TW201307319A - Insecticidal compounds - Google Patents

Abstract

The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests wherein A1, A2, A3, A4, R1, G1, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof.

Description

Insecticidal compound

The present invention relates to a novel triazole derivative having insecticidal activity and a method and an intermediate thereof for preparing the same, comprising an insecticidal, acaricidal, nematicidal or molluscicidal composition thereof, and using the same for controlling and controlling insects and cockroaches , a method of nematode or mollusc pests.

Accordingly, the present invention provides a compound of formula (I) Wherein A ¹ , A ² , A ³ and A ⁴ are each independently CX or nitrogen, wherein each X may be the same or different; R ¹ is hydrogen, C ₁ -C ₄ alkyl, H ₂ NC(O)- C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylcarbonyl; R ² is hydrogen, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₆ haloalkyl or cyano; G ¹ is oxygen or sulfur X is hydrogen, halogen, cyano, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl; Q ¹ is aryl or heterocyclic, each optionally substituted by one to five R ³ substituents, such substituents may be the same or different; or Q ¹ is C ₁ -C ₈ alkyl or substituted by one to five R ⁴ C ₁ -C ₈ alkyl, C ₂ -C ₈ alkenyl group or by one to five R ⁴ is a substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or ₂ -C ₈ alkynyl group substituted by one to five R is C ^4, C ₃ -C ₁₀ cycloalkyl or C ₃ -C ₁₀ cycloalkyl R ³ substituted by one to five R ⁴ is selected from the group consisting of cyano, amine, nitro, hydroxy, halogen, C ₁ -C ₄ alkyl, C ₁ - C ₄ haloalkyl, C ₂ -C ₄ alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, C ₂ -C ₄ haloalkynyl, C ₃ -C ₆ cycloalkyl, C _3- C ₆ halocycloalkyl, C ₁ -C ₃ alkoxy, C ₁ -C ₃ haloalkoxy, C ₁ -C ₃ alkylthio, C ₁ -C _3- haloalkylthio, C ₁ -C ₃ alkylsulfinyl, C ₁ -C ₃ haloalkylsulfinyl, C ₁ -C ₃ alkylsulfonyl, C ₁ -C ₃ haloalkyl Sulfhydryl, C ₁ -C ₄ alkylamino, bis(C ₁ -C ₄ alkyl)amine, C ₁ -C ₄ alkylcarbonyl, C ₁ -C ₄ alkylcarbonyloxy, C ₁ - C ₄ alkoxycarbonyl, C ₁ -C ₄ alkylcarbonylamino and phenyl; R ⁴ each independently is halogen, cyano, nitro, hydroxy, C ₁ -C ₈ alkoxy, C ₁ -C ₈ -haloalkoxy, C ₁ -C ₈ alkylthio, C ₁ -C ₈ haloalkylthio, C ₁ -C ₈ alkylsulfinyl, C ₁ -C ₈ haloalkylsulfinyl, C ₁ -C ₈ alkylsulfonyl, C ₁ -C ₈ haloalkylsulfonyl, C ₁ -C ₈ alkylcarbonyl, C ₁ -C ₈ alkoxycarbonyl, aryl or from one to five R ³ a substituted aryl group, or a heterocyclic group or a heterocyclic group substituted by one to five R ³ ; Q ² is a moiety having the formula (II) Wherein R ⁷ and R ⁶ are each independently hydrogen, cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy-C ₁ -C ₄ -alkyl , C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ Alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl; R ^{5 is} independently hydrogen, hydroxy, amine, NC ₁ -C ₆ alkylamino, N,N-di-(C ₁ -C ₆ alkyl)amino, C ₁ -C ₆ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, substituted by one to five substituents R ⁹ C ₁ -C ₆ alkyl group, by one to five substituents R ⁹ is a substituted C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkynyl group substituted by one to five substituents R ^9, substituted by one to five a R ² -substituted C ₂ -C ₆ alkenyl group, an aryl group or an aryl group substituted with one to five substituents R ¹⁰ , a heteroaryl group or a heteroaryl group substituted by one to five substituents R ¹⁰ , each of R ⁹ Independently cyano, nitro, amine, hydroxy, halogen, NC ₁ -C ₆ alkylamino, N,N-di-(C ₁ -C ₆ alkyl)amine, C ₁ -C ₆ alkoxy group, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl acyl, aryl, or by one to five independent Selected from cyano, nitro, hydroxy, halo, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy or C ₁ -C ₆ haloalkoxy substituent group Substituted aryl or heteroaryl or from one to five independently selected from cyano, nitro, hydroxy, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ a heteroaryl group substituted with a substituent of an alkoxy group or a C ₁ -C ₆ haloalkoxy group; each of R ^{10 is} independently a cyano group, a nitro group, an amine group, a hydroxyl group, a halogen, a C ₁ -C ₆ alkyl group, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy-C ₁ -C ₄ -alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl, C ₂ -C ₆ haloalkynyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ - C ₄ alkoxy-C ₁ -C ₄ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, N- C ₁ -C ₆ alkylamino, N , N -di- (C ₁ -C ₆ alkyl) amino, N, N - two - (C ₁ -C ₆ alkyl) aminocarbonyl, N, N- two - (C ₁ -C ₆ alkyl) acyl sulfo group , C ₁ -C ₆ alkyl carbonyl a C ₁ -C ₆ alkylcarbonyloxy group, a C ₁ -C ₆ alkoxycarbonyl group, a C ₁ -C ₆ alkylcarbonylamino group; or an agrochemically acceptable salt or N-oxide thereof.

The compounds of formula (I) may exist in different spatial isomers, optical isomers (Spiegelmer and/or non-Spiegelmer) or tautomeric forms. The present invention includes all such isomers and tautomers, as well as mixtures thereof in various ratios, as well as isotopic forms such as deuterated compounds.

Unless otherwise stated, an alkyl group as a single moiety or as part of another group (eg, alkoxy, alkylcarbonyl or alkoxycarbonyl) may be straight or branched, preferably containing from 1 to 6 More preferably 1 to 4 carbon atoms, most preferably 1 to 3. Examples of the alkyl group include a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, a second butyl group, an isobutyl group, and a tert-butyl group.

Unless otherwise stated, alkenyl and alkynyl as part of a single moiety or another substituent may be straight or branched, and preferably may contain from 2 to 6 carbon atoms, preferably from 2 to 4. More preferably 2 to 3, and where appropriate, an (E) or (Z) configuration is available. Examples include vinyl, allyl, propargyl base.

Halogen means fluorine, chlorine, bromine or iodine.

A haloalkyl group may contain one or more of the same or different halo atoms and includes, for example, trifluoromethyl, chlorodifluoromethyl, 2,2,2-trifluoroethyl or 2,2- Difluoroethyl. The perfluoroalkyl group is an alkyl group which can be completely substituted with a fluorine atom, and includes, for example, a trifluoromethyl group, a pentafluoroethyl group, and a heptafluoroprop-2-yl group.

The haloalkenyl and haloalkynyl groups may contain one or more of the same or different halo atoms and include, for example, 2,2-difluorovinyl, 1,2-dichloro-2-fluorovinyl or 1 chloroprop-2-yn-1-yl.

Unless otherwise stated, a cycloalkyl group may be monocyclic or bicyclic, optionally substituted by one or more C ₁ -C ₆ alkyl groups, and preferably contains from 3 to 8 carbon atoms, more preferably from 3 to 6 carbon atom. Examples of the cycloalkyl group include a cyclopropyl group, a 1-methylcyclopropyl group, a 2-methylcyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group.

Halocycloalkyl groups may contain one or more identical or different halogen atoms and include, for example, 2,2-dichlorocyclopropyl, 2,2-dichloro-1-methylcyclopropyl, and 2-Chloro-4-fluorocyclohexyl.

The aryl group includes a phenyl group, a naphthyl group, an onion group, an anthracenyl group, a phenanthryl group and a biphenyl group, preferably a phenyl group.

Heteroaryl means a monocyclic, bicyclic or tricyclic aromatic hydrocarbon containing from 3 to 14, preferably from 5 to 10, more preferably from 6 to 8 ring atoms, including from 1 to 6, preferably from 1 to Four heteroatoms independently selected from the group consisting of nitrogen, oxygen and sulfur. Examples include furyl, thienyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, Azolyl, different Azolyl, Diazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridyl, anthracene Base, pyrimidinyl, pyridyl Base, three Base, four Base, fluorenyl, benzothienyl, benzofuranyl, benzimidazolyl, benzothiadiazolyl, oxazolyl, benzotriazolyl, benzothiazolyl, benzo Azyl, quinolinyl, isoquinolinyl, anthracene Base Lolinyl, quinazolinyl, Andolinyl and naphthyridinyl.

Heterocyclyl (as used herein) includes heteroaryl, and may also be a saturated or partially unsaturated cyclic hydrocarbon containing from 3 to 10 ring atoms, up to four of which are selected from the group consisting of nitrogen, oxygen and sulfur. A heteroatom, and optionally substituted with one or more groups independently selected from halo, nitro, cyano, alkyl, alkoxy. Examples of non-aromatic heterocyclic groups are oxiranyl, azetidinyl, tetrahydrofuranyl, thio Base, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, cyclobutenyl, di , dihydropyranyl, tetrahydropyranyl, piperidinyl, pyrazolinyl, pyrazolyl, di Alkyl, morpholinyl, dithiaalkyl, thiomorpholinyl, piperidine a base, a nitrogen sulfhydryl group, an oxazepinyl group, a thiazepinyl group, a thiazolinyl group, and a diazapyl group.

Preferred values of A ¹ , A ² , A ³ , A ⁴ , R ¹ , R ² , R ³ , G ¹ , X, Q ¹ , Q ² , R ⁵ , R ⁶ , R ⁷ are, in any combination, As described below.

A ^{1 is} preferably CX.

A ^{2 is} preferably CX.

A ^{3 is} preferably CX.

A ^{4 is} preferably CX.

X is preferably hydrogen, halogen, cyano, methyl, trifluoromethyl or methoxy. More preferably, X is hydrogen, fluoro, chloro, cyano, trifluoromethyl or methoxy. Even more preferably, X is hydrogen, fluoro, cyano or methoxy. Best of all, X is hydrogen, a fluorine group or a cyano group.

Preferably, A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and methoxy, and A ² and A ^{3 is} preferably CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and methoxy, and more preferably, each X is independent. It is selected from the group consisting of hydrogen, fluorine, cyano and methoxy. Even more preferably, A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy. Most preferably, A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH or A ¹ , A ² and A ³ are CH and A ⁴ is CH, C-OCH ₃ or CF. Most preferably, A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH. Further preferably, A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF.

G ^{1 is} preferably oxygen.

R ^{1 is} preferably hydrogen, methyl, ethyl or ethyl fluorenyl. More preferably, R ¹ is hydrogen, methyl or ethyl. Most preferably, R ¹ is hydrogen.

R ^{2 is} preferably hydrogen, methyl, trifluoromethyl or halogen. More preferably, R ² is hydrogen, trifluoromethyl or halogen. Even more preferably, R ² is hydrogen or halogen. Most preferably, R ² is hydrogen.

Q ^{1 is} preferably an aryl or heteroaryl group; each of which is optionally independently selected from one to five selected from the group consisting of cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, trifluoromethyl, methoxy Substituent substitution of a group, a trifluoromethoxy group, a methylthio group, a sulfinyl group, a methanesulfonyl group, and a phenyl group.

More preferably, Q ¹ is phenyl, pyridyl, furyl, thienyl, pyrazolyl or 1,2,3-thiadiazolyl; each of which is optionally independently selected from one to four selected from the group consisting of cyano and nitrate Substituents of hydroxy, bromo, bromo, chloro, fluoro, methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, sulfinyl, methylsulfonyl and phenyl groups Substituted.

Even more preferably, Q ¹ is phenyl, pyridyl or pyrazolyl; each optionally one to four independently selected from the group consisting of cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, Substituent substitution of ethyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, sulfinyl, methanesulfonyl and phenyl.

Most preferably, Q ¹ is phenyl or pyridyl; each of which is optionally selected from one, two or three independently from cyano, nitro, chloro, fluoro, methyl, ethyl, trifluoromethyl Substituent substitution of a methoxy group and a trifluoromethoxy group.

In another preferred specific example, Q ¹ is C ₁ -C ₈ alkyl or by one to five R ⁴ is a substituted C ₁ -C ₈ alkyl, C ₂ -C ₈ alkenyl group or by one to five R ⁴ substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group, or, C ₃ -C ₁₀ cycloalkyl or substituted by one to five R ⁴ is a substituted C ₂ -C ₈ alkynyl group by one to five R ⁴ C ₃ -C ₁₀ cycloalkyl, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₈ alkoxy, C ₁ -C ₈ haloalkoxy, C ₁ -C ₈ alkylthio, C ₁ -C ₈ haloalkylthio, C ₁ -C ₈ alkylsulfinyl, C ₁ -C ₈ haloalkylsulfinyl, C ₁ -C ₈ alkylsulfonyl , C ₁ -C ₈ haloalkylsulfonyl, C ₁ -C ₈ alkylcarbonyl, C ₁ -C ₈ alkoxycarbonyl, aryl or aryl substituted by one to five R ³ or a heterocyclic ring A group or a heterocyclic group substituted by one to five R ³ , and R ³ has the meaning imparted in the context.

In another particular example, more preferably, Q ¹ is C ₁ -C ₄ alkyl, or substituted by one to five R ⁴ C ₁ -C ₄ alkyl, C ₂ -C ₈ alkenyl group or by one to five R ⁴ substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or substituted by one to five R ⁴ C ₂ -C ₈ alkynyl, C ₃ -C ₆ cycloalkyl, or substituted by one to five R ⁴ C ₃ -C ₆ cycloalkyl, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, C ₁ -C _{a 4} -alkylthio group, a C ₁ -C ₄ haloalkylthio group, a C ₁ or aryl group or an aryl group substituted by one to five R ³ or a heterocyclic group or a heterocyclic group substituted by one to five R ³ And R ³ has the meaning given in the context, or R ^{3 is} preferably H or halogen.

In another even more preferred embodiment, Q ¹ is C ₁ -C ₄ alkyl or C ₁ -C ₄ alkyl, C ₂ -C ₈ alkenyl substituted by one to five R ⁴ or from one to five R ⁴ is a substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or substituted by one to five R ⁴ C ₂ -C ₈ alkynyl, C ₃ -C ₆ cycloalkyl, or by one to five R ^{a 4-} substituted C ₃ -C ₆ cycloalkyl group, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, or aryl a aryl group substituted by one to five R ³ or a heterocyclic group or a heterocyclic group substituted by one to five R ³ ; and R ³ has the meaning given in the context, or R ^{3 is} preferably H Or halogen.

Preferred examples of Q ¹ include (2,6-dichlorophenyl)-methyl, (4-methoxyphenyl)-methyl, (E)-2-isobutoxyvinyl, 1-(4 -Chlorophenyl)-2-methyl-propan-1-yl, 1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazol-4-yl, 1-(4-chlorobenzene Cyclopentyl, 1-(4-fluorophenyl)-5-methyl-1H-pyrazol-4-yl, 1-methyl-1H-benzotriazol-5-yl, 1-methyl 3-tert-butyl-1H-pyrazol-5-yl, 1-methyl-3-trifluoromethyl-4-chloro-1H-pyrazole-5-yl, 1-methylbenzotriazole -5-yl, 1-phenyl-5-propyl-1H-pyrazol-4-yl, 1-phenyl-5-trifluoromethyl-1H-pyrazol-4-yl, 1-phenylethyl , 1-tert-butyl-5-methyl-1H-imidazol-4-yl, 2,3-difluoro-phenyl, 2,4-difluoro-phenyl, 2,4,6-tri Methylphenyl, 2,4-dichlorophenyl, 2,6-dichloro-phenyl, 2,1,3-benzo Diazol-5-yl, 2,2,3,3,4,4,4-heptafluorobutane, 2,2,3,3-tetrafluoro-1-methyl-cyclobutane, 2 ,3-difluoro-phenyl, 2,4,6-trifluoro-phenyl, 2,4-difluoro-phenyl, 2,4-dimethyl-1,1,3-trioxy -2,3-dihydro-1H-1 λ ^* 6 ^* -benzo[d]isothiazol-5-yl, 2,5-dimethyl-furan-3-yl, 2,5-dimethylpyridyl Zyrid-3-yl, 2,6-dichloro-4-pyridyl, 2-chloro-3-pyridyl, 2-chloro-4-cyano-phenyl, 2-chloro-4-methylsulfonate Mercapto-phenyl, 2-chloro-6-methoxy-4-pyridyl, 2-chloro-phenyl, 2-chlorothiazol-5-yl, 2-ethylhexyl, 2-fluoro-4 -trifluoromethyl-phenyl, 2-fluoro-5-chloro-phenyl, 2-fluoro-5-trifluoromethyl-phenyl, 2-fluoro-phenyl, 2-isopropylsulfonate Phenylphenyl, 2-methoxy-phenyl, 2-methyl-4-cyano-phenyl, 2-methyl-4-fluoro-phenyl, 2-methyl-4-nitro-benzene Base, 2-methylethyl, 2-methyl-phenyl, 2-methylsulfonylethyl, 2-phenylthiazol-4-yl, 2-phenyl-thiazol-4-yl, 2-pyridyl, 2-thienylmethyl, 2-trifluoromethoxy-phenyl, 2-trifluoromethyl-4-fluorophenyl, 2-trifluoromethyl-phenyl, 3-(2-chloro-phenyl )-5-methyl-iso Zin-4-yl, 3,5-difluorophenyl, 3,5-dimethyl-iso Zin-4-yl, 3-chloro-2,2-dimethyl-propane, 3-chloro-4-(isopropylsulfonyl)-thiophen-2-yl, 3-chloro-4- Isopropyl sulfonyl-thiophen-2-yl, 3-chloro-5-trifluoromethyl-2-pyridyl, 3-chloro-benzo[b]thiophen-2-yl, 3-chlorothiophene- 2-yl, 3-chloro-thiophen-2-yl, 3-pyridyl, 3-pyridyl-N-oxide, 3-trifluoromethyl-4-fluoro-phenyl, 3-trifluorotoluene , 4-(chloromethyl)phenyl, 4-cyano-2-methyl-phenyl, 4-cyano-phenyl, 4-fluoro-2-chloro-phenyl, 4-fluorobenzyl , 4-fluoro-phenyl, 4-methyl-[1,2,3]thiadiazole, 4-methyl-[1,2,3]thiadiazolyl, 4-methyl-phenyl, 4-methanesulfonyl phenyl, 4-nitro-2-chloro-phenyl, 4-nitro-phenyl, 4-pyridyl, 4-pyridine-N-oxide, 4-tert-butylbenzene , 4-trifluoromethoxy-phenyl, 4-trifluoromethyl-phenyl, 5-chloro-1-methyl-1H-pyrazol-4-yl, 5-chloro-3-pyridine , 5-methyl-2-phenyl-2H-[1,2,3]triazol-4-yl, 5-methyl-2-trifluoromethyl-furan-3-yl, 5-methyl -3-(2-chloro-5-fluoro-phenyl)-iso Zin-4-yl, 5-methyl-3-phenyl-iso Zin-4-yl, 5-methyl Zyrid-3-yl, 5-methyl-iso Zyridin-3-yl, 6-(trifluoromethyl)naphthalen-3-yl, 6-chloro-3-pyridyl, 6-chloropyridin-3-yl, 6-trifluoromethyl-3-pyridyl , benzo[b]thiophen-2-yl, benzo[c]thiophen-1-yl, benzyl, 3-butenyl, butane, cyclobutyl, cyclohexyl, cyclopropyl, vinyl, Fluoromethyl, furyl, iso Zyrid-5-yl, methoxymethyl, methylpropion-3-yl, naphthalen-1-yl, phenyl, phenethyl, quinolin-2-yl, quin Andros-2-yl, tert-butyl, thiophen-2-yl, thiophen-2-yl and trichloromethyl.

Another preferred example of Q ¹ includes (2,6-dichlorophenyl)-methyl, (4-methoxyphenyl)-methyl, (E)-2-isobutoxyvinyl, 1-( 4-chlorophenyl)-2-methyl-propan-1-yl, 1-(4-chlorophenyl)cyclopentyl, 1-phenylethyl, 2,2,3,3,4,4,4 -heptafluorobutane, 2,2,3,3-tetrafluoro-1-methyl-cyclobutane, 2-ethylhexyl, 2-methylethyl, 3-chloro-2,2- Dimethyl-propane, 3-trifluoromethylbenzyl, 4-fluorobenzyl, 3-butenyl, butane, cyclobutyl, cyclohexyl, cyclopropyl, vinyl, fluoromethyl, Methoxymethyl, methylpropionic acid-3-yl, phenethyl, tert-butyl and trichloromethyl.

Another preferred example of Q ¹ includes 1-(4-chlorophenyl)-5-trifluoromethyl-1H-pyrazol-4-yl, 1-(4-fluorophenyl)-5-methyl-1H -pyrazol-4-yl, 1-methyl-1H-benzotriazol-5-yl, 1-methyl-3-t-butyl-1H-pyrazole-5-yl, 1-methyl- 3-trifluoromethyl-4-chloro-1H-pyrazol-5-yl, 1-methylbenzotriazol-5-yl, 1-phenyl-5-propyl-1H-pyrazole-4 -yl, 1-phenyl-5-trifluoromethyl-1H-pyrazol-4-yl, 1-tert-butyl-5-methyl-1H-imidazol-4-yl, 2,4,6- Trimethylphenyl, 2,4-dichlorophenyl, 2,6-dichloro-phenyl, 2,1,3-benzo Azul-5-yl, 2,3-difluoro-phenyl, 2,3-difluoro-phenyl, 2,4,6-trifluoro-phenyl, 2,4-difluoro- Phenyl, 2,4-difluoro-phenyl, 2,4-dimethyl-1,1,3-trioxo-2,3-dihydro-1H-1 λ ^* 6 ^* -benzo[d Isothiazol-5-yl, 2,5-dimethyl-furan-3-yl, 2,5-dipyrazol-3-yl, 2,6-dichloro-4-pyridyl, 2- Chloro-3-pyridyl, 2-chloro-4-cyano-phenyl, 2-chloro-4-methylsulfonyl-phenyl, 2-chloro-6-methoxy-4-pyridine , 2-chloro-phenyl, 2-chlorothiazol-5-yl, 2-fluoro-4-trifluoromethyl-phenyl, 2-fluoro-5-chloro-phenyl, 2-fluoro 5--5-trifluoromethyl-phenyl, 2-fluoro-phenyl, 2-isopropylsulfonylphenyl, 2-methoxy-phenyl, 2-methyl-4-cyano-phenyl , 2-methyl-4-fluoro-phenyl, 2-methyl-4-nitro-phenyl, 2-methyl-phenyl, 2-methylsulfonylethyl, 2-phenylthiazole-4- , 2-phenyl-thiazol-4-yl, 2-pyridyl, 2-thienylmethyl, 2-trifluoromethoxy-phenyl, 2-trifluoromethyl-4-fluorophenyl, 2- Trifluoromethyl-phenyl, 3-(2-chloro-phenyl)-5-methyl-iso Zin-4-yl, 3,5-difluorophenyl, 3,5-dimethyl-iso Zin-4-yl, 3-chloro-4-(isopropylsulfonyl)-thiophen-2-yl, 3-chloro-4-isopropylsulfonyl-thiophen-2-yl, 3-chloro -5-trifluoromethyl-2-pyridyl, 3-chloro-benzo[b]thiophen-2-yl, 3-chlorothiophen-2-yl, 3-chloro-thiophen-2-yl, 3 -pyridyl, 3-pyridyl-N-oxide, 3-trifluoromethyl-4-fluoro-phenyl, 4-(chloromethyl)phenyl, 4-cyano-2-methyl-benzene Base, 4-cyano-phenyl, 4-fluoro-2-chloro-phenyl, 4-fluoro-phenyl, 4-methyl-[1,2,3]thiadiazole, 4-methyl -[1,2,3]thiadiazolyl, 4-methyl-phenyl, 4-methylsulfonylphenyl, 4-nitro-2-chloro-phenyl, 4-nitro-benzene , 4-pyridyl, 4-pyridine-N-oxide, 4-tert-butylphenyl, 4-trifluoromethoxy-phenyl, 4-trifluoromethyl-phenyl, 5-chloro 1-methyl-1H-pyrazol-4-yl, 5-chloro-3-pyridyl, 5-methyl-2-phenyl-2H-[1,2,3]triazol-4-yl , 5-methyl-2-trifluoromethyl-furan-3-yl, 5-methyl-3-(2-chloro-5-fluorophenyl)-iso Zin-4-yl, 5-methyl-3-phenyl-iso Zin-4-yl, 5-methyliso Zyrom-3-yl, 5-methyliso Zyridin-3-yl, 6-(trifluoromethyl)naphthalen-3-yl, 6-chloro-3-pyridyl, 6-chloropyridin-3-yl, 6-trifluoromethyl-3-pyridyl Benzo[b]thiophen-2-yl, benzo[c]thiophen-1-yl, benzyl, furyl, iso Zyrid-5-yl, naphthalen-1-yl, phenyl, quinolin-2-yl, quin Andros-2-yl, thiophen-2-yl and thiophen-2-yl.

Another preferred example of Q ¹ includes phenyl, 5-bromofuran-2-yl, 2-methoxyphenyl, 2-bromophenyl, 2-methylphenyl, 5-bromopyridin-3-yl, 3-methylpyridin-2-yl, 2-chloro-4-fluorophenyl, 4-methyl-1,2,3-thiadiazol-5-yl, 3-chloro-2-fluorophenyl 4-nitrophenyl, 5-chloro-2-fluorophenyl, 3-chloro-2-methylphenyl, 1,2,3-thiadiazol-4-yl, 2-chloro- 4-nitrophenyl, thiophen-2-yl, 2-chloro-5-nitrophenyl, 2-(trifluoromethoxy)phenyl, 2-chlorophenyl, 4-(trifluoromethoxy) Phenyl, 3-chlorophenyl, 2-(trifluoromethyl)phenyl, 2-chloropyridin-3-yl, 4-(trifluoromethyl)phenyl, 2-chloropyridin-4-yl, 2 -methyl-4-cyanophenyl, 6-chloropyridin-3-yl, 2,4,6-trifluorophenyl, 5-chlorothiophen-2-yl, 2,6-difluorophenyl, 3-chloro -5-(trifluoromethyl)pyridin-2-yl, 2,6-difluoro-4-cyanophenyl, 4-cyano-2-fluorophenyl, 2-chloro-6-fluorophenyl 4-cyanophenyl, 2-methyl-3-nitrophenyl, 2-methyl-4-nitrophenyl, 2,5-dichlorophenyl, 3-methyl-4-nitrobenzene Base, 2,3-difluorophenyl, 2-chloro-4-cyanophenyl, 1,3-dimethyl-1H-pyrazol-5-yl, 2-fluoro-4-cyanobenzene Base, 2-fluorophenyl 4-methylthienyl, 4-fluorophenyl, 1-methyl-3-(trifluoromethyl)pyrazol-4-yl, 2-fluoropyridin-3-yl, 4-pyridyl, 2-fluoro 3-(trifluoromethyl)phenyl, 1,3-dimethylpyrazol-4-yl, 2-fluoro-5-(trifluoromethyl)-phenyl, 4-methylphenyl , 4-fluoro-3-(trifluoromethyl)phenyl, 4-fluoro-2-methylphenyl, furan-2-yl and 2,4-difluorophenyl, cyclopropyl, benzyl .

In another preferred embodiment, Q ² is a moiety of formula (II) wherein the substituents R ⁵ , R ⁶ and R ⁷ have the following meanings: R ⁷ and R ^{6 are} independently hydrogen, cyano, halogen, C _1- C ₆ alkyl, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkylthio, C ₁ -C ₆ perfluoroalkylsulfinyl or C ₁ -C ₆ -perfluoro Alkylsulfonyl, preferably independently C ₁ -C ₄ perfluoroalkyl, C ₁ -C ₄ perfluoroalkylthio, C ₁ -C ₄ -perfluoroalkylsulfinyl or C ₁ - C ₄ -perfluoroalkylsulfonyl, even more preferably independently C ₁ -C ₄ -perfluoroalkyl, C ₁ -C ₄ -perfluoroalkylthio or C ₁ -C ₄ -perfluoroalkyl The sulfonyl group is preferably an independently trifluoromethyl or perfluoroethyl or trifluoromethylthio group or a perfluoroethylthio group or a trifluoromethanesulfonyl group or a perfluoroethanesulfonyl group.

More preferably, R ⁷ and R ⁶ are independently cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ -perfluoroalkyl, preferably independently C ₁ -C ₆ -perfluoro Alkyl groups, even more preferably independently, are trifluoromethyl or perfluoroethyl.

Even more preferably, R ⁷ and R ^{6 are} independently halogen, C ₁ -C ₆ perfluoroalkyl.

Most preferably, R ⁶ is a trifluoromethyl group.

Most preferably, R ⁷ is a perfluoroethyl group.

Preferably, R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, phenyl or from one to five It may be the same or different substituents R ¹⁰ phenyl, pyridyl, or may be by one to five identical or different substituents R ¹⁰ pyridyl.

More preferably, R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl, and even more preferably, R ⁵ is C ₁ -C ₆ alkyl, preferably C ₁ - C ₄ alkyl; in another preferred embodiment, Q ² is a part of formula (II), wherein the substituents R ⁵ , R ⁶ and R ⁷ have the following meanings: R ⁷ and R ^{6 are} independently cyano, Halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkylthio, C ₁ -C ₆ perfluoroalkylsulfinyl or C ₁ -C ₆ a perfluoroalkylsulfonyl group; and R ⁵ is a C ₁ -C ₆ haloalkyl group or a C ₁ -C ₆ alkyl group; even more preferably, R ⁵ is a C ₁ -C ₆ alkyl group, preferably C ₁ -C ₄ alkyl; in a preferred embodiment, Q ² is 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl

Preferred examples (E1) of the substituents in the compound of the formula (I) have the following meanings: R ¹ is hydrogen, methyl, ethyl or ethyl fluorenyl; R ² is hydrogen, methyl, trifluoromethyl or halogen ; G ¹ is oxygen; Q ¹ is aryl or heteroaryl; each optionally from one to five independently selected from cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, trifluoromethyl Substituted with a substituent of a methoxy group, a methoxy group, a trifluoromethoxy group, a methylthio group, a sulfinyl group, a methylsulfonyl group, and a phenyl group; Q ² is a moiety having the formula (II) Wherein R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, phenyl or from one to five may be the same or phase a heterophenyl substituted with a R ¹⁰ substituent, a pyridyl group or a pyridyl group substituted with one to five R ¹⁰ substituents which may be the same or different; R ⁷ and R ^{6 are} independently hydrogen, cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkylthio, C ₁ -C ₆ perfluoroalkylsulfinyl or C ₁ -C ₆ -perfluoroalkane Sulfosyl, preferably independently C ₁ -C ₄ perfluoroalkyl, C ₁ -C ₄ perfluoroalkylthio, C ₁ -C ₄ -perfluoroalkylsulfinyl or C ₁ -C ₄ -Perfluoroalkylsulfonyl, even more preferably independently C ₁ -C ₄ -perfluoroalkyl, C ₁ -C ₄ -perfluoroalkylthio or C ₁ -C ₄ -perfluoroalkylsulfonate Mercapto group; preferred embodiment (E2) The substituent in the compound of formula (I) has the following meaning: R ¹ is hydrogen, methyl or ethyl; R ² is hydrogen, trifluoromethyl or halogen; Q ¹ is Phenyl, pyridyl, furyl, thienyl, pyrazolyl or 1,2,3-thiadiazolyl; each optionally from one to four independently selected from cyano, nitro, hydroxy, bromo, chloro Base, fluorine base Methyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, methyl sulfinyl group, and a phenyl methanesulfonamide acyl substituents; Q ² having a formula (II), section Wherein R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl; R ⁷ and R ^{6 are} independently cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ - Perfluoroalkyl; preferred embodiment (E3) The substituent in the compound of formula (I) has the following meaning: R ¹ is hydrogen, methyl or ethyl; R ² is hydrogen or halogen; Q ¹ is phenyl, Pyridyl or pyrazolyl; each optionally from one to four independently selected from the group consisting of cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, ethyl, trifluoromethyl, methoxy, Substituted by a substituent of a trifluoromethoxy group, a methylthio group, a sulfinyl group, a methanesulfonyl group, and a phenyl group; Q ² is a moiety having the formula (II) Wherein R ^{5 is} preferably C ₁ -C ₄ alkyl; R ⁷ and R ^{6 are} independently C ₁ -C ₆ -perfluoroalkyl; preferred embodiments (E4) are substituents in the compound of formula (I) Has the following meaning: R ¹ is hydrogen; R ² is hydrogen Q ¹ is phenyl or pyridyl; each of which is optionally independently selected from cyano, nitro, chloro, fluoro, methyl, ethyl, trifluoro Methyl, methoxy and trifluoromethoxy; Q ² is one, two or three of 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl Substituted for substitution.

Preferred examples (E5) of the substituents in the compound of the formula (I) have the following meanings: R ¹ is hydrogen, methyl, ethyl or ethyl fluorenyl; R ² is hydrogen, methyl, trifluoromethyl or halogen ; G ¹ is oxygen; Q ¹ is a C ₁ -C ₄ alkyl, or substituted by one to five R ⁴ C ₁ -C ₄ alkyl, C ₂ -C ₈ alkenyl or substituted with one to five R ⁴ is C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or substituted by one to five R ⁴ C ₂ -C ₈ alkynyl, C ₃ -C ₆ cycloalkyl, or substituted by one to five R ⁴ C _3- C ₆ cycloalkyl, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, or aryl or from one to a five R ³ -substituted aryl group, or a heterocyclic group or a heterocyclic group substituted by one to five R ³ ; and R ³ has the meaning given in the context, or preferably R ³ is H or halogen; Q ² is a part with formula (II) Wherein R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, phenyl or from one to five may be the same or phase a heterophenyl substituted with a R ¹⁰ substituent, a pyridyl group or a pyridyl group substituted with one to five R ¹⁰ substituents which may be the same or different; R ⁷ and R ^{6 are} independently hydrogen, cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkylthio, C ₁ -C ₆ perfluoroalkylsulfinyl or C ₁ -C ₆ -perfluoroalkane Sulfosyl, preferably independently C ₁ -C ₄ perfluoroalkyl, C ₁ -C ₄ perfluoroalkylthio, C ₁ -C ₄ -perfluoroalkylsulfinyl or C ₁ -C ₄ -Perfluoroalkylsulfonyl, even more preferably independently C ₁ -C ₄ -perfluoroalkyl, C ₁ -C ₄ -perfluoroalkylthio or C ₁ -C ₄ -perfluoroalkylsulfonate Mercapto group; preferred embodiment (E6) The substituent in the compound of formula (I) has the following meaning: R ¹ is hydrogen, methyl or ethyl; R ² is hydrogen, trifluoromethyl or halogen; Q ¹ is C ₁ -C ₄ alkyl, or substituted by one to five ^{R. 4} C ₁ -C ₄ alkyl, C ₂ -C ₈ alkenyl or substituted by one to five R of ⁴ C ₂ -C ₈ alkenyl, C _2- C ₈ alkynyl or C ₂ -C substituted by one to five R ⁴ ₈ alkynyl, C ₃ -C ₆ cycloalkyl, or by one to five R ⁴ is a substituted C ₃ -C ₆ cycloalkyl, and each R ⁴ is independently halo, cyano, nitro, hydroxy, C ₁ - a C ₄ alkoxy group, a C ₁ -C ₄ haloalkoxy group, or an aryl group or an aryl group substituted with one to five R ³ or a heterocyclic group or a heterocyclic group substituted with one to five R ³ ; R ³ has the meaning assigned in the context, or R ^{3 is} preferably H or halogen; Q ² is a moiety having formula (II) Wherein R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl; R ⁷ and R ^{6 are} independently cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ - Perfluoroalkyl; preferred embodiment (E7) The substituent in the compound of formula (I) has the following meaning: R ¹ is hydrogen, methyl or ethyl; R ² is hydrogen or halogen; Q ¹ is C ₁ - C ₄ alkyl or C ₁ -C ₄ alkyl substituted by one to five R ⁴ , C ₂ -C ₈ alkenyl or C ₂ -C ₈ alkenyl, C ₂ -C substituted by one to five R ⁴ ₈ alkynyl or C ₂ -C ₈ alkynyl substituted by one to five R ⁴ , C ₃ -C ₆ cycloalkyl or C ₃ -C ₆ cycloalkyl substituted by one to five R ⁴ , and each R ⁴ Independently halogen, cyano, nitro, hydroxy, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy, or aryl or aryl substituted by one to five R ³ , or hetero a cyclic group or a heterocyclic group substituted by one to five R ³ ; and R ³ has the meaning given in the context, or R ^{3 is} preferably H or halogen; Q ² is a moiety having the formula (II) Wherein R ^{5 is} preferably C ₁ -C ₄ alkyl; R ⁷ and R ^{6 are} independently C ₁ -C ₆ -perfluoroalkyl; preferred substituent (E8) is a substituent in the compound of formula (I) have the following meanings: R ¹ is hydrogen; R ² is hydrogen Q ¹ is C ₁ -C ₄ alkyl, or substituted by one to five R _⁴ C ₁ -C ⁴ alkyl, C ₂ -C ₈ alkenyl group or by one to five R ⁴ is a substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or substituted by one to five R ⁴ C ₂ -C ₈ alkynyl, C ₃ -C ₆ cycloalkyl, or by one to Five R ⁴ -substituted C ₃ -C ₆ cycloalkyl groups, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₄ alkoxy, C ₁ -C ₄ haloalkoxy Or an aryl group or an aryl group substituted by one to five R ³ or a heterocyclic group or a heterocyclic group substituted by one to five R ³ ; and R ³ has the meaning given in the context, or R ³ is more Preferably, it is H or halogen; Q ² is 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl.

