. ), Anopheles spp. (eg: Anopheles quadrimaculatus, Anopheles gambiae), Asphondylia spp. ), the fruit fly (Bactrocera spp. (eg: Bactrocera cucurbitae, Bactrocera dorsalis, Bactrocera oleae), Bibio hortulanus, Calliphora erythrocephala, Calliphora vicina , Mediterranean fruit fly (Ceratitis capitata), Chironomus spp. ) Chrysomya spp. ), genus Chrysops spp. ), Chrysozona pluvialis, Cochliomyia spp. ), Contarinia spp. (eg: Contarinia johnsoni, Contarinia nasturtii, Contarinia pyrivora, Contarinia schulzi, Contarinia sorghicola, Contarinia) Tritici)), Cordylobia anthropophaga, Cricotopus sylvestris, Culex spp. ) (eg Culex pipiens, Culex quinquefasciatus), Culicoides spp. ), Culexeta spp. ), genus genus (Cuterebra spp. ), Drosophila (Dacus oleae), Aedes (Dasineura spp. (eg: Dasineura brassicae), Delia spp. (eg, Delia antiqua, Delia coarctata, Delia florilega, Delia platura, Delia radicum), Dermatobia hominis, Drosophila spp. ) (eg Drosphila melanogaster, Drosphila suzukii), Echinocnemus spp. ), Euleia heraclei, genus Fannia spp. ), the genus of the genus Gastrophilus spp. ), Glossina spp. ), genus Haematopota spp. ), genus Hydrellia spp. ), Rice leaf miner (Hydrellia griseola), Hydrangea (Hylemya spp. ), the genus Hypobesca spp. ), the genus Hypoderma spp. ), Liriomyza spp. (eg: Liriomyza brassicae, Liriomyza huidobrensis, Liriomyza sativae), Lucilia spp. ) (eg Lucilia cuprina), Lutzomyia spp. ), the genus Mosquito (Mansonia spp. ), Musca spp. ) (eg Musca domestica, Musca domestica vicina), Oestro spp. ), Swedish fly (Oscinella frit), Chironus (Paratanytarsus spp. ), Chiarozoa (Paralauterborniella subcincta), Liriomyza (Pegomya or Pegomyia spp. (eg Pegomya betae, Pegomya hyoscyami, Pegomya rubivora), Phlebotomus spp. ), the genus Hypora (Phorbia spp. ), the genus Phormia spp. ), Piophila casei, Platyparea poeciloptera, Prodiplosis spp. ), Psila rosae, Rhagoletis spp. (eg, Rhagoletis cingulata, Rhagoletis completa, Rhagoletis fausta, Rhagoletis indifferens, Rhodoletis indifferens, Rhagoletis mendax ), Rhagoletis pomonella, Sarcophaga spp. ), genus (Simulium spp. ) (for example: Simulium meridionale), Stomoxys spp. ), genus (Tabanus spp. ), the genus Stratus (Tetanops spp. ), the genus of the genus (Tipula spp. (eg: Tipula paludosa, Tipula simplex), Toxotrypana curvicauda, Hemiptera, eg Acizzia acaciaebaileyanae, Acizzia dodonaeae, Acizzia uncatoides, Acrida turrita, Acyrthosipon spp. ) (eg: Acyrthosiphon pisum), Acrogonia spp. ), Aeneolamia genus, Aragonoscena spp. ), Aleurocanthus spp. ), Aleyrodes proletella, Aleurolobus barodensis, Aleurothrixus floccosus, Durian durian (Allocaridara malayensis), and genus Amrasca spp. (eg: Amrasca bigutulla, Amrasca devastans), Anuraphis cardui, Aonidiella spp. (eg: Aonidiella aurantii, Aonidiella citrina, Aonidiella inornata), Aphanostigma piri, Aphis (Aphis) Spp. (eg: Aphis citricola, Aphis craccivora, Aphis fabae, Aphis forbesi, Aphis glycines, Aphis gossypii, often Aphis hederae, Aphis illinoisensis, Aphis middletoni, Aphis nasturtii, Aphis nerii, Aphis pomi, Spiraea (Aphis) Spiraecola), Aphis viburniphila, Arboridia apicalis, Arytainilla spp. ), Aspidiella spp. ), the round shield genus (Aspidiotus spp. (eg: Aspidiotus nerii), Atanus genus, Aulacorthum solani, Bemisia tabaci, Blastopsylla occidentalis, Boreioglycaspis melaleucae, light tube Brachycaudus helichrysi, Brachycolus spp. ), Brasserie (Brevicoryne brassicae), Liriodendron (Cacopsylla spp. ) (eg: Cacopsylla pyricola), Calligypona marginata, Capulinia spp. ), Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp. ), Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chondracris rosea, Chromaphis juglandicola, Chrysomphalus aonidum ), Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp. (eg: Coccus hesperidum, Coccus longulus, Coccus pseudomagnoliarum, Coccus viridis), Cryptomyzus ribis, Cryptoneossa Genus, Compressed genus (Ctenarytaina spp. ), Dalbulus spp. ), Dialeurodes chittendeni, Dialeurodes citri, Diaphorina citri, Diaspis spp. ), genus Diuraphis spp. ), Doralis genus, genus Drosicha spp. ), Stem Aphid (Dysaphis spp. ) (for example: Dysaphis apiifolia, Dysaphis plantaginea, Dysaphis tulipae), Dysmicoccus spp. ), small green leaf genus (Empoasca spp. (eg: Empoasca abrupta, Emppoasca fabae, Emppoasca maligna, Emppoasca solana, Emppoasca stevensi) Genus (Eriosoma spp. (eg: Eriosoma americanum, Eriosoma lanigerum, Eriosoma pyricola), Erythroneura spp. ), lemon according to the genus Eucalyptolyma spp. ), brown wood (Euphyllura spp. ), Euscelis bilobatus, Ferrisia spp. ), the genus Fiorinia spp. ), Curcaspis oceamica, Geococcus coffeae, Glycaspis spp. ), Heteropsylla cubana, Heteropsylla spinulosa, Homalodisca coagulata, Hyalopterus arundinis, Hyalopterus pruni, blown cotton Genus (Icerya spp. ) (eg, Icerya purchasi), Idiocerus spp. ), green leaf genus (Idioscopus spp. ), Laodelphax striatellus, Lecanium spp. ) (eg Lecanium corni (Parthenolecanium corni), Lepidosaphes spp. (eg: Lepidosaphes ulmi), Lipaphis erysimi, Lopholeucaspis japonica, Lycorma delicatula, Macrosiphum spp. (eg: Macrosiphum euphorbiae, Macrosiphum lilii, Macrosiphum rosae), Macrosteles facifrons, Mahanarva spp. ), Melanaphis sacchari, Metcalfiella, Metcalfa pruinosa, Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, peach aphid Genus (Myzus spp. (eg: Myzus ascalonicus, Myzus cerasi, Myzus ligustri, Myzus ornatus, Myzus persicae, Tobacco) Myzus nicotianae), Nasonovia ribisnigri, Neomaskellia spp. ), Nephotettix spp. (eg: Nephotettix cincticeps, Nephotettix nigropictus), Nettigoniclla spectra, Nilaparvata lugens, Oncometopia genus, Orthezia praelonga ), Oxya chinensis, Pachypsylla spp. ), Parabemisia myricae, Paratrioza spp. ) (eg: Paratrioza cockerelli), Parlatoria spp. ), 瘿 蚜 (Pemphigus spp. (eg: Pemphigus bursarius, Pemphigus populivenae), Peregrinus maidis, Perkinsiella spp. ), white genus (Phenacoccus spp. (eg: Phenacoccus madeirensis), Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp. (eg: Phylloxera devastatrix, Phylloxera notabilis), Pinnaspis aspidistrae, Planococcus spp. (for example: Planococcus citri), Prosopidopsylla flava, Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp. (for example: Pseudococcus calceolariae, Pseudococcus comstocki, Pseudococcus longispinus, Pseudococcus maritimus, Pseudococcus viburni), Psyllopsis , hibiscus (Psylla spp. ) (for example: Psylla buxi, Psylla mali, Psylla pyri), Pteromalus spp. ), Aphis gossypii (Pulvinaria spp. ), spider genus (Pyrilla spp. ), Round genus (Quadraspidiotus spp. (for example: Quadraspidiotus juglansregiae, Quadraspidiotus ostreaeformis, Quadraspidiotus perniciosus), Quesada gigas, Rastrococcus spp. ), Rhopalosiphum spp. (eg: Rhopalosiphum maidis, Rhopalosiphum oxyacanthae, Rhopalosiphum padi, Rhopalosiphum rufiabdominale), Saissetia spp. (eg: Saissetia coffeae, Saissetia miranda, Saissetia neglecta, Saissetia oleae), Scaphoides titanus, Schizaphis graminum, Shield 蚧Selenaspidus articulatus), Sipha flava, Sitobion avenae, Sogata spp. ), Sogatella furcifera, Sogatodes spp. ), Stictocephala festina, Siphoninus phillyreae, Tenalaphara malayensis, Tetragonocephela, Tinocallis caryaefoliae, Tomaspis spp. ), the genus of the genus (Toxoptera spp. ) (eg: Toxoptera aurantii, Toxoptera citricidus), greenhouse whitefly (Trialeurodes vaporariorm), hibiscus (Trioza spp. ) (eg Trioza diospyri), Typhlocyba spp. ), Shield genus (Unaspis spp. ), Vineus vitifolii, Zygina spp. ); Heteroptera, for example: Aelia spp. ), Anasa tristis, Mantis genus (Antestiopsis spp. ), Red genus (Boisea spp. ), genus Blissus spp. ), genus Clolocoris spp. ), Campylomma livida, two-tailed genus (Cavelerius spp. ), bedbug (Cimex spp. (eg: Cimex adjunctus, Cimex hemipterus, Cimex lectularius, Cimex pilosellus), Collaria spp. ), Creontiades dilutus, Dasynus piperis, Dielops furcatus, Diconocoris hewetti, Dysdercus spp. ), skunk genus (Euschistus spp. (eg: Euschistus heros, Euschistus servus, Euschistus tristigmus, Euschistus variolarius), Eurydema spp. ), Hedgehog (Eurygaster spp. ), Halyomorpha halys, Heliopeltis spp. ), Horbians nobilellus, Leptocorisa spp. ), Leptocorisa varicornis, Leptoglossus occidentalis, Leptoglossus phyllopus, Lygocoris spp. ) (for example: Lygocoris pabulinus), Lygus spp. (eg: Lygus elisus, Lygus hesperus, Lygus lineolaris), Macropes excavatus, Megacopta cribraria, blind Miridae, Monalonion atratum, Nezara spp. ) (eg Nezara viridula), Nysius spp. ), Shield genus (Oebalus spp. ), Penentidae, Piesma quadrata, Piezodorus spp. ) (for example: Piezodorus guildinii), Psallus spp. ), Pearudacysta persea, Rhodonius spp. ), Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp. ), Stephanitis nashi, and Tibraca spp. ), Tricusoma spp. ); Hymenoptera, for example: Acromyrmex spp. ), Athalia spp. ) (for example: Athalia rosae), Atta spp. ), wood ant genus (Camponotus spp. ), the genus Polychaete (Dolichovespula spp. ), Dipterus spp. ) (eg: Diprion similis), Hoplocampa spp. ) (eg: Hoplocampa cookei, Hoplocampa testudinea), genus (Lasius spp. ), Argentine ants (Linepithema (Iridiomyrmex) humile), kitchen ants (Monomorium pharaonis), Yellow Mountain genus (Paratrechina spp. ), wasp genus (Paravespula spp. ), stellate genus (Plagiolepis spp. ), Tree Bee (Sirex spp. ) (eg: Sirex noctilio), invading red ant (Solenopsis invicta), acid odorant ((Tapinoma spp. ), white-footed ants (Teclnomyrmex albipes), tree bees (Urocerus spp. ), Vespa (Vespa spp. ) (for example: Vespa crabro), Wasmannia auropunctata, and Xeris spp. Isopoda, for example: Armadillidium vulgare, Oniscus asellus, Porcellio scaber; Isoptera, for example: Coptotermes spp. ) (for example: Coptotermes formosanus), termites (Cornitermes cumulans), and genus Cryptotermes spp. ), Termite genus (Incisitermes spp. ), wood termite genus (Kalotermes spp. ), sugar termites (Microtermes obesi), like termites (Nasutitermes spp. ), the termite genus (Odontotermes spp. ), according to the termite genus (Porotermes spp. ), termite genus (Reticulitermes spp. (for example: Reticulitermes flavipes, Reticulitermes hesperus); Lepidoptera, for example: Aehroia grisella, Acronicta major, leaf curl Moth (Adoxophyes spp. ) (eg: Adoxophyes orana), Aedia leucomelas, Agrotis spp. ) (eg Agrotis segetum, Agrotis ipsilon), Alabama spp. (eg: Alabama argillacea), Amyelois transitella, Anarsia spp. ), the genus Noctuidae (Anticarsia spp. ) (eg: Anticarsia gemmatalis), Astragalus spp. ), Autographa spp. ), Barathra brassicae, Blastodacna atra, Borbo cinnara, Bucculatrix thurberiella, Bupalus piniarius, Busseola Spp. ), Cacoecia spp. ), Caloptilia theivora, Capua reticulana, Carpocapsa pomonella, Carposina niponensis, Cheimatobia brumata, Chilo spp. (eg: Chilo plejadellus, Chilo suppressalis), Choreutis pariana, Choristoneura spp. ), Chrysodeixis chalcites, Clysia ambiguella, Cnaphalocerus spp. ), Cnaphalocrocis medinalis, Cnephasia spp. ), Conopomorpha spp. ), Black genus (Conotrachelus spp. ), Noctuidae (Copitarsia spp. ), Cydia spp. (eg: Cydia nigricana, Cydia pomonella), Dalaca noctuides, Diaphania spp. ), genus Diparopsis spp. ), Diatraea saccharalis, Dioryctria spp. ) (for example: Dioryctria zimmermani), Egyptian diamonds (Earias spp. ), Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldana saccharina, Ephestia spp. (eg: Ephestia elutella, Ephestia kuelniella), Epinotia spp. ), apple moth (Epiphyas postvittana), genus Erannis spp. ), Erschoviella musculana, Etiella spp. ), Eudocima spp. ), Elia spp. ), Eupoecilia ambiguella, Euproctis spp. ) (for example: Euproctis chrysorrhoea), cut genus (Euxoa spp. ), Heliothis sp. (Feltia spp. ), Galleria mellonella, Gracilla aria spp. ), the small heartworm (Grapholitha spp. ) (eg, Grapholita molesta, Grapholita prunivora), Hedylepta spp. ), Noctuidae (Helicoverpa spp. ) (eg: Helicoverpa armigera, Helicoverpa zea), Heliothis spp. ) (eg: Heliothis virescens), Hofmannophila pseudospretella, Homoeosoma spp. ), Homona spp. ), Hyponomeuta padella, Kakivoria flavofasciata, Lampides spp. ), Lacgaria spp. ), Laspeyresia molesta, Leucinodes orbonalis, Leucoptera spp. ) (eg: Leucoptera coffeella), Lithocolletis spp. ) (eg Lithocolletis blancardella, Lithohane antennata), Lobesia spp. ) (for example: Lobesia botrana), Loxaltis albicosta, Lymantria spp. ) (eg Lymantria dispar), Lyonetia spp. (eg, Lyonetia clerkella), Malacosoma neustria, Maruca testulalis, Mamstra brassicae, Melanitis leda, Mocis spp . ), Monopis obviella, Mythimna separate, Nemapogon cloacellus, Nymphula spp. ), genus Oiketicus spp. ), Ophivia spp. ), the genus Operophtera spp. ), Noctuidae (Oria spp. ), Orthaga spp. ), corn genus (Ostrinia spp. ) (eg: Ostrinia nubilalis), Panolis flammea, Parnara spp. ), red bollworm (Pectinophora spp. ) (eg, Pectinophora gossypiella), Perileucoptera spp. ), genus Phthorimaea spp. ) (eg: Phthorimaea operculella), Phylcrostis citrella, Phyllonycter spp. ) (eg: Phyllonycter blancardella, Phyllonycter crataegella), Pieris spp. ) (eg, Pieris rapae), Platynota stultana, Plodia interpunctella, Plusia spp. ), Plutella xylostella (=Plutella maculipennis), Podesia spp. ) (for example: Podesia syringae), Prays spp. ), the genus Mycobacterium (Prodenia spp. ), the genus Moth (Protoparce spp. ), genus Pseudaletia spp. (eg Pseudaletia unipuncta), Pseudoplusia includens, Pyrausta nubilalis, Rachiplusia nu, Schoenobius spp. ) (for example: Schoenobius bipunctifer), Scirpophaga spp. ) (eg: Scirpophaga innotata), Scotia segetum, Sesamia spp. ) (eg: Sesamia inferens), Sparganothis spp. ), Spodoptera spp. (eg, Spodoptera eradiana, Spodoptera exigua, Spodoptera fiugiperda, Spodoptera praefica), Stathmopoda spp. ), Stenoma spp. ), Stomopteryx subsecivella, Synanthedon spp. ), potato tuber moth (Tecia solanivora), genus Thaumetopoea spp. ), Thermesia gemmatalis, Tinea cloacella, Tinea pellionella, Tineola bisselliella, Tortrix spp. ), Trichophaga tapetzella, Trichoplusia spp. ) (eg Trichoplusia ni), Tryporyza incertulas, Tuta absoluta, Virachola spp. ); Orthoptera or Saltatoria, for example: Acheta domesticus, Dichroplus spp. ), genus (Gryllotalpa spp. ) (eg: Gryllotalpa gryllotalpa), cane genus (Hieroglyphus spp. ), genus Locusta spp. ) (eg: Locusta migratoria), Melanoplus spp. (eg, Melanoplus devastator), Paratlanticus ussuriensis, Schistocerca gregaria, Phthiraptera, for example, Damalinia spp. ), genus Haematopinus spp. ), canine genus (Linognathus spp. ), human genus (Pediculus spp. ), Phylloera vastatrix, Pthirus pubis, Trichodectes spp. ); Psocoptera, for example: Lepinatus spp. ), the book genus (Liposcelis spp. ); Siphonaptera, for example: Ceratophyllus spp. ), Ctenocephalides spp. (eg: Ctenocephalides canis, Ctenocephalides felis), Pulex irritans, Tunga penetrans, Xenopsylla cheopis, Thysanoptera (Thysanoptera), for example: Anaphothrips obscurus, Baliothrips biformis, Chaetanaphothrips leeuweni, Drepanothris reuteri, Enneothrips fIavens ), flower genus (Frankliniella spp. (eg: Frankliniella fusca, Frankliniella occidentalis, Frankliniella schultzei, Frankliniella tritici, Frankliniella vaccinii ), Frankliniella williamsi, Haplothrips spp. ), the net genus (Heliothrips spp. ), Greenhouse fence horse (Hercinothrips femoralis), Karthomas spp. ), Rhipiphorothrips cruentatus, hard hummer (Scirtothrips spp. ), eni马 (Taeniothrips cardamoni), 蓟 genus (Thrips spp. (eg: Thrips palmi, Thrips tabaci); Zygentoma (=Thysanura), for example: Ctenolepisma spp. ), Lepisma saccharina, Lepismodes inquilinus, Thermobia domestica; Symphyla, for example: Scutigerella spp. ), for example: Scutigerella immaculata; Mollusca, for example, a pest of the Bivalva, for example: Dreissena spp. ); and Gastropoda, for example: Arion spp. ) (for example: Arion ater rufus), Biomphalaria spp. ), genus Bulinus spp. ), genus genus (Deroceras spp. ) (eg: Deroceras leave), Galba spp. ), Lymnaea spp. ), Oncomelania spp. ), Pomacea spp. ), Amber snail (Succinea spp. a plant pest from the Nematoda, also known as a plant-parasitic nematode, especially: the genus Nelenchus spp. ) (eg: Aglenchus agricola), Anguina spp. ) (eg: Anguina tritici), Aphelenchoides spp. (eg: Aphelenchoides arachidis, Aphelenchoides fragariae), Nematodes (Belonolaimus spp. (eg: Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni), Bursaphelenchus spp. (eg: Bursaphelenchus cocophilus, Bursaphelenchus eremus, Bursaphelenchus xylophilus), Cacopaurus spp. ) (eg: Cacopaurus pestis), Criconemella spp. ) (eg: Criconemella curvata, Criconemella onoensis, Criconemella ornata, Criconemella rusium, Criconemella xenoplax (= ring rot) Nematode (Mesocriconema xenoplax), Creptemoides spp. ) (eg, Criconemoides ferniae, Criconemoides onoense, Criconemoides ornatum), Ditylenchus spp. ) (eg Ditylenchus dipsaci), Conlichworm (Dolichodorus spp. ), cystic nematode (Globodera spp. (eg, Globodera pallida, Globodera rostochiensis), Helicopterus spp. ) (eg: Heliconicones dihystera), Hemicriconemoides spp. ), Nematode (Hemicycliophora spp. ), Heterodera spp. (eg: Heterodera avenae, Heterodera glycines, Heterodera schachtii), Hirschmaniella spp. ), the genus Nematode (Hoplolaimus spp. ), Longidarus spp. ) (eg: Longidorus africanus), Meloidogyne spp. (eg: Meloidogyne chitwoodi, Meloidogyne fallax, Meloidogyne hapla, Meloidogyne incognita), Melolinema spp. ), pseudo-root nodule nematode (Nacobbus spp. ), Nematolinus spp. ), Residual nematode (ParalongidoruS spp. ), Paraphelenchus spp. ), Trichoderma genus (Paratrichodorus spp. ) (for example: Paratrichodorus minor), Paratylenchus spp. ), the short worm (Pratylenchus spp. ) (eg, Pratylenchus penetrans), Pseudohalenchus spp. ), smoothing edge nematode (Psilenchus spp. ), cystic genus (Punctodera spp. ), Groats (Quinisulcius spp. ), perforated nematode (Radopholus spp. ) (eg Radopholus citrophilus, Radopholus similis), Rotylenchulus spp. ), the genus Nematode (Rotylenchus spp. ), Spirulina spp. ), the genus Trianguina spp. ), Trichoderma genus (Trichodorus spp. ) (eg Trichodorus obtusus, Trichodorus primitivus), Tylenchorhynchus spp. ) (for example: Tylenchorhynchus annulatus), Tylenchulus spp. ) (eg, Tylenchulus semipenetrans), Xiphinema spp. ) (for example: the standard Xiphinema index).

式(I)化合物在某些濃度或施用率下，亦可視需要作為除草劑、安全劑、生長調節劑或改善植物性質之製劑、或作為殺微生物劑或殺配子劑使用，例如：殺真菌劑、抗黴菌劑、殺細菌劑、殺病毒劑(包括對抗類病毒之製劑)或作為對抗MLO(似黴漿菌生物體)與RLO(似立克次體生物體)之製劑。若適當時，其亦可作為合成其他活性成份之中間物或前體使用。 The compounds of formula (I) may also be used as herbicides, safeners, growth regulators or formulations for improving the properties of plants, or as microbicides or gametocides, such as fungicides, at certain concentrations or application rates. , anti-fungal agents, bactericides, viricides (including anti-viral agents) or as a formulation against MLO (mycoplasma-like organisms) and RLO (like rickettsia organisms). If appropriate, it can also be used as an intermediate or precursor for the synthesis of other active ingredients.

調配物Formulation

本發明進一步有關一種包含至少一種式(I)化合物之調配物及由其製成殺害蟲劑之施用形式，例如：灌藥、滴液及噴液。該等施用形式可視需要進一步包含其他殺害蟲劑與/或改良效用之佐劑，如：滲透劑，例如：植物油(例如：油菜籽油、葵花油)、礦物油(例如：石蠟油)、植物性脂肪酸之烷基酯類(例如：油菜籽油甲基酯或大豆油甲基酯)、或烷醇烷氧化物，與/或分佈劑，例如：烷基矽氧烷類，及/或鹽類，例如：有機或無機銨或鏻鹽類，例如：硫酸銨或磷酸氫二銨，與/或促進滯留劑，例如：磺基琥珀酸二辛酯或羥基丙基關華豆膠聚合物，與/或保濕劑，例如：甘油，與/或肥料，例如：含銨-、鉀-或磷之肥料。 The invention further relates to a formulation comprising at least one compound of the formula (I) and an application form from which the insecticide is made, for example, a drug, a drip and a spray. Such application forms may further comprise other insecticides and/or improved utilities, such as penetrants, such as vegetable oils (eg, rapeseed oil, sunflower oil), mineral oils (eg, paraffin oil), plants, as desired. Alkyl esters of fatty acids (for example: rapeseed oil methyl ester or soybean oil methyl ester), or alkanol alkoxylates, and/or distribution agents, such as alkyl oxanes, and/or salts Classes, for example: organic or inorganic ammonium or phosphonium salts, for example: ammonium sulphate or diammonium hydrogen phosphate, and/or promoting retention agents, for example: dioctyl sulfosuccinate or hydroxypropyl croton gum polymers, And/or a humectant such as glycerin, and/or a fertilizer such as a fertilizer containing ammonium, potassium or phosphorus.

常用調配物為例如：水溶性液體(SL)、乳化濃縮劑(EC)、水性乳液(EW)、懸浮濃縮劑(SC、SE、FS、OD)、水勻散性粒劑(WG)、粒劑(GR)及膠囊濃縮劑(CS)；此等及其他可能調配物型態說明於例如： FAO/WHO農藥說明聯合會議(FAO/WHO Joint Meeting on Pesticide Specifications，2004)之「Crop Life International and in Pesticide Specifications,Manual on development and use of FAO and WHO specifications for pesticides,FAO Plant Production and Protection Papers-173」，ISBN：9251048576。 Commonly used formulations are, for example, water-soluble liquid (SL), emulsified concentrate (EC), aqueous emulsion (EW), suspension concentrate (SC, SE, FS, OD), water-dispersible granules (WG), granules. Agent (GR) and capsule concentrate (CS); these and other possible formulation types are described, for example, in the FAO/WHO Joint Meeting on Pesticide Specifications (2004) "Crop Life International and In Pesticide Specifications, Manual on development and use of FAO and WHO specifications for pesticides, FAO Plant Production and Protection Papers-173", ISBN: 9251048576.

除了一或多種式(I)化合物外，調配物中尚可視需要包含其他農化活性成份。 In addition to one or more compounds of formula (I), other agrochemical active ingredients may optionally be included in the formulation.

此等較佳係包含輔劑(例如：增效劑、溶劑、自發性促進劑、載劑、乳化劑、勻散劑、霜害保護劑、殺生物劑、增稠劑與/或其他輔劑，例如：佐劑)之調配物或施用型式。本文中之佐劑係指可加強調配物生物效應，但本身沒有任何生物效應之組份。佐劑實例為促進滯留、分佈、附著葉表面或滲透之製劑。 These preferably comprise adjuvants (for example: synergists, solvents, spontaneous accelerators, carriers, emulsifiers, leveling agents, frosting protectants, biocides, thickeners and/or other adjuvants, for example : adjuvant) formulation or application pattern. As used herein, an adjuvant refers to a component that can emphasize the biological effects of the ligand but does not have any biological effects per se. Examples of adjuvants are formulations that promote retention, distribution, attachment to leaf surfaces or penetration.

此等調配物係依已知方式製備，例如：混合式(I)化合物與輔劑，例如：增效劑、溶劑與/或固態載劑與/或其他輔劑，例如：界面活性劑。調配物係於合適設備中或於施用前或施用期間製造。 These formulations are prepared in a known manner, for example, by mixing a compound of formula (I) with an adjuvant such as a synergist, a solvent and/or a solid carrier and/or other adjuvants such as a surfactant. Formulations are made in a suitable device or prior to or during administration.

所使用輔劑可為彼等對式(I)化合物之調配物或此等調配物所製成之施用型式(例如：現成可用之殺害蟲劑，如：噴灑液或拌種劑產品)賦與特殊性質，如：某些物理、技術與/或生物性質之物質。 The adjuvants used may be formulated for the formulation of the compound of formula (I) or the application form made by such formulations (for example, ready-to-use insecticidal agents, such as sprays or seed dressing products) Special properties such as certain physical, technical and/or biological properties.

合適之增效劑為例如：水、極性與非極性有機化學液體，例如：芳香族與非芳香族烴類(如：鏈烷烴、烷基苯、烷基萘、氯苯)、醇類與多元醇(若適當時，亦可經取代、醚化與/或酯化)、酮類(如：丙酮、環己酮)、酯類(包括脂肪類與油類)與(聚)醚類、未取代與經取代之胺類、醯胺類、內醯胺類(如：N-烷基吡咯啶酮)與內酯類、碸類與亞碸類(如：二甲亞碸)。 Suitable builders are, for example, water, polar and non-polar organic chemical liquids such as aromatic and non-aromatic hydrocarbons (eg, paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), alcohols and polyols. Alcohol (may be substituted, etherified and/or esterified if appropriate), ketones (eg acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, not Substituted and substituted amines, guanamines, intrinsic amines (such as N-alkylpyrrolidone) and lactones, terpenoids and anthraquinones (such as dimethyl hydrazine).

若使用水作為增效劑時，亦可使用例如：有機溶劑作為輔助溶劑。基本上適用之液態溶劑為：芳香烴(如：二甲苯、甲苯、或烷基萘類)、氯化芳香烴或氯化脂族烴類(如：氯苯、氯化乙烯或二氯甲烷)、脂族烴類(如：環己烷或鏈烷烴，例如：石油分餾物、礦物油與植物油)、醇類(如：丁醇或二醇類，及其醚類與酯類)、酮類(如：丙酮、甲基乙 基酮、甲基異丁基酮或環己酮)、強極性溶劑(如：二甲基甲醯胺與二甲亞碸)，及水。 When water is used as a synergist, for example, an organic solvent can also be used as an auxiliary solvent. Substantially applicable liquid solvents are: aromatic hydrocarbons (eg xylene, toluene, or alkylnaphthalenes), chlorinated aromatic hydrocarbons or chlorinated aliphatic hydrocarbons (eg chlorobenzene, vinyl chloride or dichloromethane) , aliphatic hydrocarbons (such as: cyclohexane or paraffins, such as: petroleum fractions, mineral oils and vegetable oils), alcohols (such as butanol or glycols, and their ethers and esters), ketones (eg acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone), strong polar solvents (eg dimethylformamide and dimethyl hydrazine), and water.

原則上可能使用所有合適溶劑。合適溶劑實例為：芳香烴類(例如：二甲苯、甲苯或烷基萘類)、氯化芳香烴或氯化脂族烴類(如：氯苯、氯化乙烯或二氯甲烷)、脂族烴類(如：環己烷、鏈烷烴、石油分餾物、礦物油與植物油)、醇類(如：甲醇、乙醇、異丙醇、丁醇或二醇類，及其醚類與酯類)、酮類(如：丙酮、甲基乙基酮、甲基異丁基酮或環已酮)、強極性溶劑(如：二甲亞碸)，及水。 It is possible in principle to use all suitable solvents. Examples of suitable solvents are: aromatic hydrocarbons (eg xylene, toluene or alkylnaphthalenes), chlorinated aromatic hydrocarbons or chlorinated aliphatic hydrocarbons (eg chlorobenzene, ethylene chloride or dichloromethane), aliphatic Hydrocarbons (eg cyclohexane, paraffins, petroleum fractions, mineral oils and vegetable oils), alcohols (eg methanol, ethanol, isopropanol, butanol or glycols, and ethers and esters thereof) , ketones (such as: acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone), strong polar solvents (such as: dimethyl hydrazine), and water.

原則上可能使用所有合適載劑。更特定言之，適用之載劑包括下列例如：銨鹽及天然礦物磨粉，如：高嶺土、礬土、滑石、白堊、石英、矽鎂土、蒙脫土或矽藻土，及合成礦物粉末，如：高分散度矽石、氧化鋁與天然或合成矽酸鹽、樹脂、蠟類與/或固體肥料。同樣可能使用此等載劑之混合物。適用於粒劑之載劑包括例如：粉碎與分碎天然礦石，如：方解石、大理石、浮石、海泡石、白雲石，及無機與有機粉末之合成顆粒，及有機材料之顆粒如：鋸屑、紙、椰子殼、玉米穗軸與菸草稈。 It is possible in principle to use all suitable carriers. More specifically, suitable carriers include, for example, ammonium salts and natural mineral milling such as kaolin, alumina, talc, chalk, quartz, strontium, montmorillonite or diatomaceous earth, and synthetic mineral powders. Such as: high dispersion vermiculite, alumina and natural or synthetic tannins, resins, waxes and / or solid fertilizers. It is also possible to use a mixture of such carriers. Carriers suitable for granules include, for example, pulverized and divided natural ores such as calcite, marble, pumice, sepiolite, dolomite, and synthetic particles of inorganic and organic powders, and particles of organic materials such as sawdust, Paper, coconut shells, corn cobs and tobacco stalks.

亦可能使用液化氣體增效劑或溶劑。特別適用之增效劑或載劑係彼等在標準溫度與常壓下呈氣態者，例如：氣霧劑推進劑，如：鹵化烴類，及丁烷、丙烷、氮氣與二氧化碳。 It is also possible to use liquefied gas synergists or solvents. Particularly suitable synergists or carriers are those which are gaseous at standard temperature and pressure, such as aerosol propellants, such as halogenated hydrocarbons, and butane, propane, nitrogen and carbon dioxide.

離子性或非離子性質乳化劑與/或泡沫形成劑、勻散劑或濕化劑、或此等表面活性物質之混合物之實例為聚丙烯酸之鹽類、木質素磺酸之鹽類、苯酚磺酸或萘磺酸之鹽類、環氧乙烷與脂肪醇類或與脂肪酸或與脂肪胺、與經取代之苯酚(較佳為烷基苯酚或芳基苯酚)之聚縮合物、磺基琥珀酸酯之鹽類、牛磺酸衍生物(較佳係牛磺酸烷基酯)、聚乙氧基化醇或苯酚之磷酸酯、多元醇之脂肪酸酯，及包含硫酸根、磺酸根與磷酸根之化合物之衍生物，例如：烷基芳基聚二醇醚類、烷基磺酸酯類、烷基硫酸酯類、芳基磺酸酯類、蛋白質水解物、木質素亞硫酸鹽廢液與甲基纖維素。若其中一種式(I)化合物與/或其中一種惰性載劑不可溶於水且當使用水施用時，宜包含界面活性劑。 Examples of ionic or nonionic emulsifiers and/or foam formers, leveling agents or wetting agents, or mixtures of such surface active materials are salts of polyacrylic acid, salts of lignosulfonic acid, phenolsulfonic acid Or a salt of naphthalenesulfonic acid, a polycondensate of ethylene oxide with a fatty alcohol or with a fatty acid or with an aliphatic amine, with a substituted phenol (preferably an alkylphenol or an arylphenol), sulfosuccinic acid a salt of an ester, a taurine derivative (preferably an alkyl taurate), a phosphate of a polyethoxylated alcohol or phenol, a fatty acid ester of a polyhydric alcohol, and a sulfate, a sulfonate and a phosphoric acid. Derivatives of the root compound, for example: alkyl aryl polyglycol ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates, protein hydrolysates, lignin sulfite waste liquids With methyl cellulose. If one of the compounds of formula (I) and/or one of the inert carriers is insoluble in water and when applied using water, it is preferred to include a surfactant.

可能存在於調配物及其所衍生之施用型式中之其他輔劑包括染劑，如：無機色素(例如：氧化鐵、氧化鈦與普魯士藍)與有機染劑(如：茜素染劑、偶氮染劑及金屬酞花青染劑)，及營養素與微量營養素，如：鐵、錳、硼、銅、鈷、鉬與鋅之鹽類。 Other adjuvants that may be present in the formulation and the application form from which it is derived include dyes such as inorganic pigments (eg, iron oxide, titanium oxide, and Prussian blue) and organic dyes (eg, alizarin dyes, even Nitrogen dyes and metal phthalocyanine dyes, and nutrients and micronutrients such as iron, manganese, boron, copper, cobalt, molybdenum and zinc.

可能存在之其他組份為安定劑，如：低溫安定劑、防腐劑、抗氧化劑、光安定劑或其他改善化學/物理安定性之製劑。亦可包含泡沫形成劑或消泡劑。 Other components that may be present are stabilizers such as low temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents that improve chemical/physical stability. A foam former or an antifoaming agent may also be included.

此外，調配物及其所衍生施用型式中亦可包含其他輔劑、膠黏劑，如：羧甲基纖維素、及天然與合成粉狀、粒狀或膠乳狀聚合物，如：阿拉伯膠、聚乙烯醇與聚乙酸乙烯酯，或天然磷脂類，如：腦磷脂與卵磷脂，及合成之磷脂類。其他可能輔劑為礦物油與植物油。若適當時，調配物及其所衍生施用型式中亦可能包含其他輔劑。此等添加劑實例為香料、保護性膠體、結合劑、黏著劑、增稠劑、搖變劑、滲透劑、促進滯留劑、安定劑、螯合劑、錯化劑、保濕劑、分佈劑。通常，式(I)化合物可與任何常用於調配目的之固態或液態添加劑組合使用。 In addition, the formulation and the application form derived therefrom may also contain other adjuvants, adhesives such as carboxymethyl cellulose, and natural and synthetic powder, granule or latex polymers, such as: gum arabic, Polyvinyl alcohol and polyvinyl acetate, or natural phospholipids, such as: cephalin and lecithin, and synthetic phospholipids. Other possible adjuvants are mineral oils and vegetable oils. If appropriate, other adjuvants may also be included in the formulation and the mode of application from which it is derived. Examples of such additives are perfumes, protective colloids, binders, adhesives, thickeners, shakers, penetrants, retention retention agents, stabilizers, chelating agents, error agents, humectants, and distribution agents. In general, the compounds of formula (I) can be used in combination with any solid or liquid additive commonly used for formulation purposes.

適用之促進滯留劑包括所有彼等降低動力表面張力之物質，例如：磺基琥珀酸二辛酯，或提高黏彈性之物質，例如：羥基丙基關華豆膠聚合物。 Suitable promoting retention agents include all materials which reduce the dynamic surface tension, such as dioctyl sulfosuccinate, or substances which increase viscoelastic properties, such as hydroxypropyl croton gum polymers.

本文之合適滲透劑包括所有彼等常用於改善農化活性成份進入植物中之滲透性之所有物質。本文中，滲透劑之定義為其從(通常為水性)施用液體及/或從噴液覆層滲透進入植物表皮層並藉以提高活性成份在表皮中移動性之能力。可採用文獻中說明之方法(Baur等人之1997,Pesticide Science 51,131-152)來測定此性質。其實例包括醇烷氧化物(如：椰子脂肪基乙氧化物(10)或異十三碳烷基乙氧化物(12))、脂肪酸酯類(例如：油菜籽油甲酯或大豆油甲酯)、脂肪胺烷氧化物(例如：獸脂胺乙氧化物(15))、或銨與/或鏻鹽類，例如：硫酸銨或磷酸氫二銨。 Suitable penetrants herein include all materials which are commonly used to improve the penetration of agrochemical active ingredients into plants. As used herein, a penetrant is defined as the ability to apply a liquid from (usually aqueous) and/or from a spray coating into the plant skin layer and thereby enhance the mobility of the active ingredient in the epidermis. This property can be determined by the method described in the literature (Baur et al. 1997, Pesticide Science 51, 131-152). Examples thereof include alcohol alkoxides (e.g., coconut fatty ethoxylate (10) or isotridecyl ethoxylate (12)), fatty acid esters (e.g., rapeseed oil methyl ester or soybean oil methyl ester) a fatty amine alkoxide (for example: tallow amine ethoxylate (15)), or an ammonium and/or phosphonium salt, for example ammonium sulphate or diammonium hydrogen phosphate.

調配物較佳係包含佔調配物重量0.00000001%至98%重量比之間之式(I)化合物，更佳係0.01%至95%重量比之式(I)化合物，最佳係0.5%至90%重量比之式(I)化合物。 Preferably, the formulation comprises a compound of formula (I), preferably from 0.01% to 95% by weight, based on the weight of the formulation, of the compound of formula (I), preferably from 0.5% to 90% by weight. % by weight of the compound of formula (I).

由調配物(特定言之殺害蟲劑)製成之施用型式中之式(I)化合物含量可在很大範圍內變化。施用型式中之式(I)化合物濃度通常佔該施用形式重量之0.00000001%至95%重量比，較佳在0.00001%至1%重量比。依適合此等施用型式之常用方式達成此應用。 The content of the compound of the formula (I) in the application form made from the formulation (specifically, a pesticidal agent) can vary over a wide range. The concentration of the compound of the formula (I) in the application form is usually from 0.00000001% to 95% by weight, preferably from 0.00001% to 1% by weight, based on the weight of the application form. This application is achieved in the usual manner suitable for such application patterns.

混合物mixture

式(I)化合物亦可與一種或多種合適之殺真菌劑、殺細菌劑、殺蜱蟎劑、殺軟體動物劑、殺線蟲劑、殺昆蟲劑、殺微生物劑、有利生物體、除草劑、肥料、驅鳥劑、強化植物劑、不孕劑、安全劑、化學傳訊物質及/或植物生長調節劑形成混合物使用，藉以例如：擴大作用範圍、延長作用效期、提高作用速率、防止排斥或預防發展出抗性。此外，這種活性成份組合可以改善植物生長及/或對非生物性因子之耐受性，例如：對高溫或低溫、對乾旱或對上升之水份或土壤鹽份含量之耐受性。亦可改善開花與結果性能、優化發芽能力與根部發展、促進收成及改善產量、影響成熟、改善所收成產物之品質與/或營養價值、為所收成產物延長儲存壽命及/或改善可加工性。 The compound of formula (I) may also be combined with one or more suitable fungicides, bactericides, acaricides, molluscicides, nematicides, insecticides, microbicides, advantageous organisms, herbicides, Use of a mixture of fertilizers, bird repellents, fortified botanicals, infertility agents, safeners, chemical signaling substances and/or plant growth regulators, for example, to broaden the range of action, extend the duration of action, increase the rate of action, prevent rejection or Prevent the development of resistance. In addition, this combination of active ingredients can improve plant growth and/or tolerance to abiotic factors such as high temperature or low temperature, tolerance to drought or increased moisture or soil salt content. It can also improve flowering and performance, optimize germination and root development, promote harvest and improve yield, affect maturity, improve the quality and/or nutritional value of harvested products, extend shelf life for harvested products and/or improve processability .

此外，式(I)化合物可與其他活性成份或化學傳訊物質(如：引誘劑與/或驅鳥劑與/或植物活化劑與/或生長調節劑與/或肥料)形成混合物。同樣地，式(I)化合物可用於改善植物性質(例如：生長、產量、及所收成材料之品質)。 Furthermore, the compounds of formula (I) may be admixed with other active ingredients or chemical signaling substances such as attractants and/or bird repellents and/or plant activators and/or growth regulators and/or fertilizers. Likewise, the compounds of formula (I) can be used to improve plant properties (eg, growth, yield, and quality of the harvested material).

