TW201818914A - Hair treating agent, and promoter for penetration into hair - Google Patents
Hair treating agent, and promoter for penetration into hair Download PDFInfo
- Publication number
- TW201818914A TW201818914A TW106136504A TW106136504A TW201818914A TW 201818914 A TW201818914 A TW 201818914A TW 106136504 A TW106136504 A TW 106136504A TW 106136504 A TW106136504 A TW 106136504A TW 201818914 A TW201818914 A TW 201818914A
- Authority
- TW
- Taiwan
- Prior art keywords
- hair
- agent
- treatment agent
- hair treatment
- carboxylic acid
- Prior art date
Links
- 210000004209 hair Anatomy 0.000 title claims abstract description 142
- 230000035515 penetration Effects 0.000 title abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 108
- 238000011282 treatment Methods 0.000 claims abstract description 70
- -1 alkyl ether carboxylic acid amino acid salt Chemical class 0.000 claims abstract description 26
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 22
- 238000000034 method Methods 0.000 claims abstract description 15
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract description 7
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 7
- 229930195734 saturated hydrocarbon Natural products 0.000 claims abstract description 7
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims abstract description 7
- 150000003839 salts Chemical class 0.000 claims description 21
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims description 14
- 239000004475 Arginine Substances 0.000 claims description 11
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 11
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 11
- 239000003961 penetration enhancing agent Substances 0.000 claims description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 9
- 239000004472 Lysine Substances 0.000 claims description 9
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims description 9
- 229960003151 mercaptamine Drugs 0.000 claims description 9
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 229960001340 histamine Drugs 0.000 claims description 7
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
- 235000018417 cysteine Nutrition 0.000 claims description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 3
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 3
- 229940035024 thioglycerol Drugs 0.000 claims description 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical group OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Chemical group OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 abstract 1
- 238000013461 design Methods 0.000 description 27
- 230000000694 effects Effects 0.000 description 12
- 230000007794 irritation Effects 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 10
- 230000007935 neutral effect Effects 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 8
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 150000005215 alkyl ethers Chemical class 0.000 description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 6
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000007800 oxidant agent Substances 0.000 description 5
- 210000004761 scalp Anatomy 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 150000003863 ammonium salts Chemical class 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- SUWCVSZZLFOSJL-UHFFFAOYSA-N 3-sulfanyloxolan-2-one Chemical compound SC1CCOC1=O SUWCVSZZLFOSJL-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960003067 cystine Drugs 0.000 description 3
- 229910052742 iron Inorganic materials 0.000 description 3
- PMNLUUOXGOOLSP-UHFFFAOYSA-N 2-mercaptopropanoic acid Chemical compound CC(S)C(O)=O PMNLUUOXGOOLSP-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000002981 blocking agent Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 230000003648 hair appearance Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- JKYQJWASCFMEMZ-BYPYZUCNSA-N (2r)-2-(2-acetylhydrazinyl)-3-sulfanylpropanoic acid Chemical compound CC(=O)NN[C@@H](CS)C(O)=O JKYQJWASCFMEMZ-BYPYZUCNSA-N 0.000 description 1
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- 229940058020 2-amino-2-methyl-1-propanol Drugs 0.000 description 1
- OGMADIBCHLQMIP-UHFFFAOYSA-N 2-aminoethanethiol;hydron;chloride Chemical compound Cl.NCCS OGMADIBCHLQMIP-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- CBTVGIZVANVGBH-UHFFFAOYSA-N aminomethyl propanol Chemical compound CC(C)(N)CO CBTVGIZVANVGBH-UHFFFAOYSA-N 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229940097265 cysteamine hydrochloride Drugs 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 229940102253 isopropanolamine Drugs 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229940063675 spermine Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/04—Preparations for permanent waving or straightening the hair
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Description
本發明有關於毛髮處理劑及使用了該毛髮處理劑之燙髮或捲縮毛髮矯直處理方法。又，本發明有關於毛髮滲透促進劑。The present invention relates to a hair treatment agent and a method for straightening or curling hair using the hair treatment agent. The present invention also relates to a hair penetration enhancer.
發明背景 針對在毛髮形成波浪(wave)、捲曲(curl)及拉直(straight)等毛髮的一般變形方法，可舉如下方法：在毛髮經人工變形的狀態下，使用摻合了還原劑之藥劑，將毛髮內部的胱胺酸(SS)鍵結切斷，之後，使用摻合了氧化劑之藥劑使胱胺酸(SS)鍵結再次鍵結，固定已變形的毛髮。該等還原劑是使用鹼性藥劑作為用以切斷毛髮內部的胱胺酸(SS)鍵結之滲透促進劑。BACKGROUND OF THE INVENTION Aiming at the general methods of deforming hair such as waves, curls, and straights in hair, the following methods can be used: in the state where the hair is artificially deformed, a reducing agent-containing agent is used. The cystine (SS) bond inside the hair is cut off, and then the cystine (SS) bond is re-bonded with an agent mixed with an oxidizing agent to fix the deformed hair. These reducing agents use alkaline agents as permeation enhancers to cut cystine (SS) bonds inside the hair.