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E1)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E1)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E1)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E1)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E1)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E1) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E2)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A1 and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E2)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E2)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E2)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E2)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E2) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E3)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; Al and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E3)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E3)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E3)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E3)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E3) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E4)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A1 and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E4)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E4)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ² are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E4)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E4)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the specific example (E4) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E5)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E5)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E5)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E5)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E5)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E5) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E6)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E6)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E6)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E6)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E6)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E6) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E7)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E7)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E7)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E7)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E7)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the specific example (E7) significance

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Oxygen, and other substituents have the meaning as in the specific example (E8)

A preferred embodiment is a compound of formula (I) wherein A ² and A ³ are both CH; A ¹ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl And methoxy, and more preferably each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and the other substituents have the meaning as in the specific example (E8)

A preferred embodiment is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, fluoro, cyano and methoxy, and other substituents Has the meaning as in the specific example (E8)

A preferred embodiment is a compound of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF, and A ² , A ³ and A ⁴ are CH, or A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have the meaning as in the specific example (E8)

Preferred specific examples are compounds of formula (I) wherein A ¹ is CH, C-CN, C-Cl or CF; A ² , A ³ and A ⁴ are CH methoxy groups, and the other substituents are as specific The meaning of the instance (E8)

Preferred specific examples are compounds of formula (I) wherein A ¹ , A ² and A ³ are CH, and A ⁴ is CH, C-OCH ₃ or CF, and the other substituents have as in specific example (E8) significance

A preferred embodiment (Ea) is a compound of formula (I) wherein A ¹ is C-CN and A ² , A ³ and A ⁴ are CH.

A preferred embodiment (Eb) is a compound of formula (I) wherein A ⁴ is CF and A ¹ , A ² and A ³ are CH.

A preferred embodiment (Ec) is a compound of formula (I) wherein A ⁴ is C-OMe and A ¹ , A ² and A ³ are CH.

A preferred embodiment (Ed) is a compound of formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CH.

A preferred embodiment (Ee) is a compound of formula (I) wherein A ¹ is C-Cl and A ² , A ³ and A ⁴ are CH.

A preferred embodiment (Ef) is a compound of formula (I) wherein A ¹ is CF and A ² , A ³ and A ⁴ are CH.

A preferred embodiment (Eg) is a compound of formula (I) wherein A ¹ is C-CF ₃ and A ² , A ³ and A ⁴ are CH.

A preferred embodiment (Eh) is a compound of formula (I) wherein A ⁴ is N and A ¹ , A ² and A ³ are CH.

A preferred embodiment (Ei) is a compound of formula (I) wherein A ⁴ is N, A ¹ is CN, and A ² and A ³ are CH.

A preferred embodiment (Ej) is a compound of formula (I) wherein A ⁴ is N, A ¹ is F, and A ² and A ³ are CH.

A preferred embodiment (Ea1) is a compound of the formula (I) wherein A ¹ is C-CN, and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E1) The meaning.

A preferred embodiment (Eb1) is a compound of formula (I) wherein A ⁴ is CF, and A ¹ , A ² and A ³ are CH, and the other substituents have the meaning as given in the specific example (E1) .

A preferred embodiment (Ec1) is a compound of formula (I) wherein A ⁴ is C-OMe, A ¹ , A ² and A ³ are CH, and the other substituents are as given in specific example (E1) significance.

A preferred embodiment (Ed1) is a compound of the formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CH, and the other substituents have the meanings as given in the specific example (E1).

A preferred embodiment (Ee1) is a compound of the formula (I) wherein A ¹ is C-Cl, A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E1) significance.

A preferred embodiment (Ef1) is a compound of formula (I) wherein A ¹ is CF, and A ² , A ³ and A ⁴ are CH, and the other substituents have the meaning as given in the specific example (E1) .

A preferred embodiment (Eg1) is a compound of the formula (I) wherein A ¹ is C-CF ₃ and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those exemplified in the specific example (E1) With meaning.

A preferred embodiment (Eh1) is a compound of the formula (I) wherein A ⁴ is N, A ¹ , A ² and A ³ are CH, and the other substituents have the meanings as given in the specific example (E1).

A preferred embodiment (Ei1) is a compound of the formula (I) wherein A ⁴ is N, A ¹ is CN, A ² and A ³ are CH, and the other substituents are as given in the specific example (E1) significance.

A preferred embodiment (Ej1) is a compound of formula (I) wherein A ⁴ is N, A ¹ is F, A ² and A ³ are CH, and the other substituents are as given in specific example (E1) significance.

A preferred embodiment (Ea2) is a compound of formula (I) wherein A ¹ is C-CN, and A ² , A ³ and A ⁴ are CH, and the other substituents are as given in specific example (E2) The meaning.

A preferred embodiment (Eb2) is a compound of formula (I) wherein A ⁴ is CF, and A ¹ , A ² and A ³ are CH, and the other substituents have the meaning as given in the specific example (E2) .

A preferred embodiment (Ec2) is a compound of formula (I) wherein A ⁴ is C-OMe, A ¹ , A ² and A ³ are CH, and the other substituents are as given in specific example (E2) significance.

A preferred embodiment (Ed2) is a compound of the formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CH, and the other substituents have the meanings as given in the specific example (E2).

A preferred embodiment (Ee2) is a compound of formula (I) wherein A ¹ is C-Cl, A ² , A ³ and A ⁴ are CH, and the other substituents are as given in specific example (E2) significance.

A preferred embodiment (Ef2) is a compound of the formula (If) wherein A ¹ is CF, and A ² , A ³ and A ⁴ are CH, and the other substituents have the meaning as given in the specific example (E2) .

A preferred embodiment (Eg2) is a compound of formula (I) wherein A ¹ is C-CF ₃ and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E2) With meaning.

A preferred embodiment (Eh2) is a compound of formula (I) wherein A ⁴ is N, A ¹ , A ² and A ³ are CH, and the other substituents have the meanings as given in the specific example (E2).

A preferred embodiment (Ei2) is a compound of formula (I) wherein A ⁴ is N, A ¹ is CN, A ² and A ³ are CH, and the other substituents are as given in specific example (E2) significance.

A preferred embodiment (Ej2) is a compound of formula (I) wherein A ⁴ is N, A ¹ is F, A ² and A ³ are CH, and the other substituents are as given in specific example (E2) significance.

A preferred embodiment (Ea3) is a compound of formula (I) wherein A ¹ is C-CN, and A ² , A ³ and A ⁴ are CH, and the other substituents are as given in the specific example (E3) The meaning.

A preferred embodiment (Eb3) is a compound of formula (I) wherein A ⁴ is CF, and A ¹ , A ² and A ³ are CH, and the other substituents have the meaning as given in the specific example (E3) .

A preferred embodiment (Ec3) is a compound of the formula (I) wherein A ⁴ is C-OMe, A ¹ , A ² and A ³ are CH, and the other substituents have the same as those given in the specific example (E3) significance.

A preferred embodiment (Ed33) is a compound of the formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CH, and the other substituents have the meanings as given in the specific example (E3).

A preferred embodiment (Ee3) is a compound of the formula (I) wherein A ¹ is C-Cl, A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E3) significance.

A preferred embodiment (Ef3) is a compound of formula (I) wherein A ¹ is CF, and A ² , A ³ and A ⁴ are CH, and the other substituents have the meaning as given in the specific example (E3) .

A preferred embodiment (Eg3) is a compound of formula (I) wherein A ¹ is C-CF ₃ and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E3) With meaning.

A preferred embodiment (Eh3) is a compound of the formula (I) wherein A ⁴ is N, A ¹ , A ² and A ³ are CH, and the other substituents have the meanings as given in the specific example (E3).

A preferred embodiment (Ei3) is a compound of formula (I) wherein A ⁴ is N, A ¹ is CN, A ² and A ³ are CH, and the other substituents are as given in specific example (E3) significance.

A preferred embodiment (Ej3) is a compound of formula (I) wherein A ⁴ is N, A ¹ is F, A ² and A ³ are CH, and the other substituents are as given in specific example (E3) significance.

A preferred embodiment (Ea4) is a compound of formula (I) wherein A ¹ is C-CN, and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E4) The meaning.

A preferred embodiment (Eb4) is a compound of formula (I) wherein A ⁴ is CF, and A ¹ , A ² and A ³ are CH, and the other substituents have the meaning as given in the specific example (E4) .

A preferred embodiment (Ec4) is a compound of the formula (I) wherein A ⁴ is C-OMe, A ¹ , A ² and A ³ are CH, and the other substituents have the same as those given in the specific example (E4) significance.

A preferred embodiment (Ed4) is a compound of the formula (I) wherein A ¹ , A ² , A ³ and A ⁴ are CH, and the other substituents have the meanings as given in the specific example (E4).

A preferred embodiment (Ee4) is a compound of formula (I) wherein A ¹ is C-Cl, A ² , A ³ and A ⁴ are CH, and the other substituents are as given in specific example (E4) significance.

A preferred embodiment (Ef4) is a compound of formula (I) wherein A ¹ is CF, and A ² , A ³ and A ⁴ are CH, and the other substituents have the meaning as given in the specific example (E4) .

A preferred embodiment (Eg4) is a compound of formula (I) wherein A ¹ is C-CF ₃ and A ² , A ³ and A ⁴ are CH, and the other substituents have the same as those given in the specific example (E4) With meaning.

A preferred embodiment (Eh4) is a compound of formula (I) wherein A ⁴ is N, A ¹ , A ² and A ³ are CH, and the other substituents have the meanings as given in the specific example (E4).

A preferred embodiment (Ei4) is a compound of formula (I) wherein A ⁴ is N, A ¹ is CN, A ² and A ³ are CH, and the other substituents are as given in specific example (E4) significance.

A preferred embodiment (Ej4) is a compound of formula (I) wherein A ⁴ is N, A ¹ is F, A ² and A ³ are CH, and the other substituents are as given in specific example (E4) significance.

The intermediate compound of formula (III) forms another aspect of the invention

Wherein A ¹ , A ² , A ³ , A ⁴ , R ² and Q ² are as defined for formula (I); or a salt thereof. A ¹ , A ² , A ³ , A ⁴ , R ² and Q ^{2 are} preferably the same as those of the corresponding substituents of the compound of the formula (I).

The intermediate compound of formula (IIIb) forms another aspect of the invention

Wherein A ¹ , A ² , A ³ , A ⁴ , R ² and Q ² are as defined for formula (I); or a salt thereof. A ¹ , A ² , A ³ , A ⁴ , R ² and Q ^{2 are} preferably the same as those of the corresponding substituents of the compound of the formula (I).

In a preferred embodiment, the invention provides a compound of formula (III) wherein A ¹ , A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is part of formula (II); In a preferred embodiment, the invention provides a compound of formula (III) wherein A ¹ is C-CN; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is part of formula (II) In another preferred embodiment, the invention provides a compound of formula (III) wherein A ¹ is CF; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is formula (II) In a further preferred embodiment, the invention provides a compound of formula (III) wherein A ¹ is C-Cl; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is formula ( Part of II); in another preferred embodiment, the invention provides a compound of formula (III) wherein A ⁴ is CF; A ² , A ³ and A ¹ are CH; R ² is hydrogen; Q ² is a formula a portion of (II); in another preferred embodiment, the invention provides a compound of formula (III), wherein A ⁴ is C-OMe; A ² , A ³ and A ¹ are CH; R ² is hydrogen; ² is a part of formula (II); in another preferred embodiment, the invention provides a compound of formula (III), wherein A ⁴ is N; ² , A ³ and A ¹ are CH; R ² is hydrogen; Q ² is a part of formula (II); in another preferred embodiment, the invention provides a compound of formula (III), wherein A ⁴ is N; A ¹ is CN, A ² and A ³ are CH; R ² is hydrogen; Q ² is a part of formula (II); in another preferred embodiment, the invention provides a compound of formula (III), wherein A ⁴ Is N; A ¹ is F, A ² and A ³ are CH; R ² is hydrogen; Q ² is a part of formula (II); in another preferred embodiment, the invention provides a compound of formula (IIIb), Wherein A ¹ is C-CF3; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is a part of formula (II); in a preferred embodiment, the invention provides formula (IIIb) a compound wherein A ¹ , A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is a part of formula (II); in another preferred embodiment, the invention provides a compound of formula (IIIb) Wherein A ¹ is C-CN; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is a part of formula (II); and in another preferred embodiment, the invention provides formula (IIIb) a compound wherein A ¹ is CF; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is a part of formula (II); In one embodiment, the invention provides a compound of formula (IIIb) wherein A ¹ is C-Cl; A ² , A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is part of formula (II); In a preferred embodiment, the invention provides a compound of formula (IIIb) wherein A ⁴ is CF; A ² , A ³ and A ¹ are CH; R ² is hydrogen; Q ² is part of formula (II); In another preferred embodiment, the invention provides a compound of formula (IIIb) wherein A ⁴ is C-OMe; A ² , A ³ and A ¹ are CH; R ² is hydrogen; Q ² is formula (II) In a further preferred embodiment, the invention provides a compound of formula (IIIb) wherein A ⁴ is N; A ² , A ³ and A ¹ are CH; R ² is hydrogen; Q ² is formula (II) a portion; in another preferred embodiment, the invention provides a compound of formula (IIIb) wherein A ⁴ is N; A ¹ is CN, A ² and A ³ are CH; R ² is hydrogen; Q ² is a portion of (II); in another preferred embodiment, the invention provides a compound of formula (IIIb) wherein A ⁴ is N; A ¹ is F, A ² and A ³ are CH; R ² is hydrogen; ² is a part of formula (II); and in another preferred embodiment, the present invention provides a compound of formula (IIIb), wherein a ¹ is C-CF3 A ^2, A ³ and A ⁴ are CH; R ² is hydrogen; Q ² is a part of formula (II); and

Table 1:

According to formula (I), Table 1 provides 47 compounds of formula (Ia) wherein A ¹ is C-CN, A ² , A ³ and A ⁴ are CH, and Q ² is 2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 2:

According to formula (I), Table 2 provides 47 compounds of formula (Ib) wherein A ⁴ is CF, A ¹ , A ² and A ³ are CH, and Q ² is 2-methyl-5-pentafluoroethyl -4-Trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

table 3:

According to formula (I), Table 3 provides 47 compounds of formula (Ic) wherein A ⁴ is C-OMe, A ¹ , A ² and A ³ are CH, and Q ² is 2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 4:

According to formula (I), Table 4 provides 47 compounds of formula (Id) wherein A ¹ , A ² , A ³ and A ⁴ are CH and Q ² is 2-methyl-5-pentafluoroethyl-4 -Trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in the following table.

table 5:

According to formula (I), Table 5 provides 47 compounds of formula (Ie) wherein A ¹ is C-Cl, A ² , A ³ and A ⁴ are CH, and Q ² is 2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 6:

According to formula (I), Table 6 provides 47 compounds of formula (If) wherein A ¹ is CF, A ² , A ³ and A ⁴ are CH, and Q ² is 2-methyl-5-pentafluoroethyl -4-Trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 7:

According to formula (I), there are 47 compounds of formula (Ig) provided in Table 7, wherein A ¹ is C-CF ₃ , A ² , A ³ and A ⁴ are CH, and Q ² is 2-methyl-5- Pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 8:

According to formula (I), Table 8 provides 47 compounds of formula (Ih) wherein A ⁴ is N, A ¹ , A ² and A ³ are CH, and Q ² is 2-methyl-5-pentafluoroethyl -4-Trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 9:

According to formula (I), Table 9 provides 47 compounds of formula (Ii) wherein A ⁴ is N, A ¹ is CN, A ² and A ³ are CH, and Q ² is 2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 10:

According to formula (I), Table 10 provides 47 compounds of formula (Ij) wherein A ⁴ is N, A ¹ is F, A ² and A ³ are CH, and Q ² is 2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and Q ¹ has the values listed in Table 1.

Table 11:

Table 11 provides nine compounds of formula (IIIb) wherein Q ² is 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and A ¹ , A ² , A ³ and A ⁴ have the values listed in the table below.

Table 12:

Table 12 provides nine compounds of formula (III) wherein Q ² is 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl, R ² is H, and A ¹ , A ² , A ³ and A ⁴ have the values listed in the table below.

The compound of the present invention can be produced by the following method.

(1) A compound of formula (I) wherein G ¹ is oxygen may be present in the presence of a copper or copper catalyst such as copper sulfate or cuprous iodide, and optionally in a base such as N-ethyldiisopropylamine. It is prepared by reacting a compound of the formula (V) with an azide derivative (Q ² -N ₃ ) in the presence of a solvent or a solvent mixture such as tert-butanol or water. In the case of a Cu(II) catalyst, a reducing agent such as sodium ascorbate can be used. In the case of a Cu(0) catalyst, an oxidizing agent such as an amine salt can be used. (See, for example, Angewandte Chemie, International Edition, 2009, Vol. 48, No. 27, pp. 4900-4908 and references cited; Angewandte Chemie, International Edition, 2008 , vol. 47, pp. 2182-2184 and references cited; Chem. Eur. J. (European Chemical Journal), 2006, pp. 51-68 and references cited.

(2) A compound of the formula (V) wherein G ¹ is oxygen may be, for example, DCC (N,N'-dicyclohexylcarbodiimide), EDC (1 ethyl-3-[3-dimethylamine) Propyl-propyl]carbodiimide hydrochloride) or BOP-Cl (bis(2-trioxy-3-) In the presence of a coupling reagent such as pyridine, triethylamine, 4-(dimethylamino)pyridine or diisopropylethylamine, and optionally in the presence of a coupling reagent such as pyridyl)phosphine chloride It is prepared by deuteration of a compound of formula (VI) by a compound of formula (IV) wherein R is OH in the presence of a nucleophilic catalyst such as hydroxybenzotriazole. Optionally, when R is Cl, the deuteration reaction can be carried out under basic conditions (for example, in the presence of pyridine, triethylamine, 4-(dimethylamino)-pyridine or diisopropylethylamine), again It is carried out in the presence of a nucleophilic catalyst as needed. Alternatively, such a reaction can be carried out in a two-phase system containing an organic solvent (preferably ethyl acetate) and an aqueous solvent (preferably sodium hydrogencarbonate solution). Optionally, when R is a C ₁ -C ₆ alkoxy group, the decylamine can be prepared by heating the ester (IV) together with the amine (VI).

(3) A compound of the formula (VI) wherein R ¹ is a C ₁ -C ₆ alkyl group can be reacted by a reductive amination reaction (using an aldehyde or a ketone and a reducing agent such as sodium borohydride to react with an amine) The compound of formula (VI) wherein R ¹ is H is prepared. Alternatively, alkylation can also be achieved by treating the amine with an alkylating agent such as a halogenated alkane in the presence of a base, if desired.

(4) A compound of the formula (I) wherein G ¹ is oxygen can also be produced by reacting a compound of the formula (III) with a compound of the formula (IV) as described in the item (2).

(5) The compound of the formula (III) can be obtained from the same conditions as described in (1) Preparation of a compound of formula (VI).

(6) A compound of the formula (VI) wherein R ¹ is H can be produced by reducing a nitro compound of the formula (VIII), for example, by treatment with tin chloride in an acidic environment or by a metal (for example, iron). Hydrogenation.

(7) A compound of the formula (III) wherein R ¹ is H can be produced by reducing the nitro compound of the formula (IIIb) by the method described in the item (6).

(8) A compound of the formula (IIIb) can be produced from a compound of the formula (VIII) by reacting with an azide derivative Q ² -N ₃ using the same conditions as described in the item (1).

(9) A compound of the formula (I) wherein G ¹ is sulfur can be prepared by treating a compound of the formula (I) wherein G ¹ is oxygen, by a sulfur transfer reagent such as Lawesson's reagent or phosphorus pentasulfide. .

(10) A compound of formula (III) can be obtained from a compound of formula (VI) wherein P is A suitable protecting group is prepared by the same conditions as described in item (1), and then the protecting group P is removed under standard conditions.

(11) A compound of the formula (VIII) may be a compound of the formula (IX) wherein A ¹ , A ² , A ³ and A ⁴ are each independently C-LG or CH, and LG is a leaving group such as fluorine or chlorine. Prepared by reaction with a nucleophile such as an aliphatic alcohol and sodium cyanide.

(12) a compound of the formula (IIIb) (wherein A ¹ , A ² , A ³ and A ^{4 are} as described for the compound of the formula (I)), which may be a compound of the formula (IIIb) (wherein A ¹ , A ² , A ³ and A ⁴ are each independently C-LG or CH, and LG is a leaving group such as fluorine or chlorine), which is prepared by reaction with a nucleophile such as an aliphatic alcohol and sodium cyanide.

14) A compound of the formula (VII) wherein Q _{2 is} as described for the compound of the formula (I) can also be produced by reacting a compound of the formula (I1) with sodium nitrite, followed by sodium azide. See, for example, "Diazo Chemistry I: Aromatic and Heteroaromatic Compounds" (diazo-based chemistry I: aromatic and heteroaromatic compounds) . Zollinger, H. Germany (1994), 380 pages. Publishing company: (VCH, Weinheim, Germany) with referenced references.

15) a compound of formula (II) wherein R 5 is methyl, R 7 is perfluoroethyl, and R 6 is trifluoromethyl, which may be from a compound of formula (IIa) wherein LG is a halogen, such as fluoride or Chloride is prepared by reaction with an azide salt such as sodium azide.

16) Alternatively, the compound of formula (NH2Q2) is not known or can be prepared by methods known to those skilled in the art.

17) The compounds of formula (VIII) and (VI) are not known or can be made by methods known to those skilled in the art.

Compounds of formula (I) are useful for combating and controlling pest infestation, such as Lepidoptera, Diptera, Hemiptera, Thysanoptera, Orthoptera ), pests such as Dictyoptera, Coleoptera, Siphonaptera, Hymenoptera, and Isoptera, and other invertebrate pests such as ticks and nematodes And mollusc pests, etc. Insects, mites, nematodes, and mollusc pests are collectively referred to as pests. These pests that can be used to combat and control using this compound include: agriculture (which includes crops for growing food and fiber products), horticulture, livestock, pets, forestry and vegetable raw materials (eg fruits, booties and A warehousing of wood; involved in the destruction of man-made structures and the spread of human and animal diseases; and harassing pests (such as flies).

Examples of pest species that can be controlled by compounds of formula (I) include: Myzus persicae , Aphis gossypii , Aphis fabae , Lygus spp., and blind mites ( Dysdercus spp.), Nilaparvata lugens , Nephotettixc incticeps , Nezara spp., Euschistus spp., Leptocorisa spp., Western Frankliniella occidentalis , Thrips spp., Leptinotarsa decemlineata , Anthonomus grandis , Aonidiella spp., Trialeurodes spp. ), Bemisia tabaci , Ostrinia nubilalis , Spodoptera littoralis , Heliothis virescens , Helicoverpa armigera , Helicoverpa zea , cotton leaf Sylepta derogata , Pieris brassicae , Plutella xylostella , Agrotis spp., Chilo suppressalis , Locusta migratoria , Chortiocetes terminifera , Diabrotica spp., Panonychus ulmi , Panonychus citri , Tetranychus urticae , Tetranychus cinnabarinus , mandarin Phyllocoptruta oleivora , Polyphagotarsonemus latus , Brevipalpus spp., Boophilus microplus , Dermacentor variabilis , Ctenocephalides felis , Liriomyza spp., Musca domestica , Aedes aegypti , Anopheles spp., Culex spp., Lucillia spp. ) German cockroach ( Blattella germanica ), American cockroach ( Periplaneta americana ), Oriental cockroach ( Blatta orientalis ), termites of the family Ants (such as Mastotermes spp.), termites of the wood termite family (eg new termite species ( Neotermes spp.)), termites of the family Termidae (eg Coptotermes formosanus , Reticulitermes flavipes , R. speratu , R. virginicus , R .hesperus and R. santonensis ), and termites of the termite family (eg, Globitermes sulfureus ), fire ants ( Solenopsis geminata ), primordial ants ( Monmorium pharaonis ), mites ( Dalalinia spp.) and biting Linognathus spp., Meloidogyne spp., Globodera spp. and Heterodera spp., root rot nematode ( Pratylushus spp.), banana perforated nematode Species ( Rhoodopholus spp.), Tylenchulus spp., Haemonchus contortus , Caenorhabditis elegans , Trichostrongylus spp., and Deroceras reticulatum .

Accordingly, the present invention provides a method of combating and controlling insects, mites, nematodes or molluscs comprising an effective amount of a compound of formula (I), or a formula (I), which is insecticidal, acaricidal, nematicidal or molluscicidal. A composition of a compound applied to a pest, where it is (preferably a plant) or a plant or plant propagation material that is susceptible to pests. The compounds of formula (I) are preferably used against insects, mites or nematodes.

螨, such as cotton red spider ( Tetranychus cinnabarinus ), Tetranychus urticae , Panonychus citri , Aculops pelekassi , Tarsonemus spp.

Nematodes, such as Meloidogyne incognita , Bursaphelenchus lignicolus Mamiya et Kiyohara , Aphelenchoides besseyi , Heterodera glycines , and Pratylenchus spp.

In addition, these compounds can also be used to control animal pests, especially in agriculture, horticulture, veterinary establishments, forests, gardens and leisure facilities, and protection. Insects, arachnids, worms, nematodes and mollusks appear in stored products and materials and in sanitary settings. It can be used as a plant protection agent. They are effective against common sensitive and resistant species and against all or part of the growth phase.

These pests include, inter alia:

Of the order Anoplura ( Phthiraptera ), such as the genus Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Pteridium ( Trichodectes spp.).

Arachnida , such as Acarus siro , Aceria sheldoni , Aculops spp., Aculus spp., blunt Amblyomma spp., Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa , Piedia ( Chorioptes spp.), Dermanyssus gallinae , Eotetranychus spp., Epitrimerus pyri , Eutetranychus spp., Eriophyes spp. Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus mactans , Metatetranychus spp., Oligonychus spp., blunt Ornithodoros spp., Panonychus spp., Phyllocoptruta oleivora , Polyphagotarsonemus latus , Psoroptes spp., Rhipicephalus spp.), root mite species (Rhizoglyphus spp.), scabies mite species (Sarcoptes spp.), Middle East Scorpion (Scorpio maurus), Stenotarsonemus spp. , Tetranychus spp tarsal (Tarsonemus spp.), The genus Tetranychus (Tetranychus spp.), Vasates lycopersici .

It belongs to the class of Bivalva , for example, Dreissena spp.

Genus Chilopoda (Chilopoda) are, for example, Geophilus species (Geophilus spp.), Scorpionfish dragonfly species (Scutigera spp.).

Genus Coleoptera (Coleoptera) by, for example, soybean like (Acanthoscehdes obtectus), brown beetle species (Adoretus spp.), Alder leaf beetle (Agelastica alni), beetle species (Agriotes spp.), Powder blowing chafer (Amphimallon solstitialis), furniture Anobium punctatum , Anoplophora spp., Anthonomus spp., Anthrenus , Apogonia spp., Atomaria , Attagenus , and peas Bruchidius obtectus ), Bruchus , Ceuthorhynchus , Cleonus mendicus , Conoderus spp., Cosmopolites , Costelytra zealandica , and Cureulio spp. ), Yang Ganxiang ( Cryptorhynchus lapathi ), Dermestes , Diabrotica , Epilachna , Faustinus cubae , Gibbium psylloides , African unicorn Heteronychus arator , Hylamorpha elegans , Hylotrupes bajulus , Hypera postica , Hypothenemus , Lachnost Erna consanguinea , Leptinotarsa decemlineata , Lissorhoptrus oryzophilus , Lyxus, Lyctus spp., Meligethes aeneus , Taiwanese tortoise ( Melolontha melolontha ), Migdolus spp., Monochamus spp., Naupactus xanthographus , Niptus hololeucus , Oryctes rhinoceros , Oryzaephilus surinamensis , black Otiorrhynchus sulcatus , Oxycetonia jucunda , Phaedon cochleariae , Phyllophaga spp., Popillia japonica , Premnotrypes , Psylliodes chrysocephala , Ptinus spp., Rhizobius ventralis , Rhizopertha dominica , Sitophilus , Sphenophorus , Sternechus ), Symphyletes spp., Tenebrio molitor , Tribolium spp., Trogoderma Spp .), Tychius spp., Xylotrechus spp., Zabrus spp.

Is a member of the Collembola, such as Onychiurus armatus.

It belongs to the genus Dermaptera, such as Forficula auricularia.

A person of the genus Diplopoda, such as the genus Blancoi guttulatus.

Diptera (Diptera), such as Aedes spp., Anopheles spp., Bibio hortulanus, Calliphora erythrocephala, Ceratitis Capitata), Chrysomyia spp., Cochliomyia spp., Cordylobia anthropophaga, Culex spp., Cuterebra spp., olive oil Fruit fly (Dacus oleae), Dermatobia hominis, Drosophila spp., Fannia spp., Gastrophilus spp., Hylemyia spp. , Hypoposca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Musca spp., indica (Nezara spp.), Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia, Stomoxys spp., horsefly (Tabanus spp.), Tannia spp., Tipula paludosa, Wohlfahrtia spp.

Gastropoda, such as Arion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Vertebral Lymnaea spp., Oncomelania spp., Succinea spp.

Genus helminths, such as Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp .), Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp. ), Coopereria spp., gun-like liver suction Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, multi-atrial Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opshorchis spp .), Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni, Strongyloides stercoralis spp., Stronyloides, Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancrofti .

Protozoa such as Eimeria can also be further controlled.

Of the genus Heteroptera, such as Anasa tristis, Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma livida, Caverierius spp., Cimex spp. Creeoniades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp. ), Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp., Oebalus spp., 蝽Pentomidae, Piesema quadrata, Piezodorus spp., Psallus seriatus, Pseudacysta persea, Rhodnius spp., Coco brown scorpion (Sahlbergella) Singularis), Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.

Homoptera, such as Acyrthosipon spp., Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus barodensis, Aleurothrixus spp., Amrasca spp. Anuraphis cardui, Aonidiella spp., Aphanostigma piri, Aphis spp., Arboridia apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii, Brachycolus spp., Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita Onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Dalbulus spp. Dialeurodes spp., Diaphorina spp., Diaspis spp., Doralis spp., Drosicha spp., Dysaphis spp. , Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Euceleli bilobatus, Geococcus coffeae, Homalodisca coagulata , Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi ), Macrosiphum spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp. Lettuce (Nasonovia ribisnigri), Nephotettix spp., Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., corn flower wing Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., pear-shaped original wax mites (Protopulvinaria pyriformis), Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp, Pteromalus spp., Pyrilla spp., Quadrazipiotus spp, Quesada gigas, Rastrococcus spp., Rhopalosip Spp.), Saissetia spp., Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., white back fly Sogatella furcifera, Sogatodes spp., Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp. Typhlocyba spp., Unaspis spp., Viteus vitifolii.

Of the order Hymenoptera, such as Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa species Vespa spp.).

Isopoda, such as Armadillidium vulgare, Oniscus asellus, Porcellio scaber.

Isoptera, such as Reticulitermes spp., Odontotermes spp.

Lepidoptera, such as Acronicta major, Aedia leucomelas, Agrotis spp., Alabama argillacea, cognac Anticarsia spp., Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Cheimatobia brumata, Chilo spp., Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus spp , Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa spp., Feltia spp., Galleria mellonella, Bombyx mori Genus (Helicoverpa spp.), Heliothis spp., Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, and Lyphygma spp .), Lithocolletis blancardella, Lithophea antennata, Loxalactis albicosta, Lymantria spp., Malacosoma neustria, Mazestra brassicae, Mocis Repanda, Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea, cotton red bollworm (Pectinop) Hora gossypiella), Phyllocnistis citrella, Pieris spp., Plutella xylostella, Prodenia spp., Pseudaletia spp., Pseudoplusia includens , European mackerel (Pyrausta nubilalis), Spodoptera spp., Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana, pink Trichoplusia spp.

Orthoptera, such as Acheta domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa spp., Leucophaea maderae, planthopper Genus (Locusta spp.), Melanoplus spp., Periplaneta americana, and Desert locust (Schistocerca gregaria).

It belongs to the genus Siphonaptera, such as Ceratophyllus spp., Xenopsylla cheopis.

It belongs to the general class (Symphyla), such as the white cutworm (Scutigerella immaculata).

Of the order Thysanoptera, such as Balithrips biformis, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Kakothrips spp., Rhipiphorothrips cruentatus , Scirthothrips spp., Taeniothrips cardamoni, Thrips spp.

It belongs to the order of Thysanura, such as Lepisma saccharina.

The phytoparasitic nematodes include Anguina spp, Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp., and double-sided cutting edges. Ditylenchus dipsaci, Globodera spp., Heliocotylenchus spp., Heterodera spp., Long needles Spp.), Meloidogyne spp., Pratylenchus spp., Radopholus similis, Rotylenchus spp., Trichodorus spp. Tylenchorhynchus spp., Tylenchulus spp., Tylenchulus semipenetrans, Xiphinema spp.

Furthermore, in the field of veterinary medicine, the novel compounds of the present invention are effective for combating various different harmful animal parasitic pests (endoparasites and ectoparasites) such as insects and helminths.

Examples of such animal parasitic pests include the pests described below.

Examples of insects include Gasterophilus spp., Stomoxys spp., Trichodectes spp., Rhodnius spp., Ctenocephalides canis, temperate zone Cimx lecturius, Ctenocephalides felis, Lucilia cuprina and other similar insects.

Examples of cockroaches include Ornithodoros spp., Ixodes spp., Boophilus spp., and the like.

In the veterinary field (for example in the field of veterinary medicine), the active compounds according to the invention are effective against animal parasites, as well as ectoparasites or endoparasites.

The term endoparasite specifically includes helminths such as aphids, nematodes or trematodes, and protozoa such as bisporus coccidia.

The ectoparasites are usually arthropods, especially like flies (biting and foraging), parasitic maggots, scorpions, head lice, guanines, fleas and other similar insects; or such as ticks (such as hard crickets or Soft mites, such as itch, autumn owl, guanine and other similar mites.

