TW201806602A - Inflammation and sore resistant medicine for oral soft tissue (gum, mucous membrane) capable of having multiple efficacies in one medicine - Google Patents

Abstract

This invention relates to an inflammation and sore resistant medicine for oral soft tissue (gum, mucous membrane) which is a mixture containing one or more adrenocorticotropic hormones or anti-inflammatory inhibiting compounds, one or more adhesive polymers having long term adhesion, one filling and repairing agent, and one or more additives, wherein the content of adrenocorticotropic hormones or anti-inflammatory inhibiting compounds is 0.5-2 mass percent; the content of the adhesive polymers is 1-4.5 mass percent; the content of the filling and repairing agent is 35-45 mass percent; the content of the additives is 30-50 mass percent; and the potential of hydrogen value index (PH) of the mixture is 6-8.5.

Description

Oral Soft Tissue (Gum, Mucosa) Anti-Inflammation Agent

The invention provides the technical field of an anti-inflammatory sore agent, in particular, it technically provides an anti-inflammatory sore agent for oral soft tissue (gingival, mucosa).

The conventional knowledge is not the same or similar to the present inventor, and here is an example of the conventional patent specification for oral cavity. For example, its application No. 102142948 "Medical use of intraoral gum composition kit" includes mouthwash, which contains water, sodium bicarbonate, sodium saccharin, and trace amounts of menthol and food color blue No.1, the gel in the mouth forms a film to protect the oral mucosa in the oral cavity, which can reduce external stimuli, thereby protecting the mucous membranes that cause oral ulcers in any way, and slowing the severe pain caused by direct contact of the mucous membranes. Wherein the oral coagulant comprises water, polyvinylpyrrolidone K-90, calcium chloride, dipotassium glycyrrhizinate, benzalkonium chloride, disodium ethylenediaminetetraacetate, potassium sorbate, and propylene glycol; and, It can be used directly or diluted with water with different composition ratios. However, polyvinylpyrrolidone K-90 has the functions of detoxification, hemostasis, increase of dissolved concentration, prevention of peritoneal adhesion, and promotion of erythrocyte sedimentation. Calcium is an introduction agent, although it can accelerate calcification of bones and teeth, Excessive calcification can easily lead to excessive brittleness of the teeth, which can easily break down. It can also cause excessive activation of oral muscles, which can cause imbalance or weakness of the basal muscles, especially those who are more sensitive to calcium chloride and are not suitable for use. . However, benzalkonium chloride is a commonly used disinfectant, and the standard concentration range is 0.004% to 0.01%. Excessive concentration will cause corrosiveness, but it cannot achieve the effect of calming and anti-inflammatory. And saccharin sodium is more likely to cause cancer concerns and risks.

However, the aforementioned previous case is used in the form of two doses, and the aforementioned prior case is used as an oral ulcer. The present invention is in the form of a dose. The present invention is used as an anti-inflammatory sore for oral soft tissues (gum, mucous membranes). The present invention is different from the conventional one.

Therefore, in view of the problems existing in the above-mentioned conventional preparations, how to develop an innovative preparation with more ideal practicability is eagerly awaited by consumers, and it is also the goal and direction for relevant industry players to work hard to make breakthroughs.

In view of this, the inventor has been engaged in the manufacturing development and design of related products for many years. In view of the above-mentioned goals, after detailed design and careful evaluation, the present invention is indeed practical.

The main object of the present invention is to provide an anti-inflammatory sore agent for oral soft tissues (gum, mucous membranes), which comprises one or more adrenocorticotropic hormones or anti-inflammatory inhibitory compounds, one or more adhesive polymers with long-lasting adhesion, and one kind of filling repair Agent and one or more additives into a mixture; wherein the aforementioned adrenocorticotropic hormone or anti-inflammatory inhibitory compound contains The content is 0.5 to 2 mass percent; the content of the aforementioned adhesive polymer is 1 to 4.5 mass percent; the content of the aforementioned filling and repairing agent is 35 to 45 mass percent; the content of the aforementioned additive is 30 to 50 mass percent; and the pH index of the mixture is PH6 ~ 8.5.

To achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissue (gingival, mucosa), wherein the aforementioned adrenocorticotropic hormone or anti-inflammatory inhibitory compound comprises a compound selected from 3 β-hydroxy-11-oxy-12-oleanolene -30-acid, (20 β) -3 β-hydroxy-11-oxyorion-12-oleanolene-29-acid, (3 β, 20 β) -3-hydroxy-11-oxy-12- Oleanene-29-acid, deoxyglycyrrhetic acid, 18 β-glycyrrhetic acid, 18-α-droxyglycyrrhetic acid, dihydroxyglycyrrhetic acid acid is one or more of the group consisting of grabric acid and liquiritic acid compounds.

In order to achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissue (gum, mucous membrane), wherein the adhesive polymer includes a thickener and a silicate compound, and the thickener is (Sodium Carboxymethyl Cellulose, referred to as NaCMC) ) Sodium carboxymethyl cellulose, the content of the thickener is 0.5 to 2.5 mass percent, the silicate compound is (SiO2) silicon dioxide, and the content of the silicate compound is 0.5 to 2 mass percent.

In order to achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissues (gingival, mucosa), wherein the aforementioned filling and repairing agent is calcium carbonate (CaCO ₃ ).

To achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissue (gingival, mucosa), wherein the aforementioned additives may include propane-1,2,3-triol glycerol (glycerin), (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (menthol) and mixed water (Purified Water) mixed additive, in which the aforementioned propane-1 The content of 2,3,3-triol glycerol (glycerin) is 30 to 40% by mass; the aforementioned (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2-isopropanol The content of -5-methylcyclohexanol (menthol) is 0.3 to 1.3 mass percent.

In order to achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissue (gum, mucous membrane), wherein the aforementioned additive may include more than one additive polymer, and the aforementioned additive polymer includes 4-allyl-2-methoxyphenol (Eugenol eugenol) or Propyl paraben.

In order to achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissues (gum, mucous membranes), wherein the aforementioned additives may include sodium lauryl sulfate (Sodium Lauryl Sulfate), and the content of the aforementioned sodium lauryl sulfate is 0.5 ~ 3.5 mass percent.

In order to achieve the above object, the present invention provides an anti-inflammatory sore agent for oral soft tissue (gingival, mucosa), wherein the aforementioned additive may include a fluorine compound.

Regarding the technology, means and effects adopted by the present invention, a preferred embodiment will be described in detail with reference to the drawings. It is believed that the above-mentioned objects, structures, and characteristics of the present invention can be understood thoroughly and in detail. .

The invention provides a designer of an anti-inflammatory sore agent for oral soft tissues (gum, mucosa).

In order to allow your reviewers to further understand and understand the purpose, features and effects of the present invention, the following detailed description is given in conjunction with the embodiments and drawings: The present invention provides an oral inflammatory soft tissue (gum, mucosa) anti-inflammatory sore agent, The system comprises: one or more adrenocorticotropic hormones or anti-inflammatory inhibitory compounds, one or more adhesive polymers with long-lasting adhesion, one filling repair agent and one or more additives; a mixture of the aforementioned adrenocorticotropic hormones or The content of the inflammation-inhibiting compound is 0.5 to 2% by mass; the content of the aforementioned adhesive polymer is 1 to 4.5% by mass; the content of the aforementioned filling and repairing agent is 35 to 45% by mass; the content of the aforementioned additive is 30 to 50% by mass; The base number index is PH6 ~ 8.5.