根據本發明特定具體實施例中，式(I)化合物係與其他化合物，較佳係與下文說明之彼等化合物形成混合物而呈調配物型式或由該調配物製成之施用型式。 According to a particular embodiment of the invention, the compound of formula (I) is formed into a mixture with other compounds, preferably with the compounds described below, in the form of a formulation or an application form made from the formulation.

若下文述及之其中一種化合物可出現不同互變異構型，即使沒有個別出示，此等型式亦均包括在內。所有述及之混合組份亦可能依據其官能基，可能與合適鹼類或酸類形成鹽類。 If one of the compounds described below may exhibit different tautomeric forms, these forms are included even if not individually presented. All of the mixed components mentioned may also form salts with suitable bases or acids depending on their functional groups.

殺昆蟲劑/殺蜱蟎劑/殺線蟲劑Insecticide / acaricide / nematicide

本文中以其俗名稱呼之活性成份為已知者且說明於例如：「The Pesticide Manual」，第16版，British Crop Protection Council 2012或可搜尋網際網路(例如：http：//www.alanwood.net/pesticides)。該分類法 係依據本申請案提出申請當時所適用之「IRAC作用模式分類圖(IRAC Mode of Action Classification Scheme)」。 The active ingredients in this document are known by the common name and are described, for example, in "The Pesticide Manual", 16th edition, British Crop Protection Council 2012 or searchable internet (eg http://www.alanwood. Net/pesticides). The classification method is based on the "IRAC Mode of Action Classification Scheme" applied at the time of the application.

(1)乙醯基膽鹼酯酶(AChE)抑制劑，例如：胺甲酸酯類，例如：安利卡(alanycarb)、得滅克(aldicarb)、本得卡(bendiocarb)、本伏卡(benfuracarb)、布卡辛(butocarboxim)、丁氧布卡辛(buthoxycarboxim)、加保利(carbaryl)、加保扶(carbofuran)、丁基加保扶(carbosulfan)、抑芬卡(ethiofencarb)、芬布卡(fenobucarb)、覆滅蟎(formetanate)、伏賽卡(furathiocarb)、滅必蝨(isoprocarb)、滅賜克(methiocarb)、納乃得(methomyl)、滅特卡(metolcarb)、歐殺滅(oxamyl)、比加普(pirimicarb)、安丹(propoxur)、硫敵克(thiodicarb)、硫芬斯(thiofanox)、三辛滅(triazamate)、三滅卡(trimethacarb)、XMC與滅爾蝨(xylylcarb)；或有機磷酸酯類，例如：歐殺松(acephate)、亞滅伏(azamethiphos)、穀速松(azinphos)-乙基、穀速松(azinphos)-甲基、卡速松(cadusafos)、氯乙松(chlorethoxyfos)、氯芬松(chlorfenvinphos)、氯滅松(chlormephos)、陶斯松(chlorpyrifos)-甲基、庫伏斯(coumaphos)、氰乃松(cyanophos)、滅賜松(demeton)-S-甲基、大利松(diazinon)、二氯松(dichlorvos)/DDVP、雙特松(dicrotophos)、大滅松(dimethoate)、大芬松(dimethylvinphos)、二硫松(disulfoton)、EPN、愛殺松(ethion)、普伏松(ethoprophos)、胺磺磷(famphur)、芬滅松(fenamiphos)、撲滅松(fenitrothion)、芬殺松(fenthion)、福賽特(fosthiazate)、飛達松(heptenophos)、抑滅伏(imicyafos)、抑伏松(isofenphos)、O-(甲氧基胺基硫代磷醯基)水楊酸異丙基酯、抑殺松(isoxathion)、馬拉松(malathion)、滅加松(mecarbam)、達馬松(methamidophos)、滅大松(methidathion)、美文松(mevinphos)、亞素靈(monocrotophos)、乃立松(naled)、歐滅松(omethoate)、歐滅賜松(oxydemeton)-甲基、巴拉松(parathion)-甲基、賽達松(phenthoate)、福瑞松(phorate)、裕必松(phosalone)、益滅松(phosmet)、福賜米松(phosphamidon)、辛硫磷(phoxim)、亞特松(pirimiphos)-甲基、佈飛松(profenofos)、普丹松(propetamphos)、普硫松(prothiofos)、必伏松(pyraclofos)、必芬松(pyridaphenthion)、拜裕松(quinalphos)、速伏特(sulfotep)、特必松(tebupirimfos)、亞培松(temephos)、託福松(terbufos)、 四氯松(tetrachlorvinphos)、硫滅松(thiometon)、三落松(triazophos)、三氯松(triclorfon)與繁米松(vamidothion)。 (1) Acetylcholinesterase (AChE) inhibitors, for example, carbamates, for example: alanycarb, aldicarb, bendiocarb, benfuracarb ), butocarboxim, buthoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenbuca (fenobucarb), formetanate, furathiocarb, isoprocarb, metiocarb, methomyl, metolcarb, oxamyl ), pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC and xylylcarb Or organic phosphates, for example: acephate, azamethiphos, azinphos-ethyl, azinphos-methyl, cadusafos , chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos-methyl, coumaphos, cyanamide (cyanophos), demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos ), disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion ), fosthiazate, heptenophos, imicyafos, isofenphos, O-(methoxyamine thiophosphonium) isopropyl salicylate Ester, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, narcissus Naled), omethoate, oxydemeton-methyl, parathion-methyl, phenthoate, phorate, phosalone , phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, Prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, tofufos ), tetrachlorvinphos, thiometon, triazophos, triclofen and vamidothion.

(2)GABA-閘控之氯離子通道阻斷劑，例如：環二烯-有機氯，例如：克丹(chlordane)與安殺番(endosulfan)；或苯基吡唑類(飛普洛類(Fiprole))，例如：抑普洛(ethiprole)與芬普尼(fipronil)。 (2) GABA-Gate-controlled chloride channel blockers, such as cyclodiene-organochlorines, such as: chlordane and endosulfan; or phenylpyrazoles (feipulo) (Fiprole)), for example: ethiprole and fipronil.

(3)鈉通道調控劑，例如：擬除蟲菊酯類，例如：阿納寧(acrinathrin)、丙烯菊酯(allethrin)、d-順式-反式丙烯菊酯(allethrin)、d-反式丙烯菊酯(allethrin)、畢芬寧(bifenthrin)、右亞列寧(bioallethrin)、右亞列寧(bioallethrin)S-環戊烯基異構物、必賽靈(bioresmethrin)、乙氰菊酯(cyc1oprothrin)、賽扶寧(cyfluthrin)、β-賽扶寧(cyfluthrin)、賽洛寧(cyhalothrin)、λ-賽洛寧(cyhalothrin)、γ-賽洛寧(cyhalothrin)、賽滅寧(cypermethrin)、α-賽滅寧(cypermethrin)、β-賽滅寧(cypermethrin)、θ-賽滅寧(cypermethrin)、ζ-賽滅寧(cypermethrin)、賽芬寧(cyphenothrin)[(1R)-反式異構物]、第滅寧(deltamethrin)、依普靈(empenthrin)[(EZ)-(1R)異構物]、益化利(esfenvalerate)、依芬寧(etofenprox)、芬普寧(fenpropathrin)、芬化利(fenvalerate)、福本賽寧(flucythrinate)、伏滅寧(flumethrin)、τ-福化利(fluvalinate)、海本斯(halfenprox)、益普靈(imiprothrin)、剋特寧(kadethrin)、滅伏靈(momfluorothrin)、百滅寧(permethrin)、芬特寧(phenothrin)[(1R)-反式異構物]、普烈靈(prallethrin)、除蟲菊酯(pyrethrins(pyrethrum))、利滅靈(resmethrin)、希拉芬(silafluofen)、特伏靈(tefluthrin)、特滅靈(tetramethrin)、特滅靈(tetramethrin)[(1R)異構物)]、泰滅寧(tralomethrin)與參伏靈(transfluthrin)；或DDT；或美克氯(methoxychlor)。 (3) Sodium channel modulators, for example: pyrethroids, for example: acrinathrin, allethrin, d-cis-trans methrin (allethrin), d-trans Allethrin, bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer, bioresmethrin, cyc1oprothrin, Cyfluthrin, cyfluthrin, cyhalothrin, cyhalothrin, cyhalothrin, cypermethrin, α- Cypermethrin, cypermethrin, cypermethrin, cypermethrin, cyphenothrin [(1R)-trans isomer ], deltamethrin, emtemphrin [(EZ)-(1R) isomer], esfenvalerate, etofenprox, fenpropathrin, fentanyl Fenvalerate, flucythrinate, flumethrin, τ-fuvalinate, halfenprox, imiprothrin, kadethrin, Momfluorothrin, permethrin, phenothrin [(1R)-trans isomer], prallethrin, pyrethrins (pyrethrum), Resmethrin, silafluofen, tefluthrin, tetramethrin, tetramethrin [(1R) isomer), tralomethrin and Transfluthrin; or DDT; or methoxychlor.

(4)菸鹼激導性乙醯基膽鹼受體(nAChR)競爭性調控劑，例如：類新菸鹼類，例如：乙醯普(acetamiprid)、克利定(clothianidin)、第諾芬(dinotefuran)、益達胺(imidacloprid)、尼普爛(nitenpyram)、硫克比(thiacloprid)與賽速安(thiamethoxam)；或尼古丁或碸蟲啶(sulfoxaflor)或伏達隆(flupyradifurone)。 (4) Nicotine-induced acetylcholine receptor (nAChR) competitive regulators, such as neonicotinoids, such as acetamiprid, clothianidin, and dinofenol ( Dinotefuran), imidacloprid, nitenpyram, thiacloprid and thiamethoxam; or nicotine or sulfoxaflor or flupyradifurone.

(5)菸鹼激導性乙醯基膽鹼受體(nAChR)異位性調控劑，例如：賜諾殺類(Spinosyns)，例如：賜諾特(spinetoram)與賜諾殺(spinosad)。 (5) Nicotine-induced acetylcholine receptor (nAChR) atopic modulators, such as spinosyns, such as spinetoram and spinosad.

(6)麩胺酸閘控氯離子通道(GluCl)異位性調控劑，例如：抑滅克定類(avermectins)/美保黴素(milbemycin)，例如：艾滅克定(abamectin)、抑滅克定(emamectin)苯甲酸鹽、利滅克定(lepimectin)與美保克定(milbemectin)。 (6) GluCl agglutination channel (GluCl) atopic modulator, for example: avermectins / milbemycin, for example: abamectin, inhibition Emamectin benzoate, lepimectin and milbemectin.

(7)幼保激素擬似物，例如：幼保激素類似物，例如：赫普靈(hydroprene)、克普靈(kinoprene)與滅普靈(methoprene)；或吩克卡(fenoxycarb)；或必普芬(pyriproxyfen)。 (7) a juvenile hormone mimetic, such as a juvenile hormone analog, such as: hydroprene, kinoprene and metoprene; or fenoxycarb; Pypriroxyfen.

(8)其他非專一性(多重位點)抑制劑，例如：烷基鹵化物，例如：甲基溴及其他烷基鹵化物；或氯吡靈(chloropicrin)；或硫醯氟；或硼砂；或酒石酸銻鉀鹽；或異氰酸甲酯發生劑，例如：棉隆(diazomet)與威百畝(metam)。 (8) other non-specific (multiple site) inhibitors, such as: alkyl halides, such as: methyl bromide and other alkyl halides; or chloropicrin; or thiopurine; or borax; Or potassium barium tartrate; or methyl isocyanate generators, such as: diazomet and metam.

(9)弦音感覺器官調控劑，例如：必滅辛(pymetrozine)或伏卡滅(flonicamid)。 (9) A string sound sensory organ modulator, for example, pymetrozine or flonicamid.

(10)蟎生長抑制劑，例如：克芬辛(clofentezine)、海賽唑(hexythiazox)與地伏辛(diflovidazin)或抑特唑(etoxazole)。 (10) Indole growth inhibitors, for example: clofentezine, hexythiazox and diflovidazin or etoxazole.

(11)昆蟲中腸膜之微生物瓦解劑，例如：蘇雲金芽胞桿菌以色列亞種(Bacillus thuringiensis subspecies israelensis)、球形芽孢桿菌(Bacillus sphaericus)、蘇雲金芽胞桿菌鮎澤亞種(Bacillus thuringiensis subspecies aizawai)、蘇雲金芽胞桿菌庫斯塔基亞種(Bacillus thuringiensis subspecies kurstaki)、蘇雲金芽胞桿菌殺蟲亞種(Bacillus thuringiensis subspecies tenebrionis)與B.t.植物蛋白質：Cry1Ab、Cry1Ac、Cry1Fa、Cry1A.105、Cry2Ab、VIP3A、mCry3A、Cry3Ab、Cry3Bb、Cry34Ab1/35Ab1。 (11) Microbial resolving agents for insect midgut, such as Bacillus thuringiensis subspecies israelensis , Bacillus sphaericus , Bacillus thuringiensis subspecies aizawai , Suyun golden spores Bacillus thuringiensis subspecies kurstaki , Bacillus thuringiensis subspecies tenebrionis and Bt plant proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry1A.105, Cry2Ab, VIP3A, mCry3A, Cry3Ab, Cry3Bb, Cry34Ab1/35Ab1.

(12)粒線體ATP合成酶抑制劑，如：ATP瓦解劑，例如：地芬能(diafenthiuron)；或有機錫化合物，例如：亞賽錫(azocyclotin)、賽赫錫(cyhexatin)與芬塔錫(fenbutatin)氧化物；或歐蟎多(propargite)或特達芬(tetradifon)。 (12) mitochondrial ATP synthase inhibitors, such as: ATP decomposers, such as: diafenthiuron; or organotin compounds, such as: azocyclotin, cyhexatin, and fenta Tin (fenbutatin) oxide; or propargite or tetradifon.

(13)破壞質子梯度之氧化性磷酸化反應去偶合劑，例如：克芬吡(chlorfenapyr)、DNOC與氟蟲胺(sulfluramid)。 (13) An oxidative phosphorylation decoupling agent that destroys a proton gradient, such as chlorfenapyr, DNOC, and sulfluramid.

(14)菸鹼激導性乙醯基膽鹼受體通道阻斷劑，例如：本速達(bensultap)、培丹(cartap)鹽酸鹽、硫克蘭(thiocylam)與硫速伏(thiosultap)-蚋。 (14) Nicotine-induced acetylcholine receptor channel blockers, such as: bensultap, cartap hydrochloride, thiocylam, and thiosultap - Hey.

(15)幾丁質生合成抑制劑，第0型，例如：必賽伏(bistrifluron)、克伏能(chlofluazuron)、地伏能(diflubenzuron)、福環脲(flucycloxuron)、氟芬隆(flufenoxuron)、赫姆能(hexaflumuron)、利芬能(lufenuron)、利化能(novaluron)、諾化能(noviflumuron)、特速能(teflubenzuron)與三伏能(triflumuron)。 (15) Chitin biosynthesis inhibitors, type 0, for example: bistrifluron, chlofluazuron, diflubenzuron, flucycloxuron, flufenoxuron, Hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron and triflumuron.

(16)幾丁質生合成抑制劑，第1型，例如：佈芬辛(buprofezin)。 (16) Chitin biosynthesis inhibitor, type 1, for example, buprofezin.

(17)蛻變瓦解劑(尤指雙翅目)，例如：賽麻辛(cyromazine)。 (17) Metamorphic disintegrating agents (especially diptera), for example: cyromazine.

(18)脫皮激素受體促效劑，例如：可芬諾(chromafenozide)、赫芬賽(halofenozide)、甲氧芬賽(methoxyfenozide)與特芬賽(tebufenozide)。 (18) Opioid receptor agonists, for example, chromafenozide, hafenfenzide, methoxyfenozide, and tebufenozide.

(19)章魚胺受體促效劑，例如：三亞蟎(amitraz)。 (19) Octopamine receptor agonist, for example: amitraz.

(20)粒線體複合物-III電子轉運抑制劑，例如：海滅能(hydramethylnone)或亞克希(acequinocyl)或伏克靈(fluacrypyrim)。 (20) A mitochondrial complex-III electron transport inhibitor, for example, hydramethylnone or acequinocyl or fluacrypyrim.

(21)粒線體複合物-I電子轉運抑制劑，例如：METI殺蜱蟎劑，例如：芬殺蟎(fenazaquin)、芬普蟎(fenpyroximate)、普靈芬(pyrimidifen)、畢達本(pyridaben)、達芬必(tebufenpyrad)與特芬必(tolfenpyrad)；或魚藤精(rotenone)(Derris)。 (21) mitochondrial complex-I electron transport inhibitors, for example: METI acaricides, for example: fenazaquin, fenpyroximate, pyrimidifen, pirben Pyridaben), tebufenpyrad and tolfenpyrad; or rotenone (Derris).

(22)依賴電壓之鈉通道阻斷劑，例如：因得克(indoxacarb)或滅伏美松(metaflumizone)。 (22) Voltage-dependent sodium channel blockers, such as indoxacarb or metaflumizone.

(23)乙醯基-CoA羧酸酶之抑制劑，例如：季酮酸與吡咯酮酸衍生物，例如：螺克芬(spirodiclofen)、螺滅芬(spiromesifen)與賜派滅(spirotetramat)。 (23) Inhibitors of the ethenyl-CoA carboxylase, for example, quetia acid and pyrrolidone derivatives, for example, spirodiclofen, spiromesifen, and spirotetramat.

(24)粒線體複合物-IV電子轉運抑制劑，例如：膦類，例如：磷化鋁、磷化鈣、膦與磷化鋅；或氰化物、氰化鈣、氰化鉀、與氰化鈉。 (24) mitochondrial complex-IV electron transport inhibitors, such as phosphines, such as: aluminum phosphide, calcium phosphide, phosphine and zinc phosphide; or cyanide, calcium cyanide, potassium cyanide, and cyanide Sodium.

(25)粒線體複合物-II電子轉運抑制劑，例如：β-酮基腈衍生物，例如：氰必吩(cyenopyrafen)與賽芬蟎(cyflumetofen)，與羧基替苯胺類，例如：必伏拜(pyflubumide)。 (25) a mitochondrial complex-II electron transport inhibitor, for example, a β-keto nitrile derivative, for example, cyenopyrafen and cyflumetofen, and a carboxyaniline such as: Pyflubumide.

(28)蘭尼鹼(ryanodine)受體調控劑，例如：二醯胺類，例如：氯蒽吡咯(chlorantraniliprole)、氰蟲醯胺(cyantraniliprole)與表氟蟲胺(flubendiamide)，其他活性成份，例如：艾特本(afidopyropen)、艾伏樂(afoxolaner)、查得定(azadirachtin)、苯克賽(benclothiaz)、苯賽滅(benzoximate)、必芬賽(bifenazate)、布伏利(broflanilide)、新殺蟎(bromopropylate)、蟎離丹(chinomethionat)、氯丙炔菊酯(chloroprallethrin)、克利得(cryolite)、環溴蟲醯胺(cyclaniliprole)、環氧蟲啶(cycloxaprid)、氯氟氰蟲醯胺(cyhalodiamide)、二氯滅(dicloromezotiaz)、大克蟎(dicofol)、ε-美特寧(metofluthrin)、ε-滅伏靈(momfluthrin)、氟喹啉(flometoquin)、氟吲哚辛(fluazaindolizine)、氟速吩(fluensulfone)、伏吩靈(flufenerim)、氟菌蟎酯(flufenoxystrobin)、丁烯氟蟲腈(flufiprole)、氟赫吩(fluhexafon)、氟吡菌醯胺(fluopyram)、氟樂(fluralaner)、氟賽醯胺(fluxametamide)、呋喃蟲醯肼(fufenozide)、戊吡蟲胍(guadipyr)、氯氟醚菊酯(heptafluthrin)、氯噻啉(imidaclothiz)、依普同(iprodione)、κ-畢芬寧(kappa bifenthrin)、κ-特芬寧(kappa tefluthrin)、樂地蘭(lotilaner)、氯氟醚菊酯(meperfluthrin)、哌蟲啶(paichongding)、吡啶蟲丙醚(pyridalyl)、必伏松(pyrifluquinazon)、嘧蟎胺(pyriminostrobin)、賜派芬(spirobudiclofen)、四氟醚菊酯(tetramethylfluthrin)、氟氰蟲醯胺(tetraniliprole)、四氯剋安勃(tetrachlorantraniliprole)、塔賽吩(tioxazafen)、硫氟賜滅(thiofluoximate)、三氟普靈(triflumezopyrim)、與碘甲烷；及其他基於堅強芽孢桿菌(Bacillus firmus)之製劑(I-1582,BioNeem,Votivo)，與下列化合物：1-{2-氟-4-甲基-5-[(2,2,2-三氟乙基)亞磺醯基]苯基}-3-(三氟甲基)-1H-1,2,4-三唑-5-胺(來自WO2006/043635)(CAS 885026-50-6)、{1'-[(2E)-3-(4-氯苯基)丙-2-烯-1-基]-5-氟螺[吲哚-3,4'-哌啶]-1(2H)-基}(2-氯吡啶-4-基)甲酮(來自WO2003/106457)(CAS 637360-23-7)、2-氯-N-[2-{1-[(2E)-3-(4-氯苯基)丙-2-烯-1-基]哌啶-4-基}-4-(三氟甲基)苯基]異菸醯胺(來自WO2006/003494)(CAS 872999-66-1)、3-(4-氯-2,6-二甲基苯基)-4-羥基-8-甲氧基-1,8-二氮雜螺[4.5]癸-3-烯-2-酮(來自WO 2010052161)(CAS 1225292-17-0)、乙基碳酸3-(4-氯-2,6-二甲基苯基)-8-甲氧基-2-側氧基 -1,8-二氮雜螺[4.5]癸-3-烯-4-基酯(來自EP 2647626)(CAS-1440516-42-6)、4-(丁-2-炔-1-基氧)-6-(3,5-二甲基哌啶-1-基)-5-氟嘧啶(來自WO2004/099160)(CAS 792914-58-0)、PF1364(來自JP2010/018586)(CAS Reg.No.1204776-60-2)、N-[(2E)-1-[(6-氯吡啶-3-基)甲基]吡啶-2(1H)-亞基]-2,2,2-三氟乙醯胺(來自WO2012/029672)(CAS 1363400-41-2)、(3E)-3-[1-[(6-氯-3-吡啶基)甲基]-2-吡啶亞基]-1,1,1-三氟丙-2-酮(來自WO2013/144213)(CAS 1461743-15-6)、N-[3-(苯甲基胺甲醯基)-4-氯苯基]-1-甲基-3-(五氟乙基)-4-(三氟甲基)-1H-吡唑-5-甲醯胺(來自WO2010/051926)(CAS 1226889-14-0)、5-溴-4-氯-N-[4-氯-2-甲基-6-(甲基胺甲醯基)苯基]-2-(3-氯-2-吡啶基)吡唑-3-甲醯胺(來自CN103232431)(CAS 1449220-44-3)、4-[5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異唑基]-2-甲基-N-(順式-1-氧離子基-3-硫雜環丁烷基)苯甲醯胺、4-[5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異唑基]-2-甲基-N-(反式-1-氧離子基-3-硫雜環丁烷基)苯甲醯胺與4-[(5S)-5-(3,5-二氯苯基)-4,5-二氫-5-(三氟甲基)-3-異唑基]-2-甲基-N-(順式-1-氧離子基-3-硫雜環丁烷基)苯甲醯胺(來自WO 2013/050317 A1)(CAS 1332628-83-7)、N-[3-氯-1-(3-吡啶基)-1H-吡唑-4-基]-N-乙基-3-[(3,3,3-三氟丙基)亞磺醯基]丙醯胺、(+)-N-[3-氯-1-(3-吡啶基)-1H-吡唑-4-基]-N-乙基-3-[(3,3,3-三氟丙基)亞磺醯基]丙醯胺與(-)-N-[3-氯-1-(3-吡啶基)-1H-吡唑-4-基]-N-乙基-3-[(3,3,3-三氟丙基)亞磺醯基]丙醯胺(來自WO 2013/162715 A2、WO 2013/162716 A2、US 2014/0213448 A1)(CAS 1477923-37-7)、5-[[(2E)-3-氯-2-丙烯-1-基]胺基]-1-[2,6-二氯-4-(三氟甲基)苯基]-4-[(三氟甲基)亞磺醯基]-1H-吡唑-3-甲腈(來自CN 101337937 A)(CAS 1105672-77-2)、3-溴-N-[4-氯-2-甲基-6-[(甲基胺基)硫代甲基]苯基]-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲醯胺(Liudaibenjiaxuanan，來自CN 103109816 A)(CAS 1232543-85-9)；N-[4-氯-2-[[(1,1-二甲基乙基)胺基]羰基]-6-甲基苯基]-1-(3-氯-2-吡啶基)-3-(氟甲氧基)-1H-吡唑-5-甲醯胺(來自WO 2012/034403 A1)(CAS 1268277-22-0)、N-[2-(5-胺基-1,3,4-噻二唑-2-基)-4-氯-6-甲基苯基]-3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲醯胺(來自WO 2011/085575 A1)(CAS 1233882-22-8)、4-[3-[2,6-二氯-4-[(3,3-二氯-2-丙烯-1-基)氧]苯氧基]丙氧基]-2-甲氧基-6-(三氟甲基)嘧啶(來自CN 101337940 A)(CAS 1108184-52-6)；(2E)-與2(Z)-2-[2-(4-氰基苯基)-1-[3-(三氟甲基)苯基]亞乙基]-N-[4-(二氟甲氧基)苯基]肼甲醯胺(來自CN 101715774 A)(CAS 1232543-85-9)；環丙烷羧酸3-(2,2-二氯乙烯基)-2,2-二甲基-4-(1H-苯并咪唑-2-基)苯基酯(來自CN 103524422 A)(CAS 1542271-46-4)；(4aS)-7-氯-2,5-二氫-2-[[(甲氧基羰基)[4-[(三氟甲基)硫]苯基]胺基]羰基]茚并[1,2-e][1,3,4]二-4a(3H)-羧酸甲基酯(來自CN 102391261 A)(CAS 1370358-69-2)；6-去氧-3-O-乙基-2,4-二-O-甲基-1-[N-[4-[1-[4-(1,1,2,2,2-五氟乙氧基)苯基]-1H-1,2,4-三唑-3-基]苯基]胺甲酸酯]-α-L-哌喃甘露糖(來自US 2014/0275503 A1)(CAS 1181213-14-8)；8-(2-環丙基甲氧基-4-三氟甲基苯氧基)-3-(6-三氟甲基嗒-3-基)-3-氮雜雙環[3.2.1]辛烷(CAS 1253850-56-4)、(8-反側)-8-(2-環丙基甲氧基-4-三氟甲基苯氧基)-3-(6-三氟甲基嗒-3-基)-3-氮雜雙環[3.2.1]辛烷(CAS 933798-27-7)、(8-同側)-8-(2-環丙基甲氧基-4-三氟甲基苯氧基)-3-(6-三氟甲基嗒-3-基)-3-氮雜雙環[3.2.1]辛烷(來自WO 2007040280 A1、WO 2007040282 A1)(CAS 934001-66-8)與N-[3-氯-1-(3-吡啶基)-1H-吡唑-4-基]-N-乙基-3-[(3,3,3-三氟丙基)硫]丙醯胺(來自WO 2015/058021 A1、WO 2015/058028 A1)(CAS 1477919-27-9)。 (28) Ryanodine receptor modulators, for example, diamines, for example, chlorantraniliprole, cyantraniliprole and flubendiamide, other active ingredients, For example: afidopyropen, afoxolaner, azadirachtin, benclothiaz, benzoximate, bifenazate, broflanilide , new bromopropylate, chinomethionat, chloroprallethrin, cryolite, cyclaniliprole, cycloxaprid, chlorofluorocyanide Cyhalodiamide, diclofenac (dicloromezotiaz), dicofol, metofluthrin, momofluthrin, flometoquin, fluazaindolizine, fluensulfone , flufenerim, flufenoxystrobin, flufiprole, fluhexafon, fluopyram, flularaner, fluocinolone Fluxametamide, fufenozide, guadipyr, heptafluthrin, imidaclothiz, iprodione, kappa bifenthrin ), kappa tefluthrin, lotilaner, meperfluthrin, paichongding, pyridalyl, pyrifluquinazon, Pyrimidostrobin, spirobudiclofen, tetramethylfluthrin, tetraniliprole, tetrachlorantraniliprole, tioxazafen, thiofluoride Thiofluoximate, triflumezopyrim, and methyl iodide; Based formulation (I-1582, BioNeem, Votivo ) Bacillus firmus (Bacillus firmus), the following compounds: 1- {2-fluoro-4-methyl-5 - [(2,2,2-trifluoroethyl Sulfosyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazole-5-amine (from WO2006/043635) (CAS 885026-50-6), {1 '-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-5-fluorospiro[吲哚-3,4'-piperidine]-1(2H)-yl }(2-Chloropyridin-4-yl)methanone (from WO2003/106457) (CAS 637360-23-7), 2-chloro-N-[2-{1-[(2E)-3-(4- Chlorophenyl)prop-2-en-1-yl]piperidin-4-yl}-4-(trifluoromethyl)phenyl]isonazinamide (from WO2006/003494) (CAS 872999-66-1 , 3-(4-Chloro-2,6-dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]indole-3-en-2-one (from WO 2010052161) (CAS 1225292-17-0), 3-(4-chloro-2,6-dimethylphenyl)-8-methoxy-2-oxooxy-1,8-ethyl carbonate -diazaspiro[4.5]dec-3-en-4-yl ester (from EP 2647626) (CAS-1440516-42-6), 4-(but-2-yn-1-yloxy)-6- (3,5-Dimethylpiperidin-1-yl)-5-fluoropyrimidine (from WO2004/099160) (CAS 792914-58-0), PF1364 (from JP2010/018586) (CAS Reg. No. 1204776- 60-2), N-[(2E)-1-[(6-chloropyridin-3-yl)methyl] Pyridine-2(1H)-ylidene-2,2,2-trifluoroacetamide (from WO2012/029672) (CAS 1363400-41-2), (3E)-3-[1-[(6- Chloro-3-pyridyl)methyl]-2-pyridinylene]-1,1,1-trifluoropropan-2-one (from WO 2013/144213) (CAS 1461743-15-6), N-[3 -(benzylaminomethylmercapto)-4-chlorophenyl]-1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-formamidine Amine (from WO2010/051926) (CAS 1226889-14-0), 5-bromo-4-chloro-N-[4-chloro-2-methyl-6-(methylamine-methyl)phenyl]- 2-(3-Chloro-2-pyridyl)pyrazole-3-carboxamide (from CN103232431) (CAS 1449220-44-3), 4-[5-(3,5-dichlorophenyl)-4 ,5-dihydro-5-(trifluoromethyl)-3-iso Azyl]-2-methyl-N-(cis-1-iodoxy-3-thietyl)benzamide, 4-[5-(3,5-dichlorophenyl) -4,5-dihydro-5-(trifluoromethyl)-3-iso Azyl]-2-methyl-N-(trans-1-oxo-3-thiat-butyl)benzamide with 4-[(5S)-5-(3,5-di Chlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-iso Azolyl]-2-methyl-N-(cis-1-iodoxy-3-thietanealkyl)benzamide (from WO 2013/050317 A1) (CAS 1332628-83-7) , N-[3-Chloro-1-(3-pyridyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfinium Propionamide, (+)-N-[3-chloro-1-(3-pyridyl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3 -trifluoropropyl)sulfinyl]propanamine and (-)-N-[3-chloro-1-(3-pyridyl)-1H-pyrazol-4-yl]-N-ethyl- 3-[(3,3,3-Trifluoropropyl)sulfinyl]propanamine (from WO 2013/162715 A2, WO 2013/162716 A2, US 2014/0213448 A1) (CAS 1477923-37-7 , 5-[[(2E)-3-chloro-2-propen-1-yl]amino]-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4- [(Trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile (from CN 101337937 A) (CAS 1105672-77-2), 3-bromo-N-[4-chloro-2- Methyl-6-[(methylamino)thiomethyl]phenyl]-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamide (Liudaibenjiaxuanan from CN 103109816 A) (CAS 1232543-85-9); N-[4-chloro-2-[[(1,1-dimethylethyl)amino]carbonyl]-6-methylphenyl]-1-( 3-Chloro-2-pyridyl)-3-(fluoromethoxy)-1H-pyrazole-5-carboxamide (from WO 2012/034403 A1) (CA S 1268277-22-0), N-[2-(5-Amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo- 1-(3-Chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide (from WO 2011/085575 A1) (CAS 1233882-22-8), 4-[3-[2,6- Dichloro-4-[(3,3-dichloro-2-propen-1-yl)oxy]phenoxy]propoxy]-2-methoxy-6-(trifluoromethyl)pyrimidine (from CN 101337940 A) (CAS 1108184-52-6); (2E)- and 2(Z)-2-[2-(4-cyanophenyl)-1-[3-(trifluoromethyl)phenyl ]]ethyl]-N-[4-(difluoromethoxy)phenyl]indolecarboxamide (from CN 101715774 A) (CAS 1232543-85-9); cyclopropanecarboxylic acid 3-(2,2) -dichlorovinyl)-2,2-dimethyl-4-(1H-benzimidazol-2-yl)phenyl ester (from CN 103524422 A) (CAS 1542271-46-4); (4aS)- 7-Chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-[(trifluoromethyl)sulfanyl]phenyl]amino]carbonyl]indole[1,2-e] [1,3,4] two -4a(3H)-carboxylic acid methyl ester (from CN 102391261 A) (CAS 1370358-69-2); 6-deoxy-3-O-ethyl-2,4-di-O-methyl-1 -[N-[4-[1-[4-(1,1,2,2,2-pentafluoroethoxy)phenyl]-1H-1,2,4-triazol-3-yl]benzene Carbamate]-α-L-mannopyrose (from US 2014/0275503 A1) (CAS 1181213-14-8); 8-(2-cyclopropylmethoxy-4-trifluoromethyl) Phenoxy)-3-(6-trifluoromethylhydrazine 3-yl)-3-azabicyclo[3.2.1]octane (CAS 1253850-56-4), (8-reverse)-8-(2-cyclopropylmethoxy-4-trifluoro Methylphenoxy)-3-(6-trifluoromethylhydrazine -3-yl)-3-azabicyclo[3.2.1]octane (CAS 933798-27-7), (8-isolateral)-8-(2-cyclopropylmethoxy-4-trifluoro Methylphenoxy)-3-(6-trifluoromethylhydrazine -3-yl)-3-azabicyclo[3.2.1]octane (from WO 2007040280 A1, WO 2007040282 A1) (CAS 934001-66-8) and N-[3-chloro-1-(3-pyridine) -1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)thio]propanamide (from WO 2015/058021 A1, WO 2015/058028 A1) (CAS 1477919-27-9).

殺真菌劑Fungicide

本文中以其俗名稱呼之活性成份為已知者且說明於例如：「The Pesticide Manual」(British Crop Protection Council，第16版)或可搜尋網際網路(例如：http：//www.alanwood.net/pesticides)。 The active ingredients referred to herein by their common names are known and described, for example, in "The Pesticide Manual" (British Crop Protection Council, 16th Edition) or on the Internet (for example: http://www.alanwood. Net/pesticides).

(1)至(15)類所列之所有混合組份若可能時可依其官能基時，可視需要與合適之鹼類或酸類形成鹽類。(1)至(15)類所列之所有殺真菌混合組份若可能時，亦可包括互變異構型。 All of the mixed components listed in categories (1) to (15) may, if possible, form a salt with a suitable base or acid, depending on the functional group. All fungicidal mixed components listed in categories (1) to (15) may also include tautomeric forms if possible.

1)麥角固醇生合成抑制劑，例如：(1.001)西普康唑(cyproconazole)、(1.002)吩康唑(difenoconazole)、(1.003)環氧克唑(epoxiconazole)、(1.004)吩醯胺(fenhexamide)、(1.005)芬普定(fenpropidin)、(1.006)芬普福(fenpropimorph)、(1.007)胺苯吡菌酮(fenpyrazamine)、(1.008)伏 克康唑(fluquinconazole)、(1.009)護汰芬(flutriafol)、(1.010)依滅列(imazalil)、(1.011)依滅列硫酸鹽(imazalil sulphate)、(1.012)抑普康唑(ipconazole)、(1.013)滅康唑(metconazole)、(1.014)麥克坦尼(myclobutanil)、(1.015)巴克素(paclobutrazole)、(1.016)撲克樂(prochloraz)、(1.017)普克利(propiconazole)、(1.018)普賽康唑(pr0thi0conazole)、(1.019)吡啶菌唑(pyrisoxazole)、(1.020)賜必安(spiroxamine)、(1.021)得克利(tebuconazole)、(1.022)特康唑(tetraconazole)、(1.023)三泰隆(triadimenol)、(1.024)賽得莫(tridemorph)、(1.025)三狄康唑(triticonazole)、(1.026)(1R,2S,5S)-5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環戊醇、(1.027)(1S,2R,5R)-5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環戊醇、(1.028)(2R)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.029)(2R)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.030)(2R)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.031)(2S)-2-(1-氯環丙基)-4-[(1R)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.032)(2S)-2-(1-氯環丙基)-4-[(1S)-2,2-二氯環丙基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.033)(2S)-2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.034)(R)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-唑-4-基](吡啶-3-基)甲醇、(1.035)(S)-[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-唑-4-基](吡啶-3-基)甲醇、(1.036)[3-(4-氯-2-氟苯基)-5-(2,4-二氟苯基)-1,2-唑-4-基](吡啶-3-基)甲醇、(1.037)1-({(2R,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧雜環戊烷-2-基}甲基)-1H-1,2,4-三唑、(1.038)1-({(2S,4S)-2-[2-氯-4-(4-氯苯氧基)苯基]-4-甲基-1,3-二氧雜環戊烷-2-基}甲基)-1H-1,2,4-三唑、(1.039)硫氰酸1-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基酯、(1.040)硫氰酸1-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基酯、(1.041)硫氰酸1-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑-5-基酯、(1.042)2-[(2R,4R,5R)-1-(2,4-二氯苯基)-5-羥 基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.043)2-[(2R,4R,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.044)2-[(2R,4S,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.045)2-[(2R,4S,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.046)2-[(2S,4R,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.047)2-[(2S,4R,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.048)2-[(2S,4S,5R)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.049)2-[(2S,4S,5S)-1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.050)2-[1-(2,4-二氯苯基)-5-羥基-2,6,6-三甲基庚烷-4-基]-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.051)2-[2-氯-4-(2,4-二氯苯氧基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.052)2-[2-氯-4-(4-氯苯氧基)苯基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.053)2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丁-2-醇、(1.054)2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)戊-2-醇、(1.055)2-[4-(4-氯苯氧基)-2-(三氟甲基)苯基]-1-(1H-1,2,4-三唑-1-基)丙-2-醇、(1.056)2-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.057)2-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.058)2-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-2,4-二氫-3H-1,2,4-三唑-3-硫酮、(1.059)5-(4-氯苯甲基)-2-(氯甲基)-2-甲基-1-(1H-1,2,4-三唑-1-基甲基)環戊醇、(1.060)5-(烯丙基硫基)-1-{[3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.061)5-(烯丙基硫基)-1-{[rel(2R,3R)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.062)5-(烯丙基硫基)-1-{[rel(2R,3S)-3-(2-氯苯基)-2-(2,4-二氟苯基)環氧乙烷-2-基]甲基}-1H-1,2,4-三唑、(1.063)N'-(2,5-二甲基-4-{[3-(1,1,2,2-四氟乙氧基)苯基]硫基}苯基)-N-乙基-N-甲基甲脒、(1.064)N'-(2,5-二甲基-4-{[3-(2,2,2-三氟乙氧基)苯基]硫基} 苯基)-N-乙基-N-甲基甲脒、(1.065)N'-(2,5-二甲基-4-{[3-(2,2,3,3-四氟丙氧基)苯基]硫基}苯基)-N-乙基-N-甲基甲脒、(1.066)N'-(2,5-二甲基-4-{[3-(五氟乙氧基)苯基]硫基}苯基)-N-乙基-N-甲基甲脒、(1.067)N'-(2,5-二甲基-4-{3-[(1,1,2,2-四氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基甲脒、(1.068)N'-(2,5-二甲基-4-{3-[(2,2,2-三氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基甲脒、(1.069)N'-(2,5-二甲基-4-{3-[(2,2,3,3-四氟丙基)硫基]苯氧基}苯基)-N-乙基-N-甲基甲脒、(1.070)N'-(2,5-二甲基-4-{3-[(五氟乙基)硫基]苯氧基}苯基)-N-乙基-N-甲基甲脒、(1.071)N'-(2,5-二甲基-4-苯氧基苯基)-N-乙基-N-甲基甲脒、(1.072)N'-(4-{[3-(二氟甲氧基)苯基]硫基}-2,5-二甲基苯基)-N-乙基-N-甲基甲脒、(1.073)N'-(4-{3-[(二氟甲基)硫基]苯氧基}-2,5-二甲基苯基)-N-乙基-N-甲基甲脒、(1.074)N'-[5-溴-6-(2,3-二氫-1H-茚-2-基氧)-2-甲基吡啶-3-基]-N-乙基-N-甲基甲脒、(1.075)N'-{4-[(4,5-二氯-1,3-噻唑-2-基)氧]-2,5-二甲基苯基}-N-乙基-N-甲基甲脒、(1.076)N'-{5-溴-6-[(1R)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基甲脒、(1.077)N'-{5-溴-6-[(1S)-1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基甲脒、(1.078)N'-{5-溴-6-[(順式-4-異丙基環己基)氧]-2-甲基吡啶-3-基}-N-乙基-N-甲基甲脒、(1.079)N'-{5-溴-6-[(反式-4-異丙基環己基)氧]-2-甲基吡啶-3-基}-N-乙基-N-甲基甲脒、(1.080)N'-{5-溴-6-[1-(3,5-二氟苯基)乙氧基]-2-甲基吡啶-3-基}-N-乙基-N-甲基甲脒、(1.081)美氟康唑(mefentrifluconazole)、(1.082)抑氟康唑(ipfentrifluconazole)。 1) ergosterol biosynthesis inhibitors, for example: (1.001) cyproconazole, (1.002) difenoconazole, (1.003) epoxiconazole, (1.004) Amine (fenhexamide), (1.005) fenpropidin, (1.006) fenpropimorph, (1.007) fenpyrazamine, (1.008) fluquinconazole, (1.009) ) flutriafol, (1.010) imazalil, (1.011) imazalil sulphate, (1.012) ipconazole, (1.013) thiconazole (metconazole) ), (1.014) myclobutanil, (1.015) paclobutrazole, (1.016) prochloraz, (1.017) propiconazole, (1.018) pr0thi0conazole, (1.019) pyrisoxazole, (1.020) spiroxamine, (1.021) tebuconazole, (1.022) tetraconazole, (1.023) triadimenol, (1.024) ) tridemorph, (1.025) triticonazole, (1.026) (1R, 2S, 5S)-5-(4-chlorobenzyl)-2-(chloromethyl)-2 -methyl-1-(1H-1,2,4-triazol-1-yl-methyl) Cyclopentanol, (1.027) (1S, 2R, 5R)-5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H-1,2, 4-triazol-1-ylmethyl)cyclopentanol, (1.028)(2R)-2-(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl] 1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.029)(2R)-2-(1-chlorocyclopropyl)-4-[(1S)- 2,2-Dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, (1.030)(2R)-2-[4-(4- Chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol, (1.031)(2S)-2 -(1-chlorocyclopropyl)-4-[(1R)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-triazol-1-yl)but-2- Alcohol, (1.032)(2S)-2-(1-chlorocyclopropyl)-4-[(1S)-2,2-dichlorocyclopropyl]-1-(1H-1,2,4-tri Zin-1-yl)butan-2-ol, (1.033)(2S)-2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H- 1,2,4-triazol-1-yl)propan-2-ol, (1.034)(R)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluoro Phenyl)-1,2- Zin-4-yl](pyridin-3-yl)methanol, (1.035)(S)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)- 1,2- Zin-4-yl](pyridin-3-yl)methanol, (1.036)[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-1,2- Zin-4-yl](pyridin-3-yl)methanol, (1.037) 1-({(2R,4S)-2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4 -methyl-1,3-dioxol-2-yl}methyl)-1H-1,2,4-triazole, (1.038) 1-({(2S,4S)-2-[ 2-Chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1H-1,2,4- Triazole, (1.039) 1-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-thiocyanate 1,2,4-triazol-5-yl ester, (1.040) 1-{[rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluoro) thiocyanate Phenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl ester, (1.041) 1-{[rel(2R,3S)-3 -(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazol-5-yl ester, (1.042) 2-[(2R,4R,5R)-1-(2,4-Dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2, 4-Dihydro-3H-1,2,4-triazole-3-thione, (1.043)2-[(2R,4R,5S)-1-(2,4-dichlorophenyl)-5- Hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.044)2-[(2R ,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1 , 2,4-triazole-3-thione, (1.045)2-[(2R,4S,5S)-1-(2 ,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3- Thiol, (1.046) 2-[(2S,4R,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl] -2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.047)2-[(2S,4R,5S)-1-(2,4-dichlorophenyl) -5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.048)2- [(2S,4S,5R)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro- 3H-1,2,4-triazole-3-thione, (1.049)2-[(2S,4S,5S)-1-(2,4-dichlorophenyl)-5-hydroxy-2,6 ,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.050)2-[1-(2,4- Dichlorophenyl)-5-hydroxy-2,6,6-trimethylheptan-4-yl]-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.051) 2-[2-Chloro-4-(2,4-dichlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)propan-2-ol , (1.052) 2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, ( 1.053) 2-[4-(4-Chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazol-1-yl)butan-2- Alcohol, (1.054) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazole-1- Pentan-2-ol, (1.055) 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1H-1,2,4-triazole- 1-yl)propan-2-ol, (1.056) 2-{[3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl }-2,4-Dihydro-3H-1,2,4-triazole-3-thione, (1.057)2-{[rel(2R,3R)-3-(2-chlorophenyl)-2 -(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4-dihydro-3H-1,2,4-triazole-3-thione, (1.058) 2-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-2,4- Dihydro-3H-1,2,4-triazole-3-thione, (1.059) 5-(4-chlorobenzyl)-2-(chloromethyl)-2-methyl-1-(1H -1,2,4-triazol-1-ylmethyl)cyclopentanol, (1.060) 5-(allylthio)-1-{[3-(2-chlorophenyl)-2-( 2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole, (1.061) 5-(allylthio)-1-{[ Rel(2R,3R)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4- Triazole, (1.062) 5-(allylthio)-1-{[rel(2R,3S)-3-(2-chlorophenyl)-2-(2,4-difluorophenyl) ring Oxyethane-2-yl]methyl}-1H-1,2,4-triazole, (1.063) N'-(2,5-dimethyl-4-{[3-(1,1,2) ,2-tetrafluoroethoxy)phenyl]thio}phenyl)-N-ethyl- N-methylformamidine, (1.064) N'-(2,5-dimethyl-4-{[3-(2,2,2-trifluoroethoxy)phenyl]thio}phenyl) -N-ethyl-N-methylformamidine, (1.065) N'-(2,5-dimethyl-4-{[3-(2,2,3,3-tetrafluoropropoxy)benzene (thio)}phenyl)-N-ethyl-N-methylformamidine, (1.066) N'-(2,5-dimethyl-4-{[3-(pentafluoroethoxy)benzene (thio)}phenyl)-N-ethyl-N-methylformamidine, (1.067) N'-(2,5-dimethyl-4-{3-[(1,1,2,2) -tetrafluoroethyl)thio]phenoxy}phenyl)-N-ethyl-N-methylformamidine, (1.068) N'-(2,5-dimethyl-4-{3-[ (2,2,2-Trifluoroethyl)thio]phenoxy}phenyl)-N-ethyl-N-methylformamidine, (1.069) N'-(2,5-dimethyl- 4-{3-[(2,2,3,3-tetrafluoropropyl)thio]phenoxy}phenyl)-N-ethyl-N-methylformamidine, (1.070) N'-( 2,5-Dimethyl-4-{3-[(pentafluoroethyl)thio]phenoxy}phenyl)-N-ethyl-N-methylformamidine, (1.071) N'-( 2,5-Dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylformamidine, (1.072) N'-(4-{[3-(difluoromethoxy)benzene (thio)}-2,5-dimethylphenyl)-N-ethyl-N-methylformamidine, (1.073) N'-(4-{3-[(difluoromethyl)thio) Phenoxy}-2,5-dimethylphenyl)-N-ethyl-N-methylformamidine, (1.074) N'-[5 -Bromo-6-(2,3-dihydro-1H-indol-2-yloxy)-2-methylpyridin-3-yl]-N-ethyl-N-methylformamidine, (1.075)N '-{4-[(4,5-Dichloro-1,3-thiazol-2-yl)oxy]-2,5-dimethylphenyl}-N-ethyl-N-methylformamidine, (1.076) N'-{5-Bromo-6-[(1R)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridin-3-yl}-N-ethyl -N-methylformamidine, (1.077) N'-{5-bromo-6-[(1S)-1-(3,5-difluorophenyl)ethoxy]-2-methylpyridine-3 -yl}-N-ethyl-N-methylformamidine, (1.078) N'-{5-bromo-6-[(cis-4-isopropylcyclohexyl)oxy]-2-methylpyridine -3-yl}-N-ethyl-N-methylformamidine, (1.079) N'-{5-bromo-6-[(trans-4-isopropylcyclohexyl)oxy]-2-methyl Pyridin-3-yl}-N-ethyl-N-methylformamidine, (1.080) N'-{5-bromo-6-[1-(3,5-difluorophenyl)ethoxy] -2-methylpyridin-3-yl}-N-ethyl-N-methylformamidine, (1.081) mefentrifluconazole, (1.082) ipfentrifluconazole.

