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TW201612183A - Diaryl macrocycles as modulators of protein kinases - Google Patents

Diaryl macrocycles as modulators of protein kinases

Info

Publication number
TW201612183A
TW201612183A TW104107098A TW104107098A TW201612183A TW 201612183 A TW201612183 A TW 201612183A TW 104107098 A TW104107098 A TW 104107098A TW 104107098 A TW104107098 A TW 104107098A TW 201612183 A TW201612183 A TW 201612183A
Authority
TW
Taiwan
Prior art keywords
modulators
protein kinases
macrocycles
diaryl
diaryl macrocycles
Prior art date
Application number
TW104107098A
Other languages
Chinese (zh)
Other versions
TWI688567B (en
Inventor
Jingrong Jean Cui
Yishan Li
Evan W Rogers
Dayong Zhai
Original Assignee
Tp Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tp Therapeutics Inc filed Critical Tp Therapeutics Inc
Publication of TW201612183A publication Critical patent/TW201612183A/en
Application granted granted Critical
Publication of TWI688567B publication Critical patent/TWI688567B/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.
TW104107098A 2014-09-11 2015-03-05 Diaryl macrocycles as modulators of protein kinases TWI688567B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462049326P 2014-09-11 2014-09-11
US62/049,326 2014-09-11
US201562106301P 2015-01-22 2015-01-22
US62/106,301 2015-01-22

Publications (2)

Publication Number Publication Date
TW201612183A true TW201612183A (en) 2016-04-01
TWI688567B TWI688567B (en) 2020-03-21

Family

ID=56360757

Family Applications (2)

Application Number Title Priority Date Filing Date
TW104107098A TWI688567B (en) 2014-09-11 2015-03-05 Diaryl macrocycles as modulators of protein kinases
TW109104720A TWI736134B (en) 2014-09-11 2015-03-05 Diaryl macrocycles as modulators of protein kinases

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW109104720A TWI736134B (en) 2014-09-11 2015-03-05 Diaryl macrocycles as modulators of protein kinases

Country Status (1)

Country Link
TW (2) TWI688567B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111182903A (en) * 2017-07-28 2020-05-19 特普医药公司 Macrocyclic compounds and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011002470A (en) * 2008-09-08 2011-04-05 Merck Patent Gmbh Macrocyclics pyrimidines as aurora kinase inhibitors.
WO2011146336A1 (en) * 2010-05-20 2011-11-24 Array Biopharma Inc. Macrocyclic compounds as trk kinase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111182903A (en) * 2017-07-28 2020-05-19 特普医药公司 Macrocyclic compounds and their uses

Also Published As

Publication number Publication date
TWI736134B (en) 2021-08-11
TWI688567B (en) 2020-03-21
TW202035425A (en) 2020-10-01

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