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the aforementioned adrenocorticotropic hormone or anti-inflammatory inhibitory compound comprises Selected from 3 β-hydroxy-11-oxy-12-oleanolene-30-acid, (20 β) -3 β-hydroxy-11-oxolian-12-oleanolene-29-acid, ( 3 β, 20 β) -3-hydroxy-11-oxy-12-oleanolene-29-acid, deoxyglycyrrhetic acid, 18 β-glycyrrhetic acid, 18-α-hydroxyglycyrrhetin One or more of the Glycyrrhetinic acid (Enoxolone) group consisting of 18-α-droxyglycyrrhetic acid, dihydroxyglycyrrhetic acid (grabric acid) and liquiritic acid compound.

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the adhesive polymer includes a thickener and a silicate compound, and the thickener is (Sodium Carboxymethyl Cellulose (NaCMC)) carboxymethyl fiber The content of the thickener is 0.5 to 2.5 mass percent, the content of the silicate compound is (SiO ₂ ) silicon dioxide, and the content of the aforementioned silicate compound is 0.5 to 2 mass percent.

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the aforementioned filling and repairing agent is calcium carbonate (CaCO ₃ ).

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the aforementioned additive may include propane-1,2,3-triol glycerol (glycerin), (1R, 2S, 5R) -2-isopropyl- 5-methylcyclohexanol (1R, 2S, 5R) -2-isopropanol-5-methylcyclohexanol (menthol) and mixed water (Purified Water) mixed additive, wherein the aforementioned propane-1,2,3- The content of triol glycerol (glycerin) is 30 to 40 mass percent; The content of (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2-isopropanol-5-methylcyclohexanol (menthol) is 0.3 to 1.3 mass percent. Purified Water is the humidity regulating effect of the present invention.

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the aforementioned additive may include more than one additive polymer, and the aforementioned additive polymer includes 4-allyl-2-methoxyphenol (Eugenol eugenol) Or Propyl paraben.

The oral soft tissue (gingival, mucous membrane) anti-inflammatory sore agent, wherein the aforementioned additive may include Sodium Lauryl Sulfate, and the content of the aforementioned Sodium Lauryl Sulfate is 0.5 to 3.5 mass percent.

The oral soft tissue (gingival, mucosal) anti-inflammatory sore agent, wherein the aforementioned additive may include a fluorine compound.

The invention can be mainly used for the restoration, hyperplasia, anti-inflammatory, bactericidal, anti-inflammatory and other effects of gum, oral mucosa, peri-implantitis, and periodontal-related diseases. It also has the effect of anti-viral infection and carcinogenic viruses such as hepatitis Virus, Epstein-Barr virus, and AIDS infections all have inhibitory effects, and are similar to antibiotics in their pharmacology. They are used to treat infections of Staphylococcus, Streptococcus, E. coli, Helicobacter, etc. to a certain extent. . Its chemical structure is similar to corticosteroids. Glycyrrhetic acid can still produce sodium retention and antidiuretic and anti-inflammatory effects in animals with adrenal cortex and pituitary resection, that is, glycyrrhetic acid inhibits the destruction of adrenal corticosteroids in the body. It is bad, so the content of corticosteroids in the blood increases correspondingly, and it shows a more obvious adrenocortical hormone-like effect, and also has anti-inflammatory effects of butapine (benzozoline) or hydrocortisone. It has inhibitory effects on cotton ball granulomas, formaldehyde-induced foot swelling, and subcutaneous granulomatous inflammation. Its anti-inflammatory potency is about 1/10 of cortisone or hydrocortisone, so its pharmacological properties are good for gums and oral mucosa , Peri-implantitis, periodontal and other related disease symptoms have a good inhibitory effect.

Calcium Carbonate is mainly used for removing stains and scrubs to fill the dentinal pores. It is an anti-allergy and acid-resistant filler. Calcium carbonate is an inorganic compound commonly known as limestone, limestone, stone powder, marble, and calcite. It is a compound with a chemical formula of CaCO _3. It is alkaline, basically insoluble in water, and soluble in acids. It is a common material on the earth and exists in rocks such as vermiculite, calcite, chalk, limestone, marble, and travertine. Or the main component of animal bones or shells. It is also a commonly used source of calcium. It is also often used as one of the active ingredients in acid suppressants. Because it is a source of calcium, after grinding into powder, The matte surface has a good stain removal effect, which can effectively prevent calculus. In addition, it can fill the dentinal pores and completely cover the dentinal pores. It can effectively avoid the exposure of the dental nerve in the dentinal pores. I feel sore and tender when I am stimulated by hot and cold food. It is frosted and stain-removed. At the same time, it is combined with the adhesive polymer of Sodium Carboxymethyl Cellulose (NaCMC) sodium carboxymethyl cellulose and (SiO ₂ ) silicon dioxide. The protective layer is an effective anti-allergy and acid-resistant filler.