一般所使用之還原劑可舉氫硫乙酸(或其鹽)、半胱胺酸(或其鹽)、半胱胺(或其鹽)、亞硫酸鹽、丁內酯硫醇、氫硫乙酸甘油酯、硫甘油等。Commonly used reducing agents include hydrothioacetic acid (or its salt), cysteine (or its salt), cysteamine (or its salt), sulfite, butyrolactone thiol, and hydrothioacetic acid glycerol Esters, thioglycerols, etc.
又，為了透過毛髮形成更穩固的波浪設計、捲曲設計或拉直設計，已知利用鹼性藥劑提高pH是有效的。鹼性藥劑可舉氨、胺類、中性鹽、精胺酸等鹼性胺基酸等。鹼性藥劑會軟化、膨潤毛髮，促進還原劑的作用，然亦會有所謂因揮發性而有刺激臭味、對毛髮之殘留性高、會損傷頭皮及頭髮之蛋白質而有刺激性等問題點。因此，雖然亦有使用酸性的燙髮溶劑，然會有波浪效率低、損傷防止效果亦弱等問題點。Moreover, in order to form a more stable wave design, a curl design, or a straight design through the hair, it is known that it is effective to raise the pH using an alkaline agent. Examples of the basic agent include basic amino acids such as ammonia, amines, neutral salts, and arginine. Alkaline medicines can soften and swell the hair and promote the role of reducing agent. However, there are also problems such as irritation and odor due to volatility, high residue on hair, and irritation that can damage scalp and hair proteins . Therefore, although an acidic permanent wave solvent is also used, there are problems such as low wave efficiency and weak damage prevention effect.
在燙髮處理當中，為了使對於毛髮之波浪效率提升，需要使還原劑對毛髮之作用有效率的發揮，因此自以往在摻合還原劑或鹼性藥劑時，有嘗試併用滲透促進劑提升對毛髮之滲透。In the perm treatment, in order to improve the wave efficiency of the hair, it is necessary to effectively reduce the effect of the reducing agent on the hair. Therefore, in the past, when mixing the reducing agent or the alkaline agent, there have been attempts to improve the hair with a penetration enhancer. Of penetration.
專利文獻1及非專利文獻1指出，透過使用陰離子性界面活性劑之具有特定結構的烷基醚羧酸胺基酸鹽，可獲得低刺激性且使用性及穩定性優異的液體洗淨組成物。Patent Document 1 and Non-Patent Document 1 point out that by using an alkyl ether carboxylic acid amino acid salt having a specific structure with an anionic surfactant, a liquid cleaning composition having low irritation and excellent usability and stability can be obtained .
習知技術文獻 專利文獻 專利文獻1：日本特許第5057337號公報Known technical documents Patent documents Patent document 1: Japanese Patent No. 5057337
非專利文獻 非專利文獻1：Journal of Surfactants and Detergents, March 2016, Volume 19, Issue 2, pp 421-424Non-Patent Literature Non-Patent Literature 1: Journal of Surfactants and Detergents, March 2016, Volume 19, Issue 2, pp 421-424
發明概要 發明欲解決之課題 如前述，已知利用了還原劑之燙髮劑是透過鹼性藥劑將pH做成弱~強鹼性，藉此可在毛髮良好的形成波浪設計、形成捲曲設計或形成拉直設計，然因利用鹼性藥劑提升滲透性，在施術中會產生起因於鹼性的刺激，而會損傷頭皮及頭髮的蛋白質。Summary of the Invention As described above, the problem to be solved by the invention is as follows. It is known that a permanent wave agent using a reducing agent makes the pH weak to strong alkaline through an alkaline agent, thereby making it possible to form a wavy design, a curly design, or a good hair. Straightening design, but because of the use of alkaline agents to improve permeability, during the operation will produce alkaline due to stimulation, which will damage the scalp and hair protein.
又，用於燙髮劑之滲透促進劑在效果上目前仍不足夠，且亦有會表現出刺激性的缺點，因此無法充分提升對毛髮的浴比，而有無法使對於毛髮之波浪效率及波浪保持率充分提升這樣的問題。In addition, the penetration enhancer used for perming agent is still insufficient in effect, and also has the disadvantage of showing irritation. Therefore, the bath ratio to hair cannot be fully improved, and the wave efficiency and wave to hair cannot be improved. The retention rate raises such a problem sufficiently.
本發明之目的在提供一種毛髮處理劑、及使用了該毛髮處理劑之燙髮或捲縮毛髮矯直處理方法，該毛髮處理劑不須使用鹼性藥劑，即便在中性區域仍可達到優異的毛髮設計形成作用，並且為低刺激性。又，本發明之目的在提供一種低刺激且對毛髮之滲透促進作用亦優異之毛髮滲透促進劑。The object of the present invention is to provide a hair treatment agent and a method for straightening or curling hair straightening treatment using the hair treatment agent. The hair treatment agent does not need to use an alkaline agent, and can achieve excellent performance even in neutral areas. Hair design is effective and low-irritant. Another object of the present invention is to provide a hair permeation enhancer which has low irritation and excellent permeation promotion effect on hair.
