TW201637648A - 淚腺藥物遞輸系統 - Google Patents

淚腺藥物遞輸系統 Download PDF

Info

Publication number: TW201637648A
Authority: TW; Taiwan
Prior art keywords: drug; lacrimal gland; percutaneous absorption; preparation; administration
Prior art date: 2015-04-03

Application number

TW105110450A

Other languages

English (en)

Chinese (zh)

Inventor

隱樹健二

淺田博之

宮崎達也

稻垣孝司

Original Assignee

參天製藥股份有限公司

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-04-03

Filing date

2016-04-01

Publication date

2016-11-01

2016-04-01 Application filed by 參天製藥股份有限公司 filed Critical 參天製藥股份有限公司

2016-11-01 Publication of TW201637648A publication Critical patent/TW201637648A/zh

Links

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HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Emergency Medicine (AREA)
Dispersion Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

TW105110450A 2015-04-03 2016-04-01 淚腺藥物遞輸系統 TW201637648A (zh)

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JP2015076890		2015-04-03

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JP (1)	JP2016196454A (es)
AR (1)	AR104177A1 (es)
TW (1)	TW201637648A (es)
WO (1)	WO2016159351A1 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN111372564A (zh) *	2017-11-21	2020-07-03	艾克瑟罗视觉股份有限公司	用于治疗眼周分泌腺中或眼表上的异常发炎的组合物和方法
US11759472B2 (en)	2017-11-21	2023-09-19	Cs Pharmaceuticals Limited	Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9102340D0 (sv) *	1991-08-13	1991-08-13	Astra Ab	Pharmaceutical composition containing carbachol and othercholinergic substances
EP1754491B1 (en) *	2004-05-21	2010-03-03	Senju Pharmaceutical Co., Ltd.	Ophthalmic percutaneously absorbed preparation containing muscarinic receptor agonist
CA2958665C (en) *	2007-10-19	2021-03-02	Sarcode Bioscience Inc.	Compositions and methods for treatment of diabetic retinopathy
CA2719453A1 (en) *	2008-03-26	2009-10-01	Eric Donnenfeld	Methods for improving lid margin and tear film function and treatment of lid margin disease using tetracycline family antibiotics

2016
- 2016-04-01 AR ARP160100898A patent/AR104177A1/es unknown
- 2016-04-01 JP JP2016073887A patent/JP2016196454A/ja active Pending
- 2016-04-01 WO PCT/JP2016/060928 patent/WO2016159351A1/ja not_active Ceased
- 2016-04-01 TW TW105110450A patent/TW201637648A/zh unknown

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN111372564A (zh) *	2017-11-21	2020-07-03	艾克瑟罗视觉股份有限公司	用于治疗眼周分泌腺中或眼表上的异常发炎的组合物和方法
US11759472B2 (en)	2017-11-21	2023-09-19	Cs Pharmaceuticals Limited	Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
US12350277B2 (en)	2017-11-21	2025-07-08	Cs Pharmaceuticals Limited	Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface

Also Published As

Publication number	Publication date
AR104177A1 (es)	2017-07-05
WO2016159351A1 (ja)	2016-10-06
JP2016196454A (ja)	2016-11-24

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ES2759781T3 (es)	2020-05-12	Composiciones y tratamiento para enfermedades y trastornos oculares
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US11759472B2 (en)	2023-09-19	Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
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US12350277B2 (en)	2025-07-08	Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface
JP6861634B2 (ja)	2021-04-21	眼疾患を処置するための組成物及び方法
TW201637648A (zh)	2016-11-01	淚腺藥物遞輸系統
WO2025131038A1 (en)	2025-06-26	Compositions and methods for delivery of pharmaceutical actives
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OA19529A (en)	2020-11-13	Compositions and methods for treating aberrant inflammation in peri - ocular secretory glands or at the ocular surface.
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