These parasites include:

Of the order Anoplura, such as Haematopinus spp., Linognathus spp., Pediculus spp., Phthirus spp., Solenopotes Spp.); The following are special examples: Linognathus setosus, Linognathus vituli, Linognathus ovillus, Linognathus oviformis, Linognathus pedalis, Narrow-faced 颚虱(Linognathus stenopsis), Haematopinus asini macrocephalus, Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus corporis, Phylloera vastatrix, Phthirus pubis , Solenopotes capillatus; belonging to Mallophagida and belonging to Amblycera and Ischnocerina, such as Trimenopon spp., Menopon spp., duck plague (Trinoton spp.), Bovicola spp., Werneckiella spp., Lepikentron spp., Damalina spp., Trichodectes spp., Felicola spp.; example: Bovicola bovis, Bovicola ovis, Bovicola limbata, Damalina bovis, Trichodectes canis, Felicola subrostratus, Bovicola caprae, Lepikentron ovis, Werneckiella equi; belonging to the genus Diptera and belonging to the genus Nematocerina and Brachycerina, such as the genus Aedes spp. (Anopheles spp.), Culex spp., Simulium spp., Eusimulium spp., Phlebotomus spp., Lutzomyia spp. , Culicoides spp., Chrysops spp., Odagmia spp., Wilhelmia spp., Hybomitra spp., Atylotus spp. Tabanus spp., Haematopota spp., Philipomyia spp., Braula spp., Musca spp., Hydrotaea spp., Stomoxys spp., Black horn flies (Haematobia spp.), Morellia spp., Fannia spp., Glossina spp., Calliphora spp., Lucilia spp., Golden fly species Chrysomyia spp.), Wohlfahrtia spp., Sarcophaga spp., Oestrus spp., Hypoderma spp., Gasterophilus spp., horse虱fly species (Hippobosca spp.) , Lipoptena spp., Melophagus spp., Rhinoestrus spp., Tipula spp.; the following is a special case: Aedes aegypti (Aedes Aegypti), Aedes albopicta (Aedes albopictus), Aedes taeniorhynchus, Anopheles gambiae, Anopheles maculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex pipiens (Culex tarsalis), Fannia canicularis, Sarcophaga carnaria, Stomoxys calcitrans, Tipula paludosa, Lucilia cuprina, Lucilia sericata , Mumulium reptans, Phlebotomus papatasi, Phlebotomus longipalpis, Odagmia ornata, Wilhelmia equina, Boophthora erythrocephala, Tabanus bromius, Tabanus spodopterus, abanus atratus, Tabanus Sudeticus, Hybomitra ciurea, Chrysops caecutiens, Chrysops relictus, Haematopota pluvialis, Haematopota italica, Musca autumnalis, Musca domestica, Haematobia irritans irritans ), Haematobia irritans exigua, Haematobia stimulans, Hydrotaea irritans, Hydrotaea albipuncta, Chrysomya chloropyga, Chrysomya bezziana, Sheep flies Oestrus ovis), Hypoderma bovis, Hypoderma lineatum, Goat cattle fly (Przhe) Valskiana silenus), Dermatobia hominis, Melophagus ovinus, Lipoptena capreoli, Lipoptena cervi, Hippobosca variegata, Hippotosca equina, Gasterophilus intestinalis, red tail Gasterophilus haemorroidalis, Gasterophilus inermis, Gasterophilus nasalis, Gasterophilus nigricornis, Gasterophilus pecorum, Braula Coeca); belonging to the genus Siphonapterida, such as Pulex spp., Ctenocephalides spp., Tunga spp., Xenopsylla spp., horn Genus (Ceratophyllus spp.); the following are special examples: Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans, Xenopsylla cheopis Of the genus Heteropterida, for example, Cimex spp., Triatoma spp., Rhodnius spp., Panstrongylus spp.

Of the genus Blattarida, such as Blatta orientalis, Periplaneta americana, Blattela germanica, Supella spp. (eg brown belt 蜚蠊 ( Suppella longipalpa)); belonging to Acari (Acarina) and belonging to the mutated (Meta-) and mesostigmata, such as Argas spp., Ornithodorus spp., deafness Genus (Otobius spp.), Ixodes spp., Amblyomma spp., Rhipicephalus (Boophilus spp.), Dermacentor spp .), Haemophysalis spp., Hyalomma spp., Dermanyssus spp., Rhipicephalus spp. (original genus of multi-hosted ticks) , Ornithonyssus spp., Pneumonyssus spp., Raillietia spp, Pneumonyssus spp., Sternostoma spp., Corrugated (Sternostoma spp.) Varroa spp.), Acarapis spp.; the following are special cases Son: Argas persicus, Argas reflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus (Boophilus microplus), Rhipicephalus (Rhipicephalus) Boophilus) decoloratus), Rhipicephalus (Boophilus) annuulas, Rhipicephalus (Boophilus) calceratus, Hyalomama anatolicum, Hyalomma aegypticum, Hyalomma marginatum, Hyalomma transiens, valgus Rhipicephalus evertsi, Ixodes ricinus, Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus , Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna, Haemaphysalis punctata, Haemaphysalis cinnabarina, Haemaphysalis otophila, dogs Bloody (Haemaphysalis leachi), Haemaphysalis longicorni, Dermacentor marginatus, Dermacentor reticulatus, flowers Dermacentor pictus, Dermacentor albipictus, Dermacentor andersoni, Dermacentor variabilis, Hyalomma mauritanicum, Rhipicephalus sanguineus, capsular fan Rhipicephalus bursa, Rhipicephalus appendiculatus, Rhipicephalus capensis, Rhipicephalus turanicus, Rhipicephalus zambeziensis, beauty Amblyomma americanum, Amblyomma variegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyomma cajennense, chicken prick Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssus sylviarum, Varroa jacobsoni, Actinedida (Prostigmata) and pink mites (Actinedida (Prostigmata)) Acaridida (Astigmata)), such as Acarapis spp., Cheyletiella spp., Ornithocheyletia spp., Myobia spp., Psorergates spp., Demodex spp., Trombula spp. , Listrophorus spp., Acarus spp., Tyrophagus spp., Caloglyphus spp., Hypodectes spp., Pterolichus spp., Psoroptes spp. , Choriopteres spp., Otodectes spp., Sarcoptes spp., Notoedres spp., Knemidocoptes spp., Cymbidium (Cytodites spp.), larvae (Laminosioptes spp.); the following are special Son: Cheyletiella yasguri, Cheyletiella blakei, Demodex canis, Demodex bovis, Demodex ovis, Goat Demodex Demodex caprae), Demodem equi, Demodex caballi, Demodex suis, Neocrombicula autumnalis, Neotrombicula desaleri, Neoschongastia xerothermobia, Trombula akamushi, Otodectes cynotis, cat ears Notoedres cati, Sarcoptis Canis, Sarcoptes bovis, Sarcoptes ovis, Sarcoptes rupicaprae (S. caprae), Sarcoptes equi, Sarcoptes suis, Psoroptes ovis, Psoroptes cuniculi, Psoroptes equi, Chorioptes bovis, Psoergates ovis, Pneumonyssoidic mange, Pneumonyssoides caninum, Acarapis woodi ).

The active compounds according to the invention are also suitable for controlling arthropods, helminths and protozoa which attack animals.

These animals include agricultural livestock such as cattle, sheep, goats, horses, pigs, donkeys, camels, buffalo, rabbits, chickens, turkeys, ducks, geese, farmed fish and bees.

In addition, these animals include domesticated animals such as dogs, cats, cage birds, ornamental fish, and known experimental animals such as hamsters, guinea pigs, voles and house mice.

By controlling these arthropods, worms and/or protozoa to achieve reduced death and improved effectiveness (for meat, milk, hair, skin, eggs, honey and other similar products) and the health of the host animal. Thus, by using the active compound according to the invention, the work of raising animals can be made more economical and simple.

For example, preventing or interrupting parasites from drawing the host's blood may be desirable.

At the same time, controlling parasites can help prevent the spread of infectious agents.

The term "control" as used herein relates to the veterinary field and indicates that the active compound is effective against the respective parasitic animals that have been infected with such parasites. The incidence of the object has dropped to a level that is harmless.

More precisely, the term "control" as used herein means that the active compound is effective in killing the respective parasites, inhibiting their growth or inhibiting their proliferation. In general, the active compounds according to the invention may be administered directly when used to treat animals.

These compounds are preferably administered as a pharmaceutical composition which may contain pharmaceutically acceptable excipients and/or adjuvants known in the art.

In the veterinary field and in the field of animal husbandry, active compounds are mainly administered (for example, by administration) in a known manner, such as tablets, capsules, syrups, drenches, granules, ointments, boluses, irrigation. In the form of food and suppository, enteral administration; parenteral administration, such as injection (intramuscular, subcutaneous, intravenous, intraperitoneal, etc.), implantation; nasal administration; such as medicated bath or dipping, spraying, Pouring and dropping, washing, spreading, by dermal administration, and using molded articles containing active compounds (such as collars, ear tags, tails, limb bands, halters) , marking devices, etc.) to assist in the administration of drugs.

The active compound can be formulated as a shampoo or as a suitable formulation for use in aerosols, unpressurized sprays such as pump sprays, and atomizer sprays.

For use in livestock, poultry, livestock and such animals, the active compounds of the invention may be formulated (for example, powders, wettable powders ["WP"], emulsions, emulsified concentrates ("EC"), fluids (flowable) , a homogeneous solution and an aqueous suspension concentrate ["SC")), which contains from 1 to 80% by weight of the active compound, either directly or after dilution (eg 100 to 10,000 times) Dilution rate) used, or used in chemical baths.

When used in the veterinary art, the active compounds according to the invention can be used in combination with suitable synergists or other active compounds, for example acaricides, insecticides, insect repellents and antiprotozoal agents.

In the present invention, all of these insecticidal agents against harmful biological substances are represented by insecticides.

When used as an insecticide, the active compound of the present invention can be prepared by using a conventional formulation form.

Examples of formulation forms include solutions, emulsions, wettable powders, water-dispersible granules, suspensions, powders, foaming agents, ointments, tablets, granules, aerosols, natural and synthetic materials which have been infiltrated into the active compound, Microcapsules, seed coating agents, formulations used in conjunction with combustion appliances (eg, smoke boxes, cans, coils, or other such burners), ULV (cold fog, warm fog), etc. .

These formulations can be made using methods known per se.

For example, the active compound may be mixed with a developer (ie, an aqueous diluent or carrier; a liquefied gas diluent or carrier; a solid diluent or carrier), and optionally mixed with a surfactant (ie, an emulsifier and/or dispersant and/or A blowing agent) whereby a formulation is made.

For example, if water is to be used as the developer, an organic solvent can be used as an auxiliary solvent.

Examples of aqueous diluents or carriers include aromatic hydrocarbons (e.g., xylene, toluene, alkylnaphthalene, and the like), chlorinated aromatic hydrocarbons or chlorinated aliphatic hydrocarbons (e.g., chlorobenzene, vinyl chloride, methylene chloride), aliphatic hydroxy groups. (such as cyclohexane), paraffin (such as mine Oil fraction), alcohols (such as butanol, ethylene glycol and its ethers and esters and analogs), ketones (such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and the like) , strong polar solvents (such as dimethylformamide, dimethyl hydrazine and the like), as well as water and the like. The liquefied gas diluent or carrier may be a gaseous substance such as butane, propane, nitrogen, carbon dioxide, and a halogenated hydrocarbon, which is gaseous at normal temperature and pressure. Examples of solid diluents include powdered natural minerals (e.g., kaolin, clay, talc, chalk, quartz, erectite, montmorillonite, diatomaceous earth, and the like), powdered synthetic minerals (e.g., highly dispersed Capric acid, alumina, citrate and the like) and the like. Solid carriers of particles include powdered and sieved rocks (such as calcite, marble, pumice, sepiolite, dolomite and the like), synthetic particles of organic and inorganic powders, fine-grained organic materials (eg sawdust, coconut shells) , corn cobs, tobacco stalks and the like) and the like. Examples of emulsifiers and/or blowing agents include nonionic and anionic emulsifiers [e.g., polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers (e.g., alkyl aryl polyglycol ethers), alkyl sulfonates , alkyl sulfates, aryl sulfonates and the like], albumin hydrolysates and the like. Examples of the dispersing agent include lignin sulfite waste liquid and methyl cellulose.

Fixing agents can also be used in formulations (powders, granules, emulsions), and examples of fixing agents include carboxymethylcellulose, natural and synthetic polymers (eg, gum arabic, polyvinyl alcohol). , polyvinyl acetate and the like) and the like. Colorants may also be used, examples of which include inorganic pigments (such as cerium oxide, titanium oxide, Prussian blue, and the like), organic dyes (such as alizarin dyes, azo dyes or metal phthalocyanine dyes), and trace elements (such as iron). Salt, manganese salt, boron salt, copper salt, cobalt salt, molybdenum salt and zinc salt). In general, the formulations may contain the active compound in an amount ranging from 0.1 to 95% by weight, preferably from 0.5 to 90% by weight. The compounds according to the invention can also be used as mixtures with other active compounds (for example insecticides, baits, bactericides, acaricides, nematicides, fungicides, growth regulators, herbicides and the like) Commercial formulations are coexisting and coexist in the form of application prepared from these formulations.

The compounds according to the invention and which are present in commercial applications are present in an amount sufficient to vary greatly.

In practical applications, the concentration range of the compound according to the present invention may range from 0.0000001 to 100% by weight, preferably from 0.00001 to 1% by weight.

The compounds according to the invention can be used by conventional methods suitable for the application form.

When used to inhibit hygienic pests and pests involved in stored products, the active compounds of the present invention are effective in stabilizing alkali on lime materials and have excellent residual effects on wood and soil. The compounds of the present invention may possess good characteristics in terms of application rate, residual formulation, selectivity, toxicity, production method, high activity, wide range of control, safety, and resistant organisms (for example, organophosphorus agents and/or Or the control of a drug-resistant pest of a urethane agent.

More specific examples of the invention will be described below.

Compounds of formula (I) are useful for combating and controlling pest infestation, such as Lepidoptera, Diptera, Hemiptera, Thysanoptera, Orthoptera, Nettle, Sheath Pests such as Hymenoptera, Hymenoptera, Hymenoptera, and Isoptera, and other invertebrate pests such as ticks, nematodes, and mollusc pests. Insects, mites, nematodes, and mollusc pests are collectively referred to as pests. These pests that can be used to combat and control using this compound include: agriculture (meaning crops that include food and fiber products), horticulture, livestock, companion animals, forestry and vegetable raw materials (such as fruits) Warehousing of sputum, timber and wood; involved in the destruction of man-made structures and the spread of human and animal diseases; and harassing pests (such as flies).

For example, the compounds of the present invention can be used for turf, ornamental plants (e.g., flowers, shrubs, broadleaf trees, or evergreen plants such as conifers), as well as for tree injection, pest management, and the like.

The compounds of the present invention are useful for controlling animal home pests, including: ants, bed bugs (adults), bees, beetles, boxelder Bugs, carpenter bees, carpet beetles, cockroaches, tobacco beetles, clover cockroaches, cockroaches Confused Flour Beetle, Earwigs, Firebrats, Fleas, Flies, Lesser Grain Borers, Millipedes, Mosquitoes, Red Valley Pirates, Rice Rice Weevils, Sawgrass, Silverfish, Sowbugs, Spiders, Termites, Ticks, Wasps, Storks, Storks, Flies, Small Beetles (Pseudo-Beetles, Concealed Beetles) And scavenger beetle), mosquitoes, worms, scorpions, spiders, spider mites (two-pointed spider mites, non-clawed scorpion scorpions).

The compounds of the present invention are useful for controlling ornamental plant pests, including: ants (including exotic fire ants), armyworms, Azalea caterpillar, aphids, and bagworms. Black vine weevils (adults), Boxelder bugs, Budworms, California oakworms, Cankerworms, crickets, crickets, night worms, Oriental sky caterpillar, Elm leaf beetles, European sawflies, Fall webworms, Flea beetles, forest caterpillars, Gypsy moth larvae, Japan Beetle (adult), June beetle (adult), Lace bugs, leaf-feeding caterpillar, Leafhoppers, Liriomyza (adult), Leaf rollers, Leaf skeletonizers , Midges, mosquitoes, Oleander moth larvae, Pillbugs, Pine sawflies, Pine shoot beetles, Pinetip moths, Plant bugs, Root weevils, Sawflies, Scale insects (reptiles), spiders, Spittlebugs, striped beetles, striped oak worms, thrips, Tip moth, Tussock moth larvae, wasp, tea fine (Broadmite) s), Brown softscales, California redscales (reptiles), Clover mites, Mealybugs, Pineneedles (reptiles), spider mites (Spider) Mites), whiteflies.

The compounds of the present invention can be used to control pests of turf, including: ants (including exotic fire ants), Spodoptera litura, ticks, ticks, night larvae, crickets, fleas (adults), grass mites, Japanese beetles (adults) ), millipedes, mites, mosquitoes (adults), tide worms, grasshoppers, moths, ticks (including species that spread Lyme disease), Bluegrass billbug (adults), black chafers (adults), cockroaches, Fleas (adults), Grubs (inhibition), Hyodes weevils (adults), Mole Crickets (scorpion and young adults), ticks (mature adults), and Chinch Bugs.

Examples of pest species that can be controlled by compounds of formula (I) include: Myzus persicae , Aphis gossypii , Aphis fabae , Lygus spp., and blind mites ( Dysdercus spp.), Nilaparvata lugens , Nephotettixc incticeps , Nezara spp., Euschistus spp., Leptocorisa spp., Western Frankliniella occidentalis , Thrips spp., Leptinotarsa decemlineata , Anthonomus grandis , Aonidiella spp., Trialeurodes spp. ), Bemisia tabaci , Ostrinia nubilalis , Spodoptera littoralis , Heliothis virescens , Helicoverpa armigera , Helicoverpa zea , cotton leaf Sylepta derogata , Pieris brassicae , Plutella xylostella , Agrotis spp., Chilo suppressalis , Locusta migratoria , Chortiocetes terminifera , Diabrotica spp., Panonychus ulmi , Panonychus citri , Tetranychus urticae , Tetranychus cinnabarinus , mandarin Phyllocoptruta oleivora , Polyphagotarsonemus latus , Brevipalpus spp., Boophilus microplus , Dermacentor variabilis , Ctenocephalides felis , Liriomyza spp., Musca domestica , Aedes aegypti , Anopheles spp., Culex spp., Lucillia spp. ) German cockroach ( Blattella germanica ), American cockroach ( Periplaneta americana ), Oriental cockroach ( Blatta orientalis ), termites of the family Ants (such as Mastotermes spp.), termites of the wood termite family (eg new termite species ( Neotermes spp.)), termites of the family Termidae (eg Coptotermes formosanus , Reticulitermes flavipes , R. speratu , R. virginicus , R .hesperus and R. santonensis ), and termites of the termite family (eg, Globitermes sulfureus ), fire ants ( Solenopsis geminata ), primordial ants ( Monmorium pharaonis ), mites ( Dalalinia spp.) and biting Linognathus spp., Meloidogyne spp., Globodera spp. and Heterodera spp., root rot nematode ( Pratylushus spp.), banana perforated nematode Species ( Rhoodopholus spp.), Tylenchulus spp., Haemonchus contortus , Caenorhabditis elegans , Trichostrongylus spp., and Deroceras reticulatum .

The compounds of the present invention are useful for controlling pests on a variety of plants, including soybeans (e.g., 10-70 grams per hectare in some cases), corn (e.g., in some cases 10-70) G/ha), sugar cane (for example, 20-200 g/ha in some cases), 苜蓿 (example) For example, in some cases 10-70 g/ha), Brassica (for example, 10-50 g/ha in some cases), canola (eg rapeseed) (for example, in In some cases 20-70 g/ha), potatoes (including sweet potatoes) (for example, 10-70 g/ha in some cases), cotton (for example, in some cases 10-70 g/ Haha), rice (for example, 10-70 g/ha in some cases), coffee (for example, 30-150 g/ha in some cases), citrus (for example, 60 in some cases) -200 g/ha), almonds (for example, 40-180 g/ha in some cases), fruits and vegetables (for example, tomatoes, peppers, peppers, eggplants, cucumbers, pumpkins, etc.) (for example, at some In some cases 10-80 g/ha), tea (for example, 20-150 g/ha in some cases), bulbous vegetables (eg, onions, leeks, etc.) (for example, in some cases Applying 30-90 g/ha), grapes (for example, 30-180 g/ha in some cases), pome fruit (eg, apples, pears, etc.) (eg, in some cases Use 30-180 g/ha), stone fruit (eg, pear, plum, etc.) (eg, 30-180 g/ha in some cases).

Compounds of the invention may be used in soy, such as to control the South American Maize seedlings Oligochroa (Elasmopalpus lignosellus), Argentina pocket insects (Diloboderus abderus), Diabrotica South America (Diabrotica speciosa), Sternechus subsignatus, Formicidae (Formicidae), black cutworm ( Agrotis ypsilon ), Julus spp., Anticarsia gemmatalis , Megascelis spp., Procornitermes spp., Gryllotalpidae , Nezara viridula , Piezodorus Spp .), Acrosternum spp., Neomegalotomus spp., Cerotoma trifurcata , Japanese cock ( Papiillia japonica ), Edessa spp., Liogenys fuscus , Euchistus heros , stalk borer, Scaptocoris castanea , horned tortoise Genus ( Phyllophaga spp.), Pseudoplusia includens , Spodoptera spp., Bemisia tabaci , Agriotes spp. The compounds of the present invention are preferably used in soybeans to control Diloboderus abderus , Diabrotica speciosa , Nezara viridula , Piezodorus spp., Acrosternum spp., beans. Cerotoma trifurcata , Japanese poplar ( Popillia japonica ), Euchistus heros , Phyllophaga spp., Agriotes spp.

The compounds of the present invention can be used in corn to control Euchitus heros , Dichelops furcatus , Diloboderus abderus , Elasmopalpus lignosellus , Spodoptera frugiperda , Nezara viridula , bean leaf beetle (Cerotoma trifurcata), Japan chafer (Popillia japonica), black cutworm (Agrotis ypsilon), the South American leaf beetle (Diabrotica speciosa), Heteroptera, Procornitermes spp., Scaptocoris castanea, Formicidae (Formicidae), Julus spp., Dalbulus maidis , Diabrotica virgifera , Mocis latipes , Bemisia tabaci , heliothis spp., four Tetranychus spp., Thrips spp., Phyllophaga spp., Scaptocoris spp., Liogenys fuscus , Spodoptera spp. ), Ostrinia spp., Sesamia spp., Agriotes spp. The compounds of the present invention are preferably used in corn to control Euchitus heros , Dichelops furcatus , Diloboderus abderus , Nezara viridula , Cerotoma trifurcata , Popillia japonica , Diabrotica speciosa , Diabrotica virgifera , Tetranychus spp., Thrips spp., Phyllophaga spp., Shield-like bug species ( Scaptocoris spp.), Agriotes spp.

The compounds of the present invention are useful in sugar cane to control Sphenophorus spp., termites, Mahanarva spp., and the like. The compounds of the invention are preferably used in sugar cane to control termites, Mahanarva spp.

The compounds of the invention can be used in alfalfa to control, for example, Hypera brunneipennis , Hypera postica , Colias eurytheme , Collops spp., Empoasca solana, Epitrix , Geocoris spp., Lygus hesperus , Lygus lineolaris , Spissistilus spp, Spodoptera spp., Trichoplusia ni . The compounds of the present invention are preferably used in alfalfa to control Hypera brunneipennis , Hypera postica , Empoasca solana , Epitrix , Lygus hesperus , and pasture blindness. Lygus lineolaris , Trichoplusia ni .

The compounds of the present invention can be used in Brassica plants to control, for example, Plutella xylostella , Pieris spp., Mamestra spp., Plusia spp., Trichoplusia ni ), Phyllotreta spp., Spodoptera spp., Empoasca solana , Thrips spp., Spodoptera spp., Spodoptera spp. ( Delia spp.). The compounds of the present invention are most suitable for use in Brassica plants to control Plutella xylostella , Pieris spp., Plusia spp., Trichoplusia ni , Phyllotreta spp. ), Thrips spp.

The compounds of the present invention are useful in canola such as canola to control, for example, Meligethes spp., Ceutorhynchus napi , Psylloides spp.

The compounds of the present invention are useful in potato (including sweet potato) to control, for example, the genus Empoasca spp., the genus Leptinotarsa spp., the genus Diabrotica speciosa , and the genus Phthorimaea spp. .), Paratrioza spp., Maladera matrida , Agriotes spp. Preferred compounds of the invention for potato (including sweet), to control the species leafhopper (Empoasca spp.), Colorado potato beetle genus (Leptinotarsa spp.), Leaf beetle America (Diabrotica speciosa), the genus wolfberry fruit moth (Phthorimaea Spp .), Paratrioza spp., Agriotes spp.

The compounds of the present invention are useful in cotton to control, for example, Anthonomus grandis , Pectinophora spp., Heliothis spp., Spodoptera spp. ), Tetranychus spp., Empoasca spp., Thrips spp., Bemisia tabaci , Lygus spp., horns Phyllophaga spp., Scaptocoris spp. Compounds of the invention preferred for cotton, to control the cotton boll weevil (Anthonomus grandis), the genus Tetranychus (Tetranychus spp.), Species leafhopper (Empoasca spp.), Thrips (Thrips spp.), Oxalyl seed bugs (Lygus spp.), the genus gill angle beetle (phyllophaga spp.), species of class shield bug (Scaptocoris spp.).

The compounds of the present invention can be used in rice to control such as Leptocorisa spp., Cnaphalocrosis spp., Chilo spp., Scirpophaga spp., Lissorhoptrus spp. ( Oebalus pugnax ). The compounds of the present invention are preferably used in rice to control Leptocorisa spp., Lissorhoptrus spp., and Oebalus pugnax .

The compounds of the present invention are useful in coffee to control, for example, Hypothenemus Hampei , Perileucoptera Coffeella , Tetranychus spp. The compounds of the present invention are useful in coffee to control Hypothenemus Hampei , Perileucoptera Coffeella .

The compounds of the present invention can be used in citrus to control, for example, Panonychus citri , citrus rust ( Phyllocoptruta oleivora ), Brevipalpus spp., Diaphorina citri , flea horse Genus ( Scirtothrips spp.), Thrips spp., Unaspis spp., Cerstitis capitata , Phyllocnistis spp. The compounds of the present invention are preferably used in citrus to control Panonychus citri , citrus rust ( Philyllocoptruta oleivora ), Brevipalpus spp., Diaphorina citri , flea Scirtothrips spp., Thrips spp., Phyllocnistis spp.

The compounds of the invention are useful in almonds to control, for example, Amyelois transitella , etranychus spp.

The compound of the present invention can be used for fruits and vegetables, including tomatoes, peppers, peppers, eggplants, cucumbers, pumpkins, etc., to control Thrips spp., Tetranychus spp., tea fines. Genus ( Polyphagotarsonemus spp.), Aculops spp., Empoasca spp., Spodoptera spp., heliothis spp. flies (Tuta absoluta), species of leafminer (Liriomyza spp.), silverleaf whitefly (Bemisia tabaci), is a whitefly (Trialeurodes spp.), Paratrioza spp ., western flower thrips (Frankliniella occidentalis, Frankliniella spp., Anthonomus Spp ., Phyllotreta spp., Amrasca spp., Epilachna spp., Halyomorpha spp., Scirtothrips spp., Leucinodes spp., Neoleucinodes The compound of the present invention is preferably used for fruits and vegetables, including tomatoes, peppers, peppers, eggplants, gherkins, pumpkins, etc., to control, for example, Thrips spp., Tetraychus spp .), Tea genus ( Polyphago) Tarsonemus spp.), Aculops spp., Empoasca spp., Spodoptera spp., heliothis spp., Liriomyza spp. Tuta absoluta), species of leafminer (Liriomyza spp.), Paratrioza spp ., western flower thrips (Frankliniella occidentalis), Frankliniella spp. , Amrasca spp., thrips jump (Scirtothrips spp.), Minge genus (Leucinodes Spp .), Neoleucinodes spp.

The compounds of the present invention can be used in teas to control, for example, Pseudaulacaspis spp., Empoasca spp., Scirtothrips spp., Caloptilia theivora . The compounds of the invention are preferably used in teas to control the genus Empoasca spp., Scirtothrips spp.

The compounds of the present invention are useful for bulbous vegetables (including onions, leeks, etc.) to control, for example, Thrips spp., Spodoptera spp., Heliothis spp. . The compounds of the invention are preferably used in bulbous vegetables (including onions, leeks, etc.) to control Thrips spp.

Compounds of the invention can be used in grapes, such as to control the species leafhopper (Empoasca spp.), Flowers genus wings pomonella (Lobesia spp.), Frankliniella spp ., Thrips (Thrips spp.), Tetranychus genus ( Tetranychus spp.), Rhipiphorothrips Cruentatus , Eotetranychus Willamettei , Erythroneura Elegantula , Scaphoides spp. The compounds of the invention are preferably used in grapes to control Frankliniella spp., Thrips spp., Tetranychus spp., Rhipiphorothrips Cruentatus , Scaphoides spp.

The compounds of the present invention can be used in pome fruits (including apples, pears, etc.) to control such as Cacopsylla spp., Psylla spp., Panonychus ulmi , Cydia pomonella . . The compounds of the present invention are preferably used in pome fruit (including apples, pears, etc.) to control Cacopsylla spp., Psylla spp., and Panonychus ulmi .

The compounds of the present invention can be used in stone fruits to control, for example, Grapholita molesta , Scirtothrips spp., Thrips spp., Frankliniella spp., Tetraychus spp .). The compounds of the invention are preferably used in stone fruit to control Scirtothrips spp., Thrips spp., Frankliniella spp., Tetranychus spp. Accordingly, the present invention may provide a method of combating and/or controlling an animal pest, such as an invertebrate pest, the method comprising applying a pesticidally effective amount of a compound of formula (I) to a pest, where Or a plant that is susceptible to pests. In particular, the present invention provides a method of combating and/or controlling insects, mites, nematodes or molluscs, i.e., an insecticidally, acaricidal, nematicidally or molluscicially effective amount of a compound of formula (I), or a formula (I) A composition of a compound applied to a pest, where it is (preferably a plant) or a plant susceptible to pests. The compounds of formula (I) are preferably used against insects, mites or nematodes.

The term "plant" as used herein includes seedlings, shrubs and trees. should Understand that crops also include resistance to herbicides or various herbicides (eg ALS inhibitors, GS inhibitors, EPSPS inhibitors, PPO inhibitors and HPPD inhibitors) by conventional breeding methods or genetic engineering techniques. Sex crops. There have been examples of crops that have been bred by conventional methods and are resistant to imidazolinones such as imazamox, known as Clearfield® summer rape (canola). In the market, there are already examples of crops that are resistant to herbicides by genetic engineering methods, including commercially available corn varieties that are resistant to glyphosate and glufosinate, under the product names RoundupReady® and LibertyLink®. .

The so-called crops can also be those that have been resistant to pests by genetic engineering techniques, such as Bt corn (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and Bt potato (can Anti-Colorado beetle). An example of Bt corn is the NK® brand Bt 176 Corn Mix (Syngenta Seeds). Examples of genetically modified plants are KnockOut® (corn), Yield Gard® (corn), NuCOTIN 33B® (cotton), Bollgard® (cotton), NewLeaf® (potato), NatureGard® and Protexcta, one or more of these plants. The genes encode insecticidal resistance and release one or more toxicities. Therefore, plant crops or seed materials can simultaneously resist herbicides and insect foraging (stacked gene transfer events). For example, seeds can release a pesticidal Cry3 protein while being tolerant to glyphosate.

Crops should also be understood as crops obtained by conventional breeding methods or genetic engineering techniques, as well as crops containing so-called export traits such as better storage stability, higher nutritional value and better taste. .

In order to use the compound of formula (I) as an insecticide, acaricide, nematicide or kill A mollusc agent, which is applied to a pest, where it is located, or susceptible to pests, typically formulating a compound of formula (I) into a composition incorporating the following: in addition to the compound of formula (I) itself A suitable inert diluent or carrier, and optionally a surfactant (SFA). SFA, a chemical that reduces interfacial tension and thereby induces changes in other properties (such as dispersibility, emulsifying, and wet) to modify an interface (eg, liquid/solid, liquid/air or liquid/liquid interface) Characteristics. All compositions (solid and liquid formulations) preferably comprise (by weight) from 0.0001 to 95%, more preferably from 1 to 85%, for example from 5 to 60%, of the compound of formula (I). The composition is generally used for controlling pests, and the application rate of the compound of the formula (I) is from 0.1 to 10 kg per hectare, preferably from 1 to 6 kg per hectare, more preferably from 1 to 1 kg per hectare.

If used in seed dressing, the application rate of the compound of formula (I) is generally from 0.0001 g to 10 g (e.g., 0.001 g or 0.05 g) per kg of seed, preferably from 0.005 g to 10 g, more preferably 0.005. Gram to 4 grams.

Another aspect of the invention provides a composition comprising a pesticidally effective amount of a compound of formula (I), especially an insectic, acaricidal, nematicidally or molluscicidal effective amount of a compound of formula (I) and suitable A carrier or diluent for the composition of insecticidal, acaricidal, nematicidal or molluscicidal animals. Preferably, the composition is a pesticidal, acaricidal, nematicidal or molluscicidal composition.

The composition can be selected from a number of formulation types including powder (DP), soluble powder (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules. Agent (GR) (slow or fast release), available Soluble concentrate (SL), oil soluble liquid (OL), ultra low volume liquid (UL), emulsified concentrate (EC), dispersible concentrate (DC), emulsion (water in oil (EW) and oil package Water (EO)), microemulsion (ME), suspension concentrate (SC), aerosol, nebulization/smoke formulation, capsule suspension (CS) and seed treatment formulations. The type of formulation selected in any of the examples will depend on the particular intended purpose, as well as the physical, chemical, and biological properties of the compound of formula (I).

A powder (DP) can be prepared by reacting a compound of formula (I) with one or more solid diluents (eg, natural clay, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, diatomaceous earth, chalk). Mixing diatomaceous earth, calcium phosphate, calcium carbonate, magnesium carbonate, sulfur, lime, flour, talc and other organic and inorganic solid carriers, and mechanically grinding the mixture into a fine powder.

By mixing a compound of formula (I) with one or more water-soluble inorganic salts such as sodium bicarbonate, sodium carbonate or magnesium sulfate, or with one or more water-soluble organic solids such as polysaccharides Preparing a soluble powder by selectively mixing with one or more wetting agents, mixing with one or more dispersing agents, or mixing with a mixture of wetting agents and dispersing agents to improve water dispersibility/solubility ( SP). This mixture is then ground to a fine powder. Similar compositions can also be granulated to form water soluble granules (SG).

By promoting the compound of formula (I) with one or more solid diluents or carriers, one or more wetting agents (and preferably one or more dispersing agents), and optionally one or more suspensions to facilitate in the liquid Dispersion to prepare wettable powder (WP). This mixture is then ground to a fine powder. Similar compositions can also be granulated to form a water dispersible granule (WG).

There are two ways to form a granule (GR): a compound of formula (I) a mixture of one or more powdered solid diluents or carriers, or from preformed blanks, in the form of granules (by means of porous particulate material (eg, pumice, erectite, bleaching earth, diatomaceous earth or ground corn cob) Intermediate absorption of a compound of formula (I) (or a solvent thereof, which is absorbed in a suitable reagent) to form a granule); or in a hard core material such as sand, citrate, mineral carbonate, sulfate or phosphate The compound of formula (I) (or its solvent, absorbed in a suitable reagent) is absorbed and dried if necessary. Reagents commonly used to aid absorption or absorption, including solvents (eg, aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones, and esters) and adhesives (eg, polyvinyl acetate, polyvinyl alcohol, dextrin, sugar, and vegetable oils) ). One or more other additives (such as emulsifiers, wetting agents or dispersing agents) may also be included in the granules.

Dispersible concentrates (DC) can be prepared by dissolving the compound of formula (I) in water or an organic solvent such as a ketone, alcohol or glycol ether. These solutions may contain surfactants (for example to improve water dilution or to prevent crystallization in a spray can).