用以解決課題之手段 本案發明人等為達成上述目的而一再精心研究，結果獲得如下發現：透過在摻合了還原劑之燙髮劑中摻合特定量之烷基醚羧酸胺基酸鹽，可使波浪效率提升，結果便是可降低鹼性藥劑之摻合量，還會減少頭皮及頭髮之蛋白質的損傷而成為低刺激性。Means for Solving the Problem The inventors of the present case have repeatedly studied carefully in order to achieve the above-mentioned object, and as a result, they have found that by blending a specific amount of an alkyl ether carboxylic acid amino acid salt with a reducing agent-doped perm agent, The wave efficiency can be improved. As a result, the amount of the alkaline agent can be reduced, and the protein damage of the scalp and hair can be reduced to become less irritating.
本發明是基於該等發現並進一步一再探討所完成，而提供如下之毛髮處理劑、燙髮或捲縮毛髮矯直處理方法及毛髮滲透促進劑。The present invention is based on these findings and further discussions have been completed, and provides the following hair treatment agents, perming or curling hair straightening treatment methods, and hair penetration enhancers.
項1.一種燙髮用或捲縮毛髮矯直用之毛髮處理劑，含有通式(I)所表示之烷基醚羧酸胺基酸鹽及還原劑： R1 -O-(CH2 CH2 O)n CH2 COOM (I) (式中，R1 表示飽和或不飽和烴基、n表示1~10之數、M表示離胺酸、組胺酸或精胺酸)。 項2.如項1之毛髮處理劑，其中前述還原劑是選自於由半胱胺及其鹽、半胱胺酸及其鹽、氫硫乙酸及其鹽、亞硫酸鹽、亞硫酸氫鹽、丁內酯硫醇、氫硫乙酸甘油酯以及硫甘油所構成群組中之至少1種。 項3.如項1毛髮處理劑，其中前述還原劑為半胱胺或其鹽。 項4.如項1至3中任一項之毛髮處理劑，其為燙髮用第1劑。 項5.如項1至4中任一項之毛髮處理劑，其pH為6.0～9.6。 項6.一種燙髮或捲縮毛髮矯直處理方法，包含將如項1至5中任一項之毛髮處理劑應用到全部或一部分頭髮之步驟。 項7.一種毛髮滲透促進劑，含有通示(I)所表示之烷基醚羧酸胺基酸鹽： R1 -O-(CH2 CH2 O)n CH2 COOM (I) (式中，R1 表示飽和或不飽和烴基、n表示1～10之數、M表示離胺酸、組胺酸或精胺酸)。Item 1. A hair treatment agent for perming or curling hair straightening, comprising an alkyl ether carboxylic acid amino salt represented by the general formula (I) and a reducing agent: R 1 -O- (CH 2 CH 2 O) n CH 2 COOM (I) (wherein R 1 represents a saturated or unsaturated hydrocarbon group, n represents a number from 1 to 10, and M represents a lysine, histamine, or arginine). Item 2. The hair treatment agent according to item 1, wherein the reducing agent is selected from the group consisting of cysteamine and its salts, cysteine and its salts, hydrothioacetic acid and its salts, sulfite and bisulfite , Butyrolactone thiol, glyceryl hydrothioacetate, and thioglycerol. Item 3. The hair treating agent according to item 1, wherein the reducing agent is cysteamine or a salt thereof. Item 4. The hair treatment agent according to any one of Items 1 to 3, which is the first agent for perming. Item 5. The hair treatment agent according to any one of Items 1 to 4, which has a pH of 6.0 to 9.6. Item 6. A method for straightening or curling hair straightening treatment, comprising the step of applying the hair treating agent according to any one of Items 1 to 5 to all or part of the hair. Item 7. A hair penetration enhancer comprising the alkyl ether carboxylic acid amino salt represented by general formula (I): R 1 -O- (CH 2 CH 2 O) n CH 2 COOM (I) (wherein R 1 represents a saturated or unsaturated hydrocarbon group, n represents a number from 1 to 10, and M represents a lysine, histamine, or arginine).
發明效果 本發明之毛髮處理劑即便在少量摻合或不使用鹼性藥劑且pH在中性區域之情況下，仍可達到與在弱~強鹼性情況下同等以上之形成波浪設計、捲曲設計、拉直設計等的設計形成效果。進一步，本發明之毛髮處理劑含有已知是低刺激性的烷基醚羧酸胺基酸鹽，因此會減少蛋白質的損傷而為低刺激性。ADVANTAGE OF THE INVENTION Even if the hair treatment agent of the present invention is mixed with a small amount or without using an alkaline agent and the pH is in a neutral region, it can still achieve a wave design and a curl design equal to or more than that in a weak to strong alkaline condition. , Straightening design and other design effects. Furthermore, the hair treatment agent of the present invention contains an alkyl ether carboxylic acid aminoammonium salt which is known to have low irritation, and thus reduces protein damage and has low irritation.
又，本發明之毛髮滲透促進劑除了低刺激之外，對毛髮之滲透促進作用亦優異。In addition, the hair permeation enhancer of the present invention is excellent in permeation promoting effect on hair in addition to low irritation.
以下，將針對本發明進行詳細說明。Hereinafter, the present invention will be described in detail.
此外，本說明書中所謂「含有(comprise)」，亦包含「實質上由...組成(essentially consist of)」的意思、「由...所組成(consist of)」的意思。In addition, the term "comprise" in this specification also includes the meaning of "essentially consist of" and the meaning of "consist of".