2)複合物I或II之呼吸鏈抑制劑，例如：(2.001)苯索伏比(benzovindiflupyr)、(2.002)必賽吩(bixafen)、(2.003)保卡利(boscalid)、(2.004)卡布辛(carboxin)、(2.005)護派楠(fluopyram)、(2.006)護坦尼(flutolanil)、(2.007)護賽保(fluxapyroxad)、(2.008)福滅普(furametpyr)、(2.009)抑吩滅(isofetamid)、(2.010)抑本散(isopyrazam)(反側-差向對映異構物1R,4S,9S)、(2.011)抑本散(反側-差向對映異構物1S,4R,9R)、(2.012)抑本散(反側-差向異構消旋物1RS,4SR,9SR)、(2.013)抑本散(同側-差向異構消旋物1RS,4SR,9RS與反側-差向異構消旋物1RS,4SR,9SR之混合物)、(2.014)抑本散(同側-差向對映異構物 1R,4S,9R)、(2.015)抑本散(同側-差向對映異構物1S,4R,9S)、(2.016)抑本散(同側-差向異構消旋物1RS,4SR,9RS)、(2.017)本福吩(penflufen)、(2.018)本賽能(penthiopyrad)、(2.019)必福吩(pydiflumetofen)、(2.020)必福滅(pyraziflumid)、(2.021)速達散(sedaxane)、(2.022)1,3-二甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-1H-吡唑-4-甲醯胺、(2.023)1,3-二甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.024)1,3-二甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.025)1-甲基-3-(三氟甲基)-N-[2'-(三氟甲基)聯苯-2-基]-1H-吡唑-4-甲醯胺、(2.026)2-氟-6-(三氟甲基)-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)苯甲醯胺、(2.027)3-(二氟甲基)-1-甲基-N-(1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-1H-吡唑-4-甲醯胺、(2.028)3-(二氟甲基)-1-甲基-N-[(3R)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.029)3-(二氟甲基)-1-甲基-N-[(3S)-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1H-吡唑-4-甲醯胺、(2.030)3-(二氟甲基)-N-(7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基)-1-甲基-1H-吡唑-4-甲醯胺、(2.031)3-(二氟甲基)-N-[(3R)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺、(2.032)3-(二氟甲基)-N-[(3S)-7-氟-1,1,3-三甲基-2,3-二氫-1H-茚-4-基]-1-甲基-1H-吡唑-4-甲醯胺、(2.033)5,8-二氟-N-[2-(2-氟-4-{[4-(三氟甲基)吡啶-2-基]氧}苯基)乙基]喹唑啉-4-胺、(2.034)N-(2-環戊基-5-氟苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.035)N-(2-第三丁基-5-甲基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.036)N-(2-第三丁基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.037)N-(5-氯-2-乙基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.038)N-(5-氯-2-異丙基苯甲基)-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.039)N-[(1R,4S)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐基萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.040)N-[(1S,4R)-9-(二氯亞甲基)-1,2,3,4-四氫-1,4-甲撐基萘-5-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.041)N-[1-(2,4-二氯苯基)-1-甲氧基丙-2-基]-3-(二氟甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.042)N-[2-氯-6-(三氟甲基)苯甲基]-N-環丙基 -3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.043)N-[3-氯-2-氟-6-(三氟甲基)苯甲基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.044)N-[5-氯-2-(三氟甲基)苯甲基]-N-環丙基-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.045)N-環丙基-3-(二氟甲基)-5-氟-1-甲基-N-[5-甲基-2-(三氟甲基)苯甲基]-1H-吡唑-4-甲醯胺、(2.046)N-環丙基-3-(二氟甲基)-5-氟-N-(2-氟-6-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.047)N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基-5-甲基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.048)N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲硫醯胺、(2.049)N-環丙基-3-(二氟甲基)-5-氟-N-(2-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.050)N-環丙基-3-(二氟甲基)-5-氟-N-(5-氟-2-異丙基苯甲基)-1-甲基-1H-吡唑-4-甲醯胺、(2.051)N-環丙基-3-(二氟甲基)-N-(2-乙基-4,5-二甲基苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.052)N-環丙基-3-(二氟甲基)-N-(2-乙基-5-氟苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.053)N-環丙基-3-(二氟甲基)-N-(2-乙基-5-甲基苯甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.054)N-環丙基-N-(2-環丙基-5-氟苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.055)N-環丙基-N-(2-環丙基-5-甲基苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺、(2.056)N-環丙基-N-(2-環丙基苯甲基)-3-(二氟甲基)-5-氟-1-甲基-1H-吡唑-4-甲醯胺。 2) Respiratory chain inhibitors of complex I or II, for example: (2.001) benzovindiflupyr, (2.002) bixafen, (2.003) boscalid, (2.004) card Carboxin, (2.005) fluopyram, (2.006) flutolanil, (2.007) fluxapyroxad, (2.008) furametpyr, (2.009) Isofetamid, (2.010) isoprozam (reverse-diverse enantiomers 1R, 4S, 9S), (2.011) sputum (negative-diverse enantiomer) 1S, 4R, 9R), (2.012) saponin (reverse-episomeric racemate 1RS, 4SR, 9SR), (2.013) saponin (ipsilateral-episomeric racemate 1RS, 4SR, 9RS and the mixture of the opposite side-episomeric racemate 1RS, 4SR, 9SR), (2.014) inhibited the dispersion (i-side-diverse enantiomers 1R, 4S, 9R), (2.015)本本散(i-side-diverse enantiomers 1S, 4R, 9S), (2.016) saponin (ipsilateral-episomeric racemate 1RS, 4SR, 9RS), (2.017) Benfu Penflufen, (2.018) penthiopyrad, (2.019) pydiflumetofen, (2.020) pyrazilflumid, (2.021) sedaxane, (2.022) 1,3 -dimethyl-N-(1,1,3-three Methyl-2,3-dihydro-1H-indol-4-yl)-1H-pyrazole-4-carboxamide, (2.023) 1,3-dimethyl-N-[(3R)-1, 1,3-Trimethyl-2,3-dihydro-1H-indol-4-yl]-1H-pyrazole-4-carboxamide, (2.024) 1,3-dimethyl-N-[( 3S)-1,1,3-trimethyl-2,3-dihydro-1H-indol-4-yl]-1H-pyrazole-4-carboxamide, (2.025) 1-methyl-3- (trifluoromethyl)-N-[2'-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.026) 2-fluoro-6-(trifluoro Methyl)-N-(1,1,3-trimethyl-2,3-dihydro-1H-indol-4-yl)benzamide, (2.027)3-(difluoromethyl)-1 -methyl-N-(1,1,3-trimethyl-2,3-dihydro-1H-indol-4-yl)-1H-pyrazole-4-carboxamide, (2.028)3-( Difluoromethyl)-1-methyl-N-[(3R)-1,1,3-trimethyl-2,3-dihydro-1H-indol-4-yl]-1H-pyrazole-4 -carbamamine, (2.029) 3-(difluoromethyl)-1-methyl-N-[(3S)-1,1,3-trimethyl-2,3-dihydro-1H-indole- 4-yl]-1H-pyrazole-4-carboxamide, (2.030) 3-(difluoromethyl)-N-(7-fluoro-1,1,3-trimethyl-2,3-di Hydrogen-1H-indol-4-yl)-1-methyl-1H-pyrazole-4-carboxamide, (2.031) 3-(difluoromethyl)-N-[(3R)-7-fluoro- 1,1,3-trimethyl-2,3-dihydro-1H-indol-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (2.032) 3-(difluoro Methyl)-N-[(3S)-7-fluoro-1,1,3- Methyl-2,3-dihydro-1H-indol-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, (2.033) 5,8-difluoro-N-[2- (2-Fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine, (2.034) N-(2-cyclopentyl) -5-fluorobenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.035) N-( 2-tert-butyl-5-methylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide , (2.036) N-(2-t-butylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-methyl Indoleamine, (2.037) N-(5-chloro-2-ethylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole 4-carbamamine, (2.038) N-(5-chloro-2-isopropylbenzyl)-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl -1H-pyrazole-4-carboxamide, (2.039) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methyl Benzylnaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.040) N-[(1S,4R)-9-(two Chloromethyl)-1,2,3,4-tetrahydro-1,4-methylenenaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole- 4-Proline, (2.041) N-[1-(2,4-dichlorophenyl)-1-methoxyprop-2- ]-3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.042) N-[2-chloro-6-(trifluoromethyl)benzyl]- N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.043) N-[3-chloro-2-fluoro-6 -(Trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.044) N-[5-Chloro-2-(trifluoromethyl)benzyl]-N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4 -Procarbamide, (2.045) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-1-methyl-N-[5-methyl-2-(trifluoromethyl)benzene -1H-pyrazole-4-carboxamide, (2.046) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-fluoro-6-isopropylbenzene 1-methyl-1H-pyrazole-4-carboxamide, (2.047) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(2-isopropyl- 5-methylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.048) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-( 2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-methylthioguanamine, (2.049) N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N -(2-isopropylbenzyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.050) N-cyclopropyl-3-(difluoromethyl)-5-fluoro- N-(5-fluoro-2-isopropylbenzyl)-1- Methyl-1H-pyrazole-4-carboxamide, (2.051) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-4,5-dimethylbenzyl -5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.052) N-cyclopropyl-3-(difluoromethyl)-N-(2-ethyl-5- Fluorobenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.053) N-cyclopropyl-3-(difluoromethyl)-N-(2-B 5-methylbenzyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.054) N-cyclopropyl-N-(2-cyclopropyl-5 -fluorobenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.055) N-cyclopropyl-N-(2- Cyclopropyl-5-methylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide, (2.056) N-cyclopropyl -N-(2-Cyclopropylbenzyl)-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide.

3)複合物III之呼吸鏈抑制劑，例如：(3.001)辛唑嘧菌胺(ametoctradin)、(3.002)安美速(amisulbrom)、(3.003)亞托敏(azoxystrobin)、(3.004)甲香菌酯(coumethoxystrobin)、(3.005)丁香菌酯(coumoxystrobin)、(3.006)賽發滅(cyazofamid)、(3.007)醚菌胺(dimoxystrobin)、(3.008)烯肟菌酯(enoxastrobin)、(3.009)芬色丹(famoxadon)、(3.010)芬滅酮(fenamidon)、(3.011)吩嘧菌酯(flufenoxystrobin)、(3.012)氟嘧菌酯(fluoxastrobin)、(3.013)甲基醚菌酯(kresoxim-methyl)、(3.014)氧菌胺(metominostrobin)、(3.015)肟醚菌胺(orysastrobin)、(3.016)啶氧菌酯(picoxystrobin)、(3.017)唑菌胺酯(pyraclostrobin)、(3.018)唑胺菌酯(pyrametostrobin)、(3.019)唑菌酯(pyraoxystrobin)、(3.020)三氟敏(trifloxystrobin)、(3.021)(2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-氟-2-苯基乙烯基]氧}苯基)亞乙基]胺基} 氧)甲基]苯基}-2-(甲氧基亞胺基)-N-甲基乙醯胺、(3.022)(2E,3Z)-5-{[1-(4-氯苯基)-1H-吡唑-3-基]氧}-2-(甲氧基亞胺基)-N,3-二甲基戊-3-烯醯胺、(3.023)(2R)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺、(3.024)(2S)-2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺、(3.025)(3S,6S,7R,8R)-8-苯甲基-3-[({3-[(異丁醯基氧)甲氧基]-4-甲氧基吡啶-2-基}羰基)胺基]-6-甲基-4,9-二側氧基-1,5-二氧雜環壬烷-7-基2-甲基丙酸酯、(3.026)2-{2-[(2,5-二甲基苯氧基)甲基]苯基}-2-甲氧基-N-甲基乙醯胺、(3.027)N-(3-乙基-3,5,5-三甲基環己基)-3-甲醯胺基-2-羥基苯甲醯胺、(3.028)(2E,3Z)-5-{[1-(4-氯-2-氟苯基)-1H-吡唑-3-基]氧}-2-(甲氧基亞胺基)-N，3-二甲基戊-3-烯醯胺。 3) Respiratory chain inhibitors of complex III, for example: (3.001) acetoctradin, (3.002) amisulbrom, (3.003) azoxystrobin, (3.004) carbaryl Ester (coumethoxystrobin), (3.005) coumoxystrobin, (3.006) cyazofamid, (3.007) dimoxystrobin, (3.008) enoxastrobin, (3.009) fen Famoxadon, (3.010) fenamidon, (3.011) flufenoxystrobin, (3.012) fluoxastrobin, (3.013) methylsoxim-methyl , (3.014) methotrexate (metominostrobin), (3.015) anthracycline (orysastrobin), (3.016) picoxystrobin, (3.017) pyraclostrobin (pyracostrobin), (3.018) azole Pyromtostrobin, (3.019) pyraoxystrobin, (3.020) trifloxystrobin, (3.021) (2E)-2-{2-[({[(1E)-1-(3-) {[(E)-1-Fluoro-2-phenylvinyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N -methylacetamide, (3.022)(2E,3Z)-5-{[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}-2-(methoxyimine Base)-N,3 - dimethyl pent-3-enylamine, (3.023) (2R)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy- N-methylacetamide, (3.024) (2S)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methyl Acetamine, (3.025) (3S, 6S, 7R, 8R)-8-benzyl-3-[({3-[(isobutylguanidino)oxy)-4-methoxypyridine-2- (carbonyl)amino]-6-methyl-4,9-di-oxy-1,5-dioxan-7-yl 2-methylpropionate, (3.026) 2-{ 2-[(2,5-Dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide, (3.027) N-(3-ethyl-3,5 ,5-trimethylcyclohexyl)-3-carboxamido-2-hydroxybenzamide, (3.028)(2E,3Z)-5-{[1-(4-chloro-2-fluorophenyl) -1H-pyrazol-3-yl]oxy}-2-(methoxyimino)-N,3-dimethylpent-3-enylamine.

4)有絲分裂與細胞分化之抑制劑，例如：(4.001)卡苯辛(carbendazim)、(4.002)地吩卡(diethofencarb)、(4.003)噻唑菌胺(ethaboxam)、(4.004)氟吡菌胺(fluopicolid)、(4.005)賓克隆(pencycuron)、(4.006)腐絕(thiabendazole)、(4.007)甲基多保淨(thiophanate-methyl)、(4.008)索醯胺(zoxamide)、(4.009)3-氯-4-(2,6-二氟苯基)-6-甲基-5-苯基嗒、(4.010)3-氯-5-(4-氯苯基)-4-(2,6-二氟苯基)-6-甲基嗒、(4.011)3-氯-5-(6-氯吡啶-3-基)-6-甲基-4-(2,4,6-三氟苯基)嗒、(4.012)4-(2-溴-4-氟苯基)-N-(2,6-二氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.013)4-(2-溴-4-氟苯基)-N-(2-溴-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.014)4-(2-溴-4-氟苯基)-N-(2-溴苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.015)4-(2-溴-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.016)4-(2-溴-4-氟苯基)-N-(2-氯苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.017)4-(2-溴-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.018)4-(2-氯-4-氟苯基)-N-(2,6-二氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.019)4-(2-氯-4-氟苯基)-N-(2-氯-6-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.020)4-(2-氯-4-氟苯基)-N-(2-氯苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.021)4-(2-氯-4-氟苯基)-N-(2-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.022)4-(4-氯苯基)-5-(2,6-二氟苯基)-3,6-二甲基嗒、(4.023)N-(2-溴-6-氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺、(4.024)N-(2-溴苯基)-4-(2-氯-4-氟苯 基)-1,3-二甲基-1H-吡唑-5-胺、(4.025)N-(4-氯-2,6-二氟苯基)-4-(2-氯-4-氟苯基)-1,3-二甲基-1H-吡唑-5-胺。 4) Inhibitors of mitosis and cell differentiation, for example: (4.001) carbendazim, (4.002) diehofencarb, (4.003) ethaboxam, (4.004) fluopyram ( Fluopicolid), (4.005) pencycuron, (4.006) thiabendazole, (4.007) thiophanate-methyl, (4.008) zoxamide, (4.009) 3- Chloro-4-(2,6-difluorophenyl)-6-methyl-5-phenylindole , (4.010) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylindole , (4.011) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)anthracene (4.012) 4-(2-Bromo-4-fluorophenyl)-N-(2,6-difluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.013 4-(2-Bromo-4-fluorophenyl)-N-(2-bromo-6-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.014)4 -(2-bromo-4-fluorophenyl)-N-(2-bromophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.015) 4-(2-bromo- 4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.016) 4-(2-bromo-4- Fluorophenyl)-N-(2-chlorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.017) 4-(2-bromo-4-fluorophenyl)-N -(2-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.018) 4-(2-chloro-4-fluorophenyl)-N-(2,6- Difluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.019) 4-(2-chloro-4-fluorophenyl)-N-(2-chloro-6-fluoro Phenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.020) 4-(2-chloro-4-fluorophenyl)-N-(2-chlorophenyl)-1, 3-dimethyl-1H-pyrazole-5-amine, (4.021) 4-(2-chloro-4-fluorophenyl)-N-(2-fluorophenyl)-1,3-dimethyl- 1H-pyrazole-5-amine, (4.022) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylhydrazine , (4.023) N-(2-bromo-6-fluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, ( 4.024) N-(2-Bromophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine, (4.025) N-(4 -Chloro-2,6-difluorophenyl)-4-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-5-amine.

5)具有多重位點活性容量之化合物，例如：(5.001)波爾多(Bordeaux)混合物、(5.002)四氯丹(captafol)、(5.003)蓋普丹(captan)、(5.004)四氯異苯腈(chlorthalonil)、(5.005)氫氧化銅、(5.006)萘甲酸銅、(5.007)氧化銅、(5.008)鹼性氯氧化銅、(5.009)硫酸銅(2+)、(5.010)腈硫醌(dithianon)、(5.011)多寧(dodin)、(5.012)福爾培(folpet)、(5.013)錳粉克(mancozeb)、(5.014)錳乃浦(maneb)、(5.015)滅得賴(metiram)、(5.016)滅得賴鋅鹽(zinc metiram)、(5.017)快得寧(copper oxine)、(5.018)甲基鋅乃浦(propineb)、(5.019)硫與硫製劑，包括：多硫化鈣、(5.020)得恩地(thiram)、(5.021)鋅乃浦(zineb)、(5.022)益穗(ziram)、(5.O23)6-乙基-5,7-二側氧基-6,7-二氫-5H-吡咯并[3',4'：5,6][1,4]二硫雜環己烯并[2,3-c][1,2]噻唑-3-甲腈。 5) Compounds having multiple site activity capacities, for example: (5.001) Bordeaux mixture, (5.002) captafol, (5.003) captan, (5.004) tetrachloroisophthalonitrile (chlorthalonil), (5.005) copper hydroxide, (5.006) copper naphthoate, (5.007) copper oxide, (5.008) alkaline copper oxychloride, (5.009) copper sulfate (2+), (5.010) nitrile sulphide ( Dithianon), (5.011) dodin, (5.012) folpet, (5.013) manganese powder (mancozeb), (5.014) manganese peri (maneb), (5.015) annihilation (metiram ), (5.016) zinc metiram, (5.017) copper oxine, (5.018) methyl zinc flu (propineb), (5.019) sulfur and sulfur preparations, including: polysulfide Calcium, (5.020) thiram, (5.021) zinc nai (zineb), (5.022) zymite (ziram), (5.O23) 6-ethyl-5,7-di- oxy-6 ,7-Dihydro-5H-pyrrolo[3',4':5,6][1,4]dithiahexylene[2,3-c][1,2]thiazole-3-methyl Nitrile.

6)可啟動宿主防衛性之化合物，例如：(6.01)阿拉酸式苯(acibenzolar)-S-甲基、(6.002)異噻菌胺(isotianil)、(6.003)撲殺熱(probenazole)、(6.004)地得尼(tiadinil)。 6) Compounds capable of initiating host defense, such as: (6.01) acibenzolar-S-methyl, (6.002) isotianil, (6.003) probenazole, (6.004) ) tiadinil.

7)胺基酸與/或蛋白質生合成抑制劑，例如：(7.001)嘧菌環胺(cyprodinil)、(7.002)賜黴素(kasugamycin)、(7.003)賜黴素鹽酸鹽水合物、(7.004)土黴素(oxytetracycline)、(7.005)比坦尼(pyrimethanil)、(7.006)3-(5-氟-3,3,4,4-四甲基-3,4-二氫異喹啉-1-基)喹啉。 7) Amino acid and/or protein biosynthesis inhibitors, for example: (7.001) cyprodinil, (7.002) kasugamycin, (7.003) gibberellin hydrochloride hydrate, (7.004) Oxytetracycline, (7.005) pyridone (pyrimethanil), (7.006) 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinoline- 1-yl)quinoline.

8)ATP生產抑制劑，例如：(8.001)矽硫吩(silthiofam)。 8) ATP production inhibitors, for example: (8.001) silthiofam.

9)細胞壁合成抑制劑，例如：(9.001)苯賽卡(benthiavalicarb)、(9.002)地滅莫(dimethomorph)、(9.003)伏莫(flumorph)、(9.004)抑發利(iprovalicarb)、(9.005)曼普胺(mandipropamid)、(9.006)丁吡嗎啉(pyrimorph)、(9.007)發利列(valifenalate)、(9.008)(2E)-3-(4-第三丁基苯基)-3-(2-氯吡啶-4-基)-1-(嗎啉-4-基)丙-2-烯-1-酮、(9.009)(2Z)-3-(4-第三丁基苯基)-3-(2-氯吡啶-4-基)-1-(嗎啉-4-基)丙-2-烯-1-酮。 9) Cell wall synthesis inhibitors, for example: (9.001) benthiavalicarb, (9.002) dimethomorph, (9.003) flumorph, (9.004) iprovalicarb, (9.005) Mandipropamid, (9.006) pyrimorph, (9.007) valifenalate, (9.008) (2E)-3-(4-t-butylphenyl)-3 -(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one, (9.009) (2Z)-3-(4-tert-butylphenyl --3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one.

10)脂質與膜合成抑制劑，例如：(10.001)普莫卡(propamocarb)、(10.002)普莫卡鹽酸鹽、(10.003)特克斯-甲基(tolclofos-methyl)。 10) Lipid and membrane synthesis inhibitors, for example: (10.001) propamocarb, (10.002) pemoca hydrochloride, (10.003) tolclofos-methyl.

11)黑色素生合成抑制劑，例如：(11.001)三賽唑(tricyclazole)、(11.002) {3-甲基-1-[(4-甲基苯甲醯基)胺基]丁-2-基}胺甲酸2,2,2-三氟乙基酯。 11) Melanin synthesis inhibitor, for example: (11.001) tricyclazole, (11.002) {3-methyl-1-[(4-methylbenzylidene)amino]butan-2-yl } 2,2,2-trifluoroethyl carbamate.

12)核酸合成抑制劑，例如：(12.001)本達樂(benalaxyl)、(12.002)本達樂-M(benalaxyl-M)(克拉利(kiralaxyl))、(12.003)滅達樂(metalaxyl)、(12.004)滅達樂-M(metalaxyl-M)(滅芬散(mefenoxam))。 12) Inhibitors of nucleic acid synthesis, for example: (12.001) benalaxyl, (12.002) benalaxyl-M (kiralaxyl), (12.003) metalaxyl, (12.004) Metalaxyl-M (mefenoxam).

13)訊號轉導抑制劑，例如：(13.001)護汰寧(fludioxonil)、(13.002)依普同(iprodione)、(13.003)撲滅寧(procymidone)、(13.004)丙氧喹啉(proquinazid)、(13.005)快諾芬(quinoxyfen)、(13.006)免克寧(vinclozolin)。 13) Signal transduction inhibitors, for example: (13.001) fludioxonil, (13.002) iprodione, (13.003) procymidone, (13.004) propoxyquinoline (proquinazid), (13.005) quinoxyfen, (13.006) vinclozolin.

14)可作為去偶合劑之化合物，例如：(14.001)扶吉胺(fluazinam)、(14.002)敵蟎普(meptyldinocap)。 14) A compound which can be used as a decoupling agent, for example: (14.001) fluazinam, (14.002) meptyldinocap.

15)其他化合物，例如：(15.001)離層酸、(15.002)本噻唑(benthizole)、(15.003)苯(bethoxazine)、(15.004)卡普黴素(capsimycin)、(15.005)卡吩(carvone)、(15.006)喹啉甲硫胺酸鹽(chinomethionat)、(15.007)庫發尼(cufraneb)、(15.008)賽伏醯胺(cyflufenamid)、(15.009)西莫尼(cymoxanil)、(15.010)環丙磺草胺(cyprosulfamide)、(15.011)噻菌淨(flutianil)、(15.012)福賽得鋁(fosetyl-aluminium)、(15.013)福賽得鈣(fosetyl-calcium)、(15.014)福賽得鈉(fosetyl-sodium)、(15.015)異硫氰酸甲酯、(15.016)滅奇吩(metrafenone)、(15.017)米德黴素(mildiomycin)、(15.018)納坦黴素(natamycin)、(15.019)二甲基二硫代胺甲酸鎳、(15.020)硝基太(nitrothal)-異丙基、(15.021)歐賽保(oxamocarb)、(15.022)氧硫普靈(oxathiapiproline)、(15.023)歐芬汀(oxyfenthiin)、(15.024)五氯酚與鹽類、(15.025)膦酸與其鹽類、(15.026)霜黴威乙膦酸鹽(propamocarb-fosetylate)、(15.027)必伏農(pyriofenone)(克吩農(chlazafenon))、(15.028)特伏克(tebufloquin)、(15.029)特伏爛(tecloftalam)、(15.030)特利吩(tolnifanide)、(15.031)1-(4-{4-[(5R)-5-(2,6-二氟苯基)-4,5-二氫-1,2-唑-3-基]-1,3-噻唑-2-基}哌啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮、(15.032)1-(4-{4-[(5S)-5-(2,6-二氟苯基)-4,5-二氫-1,2-唑-3-基]-1,3-噻唑-2-基}哌啶-1-基)-2-[5-甲基-3-(三氟甲基)-1H-吡唑-1-基]乙酮、(15.033)2-(6-苯甲基吡啶-2-基)喹唑啉、(15.034)2,6-二甲基-1H,5H-[1,4]二硫雜環己烯并[2,3-c：5,6-c']二吡咯 -1,3,5,7(2H,6H)-四酮、(15.035)2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-(丙-2-炔-1-基氧)苯基]-4,5-二氫-1,2-唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.036)2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氯-6-(丙-2-炔-1-基氧)苯基]-4,5-二氫-1,2-唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.037)2-[3,5-雙(二氟甲基)-1H-吡唑-1-基]-1-[4-(4-{5-[2-氟-6-(丙-2-炔-1-基氧)苯基]-4,5-二氫-1,2-唑-3-基}-1,3-噻唑-2-基)哌啶-1-基]乙酮、(15.038)2-[6-(3-氟-4-甲氧基苯基)-5-甲基吡啶-2-基]喹唑啉、(15.039)甲磺酸2-{(5R)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-唑-5-基}-3-氯苯基酯、(15.040)甲磺酸2-{(5S)-3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-唑-5-基}-3-氯苯基酯、(15.041)2-{2-[(7,8-二氟-2-甲基喹啉-3-基)氧]-6-氟苯基}丙-2-醇、(15.042)2-{2-氟-6-[(8-氟-2-甲基喹啉-3-基)氧]苯基}丙-2-醇、(15.043)甲磺酸2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-唑-5-基}-3-氯苯基酯、(15.044)甲磺酸2-{3-[2-(1-{[3,5-雙(二氟甲基)-1H-吡唑-1-基]乙醯基}哌啶-4-基)-1,3-噻唑-4-基]-4,5-二氫-1,2-唑-5-基}苯基酯、(15.045)2-苯基酚與其鹽類、(15.046)3-(4,4,5-三氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉、(15.047)3-(4,4-二氟-3,3-二甲基-3,4-二氫異喹啉-1-基)喹啉、(15.048)4-胺基-5-氟嘧啶-2-醇(互變異構形：4-胺基-5-氟嘧啶-2(1H)-酮)、(15.049)4-側氧基-4-[(2-苯基乙基)胺基]丁酸、(15.050)5-胺基-1,3,4-噻二唑-2-硫醇、(15.051)5-氯-N'-苯基-N'-(丙-2-炔-1-基)噻吩-2-亞硫羧基醯肼、(15.052)5-氟-2-[(4-氟苯甲基)氧]嘧啶-4-胺、(15.053)5-氟-2-[(4-甲基苯甲基)氧]嘧啶-4-胺、(15.054)9-氟-2,2-二甲基-5-(喹啉-3-基)-2,3-二氫-1,4-苯并氧氮雜環庚烷、(15.055){6-[({[(Z)-(1-甲基-1H-四唑-5-基)(苯基)亞甲基]胺基}氧)甲基]吡啶-2-基}胺甲酸丁-3-炔-1-基酯、(15.056)(2Z)-3-胺基-2-氰基-3-苯基丙烯酸乙酯、(15.057)吩-1-羧酸、(15.058)3,4,5-三羥基苯甲酸丙酯、(15.059)喹啉-8-醇、(15.060)喹啉-8-醇硫酸鹽(2：1)、(15.061){6-[({[(1-甲基-1H-四唑-5-基)(苯基)亞甲基]胺基}氧)甲基]吡啶-2-基}胺甲酸第三丁酯、(15.062)5-氟-4-亞胺基 -3-甲基-1-[(4-甲基苯基)磺醯基]-3,4-二氫嘧啶-2(1H)-酮。 15) Other compounds, for example: (15.001) lytic acid, (15.002) benzothiazole (benthizole), (15.003) benzene (bethoxazine), (15.004) cappmycin (capsimycin), (15.005) carvone, (15.006) quinoline thioacetate (chinomethionat), (15.007) cufraneb, (15.008) ) cyflufenamid, (15.009) cymoxanil, (15.010) cyprosulfamide, (15.011) flutianil, (15.012) fossil (fosetyl) -aluminium), (15.013) fosetyl-calcium, (15.014) fosetyl-sodium, (15.015) methyl isothiocyanate, (15.016) metrafenone, (15.017) mildiomycin, (15.018) natamycin, (15.019) nickel dimethyldithiocarbamate, (15.020) nitrothal-isopropyl, 15.021) oxamocarb, (15.022) oxathiapiproline, (15.023) oxyfenthiin, (15.024) pentachlorophenol and salts, (15.025) phosphonic acid and its salts, ( 15.026) propamocarb-fosetylate, (15.027) pyrofenone (chlazafenon), (15.028) tebufloquin, (15.029) Tecloftalam), (15.030) Trinity (tolnifani De), (15.031) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2- Zyrid-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl Ethyl ketone, (15.032) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2- Zyrid-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl Ethyl ketone, (15.033) 2-(6-benzylpyridin-2-yl)quinazoline, (15.034) 2,6-dimethyl-1H,5H-[1,4]dithiocyclohexane Alkeno[2,3-c:5,6-c']dipyrrole-1,3,5,7(2H,6H)-tetraone, (15.035)2-[3,5-bis(difluoromethyl) -1H-pyrazol-1-yl]-1-[4-(4-{5-[2-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro- 1,2- Zyrid-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.036) 2-[3,5-bis(difluoromethyl)-1H-pyrazole- 1-yl]-1-[4-(4-{5-[2-chloro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2- Zyrid-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.037) 2-[3,5-bis(difluoromethyl)-1H-pyrazole- 1-yl]-1-[4-(4-{5-[2-fluoro-6-(prop-2-yn-1-yloxy)phenyl]-4,5-dihydro-1,2- Zyrid-3-yl}-1,3-thiazol-2-yl)piperidin-1-yl]ethanone, (15.038) 2-[6-(3-fluoro-4-methoxyphenyl)-5 -methylpyridin-2-yl]quinazoline, (15.039) 2-{(5R)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H-) Pyrazol-1-yl]ethenyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2- Zyrid-5-yl}-3-chlorophenyl ester, (15.040) 2-{(5S)-3-[2-(1-{[3,5-bis(difluoromethyl)-1H) methanesulfonate -pyrazol-1-yl]ethenyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2- Zyrid-5-yl}-3-chlorophenyl ester, (15.041) 2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl }propan-2-ol, (15.042) 2-{2-fluoro-6-[(8-fluoro-2-methylquinolin-3-yl)oxy]phenyl}propan-2-ol, (15.043) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazol-1-yl]ethenyl}piperidin-4-yl)-1 methanesulfonate ,3-thiazol-4-yl]-4,5-dihydro-1,2- Zyrid-5-yl}-3-chlorophenyl ester, (15.044) 2-{3-[2-(1-{[3,5-bis(difluoromethyl)-1H-pyrazole- 1-yl]ethinyl}piperidin-4-yl)-1,3-thiazol-4-yl]-4,5-dihydro-1,2- Oxazol-5-yl}phenyl ester, (15.045) 2-phenylphenol and its salts, (15.046) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-di Hydrogen isoquinolin-1-yl)quinoline, (15.047) 3-(4,4-difluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline, (15.048) 4-Amino-5-fluoropyrimidin-2-ol (tautomeric form: 4-amino-5-fluoropyrimidine-2(1H)-one), (15.049) 4-sided oxy-4 -[(2-phenylethyl)amino]butyric acid, (15.050) 5-amino-1,3,4-thiadiazole-2-thiol, (15.051) 5-chloro-N'-benzene -N'-(prop-2-yn-1-yl)thiophene-2-sulfinylcarboxyl, (15.052) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidine-4- Amine, (15.053) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidine-4-amine, (15.054) 9-fluoro-2,2-dimethyl-5-(quinoline- 3-yl)-2,3-dihydro-1,4-benzoxazepine, (15.055) {6-[({[(Z)-(1-methyl-1H-tetrazole-) 5-yl)(phenyl)methylene]amino}oxy}methyl]pyridin-2-yl}aminecarboxylic acid,but-3-yn-1-yl, (15.056)(2Z)-3-amino Ethyl 2-cyano-3-phenylacrylate, (15.057) phen 1-carboxylic acid, (15.058) propyl 3,4,5-trihydroxybenzoate, (15.059) quinoline-8-ol, (15.060) quinoline-8-ol sulfate (2:1), ( 15.061) {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}aminecarboxylic acid third Butyl ester, (15.062) 5-fluoro-4-imino-3-methyl-1-[(4-methylphenyl)sulfonyl]-3,4-dihydropyrimidin-2(1H)- ketone.

作為混合組份之生物性殺害蟲劑Biological insecticide as a mixed component

式(I)化合物可與生物性殺害蟲劑組合。 The compound of formula (I) can be combined with a biological insecticide.

生物性殺害蟲劑特別包括細菌、真菌、酵母、植物抽出物及由微生物形成之產物，包括蛋白質與二次代謝物。 Biological insecticides include, in particular, bacteria, fungi, yeast, plant extracts, and products formed by microorganisms, including proteins and secondary metabolites.

生物性殺害蟲劑包括細菌，如：形成孢子之細菌、定殖在根部之細菌及具有生物性殺昆蟲劑、殺真菌劑或殺線蟲劑作用之細菌。 Biological insecticides include bacteria such as bacteria that form spores, bacteria that colonize the roots, and bacteria that have biological insecticides, fungicides, or nematicides.