An emulsified concentrate (EC) or an oil-in-water emulsion can be prepared by dissolving a compound of formula (I) in an organic solvent, optionally comprising one or more wetting agents, one or more emulsifiers or a mixture of the foregoing. (EW). Organic solvents suitable for use in EC include aromatic hydrocarbons (e.g., alkylbenzenes or alkylnaphthalenes, exemplified in SOLVESSO 100, SOLVESSO 150, and SOLVESSO 200; SOLVESSO is a registered trademark), ketones (e.g., cyclohexanone or methylcyclohexanone). And alcohols (such as benzyl alcohol, decyl or butanol), N-alkylpyrrolidone (such as N-methylpyrrolidone or N-octylpyrrolidone), fatty acid dimethyl decylamine (such as C8-C10 fatty acid dimethyl decylamine) and chlorocarbons. EC products after adding water, since It can then be emulsified to produce an emulsion of sufficient stability to be sprayed by suitable equipment. Preparation of EW involves obtaining a compound of formula (I) in liquid form (if it is not liquid at ambient temperature, it may melt at a reasonable temperature, typically below 70 ° C), or in the form of a solution ( I) The compound (by dissolving it in a suitable solvent) and then emulsifying the resulting liquid or solution in water containing one or more SFAs under high shear to produce an emulsion. Suitable solvents for EWs include vegetable oils, chlorocarbons (such as chlorobenzene), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes), and other suitable and water-soluble organic solvents.

Microemulsions (ME) can be prepared by naturally producing a thermally stable, isotropic liquid formulation by mixing water with one or more blends containing one or more SFAs. The initial form of the compound of formula (I) is water or a solvent/SFA blend. Solvents suitable for use in MEs include the solvents described above for ECs or EWs. The ME can be an oil-in-water or water-in-oil system (which can be determined by conductivity measurements to determine which system is present), and can also be adapted to mix water-soluble and oil-soluble pesticides in the same formulation. ME is suitable for dilution in water, including continuing to maintain the form of a microemulsion or forming a conventional oil-in-water emulsion.

The suspension concentrate (SC) may comprise an aqueous or non-aqueous suspension of finely insoluble solid particles of the compound of formula (I). The compound of formula (I) (optionally using one or more dispersing agents) can be milled in a suitable medium by ball milling or bead milling to prepare SC, whereby a suspension of the finely divided compound can be prepared. The composition may contain one or more wetting agents and a suspension may be added to reduce the rate of particle precipitation. Alternatively, the compound of formula (I) can be dry milled and added The water containing the aforementioned reagent is used to make the desired final product.

Aerosol formulations comprise a compound of formula (I) and a suitable propellant (e.g., n-butane). The compound of formula (I) may also be dissolved or dispersed in a suitable medium (e.g., water or a water soluble liquid such as n-propanol) to provide a composition for use in a non-pressurized hand-actuated spray pump.

The compound of formula (I) can be mixed with the pyrotechnic mixture in a dry state to form a composition suitable for producing a fumes containing the compound in a confined space.

The capsule suspension (CS) can be prepared in a similar manner to the preparation of the EW formulation, but with the addition of an additional polymerization stage whereby water dispersion of the oil droplets is obtained, wherein each oil droplet is encapsulated with a polymeric outer shell and contains a compound of formula (I), and optionally a carrier or diluent. The polymeric shell can be made using an interfacial polycondensation reaction or a coacervation procedure. The composition provides a controlled release effect of the compound of formula (I) and can be used for seed treatment. The compound of formula (I) can also be formulated in a biodegradable polymer matrix to provide a slow, controlled release of the compound.

One or more additives may be included in the composition to enhance the bio-exhibition of the composition (e.g., by improving wettability, retention or surface distribution; the rain resistance of the treated surface; or the uptake of the compound of formula (I) And mobility to improve). Such additives include surfactants, spray additives based on certain mineral oils or natural vegetable oils (such as soybean and rapeseed oil), and other bio-enhancing adjuvants that can help or modify compounds of formula (I). Blend of the component of action.

The compound of formula (I) may also be formulated as a seed treatment formulation, such as a powder Compositions, including powders for dry seed treatment (DS), water-soluble powders (SS) or water-dispersible powders (WS) for mud water treatment, or liquid compositions, including suspension concentrates (FS), solvents (LS) or capsule suspension (CS). The preparation methods of the DS, SS, WS, FS and LS compositions are very similar to the preparation methods of the above DP, SP, WP, SC and DC compositions, respectively. The composition for treating the seed may include an agent (e.g., mineral oil or film-forming barrier) for assisting in the attachment of the composition to the seed.

The humectant, dispersant and emulsifier can be cationic, anionic, amphoteric or nonionic surface SFA.

Suitable SFAs of the cationic type include quaternary ammonium compounds such as cetyltrimethylammonium bromide, imidazolines and amine salts.

Suitable anionic SFAs include alkali metal salts of fatty acids, salts of aliphatic monoesters of sulfuric acid (for example sodium lauryl sulfate), salts of sulfonated aromatic compounds (for example sodium dodecylbenzene sulfonate, dodecane) Calcium benzenesulfonate, naphthalene sulfonate, and a mixture of sodium diisopropylnaphthalenesulfonate and sodium triisopropylnaphthalenesulfonate, ether sulfate, alcohol ether sulfate (eg, lauryl polyether-3) Sodium sulphate), ether carboxylates (eg sodium lauryl polyether-3 carboxylate), phosphate esters (one or more fatty alcohols with phosphoric acid (mainly monoesters) or phosphorus pentoxide (mainly diesters) Products under reaction, such as lauryl alcohol and tetraphosphoric acid; in addition, these products can be ethoxylated), sulfonated amber amide, paraffin or olefin sulfonate, aminoethanesulfonate and lignin Salt.

Suitable SFAs of the amphoteric type include betaines, propionates and glycinates.

Suitable SFAs of the nonionic type include condensation products of alkylene oxides, Such as ethylene oxide, propylene oxide, butylene oxide, or a mixture thereof with a fatty alcohol (such as oleyl alcohol or cetyl alcohol) or an alkyl phenol (such as octylphenol, nonylphenol or octyl cresol) a partial ester obtained from a long-chain fatty acid or hexitol anhydride; a condensation product of the above partial ester with ethylene oxide; a block polymer (including ethylene oxide and propylene oxide); an alkanolamine; a monoester (eg fatty acid polyethylene glycol esters); amine oxides (eg dodecyl dimethyl amine oxide); and lecithin.

Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite).

The compound of formula (I) can be administered using any known method of administering a pesticidal compound. For example, whether it is formulated or not, it can be applied directly to where pests or pests are located (such as habitats of pests or growing plants that are susceptible to pests) or applications. Apply to any part of the plant, including leaves, stems, shoots or roots, or to the seed before planting it, or to plants that have grown up, or other medium in which plants are to be planted (eg, around the roots) Soil, general soil, paddy water or hydroponic cultivation system, or it can be sprayed, sprinkled, applied by immersion in a soil or aqueous environment, applied as a cream or ointment, Steam application, either by dispensing or adding a composition (eg, a particulate composition or a composition encapsulated in a water soluble bag).

The compounds of formula (I) may also be injected into plants or sprayed onto plants using electrodynamic spraying techniques or other minor methods, or applied using land or aerial irrigation systems.

Compositions for use as aqueous preparations (e.g., aqueous solutions or dispersions) are typically supplied as a concentrate containing a high proportion of active ingredient (the concentrate is added to the water prior to use). These concentrates, which can contain DCs, SCs, ECs, EWs, MEs, SGs, SPs, WPs, WGs, and CSs, are typically capable of withstanding long-term storage and can be added to form aqueous formulations after such long-term storage. And these agents can remain homogenous for a sufficient period of time for application by conventional spray equipment. Depending on the use, such aqueous preparations may contain varying amounts of the compound of formula (I) (for example from 0.0001 to 10% by weight).

The compound of formula (I) can be used in a mixture with a fertilizer such as a fertilizer containing nitrogen, potassium or phosphorus. Suitable formulation types include fertilizer granules. The content of the compound of the formula (I) in the mixture is preferably up to 25% by weight of the compound.

Accordingly, the present invention also provides a fertilizer composition comprising a fertilizer and a compound of formula (I).

The compositions of the present invention may comprise other biologically active compounds, such as micronutrients or compounds having the following activity: fungicidal activity, or plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.

The compound of formula (I) may be the sole active ingredient of the composition, or it may, where appropriate, be combined with one or more additional active ingredients (eg pesticides such as insecticides, fungicides or Herbicide, or synergist or plant growth regulator, etc.)) mixed. Additional active ingredients may provide a composition having a broader spectrum of efficacy, or a more durable effect where the pest is present; synergizing or supplementing the activity of the compound of formula (I) (eg, by increasing the rate of effect or by overcoming resistance) Sexual approach); or assist in overcoming or preventing individual The ingredients develop resistance. The particular additional active ingredient will depend on the intended utility of the composition.

The compounds of the present invention are also useful in the field of animal health, for example, they can be used to prevent parasitic invertebrate pests, and are more suitable for preventing invertebrate pests in or on parasitic objects. Examples of pests include nematodes, flukes, mites, flies, cockroaches, ticks, lice, fleas, ticks, and ticks. The animal may be a non-human animal, such as an animal associated with agriculture, such as a cow, pig, sheep, goat, horse or donkey, or a companion animal such as a dog or cat.

In another aspect, a compound of the invention can be used in a therapeutic treatment.

In another aspect, the invention relates to a method of controlling an invertebrate pest that is parasitic in and out of an animal, comprising administering a pesticidally effective amount of a compound of the invention. For example, the mode of administration can be oral, parenteral or external, such as the surface of an animal's body. In another aspect, the invention relates to a compound that controls an invertebrate pest that is parasitic in and out of an animal. In another aspect, the invention relates to the use of a compound of the invention for the manufacture of an agent for controlling invertebrate pests in vivo and in vitro.

In another aspect, the invention relates to a method of controlling parasitic invertebrate pests comprising administering a pesticidally effective amount of a compound of the invention to an environment in which the animal is inhabited.

In another aspect, the invention relates to a method of protecting an animal from parasitic invertebrate pests comprising administering a pesticidally effective amount of a compound of the invention to an animal. In another aspect, the invention relates to A compound used to protect animals from parasitic invertebrate pests. In another aspect, the invention relates to the use of a compound of the invention for the manufacture of an agent for protecting an animal from parasitic invertebrate pests.

In another aspect, the invention provides a method of treating an animal suffering from a parasitic invertebrate pest comprising administering a pesticidally effective amount of a compound of the invention to an animal. In another aspect, the invention relates to a compound that can be used to treat an animal suffering from a parasitic invertebrate pest. In another aspect, the invention relates to the use of a compound of the invention to manufacture an agent for use in treating an animal suffering from a parasitic invertebrate pest.

In another aspect, the invention provides a pharmaceutical composition comprising a compound of the invention and an excipient suitable for use in medicine.

The compounds of the invention may be used alone or in combination with one or more other biologically active ingredients.

In another aspect, the invention provides a combination product comprising a pesticidally effective amount of component A and a pesticidally effective amount of component B. Among them, the A component is a compound of the present invention, and the B component is a compound as described below.

The compounds of the invention may be used in combination with an insect repellent. Such insect repellents include compounds selected from macrolide compounds, such as: ivermectin, avermectin, abamectin, emamectin, Eprinomectin, doramectin, serracin (selamectin), moxidectin, nemadectin and milbemycin derivatives, as described in EP-357460, EP-444964 and EP-594291. Other insect repellents include semi-synthetic and biosynthetic avermectin/milbimycin derivatives such as those described in US-5015630, WO-9415944 and WO-9522552. Other insect repellents also include benzimidazoles such as albendazole, cambendazole, fenbendazole, flubendazole, mebendazole , oxfendazole, oxibendazole, parbendazole, and other members of this class. Other insect repellents include imidazothiazole and tetrahydropyrimidine, for example: tetramisole, levamisole, pyrantel pamoate, oxantel or morantel. Other insect repellents include flukicides (such as triclabendazole and clorsulon), as well as cestocides such as praziquantel and Isey. Tyr (epsiprantel).

The compounds of the invention may be used in combination with the derivatives and analogues of the insect repellent paraherquamide/marcfortine species, as well as antiparasitic Oxazolines, such as those disclosed in US-5478855, US-4639771, and DE-19520936 Oxazoline.

The compounds of the present invention can be used in combination with the following general derivatives and analogs of the two-side oxymorpholine antiparasitic agent (as described in WO-9615121), as well as anthelmintic active cyclic depsipeptides, such as those Described in The peptides of WO-9611945, WO-9319053, WO-9325543, EP-626375, EP-382173, WO-9419334, EP-382173 and EP-503538.

The compounds of the invention may be used in combination with other ectoparasites, such as fipronil; pyrethroids; organophosphates; insect growth regulators such as lufenuron; Ecdysone agonists, such as tebufenozide and analogs; neonicotinoids, such as imidacloprid and the like.

The compounds of the present invention can be used in combination with terpenoid alkaloids, such as those described in International Patent Application Publication No. WO 95/19363 or WO 04/72086, especially the compounds disclosed therein.

Other examples of such biologically active compounds that can be used in combination with the compounds of the invention include, but are not limited to, the following:

Organophosphates: acephate, azamethiphos, azinphos-ethyl, azinphos-methyl, bromophos, ethyl Bromophos-ethyl, cadusafos, chlorethoxyphos, chlorpyrifos, chlorfenvinphos, chlormephos, demeton, Demeton-S-methyl, demeton-S-methyl sulphone, dialifos, diazinon, dichlorvos, Baizhi Dicrotophos, dimethoate, disulfoton, ethion, ethoprophos, etrimfos, famphur, Fenamiphos, fenitrothion, fensulfothion, fenthion, flupyrazofos, fonofos, formothion, fosthiazate, feida Heptophophos, isazofos, isothioate, isoxathion, malathion, mecaprifos, methamidophos, methidathion, Methyl-balazon, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, paraoxon, bar Parathion, parathion-methyl, phenthoate, phosalone, phosfolan, phosphocarb, yishen ( Phosmet), phosphamidon, phorate, phoxim, pirimiphos, pirimiphos-methyl, profenofos, chlorpyrifos Propaphos, propetamphos, prothiofos, pyraclofos, pyridaphenthion Quinaphos, sulprofos, temephos, terbufos, tebupirimfos, tetrachlorvinphos, thimeton, Triazophos, trichlorfon, vamidothion.

Carbamates: alanycarb, aldicarb, 2-sec-butylphenyl methylcarbamate, benfuracarb, carbaryl, carbofuran, Carbosulfan, cloethocarb, ethiofencarb, fenoxycarb, fenthiocarb, furathiocarb, HCN-801, isoprocarb, Indoxacarb, metiocarb, methomyl, 5-methyl-m-cumenylbutyryl(methyl)carbamate, oxamyl, pirimicarb, propoxur ), thiodicarb, thiofanox, triazamate, UC-51717.

Pyrethroid pesticides: acrinathin, allethrin, alphametrin, 5-benzyl-3-furanyl(E)-(1 R)-cis-2,2-dimethyl-3-( 2-sided oxythiophene -3-ylidenemethyl)cyclopropanecarboxylate, bifenthrin, beta-cyfluthrin, cyfluthrin, a-cypermethrin, beta-cypermethrin Beta-cypermethrin), bioallethrin, bioallethrin ((S)-cyclopentylisomer), bioresmethrin, bifenthrin, NCI-85193, cycloprothrin , cyhalothrin, cythithrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, ether Ethyl ester (ethofenprox), fenfluthrin (fenfluthrin), fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluocyanine Fluvalinate (D isomer), imiprothrin, cyhalothrin, lambda-cyhalothrin, permethrin, phenyl ether Phenophane, prallethrin, pyrethrins (natural product), fenfenyl ( Resmethrin), tetramethrin, transfluthrin, theta-cypermethrin, silafluofen, t-fluvalinate, tefluthrin, tetra Tralomethrin, Zeta-cypermethrin.

Arthropod growth regulators: a) Chitin synthesis inhibitors: benzoylureas: chlorfluazuron, diflubenzuron, fluzuron, flucycloxuron ), flufenoxuron, hexaflumuron, velfenone, novaluron, teflubenzuron, triflumuron, buprofezin, benzene Diofenolan, hexythiazox, etoxazole, chlorfentazine; b) ecdysone antagonists: halofenozide, methoxy worm Methoxy (methoxyfenozide), tebufenozide; c) juvenoids: pyriproxyfen, methoprene (including S-methoprene), phenoxy Fenoxycarb); d) Lipid biosynthesis inhibitor: spirodiclofen.

Other antiparasitic agents: acequinocyl, amitraz, AKD-1022, ANS-118, azadirachtin, Bacillus thuringiensis, bensultap , bifenazate, binapacryl, bromopropylate, BTG-504, BTG-505, camphechlor, cartap, ethyl chlorobenzilate ), chlordimeform, chlorfenapyr, chromafenozide, clothianidine, cyromazine, diacloden, diafenthiuron, DBI-3204 , dinactin, dihydroxymethyldihydroxypyrrolidine, dinobuton, dinocap, endosulfan, ethiprole, ethiprofen (ethofenprox) ), quinacline (fenazaquin), fluoroquinone (flumite), MTI-800, fenpyroximate, fluacrypyrim, flubenzimine, flubrocythrinate, flufenzine, flufenprox, fluproxyfen, halofenprox, flu Hydramethylnon, IKI-220, kanemite, NC-196, neem guard, nidinorterfuran, nitenpyram, SD-35651, WL-108477, pirydaryl, propargite, protrifenbute, pymethrozine, 哒Pyridaben, pyrimidifen, NC-1111, R-195, RH-0345, RH-2485, RYI-210, S-1283, S-1833, SI-8601, flumethrin Silafluofen), silomadine, spinosad, tebufenpyrad, tetradifon, tetranactin, thiacloprid, thiocyclam, worm (thiamethoxam), tolfenpyrad, triazamate, triethoxyspinosyn, trinactin, verbutin, vertalec, YI-5301.

Fungicides: acibenzolar, aldimorph, ampropylfos, andoprim, azaconazole, azoxystrobin, benaraxyl, benomyl, dipropylphosphine ( Bialaphos), blasticidin-S, Bordeaux mixture, bromuconazole, bupirimate, carpropamid, captafol, Captan, carbendazim, chlorfenazole, chloroneb, chloropicrin, chlorothalonil, chlozolinate, oxychlorination Copper oxychloride, copper salt, cyflufenamid, cymoxanil, cyproconazole, cyprodinil, cyprofuram, RH-7281, Diclocymet, diclobutrazole, diclomezine, dicloran, Difenoconazole, RP-407213, dimethomorph, domoxystrobin, diniconazole, diniconazole-M, dodine, edifenphos ), epoxiconazole, Famoxadone, fenamidone, fenarimol, fenbuconazole, fencaramid, fenpiclonil, fenpropidin, fenpropimorph, yam Fetin acetate, fluazinam, fludioxonil, flumetover, flumorf/flumorlin, fentin hydroxide, fluoxastrobin, fluquinconazole, fluoride Flusilazole, fluolanil, flurifaol, folpet, fosetyl-aluminium, furalaxyl, furametapyr, hexaconazole Hexaconazole), ipconazole, iprobenfos, iprodione, isoprothiolane, kasugamycin, krsoxim-methyl, mancozeb Mancozeb, maneb, mefenoxam, mepronil, metalaxyl, metconazole, metominostrobin/fenominostrobin , metafenone, myclobutanil, neo-asozin, nicofigen orysastrobin, Oxedixyl, penconazole, pencycuron, probenazole, prochloraz, propamocarb, propioconazole, proquinazid, prothioconazole Prothioconazole), pyrifenox, pyraclostrobin, pyrimethanil, pyroquilon, quinoxyfen, spiroxamine, sulfur, Tebuconazole, tetrconazole, thiabendazole, thifluzamide, thiophanate-methyl, thiram, tiadinil, three Triadimefon, triadimenol, tricyclazole, trifloxystrobin, triticonazole, validamycin, vinclozin.

Biologics: Bacillus thuingiensis ssp.aizawai, kurstaki, Bacillus thuringiensis delta-endotoxin, baculovirus, entomopathogenic bacteria, viruses and fungi.

Bactericide: chlortetracycline, oxytetracycline, streptomycin.

Other biological agents: enrofloxacin, febantel, penicillin G diethylamine ethyl ester (penethamate), moloxicam, cefalexin, kanamycin, gram benzene Pimobendan, clenbuterol, omeprazole, tiamulin, benazepril, pyriprol, cefquinome, florfenicol (florfenicol), ethyl acetamide (bererelin), cefovecin, tulathromycin, ceftiour, carprofen, metaflumizone, praziquarantel, triclabendazole.

When the compound of the present invention is used in combination with other active ingredients, it is preferably the same as the following (wherein "Tx" means a compound of the formula (I), especially a compound selected from Tables 1 to 120, which is specific to the compound The active ingredients produce synergistic effects) in combination. Yidaamine + Tx, enfloxacin + Tx, praziquantel + Tx, pyrantel p-hydroxypyrimidine + Tx, non-ban Tai + Tx, penicillin G diethylaminoethyl ester + Tx, moloxicam + Tx, cephalosporin Azide + Tx, kanamycin + Tx, Phenbenzidine + Tx, Clenbuterol + Tx, Fenpney + Tx, Ivermectin + Tx, Omeprazole + Tx, Sulm Tx, benazepril + Tx, milbemycin + Tx, chlortetracycline + Tx, worm +Tx, pyriprol+Tx, deltamethrin+Tx, cefquinome+Tx, florfenicol+Tx, ethylguanamine+Tx, cefovecin+Tx, taramycin+Tx, ceftiour+Tx, salad菌素+Tx, carprofen+Tx, cyanofluorfen+Tx, mosastatin+Tx, methoprene (including S-methoprene)+Tx, clorsulon+Tx, pyriazine+Tx, Amitraz + Tx, tricbendazole + Tx, avermectin + Tx, abatatin + Tx, indomethacin + Tx, eplenomycin + Tx, dermaquinin + Tx , serramycin + Tx, nemadacin + Tx, albendazole + Tx, candidazole + Tx, fenbendazole + Tx, fluorobenzazole + Tx, mebendazole + Tx, oxfendazole + Tx, opiateazole + Tx, pabendazole + Tx, tetraimidazole + Tx, levamisole + Tx, pyrithione + Tx, okexon + Tx, molena + Tx, tricbendazole +Tx, ezetine + Tx, Fenpney + Tx, Lucendron + Tx, ecdysone + Tx or Defenol + Tx; more preferably, Enfloxacin + Tx, Praziquantel + Tx , pyrantel p-hydroxypyrimidine + Tx, non-ban Tai + Tx, penicillin G diethylaminoethyl ester + Tx, moloxicam + Tx, cephalexin + Tx, kanamycin + Tx, pectin / Tx, Clenbuterol + Tx, omeprazole +Tx, thiolamin + Tx, benazepril + Tx, pyriprol + Tx, cefquinome + Tx, florfenicol + Tx, ethyl decylamine + Tx, cefovecin + Tx, taramycin + Tx , ceftiour+Tx, serramycin + Tx, carprofen + Tx, mustardatin + Tx, clorsulon + Tx, pyriazine + Tx, eplenomycin + Tx, dermametine + Tx, serramycin + Tx, nemadacin + Tx, albendazole + Tx, candidazole + Tx, fenbendazole + Tx, fluorobenzazole + Tx, mebendazole + Tx, oxfendazole +Tx, albendazole + Tx, pabendazole + Tx, tetraimidazole + Tx, levamisole + Tx, pyrimidine wave + Tx, okexon + Tx, molena + Tx, trichlorobenzene Oxazole + Tx, Ecetaxel + Tx, Lucendron + Tx or ecdysone + Tx; even more preferably, Enfloxacin + Tx, praziquantel + Tx, pyrantel p-hydroxypyrimidine + Tx, Non-ban Tai + Tx, penicillin G diethylaminoethyl ester + Tx, moloxicam + Tx, cephalexin + Tx, kanamycin + Tx, pectidine / Tx, clenbuterol + Tx, Ogilvy Carbazole + Tx, thiolam + Tx, benazepril + Tx, pyriprol + Tx, cefquinome + Tx, florfenicol + Tx, ethyl decylamine + Tx, cefovecin + Tx, tyranomycin +Tx, ceftiou r+Tx, serramycin + Tx, carprofen + Tx, mustardatin + Tx, clorsulon + Tx or pyrantel + Tx.

Examples of ratios include 100:1 to 1:6000, 50:1 to 1:50, 20:1 to 1:20, especially from 10:1 to 1:10, 5:1 to 1:5, 2:1 To 1:2, 4:1 to 2:1, 1:1, or 5:1, 5:2, 5:3, 5:4, 4:1, 4:2 or 4:3, or 3:1 , 3:2, 2:1, 1:5, 2:5, 3:5, 4:5, 1:4, 2:4, 3:4, 1:3, 2:3 or 1:2, or 1:600, 1:300, 1:150, 1:35, 2:35, 4:35, 1:75, 2:75 or 4:75, or 1:6000, 1:3000, 1:1500, 1 : 350, 2:350, 4:350, 1:750, 2:750 or 4:750. And we know that these mixing ratios should be based on the weight ratio on the one hand and Moerby on the other.

Particular attention should be paid to this combination: the point of action of the additional active ingredient is different from that of the compound of formula I. In some instances, if at least one parasitic invertebrate pest control with similar control range but different points of action is combined The active ingredient is particularly advantageous for the management of resistance. Thus, the compound of the invention may comprise a pesticidally effective amount of a compound of formula I, as well as a pesticidally effective amount of at least one additional parasitic invertebrate pest controlling active ingredient having a similar range of control but different points of action.

Those skilled in the art recognize that because under the environmental and physiological conditions, the salt of the compound is commensurate with its corresponding non-salt form, the salt form has the same biological utility as the non-salt form.

Thus, the various compound salts of the present invention (and the active ingredients used in combination with the active ingredients of the present invention) may be useful if used to control invertebrate pests and animal parasites. Salts include acidic addition salts containing inorganic or organic acids such as hydrobromic acid, hydrochloric acid, nitric acid, phosphoric acid, sulfuric acid, acetic acid, butyric acid, fumaric acid, lactic acid, maleic acid, malonic acid, oxalic acid, and sodium. Acid, salicylic acid, tartaric acid, 4-toluenesulfonic acid or valeric acid. The compounds of the invention also include N-oxides. Accordingly, the invention includes combinations of the compounds of the invention (including N-oxides and salts thereof) and an additional active ingredient, including N-oxides and salts thereof.

Compositions useful for animal health may also contain formulation adjuvants and additives, i.e., formulation auxiliaries well known to those skilled in the art (some of which may be considered as solid diluents, liquid diluents or interfaces). Active agent). Such formulation adjuvants and additives can be controlled: pH (buffer), foaming during processing (defoamer such as polyorganosiloxane), precipitation of active ingredient (suspension), viscosity (thixotropy thickening) Agent), growth of microorganisms in the container (antimicrobial agent), product freezing (antifreeze), color (dye/pigment dispersant), detergent (film former or adherent), evaporation (evaporation retarder) and others Provisioning Property attribute. Examples of the film former include polyvinyl acetate, polyvinyl acetate copolymer, polyvinylpyrrolidone-polyvinyl acetate copolymer, polyvinyl alcohol, polyvinyl alcohol copolymer, and wax. Examples of formulation adjuvants and additives include the adjuvants and additives listed in McCutcheon Volume 2: "Functional Materials" published by McCutcheon's division of The Manufacturing Confectioner Publishing Co. Annual International and North American editions; and PCT publication WO 03/024222.

The compounds of the invention may be employed without the use of an adjuvant, but the most common application would be a formulation comprising one or more active ingredients containing a suitable carrier, diluent and surfactant, It may be combined with food, depending on the intended end use. One of the application methods involves spraying a water dispersant or a refined oil solution of a combination product. Compositions containing the following ingredients generally enhance the efficacy of the compound: spray oil, concentrated spray oil, spreading agents, adjuvants, other solvents and synergists such as piperonyl butoxide. For such sprays, the spray can be sprayed from a variety of spray containers, such as cans, bottles or other containers, by means of a pump or from a pressurized container such as a pressurized aerosol spray can. Such spray compositions can take a variety of forms such as, for example, spraying, wet mist, foam, smoke or mist. Thus, such spray compositions can further comprise propellants, blowing agents, and the like, if desired. It should be noted that a spray composition comprising a pesticidally effective amount of a compound of the invention and a carrier. Specific examples of such spray compositions comprise a pesticidally effective amount of a compound of the invention and a propellant. Representative propellants include but not Limited to methane, ethane, propane, butane, isobutane, butene, pentane, isopentane, neopentane, pentene, hydrofluorocarbon, chlorofluorocarbon, dimethyl ether, and mixtures thereof . It should be noted that a spray composition (and a method of using such a spray composition dispensed from a spray container) is used to control at least one parasitic invertebrate pest selected from the group consisting of: mosquitoes, black flies , fly, deer fly, horsefly, wasp, wasp, bumblebee, tick, spider, ant, cockroach and the like (including individual control or combination control).

Control of animal parasites, including controlling external parasites that are parasitic on the surface of the host animal (eg, shoulders, armpits, abdomen, inner thighs), as well as parasitic inside the body of the host animal (eg, stomach, intestines, lungs, blood vessels, Internal parasites of subcutaneous, lymphoid tissue. External parasites or pests that transmit diseases include: ticks, ticks, scorpions, mosquitoes, flies, crickets and fleas. Internal parasites include heartworm, hookworms and worms. The compounds of the invention are particularly useful in combating external parasitic pests. The compounds of the invention may be suitable for providing systemic and/or non-systemic control for this in terms of animal parasite infestation or infection.

The compounds of the present invention are useful for combating parasitic invertebrate pests that invade animal individuals, including wild animals, livestock and farm animals. The term livestock refers to (one or more) domesticated animals, and is particularly raised in an agricultural environment to assist in the production of agricultural products such as food or fiber, or to provide animal power; examples of livestock include cattle, sheep, goats, and horses. , pigs, crickets, camels, buffalo, rabbits, hens, turkeys, ducks and geese (for example, feeding meat, milk, butter, eggs, fur, leather, feathers and/or wool). By confronting Biology can reduce the rate of death and productivity (in meat, milk, wool, skin, eggs, etc.). Thus, as long as the compound of the present invention is used, it is easier and more economical in animal husbandry.

The compounds of the present invention are useful for combating companion animals and pets (eg, cats, dogs, pet birds, and ornamental fish), research and experimental animals (such as hamsters, guinea pigs, voles and house mice), as well as zoos, wild habitats, and / or circus breeding animals.

In a particular embodiment of the invention, the animal is preferably a vertebrate, more preferably a mammal, bird or fish. In a particular embodiment, the animal individual is a mammal (including apes such as humans). Other mammalian individuals include primates (such as monkeys), cattle (such as cattle or cows), pigs (such as pigs or pigs), sheep (such as goats or sheep), horses (such as horses), and dogs. (eg dogs), cats (eg domestic cats), camels, deer, lynxes, buffaloes, antelopes, rabbits and rodents (eg guinea pigs, squirrels, voles, house mice, gerbils and hamsters). Birds include ducks (swan, ducks and geese), pigeons (eg pigeons), cockroaches (eg hawthorn, grouse and turkey), Thesienidae (eg chickens), parrots (eg long-tailed parrots, macaws) With parrots, hunting birds and flat-chested birds (such as ostriches).

Birds treated or protected by the compounds of the invention can also be birds associated with commercial or non-commercial bird breeding activities. These include ducks such as swans, geese and ducks; pigeons such as pigeons and domestic pigeons; cockroaches such as hawthorn, grouse and turkey; Thesienidae, such as domestic chickens; and parrots, for example for pets or Long-tailed parrots, macaws and parrots and the like that are kept for collection.

For the purposes of the present invention, the term "fish" is to be understood to include, but is not limited to, the Teleosti species, that is, the bony fish. Both the scorpion (which also includes the scorpion) and the scorpion (which also includes the scorpionfish) are included in the Teleosti class. Possible fish recipients include the genus Polygonaceae, Polygonaceae, Polygonaceae, Cichlidae, Sunfish and the like.

Other animals that can benefit from the invented method, including marsupials (such as kangaroos), reptiles (such as turtles), and other livestock with important economic value, have been carefully considered, and the method of invention is safe and effective. The problem of treating or preventing parasitic infections or infestation for these animals.

Examples of parasitic invertebrate pests that are controlled by providing a pesticidally effective amount of a compound of the invention to an animal to be protected include: ectoparasites (arthropods, ticks, etc.) and endoparasites (worms, eg, Nematodes, trematodes, mites, parasitic echinoderms, etc.).

The reason why a disease or a group of diseases that are usually described as helminthiasis is caused is because the animal host is infected with a parasite called a worm. The meaning of the term "worm" includes nematodes, flukes, mites, and parasitic echinococcosis. Worm disease poses a widespread and serious economic problem between livestock (such as pigs, sheep, horses, cattle, goats, dogs, cats and poultry).

Among the worms, a group of parasites described as nematodes are widely distributed, sometimes causing serious infection problems among many species of animals.

If considered carefully, the compounds of the present invention are intended to be used against the nematodes, including but not limited to the following genera: Acanthocheilonema , Aelurostrongylus , Ancylostoma , Angiostrongylus , chicken roundworms (Ascaridia), roundworm (Ascaris), Bruce mercerizing worm (Brugia), ruminants hookworms (Bunostomum), capillariasis (Capillaria), Shadbolt nematodes (Chabertia), Cooper nematode (Cooperia), ring Nematodes ( Cernosoma ), Dictyocaulus , Dioctophyme , Dipetalonema , Diphyllobothrium , Heartworm (Dirofilaria), Long line genus (Dracunculus), pinworms (Enterobius), filarial class (Filaroides), Haemonchus (Haemonchus), Heterakis genus (Heterakis), roundworm lip (Lagochilascaris), L. loa ( Loa ), Mansonella , Muellerius , Necator , Nematodirus , Oesophagostomum , Ostertagia , Nematodes ( Oxyuris ), Parafilaria , Parascaris , Physaloptera , Protostrongylus , Setaria , Spirocerca , and Stephanofilaria ), fecal nematode (Strongyloides), nematodes (Strongylus), sucking nematodes (Thelazia), bow roundworm C. elegans (Toxascaris), bow roundworm (Toxocara), Trichinella spiralis (Trichinella), wool genus (Trichonema), hair nematodes ( Trichostrongylus ), Trichuris , Uncinaria , and Wuchereria .

Above the most common zoonotic nematode genera Haemonchus (Haemonchus), hair round worm (Trichostrongylus), stomach nematodes (Ostertagia), narrow neck and nematodes (Nematodirus), Cooper nematode (Cooperia), roundworm (Ascaris), ruminants Bunostomum , Oesophagostomum , Chabertia , Trichuris , Strongylus , Trichonema , Dictyocaulus , Capillary nematode ( Capillaria ), Heterakis , Toxocara , Ascaridia , Oxyuris , Ancylostoma , Uncinaria , Toxascaris and Parasitic Locust ( Parascaris ). Wherein some of such Nematodirus (Nematodirus), Cooper nematode (Cooperia) with the toothed Oesophagostomum (Oesophagostomum) portion of the main attack the intestinal tract while others, such as Haemonchus (Haemonchus) and Ostertagia (Ostertagia) It is more common in the stomach, while others such as Dictyocaulus and the like appear in the lungs. There are other parasites that can be found in other tissues, such as heart and blood vessels, subcutaneous and lymphoid tissues, and the like.

If carefully considered, the invention and the method of the invention are intended to combat trematode, including but not limited to the following genus: Alaria , Fasciola , Nanophyetus , and trematode (Opisthorchis), Paragonimus (Paragonimus) and schistosomes (Schistosoma).

If considered carefully, the present invention and the method of the invention are intended to deal with aphids , including but not limited to the following genera: Diphyllobothrium , Diplydium , Spirometra and aphids ( Taenia ).