本說明書中的胺基酸意指L體、D體或DL體，且宜為L體。The amino acid in this specification means an L-form, a D-form, or a DL-form, and is preferably an L-form.
本發明之燙髮用或捲縮毛髮矯直用之毛髮處理劑，特徵在於含有通式(I)所表示之烷基醚羧酸胺基酸鹽及還原劑： R1 -O-(CH2 CH2 O)n CH2 COOM (I) (式中，R1 表示飽和或不飽和烴基、n表示1~10之數、M表示離胺酸、組胺酸或精胺酸)。The hair treatment agent for perming or curling hair straightening according to the present invention is characterized by containing an alkyl ether carboxylic acid amino salt represented by the general formula (I) and a reducing agent: R 1 -O- (CH 2 CH 2 O) n CH 2 COOM (I) (wherein R 1 represents a saturated or unsaturated hydrocarbon group, n represents a number from 1 to 10, and M represents a lysine, histamine, or arginine).
通式(I)所表示之烷基醚羧酸胺基酸鹽是所謂的陰離子性界面活性劑，且如專利文獻1所記載，蛋白質之損傷少而為低刺激性。The alkyl ether carboxylic acid amino salt represented by the general formula (I) is a so-called anionic surfactant, and as described in Patent Document 1, the protein is less damaging and less irritating.
R1 所表示之飽和或不飽和烴基可例示碳數8~18之芳香族烴及直鏈狀或支鏈狀脂肪烴，其中，宜為脂肪族烴(特別是烷基、烯基)。這樣的脂肪族烴基可舉例如辛基、癸基、十二烷基、十三烷基、十四烷基、十六烷基、十八烷基、二十二烷基、2-乙基己基、2-己基癸基、2-辛基十一烷基等作為適宜例子，其中以十二烷基、十三烷基、十四烷基為佳。Examples of the saturated or unsaturated hydrocarbon group represented by R 1 include aromatic hydrocarbons having 8 to 18 carbon atoms and linear or branched aliphatic hydrocarbons. Among them, aliphatic hydrocarbons (particularly alkyl and alkenyl) are preferred. Examples of such an aliphatic hydrocarbon group include octyl, decyl, dodecyl, tridecyl, tetradecyl, hexadecyl, octadecyl, behenyl, 2-ethylhexyl As suitable examples, 2-hexyldecyl, 2-octylundecyl, and the like, among them, dodecyl, tridecyl, and tetradecyl are preferred.
聚氧乙烯之聚合度n為平均聚合度，一般而言是1~5，且宜為2~4，以3為佳。The degree of polymerization n of polyoxyethylene is the average degree of polymerization, generally 1 to 5, and preferably 2 to 4, and preferably 3.
M為離胺酸、組胺酸或精胺酸。透過作成該鹼性胺基酸的鹽，可降低對細胞的刺激。M is lysine, histidine or arginine. By making a salt of this basic amino acid, the stimulation of cells can be reduced.
通式(I)所表示之烷基醚羧酸胺基酸鹽若為上述者，則可單獨使用，或2種以上混合使用。The alkyl ether carboxylic acid amino salt represented by the general formula (I) may be used alone or in combination of two or more kinds as long as it is the above.
本發明毛髮處理劑中通式(I)所表示之烷基醚羧酸胺基酸鹽的摻合量可視毛髮處理劑之種類等而適宜設定，可舉例如0.01~5質量%，且宜為0.1~2質量%。The blending amount of the alkyl ether carboxylic acid amino salt represented by the general formula (I) in the hair treatment agent of the present invention may be appropriately set depending on the type of the hair treatment agent, and may be, for example, 0.01 to 5% by mass, and is preferably 0.1 ~ 2 mass%.
通式(I)所表示之烷基醚羧酸胺基酸鹽對本發明毛髮處理劑之摻合，可藉由分別單獨添加烷基醚羧酸與胺基酸的形式來摻合。The blending of the alkyl ether carboxylic acid amino salt represented by the general formula (I) to the hair treatment agent of the present invention can be performed by separately adding the alkyl ether carboxylic acid and the amino acid separately.
可認為通式(I)所表示之烷基醚羧酸胺基酸鹽可在毛髮處理劑中促進還原劑對毛髮的滲透(換言之，可認為具有作為毛髮滲透促進劑的作用)。It is considered that the alkyl ether carboxylic acid amino salt represented by the general formula (I) can promote the penetration of the reducing agent into the hair in the hair treatment agent (in other words, it can be considered to have a function as a hair penetration enhancer).
在本發明使用之還原劑可舉例如半胱胺或其鹽(例如鹽酸鹽)、半胱胺酸或其鹽(例如鹽酸鹽)、N-乙醯基半胱胺酸或其鹽、麩胱甘肽或其鹽、氫硫乙酸或其鹽(例如銨鹽、單乙醇胺鹽)、亞硫酸鹽(例如鈉鹽)、亞硫酸氫鹽(例如鈉鹽)、丁內酯硫醇、氫硫乙酸甘油酯、硫甘油、硫代乳酸或其鹽(例如銨鹽、單乙醇胺鹽)等。Examples of the reducing agent used in the present invention include cysteamine or a salt thereof (e.g., hydrochloride), cysteine acid or a salt thereof (e.g., hydrochloride salt), N-acetamidocysteine acid or a salt thereof, Glutathione or its salt, hydrothioacetic acid or its salt (e.g. ammonium salt, monoethanolamine salt), sulfite (e.g. sodium salt), bisulfite (e.g. sodium salt), butyrolactone thiol, hydrogen Glyceryl thioacetate, thioglycerol, thiolactic acid or a salt thereof (for example, ammonium salt, monoethanolamine salt) and the like.