此等已用為或可用為生物性殺害蟲劑之細菌實例為：液化澱粉芽孢桿菌(Bacillus amyloliquefaciens)菌株FZB42(DSM 231179)，或仙人掌桿菌(Bacillus cereus)，尤指仙人掌桿菌(B.cereus)菌株CNCM I-1562或堅強芽胞桿菌(Bacillus firmus)菌株I-1582(登錄號CNCM I-1582)或短小芽胞桿菌(Bacillus pumilus)，尤指菌株GB34(登錄號ATCC 700814)與菌株QST2808(登錄號NRRL B-30087)，或枯草桿菌(Bacillus subtilis)，尤指菌株GB03(登錄號ATCC SD-1397)，或枯草桿菌(Bacillus subtilis)菌株QST713(登錄號NRRL B-21661)或枯草桿菌(Bacillus subtilis)菌株OST 30002(登錄號NRRL B-50421)、蘇雲金芽孢桿菌(Bacillus thuringiensis)，尤指蘇雲金芽胞桿菌以色列亞種(B.thuringiensis subspecies israelensis)(血清型H-14)，菌株AM65-52(登錄號ATCC 1276)，或蘇雲金芽胞桿菌鮎澤亞種(B.thuringiensis subsp.aizawai)，尤指菌株ABTS-1857(SD-1372)，或蘇雲金芽胞桿菌庫斯塔基亞種(B.thuringiensis subsp.kurstaki)菌株HD-1，或蘇雲金芽胞桿菌殺蟲亞種(B.thuringiensis subsp.tenebrionis)菌株NB 176(SD-5428)、穿刺巴斯德菌(Pasteuria penetrans)、巴斯德菌屬(Pasteuria spp.)(腎形腎狀線蟲(Rotylenchulus reniformis))-PR3(登錄號ATCC SD-5834)、細黃鏈黴菌(Streptomyces microflavus)菌株AQ6121(=QRD 31.013、NRRL B-50550)、鮮黃鏈黴菌(Streptomyces galbus)菌株AQ 6047(登錄號NRRL 30232)。 Examples of such bacteria have the pesticide is used as biological or available as: liquefaction of starch Bacillus (Bacillus amyloliquefaciens) strain FZB42 (DSM 231179), or Bacillus cereus (Bacillus cereus), especially Bacillus cereus (B. cereus) Strain CNCM I-1562 or Bacillus firmus strain I-1582 (accession number CNCM I-1582) or Bacillus pumilus , especially strain GB34 (accession number ATCC 700814) and strain QST2808 (accession number) NRRL B-30087), or Bacillus subtilis , especially strain GB03 (accession number ATCC SD-1397), or Bacillus subtilis strain QST713 (accession number NRRL B-21661) or Bacillus subtilis ) strain OST 30002 (accession number NRRL B-50421), Bacillus thuringiensis , especially B. thuringiensis subspecies israelensis (serotype H-14), strain AM65-52 (login number ATCC 1276), or Bacillus thuringiensis aizawai (B.thuringiensis subsp.aizawai), especially strain ABTS-1857 (SD-1372) , or Bacillus thuringiensis库斯塔基亚(B.thuringiensis subsp.kurstaki) strain HD-1, or Bacillus thuringiensis subsp Insecticidal (B.thuringiensis subsp. Tenebrionis) strain NB 176 (SD-5428), Pasteurella puncture (Pasteuria penetrans), Bass Pasteuria spp. ( Rotylenchulus reniformis ) -PR3 (accession number ATCC SD-5834), Streptomyces microflavus strain AQ6121 (=QRD 31.013, NRRL B-50550) Streptomyces galbus strain AQ 6047 (accession number NRRL 30232).

此等已用為或可用為生物性殺害蟲劑之真菌及酵母實例為：巴氏蠶白僵菌(Beauveria bassiana)，尤指菌株ATCC 74040；微坦盾殼黴(Coniothyrium minitans)，尤指菌株CON/M/91-8(登錄號DSM-9660)； 輪枝菌屬(Lecanicillium spp.)，尤指菌株HRO LEC 12；蠟蚧輪枝菌(Lecanicillium lecanii)(過去稱為Verticillium lecanii)，尤指菌株KV01；黑殭菌(Metarhizium anisopliae)，尤指菌株F52(DSM3884/ATCC 90448)；核果梅奇酵母(Metschnikowia fructicola)，尤指菌株NRRL Y-30752；玫煙色擬青黴(Paecilomyces fumosoroseus)(新名稱：玫煙色棒束孢(Isaria fumosorosea))，尤指菌株IFPC 200613，或菌株Apopka 97(登錄號ATCC 20874)；淡紫色擬青黴(Paecilomyces lilacinus)，尤指淡紫色擬青黴(P.lilacinus)菌株251(AGAL 89/030550)；大孢籃狀菌(Talaromyces flavus)，尤指菌株V117b；深綠木黴(Trichoderma atroviride)，尤指菌株SC1(登錄號CBS 122089)；哈茨木黴(Trichoderma harzianum)，尤指哈茨木黴(T.harzianum rifai)T39(登錄號CNCM I-952)。 Examples of such fungi and yeasts that have been or can be used as biological insecticides are: Beauveria bassiana , especially strain ATCC 74040; Coniothyrium minitans , especially strains. CON/M/91-8 (accession number DSM-9660); Lecanicillium spp. , especially strain HRO LEC 12; Lecanicillium lecanii (formerly known as Verticillium lecanii ), especially Refers to strain KV01; Metarhizium anisopliae , especially strain F52 (DSM3884/ATCC 90448); Metschnikowia fructicola , especially strain NRRL Y-30752; Paecilomyces fumosoroseus ( New name: Isaria fumosorosea ), especially strain IFPC 200613, or strain Apopka 97 (accession number ATCC 20874); Paecilomyces lilacinus , especially Paecilomyces lilacinus ( P. Lilacinus ) strain 251 (AGAL 89/030550); Talaromyces flavus , especially strain V117b; Trichoderma atroviride , especially strain SC1 (accession number CBS 122089); Trichoderma harzianum ( Trichoderma harzi Anum ), especially T. harzianum rifai T39 (accession number CNCM I-952).

此等已用為或可用為生物性殺害蟲劑之病毒實例為：棉褐帶卷蛾(Adoxophyes orana)(小食心蟲)顆粒體病毒(GV)、蘋果蠹蛾(Cydia pomonella)顆粒體病毒(GV)、番茄夜蛾(Helicoverpa armigera)(棉蛉蟲)核型多角體病毒(NPV)、甜菜夜蛾(Spodoptera exigua)mNPV、草地斜紋夜蛾(Spodoptera frugiperda)(秋行軍蟲)mNPV、棉貪夜蛾(Spodoptera littoralis)(非洲棉夜蛾)NPVE。 Examples of such viruses that have been or can be used as biological insecticides are: Adoxophyes orana ( Glycyrrhiza granulosus ) granulosis virus (GV), Cydia pomonella granulosis virus (GV) ), Helicoverpa armigera (cotton mites) nuclear polyhedrosis virus (NPV), Spodoptera exigua mNPV, Spodoptera frugiperda (autumn army worm) mNPV, cotton greedy night Moth ( Spodoptera littoralis ) (Aphis gossypii) NPVE.

亦包括以細菌與真菌作為「菌種」加至植物或植株部分或植物器官中，並利用其特殊性質，促進植物生長與植物健康。可述及之實例為：土壤桿菌屬(Agrobacterium spp.)、甘藍固氮根瘤菌(Azorhizobium caulinodans)、固氮螺菌屬(Azospirillum spp.)、固氮菌屬(Azotobacter spp.)、慢生根瘤菌屬(Bradyrhizobium spp.)、伯克氏菌屬(Burkholderia spp.)(尤指洋蔥伯克氏菌(Burkholderia cepacia)(過去稱為洋蔥假單胞菌(Pseudomonas cepacia)))、巨孢球囊黴屬(Gigaspora spp.)或單孢巨孢球囊黴(Gigaspora monosporum)、菌根菌屬(Glomus spp.)、蠟蘑菌屬(Laccaria spp.)、布氏乳桿菌(Lactobacillus buchneri)、類球囊黴屬(Paraglomus spp.)、豆包菌(Pisolithus tinctorus)、假單胞菌屬(Pseudomonas spp.)、根瘤菌屬(Rhizobium spp.)(尤指三葉草根瘤菌(Rhizobium trifolii))、松露屬(Rhizopogon spp.)、硬皮馬勃菌屬 (Scleroderma spp.)、乳牛肝菌屬(Suillus spp.)、鏈黴菌屬(Streptomyces spp.)。 It also includes the addition of bacteria and fungi as "strains" to plants or plant parts or plant organs, and uses its special properties to promote plant growth and plant health. Examples which may be mentioned are: Agrobacterium spp. , Azorhizobium caulinodans , Azospirillum spp. , Azotobacter spp. , and slow-growing Rhizobium ( Bradyrhizobium spp. ), Burkholderia spp. (especially Burkholderia cepacia (formerly known as Pseudomonas cepacia )), genus Corydalis ( Gigaspora spp. ) or Gigaspora monosporum , Glomus spp. , Laccaria spp. , Lactobacillus buchneri , Glomus Genus ( Paraglomus spp. ), Pisolithus tinctorus , Pseudomonas spp. , Rhizobium spp. (especially Rhizobium trifolii ), Rhizopogon spp . ), Scleroderma spp. , Suillus spp. , Streptomyces spp .

已用為或可用為生物性殺害蟲劑之植物抽出物及由微生物形成之產物(包括蛋白質與二次代謝物)實例為：大蒜(Allium sativum)、中亞苦蒿(Artemisia absinthium)、印楝素(azadirachtin)、Biokeeper WP、肉桂(Cassia nigricans)、苦皮藤(Celastrus angulatus)、臭杏(Chenopodium anthelminticum)、幾丁質、Armour-Zen、歐洲鱗毛蕨(Dryopteris filix-mas)、問荊草(Equisetum arvense)、Fortune Aza、Fungastop、Heads Up(藜麥(Chenopodium quinoa)皂苷抽出物)、除蟲菊/除蟲菊酯、苦木(Quassia amara)、櫟屬(Quercus)、皂樹(Quillaja)、虎杖抽出物(Regalia)、「RequiemTM Insecticide」、魚藤酮(rotenone)、魚尼丁(ryania)/雷諾丁(ryanodine)、聚合草(Symphytum officinale)、菊蒿(Tanacetum vulgare)、百里酚、Triact 70、TriCon、金蓮花(Tropaeulum majus)、大蕁麻(Urtica dioica)、藜蘆鹼(Veratrin)、槲寄生(Viscum album)、十字花科抽出物，尤指油菜籽粉或芥末粉。 Examples of plant extracts that have been or can be used as biological insecticides and products formed by microorganisms, including proteins and secondary metabolites, are: Allium sativum, Artemisia absinthium, Neem Azadirachtin, Biokeeper WP, Cassia nigricans, Celastrus angulatus, Chenopodium anthelminticum, chitin, Armour-Zen, Dryopteris filix-mas, phoenix Equisetum arvense, Fortune Aza, Fungastop, Heads Up (Chenopodium quinoa saponin extract), pyrethrum/pyremethrin, Quasisia amara, Quercus, soap tree Quillaja), Regalia, Requiem TM Insecticide, rotenone, ryania/ryanodine, Symphytum officinale, Tanacetum vulgare, 百里Phenol, Triact 70, TriCon, Tropaeulum majus, Urtica dioica, Veratrin, Viscum album, Cruciferous extract, especially rapeseed meal or mustard powder.

作為混合組份之安全劑As a safe component for mixed components

式(I)化合物可與安全劑組合，例如：解草酮(benoxacor)、解毒喹(cloquintocet(-mexyl))、解草胺腈(cyometrinil)、環丙磺草胺(cyprosulfamide)、二氯丙烯胺(dichlormid)、解草唑(fenchlorazole)(-ethyl)、解草啶(fenclorim)、解草安(flurazole)、氟草肟(fluxofenim)、解草唑(furilazole)、雙苯唑酸(isoxadifen(-ethyl))、吡唑解草酯(mefenpyr(-diethyl))、萘甲酸酐、解草腈(oxabetrinil)、2-甲氧基-N-({4-[(甲基胺甲醯基)胺基]苯基}磺醯基)苯甲醯胺(CAS 129531-12-0)、4-(二氯乙醯基)-1-氧雜-4-氮雜螺[4.5]癸烷(CAS 71526-07-3)、2,2,5-三甲基-3-(二氯乙醯基)-1,3-唑啶(CAS 52836-31-4)。 The compound of formula (I) may be combined with a safener, for example: benoxacor, cloquintocet (-mexyl), cyometrinil, cyprosulfamide, dichloropropene Dichlormid, fenchlorazole (-ethyl), fenclorim, flurazole, fluxofenim, turfgrass Furilazole, diphenyl Isozoic acid (isethyldifen (-ethyl)), mefenpyr (-diethyl), naphthalic anhydride, oxabetrinil, 2-methoxy-N-({4-[(methyl) Aminomethyl)amino]phenyl}sulfonyl)benzamide (CAS 129531-12-0), 4-(dichloroethenyl)-1-oxa-4-azaspiro[4.5 ] decane (CAS 71526-07-3), 2,2,5-trimethyl-3-(dichloroethenyl)-1,3- Azole (CAS 52836-31-4).

植物與植株部份Plant and plant parts

所有植物與植株部份均可根據本發明處理。此時，咸瞭解植物係指所有植物及植物族群，如：需要及不需要之野生植物或作物(包括天然作物)，例如：穀類(小麥、稻、硬粒小麥、大麥、裸麥、燕麥)、玉米、大豆、馬鈴薯、甜菜、甘蔗、番茄、甜椒、胡瓜、甜瓜、胡蘿蔔、 西瓜、洋蔥、萵苣、菠菜、大葱、豆類、十字花科蔬菜(Brassica oleracea)(例如：捲心白菜)與其他蔬菜類、棉花、菸草、油菜、與果實植物(蘋果、梨、柑橘類果實與葡萄)。作物可為得自依傳統育種法與最適化方法或利用生物技術與遺傳工程法或此等方法之組合所取得者，包括轉殖基因植物，及包括受植物育種者權益保護或未受保護之植物栽培品種。咸瞭解，植物意指所有發展階段，如：種子、幼苗、幼株(未成熟)、直到且包括成熟植物。應咸瞭解，植株部份意指植物之所有地上及地下部份與器官，如：芽、葉、花與根，其實例可述及：闊葉、針葉、莖、樹幹、花、果實體、果實與種子，及根、球莖、與根莖。植株部份亦包括收成之植物或收成之植株部份，及無性與有性繁殖材料，例如：扦插、球莖、根莖、插枝與種子。 All plant and plant parts can be treated in accordance with the present invention. At this time, the salty plant refers to all plants and plant groups, such as wild plants or crops (including natural crops) that are needed and not needed, for example: cereals (wheat, rice, durum wheat, barley, rye, oats) , corn, soybeans, potatoes, beets, sugar cane, tomatoes, sweet peppers, courgettes, melons, carrots, watermelons, onions, lettuce, spinach, green onions, beans, Brassica oleracea (eg cabbage) and Other vegetables, cotton, tobacco, canola, and fruit plants (apples, pears, citrus fruits and grapes). Crops may be obtained from traditional breeding methods and optimization methods or using biotechnology and genetic engineering methods or combinations of such methods, including genetically modified plants, and including protected or unprotected by plant breeders' rights. Plant cultivars. It is understood that plants mean all stages of development, such as: seeds, seedlings, young plants (immature), up to and including mature plants. It should be understood that plant parts refer to all above-ground and underground parts and organs of plants, such as buds, leaves, flowers and roots. Examples can be described as: broadleaf, needles, stems, trunks, flowers, fruit bodies. , fruits and seeds, and roots, bulbs, and rhizomes. The plant part also includes the harvested plant or harvested plant parts, as well as vegetative and sexually propagated materials such as cuttings, bulbs, rhizomes, cuttings and seeds.

本發明使用式(I)化合物處理植物與植株部份之方法係依習用之處理法直接處理或使化合物作用在其周圍、棲息地或庫存空間，例如：浸泡、噴灑、蒸發、霧化、撒播、塗刷、注射，且若處理繁殖材料時，尤其處理種子時，亦可施加一層或多層包衣。 The method of the present invention for treating plants and plant parts using the compound of formula (I) is directly treated or applied to the surrounding, habitat or stock space by methods such as soaking, spraying, evaporating, atomizing, spreading , brushing, injecting, and if the propagation material is treated, especially when the seed is treated, one or more layers of coating may be applied.

如上述，根據本發明可處理所有植物與其部份植株。較佳具體實施例中係處理野生植物品種與植物栽培品種，或彼等由傳統生物育種法(如：交配法或原生質融合法)取得者，與其部份植株。另一項較佳具體實施例中，係處理由遺傳工程方法(若適當時，可併用傳統方法)得到之轉殖基因植物與植物栽培品種(基因改造生物)，及其部份植株。術語「部份」或「植株部份」或「部份植株」已如上述說明。特別佳者係根據本發明處理自商品取得或使用中之植物栽培品種之植物。咸瞭解，植物栽培品種意指經由傳統育種法、誘變法或重組DNA技術得到之具有新穎性質(「性狀」)之植物。其可為栽培品種、變異種、生物型或基因型。 As mentioned above, all plants and parts of their plants can be treated according to the invention. In a preferred embodiment, wild plant varieties and plant cultivars are treated, or those obtained by conventional biological breeding methods (eg, mating method or protoplast fusion method), and some of the plants. In another preferred embodiment, the transgenic plants and plant cultivars (genetically modified organisms) obtained by genetic engineering methods (and, if appropriate, conventional methods), and parts thereof are treated. The terms "part" or "plant part" or "partial plant" have been described above. Particularly preferred are plants which are treated according to the invention from plant cultivars obtained or used in the art. It is understood that plant cultivars mean plants having novel properties ("traits") obtained by conventional breeding methods, mutagenesis methods or recombinant DNA techniques. It can be a cultivar, a variant, a biotype or a genotype.

轉殖基因植物、種子處理法與整合品項Transgenic plants, seed treatment and integrated items

根據本發明處理之較佳轉殖基因植物或植物栽培品種(彼等由遺傳工程取得者)包括所有透過基因改造過程，接受賦與特別有利性質(「性狀」)之遺傳物質之植物。此等性質實例為改善植物生長、提高對高溫或低溫之耐受性、提高對乾旱或對水含量或土壤鹽含量之耐受性、提 高開花率、簡化收成、加速成熟、提高收成量、提高所收成產品之品質與/或提高營養價值、所收成產品之更佳儲存壽命與/或提高可加工性。其他及特別強調之此等性質實例為提高植物對抗動物害蟲與有害微生物之防禦性，如：由例如：植物內所形成之毒素，特定言之由來自蘇雲金芽孢桿菌(Bacillus thuringiensis)之遺傳物質(例如：基因CryIA(a)、CryIA(b)、CryIA(c)、CryIIA、CryIIIA、CryIIIB2、Cry9c、Cry2Ab、Cry3Bb與CryIF及其組合)於植物中產生之毒素來對抗昆蟲、蜘蛛、線蟲、蟎類、蛞蝓與蝸牛，進一步利用例如：後天取得之全株抗性(SAR)、系統素(systemin)、植物抗毒素(phytoalexins)、誘發素(elicitors)與抗性基因，及相應表現之蛋白質與毒素，提高植物對抗植物病原性真菌、細菌與/或病毒之抗性，亦提高植物對某些除草活性化合物，例如：咪唑啉酮類、磺醯脲類、嘉磷塞(glyphosate)或草銨膦(phosphonotricin)之耐受性(例如：「PAT」基因)。此等賦與所需性質(「性狀」)之基因亦可相互組合進入轉殖基因植物中。可述及之轉殖基因植物實例包括重要作物，如：穀類(小麥、稻、硬粒小麥、大麥、裸麥、燕麥)、玉米、大豆、馬鈴薯、甜菜、甘蔗、番茄、豌豆及其他蔬菜品種、棉花、菸草、油菜與果實植物(生產蘋果、梨、柑橘類水果與葡萄)，特別著重於玉米、大豆、小麥、稻、馬鈴薯、棉花、甘蔗、番茄與油菜。特別強調之性質(「性狀」)為提高植物對抗昆蟲、蜘蛛、線蟲、蛞蝓與蝸牛之抗性。 Preferred transgenic plants or plant cultivars (which are acquired by genetic engineering) treated in accordance with the present invention include all plants that receive genetic material that confers a particularly advantageous property ("trait") through a genetic modification process. Examples of such properties are to improve plant growth, increase tolerance to high or low temperatures, increase tolerance to drought or water content or soil salt content, increase flowering rate, simplify harvest, accelerate ripening, increase harvest, and increase The quality of the harvested product and/or improved nutritional value, better shelf life of the harvested product and/or improved processability. Other and particularly emphasized examples of such properties are the enhancement of the defensiveness of plants against animal pests and harmful microorganisms, such as, for example, toxins formed in plants, in particular by genetic material from Bacillus thuringiensis ( For example: the genes CryIA (a), CryIA (b), CryIA (c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF and combinations thereof to produce toxins in plants against insects, spiders, nematodes, cockroaches Classes, mites and snails, further utilizing, for example, acquired plant resistance (SAR), systemin, phytoalexins, elicitors and resistance genes, and corresponding proteins and toxins To increase the resistance of plants against phytopathogenic fungi, bacteria and/or viruses, and to increase certain herbicidal active compounds, such as imidazolinones, sulfonylureas, glyphosate or glufosinate. Tolerance of (phosphonotricin) (eg, "PAT" gene). These genes, which confer the desired properties ("traits"), can also be combined into a transgenic plant. Examples of transgenic plants that can be mentioned include important crops such as cereals (wheat, rice, durum wheat, barley, rye, oats), corn, soybeans, potatoes, beets, sugar cane, tomatoes, peas and other vegetable varieties. , cotton, tobacco, canola and fruit plants (production of apples, pears, citrus fruits and grapes), with particular emphasis on corn, soybeans, wheat, rice, potatoes, cotton, sugar cane, tomatoes and canola. Special emphasis on the nature ("traits") is to increase the resistance of plants to insects, spiders, nematodes, mites and snails.

作物保護法-處理型態Crop Protection Law - Treatment Type

使用式(I)化合物處理植物與植株部份時，係採用習知處理法直接處理或作用在其周圍、棲息地或庫存空間，例如：浸泡、噴灑、噴霧、灌注、蒸發、撒粉、霧化、撒播、起泡、塗刷、散播、注射、澆水(澆淋)、滴灌，若處理繁殖材料時，特定言之處理種子時，亦可採用乾式種子處理法、液體種子處理法、漿式處理法、包殼、塗佈一層或多層包衣，等等。亦可進一步採用超低體積法施用式(I)化合物或取施用型式或式(I)化合物本身注射至土壤中。 When the plant and plant parts are treated with the compound of formula (I), they are directly treated or applied to the surrounding, habitat or stock space by conventional treatment methods, such as: soaking, spraying, spraying, pouring, evaporating, dusting, fogging. Dissolving, spreading, foaming, painting, spreading, injecting, watering (pouring), drip irrigation, if the seed is treated, when it is treated with specific seeds, dry seed treatment, liquid seed treatment, pulp Process, encapsulation, coating one or more layers of coating, and the like. The compound of formula (I) may also be further applied by ultra low volume method or by injection of the compound of formula or formula (I) into the soil.

植物之較佳直接處理法為葉部施用法，亦即讓式(I)化合物施用在葉部，其中處理頻率及施用率應配合所針對害蟲之感染程度來調整。若為全株作用性活性成份時，式(I)化合物亦可經由根系到達植物。因 此可由式(I)化合物作用在植物所在地來處理植物。其作法可為例如：浸泡或混合至土壤或營養液中，亦即在植物所在地(例如：土壤或水耕系統)浸入液體型式之式(I)化合物，或藉由土壤施用法，亦即將式(I)化合物以固體型式(例如：呈粒劑型式)加至植物所在地。若為水稻作物時，其作法為量取式(I)化合物固體施用型式(例如：粒劑)加至水稻田中。 A preferred direct treatment of plants is the foliar application method, i.e., the compound of formula (I) is applied to the leaves, wherein the frequency of treatment and the rate of application are adjusted to match the degree of infection of the pest in question. In the case of a whole plant active ingredient, the compound of formula (I) can also reach the plant via the root system. The plant can therefore be treated by the action of a compound of formula (I) at the locus of the plant. The method can be, for example, immersion or mixing into soil or nutrient solution, that is, immersing in the liquid form of the compound of formula (I) at the plant site (for example, soil or hydroponic system), or by soil application method, (I) The compound is added to the locus of the plant in a solid form (for example, in the form of a granule). In the case of a rice crop, the method is to measure the solid application form of the compound of formula (I) (for example, granules) and add it to the paddy field.

種子處理法Seed treatment

長久以來已知藉由處理植物種子來控制動物害蟲且仍在改良中。然而，處理種子時，經常出現一些無法以令人滿意之方式解決之問題。因此需要發展一種保護種子及發芽植物之方法，其可以在儲存期間、播種後或植物發芽後免除或至少顯著減少另外施用殺害蟲劑。亦需要使活性成份以最適當用量提供種子及發芽植物最佳保護程度，以免動物害蟲侵害，但不讓所使用活性成份傷害植物本身。特定言之，處理種子之方法亦應考量可抵抗或耐受害蟲之轉殖基因植物固有之殺昆蟲或殺線蟲性質，以便在最低之殺害蟲劑用量下，對種子及發芽植物達最佳保護程度。 It has long been known to control animal pests by treating plant seeds and still in the process of improvement. However, when dealing with seeds, there are often problems that cannot be solved in a satisfactory manner. There is therefore a need to develop a method of protecting seeds and germinating plants which can be used to eliminate or at least significantly reduce the additional application of insecticidal agents during storage, after sowing or after germination of the plants. It is also necessary to provide the active ingredients with optimum protection of the seeds and germinating plants in an optimum amount to avoid animal pests, but not to use the active ingredients to harm the plants themselves. In particular, the method of seed treatment should also consider the insecticidal or nematicidal properties inherent in plants that are resistant or resistant to pests, so as to provide optimal protection for seeds and germinating plants at the lowest level of pesticide use. degree.

本發明因此特定言之，亦有關使用一種式(I)化合物處理種子，以保護種子與發芽植物免於害蟲侵害之方法。根據本發明保護種子與發芽植物對抗害蟲侵害之方法亦包括以式(I)化合物與混合組份在一次操作中同時處理或依序處理之方法。亦包括以式(I)化合物與混合組份在不同時間處理種子之方法。 The invention thus specifically relates to a method of treating seeds with a compound of formula (I) to protect the seed from the germinating plant from pests. The method for protecting a seed from a germinating plant against pests according to the present invention also comprises a method of simultaneously treating or sequentially treating the compound of the formula (I) with the mixed component in one operation. Also included are methods of treating seeds with the compound of formula (I) and the mixed components at different times.

本發明同樣係有關一種以式(I)化合物於處理種子上之用途，以保護種子與所長成植物免於動物害蟲侵害。 The invention is also related to the use of a compound of formula (I) for treating seed to protect the seed from the grown plant from animal pests.

本發明進一步有關一種已經過根據本發明式(I)化合物處理之種子，以保護免於動物害蟲侵害。本發明亦有關一種經過式(I)化合物與混合組份同時處理之種子。本發明亦有關一種經過式(I)化合物與混合組份在不同時間點處理之種子。若為經過式(I)化合物與混合組份在不同時間點處理之種子時，該等個別物質可存在於種子之不同覆層中。此時，包含式(I)化合物之覆層與包含混合組份之覆層可視需要利用中間層分隔。本發明亦有關一種已經過式(I)化合物與混合組份作為包衣之一部份或作為包衣以外之另一層或多層塗覆之種子。 The invention further relates to a seed which has been treated according to the compound of formula (I) according to the invention to protect against animal pests. The invention also relates to a seed which is treated simultaneously with a compound of formula (I) and a mixed component. The invention also relates to a seed treated at a different point in time via a compound of formula (I) and a mixed component. If the seed of the compound of formula (I) and the mixed component are treated at different time points, the individual substances may be present in different coatings of the seed. In this case, the coating comprising the compound of formula (I) and the coating comprising the mixed component may optionally be separated by an intermediate layer. The invention also relates to a seed which has been subjected to the compound of formula (I) and the mixed component as part of the coating or as another layer or layers coated other than the coating.

本發明進一步有關一種種子，其在經過式(I)化合物處理後，再經過包膜衣製程，以防止種子被塵粉磨損。 The invention further relates to a seed which, after being treated with a compound of formula (I), is subjected to a coating process to prevent the seed from being worn by the dust.

當式(I)化合物具全株作用性時，其優點之一在於經過處理之種子不僅可保護種子本身，而且可保護種子出土後所長成植株，對抗動物害蟲侵害。依此方式，即不需要在播種期間或播種後短時間內立即處理作物。 When the compound of the formula (I) has a whole plant activity, one of the advantages is that the treated seed not only protects the seed itself, but also protects the seed from growing into a plant after the seed is unearthed, and is resistant to animal pests. In this way, it is not necessary to treat the crop immediately during sowing or shortly after sowing.

另一項優點在於透過式(I)化合物處理種子，可促進該經過處理之種子發芽及出土。 Another advantage is that the treatment of the seed through the compound of formula (I) promotes germination and emergence of the treated seed.

同樣可視為優點之處在於式(I)化合物亦可特別用於轉殖基因種子。 It can also be considered to be advantageous in that the compounds of the formula (I) can also be used in particular for the transfer of genetic seeds.

此外，式(I)化合物亦可與訊號轉導技術組成物組合使用，結果可以改善與共生菌(如，例如：根瘤菌、菌根菌與/或內生細菌或真菌)之定殖，及/或達最佳固氮作用。 In addition, the compounds of formula (I) can also be used in combination with signal transduction technology compositions to improve colonization with commensal bacteria such as, for example, rhizobium, mycorrhizal and/or endophytic bacteria or fungi, and / or up to the best nitrogen fixation.

式(I)化合物適合保護任何用於農業、溫室、森林或園藝之植物栽培品種之種子。更特定言之，其包括穀類(例如：小麥、大麥、裸麥、燕麥與小米)、玉米、棉花、大豆、稻、馬鈴薯、葵花、咖啡、菸草、芥花、油菜、甜菜(例如：製糖用甜菜與飼料用甜菜)、花生、蔬菜(如：番茄、胡瓜、豆、十字花科蔬菜、洋蔥與萵苣)、果實植物、草皮與觀賞植物之種子。特別重要為處理穀類(如：小麥、大麥、裸麥與燕麥)、玉米、大豆、棉花、芥花、油菜、蔬菜與稻之種子。 The compounds of formula (I) are suitable for protecting any seed of plant cultivars used in agriculture, greenhouses, forests or horticulture. More specifically, it includes cereals (eg, wheat, barley, rye, oats and millet), corn, cotton, soybeans, rice, potatoes, sunflowers, coffee, tobacco, canola, canola, and beets (eg, for sugar production) Beets and fodder beets), peanuts, vegetables (eg tomatoes, courgettes, beans, cruciferous vegetables, onions and lettuce), fruit plants, turf and ornamental plants. Of particular importance is the treatment of cereals (eg wheat, barley, rye and oats), corn, soybeans, cotton, canola, canola, vegetables and rice seeds.

亦如上述，式(I)化合物對轉殖基因種子之處理法亦特別重要。此時涉及之植物種子通常包含至少一種可以控制特定言之具有殺昆蟲性質與/或殺線蟲性質之多肽表現之異源基因。該轉殖基因種子中之此等異源基因可源自下列微生物，如：芽胞桿菌(Bacillus)、根瘤菌(Rhizobium)、假單胞菌(Pseudomonas)、沙雷氏菌(Serratia)、木黴(Trichoderma)、棒形桿菌(Clavibacter)、菌根菌(Glomus)或黏帚黴(Gliocladium)。本發明特別適合處理包含至少一種來自芽胞桿菌屬(Bacillus sp.)之異源基因之轉殖基因種子。更佳為該異源基因係來自蘇雲金芽胞桿菌(Bacillus thuringiensis)。 As also mentioned above, the compounds of formula (I) are also of particular importance for the treatment of genetically engineered seeds. The plant seeds involved at this point typically comprise at least one heterologous gene that can control the expression of a polypeptide having insecticidal properties and/or nematicidal properties in particular. The transfected gene seed colonization of these heterologous genes may be derived from the following organisms, such as: Bacillus (Bacillus), Rhizobium (with Rhizobium), Pseudomonas (of Pseudomonas), Serratia (SERRATIA), Trichoderma ( Trichoderma ), Clavibacter , Glomus or Gliocladium . The invention is particularly suitable for treating seed of a transgenic gene comprising at least one heterologous gene from Bacillus sp . More preferably, the heterologous gene line is derived from Bacillus thuringiensis .

本發明內容中，式(I)化合物係施用至種子上。接受處理之種子最 好處於充份穩定狀態，以免在處理過程中損傷。通常，可在收穫至播種期間任何時間點處理種子。所採用之種子通常已與植株分離且已脫除軸、殼、稈、包衣、穗或果肉。因此例如：可採用已經過採收、清潔且乾燥至可以儲存之水份含量之種子。或者亦可使用乾燥後再例如：經過水處理後再度乾燥之種子，例如：底層處理。處理稻種子時，亦可使用例如：已吸水至稻胚胎特定階段(雞胸型階段)之種子，以刺激發芽及較一致之出土。 In the context of the present invention, the compound of formula (I) is applied to the seed. The seeds to be treated are preferably in a stable state to avoid damage during processing. Typically, the seed can be treated at any point during harvesting to sowing. The seeds used have generally been separated from the plant and have been removed from the shaft, shell, stalk, coating, ear or pulp. Thus, for example, seeds that have been harvested, cleaned and dried to a moisture content that can be stored can be used. Alternatively, it may be used after drying, for example, a seed which has been dried after being treated with water, for example, a bottom treatment. When treating rice seeds, for example, seeds that have been absorbed to a specific stage of the rice embryo (chicken chest stage) can be used to stimulate germination and more consistent emergence.

當處理種子時，通常必需小心選擇施用至種子之式(I)化合物與/或其他添加劑之施用量，以免破壞種子發芽，或不致於傷害所長成之植物。尤其當活性成份在特定施用率下可能具有植物毒性時，必需確保此點。 When treating seeds, it is usually necessary to carefully select the amount of the compound of formula (I) and/or other additives applied to the seed so as not to damage the seed germination or to damage the grown plant. This must be ensured especially when the active ingredient may be phytotoxic at a particular application rate.

通常，式(I)化合物係呈合適調配物施用至種子上。處理種子之合適調配物與方法係習此相關技藝之人士習知者。 Typically, the compound of formula (I) is applied to the seed in a suitable formulation. Suitable formulations and methods for treating seeds are well known to those skilled in the art.

式(I)化合物可轉換成常用拌種調配物，如：溶液、乳液、懸浮液、粉劑、發泡劑、漿物或種子之其他包衣組成物，與ULV調配物。此等調配物可依已知方式製造，混合式(I)化合物與常用之添加劑，例如：常用之增效劑，及溶劑或稀釋劑、染劑、濕化劑、勻散劑、乳化劑、消泡劑、防腐劑、二次增稠劑、膠黏劑、赤黴素，及水。 The compound of formula (I) can be converted to conventional seed dressing formulations such as solutions, emulsions, suspensions, powders, foaming agents, other coating compositions of seeds or seeds, and ULV formulations. These formulations can be prepared in a known manner by mixing the compound of formula (I) with conventional additives such as: commonly used synergists, and solvents or diluents, dyes, wetting agents, leveling agents, emulsifiers, consumer Foaming agents, preservatives, secondary thickeners, adhesives, gibberellins, and water.

根據本發明可使用之拌種調配物中可包含之染劑為此等目的常用之所有染劑。此時，可使用難溶於水之色素，或可使用水溶性染劑。其實例包括彼等已知名稱為若丹明B(Rhodamin B)、C.I.紅色素(Pigment Red)112號與C.I.溶劑紅(Solvent Red)1號之染劑。 The dyes which may be included in the seed dressing formulations which can be used in accordance with the invention are all dyes commonly used for such purposes. At this time, a pigment which is hardly soluble in water may be used, or a water-soluble dye may be used. Examples thereof include those known by the names Rhodamin B, C.I. Pigment Red No. 112 and C.I. Solvent Red No. 1.

根據本發明可使用之拌種調配物中可包含之適用濕化劑為可促進濕化及調配農化活性成份時常用之所有物質。較佳為使用萘磺酸烷基酯類，如：萘磺酸二異丙基酯或-二異丁基酯。 Suitable moisturizing agents which may be included in the seed dressing formulations which can be used in accordance with the invention are all materials which are conventionally used to promote wetting and formulation of agrochemically active ingredients. It is preferred to use alkyl naphthalenesulfonates such as diisopropyl naphthalenesulfonate or di-isobutyl ester.

根據本發明可使用之拌種調配物中可包含之適用勻散劑與/或乳化劑為調配農化活性成份時常用之所有非離子性、陰離子性與陽離子性勻散劑。較佳為使用非離子性或陰離子性勻散劑或非離子性或陰離子性勻散劑之混合物。合適之非離子性勻散劑尤其包括環氧乙烷/氧化丙烯嵌段聚合物、烷基苯酚聚二醇醚與三苯乙烯苯酚聚二醇醚，及其磷酸化 或硫酸化衍生物。合適之陰離子性勻散劑尤其指木質素磺酸鹽、聚丙烯酸鹽與芳基磺酸鹽-甲醛縮合物。 Suitable dispersing agents and/or emulsifiers which may be included in the seed dressing formulations which can be used according to the invention are all nonionic, anionic and cationic dispersing agents which are customary in the formulation of agrochemical active ingredients. It is preferred to use a nonionic or anionic dispersing agent or a mixture of nonionic or anionic dispersing agents. Suitable nonionic dispersing agents include, inter alia, ethylene oxide/propylene oxide block polymers, alkylphenol polyglycol ethers and tristyrylphenol polyglycol ethers, and phosphorylated or sulfated derivatives thereof. Suitable anionic dispersing agents especially refer to lignosulfonates, polyacrylates and arylsulfonate-formaldehyde condensates.

根據本發明可使用之拌種調配物中可包含之消泡劑為調配農化活性成份時常用之所有抑制泡沫物質。較佳為使用聚矽氧消泡劑與硬脂酸鎂。 Defoamers which may be included in the seed dressing formulations which can be used in accordance with the invention are all foam inhibiting substances which are conventionally used in the formulation of agrochemical active ingredients. Preferably, a polyfluorene defoamer and magnesium stearate are used.

根據本發明可使用之拌種調配物中可包含之防腐劑為農化組成物中為了此等目的常用之所有物質。其實例包括二氯吩(dichlorophen)與苯甲醇半縮甲醛。 Preservatives which may be included in the seed dressing formulations which may be employed in accordance with the invention are all materials commonly used in agrochemical compositions for such purposes. Examples thereof include dichlorophen and benzyl alcohol hemiformal.

根據本發明可使用之拌種調配物中可包含之二次增稠劑為農化組成物中為了此等目的常用之所有物質。較佳實例包括：纖維素衍生物、丙烯酸衍生物、黃原膠、改質黏土與高分散性矽石。 Secondary thickeners which may be included in the seed dressing formulations which may be employed in accordance with the invention are all materials commonly used in agrochemical compositions for such purposes. Preferred examples include cellulose derivatives, acrylic acid derivatives, xanthan gum, modified clay and highly dispersible vermiculite.

根據本發明可使用之拌種調配物中可包含之適用膠黏劑為拌種產品中所有常用之結合劑。較佳實例包括聚乙烯基吡咯啶酮、聚乙酸乙烯酯、聚乙烯醇，與纖基乙酸鈉(tylose)。 Suitable adhesives which may be included in the seed dressing formulations which can be used in accordance with the invention are all commonly used binders in the seed dressing product. Preferred examples include polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, and tylose.

根據本發明可使用之拌種調配物中可包含之赤黴素較佳為赤黴素A1、A3(=赤黴酸)、A4與A7；以使用赤黴酸特別佳。該赤黴素係已知者(參見R.Wegler之Chemie der Pflanzenschutz-und Schädlingsbekämpfungsmittel，Vol.2,Springer Verlag,1970,pp.401-412)。 The gibberellins which may be included in the seed dressing formulations which can be used according to the invention are preferably gibberellins A1, A3 (=gibberellic acid), A4 and A7; particularly preferred for the use of gibberellic acid. The gibberellin is known (see Chemie der Pflanzenschutz-und Schädlingsbekämpfungsmittel, Vol. 2, Springer Verlag, 1970, pp. 401-412 by R. Wegler).

根據本發明可使用之拌種調配物可直接使用或加水稀釋後使用，用於處理各種不同種子。例如：該濃縮劑或其加水稀釋後所得之製劑可用於包覆穀類(如：小麥、大麥、裸麥、燕麥與硬粒小麥)之種子，及玉米、稻、油菜、豌豆、豆類、棉花、葵花、大豆及甜菜之種子，或各種不同蔬菜之種子。可根據本發明使用之拌種調配物或其稀釋之施用型式亦可用於包覆轉殖基因植物之種子。 The seed dressing formulations which can be used in accordance with the invention can be used directly or after dilution with water for the treatment of various seeds. For example, the concentrate or its diluted water-added preparation can be used to coat seeds of cereals (eg, wheat, barley, rye, oats, and durum wheat), and corn, rice, canola, peas, beans, cotton, Seeds of sunflower, soybeans and beets, or seeds of various vegetables. Seed dressing formulations which may be used in accordance with the invention or their diluted application forms may also be used to coat seeds of transgenic plants.

根據本發明可使用之拌種調配物或其加水製成之施用型式用於處理種子時，可使用所有常用於拌種之合適混合裝置。明確言之，進行該拌種過程時，將種子置入混合機中，依分批或連續操作方式，添加所需拌種調配物特定用量，可直接添加或先加水稀釋後添加，混合直到調配物均勻分佈在種子上為止。若適當時可接著進行乾燥過程。 When the seed dressing formulation or the water-added application form which can be used according to the invention is used for the treatment of seeds, all suitable mixing devices which are commonly used for seed dressing can be used. Specifically, when the seed dressing process is carried out, the seed is placed in a mixer, and the specific amount of the desired seed dressing is added according to batch or continuous operation, and can be directly added or diluted with water and added, mixed until blending The matter is evenly distributed on the seed. The drying process can then be carried out if appropriate.

根據本發明可使用之拌種調配物之施用率可在相當大範圍內變化。其依據調配物中式(I)化合物之特定含量及依據種子而變化。式(I)化合物之施用率通常在每公斤種子0.001至50克之間，較佳為每公斤種子0.01至15克之間。 The application rate of the seed dressing formulations which can be used in accordance with the invention can vary over a considerable range. It varies depending on the particular amount of the compound of formula (I) in the formulation and on the basis of the seed. The application rate of the compound of the formula (I) is usually between 0.001 and 50 g per kg of seed, preferably between 0.01 and 15 g per kg of seed.

動物健康Animal health

在動物健康領域(亦即獸醫學領域)，式(I)化合物可活性對抗動物寄生蟲，特定言之體外寄生蟲或體內寄生蟲。術語「體內寄生蟲」尤其包括蠕蟲與原蟲，如：球蟲目(Coccidia)。體外寄生蟲通常且較佳為節肢動物，尤指昆蟲或蜱蟎類。 In the field of animal health (ie, the field of veterinary medicine), the compounds of formula (I) are active against animal parasites, in particular ectoparasites or endoparasites. The term "endoparasite" includes, inter alia, helminths and protozoa, such as Coccidia. Extracorporeal parasites are usually and preferably arthropods, especially insects or mites.