The most common parasitic genus in the human gastrointestinal tract is

Hookworms (Ancylostoma), spinigerum plate (Necator), roundworm (Ascaris), Strongy hides, Trichinella spiralis (Trichinella), capillariasis (Capillaria), whipworms (Trichuris) with pinworms (Enterobius). Other parasitic genus of blood or other tissues and organs found to be of great medical value outside the gastrointestinal tract, such as Wuchereria , Brugia , Onchocerca , and intestinal worms L. loa (Loa), and Long line genus (dracunculus) and parenteral stage - the fecal nematode (Strongyloides) and Trichinella spiralis (Trichinella).

Several other genus genus and species are known to those skilled in the art, and it is also necessary to carefully consider the compounds of the present invention to deal with them. These are all very detailed in the "Textbook of Veterinary Clinical Parasitology" (Editor: EJLSoulsby, published by FADavis Co., Philadelphia, PA), Volume 1, "Helminths" (Worms) Partial; "Helminths, Arthropods, & Protozoa" (worms, arthropods and protozoa in livestock) (Monnig's Veterinary Helminthology and Entomology) (6th edition of Monnig's Veterinary Wormology and Entomology). EJLSoulsby, published by Williams and Wilkins Co., Baltimore, Maryland).

The compounds of the invention are also effective against several animal ectoparasites (e.g., arthropod ectoparasites of mammals and birds).

Examples of insects and mites pests include biting insects (such as flies and mosquitoes), mites, ticks, scorpions, fleas, mites, parasitic mites, and the like.

Examples of adult fly flies include Haematobia irritans , Tabanus spp., Stomoxys calcitrans , Simulium spp., Chrysops spp., Melophagus ovinus ) There is also the Glossina spp. Examples of parasitic maggots include the fly ( Oestrus ovis and Cuterebra spp.), the fly (or Phaenicia spp.), the mollusk ( Cochliomyia hominivorax ), the larvae ( Hypoderma spp.), the woolworm and the horse. Gastrophilus . Examples of mosquitoes include Culex spp., Anopheles spp., and Aedes spp.

螨 includes Mesostigmalphatalpha spp., such as mesostigmatids , such as Dermalphanyssus galphallinalphae ; itch or sputum , such as Sarcoptidae spp., with Salpharcoptes scalphabiei as an example; 疥螨, like itch ( Psoroptidae spp), including bovine foot mites (Chorioptes bovis) and sheep itch mite (Psoroptes ovis);.. chiggers, for example TROMBICULIDAE (Trombiculidae spp), North American chiggers Ah's really chiggers (Trombicula alfreddugesi) is example.

Examples of ticks include soft palate , including Argasidae spp., Argalphas spp. and Ornithodoros spp.; hard palate , including Ixodidae spp. Rhipicephalphalus sanguineus , Dermacentor variabilis , Dermacentor andersoni , Amblyomma americanum , Ixodes scapularis , and other Rhipicephalus spp. example. (including the previous genus Boophilus ).

Examples of scorpions include sucking, like the genus Menopon spp.

And Bovicola spp.; biting, such as Haematopinus spp., Linognathus spp. and Solenopotes spp.

Examples of fleas include Ctenocephalides spp., such as Ctenocephalides canis and Ctenocephalides felis ; Xenopsylla spp., such as Xenopsylla cheopis ; Pulex spp., such as Pulex irritans .

Examples of artifacts include Cimicidae or, for example, the common temperate bed bug ( Cimex lectularius ); Triatominae spp., including the common genus known as the kissing worm, Rhodnius prolixus Take the example of Triatoma spp.

In general, flies, fleas, scorpions, mosquitoes, crickets, crickets, ticks and worms can cause huge losses to the livestock industry and the companion animal industry. Arthropod parasites also cause problems for humans and become vectors for pathogenic organisms of humans and animals.

Several other parasitic invertebrate pests are known to those skilled in the art, and the compounds of the present invention need to be carefully considered to deal with them. These are all detailed in the Medical and Veterinary Entomology (editor: DSKettle, published by John Wiley AND Sons in New York and Toronto); Control of Arthropod Pests of Livestock: A Review of Technology (Technical Review: Animal Arthropod Pest Control) (Editors: RODrummand, JEGeorge and SEKunz, published by CRC Press, Inc., Boca Raton, FL).

The invention also provides methods of controlling pests (e.g., mosquitoes and other disease vectors; additional reference may be made to http://www.who.int/malaria/vector_control/irs/en/). in a In a specific example, the method of controlling a pest comprises applying the composition of the present invention to a target pest, where it is located, the surface of the object, or a substrate by brushing, rolling, spraying, spreading or immersing. For example, for applying an indoor residual spray (IRS) to an object (such as a wall, ceiling or floor) surface, the method of the present invention has been carefully considered for this purpose. In another embodiment, such compositions may also be applied to a substrate, such as in the form of mesh products, clothing, bedding, curtains, and tents (or may be used to make these products), depending on careful considerations. Or cloth material.

In one embodiment, a method of controlling such pests comprises applying a pesticidally effective amount of a composition of the invention to a target pest, where it is located, on a surface or substrate of the object, on a surface or Provides effective residual insecticidal activity on the substrate. Such applications can be carried out by brushing, rolling, spraying, spreading or dipping into the insecticidal compositions of the present invention. For example, for applying an indoor residual spray (IRS) to an object (such as a wall, ceiling or floor) surface, the method of the present invention has been carefully considered for such use to provide effective residual pesticidal activity on the surface. In another embodiment, such a composition may also be applied to a substrate, such as in the form of a web product, clothing, bedding, curtains, and tents (or may be used to make these products), depending on careful considerations. Material to control residual pests.

The substrate to be treated (including non-woven fabrics, cloth or net products) can be made of natural fibers such as cotton, raffia, jute, linen, sisal, burlap, wool, or synthetic fibers such as polyamide or polyester. , polypropylene, polyacrylonitrile and the like. Polyester is particularly suitable. The processing method of the fabric is known from the following sources, such as "Handbuch Textilveredlung: Band 1: Ausrü Stung, Band 2: Farbgebung, Band 3: Beschichtung, Band 4: Umwelttechnik (Vol. 1: Equipment, Volume 2: Color, Volume 3: Coatings, Volume 4: Environmental Technology); Publisher: Deutscher Fachverlag ;Version: 15.; Revised: April 17, 2006; ISBN-10: 3866410123; ISBN-13: 978-3866410121, see, in particular, Band 1: Ausrütung (Vol. 1: Equipment), pp. 27-198. In particular, page 118; or WO2008151984, WO2003034823, US5631072, WO200564072, WO2006128870, EP1724392, WO2005064072, WO2005113886 or WO2007090739.

The compounds of the invention may also be effective against ectoparasites, including, for example, Haematobia (Lyperosia) irritans , Simulium spp., Glossina spp., Hydrotaea irritans , Musca autumnalis , Musca domestica , Morellia simplex , Tabanus spp., Hypoderma bovis , Hypoderma lineatum , Lucilia Sericata ), Lucilia cuprina , Calliphora spp., Protophormia spp., Oestrus ovis , Culicoides spp., horsefly ( Hippobosca equine ), Gastrophilus intestinalis , Gastrophilus haemorrhoidalis and Gastrophilus nasalis ; such as Bovicola (Damalinia bovis ), Bovicola equi , 驴 Hazeltopinus asini , Felicola subrostratus , Heterodoxus spiniger , Lignonathus setosus , and Trichodectes canis ; Such as flies such as Melophagus ovinus , and such as Psoroptes spp., Sarcoptes scabei , Chorioptes bovis , Demodex equi , and Alfalfa Species such as Cheyletiella spp., Notoedres cati , Trombicula spp. and Otodectes cyanotis .

The treatment of the present invention is by enteral administration in the form of a conventional therapy, for example, in the form of a tablet, a capsule, a syrup, a drug, a granule, an ointment, a pill, a medicinal herb, or a suppository; or by, for example, Non-oral administration or injection filling methods such as intramuscular injection, subcutaneous injection, intravenous injection, intraperitoneal injection; or intranasal administration.

When the additional biologically active ingredient is administered in combination with a compound of the invention, it can be administered individually, for example as an individual composition. In this case, the biologically active ingredients may be administered simultaneously or sequentially. Alternatively, the bioactive ingredient can also be used as a constituent of a composition.

The compounds of the invention are administered in a controlled release form, for example in a slow release form for subcutaneous or oral administration.

In general, the pesticidal composition according to the invention comprises a compound of the invention which can be optionally combined with an additional biologically active ingredient, or an N-oxide or a salt thereof, and with the desired administration. One or more pharmaceutically or veterinary acceptable carriers (e.g., for oral administration or parenteral administration such as injection) of the excipients and adjuvants selected in connection with the route are consistent with standard practice. In addition, a suitable carrier is selected based on considerations such as compatibility with one or more active ingredients in the composition, including stability in relation to pH and water content, and the like. Therefore, the present invention It is worth noting that the compound protects the animal from parasitic invertebrate pests, comprising a parasiticidally effective amount of a compound of the invention, and optionally combining an additional bioactive ingredient, and at least one carrier.

For parenteral administration including intravenous, intramuscular, subcutaneous injection and the like, the compound of the present invention can be formulated as a suspension, a solvent or an emulsion in an oily or aqueous vehicle, and can contain a suspending agent and be stable. Additives for agents and/or dispersants and the like.

The compounds of the invention can also be formulated for either single injection or continuous intravenous drip. The pharmaceutical ingredient to be injected comprises an aqueous solution (for example, an active compound salt) in a water-soluble form of the active ingredient, preferably a physiologically compatible buffer containing other excipients or adjuvants, which is well known. Medical formula tips. In addition, suspensions of the active compounds can be prepared with lipophilic vehicles. Suitable lipophilic vehicles include fatty oils such as sesame oil, or synthetic fatty acid esters of ethyl oleate and triglycerides, or materials such as liposomes and the like.

Aqueous injection suspensions may contain materials which increase the viscosity of the suspension, such as sodium carboxymethylcellulose, sorbitol, or dextran. The formulation of the injectable solution may be presented in unit dosage form, for example, in an ampoule or in a multi-dose container. Alternatively, prior to use, the active ingredient may be in powder form for combination with a suitable vehicle, for example, sterile non-pyrogenic water.

In addition to the formulations described above, the compounds of the invention may also be formulated in the form of a depot preparation. Such long-acting formulations may be administered in a manner Injection (eg, subcutaneous or intramuscular) or intramuscular or subcutaneous injection.

The compounds of the present invention can be formulated for this route of administration, with suitable polymeric materials or hydrophobic materials (for example, in emulsions containing pharmaceutically acceptable oils and fats), or with ion exchange resins, or as A slightly soluble derivative such as, but not limited to, a sparingly soluble salt or the like.

For inhaled administration, the compounds of the invention may utilize a pressurized pack or nebulizer, as well as suitable propellants (such as, but not limited to, dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane or It is carbon dioxide) and is delivered as a spray. In the case of a pressurized aerosol, the dosage unit can be controlled by providing a stopcock to deliver a metered volume.

For example, gel capsules and cartridges for use in an inhaler or insufflator can be formulated with a powder mixture containing a compound and a suitable foundation such as lactose or starch.

The compounds of the invention may have good pharmacokinetic and pharmaceutical efficacy properties, providing systemic availability from oral administration and ingestion. Thus, upon ingestion of the animal to be protected, the compound of the invention, when in the bloodstream reaches an effective concentration of parasiticidal, protects the treated animal from blood-sucking such as fleas, ticks and lice. Biological bites. Therefore, it is worth noting that the composition for protecting the animal from the invertebrate parasitic pest by oral administration (ie, in addition to the compound of the present invention containing an effective concentration of the parasiticidal, further comprises one or more selected from suitable Oral administration to a carrier or a carrier for feeding a concentrate carrier).

For solvents (the most usable form of absorption), emulsions, suspensions, medicines Oral administration in the form of a cream, a gel, a capsule, a tablet, a bolus, a powder, a granule, a rumen retention, and a feed/water/clam block, etc., can be suitably formulated for oral administration in the art. Binders/fillers such as sugars and sugar derivatives (eg lactose, sucrose, mannitol, sorbitol), starch (eg corn starch, wheat starch, rice starch, potato starch), cellulose and derivatives ( For example, methyl cellulose, carboxymethyl cellulose, hydroxy fiber), protein derivatives (such as maize protein, gelatin), and synthetic polymers (such as polyvinyl alcohol, polyvinylpyrrolidone) and the like. If necessary, a lubricating oil (for example, magnesium stearate), a disintegrating agent (for example, crosslinked polyvinylpyrrolidone, agar, alginic acid), and a dye or pigment may be added. Ointments and gels often also contain binders (eg, artichoke, alginic acid, bentonite, cellulose, xanthan gum, colloidal aluminum magnesium citrate) to help keep the composition in contact with the oral cavity and are not easily ejected.

In a specific example, the compositions of the present invention are formulated into chewable and/or edible products (e.g., chewable therapeutic foods or edible tablets). Ideally, protected animals will appreciate the taste, texture and/or aroma of such products, and will more readily take the compounds of the present invention.

If the form of the parasiticidal composition is a concentrated feed, the carrier is generally selected from high-efficiency feeds, feed grains or concentrated proteins.

In addition to the parasiticidally active ingredient, such concentrated feed compositions can also contain additives that promote the health or growth of the animal, increase the meat quality of the slaughtered animal, or are useful for the livestock industry.

These additives may include, for example, vitamins, antibiotics, chemotherapy, bacteriostats, mold growth inhibitors, coccidiostats, and hormones.

It is also possible to use a conventional suppository base such as cocoa butter or other glycerides. The compounds of the invention are formulated in rectal compositions such as suppositories or retention enemas and the like.

Formulations of the methods used in the present invention may include an antioxidant such as BHT (dibutylhydroxytoluene). The dose of the antioxidant is generally from 0.1 to 5% (wt/vol). Some formulations require a solubilizing agent, such as oleic acid, to solubilize the active agent, especially if spinosyn is included. These pour-on formulations used in the composition of common spreading agents include isopropyl myristate, isopropyl palmitate, C ₁₂ -C ₁₈ saturated fatty alcohols caprylic / capric acid esters, oleic acid, oleyl oleate, Ethyl ester, triglyceride, eucalyptus oil and dipropylene glycol methyl ether. The pour-on formulations of the methods used in the present invention are prepared according to known techniques. When the method of pouring is used as a solution, the insect repellent/insecticide is mixed with a carrier or a vehicle, and if necessary, it may be mixed by heat and stirring. The auxiliary ingredients or additional ingredients may be added to the mixture of the active agent and the carrier, or they may be first mixed with the active agent before the carrier is added. Pour-on formulations in the form of emulsions or suspensions are also prepared analogously using known techniques.

Other delivery systems that are relatively hydrophobic drug compounds can be employed. Liposomes and emulsions are well known examples of hydrophobic drug delivery vehicles or carriers. In addition, an organic solvent such as dimethyl hydrazine can also be used if necessary.

How much proportion should be applied to effectively control parasitic invertebrate pests (such as "killing pest effective amount"), depending on various factors, such as the type of parasitic invertebrate pest to be controlled, the life cycle of the pest, and the life stage , its size, location, time of year, host crop or animal, feeding behavior, mating behavior, environmental humidity, temperature, etc. Skilled people can easily determine how much pesticidal effective amount is needed to achieve the desired parasitic invertebrate pest control.

In general, in veterinary use, the compounds of the invention are provided in a pesticidally effective amount to render the animal (especially warm-blooded animals) infested by parasitic invertebrate pests.

The pesticidal effective amount refers to the amount of active ingredient required to achieve a significant effect to reduce the incidence or activity of the target parasitic invertebrate pest. Skilled people will understand that the effective amount of pesticidal agents will vary depending on a variety of factors, such as the various compounds and compositions useful for the methods of the invention, the desired insecticidal effect and duration, and the parasitic invertebrate of the target. Species of pests, protected animals, patterns of application, etc., and the amount required to achieve a particular result can be determined by simple experimentation.

For oral or parenteral administration of the animal, the dose of the composition of the present invention administered at an appropriate time is generally from about 0.01 mg/kg to about 100 mg/kg, and preferably 0.01 mg of the animal's body weight. / kg or so to 30 mg / kg or so.

The appropriate interval for supplying the compositions of the present invention to animals is from about daily to about yearly. It is worth noting that this dosing interval is from about every week to about every other month, and that the monthly dosing interval (that is, once a month for the animal to supply the compound) is particularly noteworthy.

The invention also provides methods of controlling pests (e.g., mosquitoes and other disease vectors). In one embodiment, the method of controlling a pest comprises applying the composition of the present invention to a target pest, where it is located, the surface of the object, or by brushing, rolling, spraying, spreading or immersing. On the substrate. For example, for applying an indoor residual spray (IRS) to an object (such as a wall, ceiling or floor) surface, the method of the present invention has been carefully considered for this purpose. In another embodiment, such compositions may also be applied to a substrate, such as in the form of mesh products, clothing, bedding, curtains, and tents (or may be used to make these products), depending on careful considerations. Or cloth material.

In one embodiment, a method of controlling such pests comprises applying a pesticidally effective amount of a composition of the invention to a target pest, where it is located, on a surface or substrate of the object, on a surface or substrate. Provides effective residual pesticidal activity. Such applications can be carried out by brushing, rolling, spraying, spreading or immersing in the pesticidal composition of the present invention. For example, for applying an indoor residual spray (IRS) to an object (such as a wall, ceiling or floor) surface, the method of the present invention has been carefully considered for such use to provide effective residual pesticidal activity on the surface. In another embodiment, such a composition may also be applied to a substrate, such as in the form of a web product, clothing, bedding, curtains, and tents (or may be used to make these products), depending on careful considerations. Material to control residual pests.

The substrate to be treated (including non-woven fabrics, cloth or net products) can be made of natural fibers such as cotton, raffia, jute, linen, sisal, burlap, wool, or synthetic fibers such as polyamide or polyester. , polypropylene, polyacrylonitrile and so on. Polyester is particularly suitable. The processing method of the fabric is known from the following sources, such as "Handbuch Textilveredlung: Band 1: Ausrütung, Band 2: Farbgebung, Band 3: Beschichtung, Band 4: Umwelttechnik" (Volume 1: Equipment, Volume 2: Color, Volume 3: Coatings, Volume 4: Environmental Technology); Publisher: Deutscher Fachverlag; Version: 15.; Revision: April 17, 2006; ISBN -10:3866410123; ISBN-13: 978-3866410121, in particular, see Band 1: Ausr ung (Vol. 1: Equipment) on pages 27-198, especially page 118; or WO2008151984, WO2003034823, US5631072, WO200564072, WO2006128870, EP1724392, WO2005064072, WO2005113886 or WO2007090739.

The term "plant" as used herein includes seedlings, shrubs and trees.

The term "crop" should be understood to also include crop plants that are transformed using recombinant DNA techniques and converted to be capable of synthesizing one or more selectively acting toxins, for example from bacteria-producing bacteria. Toxins (especially bacteria belonging to the genus Neisseria).

For example, toxins that can be released from these genetically transgenic plants include insecticidal proteins from Bacillus cereus or emulsified bacteria; or insecticidal proteins from Bacillus thuringiensis (such as delta-endotoxin), such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C; or a vegetative insecticidal protein (VIP) such as VIP1, VIP2, VIP3 or Vip3A; or a bacterial-borne nematode (such as a luminescent photobacterium) Photoinhabdus luminescens), insecticidal proteins of Photorhabdus spp. or Xenorhabdusspp., such as Xenorhabdus nematophilus; toxins made from animals, such as scorpion toxin, arachnid Animal toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomyces Toxin; plant lectin, such as pea lectin, barley lectin or snowdrop lectin; white peony extract lectin; protease inhibitors such as trypsin inhibitor, serine protease inhibitor, patatin, cystatin, Papain inhibitor; ribosome inactivating protein (RIP), such as ricin, corn-RIP, acacia, loofah, saporin or diarrhea protein; steroid metabolism enzymes such as 3-hydroxyl Steroid oxidase, ecdysone UDP glycosyltransferase, cholesterol oxidase, ecdysone inhibitor, HMG-COA reductase, ion channel blocker, such as sodium or calcium channel, juvenile hormone esterase, diuretic hormone receptor, two Styryl synthase, biphenyl methyl synthase, chitinase and glucanase blockers.

In the present invention, some portions are to be understood as delta-endotoxins, such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or nutritive insecticidal proteins (VIP), such as Vip1, Vip2, Vip3 or Vip3A, especially mixed toxins, truncated toxins and engineered toxins. Hybrid toxins are produced in a recombination manner by a new combination of different domains of these proteins (see, for example, WO02/15701). Truncated toxins are known, such as the truncated Cry1Ab. In the modification of toxins, one or more amino acids of naturally occurring toxins are replaced. In the case of such amino acid substitution, it is preferred to insert a non-naturally occurring protease recognition sequence into the toxin. For example, as in the case of Cry3A055, a cathepsin-G-recognition sequence is inserted into the Cry3A toxin (see WO 03/018810).

It has been disclosed in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073, etc. Examples of toxins or gene transfer plants of toxins.

The preparation of such genetically transformed plants is generally known to those skilled in the art, and these processes have been described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acid and its preparation are known from WO 95/34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651.

Toxins contained in genetically transformed plants impart tolerance to harmful insects to plants. This insect can occur in any insect taxonomic group, but is often classified as a beetle (Coleoptera), a double-winged worm (Diptera), and a butterfly (Lepidoptera).

Gene-transgenic plants that have one or more genes that encode insecticidal resistance and release one or more toxins are not only known, but some of them are commercially available. Examples of such plants are: YieldGard® (a corn variety that releases Cry1Ab toxin); YieldGard Rootworm® (a corn variety that releases Cry3Bb1 toxin); YieldGard Plus® (a corn variety that releases Cry1Ab and Cry3Bb1 toxin); Starlink® ( Released Cry9C toxin maize variety); Herculex I® (released Cry1Fa2 toxin and glufosinate N-acetyltransferase enzyme (PAT) to chlorhexidine herbicide tolerance maize variety); NuCOTN 33B® ( Cotton varieties that release Cry1Ac toxin); Bollgard I® (cotton varieties that release Cry1Ac toxin); Bollgard II® (cotton varieties that release Cry1Ac and Cry2Ab toxins); VipCot® (cotton varieties that release Vip3A and Cry1Ab toxins) NewLeaf® (released Cry3A toxin potato variety); NatureGard®, Agrisure® GT Advantage (G21 glyphosate tolerance), Agrisure® CB Advantage (Bt11 corn borer (CB) characteristics) and Protecta®.

More examples of such genetically modified crops are:

1. Bt11 corn (from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France; registration number: C/FR/96/05/10). The genetically engineered Zea mays corn has been able to resist the invasion of the European corn borer ( Serrinia nubilalis and Sesamia nonagrioides ) by releasing the truncated Cry1Ab toxin by gene transfer. Bt11 corn also releases PAT enzyme by gene transfer to achieve tolerance to glufosinate herbicides.

2. Bt176 corn (from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France; registration number: C/FR/96/05/10). The genetically engineered Zea mays corn has been able to resist the invasion of the European corn borer ( Serrinia nubilalis and Sesamia nonagrioides ) by releasing the Cry1Ab toxin by gene transfer. Bt176 corn also releases PAT enzyme by gene transfer to achieve tolerance to glufosinate herbicides.

3. MIR604 corn (from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France, registration number: C/FR/96/05/10). This corn has been able to resist insect damage by releasing the engineered Cry3A toxin by gene transfer. This toxin is a Cry3A055 engineered by insertion of a cathepsin-G protease recognition sequence. Information on the preparation of such genetically transformed maize plants is described in WO 03/018810.

4. MON 863 corn (from Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number: C/DE/02/9). MON 863 releases the Cry3Bb1 toxin and is resistant to certain coleopteran insects.

5. IPC 531 cotton (from Monsanto Europe SA, 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number: C/ES/96/02).

6. 1507 Corn (from Pioneer Overseas Corporation, Address: Avenue Tedesco, 7 B-1160 Brussels, Belgium, registration number: C/NL/00/10). This genetically engineered maize is designed to release the Cry1F protein to achieve tolerance to certain lepidopteran insects and to express PAT proteins to achieve tolerance to glufosinate herbicides.

7. NK603 x MON 810 corn (from Monsanto Europe SA, address: 270-272 Avenue de Tervuren, B 1150 Brussels, Belgium, registration number: C/GB/02/M3/03). This maize includes hybrid corn varieties that have been conventionally developed by hybridizing genetically engineered NK603 and MON810. NK603×MON 810 maize released the protein CP4 EPSPS obtained from the Agrobacterium spp. CP4 strain by gene transfer, which confers on Roundup® herbicide (containing glyphosate). Tolerance, and expression of the Cry1Ab toxin obtained from Bacillus thuringiensis subsp . kurstaki , which confers tolerance to certain lepidopteran organisms, including European corn borers. The so-called crops can also be those that have been resistant to pests by genetic engineering techniques, including Bt corn (which is resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and Bt potato ( Resistant to Colorado beetles). An example of Bt corn is the NK brand Bt 176 Corn Mix (Syngenta Seeds). Examples of genetically modified plants are KnockOut® (corn), Yield Gard® (corn), NuCOTIN 33B® (cotton), Bollgard® (cotton), NewLeaf® (potato), NatureGard® and Protexcta, one or more of these plants. The genes encode insecticidal resistance and release one or more toxicities.

Plant crops or their seed materials are resistant to both herbicides and insect foraging (stacked gene transfer events). For example, seeds can release a pesticidal Cry3 protein while being tolerant to glyphosate.

Crops should also be understood as crops obtained by conventional breeding methods or genetic engineering techniques, as well as crops containing so-called export traits such as better storage stability, higher nutritional value and better taste. .

In order to use a compound of formula (I) as an insecticide, acaricide, nematicidal or molluscicide for application to a pest, where it is or susceptible to pests, formula (I) will generally be used. The compounds are formulated into a composition incorporating the compound of formula (I) itself, together with a suitable inert diluent or carrier, and optionally incorporating a surfactant (SFA). SFA, a chemical that reduces interfacial tension and thereby induces changes in other properties (such as dispersibility, emulsifying, and wet) to alter an interface (such as liquid/solid, liquid/air or liquid/liquid surfaces) Characteristics. All compositions (solid and liquid formulations) preferably comprise (by weight) from 0.0001 to 95%, more preferably from 1 to 85%, for example from 5 to 60%, of the compound of formula (I). The composition is generally used for controlling pests, and the application rate of the compound of the formula (I) is from 0.1 to 10 kg per hectare, preferably from 1 to 6 kg per hectare, more preferably from 1 to 1 kg per hectare.

If used in seed dressing, the application rate of the compound of formula (I) is generally from 0.0001 g to 10 g (e.g., 0.001 g or 0.05 g) per kg of seed, preferably from 0.005 g to 10 g, more preferably 0.005. Gram to 4 grams.

Another aspect of the invention provides a composition comprising a pesticidally effective amount of a compound of formula (I), especially an insectic, acaricidal, nematicidally or molluscicidal effective amount of a compound of formula (I) and suitable A carrier or diluent for the composition of insecticidal, acaricidal, nematicidal or molluscicidal animals. Preferably, the composition is a pesticidal, acaricidal, nematicidal or molluscicidal composition.

The composition can be selected from a number of formulation types including powder (DP), soluble powder (SP), water soluble granules (SG), water dispersible granules (WG), wettable powders (WP), granules. Agent (GR) (slow or rapid release), soluble concentrate (SL), oil soluble liquid (OL), ultra low volume liquid (UL), emulsified concentrate (EC), dispersible concentrate (DC), Emulsions (oil-in-water (EW) and water-in-oil (EO)), microemulsions (ME), suspension concentrates (SC), aerosols, atomization/smoke formulations, capsule suspensions (CS) and seed treatment Formulation. The type of formulation selected in any of the examples will depend on the particular intended purpose, as well as the physical, chemical, and biological properties of the compound of formula (I).

A powder (DP) can be prepared by reacting a compound of formula (I) with one or more solid diluents (eg, natural clay, kaolin, pyrophyllite, bentonite, alumina, montmorillonite, diatomaceous earth, chalk). Mixing diatomaceous earth, calcium phosphate, calcium carbonate, magnesium carbonate, sulfur, lime, flour, talc and other organic and inorganic solid carriers, and mechanically grinding the mixture into a fine powder.

By reacting a compound of formula (I) with one or more water-soluble inorganic salts (for example, sodium bicarbonate, sodium carbonate or magnesium sulfate), or mixed with one or more water-soluble organic solids (such as polysaccharides), and optionally mixed with one or more wetting agents, dispersed with one or more The soluble powder (SP) is prepared by mixing or mixing with a mixture of a wetting agent and a dispersing agent to improve water dispersibility/solubility. This mixture is then ground to a fine powder. Similar compositions can also be granulated to form water soluble granules (SG).

By promoting the compound of formula (I) with one or more solid diluents or carriers, one or more wetting agents (and preferably one or more dispersing agents), and optionally one or more suspensions to facilitate in the liquid Dispersion to prepare wettable powder (WP). This mixture is then ground to a fine powder. Similar compositions can also be granulated to form a water dispersible granule (WG).

Granulation (GR) can be formed in two ways: by granulating a mixture of a compound of formula (I) with one or more powdered solid diluents or carriers, or from preformed blank particles (by means of porous particulate material) Absorbing a compound of formula (I) (or a solvent thereof, which is absorbed in a suitable reagent) to form a granule (for example, in pumice, erbium, smectite, diatomaceous earth or ground corn cob); The compound of formula (I) (or its solvent, absorbed in a suitable reagent) is absorbed on a hard core material such as sand, citrate, mineral carbonate, sulfate or phosphate and dried if necessary. Reagents commonly used to aid absorption or absorption, including solvents (eg, aliphatic and aromatic petroleum solvents, alcohols, ethers, ketones, and esters) and adhesives (eg, polyvinyl acetate, polyvinyl alcohol, dextrin, sugar, and vegetable oils) ). One or more other additives (such as emulsifiers, wetting agents or dispersing agents) may also be included in the granules.

The compound of formula (I) can be dissolved in water or an organic solvent (such as a ketone, an alcohol or A glycol ether) is used to prepare a dispersible concentrate (DC). These solutions may contain surfactants (for example to improve water dilution or to prevent crystallization in a spray can).

An emulsified concentrate (EC) or an oil-in-water emulsion can be prepared by dissolving a compound of formula (I) in an organic solvent, optionally comprising one or more wetting agents, one or more emulsifiers or a mixture of the foregoing. (EW). Organic solvents suitable for use in EC include aromatic hydrocarbons (e.g., alkylbenzenes or alkylnaphthalenes, exemplified in SOLVESSO 100, SOLVESSO 150, and SOLVESSO 200; SOLVESSO is a registered trademark), ketones (e.g., cyclohexanone or methylcyclohexanone). And alcohols (such as benzyl alcohol, decyl or butanol), N -alkylpyrrolidone (such as N -methylpyrrolidone or N -octylpyrrolidone), fatty acid dimethyl decylamine (such as C ₈ -C ₁₀ fatty acid dimethyl decylamine) and chlorocarbons. Once the EC product is added with water, it is naturally emulsified to produce an emulsion with sufficient stability and can be sprayed by suitable equipment. Preparation of EW involves obtaining a compound of formula (I) in liquid form (if it is not liquid at ambient temperature, it may melt at a reasonable temperature, typically below 70 ° C), or in the form of a solution ( I) The compound (by dissolving it in a suitable solvent) and then emulsifying the resulting liquid or solution in water containing one or more SFAs under high shear to produce an emulsion. Suitable solvents for EWs include vegetable oils, chlorocarbons (such as chlorobenzene), aromatic solvents (such as alkylbenzenes or alkylnaphthalenes), and other suitable and water-soluble organic solvents.

Microemulsions (ME) can be prepared by naturally producing a thermally stable, isotropic liquid formulation by mixing water with one or more blends containing one or more SFAs. The initial form of the compound of formula (I) is water or Solvent/SFA blend. Solvents suitable for use in MEs include the solvents described above for ECs or EWs. The ME can be an oil-in-water or water-in-oil system (which can be determined by conductivity measurements to determine which system is present), and can also be adapted to mix water-soluble and oil-soluble pesticides in the same formulation. ME is suitable for dilution in water, including continuing to maintain the form of a microemulsion or forming a conventional oil-in-water emulsion.

The suspension concentrate (SC) may comprise an aqueous or non-aqueous suspension of finely insoluble solid particles of the compound of formula (I). The compound of formula (I) (optionally using one or more dispersing agents) can be milled in a suitable medium by ball milling or bead milling to prepare SC, whereby a suspension of the finely divided compound can be prepared. The composition may contain one or more wetting agents and a suspension may be added to reduce the rate of particle precipitation. Alternatively, the compound of formula (I) can be dry milled and added to water containing the aforementioned reagents to form the desired end product.

Aerosol formulations comprise a compound of formula (I) and a suitable propellant (e.g., n-butane). The compound of formula (I) may also be dissolved or dispersed in a suitable medium (e.g., water or a water soluble liquid such as n-propanol) to provide a composition for use in a non-pressurized hand-actuated spray pump.

The compound of formula (I) can be mixed with the pyrotechnic mixture in a dry state to form a composition suitable for producing a fumes containing the compound in a confined space.

The capsule suspension (CS) can be prepared in a similar manner to the preparation of the EW formulation, but with the addition of an additional polymerization stage whereby water dispersion of the oil droplets is obtained, wherein each oil droplet is encapsulated with a polymeric outer shell and contains a compound of formula (I), and optionally a carrier or diluent. Polymeric shell It is made by an interfacial polycondensation reaction or a coagulation procedure. The composition provides a controlled release effect of the compound of formula (I) and can be used for seed treatment. The compound of formula (I) can also be formulated in a biodegradable polymer matrix to provide a slow, controlled release of the compound.

One or more additives may be included in the composition to enhance the bio-exhibition of the composition (e.g., by improving wettability, retention or surface distribution; the rain resistance of the treated surface; or the uptake of the compound of formula (I) And mobility to improve). Such additives include surfactants, spray additives based on certain mineral oils or natural vegetable oils (such as soybean and rapeseed oil), and other bio-enhancing adjuvants that can help or modify compounds of formula (I). Blend of the component of action.

The compounds of formula (I) may also be formulated as seed treatment formulations, such as powder compositions, including powders for dry seed treatment (DS), water soluble powders (SS) or water dispersible powders for mud water treatment (WS). ), or a liquid composition, including a suspension concentrate (FS), a solvent (LS) or a capsule suspension (CS). The preparation methods of the DS, SS, WS, FS and LS compositions are very similar to the preparation methods of the above DP, SP, WP, SC and DC compositions, respectively. The composition for treating the seed may include an agent (e.g., mineral oil or film-forming barrier) for assisting in the attachment of the composition to the seed.

The humectant, dispersant and emulsifier can be cationic, anionic, amphoteric or nonionic surface SFA.

Suitable SFAs of the cationic type include quaternary ammonium compounds such as cetyltrimethylammonium bromide, imidazolines and amine salts.

Suitable anionic SFAs include alkali metal salts of fatty acids, lipids of sulfuric acid a salt of a monoester (for example, sodium lauryl sulfate), a salt of a sulfonated aromatic compound (for example, sodium dodecylbenzenesulfonate, calcium dodecylbenzenesulfonate, butylene naphthalenesulfonate, and two a mixture of sodium isopropyl naphthalene sulfonate and sodium triisopropyl naphthalene sulfonate), an ether sulfate, an alcohol ether sulfate (for example, sodium laureth-3 sulfate), an ether carboxylate (for example, a lauryl polyether) -3 sodium carboxylate), a phosphate ester (product of the reaction of one or more fatty alcohols with phosphoric acid (mainly monoester) or phosphorus pentoxide (mainly diester), such as lauryl alcohol and tetraphosphoric acid; These products may be ethoxylated), sulfonated amber phthalates, paraffin or olefin sulfonates, aminoethanesulfonates and lignosulfonates.

Suitable SFAs of the amphoteric type include betaines, propionates and glycinates.