還原劑宜為半胱胺或其鹽，且以半胱胺鹽酸鹽為佳。The reducing agent is preferably cysteamine or a salt thereof, and more preferably cysteamine hydrochloride.
還原劑可單獨使用，或2種以上混合使用。The reducing agents can be used alone or in combination of two or more.
本發明毛髮處理劑中之還原劑的摻合量可因應毛髮處理劑之種類等來適宜設定，可舉例如0.5~11質量%，且宜為4.0~6.0質量%。The blending amount of the reducing agent in the hair treatment agent of the present invention can be appropriately set according to the type of the hair treatment agent, and can be, for example, 0.5 to 11% by mass, and preferably 4.0 to 6.0% by mass.
本發明毛髮處理劑中可視需要摻合鹼性藥劑。可摻合在本發明毛髮處理劑中之鹼性藥劑可舉例如氨、烷醇胺(例如單乙醇胺、異丙醇胺、2-胺基-2-甲基-1-丙醇)、鹼性胺基酸(例如精胺酸)、嗎啉、碳酸鹽(例如碳酸銨、碳酸鈉、碳酸氫鈉)、氫氧化鉀、氫氧化鈉等。在本發明之毛髮處理劑摻合鹼性藥劑時之摻合量可因應毛髮處理劑之種類等來適宜設定。本發明之毛髮處理劑中可以較通常還少且在無刺激性的範圍內摻合鹼性藥劑。The hair treatment agent of the present invention may be blended with an alkaline agent as required. Examples of the alkaline agent that can be incorporated in the hair treatment agent of the present invention include ammonia, alkanolamines (e.g., monoethanolamine, isopropanolamine, 2-amino-2-methyl-1-propanol), and alkaline Amino acids (eg, arginine), morpholine, carbonates (eg, ammonium carbonate, sodium carbonate, sodium bicarbonate), potassium hydroxide, sodium hydroxide, and the like. The blending amount when the alkaline treatment is mixed with the hair treatment agent of the present invention can be appropriately set according to the type of the hair treatment agent and the like. The hair treatment agent of the present invention may contain less than usual, and an alkaline agent may be blended in a non-irritating range.
本發明之毛髮處理劑中除了上述成分之外，還可摻合在燙髮劑、捲曲劑、捲縮毛髮矯直劑等之中所摻合的周知成分，如此成分可舉例如水、陰離子性界面活性劑、陽離子性界面活性劑、非離子性界面活性劑、兩性界面活性劑、矽酮類、蠟類、高級醇、多元醇、脂肪酸、油性成分、油脂類、烴、植物萃取物、維生素類、蛋白質或其水解物、天然或合成高分子、胺基酸、金屬封鎖劑、濕潤劑、紫外線吸收劑、抗氧化劑、pH調整劑、著色劑、抗發炎劑、防腐劑、香料、溶劑、噴射劑等。In addition to the above components, the hair treatment agent of the present invention may be blended with well-known components blended with a permanent wave agent, a curling agent, a curled hair straightener, and the like. Examples of such components include water and anionic interfacial activity. Agents, cationic surfactants, nonionic surfactants, amphoteric surfactants, silicones, waxes, higher alcohols, polyols, fatty acids, oily ingredients, oils, hydrocarbons, plant extracts, vitamins, Proteins or their hydrolysates, natural or synthetic polymers, amino acids, metal blocking agents, humectants, UV absorbers, antioxidants, pH adjusters, colorants, anti-inflammatory agents, preservatives, fragrances, solvents, sprays Wait.
本發明毛髮處理劑之pH並無特別限定，通常為pH6.0~10.0，且宜為pH6.0~9.6、以pH6.0~8.0為佳、以pH6.5~7.5更佳，或者亦可做成酸性區域或中性區域。藉由做成如此中性區域之pH，可降低刺激性。此外，本說明書中所謂「中性區域」意指pH6.0~8.0之範圍。The pH of the hair treatment agent of the present invention is not particularly limited, and is usually pH 6.0 to 10.0, and preferably pH 6.0 to 9.6, preferably pH 6.0 to 8.0, more preferably pH 6.5 to 7.5, or may be Make it acidic or neutral. By making the pH in such a neutral region, irritation can be reduced. The "neutral region" in this specification means a range of pH 6.0 to 8.0.
本發明之毛髮處理劑是可用於燙髮或捲縮毛髮矯直之物，亦即，亦可稱為燙髮劑、捲曲劑、捲縮毛髮矯直劑等，而在做成2劑式來使用時，亦可稱為燙髮用第1劑、捲縮毛髮矯直用第1劑等。The hair treatment agent of the present invention is a substance that can be used for perming or curling hair straightening, that is, it can also be referred to as a perm, curling agent, curling hair straightening agent, and the like, and when used in a two-part formulation, It may also be referred to as a first agent for perming, a first agent for curling hair straightening, and the like.