在獸醫學領域中，對恆溫動物具有有利毒性之式(I)化合物適合在畜牧、養殖動物、動物園動物、實驗室動物、實驗動物與家畜動物中控制出現在動物養殖及動物畜養中之寄生蟲。其可活性對抗寄生蟲之所有或特定發展階段。 In the field of veterinary medicine, the compound of formula (I) which is advantageously toxic to warm-blooded animals is suitable for controlling parasites present in animal husbandry and animal husbandry in livestock, farm animals, zoo animals, laboratory animals, laboratory animals and livestock animals. . It can be active against all or specific stages of development of the parasite.

農業牲畜包括例如：哺乳動物，如：綿羊、山羊、馬、驢、駱駝、水牛、兔子、馴鹿、黇鹿及尤指牛與豬；或禽類，如：火雞、鴨、鵝，及尤指雞；或魚類或甲殼類，例如：水產養殖，或可能為昆蟲，如：蜜蜂。 Agricultural livestock include, for example, mammals such as sheep, goats, horses, donkeys, camels, buffalos, rabbits, reindeer, elk and especially cattle and pigs; or poultry such as turkeys, ducks, geese, and especially Chicken; or fish or crustaceans, for example: aquaculture, or possibly insects such as bees.

家畜動物包括例如：哺乳動物，如：倉鼠、天竺鼠、大鼠、小鼠、栗鼠、雪貂，及特定言之狗、貓、籠內的鳥、爬蟲類、兩棲類或水族箱內的魚。 Livestock animals include, for example, mammals such as hamsters, guinea pigs, rats, mice, chinchillas, ferrets, and specific dogs, cats, caged birds, reptiles, amphibians, or fish in aquaria.

明確具體實施例中，式(I)化合物係投與哺乳動物。 In a specific embodiment, the compound of formula (I) is administered to a mammal.

另一項明確具體實施例中，式(I)化合物係投與鳥類，亦即籠內的鳥，或尤指禽類。 In another specific embodiment, the compound of formula (I) is administered to a bird, that is, a bird in a cage, or especially a bird.

使用式(I)化合物控制動物寄生蟲，係計畫降低或防止生病、死亡例及下降之效能(指肉品、乳品、毛、皮、蛋、蜂蜜，等等)，因此可以達到更經濟及更簡單之動物管理及更佳之動物效益。 The use of a compound of formula (I) to control animal parasites is intended to reduce or prevent the onset of illness, death and decline (referred to as meat, dairy, wool, hide, egg, honey, etc.), thereby achieving a more economical Simpler animal management and better animal benefits.

在動物健康之相關領域中，術語「控制」或「防治」係指式(I)化合物可有效降低特定寄生蟲在感染此等寄生蟲之動物中之發病率，使此等寄生蟲降至無害程度。更明確言之，本文所採用之「控制」係指式(I)化合物可以殺死各寄生蟲、抑制其生長或抑制其繁殖。 In the field of animal health, the term "control" or "control" means that the compound of formula (I) is effective in reducing the incidence of specific parasites in animals infected with such parasites, rendering such parasites harmless. degree. More specifically, "control" as used herein refers to a compound of formula (I) that kills, inhibits, or inhibits the growth of various parasites.

節肢動物包括例如(但不限於)：蝨目(Anoplurida)，例如：盲蝨屬(Haematopinus spp.)、長顎蝨屬(Linognathus spp.)、蝨蟎屬(Pediculus spp.)、陰蝨屬(Phtirus spp.)與管蝨屬(Solenopotes spp.)；食毛目(Mallophagida)及鈍角亞目(Amblycerina)與細角亞目(Ischnocerina)，例如：羽蝨屬(Bovicola spp.)、食蟲虻屬(Damalina spp.)、貓羽蝨屬(Felicola spp.)、毛虱屬(Lepikentron spp.)、雞蝨屬(Menopon spp.)、獸鳥蝨屬(Trichodectes spp.)、毛鳥蝨屬(Trimenopon spp.)、巨毛蝨屬(Trinoton spp.)、嚼蝨屬(Werneckiella spp.)；雙翅目(Diptera)及長角亞目(Nematocerina)與短角亞目(Brachycerina)，例如：伊蚊屬(Aedes spp.)、按蚊屬(Anopheles spp.)、黃虻屬(Atylotus spp.)、蜂虱屬(Braula spp.)、麗蠅屬(Calliphora spp.)、金蠅屬(Chrysomyia spp.)、(Chrysops spp.)、庫蚊屬(Culex spp.)、蚊屬(Culicoides spp.)、真蚋屬(Eusimulium spp.)、廄蠅屬(Fannia spp.)、胃蠅屬(Gasterophilus spp.)、舌蠅屬(Glossina spp.)、血蠅屬(Haematobia spp.)、麻翅虻屬(Haematopota spp.)、蝨蠅屬(Hippobosca spp.)、皮蠅屬(Hypoderma spp.)、齒股蠅屬(Hydrotaea spp.)、瘤虻屬(Hybomitra spp.)、蝨蠅屬(Lipoptena spp.)、綠蠅屬(Lucilia spp.)、沙蠅屬(Lutzomyia spp.)、羊蝨蠅屬(Melophagus spp.)、莫蠅屬(Morellia spp.)、家蠅屬(Musca spp.)、斑虻屬蚋屬(Odagmia spp.)、狂蠅屬(Oestrus spp.)、Philipomyia屬、白蛉屬(Phlebotomus spp.)、鼻狂蠅屬(Rhinoestrus spp.)、麻蠅屬(Sarcophaga spp.)、蚋蚊屬(Simulium spp.)、螫蠅屬(Stomoxys spp.)、虻屬(Tabanus spp.)、大蚊屬(Tipula spp.)、維蚋屬(Wilhelmia spp.)、肉蠅屬(Wohlfahrtia spp.)；蚤目(Siphonapterida)，例如：角葉蚤屬(Ceratophyllus spp.)、櫛頭蚤屬(Ctenocephalides spp.)、蚤屬(Pulex spp.)、潛蚤屬(Tunga spp.)、鼠蚤屬(Xenopsylla spp.)；異翅目(Heteropterida)，例如：臭蟲屬(Cimex spp.)、金圓蝽屬(Panstrongylus spp.)、紅腹獵蝽屬(Rhodnius spp.)、錐蝽屬(Triatoma spp.)；及蜚蠊目(Blattaria)之擾人及衛生害蟲。 Arthropods include, for example, but are not limited to, Anoplurida, for example: Haematopinus spp., Linognathus spp., Pediculus spp., Hazel ( Phtirus spp.) and Solenopotes spp.; Mallophagida and Amblycerina and Ischnocerina, for example: Bovicola spp., carnivorous mites Genus (Damalina spp.), Felicola spp., Lepikentron spp., Menopon spp., Trichodectes spp., Trimenopon Spp.), Trinoton spp., Werneckiella spp.; Diptera and Nematocerina and Brachycerina, eg Aedes Genus (Aedes spp.), Anopheles spp., Atylotus spp., Braula spp., Calliphora spp., Chrysomyia spp. ), (Chrysops spp.), Culex spp., Culicoides spp., Eusimulium spp., Fannia spp., Gasterophilus spp. ), Gypsophila (Gloss Ina spp.), Haematobia spp., Haematopota spp., Hippotosca spp., Hypoderma spp., Hydrotaea spp. ), Hybomitra spp., Lipoptena spp., Lucilia spp., Lutzomyia spp., Melophagus spp., Mosquito Genus (Morellia spp.), Musca spp., Odagmia spp., Oestrus spp., Philipomyia, Phlebotomus spp., nasal mad Rhinoestrus spp., Sarcophaga spp., Simulium spp., Stomoxys spp., Tabanus spp., Tipula spp. , Wilhelmia spp., Wohlfahrtia spp.; Siphonapterida, for example: Ceratophyllus spp., Ctenocephalides spp., genus Pulex spp.), Tunga spp., Xenopsylla spp.; Heteropterida, for example: Cimex spp., Panstrongylus spp., Rhodonius spp., Conus genus Triatoma spp.); and the eyewitness (Blattaria) disturbing people and sanitary pests.

此外，可述及之節肢動物實例為(但不限於)下列蜱蟲(Acari)： 蜱蟲(Acari)之亞綱(蜱蟎亞綱(Acarina))及後氣亞目(Metastigmata)，例如：軟蜱科(Argasidae)，如：銳緣蜱屬(Argas spp.)、鈍緣蜱屬(Ornithodorus spp.)、殘緣蜱屬(Otobius spp.)；硬蜱科(Ixodidae)，如：花蜱屬(Amblyomma spp.)、革蜱屬(Dermacentor spp.)、血蜱屬(Haemophysalis spp.)、璃眼蜱屬(Hyalomma spp.)、硬蜱屬(Ixodes spp.)、扇頭蜱(Rhipicephalus(牛蜱(Boophilus))屬、扇頭蜱屬(Rhipicephalus spp.)(多重宿主蜱之原始屬種)；中氣亞目(Mesostigmata)，如：刺皮蟎屬(Dermanyssus spp.)、禽剌蟎屬(Ornithonyssus spp.)、肺刺蟎屬(Pneumonyssus spp.)、耳蟎屬(Raillietia spp.)、胸孔蟎屬(Sternostoma spp.)、Tropilaelaps spp.，、瓦蟎屬(Varroa spp.)；光芒蟲亞目(Actinedida)(前氣亞目(Prostigmata))，例如：蜂蟎屬(Acarapis spp.)、姬蟄蟎屬(Cheyletiella spp.)、脂蟎屬(Demodex spp.)、螫蟎屬(Listrophorus spp.)、肉蟎屬(Myobia spp.)、新恙蟎屬(Neotrombicula spp.)、禽螫蟎屬(Ornithocheyletia spp.)、綿羊疥蟎屬(Psorergates spp.)、恙蟎屬(Trombicula spp.)；及粉蟎亞目(Acaridida)(無氣亞目(Astigmata))，例如：粉蟎屬(Acarus spp.)、嗜木蟎屬(Caloglyphus spp.)、皮蟎屬(Chorioptes spp.)、雞蟎屬(Cytodites spp.)、皮頸下蟎屬(Hypodectes spp.)、鳥疥蟎屬(Knemidocoptes spp.)、雞雛蟎屬(Laminosioptes spp.)、耳蟎屬(Notoedres spp.)、耳蟎屬(Otodectes spp.)、癢蟎屬(Psoroptes spp.)、翼蟎屬(Pterolichus spp.)、疥蟎屬(Sarcoptes spp.)、疥癬恙蟲屬(Trixacarus spp.)、食酪蟎屬(Tyrophagus spp.)。 Further, examples of arthropods that may be mentioned are, but are not limited to, the following aphids: Acari (Acarina) and Metastimmata, for example: Argasidae, such as: Argas spp., Ornithodorus spp., Otobius spp.; Ixodidae, such as flower bud Genus (Amblyomma spp.), Dermacentor spp., Haemophysalis spp., Hyalomma spp., Ixodes spp., Rhipicephalus Boophilus genus, Rhipicephalus spp. (original genus of multiple hosts); Mesostigmata, such as Dermanyssus spp., fowl Genus (Ornithonyssus spp.), Pneumonyssus spp., Raillietia spp., Sternostoma spp., Tropilaelaps spp., Varroa spp. Actinedida (Prostigmata), for example: Acarapis spp., Cheyletiella spp., Demodex spp., Amaranthus (Listrophorus spp.) , Myobia spp., Neotrombicula spp., Ornithocheyletia spp., Psorergates spp., Trimculcula spp.; Acaridida (Astigmata), for example: Acarus spp., Caloglyphus spp., Chorioptes spp., Chicken genus (Cytodites spp.), Hypodectes spp., Knemidocoptes spp., Laminosioptes spp., Notoedres spp., Otodectes Spp.), Psoroptes spp., Pterolichus spp., Sarcoptes spp., Trixacarus spp., Tyrophagus spp. .

寄生性原蟲實例包括(但不限於)： 鞭毛門(Mastigophora)(鞭毛動物綱(Flagellata))，如：後滴門(Metamonada)：雙滴蟲目(Diplomonadida)，例如：賈第氏滴蟲屬(Giardia spp.)、旋核蟲屬(Spironucleus spp.) Examples of parasitic protozoa include (but are not limited to): Mastigophora (Flagellata), such as: Metamonada: Diplomonadida, for example: Trichomonas sinensis Genus (Giardia spp.), genus Spironucleus spp.

副基體綱(Parabasala)：毛滴蟲目(Trichomonadida)，例如：組織鞭毛蟲屬(Histomonas spp.)、五毛滴蟲屬(Pentatrichomonas spp.)、四毛滴蟲屬(Tetratrichomonas spp.)、毛滴蟲屬(Trichomonas spp.)、三毛滴蟲屬(Tritrichomonas spp.) Parabasala: Trichomonadida, for example: Histomonas spp., Pentatricomonas spp., Tetratrichomonas spp., hair drops Trichomonas spp., Tritrichomonas spp.

眼蟲門(Euglenozoa)：錐蟲科(Trypanosomatida)，例如：利什曼原蟲屬(Leishmania spp.)、錐蟲屬(Trypanosoma spp.) Euglenozoa: Trypanosomatida, for example: Leishmania spp., Trypanosoma spp.

肉質鞭毛蟲門(Sarcomastigophora)((根足蟲綱(Rhizopoda))，如：內阿米巴科(Entamoebidae)(例如：阿米巴蟲屬(Entamoeba spp.))、阿米巴目(Centramoebidae)(例如：棘阿米巴屬(Acanthamoeba sp.))、真變形目(Euamoebidae)(例如：哈曼原蟲屬(Harmanella sp.))。 Sarcomastigophora (Rhizopoda), such as Entamoebidae (eg, Entamoeba spp.), Centramoebidae (eg, Acanthamoeba sp.), Euamoebidae (eg, Harmanella sp.).

囊泡蟲總門(Alveolata)，如：頂複合器門(Apicomplexa)(孢子蟲綱(Sporozoa))，例如：隱孢子蟲屬(Cryptosporidium spp.)；艾美球蟲目(Eimeriida)，例如：貝斯諾孢子蟲屬(Besnoitia spp.)、囊等孢子球蟲屬(Cystoisospora spp.)、艾美球蟲屬(Eimeria spp.)、哈芒球蟲屬(Hammondia spp.)、等孢球蟲屬(Isospora spp.)、新孢子蟲屬(Neospora spp.)、肉孢子蟲屬(Sarcocystis spp.)、弓形蟲屬(Toxoplasma spp.)；住血胞子蟲目(Adeleida)，例如：肝簇蟲屬(Hepatozoon spp.)、球蟲屬(Klossiella spp.)；血孢子蟲目(Haemosporida)，例如：住白細胞原蟲屬(Leucocytozoon spp.)、鼠瘧原蟲屬(Plasmodium spp.)；梨形蟲目(Piroplasmida)，例如：焦蟲屬(Babesia spp.)、纖毛蟲屬(Ciliophora spp.)、Echinozoon屬、泰勒蟲屬(Theileria spp.)；Vesibuliferida目，例如：腸袋蟲屬(Balantidium spp.)、布克斯頓纖毛蟲屬(Buxtonella spp.) Alveolata, such as: Apicomplexa (Sporozoa), for example: Cryptosporidium spp.; Eimeriida, for example: Besnoitia spp., Cystoisospora spp., Eimeria spp., Hammondia spp., Isospora (Isospora spp.), Neospora spp., Sarcocystis spp., Toxoplasma spp.; Adeleida, eg liver genus (Hepatozoon spp.), Klossiella spp.; Haemosporida, for example: Leucocytozoon spp., Plasmodium spp.; Pearworm Piroplasmida, for example, Babesia spp., Ciliophora spp., Echinozoon, Theileria spp.; Vesibuliferida, for example, Balantidium spp. ), Buxtonella spp.

微孢子亞門(Microspora)，如：微孢子蟲屬(Encephalitozoon spp.)、腸胞蟲屬(Enterocytozoon spp.)、球蟲屬(Globidium spp.)、微孢子蟲屬(Nosema spp.)、與例如：黏體動物門(Myxozoa spp.)。 Microspora, such as: Encephalitozoon spp., Enterocytozoon spp., Globidium spp., Nosema spp., and For example: Myxozoa spp.

成為人類或動物之病原菌之蠕蟲包括例如：棘頭動物(Acanthocephala)、線蟲動物門(Nematodes)、舌形動物門(Pentastoma)與扁形動物門(Platyhelminthes)(例如：單殖吸蟲亞綱(Monogenea)、絛蟲(cestodes)與複殖吸蟲(trematodes))。 Worm that becomes a pathogen of human or animal includes, for example, Acanthocephala, Nematodes, Pentastoma, and Platyhelminthes (eg, Monogonella) Monogenea), cestodes and trematodes.

蠕蟲實例包括(但不限於)：單殖吸蟲亞綱(Monogenea)：例如：指標蟲屬(Dactylogyrus spp.)、三代蟲屬(Gyrodactylus spp.)、小盤吸蟲屬(Microbothrium spp.)、多盤吸蟲屬(Polystoma spp.)、Troglecephalus屬；絛蟲：擬葉目(Pseudophyllidea)，例如：吸葉絛蟲屬(Bothridium spp.)、廣節裂頭絛蟲屬(Diphyllobothrium spp.)、大複殖門絛蟲屬(Diplogonoporus spp.)、Ichthyobothrium屬、舌狀絛蟲屬(Ligula spp.)、 裂頭絛蟲屬(Schistocephalus spp.)、螺旋體蟲屬(Spirometra spp.)；圓葉目(Cyclophyllida)，例如：安迪亞絛蟲屬(Andyra spp.)、裸頭絛蟲屬(Anoplocephala spp.)、無卵黃腺絛蟲(Avitellina spp.)、伯特絛蟲屬(Bertiella spp.)、錫帶絛蟲屬(Cittotaenia spp.)、戴文絛蟲屬(Davainea spp.)、迪克氏絛蟲屬(Diochis spp.)、雙孔絛蟲屬(Diplopylidium spp.)、瓜實絛蟲屬(Dipylidium spp.)、棘球絛蟲屬(Echinococcus spp.)、棘葉絛蟲屬(Echinocotyle spp.)、瘍棘殼絛蟲屬(Echinolepis spp.)、泡尾絛蟲屬(Hydatigera spp.)、包膜絛蟲屬(Hymenolepis spp.)、約優克斯絛蟲屬(Joyeuxiella spp.)、中殖孔屬絛蟲屬(Mesocestoides spp.)、莫尼茨絛蟲屬(Moniezia spp.)、副裸頭絛蟲屬(Paranoplocephala spp.)、雷氏絛蟲屬(Raillietina spp.)、史提拉絛蟲屬(Stilesia spp.)、絛蟲屬(Taenia spp.)、曲子官絛蟲屬(Thysaniezia spp.)、隧體絛蟲屬(Thysanosoma spp.) Examples of worms include, but are not limited to, Monoogenea: for example, Dactylogyrus spp., Gyrodactylus spp., Microbothrium spp. , Polystoma spp., Troglecephalus; Aphid: Pseudophyllidea, for example: Bothridium spp., Diphyllobothrium spp., Da Fu From the genus Diplogonoporus spp., Ichthyobothrium, Ligula spp., Schistocephalus spp., Spirometra spp., Cyclophyllida, for example : Andyra spp., Anoplocephala spp., Avitellina spp., Bertiella spp., Cittotaenia spp. ), Davainea spp., Diochis spp., Diplopylidium spp., Dipylidium spp., Echinococcus spp. ), Echinocotyle spp., Aphis gossypii (Echinolepis) Spp.), Hydatigera spp., Hymenolepis spp., Joyeuxiella spp., Mesocestoides spp., Moni Moniezia spp., Paranoplocephala spp., Raillietina spp., Stilesia spp., Taenia spp., tune Thysaniezia spp., Thysanosoma spp.

複殖吸蟲：複殖綱(Digenea)，例如：澳畢吸蟲屬(Austrobilharzia spp.)、短咽吸蟲屬(Brachylaima spp.)、杯殖吸蟲屬(Calicophoron spp.)、下彎吸蟲屬(Catatropis spp.)、支睪吸蟲屬(Clonorchis spp.)、肛瘤吸蟲屬(Collyriclum spp.)、盤吸蟲屬(Cotylophoron spp.)、環腸吸蟲屬(Cyclocoelum spp.)、雙腔吸蟲屬(Dicrocoelium spp.)複口吸蟲屬(Diplostomum spp.)、棘隙吸蟲屬(Echinochasmus spp.)、棘緣吸蟲屬(Echinoparyphium spp.)、棘口吸蟲屬(Echinostoma spp.)、闊盤吸蟲屬(Eurytrema spp.)、肝吸蟲屬(Fasciola spp.)、擬片形吸蟲屬(Fasciolides spp.)、薑片蟲屬(Fasciolopsis spp.)、菲策吸蟲屬(Fischoederius spp.)、腹袋吸蟲屬(Gastrothylacus spp.)、巨畢吸蟲屬(Gigantobilharzia spp.)、巨盤吸蟲屬(Gigantocotyle spp.)、異形吸蟲屬(Heterophyes spp.)、低頸吸蟲屬(Hypoderaeum spp.)、彩蚴吸蟲屬(Leucochloridium spp.)、後殖吸蟲屬(Metagonimus spp.)、次睾吸蟲屬(Metorchis spp.)、隱孔吸蟲屬(Nanophyetus spp.)、背孔吸蟲屬(Notocotylus spp.)、後睾吸蟲屬(Opisthorchis spp.)、毛樣線蟲屬(Ornithobilharzia spp.)、並殖吸蟲屬(Paragonimus spp.)、雙口吸蟲屬(Paramphistomum spp.)、斜睾吸蟲屬(Plagiorchis spp.)、莖雙穴吸蟲屬(Posthodiplostomum spp.)、前殖吸蟲屬(Prosthogonimus spp.)、血吸蟲屬(Schistosoma spp.)、毛畢屬 (Trichobilharzia spp.)、鮭吸蟲屬(Troglotrema spp.)、盲腔屬(Typhlocoelum Spp.) Recombinant trematode: Digenea, for example: Austrobilharzia spp., Brachylaima spp., Calicophoron spp., lower bend Catatropis spp., Clonorchis spp., Collyriclum spp., Cotylophoron spp., Cyclocoelum spp. Dicrocoelium spp., Diclostomum spp., Echinochasmus spp., Echinoparyphium spp., R. genus Echinostoma spp.), Eurytrema spp., Fasciola spp., Fasciolides spp., Fasciolopsis spp., Fize F. sylvestris (Fischoederius spp.), Gastrothylacus spp., Gigantobilharzia spp., Gigantocotyle spp., Heterophyes spp. ), Hypoderaeum spp., Leucochloridium spp., Metagonimus spp., Metalschis spp., hidden hole (Nanophyetus spp.), Notocotylus spp., Opisthorchis spp., Ornithobilharzia spp., Paragonimus spp. , Paramphistomum spp., Plagiorchis spp., Posthodiplostomum spp., Prosthogonimus spp., Schistosoma Spp.), Trichobilharzia spp., Troglotrema spp., Typhlocoelum Spp.

線蟲：毛形亞目(Trichinellida)，例如：毛細線蟲屬(Capillaria spp.)、旋毛蟲屬(Trichinella spp.)、線蟲屬(Trichomosoides spp.)、毛首線蟲屬(Trichuris spp.) Nematodes: Trichinellida, for example: Capillaria spp., Trichinella spp., Trichomosoides spp., Trichuris spp.

墊刃目(Tylenchida)，例如：細頸線蟲屬(Micronema spp.)、副糞桿線蟲屬(Parastrangyloides spp.)、糞桿線蟲屬(Strongyloides spp.) Tylenchida, for example: Micronema spp., Parastrangyloides spp., Strongyloides spp.

小桿亞目(Rhabditina)，例如：貓圓線蟲屬(Aelurostrongylus spp.)、裂口線蟲屬(Amidostomum spp.)、鉤蟲屬(Ancylostoma spp.)、住血線蟲屬(Angiostrongylus spp.)、Bronchonema屬、仰口線蟲屬(Bunostomum spp.)、腸線蟲屬(Chabertia spp.)、古柏線蟲屬(Cooperia spp.)、Cooperioides spp.、環體線蟲屬(Crenosoma spp.)、節蟲屬(Cyathostomum spp.)、線蟲屬(Cyclococercus spp.)、環齒口鉤蟲屬(Cyclodontostomum spp.)、杯環線蟲屬(Cylicocyclus spp.)、杯冠線蟲屬(Cylicostephanus spp.)、柱咽線蟲屬(Cylindropharynx spp.)、囊尾線蟲屬(Cystocaulus spp.)、網尾線蟲屬(Dictyocaulus spp.)、鹿圓線蟲屬(Elaphostrongylus spp.)、類絲線蟲屬(Filaroides spp.)、球首線蟲屬(Globocephalus spp.)、毛樣線蟲屬(Graphidium spp.)、輻首線蟲屬(Gyalocephalus spp.)、血矛線蟲屬(Haemonchus spp.)、螺旋線蟲屬(Heligmosomoides spp.)、胃圓線蟲屬(Hyostrongylus spp.)、馬歇爾線蟲屬(Marshallagia spp.)、後圓線蟲屬(Metastrongylus spp.)、繆勒線蟲屬(Muellerius spp.)、鉤蟲屬(Necator spp.)、細頸線蟲屬(Nematodirus spp.)、新圓線蟲屬(Neostrongylus spp.)、日圓線蟲屬(Nippostrongylus spp.)、尖頭胃線蟲屬(Obeliscoides spp.)、食道齒線蟲屬(Oesophagodontus spp.)、結線蟲屬(Oesophagostomum spp.)、壺肛線蟲屬(Ollulanus spp.)、圓蟲屬(Ornithostrongylus spp.)、奧斯勒絲蟲屬(Oslerus spp.)、胃絲蟲屬(Ostertagia spp.)、副古柏線蟲屬(Paracooperia spp.)、副環體線蟲屬(Paracrenosoma spp.)、副類絲線蟲屬(Parafilaroides spp.)、副麂圓線蟲屬(Parelaphostrongylus spp.)、肺尾屬(Pneumocaulus spp.)、肺圓線蟲屬(Pneumostrongylus spp.)、盆口線蟲屬(Poteriostomum spp.)、原圓線蟲屬(Protostrongylus spp.)、指尾線蟲 屬(Spicocaulus spp.)、冠尾線蟲屬(Stephanurus spp.)、圓線蟲屬(Strongylus spp.)、比翼線蟲屬(Syngamus spp.)、牛胃絲蟲屬(Teladorsagia spp.)、毛線線蟲屬(Trichonema spp.)、毛圓線蟲屬(Trichostrongylus spp.)、三齒線蟲屬(Triodontophorus spp.)、隱圓屬(Troglostrongylus spp.)、彎口線蟲屬(Uncinaria spp.) Rhabditina, for example, Aelurostrongylus spp., Amidostomum spp., Ancylostoma spp., Angiostrongylus spp., Bronchonema, The genus Bunostomum spp., Chabertia spp., Cooperia spp., Cooperioides spp., Crenosoma spp., Cyathostomum spp. ), Cyclococercus spp., Cyclodontostomum spp., Cylicocyclus spp., Cylicostephanus spp., Cylindropharynx spp. , Cystocaulus spp., Dictyocaulus spp., Elaphostrongylus spp., Filaroides spp., Globocephalus spp. , Graphidium spp., Gyalocephalus spp., Haemonchus spp., Heligmosomoides spp., Hyostrongylus spp. Marshallal genus (Marshallagia spp.), rear round line (Metastrongylus spp.), Muellerius spp., Necator spp., Nematodirus spp., Neostrongylus spp., Nippostrongylus Spp.), Obeliscoides spp., Oesophagodontus spp., Oesophagostomum spp., Ollulanus spp., Ornithostrongylus spp .), Oslerus spp., Ostertagia spp., Paracooperia spp., Paracrenosoma spp., sub-filament Parafilaroides spp., Parelaphostrongylus spp., Pneumocaulus spp., Pneumostrongylus spp., Poteriostomum spp., original circle Protostrongylus spp., Spicocaulus spp., Stephanurus spp., Strongylus spp., Syngamus spp., Bovine filaria Genus (Teladorsagia spp.), genus Trichonema spp., hairy line Trichostrongylus spp., Triodontophorus spp., Troglostrongylus spp., Uncinaria spp.

旋尾目(Spirurida)，例如：棘唇蟲屬(Acanthocheilonema spp.)、海獸胃線蟲屬(Anisakis spp.)、禽蛔屬(Ascaridia spp.)、蛔蟲屬(Ascaris spp.)、螺咽屬(Ascarops spp.)、無刺蟯蟲屬(Aspiculuris spp.)、貝利蛔蟲屬(Baylisascaris spp.)、布魯線蟲屬(Brugia spp.)、Cercopithifilaria屬、寄生線蟲(Crassicauda spp.)、雙瓣線蟲屬(Dipetalonema spp.)、血直絲蟲屬(Dirofilaria spp.)、龍線蟲屬(Dracunculus spp.)、德拉西線蟲屬(Draschia spp.)、蟯蟲屬(Enterobius spp.)、絲蟲屬(Filaria spp.)、棘口線蟲屬(Gnathostoma spp.)、筒線蟲屬(Gongylonema spp.)、馬胃線蟲屬(Habronema spp.)、異刺線蟲屬(Heterakis spp.)、光絲蟲屬(Litomosoides spp.)、羅阿絲蟲屬(Loa spp.)、蟠尾絲蟲屬(Onchocerca spp.)、尖尾線蟲屬(Oxyuris spp.)、副柔絲線蟲屬(Parabronema spp.)、類絲蟲屬(Parafilaria spp.)、副蛔屬(Parascauis spp.)、栓尾線蟲屬(Passalurus spp.)、泡翼線蟲屬(Physaloptera spp.)、普氏線蟲屬(Probstmayria spp.)、假絲蟲屬(Pseudofilaria spp.)、絲狀線蟲屬(Setaria spp.)、Skjrabinema屬、旋尾線蟲屬(Spirocerca spp.)、冠絲蟲屬(Stephanofilaria spp.)、圓蟲屬(Strongyluris spp.)、管狀線蟲屬(Syphacia spp.)、吸吮線蟲屬(Thelazia spp.)、弓蛔屬(Toxascaris spp.)、弓首線蟲屬(Toxocara spp.)、吳策線蟲屬(Wuchereria spp.) Spirurida, for example: Acanthocheilonema spp., Anisakis spp., Ascaridia spp., Ascaris spp., Ascarops Spp.), Aspiculuris spp., Baylisascaris spp., Brugia spp., Cercopithifilaria, Crassicauda spp., C. elegans (Dipetalonema spp.), Dirofilaria spp., Dracunculus spp., Draschia spp., Enterobius spp., Filaria Filaria spp.), Gnathostoma spp., Gongylonema spp., Habronema spp., Heterakis spp., Litomosoides Spp.), Loa spp., Onchocerca spp., Oxyuris spp., Parabronema spp., Filaria Genus (Parafilaria spp.), Parascauis spp., Passalus spp., Physaloptera spp., P. elegans (Probstmayria spp.), Pseudofilaria spp., Setaria spp., Skjrabinema, Spirocerca spp., Stephanofilaria spp., round Strongyluris spp., Syphacia spp., Thelazia spp., Toxascaris spp., Toxocara spp., Wucer nematode Wuchereria spp.)

棘頭動物(Acanthocephala)：少棘目(Oligacanthorhynchida)，例如：巨吻棘頭蟲屬(Macracanthorhynchus spp.)、前睾棘頭蟲屬(Prosthenorchis spp.)；念珠目(Moniliformida)，例如：聯珠狀棘頭蟲屬(Moniliformis spp.)多形目(Polymorphida)，例如：細頸棘頭蟲屬(Filicollis spp.)；棘吻目(Echinorhynchida)，例如：棘頭蟲屬(Acanthocephalus spp.)、魚棘頭蟲屬(Echinorhynchus spp.)、似細吻棘頭蟲屬(Leptorhynchoides spp.) Acanthocephala: Oligacanthorhynchida, for example: Macracanthorhynchus spp., Prosthenorchis spp.; Moniliformida, eg, Lianzhu Polymorphida, such as: Polycollida spp.; Echinorhynchida, for example, Acanthocephalus spp. Echinorhynchus spp., Leptorhynchoides spp.

舌形動物門(Pentastoma)：孔頭蟲目(Porocephalida)，例如：舌形蟲屬 (Linguatula spp.)。 Pentastoma: Porocephalida, for example: Linguatula spp.

在獸醫與動物飼養領域中，式(I)化合物係呈合適之製劑型式，採用相關技藝上已知方法投藥，如：經腸、非經腸式、經皮膚或經鼻途徑投藥。該投藥法可為預防性、補救性預防(metaphylactic)或治療性。 In the field of veterinary and animal feeding, the compound of formula (I) is in a suitable formulation and is administered by methods known in the art, such as enteral, parenteral, transdermal or nasal routes. The administration method can be prophylactic, metaphylactic or therapeutic.

因此，本發明一項具體實施例係使用式(I)化合物作為醫藥。 Thus, a particular embodiment of the invention uses a compound of formula (I) as a medicament.

本發明另一態樣係有關使用式(I)化合物作為抗體內寄生蟲劑。 Another aspect of the invention pertains to the use of a compound of formula (I) as an antibody endoparasite.

本發明另一態樣係有關使用式(I)化合物作為抗蠕蟲劑，尤指作為殺線蟲劑、殺扁平蠕蟲劑、殺棘頭蟲劑或殺舌形動物劑。 Another aspect of the invention relates to the use of a compound of formula (I) as an anthelmintic, especially as a nematicide, a flattening worm, a echinoderma or a morphogen.

本發明另一態樣係有關使用式(I)化合物作為抗原蟲劑。 Another aspect of the invention relates to the use of a compound of formula (I) as an anti-protozoal agent.

本發明另一態樣係有關使用式(I)化合物作為抗體外寄生蟲劑，尤指殺節肢動物劑，極特定言之為殺昆蟲劑或殺蜱蟎劑。 Another aspect of the invention relates to the use of a compound of formula (I) as an antibody ectoparasite, especially an arthropodicide, in particular an insecticide or an acaricide.

本發明另一態樣係有關一種獸醫學調配物，其包含有效量之至少一種式(I)化合物與至少一種下列製劑：醫藥上可接受之賦形劑(例如：固態或液態稀釋劑)、醫藥上可接受之輔劑(例如：界面活性劑)，尤指常用於獸醫學調配物中之醫藥上可接受之賦形劑與/或常用於獸醫學調配物中之醫藥上可接受之輔劑。 Another aspect of the invention relates to a veterinary formulation comprising an effective amount of at least one compound of formula (I) and at least one of the following: a pharmaceutically acceptable excipient (eg, a solid or liquid diluent), Pharmaceutically acceptable adjuvants (eg, surfactants), especially pharmaceutically acceptable excipients commonly used in veterinary formulations and/or pharmaceutically acceptable supplements commonly used in veterinary formulations Agent.

本發明一相關態樣係一種製造本文所說明獸醫學調配物之方法，其包括混合至少一種式(I)化合物與醫藥上可接受之賦形劑與/或輔劑，尤指常用於獸醫學調配物中之醫藥上可接受之賦形劑與/或常用於獸醫學調配物中之輔劑之步驟。 A related aspect of the invention is a method of making a veterinary formulation as described herein, comprising mixing at least one compound of formula (I) with a pharmaceutically acceptable excipient and/or adjuvant, especially for veterinary medicine The step of pharmaceutically acceptable excipients and/or adjuvants commonly used in veterinary formulations.

本發明另一明確態樣係一種選自殺體外寄生蟲與殺體內寄生蟲調配物之群中之獸醫學調配物，尤指選自殺蠕蟲、抗原蟲與殺節肢動物調配物之群中，極特定言之係選自根據上述態樣之殺線蟲、殺扁平蠕蟲、殺棘頭蟲、殺舌形動物、殺昆蟲與殺蜱蟎調配物之群，及其製造方法。 Another clarified aspect of the invention is a veterinary formulation selected from the group consisting of an ectoparasite and an in vivo parasite formulation, particularly selected from the group consisting of helminth, antigenic and arthropod formulations, Specifically, the system is selected from the group consisting of nematicidal, flattened worm, echinoderma, morphogen, insecticidal and acaricidal formulations according to the above aspects, and a method for producing the same.

另一態樣係有關一種使用有效量之式(I)化合物，為有需要之動物(尤指非人類動物)治療寄生蟲感染，尤指因選自本文所述體外寄生蟲與體內寄生蟲之群組中之寄生蟲所引起之感染之方法。 Another aspect relates to the use of an effective amount of a compound of formula (I) for the treatment of a parasitic infection in an animal in need thereof, especially a non-human animal, especially as selected from the ectoparasites and endoparasites described herein. A method of infection caused by parasites in a group.

另一態樣係有關一種使用本文所定義之獸醫學調配物，為有需要之動物(尤指非人類動物)治療寄生蟲感染，尤指因選自本文所述體外寄生蟲 與體內寄生蟲之群組中之寄生蟲所引起之感染之方法。 Another aspect relates to the use of a veterinary formulation as defined herein for the treatment of a parasitic infection in an animal in need thereof, particularly a non-human animal, especially as selected from the ectoparasites and endoparasites described herein. A method of infection caused by parasites in a group.

另一態樣係有關一種以式(I)化合物於治療動物(尤指非人類動物)之寄生蟲感染上之用途，尤指因選自本文所述體外寄生蟲與體內寄生蟲之群組中之寄生蟲所引起之感染。 Another aspect relates to the use of a compound of formula (I) for the treatment of a parasitic infection in an animal, in particular a non-human animal, in particular in a group selected from the group consisting of ectoparasites and endoparasites described herein. An infection caused by parasites.

本發明動物健康或獸醫學內容中，術語「治療(treatment)」包括預防性、補救性預防(metaphylactic)與治療性(therapeutic)處理。 In the animal health or veterinary content of the present invention, the term "treatment" includes prophylactic, metaphylactic and therapeutic treatments.

依此方式，在特定具體實施例中，為獸醫學領域提供至少一種式(I)化合物與其他活性成份(尤指殺體內與體外寄生蟲藥)之混合物在動物健康領域中，「混合物」不僅指兩種(或更多種)不同活性成份調配成同一調配物中，因此係共同使用，而且係有關一種包含各活性成份之分開調配物之產品。因此，當使用兩種以上活性成份時，所有活性成份均調配成同一調配物或所有活性成份可調配成分開調配物；同樣可理解之混合型式為其中有些活性成份係共同調配，及有些活性成份係分開調配。分開調配物可以分開或連續施用該相關活性成份。 In this manner, in a particular embodiment, a mixture of at least one compound of formula (I) with other active ingredients (especially bactericidal and ectoparasites) is provided in the field of veterinary medicine in the field of animal health, the "mixture" not only It is meant that two (or more) different active ingredients are formulated into the same formulation and are therefore used together, and are related to a product comprising separate formulations of the active ingredients. Therefore, when two or more active ingredients are used, all active ingredients are formulated into the same formulation or all active ingredient-adjustable ingredients. It is also understood that the mixed form is that some of the active ingredients are co-formulated, and some active ingredients Separately deployed. The separate actives can be administered separately or sequentially.

本文中以其「俗名」稱呼之活性成份為已知者且說明於例如：「The Pesticide Manual」(如上述)，或可搜尋網際網路(例如：http：//www.alanwood.net/pesticides)。 The active ingredients referred to herein as "common names" are known and described, for example, in "The Pesticide Manual" (as described above), or may be searched the Internet (eg http://www.alanwood.net/pesticides) ).