Sodium Carboxymethyl Cellulose (NaCMC for short) is the sodium salt of cellulose carboxymethyl ether. It is a white or milky white fibrous powder or granule, which is odorless, tasteless and hygroscopic. Easily dispersed in water to form a clear gelatinous liquid, insoluble in organic solvents such as ethanol. The pH of 1% aqueous solution is 6.5 ~ 8.5. When the pH is> 10 or <5, the viscosity of the glue is significantly reduced, and the performance is best at pH7. It is thermally stable, its viscosity rises rapidly below 20 ° C, and it changes slowly at 45 ° C. Long-term heating above 80 ° C can make its colloid denaturate and its viscosity drop significantly. The browning temperature is 226 ~ 228 ° C, and the carbonization temperature is 252 ~ 253 ° C. It is odorless, tasteless and hygroscopic. Easily dispersed in water to form a clear gelatinous liquid, insoluble in organic solvents such as ethanol. According to the "National Food Safety Standards, Standards for the Use of Food Additives" (GB2760-2011), thickeners are used in food. Carboxymethylcellulose sodium (NaCMC) has unusual and valuable comprehensive physical and chemical properties such as emulsifying and dispersing agents, solid dispersibility, not easy to spoil, and physiologically harmless. It is the largest yield and application of cellulose ethers. The most widely used and most convenient product, commonly known as "industrial monosodium glutamate" important characteristics are the formation of high-viscosity colloids, solutions, adhesion, thickening, flow, emulsification and dispersion, shaping, water retention, protective colloids, film forming, acid resistance, It is resistant to salt, turbidity, and physiologically harmless, so it is widely used in food, medicine, daily chemical, petroleum, paper, textile, construction and other fields. In this anti-inflammatory sore agent, it is a thickener, which provides the effect of drug attachment, and combines with Silicone Dioxide to make It produces a certain viscosity, and then forms a gel or paste. This medicine can be used to apply ointment, form a protective film on the affected area, or use in the state of toothpaste.

Silicone Dioxide is an anti-caking agent and thickener. The network structure of SiO ₂ determines that it has excellent physical and chemical properties. In addition, the widespread presence of SiO ₂ in nature has been widely used by humans from ancient times to the present. Silicon dioxide and other compounds are melted at high temperatures and rapidly cooled to make glass. It is also the main constituent of sand and quartz. It is currently the main raw material in applications such as semiconductors and solar panels. It is used as an anti-caking agent in the food industry and belongs to the category of food additives. It is used to prevent adhesion between food and food or between food and packaging. May be added to any powdered seasoning, brewing bag, salt, sliced cheese, etc. Because this mineral powder is extremely fine, it has a lubricating effect. Therefore, the powder can be maintained in a loose state without agglomeration. In addition, its medical function is a cross-linking agent, which can provide strength and flexibility to make collagen and connective tissue elastic. Silicon dioxide is being studied. It has been shown to play an integral role in bones, arterial walls, skin, teeth, gums, hair and nails and is used to relieve eczema and psoriasis. Research is currently determining the role of silica in rheumatic and arterial disease. Silicon dioxide can prevent osteoporosis and strengthen the musculoskeletal system, so it can avoid many injuries. It can also accelerate the healing of fractures. Silicon dioxide can help the formation of structural matrix and repair connective tissue. The accumulation of minerals in the matrix is Helps the growth of the human body. Silicon dioxide is fundamental, in osteoblasts it is responsible for calcium deposition and the phosphoprotein matrix of the bone. Studies have shown that skeletal diseases such as osteochondrosis (cartilage) and osteoporosis (or spontaneous fractures), although caused by insufficient calcium, cannot be treated with calcium alone. Calcium plus silicon dioxide has a good effect. Therefore, with calcium carbonate, it has excellent anti-sensitivity and acid resistance in filling dentin pores or forming a protective layer on the surface.