本發明毛髮處理劑之劑型並未限定至特定劑型，可舉例如以水為媒介之乳霜、凝膠、泡沫、噴液(spray)、霧狀(mist)、液狀等形態。The dosage form of the hair treatment agent of the present invention is not limited to a specific dosage form, and may include, for example, a cream, a gel, a foam, a spray, a mist, or a liquid in the form of water.
本發明之毛髮處理劑可做成直接使用之1劑式、或可做成以該毛髮處理劑與含有氧化劑之第2劑作為構成成分的2劑式。又，若不損及本發明毛髮處理劑之效果，亦可做成進一步與其他劑組合使用之3劑式、或多劑式。相同的，若不損及本發明毛髮處理劑之效果，可做成使用時調整式，亦即，使用之前才將該毛髮處理劑、或與該毛髮處理劑組合使用之第2劑與其他劑混合。The hair treatment agent of the present invention can be used as a one-part formulation or a two-part formulation containing the hair treatment agent and a second agent containing an oxidizing agent as constituent components. Moreover, if the effect of the hair treatment agent of this invention is not impaired, it can also be set as the three-dose type or multiple-dose type which can be used in combination with other agents. Similarly, if the effect of the hair treatment agent of the present invention is not impaired, it can be adjusted during use, that is, the hair treatment agent or the second agent and other agents used in combination with the hair treatment agent before use mixing.
本發明之毛髮處理劑可與以往之燙髮或捲縮毛髮矯直處理相同的來使用。又，本發明之毛髮處理劑在燙髮或捲縮毛髮矯直處理時，可使用冷式及加溫式之任一。The hair treatment agent of the present invention can be used in the same manner as conventional perming or curling hair straightening treatments. In the hair treatment agent of the present invention, any one of a cold type and a warming type can be used when perming or curling hair straightening treatment.
使用本發明毛髮處理劑並進行波浪設計、捲曲設計、拉直設計之形成等的毛髮變形(設計形成)時，通常是使用電棒(rod)、高溫整髮用夾(iron)、燙髮鉗等設計形成工具來進行，然亦可不一定要使用該等設計形成工具。又，使用本發明毛髮處理劑並進行了毛髮變形(設計形成)時，可進行使波浪、捲曲或拉直狀態呈半永久持續的毛髮變形(設計形成)。另外，前述所謂半永久持續的毛髮變形(設計形成)意指，在與通常之燙髮等同等的數次洗髮操作下，不會失去如前述之毛髮變形狀態。When the hair treatment agent of the present invention is used to perform hair deformation (design formation) such as wave design, curl design, and straightening design, it is generally designed using an electric rod (rod), a high-temperature hair dressing iron (iron), or a curling iron. Forming tools to carry out, but it is not necessary to use such design forming tools. In addition, when the hair treatment agent of the present invention is used and hair deformation (design formation) is performed, hair deformation (design formation) in which the wave, curl, or straightened state is semi-permanently continuous can be performed. In addition, the aforementioned semi-permanent hair deformation (design formation) means that the hair deformation state as described above will not be lost under several shampooing operations equivalent to ordinary perm.
本發明之燙髮或捲縮毛髮矯直處理方法特徵在於包含將上述毛髮處理劑應用到全部或一部分頭髮之步驟。The method of straightening or curling hair straightening treatment of the present invention is characterized by including the step of applying the above-mentioned hair treatment agent to all or part of the hair.
本發明方法當中，毛髮變形可在毛髮處理劑之塗布前、塗布中及塗布後之任一來進行。在毛髮變形使用之設計形成工具可舉前述之物。在本發明方法中，亦可在毛髮處理劑塗布中加溫，如此溫度可舉例如40~60℃。In the method of the present invention, hair deformation may be performed before, during and after application of the hair treatment agent. The design forming tool used for hair deformation may be the foregoing. In the method of the present invention, the temperature of the hair treatment agent may also be heated, and the temperature may be, for example, 40 to 60 ° C.
本發明方法當中，將毛髮處理劑應用到頭髮的時間可因應毛髮之髮質等來適宜設定，例如，10~30分鐘。毛髮處理劑在應用到毛髮上並使之反應適切的時間後，可利用水等來洗去。In the method of the present invention, the time for applying the hair treatment agent to the hair can be appropriately set according to the hair quality of the hair, for example, 10 to 30 minutes. After the hair treatment agent is applied to the hair and allowed to react for an appropriate period of time, it can be washed away with water or the like.
本發明方法中，當毛髮處理劑為2劑式時，可接續上述第1劑之步驟，實施將含有氧化劑之第2劑應用到全部或一部分頭髮之步驟。如此氧化劑可舉例如溴酸鹽(例如，鈉鹽、鉀鹽、銨鹽)、過硼酸鹽(例如，鈉鹽、鉀鹽、銨鹽)、過氧化氫等。氧化劑可單獨使用或2種以上混合使用。In the method of the present invention, when the hair treatment agent is a two-part formula, the step of the first agent can be continued, and the step of applying the second agent containing an oxidizing agent to all or part of the hair can be performed. Examples of such an oxidant include bromate (for example, sodium, potassium, and ammonium salts), perborate (for example, sodium, potassium, and ammonium salts), hydrogen peroxide, and the like. The oxidant can be used alone or in combination of two or more.