Suitable SFAs of the nonionic type include condensation products of alkylene oxides such as ethylene oxide, propylene oxide, butylene oxide, or their association with fatty alcohols such as oleyl alcohol or cetyl alcohol or alkylphenols (eg a mixture of octylphenol, nonylphenol or octylcresol; a partial ester obtained from a long chain fatty acid or hexitol anhydride; a condensation product of the above partial ester with ethylene oxide; a block polymer (including an epoxy) Ethane and propylene oxide; alkanolamine; monoester (e.g., fatty acid polyethylene glycol ester); amine oxide (e.g., dodecyldimethylamine oxide); and lecithin.

Suitable suspending agents include hydrophilic colloids (such as polysaccharides, polyvinylpyrrolidone or sodium carboxymethylcellulose) and swelling clays (such as bentonite or attapulgite).

The compound of formula (I) can be administered using any known method of administering a pesticidal compound. For example, whether it is formulated or not, it can be applied directly to where pests or pests are located (eg pests) a habitat, or a growing plant that is susceptible to pests) or applied to any part of the plant, including leaves, stems, shoots or roots, or applied to the seed prior to planting the seed, or Growing plants, or other mediums in which plants are to be planted (such as soil around the roots, soil, rice fields, or hydroponic systems), or spray or sprinkle them in soil or in an aqueous environment. Applied in a soaking manner, applied as a cream or ointment formulation, applied as a vapor, or applied by dispensing or adding a composition (eg, a particulate composition or encapsulated in a water soluble pouch) Composition)).

The compounds of formula (I) may also be injected into plants or sprayed onto plants using electrodynamic spraying techniques or other minor methods, or applied using land or aerial irrigation systems.

Compositions for use as aqueous preparations (e.g., aqueous solutions or dispersions) are typically supplied as a concentrate containing a high proportion of active ingredient (the concentrate is added to the water prior to use). These concentrates, which can contain DCs, SCs, ECs, EWs, MEs, SGs, SPs, WPs, WGs, and CSs, are typically capable of withstanding long-term storage and can be added to form aqueous formulations after such long-term storage. And these agents can remain homogenous for a sufficient period of time for application by conventional spray equipment. Depending on the use, such aqueous preparations may contain varying amounts of the compound of formula (I) (for example from 0.0001 to 10% by weight).

The compound of formula (I) can be used in a mixture with a fertilizer such as a fertilizer containing nitrogen, potassium or phosphorus. Suitable formulation types include fertilizer granules. The content of the compound of the formula (I) in the mixture is preferably up to 25% by weight of the compound.

Accordingly, the present invention also provides a fertilizer composition comprising a fertilizer and a compound of formula (I). The compositions of the present invention may comprise other biologically active compounds, such as micronutrients or compounds having the following activity: fungicidal activity, or plant growth regulating, herbicidal, insecticidal, nematicidal or acaricidal activity.

A compound of formula I (hereinafter abbreviated by the term "TX", meaning a compound surrounded by a compound of formula I, or more preferably, the term "TX" is selected from Tables 1 to 12, A, The compound of B and C) may be the sole active ingredient of the composition, or it may be mixed with one or more additional active ingredients, such as pesticides (insects, mites, mollusks and nematodes, where appropriate). Insecticides), fungicides, synergists, herbicides, safeners or plant growth regulators, and the like. According to the invention, the activity of the composition can thus be greatly expanded and has surprising advantages (this can also be referred to broadly as synergistic activity). Additional active ingredients may: provide a composition with a broader spectrum of efficacy, or a more durable effect where the pest is, and provide a more plant/crop tolerant composition by reducing the phytotoxicity of the plant; Controls the composition of insects at different stages of development of insects; synergistically or complements the activity of TX (eg by increasing the rate of effect or by overcoming resistance); or assisting in overcoming or preventing the development of individual components Resistance. The particular additional active ingredient will depend on the intended utility of the composition. Examples of suitable pesticidal agents include the following: a) pyrethroid pesticides such as permethrin, cypermethrin, fenvalerate, S-fenvalerate, deltamethrin, cyhalothrin (especially Is cyhalothrin, bifenthrin, fenpropathrin, cyfluthrin, tefluthrin, fish safe pyrethroid pesticides (such as efenthrin), natural pyrethrins, methrin, s-bio Allylmethrin, fenfluralin, propargyl or 5-benzyl-3-furanmethyl-( E )-(1R,3S)-2,2-dimethyl-3-(2- Side oxythiophene -3-ylidenemethyl)cyclopropanecarboxylate; b) organophosphates such as bufson, thiopropylphosphonium, acesulfame, methyl-barlaxon, methyl tamarind, and chlorhexidine-s -Methyl, Fedasone, Methyl Disulfoxide, Penfensone, Azovin, Bufson, Sanluosong, Damasson, Dasongsong, Fusemisone, Marathon, Taosson, Yubisong, TOEFL Pine, Fanfusong, Dafusong, Furyson, Bassson, Yateson-methyl, ethylpyrimidine, chlorpheniramine, forsythia or russula; c) urethanes (including arylamines) Formate), for example, anti-carbocarb, zodicon, de-line, carbofuran, furosemide, insecticidal, dexamethasone, thiafuranone, butyl thiocarbamate, Insecticide, Zhongdingwei, propoxur, methomyl or chlorpyrifos; d) benzalazine, such as diflubenzuron, triflumuron, hexaflumuron, flubenzuron or chlorfenapyr; e) organotin compounds , for example, tricyclotin, phenbutyltin or triazole tin; f) pyrazoles, such as pyridoxamine and oxazolidine; g) macrolides, such as avermectin or mirabimycin, etc. For example, abatatin, indomethacin, ivermectin, milbemycin, or spinosyn, sinote or azadirachtin; h) hormone or pheromone; i) organochlorine compounds, Such as endosulfan, hexachlorobenzene, DDT, chlordane or dieldrin; j) terpenoids such as insecticidal or amitraz; k) fumigants such as trichloronitromethane, dichloropropane, methyl bromide or Weibaimu; l) neonicotinoids, such as edetamine, thiacloprid, acetamiprid, clothianidin, nitenpyram, dinotefuran or worm m) diarylmethionyl hydrazines, such as fenfenolone, cyclosporin or methoxypterin; n) diphenyl ethers, such as behenil or pyriproxy; o) indoxacarb; p) chlorfenapyr; q) pymetrozine or pyrifluquinazon; r) spirotetramat, spironolactone or spiromethyl ester; s) flufenamide, chlorhexidine or cyanamide; t) cyenopyrafen Or butaflurane; or u) flonicamidonitrile.

In addition to the primary chemical grade pesticides listed above, other pesticidal agents with specific objectives can be utilized in the composition if they are suitable for the intended composition. For example, selective insecticides suitable for a particular crop can be utilized, such as a locust-specific insecticide (such as Pedan) or a hopper-specific insecticide (such as chlorpyrifos) suitable for rice. Alternatively, insecticides or acaricides specific to a particular insect species/stage may also be incorporated into the composition (eg, mites and larvae, such as four mites). , fluorobenzimidazole, thiazolone or tetrachlorocrine, etc.; acaricides such as dicofol or ketone, etc.; acaricides such as bromo oxime ester or ethyl ester sterol; Growth regulators, such as fluoroantimony, chlorfenapyr, methacrylate, chlorfenapyr or diflubenzuron.