Glycerin (propane-1,2,3-triol) is glycerin, which is a water retaining agent and antifreeze. Glycerol is the backbone component of triglyceride molecules. When the human body consumes edible fat, the triglycerides in it are metabolized in the body to form glycerol and stored in fat cells. Therefore, the final products of triglyceride metabolism are glycerol and fatty acids. It can be used as solvents, lubricants, medicaments and sweeteners. It is a colorless, odorless, sweet, viscous liquid with a specific gravity of 1.2613 (20/4 °) and a boiling point of 290 ° C. It can be miscible with water in any proportion, has great hygroscopicity, slightly soluble in ethanol and ether, and insoluble in chloroform. Glycerin can be used to make nitroglycerin, alkyd resin, etc. It can also be used as an antifreeze for aircraft and automobile liquid fuels, plasticizers for glass and paper, and hygroscopic agents for cosmetics, leather, tobacco, and textiles. It can be used to preserve specimens in the laboratory. It has a sweet taste and can have a good taste and lubricity when applied to the affected part of the oral cavity.

(1R, 2S, 5R) -2-isopropanol-5-methylcyclohexanol is Menthol menthol: it is cool, calm, refreshes the breath and deodorizes. Menthol is made in the leaves of mint, which is the main component of peppermint oil. A monoterpenoid. It is a highly volatile essential oil produced by plants. Its components are mostly semiterpenes, monoterpenes and sesquiterpenes, and its yield is higher especially in warm climates. Some important plant pigments are terpenoids or terpenoid-containing compounds. It has antipruritic, analgesic, antiseptic, irritating, narcotic, cooling and anti-inflammatory effects. It can cure headaches, neuralgia, pruritus and inflammation of the respiratory tract, atrophic rhinitis, hoarseness, etc., and can eliminate odors, so that this agent can enhance its comfortability.

4-Allyl-2-methoxyphenol is Eugenol Eugenol: it is an organic compound that exists in many plants and is rich in its essential oils, such as laurel oil. Has a long-lasting aroma and is often used as a perfume for soap. Colorless to pale yellow slightly thick liquid with strong lilac odor. It is mainly used for antibacterial, lowering blood pressure and local anesthetics. It is also used to make perfumes, fragrances, essential oils, modifiers and fixatives. It can be used in combination with the main agent glycyrrhetic acid to achieve rapid anti-inflammatory and antibacterial effects. It also has the characteristics of local anesthesia, which can make oral soft tissues (gum, mucosa) feel soothing and analgesic quickly. It can also be used for dental caries, and it also has local antiseptic effect. It is one of the best additives to increase efficacy and increase comfort and body feel.

Propyl paraben is a type of preservative used in the cosmetics and pharmaceutical industries. It is also commonly used in food additives. Its salts and compounds were originally used as bactericides and fungicides. These compounds are commonly used in shampoos, commercial body creams, shaving creams, human lubricants, topical medicines, spray solvents, cosmetics and toothpastes. It has a wide range of antibacterial effects against mold, yeast and bacteria. Make this agent improve its antiseptic ability and Solubility.

Sodium Lauryl Sulfate, also known as Sodium dodecyl sulfate, is one of the commonly used surfactants, is an anionic surfactant, and is a typical representative of sulfate surfactants. Slightly soluble in alcohol, insoluble in chloroform and ether, easily soluble in water, good compatibility with anions and non-ions, good emulsification, foaming, foaming, penetration, decontamination and dispersion properties, rich foaming Fast biodegradation, widely used in toothpaste, soap, bath milk, shampoo, washing powder, and foaming agent in cosmetics. It can be used as a degreasing and cleaning effect with the calcium carbonate filling repair agent, so that after removing the oral cavity dirt, it can repair and protect the calcium carbonate filling repair agent.