對頭髮應用第2劑之時間可因應毛髮之髮質等適宜設定，例如，10~15分鐘。第2劑在在應用到毛髮上並使之反應適切的時間後，可利用水等來洗去。The time for applying the second agent to the hair can be appropriately set according to the hair quality of the hair, for example, 10 to 15 minutes. The second agent can be washed off with water or the like after it has been applied to the hair for an appropriate time.
本發明之毛髮滲透促進劑可用於例如燙髮劑、捲曲劑、捲縮毛髮矯直劑、染毛劑、脫色劑等，當該等為2劑式時，可使用在第1劑及第2劑中任一。The hair permeation enhancer of the present invention can be used, for example, in a perm agent, a curling agent, a curled hair straightener, a hair dye, a decoloring agent, and the like. When these are two-agent type, they can be used in the first agent and the second agent. Either.
本發明之毛髮處理劑即便在少量摻合或不使用鹼性藥劑，且pH在中性區域之情況下，仍可達到與在弱~強鹼性情況下同等以上之形成波浪設計、捲曲設計、拉直設計等的設計形成效果。進一步，以往的毛髮處理劑含有鹼性藥劑而pH為鹼性，因此會損傷頭皮及頭髮的蛋白質而為刺激性，然本發明之毛髮處理劑含有已知是低刺激的烷基醚羧酸胺基酸鹽，因此會減少蛋白質之損傷而為低刺激性。The hair treatment agent of the present invention can achieve a wave-forming design, a curling design, and the like in the case of weak to strong alkaline even in the case of a small amount of blending or without using an alkaline agent, and the pH is in the neutral region. A design such as a straightened design is effective. Furthermore, the conventional hair treatment agent contains alkaline agents and the pH is alkaline, so it damages scalp and hair proteins and is irritating. However, the hair treatment agent of the present invention contains an alkyl ether carboxylic acid amine which is known to have low irritation. Basal acid salt, thus reducing protein damage and being less irritating.
又，本發明之毛髮滲透促進劑除了是低刺激之外，還具有優異的還原劑對毛髮之滲透促進作用。In addition, the hair permeation enhancer of the present invention has a low irritation and also has an excellent reduction permeation promotion effect on hair.
實施例 以下將舉實施例以更詳細說明本發明。但，本發明並未受到該等實施例等而被任意限定。EXAMPLES Examples will be given below to explain the present invention in more detail. However, the present invention is not arbitrarily limited by these examples and the like.
樣品之調製及獲得 本實施例所使用之烷基醚羧酸離胺酸、烷基醚羧酸組胺酸及烷基醚羧酸精胺酸是依照以下方法來調製進而獲得。Preparation and acquisition of samples The alkyl ether carboxylic acid lysine, alkyl ether carboxylic acid histamine, and alkyl ether carboxylic acid arginine used in this example were prepared according to the following methods.
・烷基醚羧酸離胺酸之調製 烷基醚羧酸離胺酸是將聚氧乙烯月桂醚醋酸(三洋化成工業股份有限公司製、商品名「BEAULIGHT LCA-25NH」)在離胺酸水溶液中進行中和來調製。・ Preparation of alkyl ether carboxylic acid lysineAlkyl ether carboxylic acid lysine is a solution of polyoxyethylene lauryl acetic acid (manufactured by Sanyo Chemical Industry Co., Ltd., trade name "BEAULIGHT LCA-25NH") in lysine solution Neutralize to modulate.
・烷基醚羧酸組胺酸之調製〕 烷基醚羧酸組胺酸是將聚氧乙烯月桂醚醋酸(三洋化成工業股份有限公司製、商品名「BEAULIGHT LCA-25NH」)在組胺酸水溶液中進行中和來調製。[Preparation of alkyl ether carboxylic acid histamine]] Alkyl ether carboxylic acid histamine is made of polyoxyethylene lauryl acetic acid (manufactured by Sanyo Chemical Industry Co., Ltd. under the trade name "BEAULIGHT LCA-25NH") It is prepared by neutralization in an aqueous solution.
・烷基醚羧酸精胺酸之調製〕 烷基醚羧酸精胺酸是將聚氧乙烯月桂醚醋酸(三洋化成工業股份有限公司製、商品名「BEAULIGHT LCA-25NH」)在精胺酸水溶液中進行中和來調製。・ Preparation of alkyl ether carboxylic acid arginine] Alkyl ether carboxylic acid arginine is a compound of polyoxyethylene lauryl acetic acid (manufactured by Sanyo Chemical Industry Co., Ltd., trade name "BEAULIGHT LCA-25NH") It is prepared by neutralization in an aqueous solution.
實施例所採用之毛髮處理劑是以烷基醚羧酸胺基酸鹽[摻合於表2及3所示之量]、還原劑[摻合於表2及3所示之量]、金屬封鎖劑[對毛髮處理劑總質量摻合0.01質量%之純成分60質量%的艾提壯酸(etidronic acid)]、pH調整劑(精胺酸)及離子交換水所構成之物。此外，烷基醚羧酸胺酸鹽是使用上述3種的混合物。The hair treatment agent used in the examples is an alkyl ether carboxylic acid amino salt [amount blended in Tables 2 and 3], a reducing agent [amount blended in Tables 2 and 3], metal Blocking agent [mixed with 0.01% by mass of pure ingredients and 60% by mass of etidronic acid], a pH adjuster (spermine) and ion-exchanged water. As the alkyl ether carboxylic acid amine salt, a mixture of the above three types was used.