The following mixtures of the compound of the formula I with the active ingredient are preferred. Preferably, the term "TX" refers to a compound encompassed by the compound of the formula I or, preferably, the term "TX" is used. Compounds from Tables 1 to 12, A, B and C: an adjuvant selected from the group consisting of petroleum (alias) (628) + TX, an acaricide consisting of the following Selected from the group of substances: 1,1-di-(4-chlorophenyl)-2-ethoxyethanol (name of the International Union of Pure and Applied Chemistry (IUPAC)) (910) + TX, 2, 4- Chlorophenylbenzenesulfonic acid (IUPAC/Chemical abstract name) (1059) + TX, 2-fluoro-N-methyl-N-1-naphthylacetamide (IUPAC name) (1295) + TX, 4-chlorobenzene Phenyl phenyl hydrazine (IUPAC name) (981) + TX, abatin (1) + TX, hydrazine (3) + TX, acetamipridonitrile [CCN] + TX, flumethrin (9) + TX, get gram (16) + TX, oxydike (863), alpha cypermethrin (202) + TX, match (870) + TX, sulfamate [CCN] + TX, guanamine thioester ( 872) + TX, amine phosphorus (875) + TX, acid oxalate amine phosphorus (875) + TX, amitraz (24) + TX, chlorpyrifos (881) + TX, arsenic trioxide (882) + TX , AVI 382 (compound code) + TX, AZ 60541 (chemical Code) +TX, Ethyl tacrolimus (44) + TX, methyl tacrolimus (45) + TX, azobenzene (IUPAC name) (888) + TX, triazolyl (46) + TX, Azophos (889)+TX, benomyl (62)+TX, benzene Phosphorus (alias) [CCN]+TX, benzophenone (71)+TX, benzyl benzoate (IUPAC name) [CCN]+TX, Bifendrazin (74)+TX, bifenthrin (76)+ TX, lysine (907) + TX, bromomethrin (alias) + TX, bromo (918) + TX, bromo pine (920) + TX, ethyl bromide (921) + TX, Bromodecyl ester (94) + TX, chlorpyrifos (99) + TX, butanone (103) TX, butanone oxime (104) + TX, butyl daprost (alias) + TX, stone sulphur mixture (IUPAC name) (111)+TX, toxaphene (941)+TX, chlorhexazone (943)+TX, carbaryl (115)+TX, carbofuran (118)+TX, trithion ( 947) +TX, CGA 50'439 (development code) (125) + TX, cockroach (126) + TX, chlorpyrifos (959) + TX, insecticidal 964 (964) + TX, insecticidal strontium salt Acid salt (964) + TX, chlorfenapyr (130) + TX, sterol (968) + TX, decyl ester (970) + TX, diazepam (971) + TX, kefensone (131) +TX, ethyl ester sterol (975) + TX, decyl ether (977) + TX, 螟蛉 (978) + TX, propyl ester sterol (983) + TX, Taosson (145) + TX, A Chitosson (146)+TX, chloromethylphosphonium (994)+TX, fenvalerate I(696)+TX, methyrin II (696)+TX, fenvalerate (696)+TX, tetraterpenoid (158) + TX, cyanoguanidin (alias) [CCN] + TX, fly poison phosphorus (174) + TX, clomiphene (alias) [CCN] + TX, butene phosphorus (1010) + TX , thiabendazole fungicide (1013) + TX, fruit insect phosphorus (1020) + TX, butafluorodecyl ester (CAS registration number: number 400882-07-7) + TX, cyhalothrin (196) + TX, tricyclotin (199)+TX, cypermethrin (201) TX, DCPM (1032)+TX, DDT(219)+TX, Tianle phosphorus (1037)+TX, Tianle phosphorus-O(1037)+TX , Tianle Phosphorus-S(1037)+TX, Zengsongsong (1038)+TX, methyl chlorhexidine (224)+TX, chlorhexidine-O(1038)+TX, methylisomethasone ( 224)+TX, Descendants-S(1038)+TX, Descendants-S-methyl (224)+TX, sputum phosphorus (1039)+TX, dibutyl ether urea (226)+TX, derla Pine (1042) + TX, Da Lisong (227) + TX, bacteriostatic (230) + TX, diclofen (236) + TX, di-propyl phosphine (alias) + TX, dicofol (242) + TX, hundred Treatment of phosphorus (243) + TX, dechlorination (1071) + TX, mefphosphate (1081), dassam (262) + TX, bisectin (alias) (653) + TX, decylphenol ( 1089)+TX, Dyna-Dikexin (1089)+TX, enemy 螨通(269)+TX, enemy 螨普(270)+TX, enemy 螨普-4[CCN]+TX, enemy 螨普- 6[CCN]+TX, neighboring enemy annihilation (1090)+TX, penemene ester (1092)+TX Octyl nitrate acaricides (1097) + TX, butyl nitrate (1098) + TX, two Phosphorus (1102) + TX, diphenyl hydrazine (IUPAC name) (1103) + TX, disulfiram (alias) [CCN] + TX, disulfoxide (278) + TX, DNOC (282) + TX, dofenapyn ( 1113) +TX, dermametine (alias) [CCN] + TX, endosulfan (294) + TX, toxic phosphorus (1121) + TX, EPN (297) + TX, eplenomycin ( Alias) [CCN]+TX, Aizusong (309)+TX, Yishen (1134)+TX, 螨(320)+TX, Yidusong(1142)+TX, anti-carbazole (1147) +TX, quinacridone (328)+TX, phenbutyltin (330)+TX, fenthiophene (337)+TX, fenpropathrin (342)+TX, pyridoxamine (alias)+TX, azole Decyl ester (345) + TX, decyl ester (1157) + TX, aryl fluoroamine (1161) + TX, fenvalerate (349) + TX, Fenpney (354) + TX, pyrimidine (360 +TX, fluzolone (1166) + TX, fluoroaniline thiazole (1167) + TX, fluoroquinone urea (366) + TX, cyfluthrin (367) + TX, fluorinated hydrazine (1169) + TX, flubendiamide (370) + TX, flumethrin (372) + TX, fluocyanine (1174) + TX, fluvalinate (1184) + TX, FMC 1137 (development code) (1185 ) +TX, worm (405) + TX, worm + (405) + TX, Fu Musong (1192) + TX, hyperthyroidism (1193) + TX, lindane (430) + TX, fruit Green Ding (1205)+TX, Hefening (424)+TX, Feidasong (432)+TX, Ten Alkylcyclopropanecarboxylate (IUPAC/Chemical Abstract Name) (1216) + TX, thiazolone (441) + TX, methyl iodide (IUPAC name) (542) + TX, acesulfame (alias) (473 +TX, isopropanol O-(methoxyaminothiophosphonium)salicylic acid (IUPAC name) (473)+TX, ivermectin (alias) [CCN]+TX, jasperate I (696)+TX, Jasmine II (696)+TX, iodophos (1248)+TX, chlorinated benzene (430)+TX, Lufenlong (490)+TX, marathon (492)+TX , special nitrile (1254) + TX, bismuth phosphorus (502) + TX, dithia phosphorus (1261) + TX, dimethyl thiazide (alias) [CCN] + TX, insect phobia (1266) + TX, Damason (527)+TX, dexamethasone (529)+TX, chlorpyrifos (530)+TX, methomyl (531)+TX, methyl bromide (537)+TX, acetonide (550)+TX, Meiwensong (556)+TX, Ziwei (1290)+TX, Mistidine (557)+TX, Milbymycin Telluride (alias)[CCN]+TX, propylamine fluoride (1293)+TX, Speeding (561)+TX, Maoguo (1300)+TX, Mosdatin (alias)[CCN]+TX, Nai Lisong (567)+TX, NC-184 (compound code)+TX, NC- 512 (compound code) + TX, Niflulily (1309) + TX, nicotimycin (alias) [CCN] + TX, pentamidine (1313) + TX, pentamidine 1:1 zinc chloride synthesis Object (1313)+ TX, NNI-0101 (compound code) + TX, NNI-0250 (compound code) + TX Oujiesong (594) + TX, killing line (602) + TX, isobaric (1324) + TX, mixing Phosphorus (1325) + TX, pp'-DDT (219) + TX, Barlason (615) + TX, permethrin (626) + TX, petroleum oil (alias) (628) + TX, fenthion ( 1330) +TX, Sedasson (631) + TX, Fresson (636) + TX, Yubisson (637) + TX, sulfur cyclophosphine (1338) + TX, Yisong (638) + TX, Fu Misesong (639) + TX, Bassson (642) + TX, Yatesson - methyl (652) + TX, polychlorinated terpenes (known name) (1347) + TX, polynacromycin ( Alias) (653) + TX, chlorinated alcohol (1350) + TX, Bufson (662) + TX, Converse (1354) + TX, Kruth (671) + TX, chlorpyrifos (673) + TX, chlorpyrifos (678) + TX, Blessing (1360) + TX, fruit (1362) + TX, pyrethrin I (696) + TX, pyrethrin II (696) + TX, Pyrethrin (696)+TX, Qiling (699)+TX, Bifendon (701)+TX, Pidifen (706)+TX, pyrimidine phosphorus (1370)+TX, Baiyusong (711) ) +TX, Bai Yusong (1381) + TX, R-1492 (development code) (1382) + TX, RA-17 (development code) (1383) + TX, rotenone (722) + TX, octadecyl ( 1389) +TX, sulphur phosphorus (alias) + TX, serracin (alias) [CCN ]+TX, SI-0009 (compound code) + TX, Suguo (1402) + TX, spiro-ester (738) + TX, spironolactone (739) + TX, SSI-121 (development code) (1404) +TX, Shufeilun (alias) [CCN]+TX, sulfluramid (750)+TX, guanidine phosphorus (753)+TX, sulfur (754)+TX, SZI-121 (development code) (757 +TX, fluvalinate (398) + TX, pyridoxamine (763) + TX, TEPP (1417) + TX, third Dingwei (alias) + TX, insecticidal (777) + TX, Tetrachlorine (786) + TX, four antibiotics (alias) (653) + TX, killing good (1425) + TX, thiophene (alias) + TX, insect-resistant (1431) + TX, long Weiwei (800)+TX, methyl disulfoxide (801)+TX, chlorpyrifos (1436)+TX, sulindac (alias)[CCN]+TX, bismamisone (1441)+TX, Benzoquinone (1443) + TX, trilopine (820) + TX, oxazide (alias) + TX, triclosan (824) + TX, phosphorus oxychloride (1455) + TX, three live bacteria (alias) (653)+TX, sylvestre (847)+TX, fenidazole [CCN] and YI-5302 (compound code)+TX, an algicide, from a group of substances consisting of Selected: Benzene [CCN]+TX, copper dioctoate (IUPAC name) (170)+TX, copper sulfate (172)+TX, thiobenzene [CCN]+TX, dichloronaphthylquinone (1052)+TX, dihydroxydichlorodiphenylmethane (232)+TX, cadmium (295)+TX, triphenyltin (347)+TX, slaked lime [CCN ]+TX, Dyson sodium (566)+TX, Mokgrass (714)+TX, indigoamine (1379)+TX, simazine (730)+TX, triphenyltin acetate (IUPAC name) 347) and triphenyltin hydroxide (IUPAC name) (347) + TX, an anthelmintic, selected from the group consisting of: abatatin (1) + TX, breeding livestock phosphorus (1011 ) +TX, dermathistine (alias) [CCN]+TX, indomethacin (291)+TX, gamma salt (291)+TX, eplenomycin (alias)[CCN]+TX , ivermectin (alias) [CCN]+TX, milbemycin oxime (alias) [CCN]+TX, mosstatin (alias) [CCN]+TX, piperazine [CCN]+TX, serramycin (alias) [CCN]+TX, spinosyn (737) and methyl thiophanate (1435)+TX, a bird killing agent, from a group of substances consisting of Selected: chloralose (127) + TX, endrin (1122) + TX, fumicide (346) + TX, pyridin-4-amine (IUPAC name) (23) and strychnine (745) +TX, a fungicide, is selected from the group consisting of 1-hydroxy-1 hydrogen-pyridine-2-thione (IUPAC name) (1222) + TX, 4-(quinoline Oxalin-2-amino)benzenesulfonamide (IUPAC name) (748)+TX, 8-hydroxyquinoline sulfate (446)+TX, bronopol (97)+TX, copper dioctoate (IUPAC name) (170)+TX, copper hydroxide (IUPAC name) (169)+TX, cresol [CCN]+TX, diclofen (232)+TX, dithiopyridinium (1105)+TX, and doxine ( 1112) +TX, dikesone (1144) + TX, formaldehyde (404) + TX, mercury plus fen (alias) [CCN] + TX, chunleimycin (483) + TX, chunleimycin hydrochloride hydrate ( 483) +TX, nickel dimethylaminodithioate (IUPAC name) (1308) + TX, nitropyridine (580) + TX, octyl isothiophenone (590) + TX, Quinoic acid (606)+TX, oxytetracycline (611)+TX, hydroxyquinoline potassium hydrogensulfate (446)+TX, thiabendazole (658)+TX, streptomycin (744)+TX, streptavidin Sulfate (744) + TX, gram gram (766) + TX and thimerosal (alias) [CCN] + TX, a biological preparation, selected from the group consisting of: cotton brown moth ( Adoxophyes orana GV) (alias) (12) + TX, Agrobacterium radiotypes ( Agrobacterium ra two obacter ) (alias) (13) + TX, blunt species ( Amblyseius Spp.) (alias) (19) + TX, celery night moth ( Anagrapha falcifera NPV) (alias) (28) + TX, pteridophyte Anagrus atomus ) (alias) (29) + TX, 苜蓿蚜 bee ( Aphelinus abdominalis ) (alias) (33) + TX, 蚜 Coleman ( Aphidius colemani ) (alias) (34) + TX, 蚜瘿 mosquito ( Aphidoletes aphidimyza ) (alias) (35) + TX, Spodoptera frugiperda ( Autographa californica NPV) (alias) (38) + TX, Bacillus lentus ( Bacillus firmus ) (alias) (48) + TX, Bacillus sphaericus ( Bacillus sphaericus Neide) (49)+TX, Bacillus thuringiensis ( Bacillus thuringiensis Berliner) (scientific name) (51) + TX, Su Li bacteria Bacillus thuringiensis Subsp. Aizawai ) (scientific name) (51) + TX, Bacillus thuringiensis subspecies of Israel ( Bacillus thuringiensis Subsp. Israelensis ) (scientific name) (51) + TX, Bacillus thuringiensis subsp. Bacillus thuringiensis Subsp. Japonensis ) (scientific name) (51) + TX, Bacillus thuringiensis Kurstaki subspecies( Bacillus thuringiensis Subsp. Kurstaki ) (scientific name) (51) + TX, Bacillus thuringiensis Tenebrionis subspecies( Bacillus thuringiensis Subsp. Tenebrionis ) (scientific name) (51) + TX, Beauveria bassiana ( Beauveria bassiana ) (alias) (53) + TX, Beauveria bassiana ( Beauveria brongniartii ) (alias) (54) + TX, ordinary grasshopper ( Chrysoperla carnea ) (alias) (151) + TX, Meng's hidden ladybug ( Cryptolaemus montrouzieri ) (alias) (178) + TX, apple stupid moth granulosis virus ( Cydia pomonella GV) (alias) (191) + TX, Siberian bee Dacnusa sibirica ) (alias) (212) + TX, peas Diglyphus isaea ) (alias) (254) + TX, Li Wei wasp ( Encarsia formosa ) (scientific name) (293) + TX, scorpion horned bee ( Eretmocerus eremicus ) (alias) (300) + TX, American cotton bollworm ( Helicoverpa zea NPV) (alias) (431) + TX, Heterodera Heterorhabditis bacteriophora )versus H.megidis (alias) (433) + TX, poly-legged ladybug ( Hippodamia convergens ) (alias) (442) + TX, parasitic tangerine powder scale insects ( Leptomastix dactylopii ) (alias) (488) + TX, predatory artifacts ( Macrolophus caliginosus ) (alias) (491) + TX, Cabbage Mamestra brassicae NPV) (alias) (494) + TX, Metaphycus helvolus (alias) (522)+TX, Metarhizium anisopliae ( Metarhizium anisopliae Var. Acridum ) (scientific name) (523) + TX, Metarhizium ( Metarhizium anisopliae Var. Anisopliae ) (scientific name) (523) + TX, European pine rust sawdust bee ( Neodiprion sertifer NPV) and red-headed pine bee ( N.lecontei NPV) (alias) (575) + TX, small flower species ( Orius Spp.) (alias) (596) + TX, Paecilomyces fuliginea ( Paecilomyces fumosoroseus ) (alias) (613) + TX, Chilean plantation 蟍 ( Phytoseiulus persimilis ) (alias) (644) + TX, Spodoptera exigua Multicapsid nuclear polyhedrosis virus (scientific name) (741) + TX, Steinernema bibionis (alias) (742) + TX, M. elegans ( Steinernema carpocapsae ) (alias) (742) + TX, Spodoptera frugiperda ( Steinernema feltiae ) (alias) (742) + TX, Steinernema glaseri (alias) (742) + TX, Steinernema riobrave (alias) (742) + TX, Steinernema riobravis (alias) (742) + TX, M. elegans ( Steinernema scapterisci ) (alias) (742) + TX, Streptomyces elegans ( Steinernema Spp.) (alias) (742) + TX, Trichogram bee ( Trichogramma Spp.) (alias) (826) + TX, Western blind walk ( Typhlodromus occidentalis ) (alias) (844) and Verticillium lecanii ( Verticillium lecanii (alias) (848) + TX, a soil sterilant, selected from the group consisting of methyl iodide (IUPAC name) (542) and methyl bromide (537) + TX, a chemical sterilant, Selected from a group consisting of: oxazophos [CCN]+TX, bis(aziridine)methylaminophosphorus sulfide (alias) [CCN]+TX, busulfan (alias) [CCN]+TX, diflubenzuron (250)+TX, dimatif ( Alias) [CCN]+TX, hexamethylene amide [CCN]+TX, hexamethylphosphorus [CCN]+TX, methyl hydrazine [CCN]+TX, methylthiocarbamate [CCN]+TX, methyl sterility [CCN]+TX, bisphosphonazoline [CCN]+TX, fluorojumolone (alias) [CCN]+TX, 涕ba[CCN]+TX, thiohexamethylphosphorus (alias)[CCN]+TX, stopper Substitute (alias) [CCN]+TX, infertility (alias) [CCN] and urethane imine (alias) [CCN]+TX, an insect pheromones, from a group of substances consisting of Selected: (E)-dec-5-en-1-yl acetate containing (E)-dec-5-en-1-ol (IUPAC name) (222) + TX, (E) - Thirteen-4- Alken-1-carboxylic acid (IUPAC name) (829) + TX, (E)-6-methyl-2-hepten-4-ol (IUPAC name) (541) + TX, (E, Z) - fourteen Alkane-4,10-diene-1-acetate (IUPAC name) (779) + TX, (Z)-dodecene-7-ol-1-acetate (IUPAC name) (285) + TX, (Z)-hexadecyl-11-enyl aldehyde (IUPAC name) (436) + TX, (Z)-hexadecen-11-ol-1-acetate (IUPAC name) (437) + TX, ( Z)-hexadec-13-en-11-yn-1-yl acetate (IUPAC name) (438)+TX, (Z)-icos-13-en-10-one (IUPAC name) (4 48) +TX, (Z)-tetradec-7-en-1-yl (IUPAC name) (782) + TX, (Z)-tetradec-9-en-1-ol (IUPAC name) ( 783) +TX, (Z)-tetradec-9-ene-1-acetate (IUPAC name) (784) + TX, (7E, 9Z)-dodecene-7,9-olol-1 - acetate (IUPAC name) (283) + TX, (9Z, 11E) - tetradecane-9,11-diene-1-acetate (IUPAC name) (780) + TX, (9Z, 12E )-tetradecane-9,12-diene-acetate (IUPAC name) (781)+TX, 14-methyloctadec-1-ene (IUPAC name) (545)+TX, 4- Methylnonan-5-one 4-methylnonan-5-ol (IUPAC name) (544) + TX, α-polymorph (alias) [CCN] + TX, brevicomin (alias) [CCN] + TX, codlelure (alias )[CCN]+TX, dodecadienol (alias) (167)+TX, melon fly attractant (alias) (179)+TX, female gypsy moth attractant (277)+TX, twelve Alkan-8-en-1-yl acetate (IUPAC name) (286) + TX, dodecane-9-en-1-yl acetate (IUPAC name) (287) + TX, dodecane - 8+TX, 10-dien-1-yl acetate (IUPAC name) (284)+TX, Stupid attractant No. 2 (alias) [CCN]+TX, ethyl 4-octanoic acid methyl ester (IUPAC name )(317)+TX, eugenol (alias) [CCN]+TX, southern pine scorpion attractant (alias) [CCN]+TX, cotton red bell Insect attractant (alias) (420) + TX, decoy olefin mixture (421) + TX, decoy olefin mixture I (alias) (421) + TX, decoy olefin mixture II (alias) (421) + TX , decoy olefin mixture III (alias) (421) + TX, decoy olefin mixture IV (alias) (421) + TX, red bell entangled [CCN] + TX, dentate decyl alcohol (alias) [CCN ]+TX, dentate decyl alcohol (alias) [CCN]+TX, scarab attractant (alias) (481)+TX, trimethyldioxytricyclodecane (alias) [CCN]+TX, night Moth attractant (alias) [CCN]+TX, lure moth (alias) [CCN]+TX, decoy ester [CCN]+TX, tetradecadienoic acid (alias) [CCN]+TX, insecticidal ether (alias) (540)+TX, Musca domestica attractant (563)+TX, octadecene-2,13-diene-1-acetic acid (IUPAC name) (588)+TX, octadecene-3,13 -Diene-1-acetic acid (IUPAC name) (589) + TX, Ovra Road (alias) [CCN] + TX, Oritas Road (alias) (317) + TX, tetradecenyl acetate (alias) [CCN]+TX, Mediterranean fruit fly attractant [CCN]+TX, soddine (alias) (736)+TX, bacteriocin (alias) [CCN]+TX, fourteen carbon- 11-ene-1-acetate (IUPAC name) (785)+TX, Mediterranean fruit fly attractant (839)+TX, Mediterranean fruit fly attractant A (alias) (839)+TX, Mediterranean Sex attractant B1 (alias) (839) + TX, Mediterranean fruit fly attractant B2 (alias) (839) + TX, Mediterranean fruit fly attractant C (alias) (839) and Chuangke (alias) [ CCN]+TX, an insect repellent, is selected from the group consisting of: insecticidal alcohol (IUPAC name) (591) + TX, butyl trimethylated oxygen (933) + TX, butoxy (Polypropylene glycol) (936) + TX, dibutyl adipate (IUPAC name) (1046) + TX, dibutyl phthalate (1047) + TX, dibutyl succinate (IUPAC name) (1048)+TX, di-ethyl stem toluidine amine [CCN]+TX, mosquito repellent [CCN]+TX, dimethyl phthalate [CCN]+TX, ethyl diol (1137)+TX, Diethylamine, ethidium, barbital [CCN] + TX, quinoline carboxylate (1276) + TX, methyl neodecylamine [CCN] + TX, oxalate [CCN] and picarein [CCN] ]+TX, an insecticide, is selected from the group consisting of 1-dichloro-1-nitroethane (IUPAC/Chemical Abstract Name) (1058)+TX, 1,1-II Chloro-2,2-bis(4-ethylphenyl)ethane (IUPAC name) (1056)+TX, 1,2-dichloropropane (IUPAC/Chemical Abstract Name) (1062)+TX, 1,2- Dichloropropane with 1,3-dichloropropene (IUPAC name) (1063) + TX, 1-bromo-2-chloro Alkane (IUPAC / Chemical Abstract Name) (916) + TX, 2,2,2-trichloro-1-(3,4-dichlorophenyl)acetate (IUPAC name) (1451) + TX, 2, 2-Dichlorovinyl dimethyl ester 2-ethylsulfinylethyl phosphate methyl ester (IUPAC name) (1066) + TX, 2-(1,3-dithiolan-2-yl)phenyl dimethylcarbamate (IUPAC / Chemical Abstract Name) (1109) + TX, 2-(2-butoxyethoxy)ethyl thiocyanate (IUPAC / Chemical Abstract Name) (935) + TX, 2- (4, 5 -dimethyl-1,3-dioxolan-2-yl)phenyl methylcarbamate (IUPAC/Chemical Abstract Name) (1084) + TX, 2-(4-amine-3,5-xylyleneoxy)ethanol (IUPAC name) ( 986) +TX, 2-chloroethylene diethyl phosphate (IUPAC name) (984) + TX, 2-imidazolidinone (IUPAC name) (1225) + TX, 2-isopentyl-1,3- Ketone (IUPAC name) (1246) + TX, 2-methyl (prop-2-ynyl) aminophenyl methylcarbamate (IUPAC name) (1284) + TX, 2-thiocyanatoethyl laurate (IUPAC name) (1433) + TX, 3-bromo 1-chloro-1-propene (IUPAC name) (917) + TX, 3-methyl-1-phenylpyrazol-5-yl dimethyl carbamate (IUPAC name) (1283) + TX, 4-methyl (prop-2- Alkyne) Amine-3,5-dimethylphenylaminocarbamate (IUPAC name) (1285)+TX, 5,5-dimethyl-3- Oxocyclohex-1-enyl dimethylcarbamate (IUPAC name) (1085) + TX, abatatin (1) + TX, chlorfenapyr (2) + TX, acetamiprid (4) + TX, housefly phosphorus (alias) [ CCN]+TX, acetaminophen [CCN]+TX, flumethrin (9)+TX, acrylonitrile (IUPAC name) (861)+TX, cotton ring (15)+TX, get gram (16 ) +TX, Oxygen (863) + TX, Aldrin (864) + TX, allylmethrin (17) + TX, alemsin (alias) [CCN] + TX, disinfection (866) + TX, á-cypermethrin (202) + TX, á-ecdysone (alias) [CCN] + TX, aluminum phosphide (640) + TX, match (870) + TX, guanamine thioester ( 872)+TX, chlorpyrifos (873)+TX, amine phosphorus (875)+TX, acid oxalate amine (875)+TX, amitraz (24)+TX, neonicotinoid (877) +TX, ethyl chlorpyrifos (883) + TX, AVI 382 (compound code) + TX, AZ60541 (compound code) + TX, azadirachtin (alias) (41) + TX, sub-desin (42) + TX , Ethyl tamarind (44) + TX, methyl tacrolimus (48) + TX, azo (889) + TX, Bacillus thuringiensis δ - endotoxin (alias) (52) +TX, bismuth fluoroantimonate (alias) [CCN]+TX, bismuth polysulfide (IUPAC/chemical abstract name) (892)+TX, pepper pyrethrum [CCN]+TX, Bayer 22/190 (development code) (893) + TX, Bayer 22408 (development code) (894) + TX, Insect (58)+TX, propylthiocarbamate (60)+TX, insecticidal sulfonate (66)+TX, â-cyfluthrin (194)+TX, beta-cypermethrin (203)+TX, bifenthrin (76) + TX, bio-methrin (78) + TX, propyl methrin S-cyclopentenyl isomer (alias) (79) + TX, bioethanomethrin [CCN] + TX, biological chlorine Pyrethroid (908) + TX, bio-insecticide (80) + TX, bis (2-chloroethyl) ether (IUPAC name) (909) + TX, bistrifluoroidazolium (83) + TX, borax ( 86) +TX, bromostat (alias) + TX, methyl bromide (914) + TX, bromo (918) + TX, bromine DDT (alias) [CCN] + TX, bromo pine (920)+TX, ethyl bromide (921)+TX, butylanilide (924)+TX, chlorpyrifos (99)+TX, butyl methacrylate (926)+TX, demethylated Pyrimidine phosphine (927)+TX, butanone (103)+TX, butyl phosphate (932)+TX, butanone oxime (104)+TX, butyldaprofen (alias)+TX, sulphur phosphorus (109) + TX, calcium arsenate [CCN] + TX, calcium cyanide (444) + TX, stone sulfur mixture (IUPAC name) (111) + TX, toxaphene (941) + TX, chlorpyrifos ( 943) +TX, carbaryl (115) + TX, carbofuran (118) + TX, carbon disulfide (IUPAC / chemical abstract name) (945) + TX, carbon tetrachloride (IUPAC name) (946) + TX ,three Phosphorus (947) + TX, butyl thiocarbazone (119) + TX, chlorpyrifos (123) + TX, chlorpyrifos hydrochloride (123) + TX, sivadine (alias) (725) + TX, Borneol Dan (960)+TX, Chlordane (128)+TX, Chlordecone (963)+TX, Insecticidal (964)+TX, Insecticidal Hydrochloride (964)+TX, Oxychloride Phosphorus (129)+TX, chlorfenapyr (130)+TX, kefensone (131)+TX, chlorfenapyr (132)+TX, chloromethylphosphonium (136)+TX, chloroform [CCN]+TX , Trichloronitromethane (141) + TX, chloronitrile phosphine (989) + TX, insecticidal pyridine (990) + TX, Dossson (145) + TX, methyl tausson (146) + TX, chloromethyl sulfide Phosphorus (994)+TX, Cyclosporin (150)+TX, fenvalerate I(696)+TX, methyrin II (696)+TX, fenvalerate (696)+TX, cis-resmethrin (alias) +TX, cismethrin (80) + TX, cyhalothrin (alias) + TX, in addition to line (999) + TX, cyanoguanidine (alias) [CCN] + TX, clothianidin (165 ) +TX, acetonitrile copper arsenate [CCN] + TX, copper arsenate [CCN] + TX, copper oleic acid [CCN] + TX, fly poison phosphorus (174) + TX, livestock phosphorus (1006) + TX, Cromiton (alias) [CCN]+TX, butene phosphorus (1010)+TX, breeding livestock phosphorus (1011)+TX, cryolite (alias) (177)+TX, CS 708 (development code) (1012)+TX, benzonitrile phosphorus (1019)+TX, acaricidal nitrile (18 4) +TX, fruit worm phosphorus (1020) + TX, ringworm chrysanthemum [CCN] + TX, fenpropathrin (188) + TX, cyfluthrin (193) + TX, cyhalothrin (196) + TX, cypermethrin (201) + TX, cyprofen (206) + TX, chlorfenapyr (209) + TX, chlorpyrifos (alias) [CCN] + TX, celery (alias) [CCN] +TX, dextromethrin (alias) (788) + TX, DAEP (1031) + TX, cotton (216) + TX, DDT (219) + TX, plus Bao Fu (1034) + TX, bromide Pyrethroid (223)+TX, Tianle Phosphorus (1037)+TX, Tianle Phosphorus-O(1037)+TX, Tianle Phosphorus-S(1037)+TX, Cecidate (1038)+TX, Methyl Dexamesone (224)+TX, Descendants-O(1038)+TX, methylisomethasone (224)+TX, chlorhexidine-S-methyl (1038)+TX, cecissin- S-methyl (224)+TX, sputum phosphorus (1039)+TX, dibutyl ether urea (226)+TX, derasson (1042)+TX, diamine phosphorus (1044)+TX, dansson (227 ) +TX, isothiophos (1050) + TX, dephosphorization (1051) + TX, diclofen (236) + TX, dipropyl phosphine (alias) + TX, dicresyl (alias) [CCN] + TX , Baizhi phosphorus (243) + TX, cyclosporin (244) + TX, dieldrin (1070) + TX, diethyl 5-methyl-3-pyrazole phosphate (IUPAC name) (1076) + TX, diflubenzuron (250) + TX, dihydroxypropyl theophylline (alias) [CCN] + TX, tetrafluoro Ethyl cholate [CCN] + TX, mefphosphate (1081) + TX, dime (1085) + TX, dass (262) + TX, fenthrin (1083) + TX, methyl kefensone (265)+TX, Diptera (1086)+TX, decylphenol (1089)+TX, Daina-Dikexin (1089)+TX, nitrophenol (1093)+TX, pentophenol (1094) ) +TX, dinol (1095) + TX, dinotefuran (271) + TX, benzophenone (1099) + TX, fruit and vegetable phosphorus (1100) + TX, dioxin (1101) + TX, two Phosphorus (1102)+TX, disulfiramone (278)+TX, desithrolide (1108)+TX, DNOC(282)+TX, dermametin (alias)[CCN]+TX, DSP(1115 ) +TX, ecdysterone (alias) [CCN] + TX, EI 1642 (development code) (1118) + TX, gamma salt (291) + TX, statin benzoate (291) + TX, EMPC(1120)+TX, dextromethrin (292)+ TX, endosulfan (294)+TX, toxic phosphorus (1121)+TX, endrin (1122)+TX, EPBP (1123) +TX, EPN(297)+TX, juvenile ether (1124)+TX, Epleno (alias) [CCN]+TX, S-fenvalerate (302)+TX, italabine (alias) [CCN]+TX, insecticidal (308)+TX, Aibo (309)+TX, ethiprole (310)+TX, dithizone (1134)+TX, Pfsson (312)+TX Ethyl formate (IUPAC name) [CCN]+TX, ethyl-DDD (alias) (1056)+TX, dibromoethylene (316)+TX, dichloroethane (chemical name) (1136)+TX, ring Oxyethane [CCN]+TX, etofenproxate (319)+TX, prednisone (1142)+TX, EXD(1143)+TX, sulfaphos (323)+TX, fentansone (326)+ TX, anti-carbazole (1147) + TX, picophos (1148) + TX, diethyl phenol methyl urethane (1149) + TX, fenfluramine (1150) + TX, chlorfen (335)+TX, Zhongdingwei (336)+TX, Fenofali (1153) +TX, phenoxycarb (340) + TX, beta-cypermethrin (1155) + TX, fenpropathrin (342) + TX, pyridoxamine (alias) + TX, Fanfusong (1158) + TX, fumicide (346)+TX, ethylfensonate [CCN]+TX, fenvalerate (349)+TX, fentanyl (354)+TX, fluramide (358)+TX, flubendivir Amine (CAS. Registration No.: 272451-65-7) + TX, flucofuron (1168) + TX, fluoroquinone urea (366) + TX, cyfluthrin (367) + TX, fluorinated hydrazine (1169) + TX , pyrimethanil [CCN] + TX, flubendiamide (370) + TX, trimethrin (1171) + TX, flumethrin (372) + TX, fluvalinate (1184) + TX, FMC 1137 (development code) (1185) + TX, Dafusong (1191) + TX, worm (405) + TX, worms (405) + TX, Fu Musong (1192) + TX, formazan (1193) + TX, butyl thiophene (1194) + TX, formazin (1195) + TX, forsythia (408) + TX, selebrane (1196) + TX, furosemide ( 412) +TX, furfural (1200) + TX, super efficient cyhalothrin (197) + TX, lindane (430) + TX, biguanide salt (422) + TX, biguanide acetate (422) + TX, GY-81 (development code) (423) + TX, fenfenine (424) + TX, chlorantranil (425) + TX, HCH (430) + TX, HEOD (1070) + TX, heptachlor (1211 ) +TX, Feidasong (432) +TX, chlorpyrifos [CCN]+TX, hexaflumuron (439)+TX, HHDN(864)+TX, fluoroantimony (443)+TX, hydrogen cyanide (444)+TX, enebene B Ester (445) + TX, hyquincarb (1223) + TX, idadine (458) + TX, methadin (460) + TX, indoxacarb (465) + TX, methyl iodide (IUPAC name) (542 ) +TX, IPSP (1229) + TX, chlorpyrifos (1231) + TX, carbochlorin (1232) + TX, acesulfame (alias) (473) + TX, isoprene (1235) + TX, Isophosphorus (1236)+TX, Ilan (1237)+TX, chlorhexidine (472)+TX, isopropanol O-(methoxyaminothiophosphonium)salicylate (IUPAC) Name) (473)+TX, Indigo (474)+TX, Heterophosphorus (1244)+TX, Jiafusong (480)+TX, Ivermectin (alias) [CCN]+TX, Jasmine I(696)+TX, jasperate II (696)+TX, iodophos (1248)+TX, juvenile hormone I (alias)[CCN]+TX, juvenile hormone II (alias)[CCN]+ TX, juvenile hormone III (alias) [CCN]+TX, Klevan (1249)+TX, protosan (484)+TX, lambda-cyhalothrin (198)+TX, lead arsenate [CCN]+TX, lepimectin(CCN)+TX, p-bromophosphorus (1250)+TX, chlorinated benzene (430)+TX, lirimfos(1251)+TX, Lufenlong(490)+TX, Fusai Absolutely (1253)+TX, m Methyl cumylaminocarbamate (IUPAC name) (1014) + TX, magnesium phosphide (IUPAC name) (640) + TX, marathon (492) + TX, terpene nitrile (1254) + TX, azide Phosphorus (1255)+TX, chlorpyrifos (502)+TX, methyl acaricidal (1258)+TX, chlorpyrifos (1260)+TX, dithiaphos (1261)+TX, mercuric chloride ( 513) +TX, mesulfenfos (1263) + TX, cyanofluorfen (CCN) + TX, Weibaimu (519) + TX, metam-potassium (alias) (519) + TX, Wei is mu (519) + TX, worms (1266) + TX, damasson (527) + TX, methotrexate fluoride (IUPAC / chemical abstract name) (1268) + TX, dexamethasone (529) + TX, insecticide (530 +TX, insecticidal ethylene phosphorus (1273) + TX, chlordane (531) + TX, methoprene (532) + TX, quinoline carboxylate (1276) + TX, pyrethrin (alias) ( 533) +TX, methoxychlor (534) + TX, methoxy worm (535) + TX, methyl bromide (537) + TX, methyl isothiocyanate (543) + TX, trichloroethane (alias )[CCN]+TX, dichloromethane [CCN]+TX, trimethoprim [CCN]+TX, quick kill (550)+TX, Insectone (1288)+TX, Meiwensong (556)+TX, self-kewei (1290)+TX, chlorhexidine (557)+TX, milbemycin oxime (alias)[CCN]+TX, propylamine fluoride (1293)+TX, anthill (1294)+TX, yawrin (561)+TX, Maoguo (1300)+TX, mosstatin (alias)[CCN]+TX, naphthoquinone phosphorus (alias )[CCN]+TX, Nai Lisong (567)+TX, naphthalene (IUPAC/Chemical Abstract Name) (1303)+TX, NC-170 (development code) (1306)+TX, NC-184 (compound code) +TX, nicotine (578) + TX, nicotine sulfate (578) + TX, nifluli (1309) + TX, nitenpyram (579) + TX, thiazide (1311)+TX, pentanyl (1313)+TX, pentanyl 1:1 zinc chloride complex (1313)+TX, NNI-0101 (compound code)+TX, NNI-0250 (compound code)+ TX, nornicotine (known name) (1319) + TX, diphenylfluorourea (585) + TX, polyfluoro urea (586) + TX, O -5-dichloro-4-indophenol- O -ethyl phosphorothioate (IUPAC name) (1057) + TX, O, O -diethyl O -4-methyl-2-oxo-2 H -chromen-7-yl phosphorothioate (IUPAC name) (1074) + TX, O, O -diethyl O -6-methyl-2-propylpyrimidin-4-yl phosphorothioate (IUPAC name) (1075) + TX, O, O, O ', O '-Tetrapropyl dithio pyrophosphate (IUPAC name) (1424) + TX, oleic acid (IUPAC name) (593) + TX, eugenium (594) + TX, kill line (602) + TX , edrosone (609)+TX, acetonide (1324)+TX, phloem (1325)+TX, pp'-DDT(219)+TX, p-dichlorobenzene [CCN]+TX, balason (615) + TX, methyl-balazon (616) + TX, fluoro-urea (alias) [CCN] + TX, pentachlorophenol (623) + TX, pentachlorophenyl laurate (IUPAC name) ( 623) +TX, permethrin (626) + TX, petroleum oil (alias) (628) + TX, PH 60-38 (development code) (1328) + TX, fenthion (1330) + TX, phenyl ether Pyrethroid (630)+TX, Sedasson (631)+TX, Fresson (636)+TX, Yubisson (637)+TX, sulfur cyclophosphine (1338)+TX, Yisongsong (638)+ TX, p-chlorosulfate (1339) + TX, bismamisone (639) + TX, phosphine (IUPAC name) (640) + TX, Paceson (642) + TX, methyl bassason (1340 ) +TX, pirimetaphos (1344) + TX, anti-River (651) + TX, ethyl pyrimidine (1345) + TX, atesson-methyl (652) + TX, polychlorodicyclopentadiene isomers (IUPAC name) (1346 +TX, polychlorinated terpenes (known name) (1347) + TX, potassium arsenite [CCN] + TX, potassium thiocyanate [CCN] + TX, acetyl methionine (655) + TX, Mature I (alias) [CCN]+TX, presenilin II (alias) [CCN]+TX, presenilin III (alias) [CCN]+TX, primidophos (1349)+TX, Bufeisong (662)+TX , fenfluthrin [CCN] + TX, Converse (1354) + TX, chlorpyrifos (1355) + TX, chlorpyrifos (1356) + TX, methionem (673) + TX, propoxur ( 678) +TX, Bifford (1360) + TX, propionate (686) + TX, hair (1362) + TX, protrifenbute [CCN] + TX, pymetrozine (688) + TX, Bai Kesong ( 689)+TX, fixed bacteria phosphorus (693)+TX, pyresmethrin (1367)+TX, pyrethrin I (696)+TX, pyrethrin II (696)+TX, pyrethrin (696) +TX, 哒螨灵(699)+TX, dichloropropene (700)+TX, bifensone (701)+TX, piroxicam (706)+TX, pyrimidine phosphorus (1370)+TX, pyriproxyfen (708)+TX, Bitterwood (alias)[CCN]+TX, Baiyusong (711)+TX, Baiyusong-Methyl (1376)+TX, quinothion(1380)+TX, Baiyusong (1381) + TX, R-1492 (development code) (1382) + TX, Rafanet (alias) [CCN] + TX, fenfenyl (719) + TX, rotenone (722) + TX, RU 15525 (development code) (723) + TX, RU 25475 (development code) (1386) + TX, fish nitin (alias) (1387) + TX, L'Alan (known name) (1387) + TX, Sabah gourd (alias) (725)+TX, octaphosphorus (1389)+TX, sulphur phosphorus (alias)+TX, serramycin (alias)[CCN]+TX, SI-0009 (compound code)+TX, SI-0205 ( Compound code) + TX, SI-0404 (compound code) + TX, SI-0405 (compound code) + TX, flumethrin (728) + TX, SN 72129 (development code) (1397) + TX, arsenic Sodium [CCN] + TX, sodium cyanide (444) + TX, sodium fluoride (IUPAC / chemical abstract name) (1399) + TX, sodium hexafluoroantimonate (1400) + TX, sodium pentachlorophenol ( 623) + TX, sodium selenate (IUPAC name) (1401) + TX, sodium thiocyanate [CCN] + TX, Suguo (1402) + TX, spinosyn (737) + TX, mollusc methyl ester (739)+TX, molluscicidal ethyl ester (CCN)+TX, sulcofuron(746)+TX, sulcofuron-sodium(746)+TX, flubendiamide (750)+TX, guanidine phosphorus (753)+TX , sulphur fluoride (756) + TX, thiopropyl phosphorus (1408) + TX, tar (alias) (758) + TX, fluvalinate (398) + TX, thiazide (1412) + TX, TDE (1414) + TX, Defeno (762) + TX, pyridoxamine (763) + TX, Tebson (764) + TX, Fumaron (768) + TX, tefluthrin (769) + TX, Apexon (770) + TX, TEPP (1417) + TX, cyclopentimeryl (1418) + TX, third butyl (alias) + TX, tofosson (773) + TX, tetrachloro Ethane [CC N]+TX, insecticidal (777)+TX, methrin (787)+TX, high-efficiency transcypermethrin (204)+TX, thiacloprid (791)+TX, thiophene (alias)+TX Bug (792)+TX, thicrofos (1428)+TX, insect-resistant (1431)+TX, insecticidal ring (798)+TX, thiophanate (798)+TX, thiodicarb (799)+TX, long Weiwei (800)+TX, methyl disulfoxide (801)+TX, sulfur (1434) + TX, thiosultap (803) + TX, thiosultap-sodium (803) + TX, sulindac (alias) [CCN] + TX, oxazolamide (809) + TX, tetramethrin ( 812) +TX, tetrafluthrin (813) + TX, transpermethrin (1440) + TX, fetamethasone (1441) + TX, oxazolidine (818) + TX, triple-loose (820) + TX, Oxime (alias) + TX, triclosan (824) + TX, trichlormetaphos-3 (alias) [CCN] + TX, soil phosphorus (1452) + TX, phosphorus oxychloride (1455) + TX, Killing chlorinated urea (835) + TX, chlorpyrifos (840) + TX, enedisulfonyl ester (1459) + TX, sylvestris (847) + TX, fenidazole [CCN] + TX, cucurbitine (alias (725)+TX, cucurbitine (alias) (725)+TX, XMC(853)+TX, chlorpyrifos (854)+TX, YI-5302 (compound code)+TX, Z-cypermethrin 205) +TX, zetamethrin (alias) + TX, zinc phosphide (640) + TX, zolaprofos (1469) and ZXI 8901 (development code) (858) + TX, cyanamide [736994-63-19] + TX, chlorantamine [500008-45-7] + TX, cyenopyrafen [560121-52-0] + TX, butylated fluoro ester [400882-07-7] + TX, pyrifluquinazon [337458-27-2] + TX, Cinot [187166-40-1+187166-15-0]+TX, molluscicidal ethyl ester [203313-25-1]+TX, fluramide nitrile [946578-00-3]+TX , butenphene [704886-18-0] + TX, fenfluthrin [915288-13-0] + TX, tetrafluthrin [84937-88-2] + TX, a mollusc The agent is selected from the group consisting of: Ding Woxi (IUPAC name) (913) + TX, bromoacetamide [CCN] + TX, calcium arsenate [CCN] + TX, in addition to line ( 999)+TX, acetonitrile copper arsenate [CCN]+TX, copper sulfate (172)+TX, triphenyltin (347)+TX, iron phosphate (IUPAC name) (352)+TX, tetraacetaldehyde (518) + TX, chlorfenapyr (530) + TX, niclosamide (576) + TX, Nike mollusk ethanolamine salt (576) + TX, pentachlorophenol (623) + TX, sodium pentachlorophenol ( 623) +TX, thiazide (1412) + TX, thiodicarb (799) + TX, tributyltin oxide (913) + TX, snail mollusc net (1454) + TX, mixed killing (840) +TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347) + TX, pyriprol [394730-71-3] + TX, a nematicide, is from Selected from the following group of substances: AKD-3088 (compound code) + TX, 1,2-dibromo-3-chloropropane (IUPAC / chemical abstract name) (1045) + TX, 1,2-dichloro Propane (IUPAC / Chemical Abstract Name) (1062) + TX, 1,2-dichloropropane contains 1,3-two Propylene (IUPAC name) (1063) + TX, 1,3-dichloropropene (233) + TX, 3,4-dichlorotetrahydrothiophene 1, 1-dioxide (IUPAC / chemical abstract name) (1065) + TX, 3- ( 4-chlorophenyl)-5-methylrhodanin (IUPAC name) (980)+TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid (IUPAC name) (1286)+ TX, 6-isopentenylaminopurine (alias) (210)+TX, abatatin (1)+TX, acetaminophen [CCN]+TX, cotton bollworm (15)+TX, derkeke ( 16) +TX, Oxygen (863) + TX, AZ 60541 (compound code) + TX, benclothiaz [CCN] + TX, benomyl (62) + TX, butyl daprofen (alias) + TX , sulphur phosphorus (109) + TX, carbofuran (118) + TX, carbon disulfide (945) + TX, butyl thiocarbazone (119) + TX, trichloronitromethane (141) + TX, Taosson ( 145) +TX, in addition to line (999) + TX, cytokinin (alias) (210) + TX, cotton (216) + TX, DBCP (1045) + TX, DCIP (218) + TX, diamine Phosphorus (1044)+TX, dephosphorization (1051)+TX, dipropylphosphine (alias)+TX, Dasongsong (262)+TX, dermametin (alias)[CCN]+TX, Avi Salt (291)+TX, Incomgent benzoate (291)+TX, Eplenomycin (alias) [CCN]+TX, Pfsson (312)+TX, Dibromoethylene (316) +TX, fentansone (326) + TX, pyridoxamine (alias) + TX, Fanfusong (1158) + TX, Fusai (408) + TX, scutellaria (1196) + TX, furfural (alias )[CCN]+TX, GY-81(development code)(423)+TX, chlorpyrifos [CCN]+TX, iodomethane (IUPAC name) (542)+TX, isamidofos(1230)+TX, Killing pine (1231) + TX, ivermectin (alias) [CCN] + TX, furan methyl adenine (alias) (210) + TX, methyl quinone phosphorus (1258) + TX, Weibaimu ( 519) +TX, metam-potassium (alias) (519) + TX, Wei is mu (519) + TX, methyl bromide (537) + TX, methyl isothiocyanate (543) + TX, mirabimycin Compound (alias) [CCN]+TX, Mustardin (alias) [CCN]+TX, Myrothecium verrucaria composition (alias) (565)+TX, NC-184 ( Compound code) +TX, kill line (602) + TX, Fresson (636) + TX, Fetish miso (639) + TX, Fusika [CCN] + TX, sulfur phosphorus (alias) + TX, Serramycin (alias) [CCN]+TX, spinosyn (737)+TX, third butyl (alias)+TX, tofusone (773)+TX, tetrachlorothiophene (IUPAC/chemical abstract name) 1422) +TX, thiophene (alias) + TX, thiophosphorus (1434)+TX, three-loose (820)+TX, oxazide (alias)+TX, xylenol [CCN]+TX, YI-5302 (compound code) and zeatin (alias) (210)+ TX, flensulfone [318290-98-1]+TX, nitrification inhibitor, is selected from the group consisting of potassium ethyl xanthate [CCN] and nitropyridine (580) + TX, a plant The activator is selected from the group consisting of: axibella (6) + TX, arsenic benzene-S-methyl (6) + TX, thiabendazole (658) and knotweed ( Reynoutria sachalinensis Extract (alias) (720) + TX, a rodenticide, is selected from the group consisting of 2-isoamyl-1,3-indanedione (IUPAC name) (1246) +TX, 4-(quin Oxalin-2-amino) benzenesulfonamide (IUPAC name) (748) + TX, alpha-chlorohydrin [CCN] + TX, aluminum phosphide (640) + TX, ant (880) + TX, arsenic trioxide (882) +TX, cesium carbonate (891) + TX, double mouse urea (912) + TX, Dalong (89) + TX, bromadiolone (91) + TX, bromine murine (92) + TX, calcium cyanide ( 444) +TX, chloralose (127) + TX, chlorflumente (140) + TX, vitamin D3 (alias) (850) + TX, chlortetracycline (1004) + TX, gram-killing mouse (1005) +TX, rodent killer (175) + TX, rat death (1009) + TX, mouse gram (246) + TX, timolone (249) + TX, enemy mouse (273) + TX, calcified alcohol ( 301) +TX, flurazepam (357) + TX, fluridamide (379) + TX, flurazepam (1183) + TX, flupropadine hydrochloride (1183) + TX, lindane (430) + TX, HCH ( 430) +TX, hydrogen cyanide (444) + TX, methyl iodide (IUPAC name) (542) + TX, chlorinated benzene (430) + TX, magnesium phosphide (IUPAC name) (640) + TX, methyl bromide (537)+TX, murine Trane (1318)+TX, tetramine (1336)+TX, phosphine (IUPAC name) (640)+TX, phosphorus [CCN]+TX, murmurone (1341) +TX, potassium arsenite [CCN]+TX, rodent control (1371)+TX, red squid (1390)+TX, sodium arsenite [CCN]+TX, sodium cyanide (444)+TX, Sodium fluoroacetate (735) + TX, horse Subbase (745) + TX, barium sulfate [CCN] + TX, warfarin (851) and zinc phosphide (640) + TX, a synergist, is selected from the group consisting of: 2 -(2-butoxyethoxy)ethyl piperonylate (IUPAC name) (934)+TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (IUPAC name) (903)+TX, gold Acacia and Neroli third alcohol (alias) (324) + TX, MB-599 (development code) (498) + TX, MGK 264 (development code) (296) + TX, sunflower butanol (649) + TX, synergistic aldehyde (1343) + TX, propyl isomer (1358) + TX, S421 (development code) (724) + TX, synergistic chrysanthemum (1393) + TX, sesame oil (1394) and Aachen (1406) + TX, a veterinary repellent, is selected from the group consisting of 蒽醌(32)+TX, chloralose (127)+TX, copper naphthenate [CCN]+ TX, copper oxychloride (171) + TX, dansson (227) + TX, dicyclopentadiene (chemical name) (1069) + TX, biguanide salt (422) + TX, biguanide acetate (422) + TX, chlorfenapyr (530) + TX, pyridin-4-amine (IUPAC name) (23) + TX, thiram (804) + TX, chlorpyrifos (840) + TX, zinc naphthenate [CCN] And dimethylamine zincate (856) + TX, a viricide, is from Manan (alias) [CCN] and A wound protectant selected from the group consisting of oxazolyl (alias) [CCN]+TX is selected from the group consisting of oxidized mercury (512) + TX and octyl isothiophenone (590). And thiophanate-methyl (802) + TX, and biologically active compounds, are selected from the group consisting of: Nitroconazole (60207-31-0) + TX, dibenzotriazole alcohol [70585] -36-3]+TX, carbendazole [116255-48-2]+TX, cyproconazole [94361-06-5]+TX, Etherazole [119446-68-3]+TX, diniconazole [83657-24-3]+TX, epoxiconazole [106325-08-0]+TX, nitrile azole [114369-43-6]+TX Fluoroquinazole [136426-54-5]+TX, flucarbazole [85509-19-9]+TX, fluconazole [76674-21-0]+TX, hexaconazole [79983-71-4] +TX, imazalil [35554-44-0]+TX, imidazole [86598-92-7]+TX, inocastazole [125225-28-7]+TX, mexazole [125116-23-6 ]+TX, myclobutanil [88671-89-0]+TX, rice glutamate [101903-30-4]+TX, penconazole [66246-88-6]+TX, prothioconazole [178928- 70-6]+TX, pyridine plaque [88283-41-4]+TX, prochloraz [67747-09-5]+TX, propiconazole [60207-90-1]+TX, guanidazole [ 149508-90-7]+TX, tebuconazole [107534-96-3]+TX, tetrafluoroetherazole [112281-77-3]+TX, triazolone [43121-43-3]+TX, three Oxazol [55219-65-3]+TX, fluconazole [99387-89-0]+TX, sterilized azole [131983-72-7]+TX, cyprodinol [12771-68-5]+TX , chloropyrimidinol [60168-88-9]+TX, fluoropyrimidinol [63284-71-9]+TX, acetaminophen sulfonate [41483-43-6]+TX, dipyridamole [ 5221-53-4]+TX, acetaminophen [23947-60-6]+TX, carbendazim [1593-77-7]+TX, fenpropidin [67306-00-7]+TX, butylbenzene Morpholine [67564-91-4]+TX, soft body Cyclosporin [118134-30-8]+TX, tridemorpholine [81412-43-3]+TX, cyprodinil [121552-61-2]+TX, azoxystrobin [110235-47- 7]+TX, pyrimethanil [53112-28-0]+TX, seed dressing [74738-17-3]+TX, fluke nitrile [131341-86-1]+TX, benzophene [71626- 11-4]+TX, furosemide [57646-30-7]+TX, metalaxyl [57837-19-1]+TX, R metalaxyl [70630-17-0]+TX, furosemide [58810-48-3]+TX, 霜灵[77732-09-3]+TX, benomyl [17804-35-2]+TX, carbendazim [10605-21-7]+TX, imiprozil [62732-91-6]+TX , Mai Suining [3878-19-1]+TX, thiabendazole [148-79-8]+TX, ethyl bacillus [84332-86-5]+TX, sclerotia [24201-58-9] +TX, iprodione [36734-19-7]+TX, myclozoline[54864-61-8]+TX, procymidone [32809-16-8]+TX, vinyl nucleus [50471-44-8 ] +TX, pyridine amide [188425-85-6] + TX, rust rust [5234-68-4] + TX, mezylamine [24691-80-3] + TX, Fudonin [66332] -96-5]+TX, rust-eliminating amine [55814-41-0]+TX, oxidized rust rust [5259-88-1]+TX, pirfenidazole [183675-82-3]+TX, thiophene Furosemide [130000-40-7]+TX, biguanide salt [108173-90-6]+TX, Duoguoding [2439-10-3][112-65-2](free base)+TX, biguanide Octamine [13516-27-3] + TX, azoxystrobin [131860-33-8] + TX, ether myramine [149961-52-4] + TX, enestrobin {Proc. BCPC, Int. Congr .,Glasgow,2003,1,93}+TX, fluoxastrobin [361377-29-9]+TX, oxystrobin [143390-89-0]+TX, phenoxystrobin [133408-50-1 ] +TX, trifloxystrobin [141517-21-7] + TX, orysastrobin [248593-16-0] + TX, picoxystrobin [117428-22-5] + TX, pyraclostrobin [175013- 18-0]+TX, Fami Iron [14484-64-1]+TX, Mancozeb [8018-01-7]+TX, Mansen Manganese [12427-38-2]+TX, Daisenlian [9006-42-2]+TX , Bensen zinc [12071-83-9] + TX, Fumei double [137-26-8] + TX, Daisen zinc [12122-67-7] + TX, dimethyl amine zinc hydride [137-30- 4]+TX, dichlorpyrifos [2425-06-1]+TX, captan[133-06-2]+TX, bacteriostatic [1085-98-9]+TX, chlorochlorin nuclear [ 41205-21-4]+TX, sterilized Dan [133-07-3]+TX, toluene sulfonamide [731-27-1]+TX, Bordeaux mixture [8011-63-0]+TX, copper hydroxide [ 20427-59-2]+TX, copperoxychlorid[1332-40-7]+TX, coppersulfat[7758-98-7]+TX, copperoxid[1317-39-1]+TX, mancozeb [53988-93] -5]+TX, quinoline copper [10380-28-6]+TX, enemies [131-72-6]+TX, trifloxystrobin [10552-74-6]+TX, enemies phosphorus [17109] -49-8]+TX, 瘟 瘟 [ [26087-47-8]+TX, 瘟 瘟 [50512-35-1]+TX, chlorpyrifos [36519-00-3]+TX, bacterium Phosphorus [13457-18-6]+TX, methyl chlorpyrifos [57018-04-9]+TX, arsenic acid benzene-S-methyl [135158-54-2]+TX, carbendazim [101] -05-3]+TX, benthiavalicarb[413615-35-7]+TX, ash sputum [2079-00-7]+TX, sputum sputum [2439-01-2]+TX, chloroanisole [ 2675-77-6]+TX, bacteria [1897-45-6]+TX, cycloflufenamide [180409-60-3]+TX, cymoxanil [57966-95-7]+TX, dichloronaphthylquinone [117-80-6]+TX ,dicocymet[139920-32-4]+TX, chlorfenone [62865-36-5]+TX, chloramine [99-30-9]+TX, carbendazim [87130-20-9]+TX , olefin morpholine [110488-70-5] + TX, SYP LI90 (fluoromorpholine) [211867-47-9] + TX, dicyanoquinone [3347-22-6] + TX, thiazolam [ 162650-77-3]+TX, soil fungus [2593-15-9]+TX, Izamidone [131807-57-3]+TX, fenamidone [161326-34-7]+TX, cyanamide [115852-48-7]+TX, triphenyltin [668-34-8]+ TX, Azoxystrobin [89269-64-7]+TX, fluazinam [79622-59-6]+TX, fluroxypyramine [239110-15-7]+TX, sulfamethamine [106917-52-6 ]+TX, fenhexamid[126833-17-8]+TX, aluminum triethylphosphonate [39148-24-8]+TX, Mold [10004-44-1]+TX, 缬Mulberry [140923-17-7]+TX, IKF 916 (cyanosin) [120116-88-3]+TX, chunleimycin [6980-18- 3]+TX, sulfonamide [66952-49-6]+TX, metrafenone[220899-03-6]+TX, pentosan[66063-05-6]+TX, tetrachlorobenzoquinone [27355-22 -2]+TX, polyoxin [11113-80-7]+TX, thiabendazole [27605-76-1]+TX, downy mildew [25606-41-1]+TX, proquinazid[189278- 12-4]+TX, praziquantel [57369-32-1]+TX, quinoxaline [124495-18-7]+TX, pentachloronitrobenzene [82-68-8]+TX, sulfur [ 7704-34-9]+TX, tiadinil[223580-51-6]+TX, imidazole [72459-58-6]+TX, tricyclazole [41814-78-2]+TX, Amine [26644-46-2]+TX, Jinggangmycin[37248-47-8]+TX, guanosamine (RH7281)[156052-68-5]+TX, diacetylergicillin [374726-62 -2]+TX, isopyrazam[881685-58-1]+TX, sedaxane[874967-67-6]+TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid(9-dichloromethylene-1 , 2,3,4-tetrahydro-1,4-methano-napht halen-5-yl)-amide (disclosed in WO 2007/048556) + TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic Acid[2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethyl]-amide (disclosed in WO 2008/148570) + TX, 1-[4-[4-[(5S)5-( 2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol- 3-yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3- (trifluo romethyl)-1H-pyrazol-1-yl]ethanone+TX, 1-[4-[4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3- Yl]-1,3-thiazol-2-yl]piperidin-1-yl]-2-[5-methyl-3-(trifluorom ethyl)-1H-pyrazol-1-yl]ethanone[1003318-67-9] (both are disclosed in WO 2010/123791, WO 2008/013925, WO 2008/013622 and WO 2011/051243, page 20) + TX, and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ( 3',4',5'-trifluoro-biphenyl-2-yl) -amide (disclosed in WO 2006/087343) + TX, S)-[3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-iso Zin-4-yl]-pyridin-3-ylmethanol+TX, 3-(4-chloro-2-fluorophenyl)-5-(2,4-difluorophenyl)-iso Zin-4-yl]-pyridin-3-ylmethanol+TX and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3',4',5'-pentafluoro Benz-2-yl)-guanamine (disclosed in WO 2006/087343) + TX, 3-(difluoromethyl)-N-methoxy-1-methyl-N-[1-methyl-2- The mixture of (2,4,6-trichlorophenyl)ethyl]-1H-pyrazole-4-carboxamide + TX, TX may also be in the form of an ester or a salt, such as "The Pesticide Manual" (Insecticide Manual, 12th Edition, 2000 (BCPC)).

In the above various active ingredients to be mixed with TX, the compound of formula I is preferably a compound of Tables 1 to 12, A, B, C and D; more preferably and even more preferably, selected from Tables 1 to 12. a compound of A, B; compound TX is selected from Table A, or compound TX is selected from Table B, or compound TX is selected from Table C, or compound TX is selected from Table D, and it is preferred that compound TX is selected from A1. A3, A4, A5, A6, A8, A9, A10, A11, A13, A15, A16, A17, A22, A23, A25, A28, A30, A31, A32, A33 to A36, A38 to A40, A45 to A51, A76, A56, A59, A77, A80, A82, A84, A85, A86, A87, A90, A91, A93, A94, A99, A101, A104, A105, A106, A111, A112, A115, A120, A122, A124, A126, A128, A129, A131, A132, 133, A134, A135, A136, A137, A138, A143, A144, A145, B1, B2, B3, B4, B5, B6, B7, B8, B9 and B10, or a compound TX is selected from the group consisting of A1, A2, A3, A4, A5, A8, A9, A10, A11, A13, A14, A15, A16, A17, A19, A20, A22, A23, A25, A30, A31, A32, A33, A34 , A36, A37, A38, A39, A40, A41, A42, A45, A46, A47, A48, A49, A50, A51, A76, A56, A57, A59, A61, A65, A68, A69, A72, A82, A86 , A90, A101, A112, A115, A126, A128, A129, A130, A131, A132, 133, A134, A135, A136, A137, A138, A139, A140, A142, A143, A144, A145, A146, A147, A149 , A151, A157, A158, A159, A167, A168, A178, A180, A181, A182 A183, A184, A186, A187, A188, A189, A190, A192, A195, A196, A197, A198, A199, B1, B2, B3, B4, B5, B6, B7, B8, B9 and B10, or compound TX From A1, A3, A4, A5, A6, A10, A12, A13, A15, A22, A23, A25, A28, A31, A32, A33, A34, A35, A36, A38, A39, A40, A41, A42, A45 , A46, A48, A49, A50, A51, A76, A56, A57, A59, A61, A79, A80, A83, A84, A86, A87, A90, A91, A93, A94, A95, A104, A106, A111, A112, A123, A126, A128, A129, A130, A131, A132, 133, A134, A135, A136, A137, A138, A142, A143, A144, A145, A146, A151, A157, A159, A163, A168, A178, A181, A182, A183, A184, A188, A189, A192, A195, A197, A199, B1, B2, B3, B4, B5, B6, B7, B8, B9 and B10, or compound TX is selected from the group consisting of A1, A2, A3, A4, A5, A6, A10, A11, A12, A23, A30, A32, A33, A34, A35, A38, A39, A40, A42, A45, A46, A48 , A49, A51, A76, A56, A57, A59, A61, A65, A68, A69, A80, A81, A82, A84, A87, A93, A101, A106, A109, A112, A115, A124, A126, A128, A129 , A131, A132, 133, A134, A135, A136, A137, A138, A143, A144, A145, A146, A151, A157, A158, A159, A168, A175, A178, A180, A181, A182, A183, A184, A188 , A189, A190, A191, A192, A195, A197, A198, A199, B1, B2, B3, B4, B5, B6, B7, B8 and B9, or the compound TX is selected from the group consisting of A1, A3, A4, A5, A6, A31, A45, A46, A48, A49, A76, A80 A81, A82, A86, A90, A100, A101, A109, A110, A115, A124, A126, A128, A129, A132, A136, A143, A144, A145, B3, B4, B5, B6, B7, B9 and B10, Or A6 or compound TX is selected from the group consisting of A4, A5, A10, A11, A23, A25, A33, A34, A36, A40, A42, A45, A46, A48, A49, A50, A56, A80, A82, A84, A86, A94 , A100, A101, A111, A112, A124, A126, A128, A132, A134, A137, A143, A168, B1, B2, B3, B4, B5, B6 and B9, or compound TX are selected from the group consisting of A46, A128, A132, A135, A137, B1, B2, B3, B4, B5, B9 and B10.