選自殺體外寄生蟲劑群組中作為混合組份之活性成份實例包括(但不限於)上文詳細列出之殺昆蟲劑與殺蜱蟎劑。其他可使用之活性成份係依據上文中根據最新IRAC作用模式分類圖(IRAC Mode of Action Classification Scheme)列於下文中：(1)乙醯基膽鹼酯酶(AChE)抑制劑；(2)GABA-閘控之氯離子通道阻斷劑；(3)鈉通道調控劑；(4)菸鹼激導性乙醯基膽鹼受體(nAChR)競爭性調控劑；(5)菸鹼激導性乙醯基膽鹼受體(nAChR)異位性調控劑；(6)麩胺酸閘控氯離子通道(GluCl)異位性調控劑；(7)幼保激素擬似物；(8)其他非特異性(多重位點)抑制劑；(9)弦音感覺器官調控劑；(10)蟎生長抑制劑；(12)粒線體ATP合成酶抑制劑，如：ATP瓦解劑；(13)破壞質子梯度之氧化性磷酸化反應去偶合劑；(14)菸鹼激導性乙醯基膽鹼受體通道阻斷劑；(15)幾丁質生合成抑制劑，第0型；(16)幾丁質生合成抑制劑，第I型；(17)蛻變瓦解劑(尤指雙翅目(Diptera))；(18)脫皮激素受體促效劑；(19)章魚胺受體促效劑；(21) 粒線體複合物I電子轉運抑制劑；(25)粒線體複合物II電子轉運抑制劑；(20)粒線體複合物III電子轉運抑制劑；(22)電壓閘控之鈉通道阻斷劑；(23)乙醯基CoA羧酸酶之抑制劑；(28)蘭尼鹼(ryanodine)受體調控劑；作用機轉未知或非專一性之活性成份，例如：吡氟草胺(fentrifanil)、抗蟎唑(fenoxacrim)、環普靈(cycloprene)、殺蟎酯(chlorobenzilate)、殺蟲脒(chlordimeform)、氟苯滅(flubenzimin)、地昔尼爾(dicyclanil)、艾滅得(amidoflumet)、滅蟎猛(quinomethionat)、苯蟎噻(triarathene)、氯噻苯(clothiazoben)、殺蟎好(tetrasul)、油酸鉀、石油、噁蟲酮(metoxadiazone)、葛昔普(gossyplur)、氟蟎(flutenzine)、溴蟎酯(brompropylate)、克利得(cryolite)；其他類別化合物，例如：畜蟲威(butacarb)、地麥威(dimetilan)、除線威(cloethocarb)、磷光威(phosphocarb)、亞特松(pirimiphos)(-乙基)、巴拉松(parathion)(-乙基)、蟲蟎畏(methacrifos)、鄰水楊酸異丙基酯、三氯松(trichlorfon)、硫丙磷(sulprofos)、丙蟲磷(propaphos)、硫線磷(sebufos)、吡硫磷(pyridathion)、發硫磷(prothoate)、除線磷(dichlofenthion)、滅賜松(demeton)-S-甲基碸、依殺松(isazofos)、苯腈磷(eyanofenphos)、氯亞胺硫磷(dialifos)、三硫磷(carbophenothion)、特硫磷(autathiofos)、愛吩磷(aromfenvinfos)(-甲基)、穀速松(azinphos)(-乙基)、陶斯松(chlorpyrifos)(-乙基)、丁苯硫磷(fosmethilan)、丙胺磷(iodofenphos)、蔬果磷(dioxabenzofos)、福木松(formothion)、地蟲磷(fonofos)、吡氟硫磷(flupyrazofos)、繁福松(fensulfothion)、乙嘧硫磷(etrimfos)；有機氯化合物，例如：毒殺芬(camphechlor)、林丹(lindane)、飛布達(heptachlor)；或苯基吡唑類，例如：乙醯蟲腈(acetoprole)、吡蟲腈(pyrafluprole)、吡啶氟蟲腈(pyriprole)、氟吡唑蟲(vaniliprole)、維吉黴素(sisapronil)；或異唑啉類，例如：賽蘭(sarolaner)、艾伏樂(afoxolaner)、樂地蘭(lotilaner)、氟樂(fluralaner)；擬除蟲菊酯類，例如：(順式-、反式-)美特寧(metofluthrin)、丙氟菊酯(profluthrin)、三氟醚菊酯(flufenprox)、溴氟菊酯(flubrocythrinate)、苄蟎醚(fubfenprox)、五氟菊酯(fenfluthrin)、普賽吩布(protrifenbut)、二氯 苯醚菊酯(pyresmethrin)、RU15525、環戊烯丙菊酯(terallethrin)、順式-利滅靈(cis-resmethrin)、氯氟醚菊酯(heptafluthrin)、生物乙醚菊酯(bioethanomethrin)、生物氯菊酯(biopermethrin)、芬普寧(fenpyrithrin)、順式-賽滅寧(cis-cypermethrin)、順式-百滅寧(cis-permethrin)、功夫菊酯(clocythrin)、賽洛寧(cyhalothrin)(λ-)、氯波寧(chlovaporthrin)、或鹵化烴化合物(HCH)，類新菸鹼，例如：硝蟲噻(nithiazine)二氯滅(dicloromezotiaz)、三氟普靈(triflumezopyrim)大環內酯類，例如：尼美克定(nemadectin)、抑伏克定(ivermectin)、拉替菌素(latidectin)、莫西克定(moxidectin)、希樂克定(selamectin)、普滅克定(eprinomectin)、得滅克定(doramectin)、抑滅克定(emamectin)苯甲酸鹽；美保黴素肟(milbemycin oxime)硫烯酸酯(triprene)、保幼醚(epofenonane)、二苯丙醚(diofenolan)；生物物質、激素、或費洛蒙類，例如：天然產物，例如：蘇力菌素(thuringiensin)、十二碳二烯醇(codlemone)或印楝組份二硝基酚，例如：敵蟎普(dinocap)、敵蟎通(dinobuton)、樂殺蟎(binapacryl)；苯甲醯基脲類，例如：氟佐隆(fluazuron)、氟幼脲(penfluron)，脒衍生物，例如：氯甲脒(chlormebuform)、蟎蜱胺(cymiazole)、得米地曲(demiditraz)蜂箱蜂蟹蟎殺蜱蟎劑，例如：有機酸類，例如：甲酸、草酸。 Examples of active ingredients in the suicide ectoparasite group as a mixed component include, but are not limited to, the insecticides and acaricides detailed above. Other active ingredients that can be used are listed below according to the latest IRAC Mode of Action Classification Scheme: (1) acetylcholinesterase (AChE) inhibitor; (2) GABA - gated chloride channel blocker; (3) sodium channel modulator; (4) nicotine-induced acetylcholine receptor (nAChR) competitive regulator; (5) nicotine-induced Acetylcholine receptor (nAChR) atopic modulator; (6) glutamate gated chloride channel (GluCl) atopic modulator; (7) juvenile hormone mimics; (8) other non Specific (multiple site) inhibitors; (9) stringy sensory organ modulators; (10) sputum growth inhibitors; (12) mitochondrial ATP synthase inhibitors, such as: ATP disintegrators; (13) destruction of protons Gradient oxidative phosphorylation decoupling agent; (14) nicotine-induced acetylcholine receptor channel blocker; (15) chitinogenic synthesis inhibitor, type 0; (16) chitin synthesis Inhibitor, type I; (17) phlegm-removing agent (especially Diptera); (18) ecdysone receptor agonist; (19) octopamine receptor agonist; (21) Linear complex I electron transport Inhibitor; (25) mitochondrial complex II electron transport inhibitor; (20) mitochondrial complex III electron transport inhibitor; (22) voltage-gated sodium channel blocker; (23) acetyl group An inhibitor of CoA carboxylase; (28) a ryanodine receptor modulator; an active ingredient that acts on an unknown or non-specificity, for example: fentrifanil, fenoxacrim , cycloprene, chlorobenzilate, chlordimeform, flubenzimin, dicyclanil, amidoflumet, quinomethionat , triarathene, clothiazoben, tetrasul, potassium oleate, petroleum, metoxadiazone, gossyplur, fluoroquinone (flutenzine), brompropylate, cryolite; other classes of compounds, such as: butacarb, dimetilan, cloethocarb, phosphocarb, Pirimiphos (-ethyl), parathion (-ethyl), methacrifos, isopropyl salicylate, trichlorfon, thiopropyl phosphate (sulprofos), propaphos, sebufos, pyridathion, prothoate, dichlofenthion, demeton-S-methyl碸, isazofos, eyanofenphos, dialifos, carbophenothion, autathiofos, aromfenvinfos (-methyl) , azinphos (-ethyl), chlorpyrifos (-ethyl), fosmethilan, iodofenphos, dioxabenzofos, formothion, Fonofos, flupyrazofos, fensulfothion, etrimfos; organochlorine compounds, for example, camphechlor , lindane, heptachlor; or phenylpyrazoles, for example: acetoprole, pyrafluprole, pyriprazole, pyropyrazole Vaniliprole), sisapronil; or different Oxazolines, for example: sarolaner, afoxolaner, lotilaner, fluraraner; pyrethroids, for example: (cis-, trans-) Metofluthrin, profluthrin, flufenprox, flubrocythrinate, fubfenprox, fenfluthrin, prasin Protrifenbut, pyresmethrin, RU15525, terallethrin, cis-resmethrin, heptafluthrin, bioether Bioethanomethrin, biopermethrin, fenpyrithrin, cis-cypermethrin, cis-permethrin, clocythrin , cyhalothrin (λ-), chlovaporthrin, or halogenated hydrocarbon compound (HCH), neonicotinoids, such as: (nithiazine) dichloromethane (dicloromezotiaz), triflumezopyrim macrolides, for example: nemadectin, ivermectin, latidectin, moxidectin , selbeectin, eprinomectin, doramectin, emamectin benzoate; milbemycin oxime thiolate ( Triprene), epofenonane, diofenolan; biological substances, hormones, or pheromones, such as natural products such as: thuringiensin, dodecadienyl alcohol (codlemone) or neem composition of dinitrophenol, for example: dinocap, dinobuton, binapacryl; benzamidine, such as fluzuron ), penfluron, hydrazine derivatives, such as: chlormebuform, cymiazole, demiditraz, beehives, crabs, acaricides, such as: organic acids, For example: formic acid, oxalic acid.

選自殺體內寄生蟲劑群組作為混合組份之活性成份實例包括(但不限於)：殺蠕蟲活性成份與抗原蟲活性成份。 Examples of active ingredients of the suicide internal parasite group as a mixed component include, but are not limited to, an anthelmintic active ingredient and an antiprotozoal active ingredient.

殺蠕蟲活性成份包括(但不限於)：下列殺線蟲、殺白蟻與/或殺絛蟲活性成份：大環內酯類，例如：普滅克定(eprinomectin)、艾滅克定(abamectin)、尼美克定(nemadectin)、莫西克定(moxidcctin)、得滅克定(doramectin)、希樂克定(selamectin)、利滅克定(lepimectin)、拉替菌素(latidectin)、美保克定(milbemectin)、抑伏克定(ivermectin)、抑滅克定(emamectin)、美保黴素(milbemycin)； 苯并咪唑類與苯硫胍類(probenzimidazoles)，例如：歐苯達唑(oxibendazole)、美苯達唑(mebendazole)、三氯苯咪唑(triclabendazole)、多保淨(thiophanate)、帕苯達唑(parbendazole)、歐菲達唑(oxfendazole)、奈托比胺(netobimin)、菲苯達唑(fenbendazole)、非班太(febantel)、腐絕(thiabendazole)、環苯達唑(cyclobendazole)、卡苯達唑(cambendazole)、阿苯達唑(albendazole)-亞碸、阿苯達唑(albendazole)、伏苯達唑(flubendazole)；縮酸肽類(depsipeptides)，較佳為環狀縮酸肽類，尤指例如：24-員環狀縮酸肽類，例如：恩得肽(emodepside)、PF1022A；四氫嘧啶類，例如：摩朗得(morantel)、哌喃噻(pyrantel)、間酚嘧啶(oxantel)；咪唑并噻唑類，例如：丁咪唑(butamisole)、左旋咪唑(levamisole)、四咪唑(tetramisole)；胺基苯基脒類，例如：阿米登太(amidantel)、脫醯基阿米登太(deacylated amidantel)(dAMD)、三苯雙脒(tribendimidine)；胺基乙腈類，例如：莫米松(monepantel)；派拉荷醯胺類(paraherquamides)，例如：派拉荷醯胺(paraherquamide)、得曲恩特(derquantel)；水楊醯基替苯胺類，例如：三溴柳苯胺(tribromsalan)、溴氟硝柳胺(bromoxanide)、溴硫醯胺(brotianide)、氯碘柳苯胺(clioxanide)、氯氰碘柳胺(closantel)、耐克螺(niclosamide)、氯羥柳胺(oxyclozanide)、碘醚柳胺(rafoxanide)；經取代之苯酚類，例如：硝羥碘芐腈(nitroxynil)、硫雙二氯酚(bithionol)、二碘硝酚(disophenol)、六氯酚(hexachlorophene)、聯硝氯酚(niclofolan)、甲聯硝氯酚(meniclopholan)；有機磷酸酯類，例如：三氯松(trichlorfon)、萘樂弗斯(naphthalofos)、二氯松(dichlorvos)/DDVP、育畜磷(crufomate)、庫伏斯(coumaphos)、納洛酮(haloxone)；哌酮/喹啉類，例如：吡喹酮(praziquantel)，依西太爾(epsiprantel)； 哌類，例如：哌、羥基(hydroxyzine)；四環素類，例如：四環素、氯四環素、去氧羥四環素(doxycycline)、氧四環素(oxytetracycline)、羅利環素(rolitetracycline)；各種不同其他類別，例如：丁萘脒(bunamidine)、硝唑咪(niridazole)、雷瑣侖太(resorantel)、臍菇亭(omphalotin)、奧替普拉(oltipraz)、硝硫氰酯(nitroscanate)、硝羥碘芐腈(nitroxynil)、奥沙尼喹(oxamniquin)、滅樂散(mirasan)、盧甘宋(miracil)、魯坎松(lucanthon)、海恩酮(hycanthon)、海妥林(hetolin)、吐根鹼(emetin)、二乙基卡馬西平(diethylcarbamazine)、二氯芬(dichlorophen)、地芬尼泰(diamfenetide)、可那氮平(clonazepam)、芐芬寧(bephenium)、硝硫氰胺(amoscanate)、氯舒隆(clorsulon)。 The helminth active ingredients include, but are not limited to, the following nematicidal, termite-killing and/or acaricidal active ingredients: macrolides such as eprinomectin, abamectin, Nemadectin, moxidcctin, doramectin, selamectin, lepimectin, latidectin, melbourne Milbemectin, ivermectin, emamectin, milbemycin; benzimidazoles and probenzimidazoles, eg oxibendazole , mebendazole, triclabendazole, thiophanate, parbendazole, oxfendazole, netobimin, phenanthrene Fenbendazole, febantel, thiabendazole, cyclobendazole, cambendazole, albendazole-arylene, albendazole (albendazole), flubendazole; depsipeptides, preferably cyclic acid-reducing peptides In particular, for example, 24-membered cyclic acid-reducing peptides, for example: emodepside, PF 1022A; tetrahydropyrimidines, for example: morantel, pyrantel, meta-phenol pyrimidine (oxantel); imidazothiazoles, for example: butamisole, levamisole, tetramisole; aminophenyl hydrazines, for example: amidantel, azurapyl Deacylated amidantel (dAMD), tribendimidine; aminoacetonitriles such as: monepantel; paraherquamides, eg, palladium amide ( Paraherquamide), derquantel; salicyl anilide, for example: tribromsalan, bromoxanide, brotianide, clooxanide ), closantel, niclosamide, oxyclozanide, rafoxanide; substituted phenols, for example, nitroxynil, Bithionol, disophenol, hexachlorophene Niclofolan, meniclopholan; organophosphates such as trichlorfon, naphthalofos, dichlorvos/DDVP, breeding animals Crufomate, coumaphos, haloxone; piperazine Keto/quinolines, for example: praziquantel, epsiprantel; Class, for example: pipe Hydroxyl (hydroxyzine); tetracyclines, for example: tetracycline, chlorotetracycline, doxycycline, oxytetracycline, rolitetracycline; various other classes, such as: bunamidine, nitrozolidine Niridazole, resorantel, omphalotin, oltipraz, nitroscanate, nitroxynil, oxacinquine Oxamniquin), mirasan, miracil, lucanhon, hycanthon, hetolin, emetin, diethyl kama Diethylcarbamazine, dichlorophen, diamfenetide, clonazepam, bephenium, amoxinate, clorsulon.

抗原蟲活性成份包括(但不限於)下列活性成份：三類，例如：地卡珠利(diclazuril)、泊那珠利(ponazuril)、來曲珠利(letrazuril)、托曲珠利(toltrazuril)；聚醚離子載體(ionophores)類，例如：莫能菌素(monensin)、鹽黴素(salinomycin)、馬杜黴素(maduramicin)、甲基鹽黴素(narasin)；大環內酯類，例如：美保黴素(milbemycin)、紅黴素(erythromycin)；喹諾酮類，例如：恩諾沙星(enrofloxacin)、普朵沙星(pradofloxacin)；奎寧類，例如：氯奎寧(chloroquin)；嘧啶類，例如：嘧啶甲胺(pyrimethamine)；磺胺類，例如：磺胺喹啉(sulfaquinoxaline)、甲氧苄啶(trimethoprim)、磺胺氯吡(sulfaclozin)；硫胺素類，例如：胺丙嘧吡啶(amprolium)；林可醯胺類(lincosamide)，例如：克林黴素(clindamycin)；碳醯替苯胺類，例如：雙咪苯脲(imidocarb)；硝基呋喃類，例如：硝呋莫司(nifurtimox)；喹唑啉酮生物鹼類，例如：鹵夫酮(halofuginone)；各種不同其他類別，例如：奥沙尼喹(oxamniquin)、巴龍黴素(paromomycin)；來自微生物之疫苗或抗原類，例如：犬焦蟲(Babesia canis rossi)、 盲腸型球蟲(Eimeria tenella)、早熟艾美球蟲(Eimeria praecox)、毒害艾美球蟲(Eimeria necatrix)、和緩艾美球蟲(Eimeria mitis)、巨型艾美球蟲(Eimeria maxima)、布氏艾美球蟲(Eimeria brunetti)、堆型艾美球蟲(Eimeria acervulina)、焦蟲(Babesia canis vogeli)、嬰兒利什曼蟲(Leishmania infantum)、焦蟲(Babesia canis canis)、牛肺蟲(Dictyocaulus viviparus)。 Antiprotozoal active ingredients include, but are not limited to, the following active ingredients: Classes, for example: diclazuril, ponazuril, letrazuril, toltrazuril; polyether ionophores, eg, monensin Monensin, salinomycin, maduramicin, narasin; macrolides, for example, milbemycin, erythromycin Quinolones, for example: enrofloxacin, pradofloxacin; quinines such as chloroquin; pyrimidines such as pyrimethamine; sulfonamides, For example: sulfaquine Sulfaquinoxaline, trimethoprim, sulfachloropyridinium (sulfaclozin); thiamines, for example: amprolium; lincosamide, for example: clindamycin; carbamazepines, for example: bis-phenylbenzaldehyde (imidocarb); nitrofurans, for example: nifurtimox; quinazolinone alkaloids, for example: halofuginone; various other classes, for example: oxamniquin , paromomycin (paromomycin); vaccines or antigens from microorganisms, such as: Babesia canis rossi, Eimeria tenella, Eimeria praecox, poison Amy Coccidia (Eimeria necatrix), Eimeria mitis, Eimeria maxima, Eimeria brunetti, Eimeria acervulina, coke Babesia canis vogeli, Leishmania infantum, Babesia canis canis, Dictyocaulus viviparus.

上述所有混合組份若可能時，亦可依據其官能基，與合適鹼類或酸類形成鹽類。 All of the above mixed components may form salts with suitable bases or acids depending on their functional groups, if possible.

病媒控制Vector control

式(I)化合物亦可用於控制病媒。本發明內容中，病媒係會從帶原者(植物、動物、人類，等等)傳播病原菌(例如：病毒、蠕蟲、單細胞生物與細菌)給宿主之節肢動物，尤指昆蟲或蜘蛛類。該病原菌可經由機械式傳播至宿主(例如：經由非叮咬性蠅傳播之沙眼)或經由注入傳播至宿主(例如：由蚊子傳播之瘧疾寄生蟲)。 The compounds of formula (I) can also be used to control vectors. In the context of the present invention, a disease vector system transmits pathogenic bacteria (eg, viruses, worms, single-celled organisms, and bacteria) from the original (plants, animals, humans, etc.) to the host arthropods, especially insects or spiders. class. The pathogen can be transmitted mechanically to the host (eg, trachoma via non-bite flies) or via injection to a host (eg, malaria parasite transmitted by mosquitoes).

病媒及其所傳播之疾病或病原菌之實例為：1)蚊子- 按蚊(Anopheles)：虐疾、絲蟲病；- 庫蚊(Culex)：日本腦炎、絲蟲病、其他病毒疾病、其他蠕蟲之傳播；- 伊蚊(Aedes)：黃熱病、登革熱、其他病毒疾病、絲蟲病；- 蚋科(Simuliidae)：傳播蠕蟲，尤指盤尾線蟲(Onchocerca volvulus)；- 蛾蚋科(Psychodidae)：傳播利什曼原蟲症；2)蝨：皮膚傳染病、流行性斑疹傷寒；3)跳蚤：疫病、鼠型斑疹傷寒、絛蟲；4)蠅：昏睡病(錐蟲病)；霍亂、其他細菌性疾病；5)蟎：家畜疥癣病、流行性斑疹傷寒、立克次痘疹(rickettsialpox)、兔熱病(tularamia)、聖路易腦炎(Saint-Louis encephalitis)、蜱傳播性腦炎(TBE)、克里米亞-剛果惡性血液疾病(Crimean-Congo haematologic fever)、疏螺旋體病(borelliosis)； 6)蜱：疏螺旋體病(borellioses)，如：伯氏疏螺旋體(Borrelia bungdorferi sensu lato)、杜通氏螺旋體(Borrelia duttoni)、蜱傳播性腦炎、Q熱(貝氏考克斯菌(Coxiella burnetii))、焦蟲症(犬焦蟲症(Babesia canis canis))、艾利希氏體症。 Examples of vectors and diseases or pathogens that they transmit are: 1) mosquitoes - Anopheles: malaria, filariasis; - Culex: Japanese encephalitis, filariasis, other viral diseases, Propagation of other worms; - Aedes: yellow fever, dengue fever, other viral diseases, filariasis; - Simuliidae: transmission of worms, especially Onchocerca volvulus; - moth Psychodidae: spread Leishmaniasis; 2) 虱: skin infections, epidemic typhus; 3) fleas: blight, rat typhus, aphids; 4) flies: sleeping sickness (trypan Disease); cholera, other bacterial diseases; 5) 螨: livestock rickets, epidemic typhus, rickettsialpox, tularamia, Saint-Louis encephalitis , 蜱 蜱 脑 encephalitis (TBE), Crimean-Congo haematologic fever, borelliosis; 6) 蜱: Borrelias, such as: Borealis (Borrelia bungdorferi sensu lato), Borrelia duttoni, rumor Encephalitis, Q fever (Bayesian Cox bacteria (Coxiella burnetii)), disease Babesia (Babesia disease in dogs (Babesia canis canis)), Ehrlich's body disease.

本發明內容中之病媒實例為昆蟲，例如：會傳播植物病毒給植物之蚜蟲、蠅、葉蟬或薊馬。其他會傳播植物病毒之病媒為蜘蛛蟎、蝨、甲蟲與線蟲。 Examples of vectors in the context of the present invention are insects, such as aphids, flies, spider mites or thrips that transmit plant viruses to plants. Other vectors that transmit plant viruses are spider mites, mites, beetles and nematodes.

本發明內容中之其他病媒實例為昆蟲與蜘蛛類，如：蚊子，尤指會傳播病原菌給動物與/或人類之伊蚊(Aedes)、按蚊(Anopheles)，例如：甘比亞按蚊(A.gambiae)、阿拉伯按蚊(A.arabiensis)、致死按蚊(A.funestus)、大劣按蚊(A.dirus)(瘧疾)與庫蚊(Culex)、蛾蚋科(Psychodidae)，如：白蛉(Phlebotomus)、羅蛉(Lutzomyia)、蝨、跳蚤、蠅、蟎、與蜱。若式(I)化合物可突破抗性時，亦可能用於控制病媒。 Examples of other vectors in the context of the present invention are insects and arachnids, such as: mosquitoes, especially Aedes, Anopheles, Anopheles, etc., which transmit pathogens to animals and/or humans, for example: Anopheles gambiae (A.gambiae), A. arabiensis, A. funestus, A. dirus (malaria) and Culex, Psychodidae, Such as: Phlebotomus, Lutzomyia, cockroach, flea, fly, cockroach, and cockroach. If the compound of formula (I) can break through resistance, it may also be used to control the vector.

式(I)化合物適用於預防由病媒傳播之疾病與/或病原菌。因此本發明另一態樣係以式(I)化合物於控制病媒之用途，例如：用於農業、園藝、森林、花園與休閒活動設施，及亦用於保護材料與庫存產品。 The compounds of formula (I) are useful for the prevention of diseases and/or pathogenic bacteria transmitted by vectors. Thus, another aspect of the invention is the use of a compound of formula (I) for controlling a vector, for example, for use in agricultural, horticultural, forest, garden and recreational activities, and also for protecting materials and stock products.

保護工業材料Protection of industrial materials

式(I)化合物適用於保護工業材料，對抗昆蟲之侵害或破壞，例如：鞘翅目(Coleoptera)、膜翅目(Hymenoptera)、等翅目(Isoptera)、鱗翅目(Lepidoptera)、囓蟲目(Psocoptera)與總尾目(Zygentoma)。咸了解，本文所指之工業材料為無生命材料，如：較佳為塑膠、膠黏劑、膠水、紙張與紙板、皮革、木材、加工木製品與塗料組成物。本發明用途特別適合保護木材。 The compounds of formula (I) are suitable for the protection of industrial materials against insect damage or destruction, for example: Coleoptera, Hymenoptera, Isoptera, Lepidoptera, Diptera (Lepidoptera) Psocoptera) and total tail (Zygentoma). It is understood that the industrial materials referred to herein are inanimate materials, such as: plastics, adhesives, glues, paper and cardboard, leather, wood, processed wood products and coating compositions. The use of the invention is particularly suitable for protecting wood.

另一項具體實施例中，式(I)化合物係與至少一種其他殺昆蟲劑與/或至少一種殺真菌劑共同使用。 In another embodiment, the compound of formula (I) is used in combination with at least one other insecticide and/or at least one fungicide.

另一項具體實施例中，式(I)化合物係呈即用型殺害蟲劑，亦即其不需要進一步修飾即可施用在所需材料上。適用之其他殺昆蟲劑或殺真菌劑特別包括如上述說明者。 In another embodiment, the compound of formula (I) is a ready-to-use insecticide, i.e., it can be applied to the desired material without further modification. Other insecticides or fungicides suitable for use include, inter alia, those described above.

亦已驚人地發現，式(I)化合物可用於保護與鹽水或鹹水接觸之物品，特定言之船體、隔板、編網、建築物、繫船設備及訊號系統，防 止污塞。同樣地，式(I)化合物可單獨使用或與其他活性成份組合，作為抗污塞劑使用。 It has also surprisingly been found that the compounds of formula (I) are useful for protecting articles in contact with salt water or salt water, in particular hulls, partitions, nets, buildings, moorings and signalling systems, to prevent contamination. Likewise, the compounds of formula (I) can be used alone or in combination with other active ingredients as anti-soul plugs.

於衛生領域中控制動物害蟲Control animal pests in the health sector

式(I)化合物適合在衛生領域中控制動物害蟲。更特定言之，本發明可應用在居家保護領域、衛生保護領域及保護庫存產品中，尤其控制出現在例如：住家、廠房、辦公室、車廂、動物畜養設備等封閉空間之昆蟲、蜘蛛、蜱與蟎類。式(I)化合物可單獨使用或與其他活性成份與/或輔劑組合用於控制動物害蟲。其等較佳係家庭用殺昆蟲劑產品。式(I)化合物可有效對抗敏感性及抗性品種，並對抗所有發展階段。此等害蟲包括例如：來自蜘蛛綱(Arachnida)，蠍目(Scorpiones)、蜘蛛目(Araneae)與盲蛛目(Opiliones)；唇足綱(Chilopoda)與重足綱(Diplopoda)；昆蟲綱，蜚蠊目(Blattodea)、鞘翅目(Coleoptera)、革翅目(Dermaptera)、雙翅目(Diptera)、異翅目(Heteroptera)、膜翅目(Hymenoptera)、等翅目(Isoptera)、鱗翅目(Lepidoptera)、毛蝨目(Phthiraptera)、囓蟲目(Psocoptera)、跳躍亞目(Saltatoria)或直翅目(Orthoptera)、蚤目(Siphonaptera)與總尾目(Zygentoma)，及軟甲綱(Malacostraca)等足目(Isopoda)之害蟲。 The compounds of formula (I) are suitable for controlling animal pests in the hygiene sector. More specifically, the present invention can be applied to the field of home protection, health protection, and protection of inventory products, especially insects, spiders, cockroaches and insects that appear in closed spaces such as homes, factories, offices, cars, animal husbandry equipment, and the like.螨 class. The compounds of formula (I) may be used alone or in combination with other active ingredients and/or adjuvants to control animal pests. These are preferably household insecticide products. The compounds of formula (I) are effective against sensitive and resistant varieties and are resistant to all stages of development. Such pests include, for example, from Arachnida, Scorpiones, Araneae and Opiliones; Chilopoda and Diplopoda; Insecta, 蜚Blattodea, Coleoptera, Dermaptera, Diptera, Heteroptera, Hymenoptera, Isoptera, Lepidoptera Lepidoptera), Phthiraptera, Psocoptera, Saltatoria or Orthoptera, Siphonaptera and Zygentoma, and Malacostraca A pest of the Isopoda.

其可呈例如：氣霧劑、無壓力噴灑產品，例如：泵壓及霧化噴灑器、自動噴霧系統、霧化器、發泡物、凝膠、使用由纖維素或塑膠製成之蒸發片之蒸發器產品、液體蒸發器、凝膠及膜式蒸發器、螺漿驅動式蒸發器、無能源或被動式蒸發系統、防蟲紙、防蟲袋及防蟲膠，呈粒狀或塵粉，用於撒播式誘餌或用於誘餌台等形式使用。 It may be, for example, an aerosol, a pressureless spray product such as: a pump and atomizer sprayer, an automatic spray system, an atomizer, a foam, a gel, using a vaporized sheet made of cellulose or plastic. Evaporator products, liquid evaporators, gel and membrane evaporators, screw-driven evaporators, energy-free or passive evaporation systems, insect-proof paper, insect-proof bags and insect-repellent glue, in the form of granules or dust particles. Used in the form of a spread bait or in a bait table.

製備實例：Preparation example: 實例I-6/I-8 Example I-6/I-8 2-[(4-氯苯基)羥基甲基]丙-2烯酸甲基酯2-[(4-Chlorophenyl)hydroxymethyl]prop-2-enoic acid methyl ester

取9.00g(63.83mmol)4-氯苯甲醛及10.99g(127.66mmol)丙-2烯酸甲基酯溶於250ml乙腈，添加5.51g(31.92mmol)1,4-重氮雙環[2.2.2]辛烷(DABCO)。反應混合物於室溫下攪拌2天。隨後，減壓蒸餾排除溶劑，殘質使用100ml水稀釋，及使用300ml乙酸乙酯萃取。溶液經硫酸鈉脫水，然後減壓蒸餾排除溶劑。殘質經管柱層析法，使用石油醚/乙酸乙酯(5：1)為溶離液純化。 9.00 g (63.83 mmol) of 4-chlorobenzaldehyde and 10.99 g (127.66 mmol) of propyl-2-enoic acid methyl ester were dissolved in 250 ml of acetonitrile, and 5.51 g (31.92 mmol) of 1,4-diazobicyclo[2. ] Octane (DABCO). The reaction mixture was stirred at room temperature for 2 days. Subsequently, the solvent was distilled off under reduced pressure, the residue was diluted with 100 ml of water, and extracted with 300 ml of ethyl acetate. The solution was dehydrated over sodium sulfate, and then the solvent was distilled off under reduced pressure. The residue was purified by column chromatography using petroleum ether / ethyl acetate (5:1).

(logP(HCOOH)：2.18；1H-NMR(400MHz,D6-DMSO)δ ppm：3.61(s,3H),5.42(d,1H),5.84(d,1H),6.00(s,1H),6.21(s,1H),7.30-7.38(m,4H). (logP(HCOOH): 2.18; 1 H-NMR (400MHz, D 6 -DMSO) δ ppm: 3.61 (s, 3H), 5.42 (d, 1H), 5.84 (d, 1H), 6.00 (s, 1H) , 6.21 (s, 1H), 7.30-7.38 (m, 4H).

(Z)-2-(溴甲基)-3-(4-氯苯基)丙-2烯酸甲基酯(Z)-2-(bromomethyl)-3-(4-chlorophenyl)prop-2-enoic acid methyl ester

在4.1g(19.3mmol)2-[(4-氯苯基)羥基甲基]丙-2烯酸甲基酯中添加20ml溴化氫之乙酸溶液，反應混合物於室溫下攪拌1h。隨後，減壓蒸餾排除溶劑，殘質使用60ml水稀釋及使用各200ml乙酸乙酯萃取2次。合併有機相，使用氯化鈉溶液洗滌，及經硫酸鈉脫水。溶液過濾，減壓蒸餾排除溶劑，殘質經管柱層析法，使用石油醚/乙酸乙酯梯度(20：1至5：1)為溶離液純化。 To 4.1 g (19.3 mmol) of 2-[(4-chlorophenyl)hydroxymethyl]prop-2-enoic acid methyl ester, 20 ml of a solution of hydrogen bromide in acetic acid was added, and the mixture was stirred at room temperature for 1 h. Subsequently, the solvent was distilled off under reduced pressure, and the residue was diluted with 60 ml of water and extracted twice with each 200 ml of ethyl acetate. The organic phases were combined, washed with a sodium chloride solution and dried over sodium sulfate. The solution was filtered, and the solvent was evaporated under reduced pressure. residue was purified by column chromatography using petroleum ether/ethyl acetate gradient (20:1 to 5:1).

(logP(HCOOH)：3.90；1H-NMR(400MHz,D6-丙酮)δ ppm：3.85(s,3H),4.47(s,2H),7.58(d,2H),7.68(d,2H),7.80(s,1H). (logP(HCOOH): 3.90; 1 H-NMR (400 MHz, D 6 -acetone) δ ppm: 3.85 (s, 3H), 4.47 (s, 2H), 7.58 (d, 2H), 7.68 (d, 2H) , 7.80 (s, 1H).

(Z)-3-(4-氯苯基)-2-(乙基硫基甲基)丙-2烯酸甲基酯(Z)-3-(4-Chlorophenyl)-2-(ethylthiomethyl)prop-2-enoic acid methyl ester

取6.5g(49.9mmol)二異丙基乙基胺加至含1.55g(24.9mmol)乙基甲硫醇及4.8g(16.7mmol)(Z)-2-(溴甲基)-3-(4-氯苯基)丙-2烯酸甲基酯之30ml二甲基甲醯胺(DMF)溶液中。反應混合物於室溫下攪拌一夜。隨後，溶液使用100ml水稀釋，及使用各250ml乙酸乙酯萃取2次。合併之有機相使用氯化鈉溶液洗滌，及經硫酸鈉脫水。溶液過濾，減壓蒸餾排除溶劑，產物直接進一步轉化。 6.5 g (49.9 mmol) of diisopropylethylamine was added to contain 1.55 g (24.9 mmol) of ethyl methyl mercaptan and 4.8 g (16.7 mmol) of (Z)-2-(bromomethyl)-3-( 4-Chlorophenyl)prop-2-enoic acid methyl ester in 30 ml of dimethylformamide (DMF) solution. The reaction mixture was stirred at room temperature overnight. Subsequently, the solution was diluted with 100 ml of water and extracted twice with 250 ml of each ethyl acetate. The combined organic phases were washed with a sodium chloride solution and dried over sodium sulfate. The solution was filtered, and the solvent was distilled off under reduced pressure, and the product was further directly transferred.

(Z)-3-(4-氯苯基)-2-(乙基硫基甲基)丙-2-烯酸(Z)-3-(4-chlorophenyl)-2-(ethylthiomethyl)prop-2-enoic acid

取4g(14.76mmol)(Z)-3-(4-氯苯基)-2-(乙基硫基甲基)丙-2烯酸甲基酯溶於20ml甲醇，添加20ml 2N氫氧化鈉溶液。反應混合物於室溫下攪拌12h。減壓蒸餾排除溶劑，殘質使用400ml水稀釋及使用濃鹽酸調至pH 3-4。隨後，反應混合物使用100ml氯仿/異丙醇(3：1)溶劑混合物萃取3次。合併之有機相經硫酸鈉脫水，及過濾，及減壓蒸餾排除溶劑。 Take 4g (14.76mmol) of (Z)-3-(4-chlorophenyl)-2-(ethylthiomethyl)prop-2-enoic acid methyl ester dissolved in 20ml of methanol, add 20ml 2N sodium hydroxide solution . The reaction mixture was stirred at room temperature for 12 h. The solvent was distilled off under reduced pressure, and the residue was diluted with 400 ml of water and adjusted to pH 3-4 using concentrated hydrochloric acid. Subsequently, the reaction mixture was extracted 3 times with 100 ml of a chloroform/isopropanol (3:1) solvent mixture. The combined organic phases were dried over sodium sulfate and filtered, and then evaporated and evaporated.

(logP(HCOOH)：3.15；1H-NMR(400MHz,D6-丙酮)δ ppm：1.20(t,3H),2.55(q,2H),3.66(s,2H),7.52(d,2H),7.65(d,2H),7.72(s,1H),11.00(br.s,1H). (logP(HCOOH): 3.15; 1 H-NMR (400MHz, D 6 -acetone) δ ppm: 1.20 (t, 3H), 2.55 (q, 2H), 3.66 (s, 2H), 7.52 (d, 2H) , 7.65 (d, 2H), 7.72 (s, 1H), 11.00 (br.s, 1H).

2-[(Z)-2-(4-氯苯基)-1-(乙基硫基甲基)乙烯基]-3-甲基-6-(三氟甲基)咪唑并[4,5-b]吡啶(I-6)2-[(Z)-2-(4-Chlorophenyl)-1-(ethylthiomethyl)vinyl]-3-methyl-6-(trifluoromethyl)imidazo[4,5 -b]pyridine (I-6)

取300mg(1.57mmol)N2-甲基-5-(三氟甲基)吡啶-2,3-二胺加至含400mg(1.57mmol)(Z)-3-(4-氯苯基)-2-(乙基硫基甲基)丙-2-烯酸及361 mg(1.88mmol)1-(3-二甲基胺基丙基)-3-乙基碳化二亞胺鹽酸鹽(EDCI)之6ml吡啶溶液中。反應混合物於80℃下攪拌2h。隨後，減壓蒸餾排除溶劑，殘質使用30ml水稀釋，使用50ml乙酸乙酯萃取，使用氯化鈉溶液洗滌，及經硫酸鈉脫水。溶液過濾，及減壓蒸餾排除溶劑，殘質溶於10ml乙酸，混合物於100℃下攪拌2h。減壓蒸餾排除溶劑，殘質使用30ml碳酸氫鈉水溶液稀釋及使用50ml乙酸乙酯萃取。有機相使用氯化鈉溶液洗滌，及經硫酸鈉脫水。減壓蒸餾排除溶劑，殘質經管柱層析法，使用乙腈/0.1%碳酸氫銨為溶離液純化。 300 mg (1.57 mmol) of N2-methyl-5-(trifluoromethyl)pyridine-2,3-diamine was added to contain 400 mg (1.57 mmol) of (Z)-3-(4-chlorophenyl)-2 -(ethylthiomethyl)prop-2-enoic acid and 361 mg (1.88 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) In 6 ml of pyridine solution. The reaction mixture was stirred at 80 ° C for 2 h. Subsequently, the solvent was distilled off under reduced pressure, and the residue was diluted with 30 ml of water, extracted with 50 ml of ethyl acetate, washed with sodium chloride and dried over sodium sulfate. The solution was filtered, and the solvent was evaporated under reduced pressure. residue was dissolved in 10 ml of acetic acid, and the mixture was stirred at 100 ° C for 2 h. The solvent was distilled off under reduced pressure, and the residue was diluted with 30 ml of aqueous sodium hydrogen carbonate and extracted with 50 ml of ethyl acetate. The organic phase was washed with a sodium chloride solution and dehydrated with sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by column chromatography using acetonitrile / 0.1% aqueous ammonium bicarbonate as a solvent.

(logP(HCOOH)：4.9；MH+：412；1H-NMR(300MHz,D6-DMSO)δ ppm：1.04(t,3H),2.45(q,2H),4.00(s,5H),7.29(s,1H),7.58-7.67(m,4H),8.55(s,1H),8.80(s,1H). (logP(HCOOH): 4.9; MH + : 412; 1 H-NMR (300MHz, D 6 - DMSO) δ ppm: 1.04 (t, 3H), 2.45 (q, 2H), 4.00 (s, 5H), 7.29 (s, 1H), 7.58-7.67 (m, 4H), 8.55 (s, 1H), 8.80 (s, 1H).

2-[(Z)-2-(4-氯苯基)-1-(乙基磺醯基甲基)乙烯基]-3-甲基-6-(三氟甲基)咪唑并[4,5-b]吡啶(I-8)2-[(Z)-2-(4-Chlorophenyl)-1-(ethylsulfonylmethyl)vinyl]-3-methyl-6-(trifluoromethyl)imidazo[4, 5-b]pyridine (I-8)

於0℃下，在含220mg(0.54mmol)2-[(Z)-2-(4-氯苯基)-1-(乙基硫基甲基)乙烯基]-3-甲基-6-(三氟甲基)-咪唑并[4,5-b]吡啶之20ml二氯甲烷溶液中添加368mg(2.14mmol)間氯過苯甲酸。反應混合物於0℃下攪拌2h。隨後，混合物使用50ml二氯甲烷稀釋，及使用20ml亞硫酸氫鈉水溶液洗滌。隨後，減壓蒸餾排除溶劑，殘質經管柱層析法，使用乙腈/0.1%碳酸氫銨為溶離液純化。 Containing 220 mg (0.54 mmol) of 2-[(Z)-2-(4-chlorophenyl)-1-(ethylthiomethyl)vinyl]-3-methyl-6- at 0 ° C 690 mg (2.14 mmol) of m-chloroperbenzoic acid was added to a solution of (trifluoromethyl)-imidazo[4,5-b]pyridine in 20 ml of dichloromethane. The reaction mixture was stirred at 0 ° C for 2 h. Subsequently, the mixture was diluted with 50 ml of dichloromethane and washed with 20 ml of an aqueous solution of sodium hydrogensulfite. Subsequently, the solvent was distilled off under reduced pressure, and the residue was purified by column chromatography using acetonitrile / 0.1% aqueous ammonium bicarbonate as a solvent.

(logP(HCOOH)：3.45；MH+：444；1H-NMR(300MHz,D6-DMSO)δ ppm：1.16(t,3H),3.14(q,2H),3.99(s,3H),4.71(s,2H),7.59-7.79(m,5H),8.53(s,1H),8.81(s,1H). (logP(HCOOH): 3.45; MH + : 444; 1 H-NMR (300MHz, D 6 - DMSO) δ ppm: 1.16 (t, 3H), 3.14 (q, 2H), 3.99 (s, 3H), 4.71 (s, 2H), 7.59-7.79 (m, 5H), 8.53 (s, 1H), 8.81 (s, 1H).

類似實例及依據上述製程，可能得到下列式(I)化合物： Similar examples and according to the above process, it is possible to obtain the following compounds of formula (I):

logP值係依據EEC Directive 79/831 Annex V.A8，採用HPLC(高效液相層析法)，使用逆相管柱(C18)測定。溫度：55℃。 The logP value was determined by HPLC (High Performance Liquid Chromatography) using a reverse phase column (C18) according to EEC Directive 79/831 Annex V.A8. Temperature: 55 ° C.

酸性範圍內之LC-MS測定法係在pH 2.7下，使用0.1%甲酸水溶 液及乙腈(含0.1%甲酸)作為溶離液，依10%乙腈至95%乙腈之線性梯度進行。表中以logP(HCOOH)表示。 The LC-MS assay in the acidic range was carried out at pH 2.7 using a 0.1% aqueous formic acid solution and acetonitrile (containing 0.1% formic acid) as the eluent, a linear gradient from 10% acetonitrile to 95% acetonitrile. The table is represented by logP (HCOOH).

採用具有已知logP-值之未分支之烷-2-酮類(具有3至16個碳原子)進行校正(在兩種連續烷酮之間使用滯留時間之線性內插法測定logP值)。 Calibration was performed using unbranched alkan-2-ones (having 3 to 16 carbon atoms) with known logP-values (logP values were determined using linear interpolation of residence time between two consecutive alkanones).

所選定實例之NMR數據NMR data for selected examples

所選定實例之NMR數據係依習用方式列表(δ值，裂峰多重性，氫原子數)或呈NMR波峰列表。 The NMR data for the selected examples are listed by convention (δ value, peak multiplicity, number of hydrogen atoms) or as a list of NMR peaks.

NMR光譜中記錄之溶劑係於各例中分別提示。 The solvents recorded in the NMR spectra are presented separately in each case.

NMR波峰列表方法NMR peak list method

所選定實例之1H NMR數據係以1H NMR-波峰列表型式出示。每個訊號峰先以δ值(ppm)表示，然後訊號強度則列於圓括號中。所列出不同訊號峰之每對δ值-訊號強度之間以分號作為分隔符號。 The 1H NMR data for the selected examples are presented as a 1H NMR-peak list. Each signal peak is first expressed in δ (ppm), and then the signal strength is listed in parentheses. Each pair of different signal peaks listed has a semicolon as a separator between the δ values and the signal strengths.