使用前述毛髮處理劑，並進行下述之捲曲設計形成測試。該評價結果顯示在以下之表2及3。The aforementioned hair treatment agent was used, and a curl design formation test described below was performed. The evaluation results are shown in Tables 2 and 3 below.
捲曲設計形成效果之評價方法 將每20根約20 cm的未處理人毛做成1束，將該毛束捲到Kirby rod(キルビーロッド)上，並均勻塗布各實施例或比較例之毛髮處理劑5 ml。在室溫下放置30分後，均勻塗布下述之燙髮2劑5 ml。塗布15分後進行水洗。將毛束自Kirby rod取下，並直接以潮濕的狀態進行捲曲形成力的評價。捲曲形成力是根據以下式算出的波浪效率來評價。Method for evaluating the effect of the formation of a curl design One bundle of 20 untreated human hairs each having a length of about 20 cm was rolled onto a Kirby rod (キ ル ビ ー ロ ッ ド), and the hair treatment of each example or comparative example was evenly coated. 5 ml. After standing at room temperature for 30 minutes, 5 ml of the following two permanent waves were evenly applied. After coating for 15 minutes, it was washed with water. The hair bundles were removed from the Kirby rod, and the curl formation force was evaluated directly in a wet state. The curl forming force was evaluated based on the wave efficiency calculated by the following formula.
波浪效率(%)＝100-(100×(B-A))/(C-A) A：Kirby rod器具之第1至第6棒的距離(30 mm) B：所形成之波浪的5個峰的距離(X mm) C：將B拉直時的距離(100 mm)Wave efficiency (%) = 100- (100 × (BA)) / (CA) A: The distance from the 1st to the 6th rod of the Kirby rod (30 mm) B: The distance of the 5 peaks of the formed wave ( X mm) C: Distance when straightening B (100 mm)
在捲曲設計形成效果之評價方法所使用之燙髮2劑：Two methods of perm used in the evaluation method of the curl design formation effect:
[表1] [Table 1]
捲曲形成力越高，越可形成具立體感且具穩固彈力的捲曲，即便拉長延伸，仍可馬上回復原本的捲曲狀態。另一方面，隨著捲曲形成力變低，彈力會消失，而捲曲會變鬆弛，若拉長延伸，則捲曲狀態會變得更鬆弛。進一步，若捲曲形成力變低，則會變得無法形成捲曲。The higher the curl forming force, the more three-dimensional and stable elastic curl can be formed. Even if it is stretched and extended, the original curl state can be restored immediately. On the other hand, as the curl forming force becomes lower, the elastic force disappears, and the curl becomes loose, and if the stretch is extended, the curl state becomes more relaxed. Further, if the curl-forming force becomes low, it becomes impossible to form a curl.
結果 實施主要是在探討半胱胺的波浪效率Results The implementation was mainly to explore the wave efficiency of cysteamine
[表2] [Table 2]
[表3] [table 3]
在上述實施例中，在評價摻合了半胱胺及烷基醚羧酸胺基酸鹽之毛髮處理劑的波浪效率後，相較於未摻合烷基醚羧酸胺基酸鹽之比較例1，波浪效率皆有提升。In the above examples, after evaluating the wave efficiency of a hair treatment agent blended with cysteamine and an alkyl ether carboxylic acid amino acid salt, the comparison with the non-doped alkyl ether carboxylic acid amino acid salt Example 1. Wave efficiency has improved.
又，相較於使用在一般還原劑之中設計形成作用最高的氫硫乙酸鹽，且位於鹼性區域之比較例2，pH為中性區域之實施例的毛髮處理劑可獲得同等以上的波浪效率。In addition, compared with the comparative example 2 in which the hydrothioacetate which is designed to form the most effective reducing agent is used and is located in the alkaline region, the hair treatment agent of the example in which the pH is in the neutral region can obtain an equivalent wave or more. effectiveness.
從上述實驗結果可知，使用烷基醚羧酸胺基酸鹽作為毛髮處理劑用之毛髮滲透促進劑時，在提升波浪效率之同時，即便不透過鹼性藥劑將pH調整到弱~強鹼而是中性區域，仍可達到與鹼性區域相同的效果，而可提供一種可解決因鹼性藥劑所致對毛髮及頭皮之刺激的毛髮處理劑。From the results of the above experiments, it can be seen that when alkyl ether carboxylic acid amino salt is used as a hair penetration enhancer for hair treatment agents, while improving wave efficiency, even if the pH is adjusted to weak to strong alkali without passing through alkaline agents, It is a neutral area, and can still achieve the same effect as an alkaline area, but can provide a hair treatment agent that can solve the irritation of hair and scalp caused by alkaline agents.
處方例 以下顯示本發明毛髮處理劑之處方例。Formulation Examples The following shows examples of the hair treatment agent of the present invention.
・處方例1 ・ Prescription example 1
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