The foregoing is a detailed description of the technical features of the present invention with reference to the preferred embodiments of the present invention; however, those skilled in the art can make changes and modifications to the present invention without departing from the spirit and principles of the present invention, and the Such changes and modifications shall all be covered by the scope defined by the scope of patent application below.

In summary, the present invention provides an anti-inflammatory sore agent for oral soft tissues (gum, mucous membranes), which has indeed achieved all the purposes of the present invention. In addition, the spatial configuration of its combined structure has not been seen in similar products and has not been disclosed in the application. Before, it had already met the requirements of the Patent Law, and filed an application in accordance with the law.

Claims (4)

An oral inflammatory soft tissue (gingival, mucosal) anti-inflammatory sore agent, comprising: one or more adrenocorticotropic hormones or anti-inflammatory inhibitory compounds, one or more adhesive polymers with long-lasting adhesion, one filling repair agent, and one or more additives mixed Into a mixture; wherein the content of the aforementioned adrenocorticotropic hormone or anti-inflammatory inhibitory compound is 0.5 to 2 mass percent; the content of the aforementioned adhesive polymer is 1 to 4.5 mass percent; the content of the filling and repairing agent is 35 to 45 mass percent; the aforementioned additive The content is 30 to 50% by mass, and the pH value index of the aforementioned mixture is PH6 to 8.5; wherein the aforementioned adrenocorticotropic hormone or anti-inflammatory inhibitory compound comprises a compound selected from 3 β-hydroxy-11-oxy-12-oleanolene-30 -Acid, (20 β) -3 β-hydroxy-11-oxyolian-12-oleanolene-29-acid, (3 β, 20 β) -3-hydroxy-11-oxy-12-olean Fruitene-29-acid, deoxyglycyrrhetic acid, 18 β-glycyrrhetic acid, 18-α-droxyglycyrrhetic acid, dihydroxyglycyrrhetic acid grabric acid) and liquiritic ac id) One or more of the Enoxolone group composed of compounds; wherein the adhesive polymer includes a thickener and a silicate compound, and the thickener is (NaCMC) carboxymethyl The content of cellulose sodium, the thickener is 0.5 to 2.5 mass percent, and the silicate compound is (SiO2) Silicon dioxide, the content of the aforementioned silicate compounds is 0.5 to 2% by mass; wherein the aforementioned filling and repairing agent is calcium carbonate (CaCO3); wherein the aforementioned additive may include propane-1,2,3-triol glycerol (Glycerin), (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R, 2S, 5R) -2-isopropanol-5-methylcyclohexanol (menthol) and purified water (Purified Water ) Mixed additives, wherein the content of the propane-1,2,3-triol glycerol (glycerin) is 30-40% by mass; the aforementioned (1R, 2S, 5R) -2-isopropyl-5-methylcyclohexanol (1R The content of 2S, 5R) -2-isopropanol-5-methylcyclohexanol (menthol) is 0.3 to 1.3 mass percent. An anti-inflammatory sore agent for oral soft tissues (gum, mucous membranes) according to item 1 of the scope of the patent application, wherein the aforementioned additive may include more than one additive polymer, and the aforementioned additive polymer includes 4-allyl-2-methoxy Eugenol eugenol or Propyl paraben. An anti-inflammatory sore agent for oral soft tissue (gingival, mucosa) according to item 1 of the scope of the patent application, wherein the aforementioned additive may include Sodium Lauryl Sulfate, and the content of the aforementioned Sodium Lauryl Sulfate is 0.5 ~ 3.5 mass percentage. The oral soft tissue (gum, mucosa) anti-inflammatory sore agent according to item 1 of the scope of the patent application, wherein the aforementioned additive may include a fluorine compound.