因此某一實例之波峰列表型式為：δ1(強度1)；δ2(強度2)；......；δi(強度i)；......；δn(強度n) Therefore, the peak list type of an example is: δ 1 (intensity 1 ); δ 2 (intensity 2 ); ...; δ i (intensity i ); ...; δ n (intensity n )

陡峰訊號強度係與印出之NMR光譜實例中訊號高度(以cm計)呈相關性，且顯示訊號強度之真實比例關係。在寬峰訊號中，則可出示複數個峰或中間訊號及其相較於光譜中最高強度訊號之相對強度。採用四甲基矽烷與/或溶劑之化學位移(尤其在DMSO中測定光譜時)校準1H NMR光譜之化學位移。因此四甲基矽烷峰有可能但不一定會出現在NMR波峰列表中。 The steep signal intensity is correlated with the height of the signal (in cm) in the printed NMR spectrum example and shows the true proportional relationship of the signal strength. In the wide-peak signal, a plurality of peaks or intermediate signals and their relative intensities relative to the highest intensity signal in the spectrum can be produced. The chemical shift of the 1H NMR spectrum was calibrated using chemical shifts of tetramethylnonane and/or solvent, especially when the spectrum was measured in DMSO. Therefore, the tetramethylnonane peak is possible but not necessarily present in the NMR peak list.

1H NMR波峰列表類似印出之典型1H NMR圖，因此通常包含列於典型NMR解讀中之所有波峰。 The 1H NMR peak list is similar to the typical 1H NMR map printed, and therefore typically contains all of the peaks listed in a typical NMR interpretation.

此外，可如同印出之典型1H NMR圖，其亦顯示溶劑訊號、目標化合物之立體異構物(其同樣形成本發明主題之一部份)訊號，及/或雜質之波峰。 In addition, as with the typical 1H NMR image printed, it also shows the solvent signal, the stereoisomer of the target compound (which also forms part of the subject matter of the invention), and/or the peak of the impurity.

在溶劑與/或水之δ-範圍內顯示化合物訊號時，吾等之1H NMR波峰列表會出示一般溶劑波峰(例如：DMSO-D6中之DMSO波峰)及水之 波峰，其通常以高強度平均值表示。 When the compound signal is displayed in the δ-range of solvent and/or water, our 1H NMR peak list will show the general solvent peak (eg DMSO peak in DMSO-D 6 ) and the water peak, which is usually high intensity. The average value is expressed.

目標化合物之立體異構物波峰與/或雜質波峰之平均強度通常低於目標化合物(例如：純度>90%)之波峰強度。 The average intensity of the stereoisomer peaks and/or impurity peaks of the target compound is generally lower than the peak intensity of the target compound (eg, purity >90%).

此等立體異構物與/或雜質係典型出現在特定製法中。因此其波峰有助於藉由「副產物指印」辨識吾等製法之再現性。 Such stereoisomers and/or impurities are typically found in a particular process. Therefore, its peak helps to identify the reproducibility of our system by means of "by-product fingerprints."

可以採用已知方法(MestreC，ACD-模擬法，但亦採用實驗性分析之預期數值)計算目標化合物波峰之專家可依需要另外採用其他強度濾波器，單離出目標化合物之波峰。此單離法即類似典型1H NMR解讀中相關波峰挑選法。 Experts who can use known methods (MestreC, ACD-simulation, but also use the expected values of experimental analysis) to calculate the peak of the target compound can additionally use other intensity filters to separate the peaks of the target compound. This singularity method is similar to the relevant peak selection method in a typical 1H NMR interpretation.

有關1H NMR波峰列表之進一步詳細內容可參見：Research Disclosure Database Number 564025。 Further details regarding the 1H NMR peak list can be found in Research Disclosure Database Number 564025.

應用實例Applications 貓櫛頭蚤(Ctenocephalides felis)-使用貓蚤成蟲之活體外接觸試驗Ctenocephalides felis - in vitro contact test using adult cat mites

塗佈試管時，先取9mg活性成份溶於1ml丙酮p.a.中，然後使用丙酮p.a.稀釋至所需濃度。取250μl溶液加至25ml玻璃試管中，藉由於環繞式振盪器上旋轉振盪而均勻分佈在內壁與底部(於30rpm下振盪旋轉2h)。在900ppm活性成份溶液與內表面積44.7cm2下，均勻分佈後可達到單位面積劑量為5μg/cm2。 When the test tube is coated, 9 mg of the active ingredient is first dissolved in 1 ml of acetone pa, and then diluted to the desired concentration with acetone pa. 250 μl of the solution was added to a 25 ml glass test tube and evenly distributed on the inner wall and the bottom (rotational rotation at 30 rpm for 2 h) due to rotational oscillation on the wraparound oscillator. 900ppm active ingredient in the inner surface area was 44.7cm 2, uniformly distributed can reach the area of the dosage unit of 5μg / cm 2.

蒸發排除溶劑後，在試管中接種5-10隻貓蚤成蟲(貓櫛頭蚤(Ctenocephalides felis))，使用多孔之塑膠蓋封口，呈水平位置於室溫及環境濕度下培養。48h後，測定效力。最後試管直立，被擊倒的貓蚤落在試管底部。留在底部不動或以不協調方式移動的貓蚤則視為死亡或垂死。 After evaporating to remove the solvent, 5-10 cat mites ( Ctenocephalides felis ) were inoculated in a test tube, sealed with a porous plastic cap, and cultured at a horizontal position at room temperature and ambient humidity. After 48 h, the potency was determined. Finally, the test tube was erect, and the knocked down cat fell to the bottom of the test tube. Meerkats that remain at the bottom or move in an uncoordinated manner are considered dead or dying.

本試驗中，在5μg/cm2施用率下，對貓櫛頭蚤(Ctenocephalides felis)若達到至少80%效力時，則該物質顯示良好效力。100%效力意指所有跳蚤均已死亡或垂死。0%效力意指沒有任何跳蚤受到傷害。 In this test, the substance showed good efficacy against Ctenocephalides felis at a rate of 5 μg/cm 2 if it reached at least 80% efficacy. 100% effectiveness means that all fleas are dead or dying. 0% effectiveness means no fleas are hurt.

本試驗中，例如：下列來自製備實例之化合物在5μg/cm2(=500g/ha)施用率下顯示100%效力：1、6、13 In this test, for example, the following compounds from the preparation examples show 100% efficacy at an application rate of 5 μg/cm 2 (=500 g/ha): 1, 6, 13

貓櫛頭蚤(Ctenocephalides felis)-口服試驗Ctenocephalides felis - oral test

溶劑：二甲亞碸 Solvent: dimethyl hydrazine

製備合適之活性成份調配物時，取10mg活性成份與0.5ml二甲亞碸混合。使用經過檸檬酸鹽處理之牛血稀釋至所需濃度。 When preparing a suitable active ingredient formulation, 10 mg of the active ingredient is mixed with 0.5 ml of dimethyl hydrazine. Dilute to the desired concentration using citrated bovine blood.

取約20隻未餵食之貓蚤成蟲(貓櫛頭蚤(Ctenocephalides felis))置入上下均用紗布封口之小箱中。將一個底部已使用石蠟膜封口之金屬量筒置於箱子上。量筒中包含血液/活性成份調配物，可讓跳蚤透過石蠟膜吸血。 About 20 unfed cat cockroaches ( Ctenocephalides felis ) were placed in a small box sealed with gauze. A metal measuring cylinder with a parafilm seal on the bottom is placed on the box. The cylinder contains a blood/active ingredient formulation that allows the flea to breathe through the parafilm.

兩天後，測定死亡率%。100%意指已殺死所有跳蚤；0%意指沒有殺死任何跳蚤。 Two days later, the % mortality was determined. 100% means that all fleas have been killed; 0% means that no fleas have been killed.

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示95%效力：8 In this test, for example, the following compounds from the preparation examples show 95% efficacy at 100 ppm application rate: 8

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示90%效力：6 In this test, for example, the following compounds from the preparation examples show 90% efficacy at 100 ppm application rate: 6

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示80%效力：1 In this test, for example, the following compounds from the preparation examples show 80% potency at 100 ppm application rate: 1

微小牛蜱(Boophilus microplus)-注射試驗Boophilus microplus - injection test

溶劑：二甲亞碸 Solvent: dimethyl hydrazine

製備合適之活性成份調配物時，取10mg活性成份與0.5ml溶劑混合，使用溶劑稀釋該濃縮液至所需濃度。 When preparing a suitable active ingredient formulation, 10 mg of the active ingredient is mixed with 0.5 ml of the solvent and the concentrate is diluted to the desired concentration using a solvent.

取1μl活性成份溶液注射至5隻已充血之雌性微小牛蜱(Boophilus microplus)成蟲腹部。將動物移至培養皿上，維持在人工氣候室內。 1 μl of the active ingredient solution was injected into the abdomen of five adult females of Boophilus microplus . The animals were transferred to a petri dish and maintained in an artificial climate chamber.

7天後，由所產下可孵化的卵來分析效力。將無法從目視觀察孵化性之卵存放在人工氣候室內，直到約42天後孵化為止。100%效力意指沒有任何牛蜱產下任何可孵化的卵；0%意指所有卵均可孵化。 After 7 days, the potency was analyzed from the eggs that were hatched. It is not possible to visually observe the hatching eggs in an artificial climate chamber until they hatch after about 42 days. 100% efficacy means that no burdock produces any hatchable eggs; 0% means that all eggs can hatch.

本試驗中，例如：下列來自製備實例之化合物在20μg/隻動物施用率下顯示80%效力：7 In this test, for example, the following compounds from the preparation examples showed 80% potency at an application rate of 20 μg/animal: 7

綿羊赤銅綠蠅(Lucilia cuprina)試驗Sheep Lucilia cuprina test

溶劑：二甲亞碸 Solvent: dimethyl hydrazine

製備合適之活性成份調配物時，取10mg活性成份與0.5ml二甲亞碸混合，使用水稀釋該濃縮液至所需濃度。 When preparing a suitable active ingredient formulation, 10 mg of the active ingredient is mixed with 0.5 ml of dimethyl hydrazine and the concentrate is diluted with water to the desired concentration.

取約20隻澳洲綿羊赤銅綠蠅(Lucilia cuprina)L1幼蟲移至包含碎 馬肉與所需濃度之活性成份調配物之試驗容器中。 Approximately 20 Australian sheep Lucilia cuprina L1 larvae were transferred to a test vessel containing ground horse meat and the active ingredient formulation at the desired concentration.

2天後，測定死亡率%。100%意指已殺死所有幼蟲；0%意指沒有殺死任何幼蟲。 After 2 days, the % mortality was determined. 100% means that all larvae have been killed; 0% means that no larvae have been killed.

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示100%效力：1、4、5、6、8、9、10、11、12、13、14、17、29 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 100 ppm application rate: 1, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 17, 29

家蠅(Musca domestica)試驗Musca domestica test

溶劑：二甲亞碸 Solvent: dimethyl hydrazine

製備合適之活性成份調配物時，取10mg活性成份與0.5ml二甲亞碸混合。加水稀釋該濃縮液至所需濃度。 When preparing a suitable active ingredient formulation, 10 mg of the active ingredient is mixed with 0.5 ml of dimethyl hydrazine. The concentrate was diluted with water to the desired concentration.

取10隻家蠅(Musca domestica)成蟲接種至包含已經過糖溶液與所需濃度之活性成份調配物處理之海綿之容器中。 Ten adult Musca domestica adults were inoculated into a container containing a sponge that had been treated with a sugar solution and a desired concentration of the active ingredient.

2天後，測定死亡率%。100%意指已殺死所有蠅；0%意指沒有殺死任何蠅。 After 2 days, the % mortality was determined. 100% means that all flies have been killed; 0% means that no flies have been killed.

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示100%效力：6、12、14、29 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 100 ppm application rate: 6, 12, 14, 29

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示90%效力：8 In this test, for example, the following compounds from the preparation examples show 90% efficacy at 100 ppm application rate: 8

本試驗中，例如：下列來自製備實例之化合物在100ppm施用率下顯示80%效力：1 In this test, for example, the following compounds from the preparation examples show 80% potency at 100 ppm application rate: 1

桃赤蚜(Myzus persicae)-口服試驗Myzus persicae - oral test

溶劑：100份重量比丙酮 Solvent: 100 parts by weight of acetone

製備合適之活性成份調配物時，使用指定份數重量比之溶劑溶解1份重量比活性成份，並補充水直到達到所需濃度為止。 When preparing a suitable active ingredient formulation, the active ingredient is dissolved in a specified ratio by weight of the solvent and the water is replenished until the desired concentration is reached.

取50μl活性成份製劑轉移至微滴定盤，使用150μl IPL41昆蟲培養基(33%+15%糖)補充至最終體積200μl。隨後，使用石蠟膜密封培養盤，石蠟膜可以讓第二個微滴定盤內之混齡桃赤蚜族群(Myzus persicae)穿刺並吸取該溶液。 50 μl of the active ingredient preparation was transferred to a microtiter plate and supplemented to a final volume of 200 μl using 150 μl of IPL41 insect medium (33% + 15% sugar). Subsequently, the culture plate is sealed with a parafilm, which allows the mixed group of Myzus persicae in the second microtiter plate to puncture and absorb the solution.

5天後，測定效力%。100%意指已殺死所有蚜蟲；0%意指沒有殺死任何蚜蟲。 After 5 days, the potency was determined. 100% means that all aphids have been killed; 0% means that no aphids have been killed.

本試驗中，例如：下列來自製備實例之化合物在20ppm施用率下 顯示100%效力：6、7、8、9、10、11、12、13、14、15、16、17、18、19、20、23、24 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 20 ppm application rate: 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 23, 24

本試驗中，例如：下列來自製備實例之化合物在20ppm施用率下顯示90%效力：5、22 In this test, for example, the following compounds from the preparation examples show 90% efficacy at an application rate of 20 ppm: 5, 22

本試驗中，例如：下列來自製備實例之化合物在4ppm施用率下顯示100%效力：6、7、8、9、12、16、17、25、27、29、31、32 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 4 ppm application rate: 6, 7, 8, 9, 12, 16, 17, 25, 27, 29, 31, 32

桃赤蚜(Myzus persicae)-噴灑試驗Myzus persicae - spray test

溶劑：78.0份重量比丙酮 Solvent: 78.0 parts by weight acetone

1.5份重量比二甲基甲醯胺 1.5 parts by weight of dimethylformamide

乳化劑：烷基芳基聚二醇醚 Emulsifier: alkyl aryl polyglycol ether

製備合適之活性成份調配物時，使用指定份數重量比之溶劑溶解1份重量比活性成份，並補充含1000ppm乳化劑濃度之水直到達到所需濃度為止。再使用含乳化劑之水稀釋該調配物，進一步製成其他試驗濃度。 When preparing a suitable active ingredient formulation, one part by weight of the active ingredient is dissolved using a specified portion by weight of the solvent, and water containing 1000 ppm of emulsifier concentration is added until the desired concentration is reached. The formulation was then diluted with water containing an emulsifier to further prepare other test concentrations.

在感染所有蟲齡之桃赤蚜(Myzus persicae)之捲心白菜(Brassica pekinensis)葉圓片上噴灑所需濃度之活性成份調配物。 The active ingredient formulation of the desired concentration is sprayed onto leaf discs of Brassica pekinensis infected with all of the larvae of Myzus persicae .

5-6天後，測定效力%。100%意指已殺死所有蚜蟲；0%意指沒有殺死任何蚜蟲。 After 5-6 days, the potency was determined. 100% means that all aphids have been killed; 0% means that no aphids have been killed.

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示100%效力：6、8、12、13、25、27 In this test, for example, the following compounds from the preparation examples show 100% efficacy at an application rate of 100 g/ha: 6, 8, 12, 13, 25, 27

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示90%效力：1、2、3、5、16、17、29 In this test, for example, the following compounds from the preparation examples show 90% efficacy at 100 g/ha application rate: 1, 2, 3, 5, 16, 17, 29

猿葉蟲(Phaedon cochleariae)-噴灑試驗Phaedon cochleariae - spray test

溶劑：78.0份重量比丙酮 Solvent: 78.0 parts by weight acetone

1.5份重量比二甲基甲醯胺 1.5 parts by weight of dimethylformamide

乳化劑：烷基芳基聚二醇醚 Emulsifier: alkyl aryl polyglycol ether

製備合適之活性成份調配物時，使用指定份數重量比之溶劑溶解1份重量比活性成份，並補充含1000ppm乳化劑濃度之水直到達到所需濃度為止。再使用含乳化劑之水稀釋該調配物，進一步製成其他試驗濃度。 When preparing a suitable active ingredient formulation, one part by weight of the active ingredient is dissolved using a specified portion by weight of the solvent, and water containing 1000 ppm of emulsifier concentration is added until the desired concentration is reached. The formulation was then diluted with water containing an emulsifier to further prepare other test concentrations.

以所需濃度之活性成份調配物噴灑捲心白菜(Brassica pekinensis)葉圓片，乾燥後，接種猿葉蟲(Phaedon cochleariae)幼蟲。 The leaves of Brassica pekinensis are sprayed with the active ingredient formulation at the desired concentration. After drying, the larvae of Phaedon cochleariae are inoculated.

7天後，測定效力%。100%意指已殺死所有猿葉蟲幼蟲；0%意指沒有殺死任何猿葉蟲幼蟲。 After 7 days, the potency % was determined. 100% means that all locust larvae have been killed; 0% means that no locust larvae have been killed.

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示100%效力：1、2、3、4、5、6、8、10、11、12、13、14、16、29 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 100 g/ha application rate: 1, 2, 3, 4, 5, 6, 8, 10, 11, 12, 13, 14, 16, 29

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示83%效力：20 In this test, for example, the following compounds from the preparation examples showed 83% efficacy at an application rate of 100 g/ha: 20

草地斜紋夜蛾(Spodoptera frugiperda)-噴灑試驗Spodoptera frugiperda - spray test

溶劑：78.0份重量比丙酮 Solvent: 78.0 parts by weight acetone

1.5份重量比二甲基甲醯胺 1.5 parts by weight of dimethylformamide

乳化劑：烷基芳基聚二醇醚 Emulsifier: alkyl aryl polyglycol ether

製備合適之活性成份調配物時，使用指定份數重量比之溶劑溶解1份重量比活性成份，並補充含1000ppm乳化劑濃度之水直到達到所需濃度為止。再使用含乳化劑之水稀釋該調配物，進一步製成其他試驗濃度。 When preparing a suitable active ingredient formulation, one part by weight of the active ingredient is dissolved using a specified portion by weight of the solvent, and water containing 1000 ppm of emulsifier concentration is added until the desired concentration is reached. The formulation was then diluted with water containing an emulsifier to further prepare other test concentrations.

在玉米(Zea mays)葉圓片上噴灑所需濃度之活性成份調配物，乾燥後，即接種草地斜紋夜蛾(Spodoptera frugiperda)幼蟲。7天後，測定效力%。100%意指已殺死所有幼蟲；0%意指沒有殺死任何幼蟲。 The active ingredient formulation of the desired concentration is sprayed on the corn leaf (Zea mays) leaves, and after drying, the larvae of Spodoptera frugiperda are inoculated. After 7 days, the potency % was determined. 100% means that all larvae have been killed; 0% means that no larvae have been killed.

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示100%效力：1、2、3、4、5、6、8、9、10、13、14、32、33本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示83%效力：11、12、29 In this test, for example, the following compounds from the preparation examples show 100% efficacy at 100 g/ha application rate: 1, 2, 3, 4, 5, 6, 8, 9, 10, 13, 14, 32, 33 In the test, for example, the following compounds from the preparation examples showed 83% efficacy at an application rate of 100 g/ha: 11, 12, 29

紅葉蟎(Tetranychus urticae)-噴灑試驗，OP-抗性Tetranychus urticae - spray test, OP-resistant

溶劑：78.0份重量比丙酮 Solvent: 78.0 parts by weight acetone

1.5份重量比二甲基甲醯胺 1.5 parts by weight of dimethylformamide

乳化劑：烷基芳基聚二醇醚 Emulsifier: alkyl aryl polyglycol ether

製備合適之活性成份調配物時，使用指定份數重量比之溶劑溶解1 份重量比活性成份，並補充含1000ppm乳化劑濃度之水直到達到所需濃度為止。再使用含乳化劑之水稀釋該調配物，進一步製成其他試驗濃度。 When preparing a suitable active ingredient formulation, the active ingredient is dissolved in a portion by weight of the solvent in a specified portion by weight and supplemented with water at a concentration of 1000 ppm emulsifier until the desired concentration is reached. The formulation was then diluted with water containing an emulsifier to further prepare other test concentrations.

在感染所有蟲齡溫室紅葉蟎(Tetranychus urticae)之菜豆(Phaseolus vulgaris)葉圓片上噴灑所需濃度之活性成份調配物。 The active ingredient formulation of the desired concentration is sprayed onto leaf disks of Phaseolus vulgaris infected with all of the insect-aged greenhouses of Tetranychus urticae .

6天後，測定效力%。100%意指已殺死所有蜘蛛蟎；0%意指沒有殺死任何蜘蛛蟎。 After 6 days, the potency was determined. 100% means that all spider mites have been killed; 0% means that no spider mites have been killed.

本試驗中，例如：下列來自製備實例之化合物在500g/ha施用率下顯示90%效力：2、3 In this test, for example, the following compounds from the preparation examples show 90% efficacy at an application rate of 500 g/ha: 2, 3

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示90%效力：2、6、15、16 In this test, for example, the following compounds from the preparation examples show 90% efficacy at an application rate of 100 g/ha: 2, 6, 15, 16

本試驗中，例如：下列來自製備實例之化合物在100g/ha施用率下顯示70%效力：4、5、19 In this test, for example, the following compounds from the preparation examples show 70% efficacy at an application rate of 100 g/ha: 4, 5, 19

Claims (17)

一種式(I)化合物 其中Q 為(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、(C 1-C 6)鹵烷基-(C 3-C 8)環烷基、(C 1-C 6)烷氧基-(C 3-C 8)環烷基、(C 1-C 6)鹵烷氧基-(C 3-C 8)環烷基、鹵(C 3-C 8)環烷基、氰基(C 3-C 8)環烷基，或於各情況下為視需要經相同或相異基團取代一次或多次之芳基或雜芳基，其中(以雜芳基為例)可視需要存在至少一個羰基，且其中於各情況下可能之取代基如下：氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF 5、三-(C 1-C 6)烷基矽基、(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、(C 1-C 6)鹵烷基-(C 3-C 8)環烷基、鹵-(C 3-C 8)環烷基、氰基-(C 3-C 8)環烷基、(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、羥基羰基-(C 1-C 6)-烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 2-C 6)烯基、(C 2-C 6)鹵烯基、(C 2-C 6)氰基烯基、(C 2-C 6)炔基、(C 2-C 6)鹵炔基、(C 2-C 6)氰基炔基、(C 1-C 6)烷氧基、(C 1-C 6)鹵烷氧基、(C 1-C 6)氰基烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基亞胺基、(C 1-C 6)鹵烷氧基亞胺基、(C 1-C 6)烷基硫基、(C 1-C 6)鹵烷基硫基、(C 1-C 6)烷氧基-(C 1-C 6)烷基硫基、(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷基亞磺醯基、(C 1-C 6)鹵烷基亞磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基亞磺醯基、(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基、 (C 1-C 6)鹵烷基磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基磺醯基、(C 1-C 6)烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基氧基、(C 1-C 6)鹵烷基磺醯基氧基、(C 1-C 6)烷基羰基、(C 1-C 6)鹵烷基羰基、(C 1-C 6)烷基羰基氧基、(C 1-C 6)烷氧基羰基、(C 1-C 6)鹵烷氧基羰基、胺基羰基、(C 1-C 6)烷基胺基羰基、二-(C 1-C 6)烷基胺基羰基、(C 1-C 6)鹵烷基胺基羰基、(C 2-C 6)烯基胺基羰基、二-(C 2-C 6)-烯基胺基羰基、(C 3-C 8)環烷基胺基羰基、(C 1-C 6)烷基磺醯基胺基、(C 1-C 6)烷基胺基、二-(C 1-C 6)烷基胺基、胺基磺醯基、(C 1-C 6)烷基胺基磺醯基、二-(C 1-C 6)烷基胺基磺醯基、(C 1-C 6)烷基亞碸亞胺基、胺基硫基羰基、(C 1-C 6)烷基胺基硫基羰基、二-(C 1-C 6)烷基胺基硫基羰基、(C 3-C 8)環烷基胺基、NHCO-(C 1-C 6)烷基、NHCO-(C 1-C 6)鹵烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)鹵烷基、NHCO-(C 1-C 6)環烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C 1-C 6)鹵烷基雜芳基或(C 1-C 6)鹵烷基側氧基雜芳基，R 6 為(C 1-C 6)烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基或(C 3-C 8)環烷基，R 7 為氫、(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 1-C 6)鹵烷氧基-(C 1-C 6)烷基、(C 2-C 6)烯基、(C 2-C 6)烯基氧-(C 1-C 6)烷基、(C 2-C 6)鹵烯基氧-(C 1-C 6)烷基、(C 2-C 6)鹵烯基、(C 2-C 6)氰基烯基、(C 2-C 6)炔基、(C 2-C 6)炔基氧-(C 1-C 6)烷基、(C 2-C 6)鹵炔基氧-(C 1-C 6)烷基、(C 2-C 6)鹵炔基、(C 2-C 6)氰基炔基、(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、鹵(C 3-C 8)環烷基、(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)鹵烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)鹵烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6) 烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)鹵烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基羰基-(C 1-C 6)烷基、(C 1-C 6)鹵烷基羰基-(C 1-C 6)烷基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷基或(C 1-C 6)鹵烷氧基羰基-(C 1-C 6)烷基，X 為選自H1至H15群中之雜芳族9-員或12-員稠合雙環或三環系統 R 8、R 9分別獨立為氫、氰基、鹵素、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、 (C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 3-C 6)環烷基、(C 3-C 6)環烷基-(C 3-C 6)環烷基、(C 1-C 4)烷基-(C 3-C 6)環烷基、(C 1-C 4)鹵烷基-(C 3-C 6)環烷基、氰基-(C 3-C 6)環烷基、鹵-(C 3-C 6)環烷基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 4)鹵烷氧基亞胺基(C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基磺醯基氧基、(C 1-C 4)鹵烷基磺醯基氧基、(C 1-C 4)烷基羰基、(C 1-C 4)鹵烷基羰基、胺基羰基、(C 1-C 4)烷基胺基羰基、二-(C 1-C 4)烷基-胺基羰基、(C 1-C 4)烷基磺醯基胺基、(C 1-C 4)烷基胺基、二-(C 1-C 4)烷基胺基、胺基磺醯基、(C 1-C 4)烷基胺基磺醯基或二-(C 1-C 4)烷基胺基磺醯基，R 10 為氫、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 1-C 4)氰基烷基、(C 1-C 4)羥基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 1-C 4)鹵烷氧基-(C 1-C 4)烷基、(C 2-C 4)烯基、(C 2-C 4)烯基氧-(C 1-C 4)烷基、(C 2-C 4)鹵烯基氧-(C 1-C 4)烷基、(C 2-C 4)鹵烯基、(C 2-C 4)氰基烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 3-C 6)環烷基，及n 為0、1或2，其中若X為H3時，n為1或2。 a compound of formula (I) Wherein Q is (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 - C 8 ) cycloalkyl, (C 1 -C 6 )haloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkoxy-(C 3 -C 8 )cycloalkyl (C 1 -C 6 ) haloalkoxy-(C 3 -C 8 )cycloalkyl, halo(C 3 -C 8 )cycloalkyl, cyano(C 3 -C 8 )cycloalkyl, or In each case, an aryl or heteroaryl group which is substituted one or more times by the same or a different group as desired, wherein (in the case of a heteroaryl group) at least one carbonyl group may optionally be present, and in each case possible The substituents are as follows: cyano group, carboxyl group, halogen, nitro group, ethyl hydrazine group, hydroxyl group, amine group, SCN, SF 5 , tris-(C 1 -C 6 )alkyl group, (C 3 -C 8 ) Cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 ) haloalkyl-(C 3 -C 8 )cycloalkyl, halo-(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl, (C 1 - C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl,hydroxycarbonyl-(C 1 -C 6 ) - alkoxy, (C 1 -C 6) alkoxycarbonyl - (C 1 -C 6) alkyl, (C 1 -C 6) alkoxy, - (C 1 -C 6) alkyl, (C 2 -C 6) alkenyl, (C 2 -C 6) halo Alkenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )halynynyl, (C 2 -C 6 )cyanoalkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 )alkoxycarbonyl-(C 1 - C 6 ) alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyimino, (C 1 -C 6 ) Haloalkoxyimino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, (C 1 -C 6 )alkoxy-(C 1 -C 6 An alkylthio group, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )halane Sulfosyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinylene, (C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 ) alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )haloalkylsulfonyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 ) Alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyloxy, (C 1 -C 6 ) haloalkyl sulfo acyl group, (C 1 -C 6) alkyl Carbonyl, (C 1 -C 6) haloalkyl carbonyl, (C 1 -C 6) alkylcarbonyloxy, (C 1 -C 6) alkoxycarbonyl, (C 1 -C 6) haloalkoxy Carbonyl group, aminocarbonyl group, (C 1 -C 6 )alkylaminocarbonyl group, bis-(C 1 -C 6 )alkylaminocarbonyl group, (C 1 -C 6 )haloalkylaminocarbonyl group, (C 2 -C 6 ) alkenylaminocarbonyl, bis-(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 )cycloalkylaminocarbonyl, (C 1 -C 6 )alkyl Sulfhydrylamino, (C 1 -C 6 )alkylamino, bis-(C 1 -C 6 )alkylamino, aminosulfonyl, (C 1 -C 6 )alkylaminosulfonate Mercapto, di-(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkyl sulfoximine, aminothiocarbonyl, (C 1 -C 6 )alkyl Aminothiocarbonyl, bis-(C 1 -C 6 )alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino, NHCO-(C 1 -C 6 )alkyl, NHCO- (C 1 -C 6 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 ) haloalkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, side Oxyheteroaryl, haloaryl, halooxyheteroaryl, cyanoheteroaryl a cyano-hydroxylheteroaryl group, a (C 1 -C 6 )haloalkylheteroaryl group or a (C 1 -C 6 )haloalkyl-tertiary heteroaryl group, and R 6 is (C 1 -C) 6 ) alkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, ( C 1 -C 6 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )haloalkyne Or (C 3 -C 8 )cycloalkyl, R 7 is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy-(C 1 -C 6 ) alkyl, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkenyloxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )haloenyloxy-(C 1- C 6 )alkyl, (C 2 -C 6 )haloenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )alkynyl Oxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )halynyloxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )halynyl, (C 2 -C 6 ) cyanoalkynyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl- (C 3 -C 8 )cycloalkyl, halo(C 3 -C 8 )cycloalkyl, (C 1 -C 6 Alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl -(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl-( C 1 -C 6 )alkyl, (C 1 -C 6 ) haloalkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 Alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 ) alkoxy-(C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylcarbonyl-(C 1 -C 6 ) alkyl, (C 1 -C 6 )haloalkylcarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxycarbonyl-(C 1 -C 6 )alkyl or C 1 -C 6 ) haloalkoxycarbonyl-(C 1 -C 6 )alkyl, X is a heteroaromatic 9-membered or 12-membered fused bicyclic or tricyclic system selected from the group H1 to H15 R 8 and R 9 are each independently hydrogen, cyano, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 - C 4 ) haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl- (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 ) Cycloalkyl, cyano-(C 3 -C 6 )cycloalkyl, halo-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )halide Alkoxy, (C 1 -C 4 ) alkoxyimino, (C 1 -C 4 ) haloalkoxyimino (C 1 -C 4 )alkylthio, (C 1 -C 4 a haloalkylthio group, a (C 1 -C 4 )alkylsulfinyl group, a (C 1 -C 4 )haloalkylsulfinyl group, a (C 1 -C 4 )alkylsulfonyl group, C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 An alkylcarbonyl group, (C 1 -C 4 )haloalkylcarbonyl group, an aminocarbonyl group, a (C 1 -C 4 )alkylaminocarbonyl group, a di-(C 1 -C 4 )alkyl-aminocarbonyl group, (C 1 -C 4) alkylsulfonyl amino group, (C 1 -C 4) alkylamino, di - (C 1 -C 4) alkylamino, amino sulfonic , (C 1 -C 4) alkylamino or di- sulfonic acyl - (C 1 -C 4) alkyl sulfonic acyl group, R 10 is hydrogen, (C 1 -C 4) -alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 ) Alkyl, (C 1 -C 4 ) haloalkoxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )alkenyloxy-(C 1 - C 4 )alkyl, (C 2 -C 4 )haloenyloxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )haloenyl, (C 2 -C 4 )cyanoalkenyl , (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3 -C 6 )cycloalkyl, and n is 0, 1 or 2, wherein if X is H3, n It is 1 or 2. 如請求項1之式(I)化合物，其中Q 為(C 3-C 6)環烷基、(C 3-C 6)環烷基-(C 3-C 6)環烷基、(C 1-C 6)烷基-(C 3-C 6)環烷基、(C 1-C 4)鹵烷基-(C 3-C 6)環烷基、鹵(C 3-C 6)環烷基，或於各情況下為視需要經相同或相異基團取代一次或多次之芳基或雜芳基，其中(以雜芳基為例)可視需要存在至少一個羰基，且其中於各情況下可能之取代基如下：氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF 5、三-(C 1-C 6)烷基矽基、(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、(C 1-C 6)鹵烷基-(C 3-C 8)環烷基、鹵-(C 3-C 8)環烷基、氰基-(C 3-C 8)環烷基、(C 1-C 6)烷基、(C 1-C 6) 鹵烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、羥基羰基-(C 1-C 6)-烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 2-C 6)烯基、(C 2-C 6)鹵烯基、(C 2-C 6)氰基烯基、(C 2-C 6)炔基、(C 2-C 6)鹵炔基、(C 2-C 6)氰基炔基、(C 1-C 6)烷氧基、(C 1-C 6)鹵烷氧基、(C 1-C 6)氰基烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基亞胺基、(C 1-C 6)鹵烷氧基亞胺基、(C 1-C 6)烷基硫基、(C 1-C 6)鹵烷基硫基、(C 1-C 6)烷氧基-(C 1-C 6)烷基硫基、(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷基亞磺醯基、(C 1-C 6)鹵烷基亞磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基亞磺醯基、(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基、(C 1-C 6)鹵烷基磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基磺醯基、(C 1-C 6)烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基氧基、(C 1-C 6)鹵烷基磺醯基氧基、(C 1-C 6)烷基羰基、(C 1-C 6)鹵烷基羰基、(C 1-C 6)烷基羰基氧基、(C 1-C 6)烷氧基羰基、(C 1-C 6)鹵烷氧基羰基、胺基羰基、(C 1-C 6)烷基胺基羰基、(C 1-C 6)鹵烷基胺基羰基、(C 2-C 6)烯基胺基羰基、二-(C 2-C 6)-烯基胺基羰基、(C 3-C 8)環烷基胺基羰基、(C 1-C 6)烷基磺醯基胺基、(C 1-C 6)烷基胺基、二-(C 1-C 6)烷基胺基、胺基磺醯基、(C 1-C 6)烷基胺基磺醯基、二-(C 1-C 6)烷基胺基磺醯基、(C 1-C 6)烷基亞碸亞胺基、胺基硫基羰基、(C 1-C 6)烷基胺基硫基羰基、二-(C 1-C 6)烷基胺基硫基羰基、(C 3-C 8)環烷基胺基、NHCO-(C 1-C 4)烷基、N(C 1-C 4)烷基-CO-(C 1-C 4)烷基、NHCO-(C 1-C 4)鹵烷基、N(C 1-C 4)烷基-CO-(C 1-C 4)鹵烷基、NHCO-(C 1-C 6)環烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C 1-C 6)鹵烷基雜芳基或(C 1-C 6)鹵烷基側氧基雜芳基，R 6 為(C 1-C 4)烷基、(C 1-C 4)氰基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4) 炔基、(C 2-C 4)鹵炔基或(C 3-C 6)環烷基，R 7 為氫、(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 1-C 6)鹵烷氧基-(C 1-C 6)烷基、(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、鹵(C 3-C 8)環烷基、(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)鹵烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)鹵烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基-(C 1-C 6)烷基或(C 1-C 6)鹵烷基磺醯基-(C 1-C 6)烷基，X 為選自H1、H2、H4、H5、H9、H11、H13、H14或H15之群中之雜芳族9-員或12-員稠合雙環或三環系統，R 8、R 9分別獨立為氫、氰基、鹵素、(C 1-C 4)-烷基、(C 1-C 4)-鹵烷基、(C 2-C 4)-烯基、(C 2-C 4)-鹵烯基、(C 2-C 4)-炔基、(C 2-C 4)-鹵炔基、(C 3-C 6)-環烷基、(C 3-C 6)-環烷基-(C 3-C 6)-環烷基、(C 1-C 4)-烷基-(C 3-C 6)-環烷基、(C 1-C 4)鹵烷基-(C 3-C 6)環烷基、氰基-(C 3-C 6)環烷基、鹵-(C 3-C 6)環烷基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 4)鹵烷氧基亞胺基、(C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基磺醯基氧基、(C 1-C 4)鹵烷基磺醯基氧基、(C 1-C 4)烷基羰基或(C 1-C 4)鹵烷基羰基，R 10 為氫、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 1-C 4)氰基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 1-C 4)鹵烷氧基-(C 1-C 4)烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基或(C 3-C 6)環烷基，及n 為0、1或2。 A compound of the formula (I) according to claim 1, wherein Q is (C 3 -C 6 )cycloalkyl, (C 3 -C 6 )cycloalkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkane Or, in each case, an aryl or heteroaryl group substituted one or more times by the same or a different group as desired, wherein (in the case of a heteroaryl group) at least one carbonyl group may optionally be present, and Where possible substituents are as follows: cyano, carboxy, halo, nitro, ethyl hydrazine, hydroxy, amine, SCN, SF 5 , tris-(C 1 -C 6 )alkyl fluorenyl, (C 3 - C 8 ) cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )haloalkyl-(C 3 -C 8 )cycloalkyl, halo-(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl, ( C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, hydroxycarbonyl-(C 1 - C 6 )-alkoxy, (C 1 -C 6 ) alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl , (C 2 -C 6 )alkenyl, (C 2 -C 6 )haloalkenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )halynyl,(C 2 -C 6 )cyanide Alkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 )alkoxy Carbonyl-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxyimino, ( C 1 -C 6 ) haloalkoxyimino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, (C 1 -C 6 )alkoxy- (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 ) haloalkylsulfinyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfinyl -(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 ) haloalkylsulfonyl, (C 1 -C 6 )alkoxy-( C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyloxy, (C 1 -C 6 ) haloalkylsulfonyloxy, (C 1 -C 6 )alkylcarbonyl, (C 1 -C 6 )haloalkylcarbonyl, (C 1 -C 6 )alkylcarbonyloxy Base, (C 1 -C 6 ) alkane Oxycarbonyl, (C 1 -C 6 )haloalkoxycarbonyl, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 )haloalkylaminocarbonyl, (C 2 -C 6 ) alkenylaminocarbonyl, bis-(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 )cycloalkylaminocarbonyl, (C 1 -C 6 )alkyl Sulfhydrylamino, (C 1 -C 6 )alkylamino, bis-(C 1 -C 6 )alkylamino, aminosulfonyl, (C 1 -C 6 )alkylaminosulfonate Mercapto, di-(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkyl sulfoximine, aminothiocarbonyl, (C 1 -C 6 )alkyl Aminothiocarbonyl, bis-(C 1 -C 6 )alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino, NHCO-(C 1 -C 4 )alkyl, N ( C 1 -C 4 )alkyl-CO-(C 1 -C 4 )alkyl, NHCO-(C 1 -C 4 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 ) haloalkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, side Oxyheteroaryl, haloaryl, halooxyheteroaryl, cyanoheteroaryl, cyanoyloxyheteroaryl, (C 1 -C 6 )haloalkylheteroaryl or (C 1 -C 6 ) haloalkyl-tertiary heteroaryl, R 6 is (C 1 -C 4 An alkyl group, (C 1 -C 4 ) cyanoalkyl group, (C 1 -C 4 ) alkoxy-(C 1 -C 4 )alkyl group, (C 1 -C 4 )haloalkyl group, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynyl or (C 3 -C 6 )cycloalkyl R 7 is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 )cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, (C 1 -C 6 ) alkoxy-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkoxy-(C 1 -C 6 )alkyl, (C 3 -C 8 ) Cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, halogen (C 3- C 8 )cycloalkyl, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylsulfide-(C 1 -C 6 ) alkane (C 1 -C 6 )alkylsulfinyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkylsulfinyl-(C 1 -C 6 )alkyl (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl or (C 1 -C 6 ) haloalkylsulfonyl-(C 1 -C 6 )alkyl, X is a heteroaromatic 9-member or 12-membered fused bicyclic or tricyclic ring system selected from the group consisting of H1, H2, H4, H5, H9, H11, H13, H14 or H15, wherein R 8 and R 9 are each independently hydrogen , cyano, halogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-haloalkyl, (C 2 -C 4 )-alkenyl, (C 2 -C 4 )-haloalkenyl, (C 2 -C 4 )-alkyne , (C 2 -C 4 )-haloalkynyl, (C 3 -C 6 )-cycloalkyl, (C 3 -C 6 )-cycloalkyl-(C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )-alkyl-(C 3 -C 6 )-cycloalkyl, (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, cyano-(C 3- C 6 )cycloalkyl, halo-(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 ) alkoxyimido group, (C 1 -C 4 )haloalkoxyimino group, (C 1 -C 4 )alkylthio group, (C 1 -C 4 )haloalkylthio group, ( C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 )halane Sulfosyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 )alkylcarbonyl or (C 1 -C 4 ) haloalkylcarbonyl, R 10 is hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 ) alkoxy-(C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkoxy-(C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 ) haloalkynyl or (C 3 -C 6 )cycloalkyl, and n is 0, 1 or 2. 如請求項1之式(I)化合物，其中Q 為(C 3-C 6)環烷基或於各情況下視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒 、噻吩、呋喃、吡唑、噻唑、噁唑、咪唑或咪唑并吡啶，其中於各情況下 可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、SF 5-、(C 3-C 6)環烷基、(C 1-C 4)烷基-(C 3-C 6)環烷基、鹵(C 3-C 6)環烷基、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 1-C 4)氰基烷基、(C 1-C 4)羥基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)氰基烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 2-C 4)氰基炔基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)氰基烷氧基、(C 1-C 4)烷氧基-(C 1-C 4)烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 6)鹵烷氧基亞胺基、(C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基硫-(C 1-C 4)烷基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基磺醯基氧基、(C 1-C 4)鹵烷基磺醯基氧基、(C 1-C 4)烷基羰基、(C 1-C 4)鹵烷基羰基、胺基羰基、胺基硫基羰基、(C 1-C 4)烷基胺基羰基、(C 1-C 4)鹵烷基胺基羰基、二-(C 1-C 4)烷基胺基羰基、(C 1-C 4)烷基磺醯基胺基、(C 1-C 4)烷基胺基、二-(C 1-C 4)烷基胺基、胺基磺醯基、(C 1-C 4)烷基胺基磺醯基、二-(C 1-C 4)烷基胺基磺醯基、NHCO-(C 1-C 4)烷基、N(C 1-C 4)烷基-CO-(C 1-C 4)烷基、NHCO-(C 1-C 6)環烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C 1-C 4)鹵烷基雜芳基或(C 1-C 4)鹵烷基側氧基雜芳基，R 6 為(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基或(C 3-C 4)環烷基，R 7 為氫、(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 3-C 6)環烷基或鹵(C 3-C 6)環烷基，X 為選自H1、H2、H9、H11、H13或H15群中之雜芳族9-員或12-員稠合雙環或三環系統，R 8 為鹵素、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 3-C 6)環烷基、(C 1-C 4)鹵烷基-(C 3-C 6)環烷基、氰基-(C 3-C 6)環烷基、鹵-(C 3-C 6)環 烷基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 4)鹵烷氧基亞胺基、(C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基磺醯基氧基、(C 1-C 4)鹵烷基磺醯基氧基、(C 1-C 4)烷基羰基或(C 1-C 4)鹵烷基羰基，R 9 為氫、氰基、鹵素、(C 1-C 4)烷基、(C 1-C 4)鹵烷基或(C 3-C 6)環烷基，R 10 為氫、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 1-C 4)烷氧基-(C 1-C 4)烷基或(C 3-C 6)環烷基，及n 為0、1或2。 A compound of the formula (I) according to claim 1, wherein Q is (C 3 -C 6 )cycloalkyl or, in each case, substituted phenyl, pyridine or pyrimidine one or more times by the same or a different group, if necessary ,despair , thiophene, furan, pyrazole, thiazole, oxazole, imidazole or imidazopyridine, wherein in each case possible substituents are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxyl, amine, SF 5 - (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy- (C 1 -C 4 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )cyanoalkenyl, (C 2 -C 4 ) Alkynyl, (C 2 -C 4 )halynynyl, (C 2 -C 4 )cyanoalkynyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, ( C 1 -C 4 ) cyanoalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 6 ) haloalkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 )alkylthio-( C 1 -C 4 )alkyl, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl , (C 1 -C 4) halo alkylsulfonyl group, (C 1 -C 4) alkylsulfonyl oxy group (C 1 -C 4) haloalkyl sulfo acyl group, (C 1 -C 4) alkylcarbonyl, (C 1 -C 4) haloalkyl carbonyl, aminocarbonyl, amino thiocarbonyl group, ( C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )haloalkylaminocarbonyl, di-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkyl Sulfhydrylamino, (C 1 -C 4 )alkylamino, bis-(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonate Mercapto, di-(C 1 -C 4 )alkylaminosulfonyl, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 ) alkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant oxy Aryl, haloaryl, halooxyheteroaryl, cyanoheteroaryl, cyanoyloxyheteroaryl, (C 1 -C 4 )haloalkylheteroaryl or (C 1 -C 4 ) a haloalkyl-tertiary heteroaryl group, R 6 is (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, (C 2 -C 4 )alkenyl, (C 2 - C 4 ) haloalkenyl or (C 3 -C 4 )cycloalkyl, R 7 is hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 3 -C 6 a cycloalkyl or halo(C 3 -C 6 )cycloalkyl group, X being selected from the group consisting of H1, H2, H9, H11, H13 Or a heteroaromatic 9- or 12-membered fused bicyclic or tricyclic ring system of the H15 group, R 8 being halo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, C 2 -C 4 )alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, (C 3 -C 6 )cycloalkane , (C 1 -C 4 )haloalkyl-(C 3 -C 6 )cycloalkyl, cyano-(C 3 -C 6 )cycloalkyl, halo-(C 3 -C 6 )cycloalkyl (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxyimino, (C 1 -C 4 )halo alkoxy Amine group, (C 1 -C 4 )alkylthio group, (C 1 -C 4 )haloalkylthio group, (C 1 -C 4 )alkylsulfinyl group, (C 1 -C 4 )halide Alkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, ( C 1 -C 4 ) haloalkylsulfonyloxy, (C 1 -C 4 )alkylcarbonyl or (C 1 -C 4 )haloalkylcarbonyl, R 9 is hydrogen, cyano, halogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl or (C 3 -C 6 )cycloalkyl, R 10 is hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4) haloalkyl, (C 2 -C 4) alkenyl, (C 2 -C 4) haloalkenyl, (C 2 -C 4) alkynyl, (C 2 -C 4) haloalkynyl (C 1 -C 4) alkoxy, - (C 1 -C 4) alkyl or (C 3 -C 6) cycloalkyl group, and n is 0, 1 or 2. 如請求項1之式(I)化合物，其中Q 為環丙基或於各情況下視需要經相同或相異基團取代一次或多次之苯基、吡啶、嘧啶、嗒 、噻吩、噻唑、噁唑、咪唑或咪唑并[1,2-a]吡啶，其中於各情況下可能之取代基如下：氰基、鹵素、硝基、乙醯基、羥基、胺基、(C 3-C 6)環烷基、(C 1-C 4)烷基-(C 3-C 6)環烷基、鹵(C 3-C 6)環烷基、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 1-C 4)氰基烷基、(C 1-C 4)羥基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)烷氧基-(C 1-C 4)烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基羰基、胺基羰基、胺基硫基羰基、(C 1-C 4)烷基胺基羰基、二-(C 1-C 4)烷基胺基羰基、(C 1-C 4)烷基磺醯基胺基、(C 1-C 4)烷基胺基、二(C 1-C 4)烷基胺基、胺基磺醯基、(C 1-C 4)烷基胺基磺醯基、二(C 1-C 4)烷基胺基磺醯基、吡唑基或鹵素取代之吡唑基，R 6 為甲基、乙基、正丙基、異丙基、環丙基、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙 基或五氟乙基，R 7 為氫、甲基、乙基、正丙基、異丙基、環丙基、正丁基、異丁基、第三丁基、環丁基、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙基或五氟乙基，X 為H1、H2、H9、H11、H13或H15，R 8 為氟、氯、氟甲基、二氟甲基、三氟甲基、氟乙基、二氟乙基、三氟乙基、四氟乙基、五氟乙基、三氟甲氧基、二氟氯甲氧基、二氯氟甲氧基、三氟甲基硫基、三氟甲基磺醯基或三氟甲基亞磺醯基，R 9 為氫，R 10 為甲基、乙基、正丙基、異丙基、正丁基、異丁基、第三丁基、甲氧基甲基或甲氧基乙基，及n 為0、1或2。 A compound of the formula (I) according to claim 1 wherein Q is cyclopropyl or, in each case, substituted phenyl, pyridine, pyrimidine or pyrene, one or more times by the same or a different group, if desired. , thiophene, thiazole, oxazole, imidazole or imidazo[1,2-a]pyridine, wherein in each case possible substituents are as follows: cyano, halogen, nitro, ethyl hydrazine, hydroxy, amine, ( C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 ) Alkyl, (C 1 -C 4 )haloalkyl, (C 1 -C 4 )cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1- C 4 )alkyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )alkoxy-(C 1 -C 4 ) alkane Oxyl, (C 1 -C 4 ) alkoxyimino, (C 1 -C 4 )alkylthio, (C 1 -C 4 )haloalkylthio, (C 1 -C 4 ) alkane (i-sulfonyl), (C 1 -C 4 ) haloalkylsulfinyl, (C 1 -C 4 )alkylsulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, bis-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino, (C 1 -C 4 )alkylamino, bis(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 ) sulfo acyl alkylamino, di (C 1 -C 4) alkylamine Sulfo acyl, the substituted pyrazol-pyrazolyl group or a halogen, R 6 is methyl, ethyl, n-propyl, isopropyl, cyclopropyl, fluoromethyl, difluoromethyl, trifluoromethyl, Fluoroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl or pentafluoroethyl, R 7 is hydrogen, methyl, ethyl, n-propyl, isopropyl, cyclopropyl, n-butyl , isobutyl, tert-butyl, cyclobutyl, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl or pentafluoroethyl Base, X is H1, H2, H9, H11, H13 or H15, and R 8 is fluorine, chlorine, fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl , tetrafluoroethyl, pentafluoroethyl, trifluoromethoxy, difluorochloromethoxy, dichlorofluoromethoxy, trifluoromethylthio, trifluoromethylsulfonyl or trifluoromethyl Sulfosyl, R 9 is hydrogen, R 10 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, methoxymethyl or methoxy Base, and n is 0, 1, or 2. 如請求項1之式(I)化合物，其中Q 為環丙基或未經取代或經相同或相異之單-或二-氯-、-三氟甲基-或-4-氯吡唑-取代之苯基、吡啶、噻唑或咪唑并[1,2-a]吡啶，R 6 為甲基或乙基，R 7 為氫，X 為H1或H2，R 8 為三氟甲基，R 9 為氫，R 10 為甲基，及n 為0、1或2。 A compound of formula (I) according to claim 1 wherein Q is cyclopropyl or unsubstituted or the same or different mono- or di-chloro-, -trifluoromethyl- or 4-chloropyrazole- Substituted phenyl, pyridine, thiazole or imidazo[1,2-a]pyridine, R 6 is methyl or ethyl, R 7 is hydrogen, X is H 1 or H 2 , R 8 is trifluoromethyl, R 9 Is hydrogen, R 10 is methyl, and n is 0, 1 or 2. 如請求項1至4中任一項之式(I)化合物，其特徵在於X為H1、H2、H15或H13。  A compound of the formula (I) according to any one of claims 1 to 4, characterized in that X is H1, H2, H15 or H13.   如請求項1至6中任一項之式(I-A)化合物 其中X、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5或請求項6之定義，及A 1 為氮、=N +(O -)-或=C(R 1)-，A 2 為氮、=N +(O -)-或=C(R 2)-，A 3 為氮、=N +(O -)-或=C(R 3)-，A 4 為氮、=N +(O -)-或=C(R 4)-，A 5 為氮、=N +(O -)-或=C(R 5)-，其中A 1、A 2、A 3、A 4及A 5之群中不超過兩個基為氮，及A 1、A 2、A 3、A 4及A 5之群中不超過一個基為=N +(O -)，及R 1、R 2、R 3、R 4及R 5分別獨立為氫、氰基、羧基、鹵素、硝基、乙醯基、羥基、胺基、SCN、SF 5、三-(C 1-C 6)烷基矽基、(C 3-C 8)環烷基、(C 3-C 8)環烷基-(C 3-C 8)環烷基、(C 1-C 6)烷基-(C 3-C 8)環烷基、(C 1-C 6)鹵烷基-(C 3-C 8)環烷基、鹵-(C 3-C 8)環烷基、氰基-(C 3-C 8)環烷基、(C 1-C 6)烷基、(C 1-C 6)鹵烷基、(C 1-C 6)氰基烷基、(C 1-C 6)羥基烷基、羥基羰基-(C 1-C 6)-烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷基、(C 1-C 6)烷氧基-(C 1-C 6)烷基、(C 2-C 6)烯基、(C 2-C 6)鹵烯基、(C 2-C 6)氰基烯基、(C 2-C 6)炔基、(C 2-C 6)鹵炔基、(C 2-C 6)氰基炔基、(C 1-C 6)烷氧基、(C 1-C 6)鹵烷氧基、(C 1-C 6)氰基烷氧基、(C 1-C 6)烷氧基羰基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基-(C 1-C 6)烷氧基、(C 1-C 6)烷氧基亞胺基、(C 1-C 6)鹵烷氧基亞胺基、(C 1-C 6)烷基硫基、(C 1-C 6)鹵烷基硫基、(C 1-C 6)烷氧基-(C 1-C 6)烷基硫基、(C 1-C 6)烷基硫-(C 1-C 6)烷基、(C 1-C 6)烷基亞磺醯基、(C 1-C 6)鹵烷基亞磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基亞磺醯基、(C 1-C 6)烷基亞磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基、(C 1-C 6)鹵烷基磺醯基、(C 1-C 6)烷氧基-(C 1-C 6)烷基磺醯基、(C 1-C 6)烷基磺醯基-(C 1-C 6)烷基、(C 1-C 6)烷基磺醯基氧基、(C 1-C 6)鹵烷基磺醯基氧基、(C 1-C 6)烷基羰基、(C 1-C 6)鹵烷基羰基、(C 1-C 6)烷基羰基氧基、(C 1-C 6)烷氧基羰基、(C 1-C 6)鹵烷氧基羰基、 胺基羰基、(C 1-C 6)烷基胺基羰基、二-(C 1-C 6)烷基胺基羰基、(C 1-C 6)鹵烷基胺基羰基、(C 2-C 6)烯基胺基羰基、二-(C 2-C 6)-烯基胺基羰基、(C 3-C 8)環烷基胺基羰基、(C 1-C 6)烷基磺醯基胺基、(C 1-C 6)烷基胺基、二-(C 1-C 6)烷基胺基、胺基磺醯基、(C 1-C 6)烷基胺基磺醯基、二-(C 1-C 6)烷基胺基磺醯基、(C 1-C 6)烷基亞碸亞胺基、胺基硫基羰基、(C 1-C 6)烷基胺基硫基羰基、二-(C 1-C 6)烷基胺基硫基羰基、(C 3-C 8)環烷基胺基、NHCO-(C 1-C 6)烷基、NHCO-(C 1-C 6)鹵烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)鹵烷基、NHCO-(C 1-C 6)環烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C 1-C 6)鹵烷基雜芳基或(C 1-C 6)鹵烷基側氧基雜芳基。 A compound of formula (IA) according to any one of claims 1 to 6 Wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions of claim 1 or claim 2 or claim 3 or claim 4 or claim 5 or claim 6, and A 1 Is nitrogen, =N + (O - )- or =C(R 1 )-, A 2 is nitrogen, =N + (O - )- or =C(R 2 )-, A 3 is nitrogen, =N + (O - )- or =C(R 3 )-, A 4 is nitrogen, =N + (O - )- or =C(R 4 )-, A 5 is nitrogen, =N + (O - )- or = C (R 5) -, wherein the group A 1, A 2, A 3 , A 4 and A 5 of no more than two groups is nitrogen, and A 1, A 2, A 3 , A 4 and A 5 of No more than one group in the group is =N + (O - ), and R 1 , R 2 , R 3 , R 4 and R 5 are each independently hydrogen, cyano, carboxyl, halogen, nitro, ethylidene, hydroxy , amine, SCN, SF 5 , tris-(C 1 -C 6 )alkylfluorenyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl-(C 3 -C 8 ) cycloalkyl, (C 1 -C 6 )alkyl-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )haloalkyl-(C 3 -C 8 )cycloalkyl, halogen -(C 3 -C 8 )cycloalkyl, cyano-(C 3 -C 8 )cycloalkyl, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, (C 1 -C 6 ) cyanoalkyl, (C 1 -C 6 )hydroxyalkyl, hydroxycarbonyl-(C 1 -C 6 )-alkoxy, (C 1 - C 6 ) alkoxycarbonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, ( C 2 -C 6 )haloalkenyl, (C 2 -C 6 )cyanoalkenyl, (C 2 -C 6 )alkynyl, (C 2 -C 6 )halynynyl, (C 2 -C 6 ) Cyanoalkynyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )haloalkoxy, (C 1 -C 6 )cyanoalkoxy, (C 1 -C 6 )alkoxy a carbonyl-(C 1 -C 6 )alkoxy group, a (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkoxy group, a (C 1 -C 6 ) alkoxyimino group, (C 1 -C 6 ) haloalkoxyimino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )haloalkylthio, (C 1 -C 6 )alkoxy -(C 1 -C 6 )alkylthio, (C 1 -C 6 )alkylthio-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfinyl, (C 1- C 6 ) haloalkylsulfinyl, (C 1 -C 6 )alkoxy-(C 1 -C 6 )alkylsulfinyl, (C 1 -C 6 )alkylsulfinium -(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )haloalkylsulfonyl, (C 1 -C 6 )alkoxy- (C 1 -C 6 )alkylsulfonyl, (C 1 -C 6 )alkylsulfonyl-(C 1 -C 6 )alkyl, (C 1 -C 6 )alkylsulfonyloxy (C 1 -C 6 ) haloalkylsulfonyloxy (C 1 -C 6 )alkylcarbonyl, (C 1 -C 6 )haloalkylcarbonyl, (C 1 -C 6 )alkylcarbonyloxy, (C 1 -C 6 )alkoxycarbonyl, C 1 -C 6 )haloalkoxycarbonyl, aminocarbonyl, (C 1 -C 6 )alkylaminocarbonyl, bis-(C 1 -C 6 )alkylaminocarbonyl, (C 1 -C 6 Haloalkylaminocarbonyl, (C 2 -C 6 )alkenylaminocarbonyl, bis-(C 2 -C 6 )-alkenylaminocarbonyl, (C 3 -C 8 )cycloalkylaminocarbonyl (C 1 -C 6 )alkylsulfonylamino, (C 1 -C 6 )alkylamino, bis-(C 1 -C 6 )alkylamino, aminosulfonyl, (C 1 -C 6 )alkylaminosulfonyl, bis-(C 1 -C 6 )alkylaminosulfonyl, (C 1 -C 6 )alkylfluorenylene, aminothiocarbonyl (C 1 -C 6 )alkylaminothiocarbonyl, bis-(C 1 -C 6 )alkylaminothiocarbonyl, (C 3 -C 8 )cycloalkylamino, NHCO-(C 1 -C 6 )alkyl, NHCO-(C 1 -C 6 )haloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )alkyl, N(C 1 -C 4 ) alkyl-CO-(C 1 -C 6 )haloalkyl, NHCO-(C 1 -C 6 )cycloalkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 a cycloalkyl, heteroaryl, pendant heteroaryl, haloaryl, halooxy Group, a cyano heteroaryl, heteroaryl pendant cyano group, (C 1 -C 6) haloalkyl or heteroaryl (C 1 -C 6) haloalkyl oxo heteroaryl. 如請求項7之式(I-A)化合物，其中X、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5或請求項6之定義，及A 1 為氮或=C(R 1)，A 2 為氮或=C(R 2)，A 3 為氮或=C(R 3)，A 4 為氮或=C(R 4)，A 5 為氮或=C(R 5)，其中A 1、A 2、A 3、A 4及A 5之群中不超過兩個基為氮，及R 1、R 2、R 3、R 4及R 5分別獨立為氫、氰基、鹵素、硝基、乙醯基、羥基、胺基、SF 5-、(C 3-C 6)環烷基、(C 1-C 4)烷基-(C 3-C 6)環烷基、鹵(C 3-C 6)環烷基、(C 1-C 4)烷基、(C 1-C 4)鹵烷基、(C 1-C 4)氰基烷基、(C 1-C 4)羥基烷基、(C 1-C 4)烷氧基-(C 1-C 4)烷基、(C 2-C 4)烯基、(C 2-C 4)鹵烯基、(C 2-C 4)氰基烯基、(C 2-C 4)炔基、(C 2-C 4)鹵炔基、(C 2-C 4)氰基炔基、(C 1-C 4)烷氧基、(C 1-C 4)鹵烷氧基、(C 1-C 4)氰基烷氧基、(C 1-C 4)烷氧基-(C 1-C 4)烷氧基、(C 1-C 4)烷氧基亞胺基、(C 1-C 6)鹵烷氧基亞胺基、 (C 1-C 4)烷基硫基、(C 1-C 4)鹵烷基硫基、(C 1-C 4)烷基硫-(C 1-C 4)烷基、(C 1-C 4)烷基亞磺醯基、(C 1-C 4)鹵烷基亞磺醯基、(C 1-C 4)烷基磺醯基、(C 1-C 4)鹵烷基磺醯基、(C 1-C 4)烷基磺醯基氧基、(C 1-C 4)鹵烷基磺醯基氧基、(C 1-C 4)烷基羰基、(C 1-C 4)鹵烷基羰基、胺基羰基、胺基硫基羰基、(C 1-C 4)烷基胺基羰基、(C 1-C 4)鹵烷基胺基羰基、二-(C 1-C 4)烷基胺基羰基、(C 1-C 4)烷基磺醯基胺基、(C 1-C 4)烷基胺基、二-(C 1-C 4)烷基胺基、胺基磺醯基、(C 1-C 4)烷基胺基磺醯基、二-(C 1-C 4)烷基胺基磺醯基、NHCO-(C 1-C 4)烷基、N(C 1-C 4)烷基-CO-(C 1-C 4)烷基、NHCO-(C 1-C 6)環烷基、N(C 1-C 4)烷基-CO-(C 1-C 6)環烷基、雜芳基、側氧基雜芳基、鹵雜芳基、鹵側氧基雜芳基、氰基雜芳基、氰基側氧基雜芳基、(C 1-C 4)鹵烷基雜芳基或(C 1-C 4)鹵烷基側氧基雜芳基。 A compound of formula (IA), wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have claim 1 or claim 2 or claim 3 or claim 4 or claim 5 or the definition of claim 6, and A 1 is nitrogen or =C(R 1 ), A 2 is nitrogen or =C(R 2 ), A 3 is nitrogen or =C(R 3 ), and A 4 is nitrogen or =C(R 4 ), A 5 is nitrogen or =C(R 5 ), wherein no more than two of the groups of A 1 , A 2 , A 3 , A 4 and A 5 are nitrogen, and R 1 , R 2 , R 3 , R 4 and R 5 are each independently hydrogen, cyano, halogen, nitro, ethyl hydrazine, hydroxy, amine, SF 5 -, (C 3 -C 6 ) cycloalkyl, (C 1 -C 4 )alkyl-(C 3 -C 6 )cycloalkyl, halo(C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl (C 1 -C 4 ) cyanoalkyl, (C 1 -C 4 )hydroxyalkyl, (C 1 -C 4 )alkoxy-(C 1 -C 4 )alkyl, (C 2 -C 4 ) alkenyl, (C 2 -C 4 )haloalkenyl, (C 2 -C 4 )cyanoalkenyl, (C 2 -C 4 )alkynyl, (C 2 -C 4 )halynynyl, C 2 -C 4 ) cyanoalkynyl, (C 1 -C 4 )alkoxy, (C 1 -C 4 )haloalkoxy, (C 1 -C 4 )cyanoalkoxy, (C 1 -C 4) alkoxy, - (C 1 -C 4) alkoxy, (C 1 -C 4) alkoxy imine , (C 1 -C 6) alkoxyimino group halo, (C 1 -C 4) alkylthio, (C 1 -C 4) haloalkyl group, (C 1 -C 4) alkyl Sulfur-(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylsulfinyl, (C 1 -C 4 )haloalkylsulfinyl, (C 1 -C 4 )alkyl Sulfonyl, (C 1 -C 4 ) haloalkylsulfonyl, (C 1 -C 4 )alkylsulfonyloxy, (C 1 -C 4 ) haloalkylsulfonyloxy, ( C 1 -C 4 )alkylcarbonyl, (C 1 -C 4 )haloalkylcarbonyl, aminocarbonyl, aminothiocarbonyl, (C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 ) haloalkylaminocarbonyl, bis-(C 1 -C 4 )alkylaminocarbonyl, (C 1 -C 4 )alkylsulfonylamino, (C 1 -C 4 )alkylamino , bis-(C 1 -C 4 )alkylamino, aminosulfonyl, (C 1 -C 4 )alkylaminosulfonyl, bis-(C 1 -C 4 )alkylaminosulfonate Sulfhydryl, NHCO-(C 1 -C 4 )alkyl, N(C 1 -C 4 )alkyl-CO-(C 1 -C 4 )alkyl, NHCO-(C 1 -C 6 )cycloalkyl , N(C 1 -C 4 )alkyl-CO-(C 1 -C 6 )cycloalkyl, heteroaryl, pendant heteroaryl, haloaryl, halooxy heteroaryl, cyanide heteroaryl group, a cyano group side heteroaryl, (C 1 -C 4) haloalkyl heteroaryl Or (C 1 -C 4) haloalkyl-oxo heteroaryl. 如請求項1至5中任一項之式(I-B)化合物， 其中Q、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5之定義。 A compound of formula (IB) according to any one of claims 1 to 5, Wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as claim 1 or claim 2 or request 3 or request 4 or claim 5. 如請求項1至5中任一項之式(I-C)化合物， 其中Q、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5之定義。 A compound of formula (IC) according to any one of claims 1 to 5, Wherein Q, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as claim 1 or claim 2 or request 3 or request 4 or claim 5. 如請求項1至5中任一項之式(I-D)化合物， 其中X、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5或請求項6之定義。 A compound of the formula (ID) according to any one of claims 1 to 5, Wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as claim 1 or claim 2 or claim 3 or request 4 or request 5 or claim 6. 如請求項1至5中任一項之式(I-E)化合物， 其中X、R 6、R 7、R 8、R 9、R 10及n具有如請求項1或請求項2或請求項3或請求項4或請求項5或請求項6之定義。 A compound of formula (IE) according to any one of claims 1 to 5, Wherein X, R 6 , R 7 , R 8 , R 9 , R 10 and n have the definitions as claim 1 or claim 2 or claim 3 or request 4 or request 5 or claim 6. 一種農化調配物，其包含如請求項1至6中任一項之式(I)化合物或如請求項7或8之式(I-A)化合物或如請求項9之式(I-B)化合物或如請求項10之式(I-C)化合物或如請求項11之式(I-D)化合物或如請求項12之式(I-E)化合物，及增效劑與/或界面活性劑。  An agrochemical formulation comprising a compound of formula (I) according to any one of claims 1 to 6 or a compound of formula (IA) according to claim 7 or 8 or a compound of formula (IB) according to claim 9 or as A compound of the formula (IC) of claim 10 or a compound of formula (ID) according to claim 11 or a compound of formula (IE) according to claim 12, and a synergist and/or a surfactant.   如請求項13之農化調配物，其另外包含其他農化活性成份。  An agrochemical formulation according to claim 13 which additionally comprises other agrochemical active ingredients.   一種控制動物害蟲之方法，其特徵在於讓如請求項1至6中任一項之式(I)化合物或如請求項7或8之式(I-A)化合物或如請求項9之式(I-B)化合物或如請求項10之式(I-C)化合物或如請求項11之式(I-D)化合物或如請求項12之式(I-E)化合物或如請求項13與14中一者之農化調配物作用在動物害蟲及/或其棲息地上。  A method of controlling an animal pest, characterized in that the compound of the formula (I) according to any one of claims 1 to 6 or the compound of the formula (IA) according to claim 7 or 8 or the formula (IB) of claim 9 Compound or a compound of formula (IC) according to claim 10 or a compound of formula (ID) according to claim 11 or a compound of formula (IE) according to claim 12 or an agrochemical formulation according to one of claims 13 and 14 In animal pests and / or their habitat.   一種以如請求項1至6中任一項之式(I)化合物或如請求項7或8之式(I-A)化合物或如請求項9之式(I-B)化合物或如請求項10之 式(I-C)化合物或如請求項11之式(I-D)化合物或如請求項12之式(I-E)化合物或如請求項13與14中一者之農化調配物於控制動物害蟲上之用途。  A compound of formula (I) according to any one of claims 1 to 6 or a compound of formula (IA) according to claim 7 or 8 or a compound of formula (IB) according to claim 9 or a formula of claim 10 ( The use of a compound or a compound of formula (ID) according to claim 11 or a compound of formula (IE) according to claim 12 or an agrochemical formulation according to one of claims 13 and 14 for controlling animal pests.   如請求項15之方法或如請求項16之用途，其中不包括人體或動物體之手術、治療及診斷處理。  The method of claim 15 or the use of claim 16, which does not include surgery, treatment, and diagnostic treatment of the human or animal body.  
TW106134315A 2016-10-07 2017-10-05 Heterocycle derivatives as pesticides TW201827411A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16192731 2016-10-07
??16192731.4 2016-10-07

Publications (1)

Publication Number Publication Date
TW201827411A true TW201827411A (en) 2018-08-01

Family

ID=57113157

Family Applications (1)

Application Number Title Priority Date Filing Date
TW106134315A TW201827411A (en) 2016-10-07 2017-10-05 Heterocycle derivatives as pesticides

Country Status (4)

Country Link
AR (1) AR109821A1 (en)
TW (1) TW201827411A (en)
UY (1) UY37434A (en)
WO (1) WO2018065288A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112661754B (en) * 2020-12-30 2023-06-16 成都开悦生命科技有限公司 Polycyclic compound for inhibiting RNA helicase DHX33
CN120882309A (en) 2023-03-14 2025-10-31 先正达农作物保护股份公司 Resistance to insecticides control of pests in (a) a plant

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2101114B (en) 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
ZA967800B (en) 1995-09-20 1997-04-03 Yamanouchi Pharma Co Ltd Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
AU2004257257B2 (en) 2003-07-10 2011-05-12 Osi Pharmaceuticals, Inc. Naphthylene derivatives as cytochrome P450 inhibitors
KR20060110344A (en) 2003-12-31 2006-10-24 쉐링-프라우 리미티드 How to control parasites in animals using imidazo [1,2-ｂ] pyridazine derivatives
WO2005095320A1 (en) 2004-04-02 2005-10-13 Ciba Specialty Chemicals Water Treatments Limited Preparation of acrylic acid derivatives from alpha or beta-hydroxy carboxylic acids
GB0414438D0 (en) 2004-06-28 2004-07-28 Syngenta Participations Ag Chemical compounds
JPWO2006004215A1 (en) 2004-07-07 2008-04-24 協友アグリ株式会社 Benzoxazole compounds
UA91341C2 (en) 2004-07-15 2010-07-26 Амр Текнолоджи, Інк. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
UY29016A1 (en) 2004-07-20 2006-02-24 Boehringer Ingelheim Int ANALOGS OF INHIBITING DIPEPTIDES OF HEPATITIS C
WO2006043635A1 (en) 2004-10-20 2006-04-27 Kumiai Chemical Industry Co., Ltd. 3-triazolylphenyl sulfide derivative and insecticide/acaricide/nematicide containing the same as active ingredient
CA2624558C (en) 2005-10-06 2011-02-22 Nippon Soda Co., Ltd. Cross-linked cyclic amine compounds and agents for pest control
EP2249820A1 (en) 2008-01-04 2010-11-17 Abbott Laboratories Trpa1 antagonists
TW200944520A (en) 2008-01-29 2009-11-01 Glaxo Group Ltd Spiro compounds as NPY Y5 receptor antagonists
JP5268461B2 (en) 2008-07-14 2013-08-21 Ｍｅｉｊｉ Ｓｅｉｋａファルマ株式会社 PF1364 substance, its production method, production strain, and agricultural and horticultural insecticide containing the same as an active ingredient
CN101337940B (en) 2008-08-12 2012-05-02 国家农药创制工程技术研究中心 Nitrogen heterocyclic ring dichloro allyl ether compound with insecticidal activity
CN101337937B (en) 2008-08-12 2010-12-22 国家农药创制工程技术研究中心 N-benz-3-substituted amino pyrazoles compounds with insecticidal activity
CN101715774A (en) 2008-10-09 2010-06-02 浙江化工科技集团有限公司 Preparation and use of compound having insecticidal activity
EP2184273A1 (en) 2008-11-05 2010-05-12 Bayer CropScience AG Halogen substituted compounds as pesticides
GB0820344D0 (en) 2008-11-06 2008-12-17 Syngenta Ltd Herbicidal compositions
US8273764B2 (en) 2009-04-28 2012-09-25 Sumitomo Chemical Company, Limited Fused heterocyclic compounds and use thereof
TWI450894B (en) 2009-12-18 2014-09-01 Mitsubishi Tanabe Pharma Corp Novel antiplatelet drugs
WO2011085575A1 (en) 2010-01-15 2011-07-21 江苏省农药研究所股份有限公司 Ortho-heterocyclyl formanilide compounds, their synthesis methods and use
WO2011126688A1 (en) 2010-04-07 2011-10-13 Iowa State University Research Foundation, Inc. Method for producing olefins
PL2631235T3 (en) 2010-08-31 2016-05-31 Meiji Seika Pharma Co Ltd Pest control agent
CN101967139B (en) 2010-09-14 2013-06-05 中化蓝天集团有限公司 Fluoro methoxylpyrazole-containing o-formylaminobenzamide compound, synthesis method and application thereof
TW201242962A (en) 2010-12-01 2012-11-01 Sumitomo Chemical Co Pyrimidine compound and use for pest control thereof
TWI617559B (en) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 2-arylimidazo[1,2-b]pyridazine, 2-phenylimidazo[1,2-a]pyridine, and 2-phenylimidazo[1,2-a]pyrazine derivatives
BR112013016022B1 (en) 2010-12-24 2019-05-07 Sumitomo Chemical Company, Limited Fused heterocyclic compound and use for same control.
UA106692C2 (en) 2011-02-23 2014-09-25 Пфайзер Інк. Imidazo [5,1-f] [1,2,4] triazin to treat neurological disorders
GB201109763D0 (en) 2011-06-10 2011-07-27 Ucl Business Plc Compounds
US8975276B2 (en) 2011-06-29 2015-03-10 Bristol-Myers Squibb Company Inhibitors of PDE10
TWI545119B (en) 2011-08-04 2016-08-11 住友化學股份有限公司 Fused heterocyclic compounds and their use in pest control
WO2013050317A1 (en) 2011-10-03 2013-04-11 Syngenta Limited Polymorphs of an isoxazoline derivative
CN102391261A (en) 2011-10-14 2012-03-28 上海交通大学 N-substituted dioxazine compound as well as preparation method and application thereof
WO2013144213A1 (en) 2012-03-30 2013-10-03 Basf Se N-substituted pyridinylidene compounds and derivatives for combating animal pests
EP2647626A1 (en) 2012-04-03 2013-10-09 Syngenta Participations AG. 1-Aza-spiro[4.5]dec-3-ene and 1,8-diaza-spiro[4.5]dec-3-ene derivatives as pesticides
BR112014026746A2 (en) 2012-04-27 2017-06-27 Dow Agrosciences Llc pesticide compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US20130296602A1 (en) 2012-05-07 2013-11-07 Jane Ellen Godlewski Conversion of Methyl-2-Acetoxy Propionate to Methyl Acrylate and Acrylic Acid
WO2013191113A1 (en) 2012-06-18 2013-12-27 住友化学株式会社 Fused heterocyclic compound
CN103109816B (en) 2013-01-25 2014-09-10 青岛科技大学 Thiobenzamide compounds and application thereof
CN103232431B (en) 2013-01-25 2014-11-05 青岛科技大学 Dihalogenated pyrazole amide compound and its use
WO2014158644A1 (en) 2013-03-13 2014-10-02 Dow Agrosciences Llc Process for the preparation of triaryl rhamnose carbamates
UY35421A (en) 2013-03-15 2014-10-31 Nihon Nohyaku Co Ltd CONDENSED HETEROCYCLIC COMPOUND OR ITS SALT, AGRICULTURAL OR HERITAGE INSECTICIDE THAT INCLUDES THE COMPOSITE AND METHOD OF USE OF THE INSECTICIDE
WO2014148451A1 (en) 2013-03-19 2014-09-25 日本農薬株式会社 Fused heterocyclic compound or salt thereof, pesticide for agricultural and horticultural use containing said compound, and usage method therefor
WO2014187762A1 (en) 2013-05-23 2014-11-27 F. Hoffmann-La Roche Ag 2-phenylimidazo[1,2-a]pyrimidines as imaging agents
WO2015002211A1 (en) 2013-07-01 2015-01-08 住友化学株式会社 Fused heterocyclic compound and pest control use thereof
JP6677637B2 (en) 2013-07-02 2020-04-08 シンジェンタ パーティシペーションズ アーゲー Bicyclic or tricyclic heterocycles with sulfur-containing substituents that are pesticidally active
CN103524422B (en) 2013-10-11 2015-05-27 中国农业科学院植物保护研究所 Benzimidazole derivative, and preparation method and purpose thereof
US9102654B2 (en) 2013-10-17 2015-08-11 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
CA2925873A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
EP2873668A1 (en) 2013-11-13 2015-05-20 Syngenta Participations AG. Pesticidally active bicyclic heterocycles with sulphur containing substituents
ES2728316T3 (en) 2013-12-20 2019-10-23 Syngenta Participations Ag Active substituted 5,5-bicyclic heterocycles as pesticides with sulfur-containing substituents
US10364243B2 (en) 2014-02-17 2019-07-30 Bayer Cropscience Aktiengesellschaft 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides
AR099677A1 (en) 2014-03-07 2016-08-10 Sumitomo Chemical Co FUSION HETEROCYCLIC COMPOUND AND ITS USE FOR PEST CONTROL
WO2015198859A1 (en) 2014-06-26 2015-12-30 住友化学株式会社 Condensed heterocyclic compound
KR102292928B1 (en) 2014-06-26 2021-08-25 수미토모 케미칼 컴퍼니 리미티드 Method for producing fused heterocyclic compound
RU2017103953A (en) 2014-07-08 2018-08-08 Зингента Партисипейшнс Аг PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SURFACE-CONTAINING SUBSTITUTES
ES2701835T3 (en) 2014-08-07 2019-02-26 Syngenta Participations Ag Heterocyclic derivatives with pesticidal activity with sulfur-containing substituents
US10005775B2 (en) 2014-08-12 2018-06-26 Syngenta Participations, Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
ES2701859T3 (en) 2014-08-21 2019-02-26 Syngenta Participations Ag Active heterocyclic derivatives as a pesticide with sulfur-containing substituents
WO2016039444A1 (en) 2014-09-12 2016-03-17 日本農薬株式会社 Imidazopyridazine compound or salts thereof, agricultural and horticultural insecticide containing said compound, and use of same
TW201625522A (en) 2014-09-12 2016-07-16 Nihon Nohyaku Co Ltd Imidazopyridazine compound or salts thereof and agricultural and horticultural insecticide containing said compound and method of using same
EP3194394B1 (en) 2014-09-16 2019-01-09 Syngenta Participations AG Pesticidally active tetracyclic derivatives with sulphur containing substituents
WO2016046071A1 (en) 2014-09-25 2016-03-31 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
WO2016058928A1 (en) 2014-10-14 2016-04-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
US10544148B2 (en) 2014-10-16 2020-01-28 Syngenta Participations Ag Pesticidally active tetracyclic heterocyclic derivatives with sulphur containing substituents
BR112017009454B1 (en) 2014-11-07 2022-05-03 Syngenta Participations Ag Compost, pesticidal composition, method for controlling pests and method for protecting plant propagation material from attack by pests
JP6695879B2 (en) 2014-12-11 2020-05-20 シンジェンタ パーティシペーションズ アーゲー Pesticidally Active Tetracyclic Derivatives Bearing Sulfur-Containing Substituents
BR112017012638B1 (en) 2014-12-17 2021-07-27 Syngenta Participations Ag DERIVATIVES OF ACTIVE HETEROCYCLICS FROM THE PESTICIDE POINT OF VIEW WITH SULFUR-CONTAINING SUBSTITUENTS
ES2703172T3 (en) 2014-12-29 2019-03-07 Syngenta Participations Ag Tetracyclic derivatives active as pesticides with sulfur-containing substituents
BR112017014064A2 (en) 2014-12-31 2018-07-17 Syngenta Crop Protection A.G. active polycyclic derivatives with pesticide-active sulfur-containing substituents
WO2016113155A1 (en) 2015-01-13 2016-07-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
ES2924890T3 (en) 2015-01-19 2022-10-11 Syngenta Participations Ag Pesticide-active polycyclic derivatives with sulfur-containing substituents
TWI696612B (en) 2015-01-29 2020-06-21 日商日本農藥股份有限公司 Condensed heterocyclic compound having a cycloalkylpyridyl group or a salt thereof, agricultural and horticultural insecticide containing the compound, and method of using the same
WO2016125622A1 (en) 2015-02-03 2016-08-11 住友化学株式会社 Benzoxazole compound, and use thereof for noxious arthropod control
WO2016125621A1 (en) 2015-02-03 2016-08-11 住友化学株式会社 Benzimidazole compound, and use thereof for noxious arthropod control
UY36547A (en) 2015-02-05 2016-06-01 Bayer Cropscience Ag BICYCLIC CONDENSED HETEROCYCLIC DERIVATIVES REPLACED BY 2- (HET) ARILO AS PESTICIDES
UY36548A (en) 2015-02-05 2016-06-01 Bayer Cropscience Ag BICYCLIC CONDENSED HETEROCYCLIC DERIVATIVES REPLACED BY 2- (HET) ARILO AS PESTICIDES
SG11201706489YA (en) 2015-02-12 2017-09-28 Nissan Chemical Ind Ltd Condensed heterocyclic compounds and pesticides

Also Published As

Publication number Publication date
AR109821A1 (en) 2019-01-23
WO2018065288A1 (en) 2018-04-12
UY37434A (en) 2018-05-31

Similar Documents

Publication Publication Date Title
US10550116B2 (en) Fused bicyclic heterocycle derivatives as pesticides
AU2017328614B2 (en) Pyrazolo [1,5-a]pyridine derivatives and their use as pesticides
US10765116B2 (en) 2-[3-(alkylsulfonyl)-2H-indazol-2-yl]-3H-imidazo[4,5-B]pyridine derivatives and similar compounds as pesticides
US11058115B2 (en) Heterocycle derivatives as pesticides
US10561145B2 (en) Fused bicyclic heterocycle derivatives as pesticides
TW201945363A (en) Fused bicyclic heterocycle derivatives as pesticides
US20200236940A1 (en) 2-(het)aryl-substituted fused heterocycle derivatives as pesticides
TW201738248A (en) Fused bicyclic heterocycle derivatives as pesticides
CN109996799A (en) Fused bicyclic heterocycle derivative as pest control agent
TW201838990A (en) Fused bicyclic heterocycle derivatives as pesticides
TW201741310A (en) Fused bicyclic heterocycle derivatives as pesticides
TW201837026A (en) Heterocycle derivatives as pesticides
TW201734002A (en) Substituted malonamides as insecticides
CN111886238A (en) Fused bicyclic heterocyclic derivatives as pest control agents
TW201808942A (en) Substituted 2-heterocyclylimidazolylcarboxamides as pesticides
TW201741299A (en) Substituted imidazolylcarboxamides as pesticides
US11089783B2 (en) 2-(het)aryl-substituted fused heterocycle derivatives as pesticides
TW201741301A (en) Substituted imidazolylcarboxamides as pesticides
US11505553B2 (en) 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides
US11339155B2 (en) 2-(het)aryl-substituted fused bicyclic heterocycle derivatives as pesticides
TW201827411A (en) Heterocycle derivatives as pesticides