In a mixture of the above compounds of formula I (particularly selected from the compounds of Tables 1 to 12, A, B, C and D) with other insecticides, fungicides, herbicides, safeners, adjuvants and the like The mixing ratio can vary over a wide range and (preferably from 100:1 to 1:6000, especially from 50:1 to 1:50, more particularly from 20:1 to 1:20, even more particularly 10) : 1 to 1: 10. These ratios are understood to include, on the one hand, a weight ratio and, in addition, a molar ratio.

These mixtures can advantageously be used in the above formulations (in this case, the "active ingredient" system and TX are associated with each mixture of the mixed partners).

Some mixtures may contain active ingredients that have significantly different physical, chemical or biological properties such that they do not readily become the same type of conventional formulation. In these cases, other formulation types can be prepared. For example, when one active ingredient is a water-insoluble solid and the other is a water-insoluble liquid, it is still possible to disperse the active ingredients in the same continuous aqueous phase by dispersing the solid active ingredients. As a suspension (using a preparation similar to SC), the liquid active ingredient was dispersed as an emulsion (using a preparation similar to EW). The resulting composition is a suspension emulsion (SE) formulation.

A mixture comprising TX selected from Tables 1 to 12, A, B and C, and a mixture of one or more of the above active ingredients may be applied, for example, to a single "premixed" form for individual blending of single active ingredient elements. a combination spray mixture of materials (such as a "tank-mix"), and when used in a continuous manner, in a combined application of a single active ingredient, that is, in a reasonable short period of time (eg, Hours or days) apply one by one. Application selected from the table The order of the compounds of formula I from 1 to 12, A, B and C and the above-mentioned active ingredients is not critical to the action of the invention.

The compound of formula (I) can be mixed with soil, peat or other rooting agents to protect the plant from seed, soil or foliar fungal diseases.

Examples of synergists suitable for use in the composition include piperonyl butoxide, sesamex, safroxan, and dodecyl imidazole.

Herbicides and plant growth regulators suitable for inclusion in the composition will depend on the intended purpose and desired effect.

Porpanil is an example of a herbicide that can be incorporated into rice. And PIX ^TM is available for cotton plant growth regulator examples.

Some mixtures may contain active ingredients that have significantly different physical, chemical or biological properties such that they do not readily become the same type of conventional formulation. In these cases, other formulation types can be prepared. For example, when one active ingredient is a water-insoluble solid and the other is a water-insoluble liquid, it is still possible to disperse the active ingredients in the same continuous aqueous phase by dispersing the solid active ingredients. As a suspension (using a preparation similar to SC), the liquid active ingredient was dispersed as an emulsion (using a preparation similar to EW). The resulting composition is a suspension emulsion (SE) formulation.

Preparation example

Intermediate I1: 5-azido-1-methyl-3-pentafluoroethyl-4-trifluoromethyl-1H-pyrazole

5-Fluoro-1-methyl-3-pentafluoroethyl-4-trifluoromethyl-1H-pyrazole (according to "Russian Chemical Bulletin", 1990, 39, N° 11 , 2338 pages, 2 g; 7 mmol preparation) was added to a mixture of DMSO (10 ml) and sodium azide (0.5 g; 7.7 mmol) and added to the mixture (preserved at room temperature). The mixture was stirred overnight at room temperature. After the reaction was completed, a mixture of water (100 mL) and diethyl ether (100 mL) was added. The phases were separated and the aqueous phase was extracted twice with diethyl ether. This compound was used without additional purification.

Intermediate I2: D1: 3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3] Triazol-4-yl]-aniline

Ethynyl aniline (commercially available) and 5-azido-1-methyl-3-pentafluoroethyl-4-trifluoromethyl-1H-pyrazole (intermediate I1, 0.81 g, 2.6 mmol) were suspended In a mixture of water and t-BuOH (15 mL). Sodium ascorbate (0.300 ml of a 1 M aqueous solution, freshly prepared) was added to the mixture followed by copper sulfate pentahydrate (0.017 g). The resulting heterogeneous mixture was vigorously stirred for 96 hours. The reaction mixture was diluted with water and the product was extracted with ethyl acetate. The organic phase was washed with brine and dried over magnesium sulfate and evaporated. The desired product 3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-) was obtained from EtOAc EtOAc (EtOAc) Pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenylamine (Compound D1). ¹ H NMR (400 MHz, CDCl ₃ ): 8.01 (s, 1H), 7.32-7.19 (m, 2H), 6.75 (dd, 1H), 3.39 (s, 3H), 3.81 (s, 2H) ppm.

2-fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]tri Zizo-4-yl]-aniline (Compound D4) was prepared by the same method using 3-ethynyl-2-fluoro-aniline as a starting material.

¹ H NMR (400 MHz, CDCl ₃ ): 8.26 (d, 1H), 7.73 (t, 1H), 7.14 (t, 1H), 6.88 (t, 1H), 3.89 (s, 3H), 3.87 (bs, 2H) Ppm.

Intermediate I3: 4-ethynyl-2-nitro-benzonitrile

Will contain 25 mL of 4-bromo-2-nitrobenzonitrile (110.1 mmol), 25.2 ml of ethynyltrimethylnonane (178.4 mmol), 0.49 g of palladium acetate (2.2 mmol) and 1.16 g of triphenyl. A solution of phosphine (4.4 mmol) in dry triethylamine (300 mL) was quickly heated and refluxed in EtOAc overnight. The mixture was cooled and the crystalline white solid of triethylamine hydrobromide was isolated by filtration. The dark brown filtrate was concentrated, taken up in water (250 mL) aqueous The organic fraction was combined, dried over magnesium sulfate and concentrated to give an oil, which was dissolved in 200 ml of THF and treated with 300 ml of methanol and 450 mg of potassium carbonate. The mixture was stirred for one hour and concentrated. The concentrated solution was mixed with 250 mL of aqueous sodium bicarbonate and extracted with ethyl acetate (3×100 mL). The combined organic extracts were dried with MgSO4, EtOAcjjjjjjjjjjjjjjjjjjjjjj , 39% yield). ¹ H NMR (400 MHz, CDCl ₃ ): 8.40 (s, 1H), 7.89 (s, 2H), 3.5 (s, 1H) ppm.

Intermediate I4: C1: 4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3] Triazol-4-yl]-2-nitro-benzonitrile

4-ethynyl-2-nitro-benzonitrile (1.20 g, 1.07 mmol) and 5-azido-1-methyl-3-pentafluoroethyl-4-trifluoromethyl-1H-pyrazole ( Intermediate I1, 2.15 g, 7.0 mmol) were suspended in a mixture of water and t-BuOH (1:1, 30 mL). Sodium ascorbate (0.3 ml, 1 M solution in water, freshly prepared) was added to the mixture followed by copper sulfate pentahydrate (0.017 g). The resulting heterogeneous mixture was vigorously stirred at room temperature for 96 hours. The reaction mixture was diluted with water and cooled with an ice bath. The precipitated orange product was filtered and dried. The residue was purified by column chromatography (ethyl acetate: hexanes: 1:3) to give the desired product (Compound C1) (1.3 g, 40% yield). ¹ H NMR (400 MHz, CDCl ₃ ): 8.82 (s, 1H), 8.41 (d, 1H), 8.33 (s, 1H), 8.07 (d, 1H), 3.92 (s, 3H) ppm.

4-(4-Chloro-3-nitro-phenyl)-1-[2] was prepared in the same manner using 1-chloro-4-ethynyl-2-nitro-benzene (naphthalene) as a starting material. -Methyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazol-3-yl]triazole.

¹ H NMR (400 MHz, CDCl ₃ ): 8.40 (d, 1H), 8.23 (s, 1H), 8.10 (dd, 1H), 7.71 (d, 1H), 3.81 (s, 3H) ppm.

Intermediate I5: D2: 2-Amino-4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1 , 2,3]triazol-4-yl]-benzonitrile

Aqueous sodium hydroxide (0.1 M) (12.5 ml), sodium hydrogen sulfite (82%, 2.98 g, 14.0 mmol) and tetrabutylammonium bromide ("TBAB") (0.09 g, 0.3 mmol) were added to the 4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl a solution of 2-nitro-benzonitrile (Intermediate I5) (1.35 g, 2.8 mmol) in tetrahydrofurane (37.5 mL). The reaction mixture was stirred at room temperature for 2 hours. A mixture of water (100 mL) and ethyl acetate (100 mL) was added. The aqueous phase and the organic phase are separated. The aqueous phase was extracted twice with ethyl acetate. The combined organic extracts were dried over sodium sulfate and concentrated. The residue was purified by filtration on silica gel to give 2-amino-4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H -[1,2,3]Triazol-4-yl]-benzonitrile (Compound D2) (1.22 g, 96% yield). ¹ H NMR (400 MHz, CDCl ₃ ): 8.12 (s, 1H), 7.52 (d, 1H), 7.41 (s, 1H), 7.19 (d, 1H), 4.58 (sb, 2H), 3.88 (s, 3H) Ppm.

4-(2-Methoxy-3-nitrophenyl)-1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H was used. -[1,2,3]triazole as the starting material for the preparation of 2-methoxy-3-[1-(2-methyl-5-pentafluoroethyl-4-III) of Table D Fluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenylamine (Compound D5). ¹ H NMR (400 MHz, CDCl ₃ ): 8.4 (s, 1H), 7.68 (d, 1H), 7.11 (t, 1H), 6.83 (t, 1H), 3.92 (bs, 2H+3H), 3.71 (s, 3H) ppm.

Intermediate I6: D3: 2-chloro-5-[1-[2-methyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazole -3-yl]triazol-4-yl]aniline

Tin chloride (1.5 g, 6.6 mmol) was added to contain 4-(4-chloro-3-nitro-phenyl)-1-[2-methyl-5-(1,1, at ambient temperature 2,2,2-pentafluoroethyl A solution of 4-(trifluoromethyl)pyrazol-3-yl]triazole (Example I4) (0.90 g, 1.8 mmol) in isopropyl alcohol (6 mL). The mixture was cooled to 0 ° C and concentrated aqueous hydrochloric acid (1.5 mL) was slowly added. The reaction mixture was stirred at 80 ° C for 2 hours. Evaporate a third of the total amount of isopropanol. Water (100 ml) was added to the concentrated mixture, and aqueous sodium hydroxide (30%) was added to adjust the pH to 8 to 9. The aqueous phase was extracted three times with ethyl acetate (3 x 200 mL). The combined organic extracts were dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica (eluent: cyclohexane / ethyl acetate 2:1 to 1:1) to give 2-chloro-5-[1-[2-methyl- 5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazol-3-yl]triazol-4-yl]phenylamine (Compound D3) (0.67 g, 79% yield).

¹ H NMR (400 MHz, CDCl ₃ ): 8.01 (s, 1H), 7.40 (d, 1H), 7.35 (d, 1H), 7.14 (dd, 1H), 4.23 (bs, 2H), 3.87 (s, 3H) Ppm.

Example I 7.1: D6: ethyl-{2-fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H -[1,2,3]triazol-4-yl]-phenyl}-amine

2-Fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3] Zin-4-yl]-aniline (Compound D4) (0.200 g, 0.45 mmol) was dissolved in methanol (8 ml) and acetaldehyde (0.027 ml, 0.47 mmol) and acetic acid (0.03 ml, 0.54 mmol). Boron hydrocyanide (0.0368 g, 0.585 mmol) was then added in small amounts. The reaction mixture was stirred at room temperature for 1.2 hours. The mixture was diluted with aqueous sodium bicarbonate and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were dried over sodium sulfate and filtered and concentrated. The residue was purified by chromatography (eluent: cyclohexane / ethyl acetate) to give ethyl-{2-fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4) -Trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-amine (Compound D6) (0.170 g, 80%).

¹ H NMR (400 MHz, CDCl ₃ ): 8.21 (d, 1H), 7.72 (t, 1H), 7.19 (t, 1H), 6.29 (t, 1H), 3.93 (bs, 1H), 3.88 (s, 3H) , 3.27 (q, 2H), 1.34 (t, 3H) ppm.

Using 2-methoxy-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3 [2-methoxy-3-[Table D] is prepared by a similar method using triazol-4-yl]-aniline (Compound D5) as a starting material and using formaldehyde-containing water (~37.33% by mass) as a reagent. 1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)1H[1,2,3]triazol-4-yl]-phenyl} -Methylamine (Compound D7):

¹ H NMR (400 MHz, CDCl ₃ ): 8.48 (s, 1H), 7.61 (dd, 1H), 7.22 (t, 1H), 6.73 (dd, 1H), 4.32 (bs, 1H), 3.92 (s, 3H) , 3.68 (s, 3H), 2.92 (s, 3H) ppm.

Example P1: 4-cyano-N-{2-cyano-5-[1-(2-methyl-5-pentafluoroethyl-4-trifluoro Methyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-2-methyl-benzamide (Compound A1)

2-Methyl-4-cyanobenzamide chloride (0.1 g, 0.5 mmol, 2 eq.) and pyridine (0.064 Ml, 0.8 eq) were added to 2-amino-4-[1-(2- Methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-benzonitrile (Compound D2) In a solution of tetrahydrofuran (5 mL). The mixture was stirred at room temperature overnight. Next, the mixture was dissolved in a mixture of ethyl acetate and water. The organic layer and the aqueous layer were separated, then the aqueous phase was extracted twice with ethyl acetate. The organic phase was combined and dried over sodium sulfate, and the solvent was evaporated in vacuo. The residue was purified by column chromatography (cyclohexane:ethyl acetate: 3:1) to afford 4-cyan-N-{2-cyan-5-[1-(2-methyl-5-pentafluoro Ethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-2-methyl-benzamide (Compound A1) (0.1 g, 63% yield). ¹ H NMR (400 MHz, CDCl ₃ ): 9.05 (s, 1H), 8.30 (s, 1H), 8.03 (s, 1H), 7.97 (d, 1H), 7.81 (d, 1H), 7.70 (d, 1H) , 7.64 (m, 2H), 3.89 (s, 3H), 2.60 (s, 3H) ppm.

2-Amino-4-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3] was used. Triazol-4-yl]-benzonitrile (Compound D2) or 3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)- 1H-[1,2,3]triazol-4-yl]-phenylamine (Compound C1) or 2-Chloro-5-[1-[2- Methyl-5-(1,1,2,2,2-pentafluoroethyl)-4-(trifluoromethyl)pyrazol-3-yl]triazol-4-yl]phenylamine (Compound D3) or 2-fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazole 4-yl]-aniline (Compound D4) or 2-methoxy-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazole-3- -1H-[1,2,3]triazol-4-yl]-phenylamine (Compound D5) or Ethyl-{2-Fluoro-3-[1-(2-methyl-5-pentafluoroethyl) Benzyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-amine (Compound D6) or {2-A Oxy-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)1H[1,2,3]triazole-4- Preparation of A2 to A6 and A76, A126 to A131, 133 to 141, and B1 to B8 in Table B in Table A by the same or similar method using as a starting material. compound of.

Example P2: General Method for Parallel Deuteration of Aminobenzamide

Aminobenzamide (0.78 mmol) was dissolved in toluene (15.6 ml) (for example, 3-[1-(2-methyl-5-pentafluoroethyl-4-) in the compound A7 example of Table A Trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenylamine (Compound D1) to prepare solution A in toluene (8 ml) The B solution was prepared by dissolving ruthenium chloride (1.0 mol) (for example, 2-fluoro-benzimid chloride in the example of the compound of Table A No. A7).

Place the A solution (0.6ml, 30μmol) in the well of the well plate and add it in order. Solution B (0.3 ml, 36 μmol) and diisopropylethylamine (Hunig's Base) (30 μl, 150 μmol). The mixture was stirred at 70 ° C overnight. The mixture was diluted with a mixture of acetonitrile (0.6 ml) and N,N-dimethylacetamide (0.2 ml), followed by purification by HPLC to give the desired compound, for example: 2-fluoro-N-{3-[ 1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-benzene Benzoyl-benzamide (Compound A7).

This general method or a similar method is used to prepare some of the compounds of Table A (Compound Nos. A7 to A75, A77 to A125 and A146 to A200) using 2-amino-4-[1-(2-methyl) 5-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-benzonitrile (Compound D2) or 3 -[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl] -aniline (compound D1) or 2-chloro-5-[1-[2-methyl-5-(pentafluoroethyl 1)-4-(trifluoromethyl)pyrazol-3-yl]triazole- 4-yl]aniline (compound D3) or 2-fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H -[1,2,3]Triazol-4-yl]-phenylamine (Compound D4) was used as a starting material.

Example P3: N -{2-Fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1 ,2,3]triazol-4-yl]-phenyl}-1-oxy-isonicotinamide (Compound A132)

N-{2-Fluoro-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2, 3] Triazol-4-yl]-phenyl}-isonicotinamine amide (Compound A128) (0.050 g, 0.1125 mmol) was dissolved in dichloromethane (2 ml) and 3-chloroperoxybenzoic acid was added ( 0.0261 g, 0.1463 mmol). After stirring at room temperature for 4 hours, the mixture was diluted with dichloromethane, and aqueous sodium hydroxide solution was added. The phases were separated, EtOAc (EtOAc m.) Melting point 227-229 ° C. ^{1 H-NMR (400MHz, CDCl} 3): 8.44 (t, 1H), 8.22 (d, 2H), 8.17 (d, 1H), 8.09 (t, 1H), 7.97 (bs, 1H), 7.71 (d, 2H), 7.32 (t, 1H), 3.82 (s, 3H) ppm.

Compounds A142 to A143 of Table A and Compounds B9 to B10 of Table B were prepared in the same manner.

Example P4: 2,4,6-Trifluoro-N-{2-methoxy-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyridyl) Zyrid-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-benzamide (Compound A144)

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI, 0.0429 g, 0.217 mol), 1-hydroxy-7-azobenzotriazole (HOAT) , 0.0301 g, 0.217 mol), triethylamine (0.056 ml, 0.394 mmol) and 2,4,6-trifluorobenzoic acid (39 mg, 0.217 mmol) were added to 2-methoxy-3-[1-( 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenylamine (Compound D5 (0.09 g, 0.197 mmol) in dichloromethane (4 mL). The mixture was stirred at room temperature overnight (19 hours). Next, the mixture was diluted with dichloromethane and sodium hydrogencarbonate was added. The organic layer and the aqueous layer were separated, and then the organic phase was extracted with aqueous sodium hydroxide. The organic phase was dried by sodium sulfate and filtered, and the solvent was evaporated in vacuo. The residue was purified by column chromatography (cyclohexane: ethyl acetate) to give 2,4,6-trifluoro-N-{2-methoxy-3-[1-(2-methyl- 5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-benzamide ( Compound A144) (0.038 g, 32% yield). ¹ H NMR (400 MHz, CDCl ₃ ): 8.49 (dd, 1H), 8.28 (s, 1H), 8.19 (bs, 1H), 7.78 (dd, 1H), 7.29 (t, 1H), 6.75 (t, 2H) , 3.87 (s, 3H), 3.63 (s, 3H) ppm.

Compounds A145 and A201 of Table A were prepared in the same manner.

Example P5: 2,4,6-Trifluoro-N-{2-methoxy-3-[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyridyl) Zyrid-3-yl)-1H-[1,2,3]triazole-4- Base]-phenyl}-N-methyl-benzamide (Compound B11)

Triethylamine (0.060 ml, 0.425 mmol), 2,4,6-trifluorobenzoic acid (46 mg, 0.255 mmol) and BOP-Cl (0.167 g, 0.638 mmol) were added to contain {2-methoxy-3 -[1-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)1H[1,2,3]triazol-4-yl]-benzene A solution of methylamine-methylamine (Compound D7) (0.1 g, 213 mmol) in 1,2-dichloroethane (3 mL). The mixture was stirred under reflux for 15 hours. Next, the mixture was diluted with dichloromethane and sodium hydrogencarbonate was added. The organic layer and the aqueous layer were separated, and then the organic phase was extracted with brine. The organic phase was dried over sodium sulfate and filtered, and the solvent evaporated in vacuo. The residue was purified by column chromatography (cyclohexane: ethyl acetate) to give 2,4,6-trifluoro-N-{2-methoxy-3-[1-(2-methyl- 5-Pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-1H-[1,2,3]triazol-4-yl]-phenyl}-N-methyl- Benzamide (Compound B11) (0.045 g, 34% yield).

¹ H NMR (400 MHz, CDCl ₃ ): 8.20 (d, 1H), 8.17 (s, 1H), 7.45 (d, 1H), 6.82 (t, 1H), 6.52 (bs, 1H), 6.38 (bs, 1H) , 3.90 (s, 3H), 3.78 (s, 3H), 3.58 (s, 3H) ppm. In addition, the range contains the peaks of the rotamer.

Method A:

LC-MS method (positive or negative) for compounds A1 to A7, C1, D1 and D2:

American Waters ZQ mass spectrometer (single quadrupole mass spectrometer)

Instrument parameters:

Ionization method: electric spraying

Polarity: positive ion

Capillary (kV) 3.00, injection cone (V) 30.00, extractor (V) 2.00, source temperature (°C) 100, desolvation gas temperature (°C) 250, injection cone gas flow rate (L/Hr) 50, off Solvent gas flow rate (L/Hr) 400

Quality range: 100 to 900Da

Agilent's HP 1100 HPLC: solvent deaerator, quaternary pump (ZCQ) / binary pump, heated oven and diode array detector.

Column: Fernome Gemini C18, 3mm, 30x3mm, temperature: 60 ° C

DAD wavelength range (nm): 200 to 500

Solvent gradient:

A=water+0.05%HCOOH

B = acetonitrile / methanol (4:1, v: v) + 0.04% HCOOH

Method B:

LC-MS method for the application of compounds A7 to A75, A77 to A125 and A146 to A200 (positive):

American Waters ACQUITY SQD Mass Spectrometer (Single Quadrupole Mass Spectrometer)

Ionization method: electrospray, polarity: positive ion, capillary (kV) 3.00, injection cone (V) 20.00, extractor (V) 3.00, source temperature (°C) 150, desolvation gas temperature (°C) 400, into Cone gas flow rate (L/Hr) 60, desolvation gas flow rate (L/Hr) 700

Mass range: 100 to 800 Da, DAD wavelength range (nm): 210 to 400

American Waters ACQUITY UPLC Method with the following HPLC Gradient Conditions

(A solvent: water/methanol 9:1, 0.1% formic acid and B solvent: acetonitrile, 0.1% formic acid)

Column type: American Waters ACQUITY UPLC HSS T3; column length: 30mm; column inner diameter: 2.1mm; particle size: 1.8 micro Rice; temperature: 60 ° C.

C method:

LC-MS method (positive/negative) for the compounds A126 to A139, A141 to A145, B1 to B11, C2 to C3, D3 to D7:

American Waters ZQ mass spectrometer (single quadrupole mass spectrometer)

Instrument parameters: ionization method: electrospray, polarity: positive and negative ions

Capillary: 3.00kV, injection cone: 30.00V, extractor: 2.00V, source temperature: 100 ° C, desolvation gas temperature: 250 ° C, injection cone gas flow rate: 50 L / Hr, desolvation gas flow rate: 400 L / Hr , mass range: 100 to 900Da

Agilent's HP 1100 HPLC:

Solvent degassing agent, binary pump, heating oven and diode array detector. Column: Fernome Gemini C18, 3mm, 30x3 mm, temperature: 60 ° C, DAD wavelength range (nm): 210 to 500

Solvent gradient:

A=H2O+5% MeOH+0.05%HCOOH

B = acetonitrile + 0.05% HCOOH

D method:

LC-MS method (positive/negative) for compounds A140 and A143:

American Waters SQD mass spectrometer (single quadrupole mass spectrometer)

Instrument parameters: ionization method: electric spraying, polarity: positive ion and negative ion, capillary: 3.00kV, injection cone: 30.00V, extractor: 2.00V, source temperature: 150 °C, desolvation gas temperature: 250 °C, advance Cone gas flow rate: 0L/Hr, desolvation gas flow rate: 650L/Hr, mass range: 100 to 900Da

Acquity UPLC from Waters:

Binary pump, heated oven and diode array detector.

Solvent degassing agent, binary pump, heating oven and diode array detector.

Column: Fernome Gemini C18, 3 mm, 30 x 2 mm, temperature: 60 ° C

DAD wavelength range (nm): 210 to 500

Solvent gradient:

A=H2O+5% MeOH+0.05%HCOOH

B = acetonitrile + 0.05% HCOOH

Biological example

This method of demonstrating the insecticidal properties of the compounds of formula (I) is carried out as follows:

Egyptian cotton leaf worm ( Spodoptera littoralis ):

The cotton leaf disc was placed on agar in a 24-well microtiter plate and sprayed with the test solution at an application rate of 200 ppm. After drying, the leaf discs were infected with 5 L1 larvae. After 3 days of treatment (DAT), samples were examined for mortality, feeding behavior, and growth regulation.

The following compounds produce at least 80% control of the Egyptian cotton leaf worm ( Sodoptera littoralis ): A1, A3, A4, A5, A6, A8, A9, A10, A11, A13, A15, A16, A17, A22, A23, A25, A28, A30, A31, A32, A33 to A36, A38 to A40, A45 to A51, A76, A56, A59, A77, A80, A82, A84, A85, A86, A87, A90, A91, A93, A94, A99, A101, A104, A105, A106, A111, A112, A115, A120, A122, A124, A126, A128, A129, A131, A132, 133, A134, A135, A136, A137, A138, A143, A144, A145, B1 B2, B3, B4, B5, B6, B7, B8, B9, B10.

Heliothis virescens:

The eggs (aged age: 0 to 24 hours) were placed on the artificial feed in a 24-well microtiter plate, and the test solution was applied to the eggs at a rate of 200 ppm using a pipette suction method (the concentration in the well was 18pm). After 4 days After the incubation period, the samples were examined for egg mortality, larval mortality, and growth regulation.

The following compounds produce at least 80% control of Heliothis virescens: A1, A2, A3, A4, A5, A8, A9, A10, A11, A13, A14, A15, A16, A17, A19, A20, A22 , A23, A25, A30, A31, A32, A33, A34, A36, A37, A38, A39, A40, A41, A42, A45, A46, A47, A48, A49, A50, A51, A76, A56, A57, A59 , A61, A65, A68, A69, A72, A82, A86, A90, A101, A112, A115, A126, A128, A129, A130, A131, A132, 133, A134, A135, A136, A137, A138, A139, A140 , A142, A143, A144, A145, A146, A147, A149, A151, A157, A158, A159, A167, A168, A178, A180, A181, A182, A183, A184, A186, A187, A188, A189, A190, A192 , A195, A196, A197, A198, A199, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10.

Plutella xylostella:

The test solution (concentration in the well was 18 ppm) was applied at a rate of 200 ppm in a 24-well microtiter plate (MTP) containing artificial feed by pipetting. After drying, the L2 larvae were parasitic on the MTP (7 to 12 per well). After a 6-day incubation period, samples were examined for larval mortality and growth regulation.

The following compounds produce at least 80% control of Plutella xylostella: A1, A3, A4, A5, A6, A10, A12, A13, A15, A22, A23, A25, A28, A31, A32, A33, A34, A35, A36, A38, A39, A40, A41, A42, A45, A46, A48, A49, A50, A51, A76, A56, A57, A59, A61, A79, A80, A83, A84, A86, A87, A90, A91, A93, A94, A95, A104, A106, A111, A112, A123, A126, A128, A129, A130, A131, A132, 133, A134, A135, A136, A137, A138, A142, A143, A144, A145, A146, A151, A157, A159, A163, A168, A178, A181, A182, A183, A184, A188, A189, A192, A195, A197, A199, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10.

Corn rootworm (Diabrotica balteata):

The test solution (concentration in the well was 18 ppm) was applied at a rate of 200 ppm in a 24-well microtiter plate (MTP) containing artificial diet by pipetting. After drying, the L2 larvae are parasitic on the MTP (6 to 10 per well). After a 5-day incubation period, the samples were examined for larval mortality and growth regulation.

The following compounds produce at least 80% control of the corn rootworm (Diabrotica balteata): A1, A2, A3, A4, A5, A6, A10, A11, A12, A23, A30, A32, A33, A34, A35, A38, A39 , A40, A42, A45, A46, A48, A49, A51, A76, A56, A57, A59, A61, A65, A68, A69, A80, A81, A82, A84, A87, A93, A101, A106, A109, A112 , A115, A124, A126, A128, A129, A131, A132, 133, A134, A135, A136, A137, A138, A143, A144, A145, A146, A151, A157, A158, A159, A168, A175, A178, A180, A181, A182, A183, A184, A188, A189, A190, A191, A192, A195, A197, A198, A199, B1 B2, B3, B4, B5, B6, B7, B8, B9.

Tetranychus urticae:

The bean leaf dish on the agar was sprayed with the test solution in a 24-well microtiter plate at an application rate of 200 ppm. After drying, the leaf discs parasitize the cockroaches of different ages. After 8 days, these dishes were examined for egg mortality, larval mortality, and adult mortality.

The following compounds produce at least 80% control of Tetranychus urticae: A1, A3, A4, A5, A6, A31, A45, A46, A48, A49, A76, A80, A81, A82, A86, A90, A100, A101, A109, A110, A115, A124, A126, A128, A129, A132, A136, A143, A144, A145, B3, B4, B5, B6, B7, B9, B10.

Thrips tabaci:

The sunflower leaf discs were placed on agar in a 24-well microtiter plate and sprayed with the test solution at an application rate of 200 ppm. After drying, the leaf discs parasitize the locust swarms of different ages. After a 7-day incubation period, the samples were examined for mortality.

The following compounds produce at least 80% control of Thrips tabaci: A4, A5, A10, A11, A23, A25, A33, A34, A36, A40, A42, A45, A46, A48, A49, A50, A56, A80, A82, A84, A86, A94, A100, A101, A111, A112, A124, A126, A128, A132, A134, A137, A143, A168, B1, B2, B3, B4, B5, B6, B9.

Myzus persicae:

The sunflower leaf discs were placed on agar in a 24-well microtiter plate and sprayed with the test solution at an application rate of 200 ppm. After drying, the leaf discs parasitize the locust swarms of different ages. After a 6-day incubation period, the samples were examined for mortality.

The following compounds produced at least 80% control of Myzus persicae: A46, A128, A132, A135, A137, B1, B2, B3, B4, B5, B9, B10.

Claims (12)

a compound of formula (I) Wherein A ¹ , A ² , A ³ and A ⁴ are each independently CX or nitrogen, wherein each X may be the same or different; R ¹ is hydrogen, C ₁ -C ₄ alkyl, H ₂ NC(O)- C ₁ -C ₄ alkyl or C ₁ -C ₄ alkylcarbonyl; R ² is hydrogen, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₆ haloalkyl or cyano; G ¹ is oxygen or sulfur X is hydrogen, halogen, cyano, C ₁ -C ₄ alkoxy, C ₁ -C ₄ alkyl or C ₁ -C ₄ haloalkyl; Q ¹ is aryl or heterocyclic, each optionally substituted by one to five R ³ substituents, such substituents may be the same or different; or Q ¹ is C ₁ -C ₈ alkyl or substituted by one to five R ⁴ C ₁ -C ₈ alkyl, C ₂ -C ₈ alkenyl group or by one to five R ⁴ is a substituted C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or ₂ -C ₈ alkynyl group substituted by one to five R is C ^4, C ₃ -C ₁₀ cycloalkyl or C ₃ -C ₁₀ cycloalkyl substituted by one to five R ⁴ ; R ³ is selected from the group consisting of cyano, amine, nitro, hydroxy, halogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ haloalkyl, C ₂ -C ₄ alkenyl, C ₂ -C ₄ haloalkenyl, C ₂ -C ₄ alkynyl, C ₂ -C ₄ haloalkynyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, C ₁ -C ₃ alkoxy, C ₁ -C ₃ haloalkoxy, C ₁ -C ₃ alkylthio, C ₁ -C ₃ haloalkylthio, C ₁ -C ₃ alkylsulfinyl, C ₁ -C ₃ haloalkylsulfinyl, C ₁ -C ₃ alkylsulfonyl, C ₁ -C ₃ halo Alkylsulfonyl, C ₁ -C ₄ alkylamino, bis(C ₁ -C ₄ alkyl)amino, C ₁ -C ₄ alkylcarbonyl, C ₁ -C ₄ alkylcarbonyloxy, C ₁ -C ₄ alkoxycarbonyl, C ₁ -C ₄ alkylcarbonylamino and phenyl; R ^{4 are} each independently halogen, cyano, nitro, hydroxy, C ₁ -C ₈ alkoxy, C ₁ -C ₈ haloalkoxy, C ₁ -C ₈ alkylthio, C ₁ -C ₈ haloalkylthio, C ₁ -C ₈ alkylsulfinyl, C ₁ -C ₈ haloalkylsulfinium a C ₁ -C ₈ alkylsulfonyl group, a C ₁ -C ₈ haloalkylsulfonyl group, a C ₁ -C ₈ alkylcarbonyl group, a C ₁ -C ₈ alkoxycarbonyl group, an aryl group or from one to five R ³ substituted aryl, or heterocyclic group or heterocyclic group substituted by one to five R ³ ; Q ² is a moiety having formula (II) Wherein R ⁷ and R ⁶ are each independently hydrogen, cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₄ alkoxy-C ₁ -C ₄ -alkyl , C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ -C ₆ haloalkylsulfinyl, C ₁ -C ₆ Alkylsulfonyl or C ₁ -C ₆ haloalkylsulfonyl; R ^{5 is} independently hydrogen, hydroxy, amine, NC ₁ -C ₆ alkylamino, N,N-di-(C ₁ -C ₆ alkyl)amino, C ₁ -C ₆ alkyl, C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ alkynyl, substituted by one to five substituents R ⁹ C ₁ -C ₆ alkyl group, by one to five substituents R ⁹ is a substituted C ₃ -C ₆ cycloalkyl, C ₂ -C ₆ alkynyl group substituted by one to five substituents R ^9, substituted by one to five a C ₂ -C ₆ alkenyl group substituted by a radical R ⁹ , an aryl group or an aryl group substituted with one to five substituents R ¹⁰ , a heteroaryl group or a heteroaryl group substituted by one to five substituents R ¹⁰ , each of R ⁹ Independent of cyano, nitro, amine, hydroxy, halogen, NC ₁ -C ₆ alkylamino, N,N-di-(C ₁ -C ₆ alkyl)amine, C ₁ -C ₆ alkane alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ alkylsulfinyl acyl, aryl, or by one to five independent Selected from cyano, nitro, hydroxy, halo, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkoxy or C ₁ -C ₆ haloalkoxy substituent group Substituted aryl, or heteroaryl or from one to five independently selected from cyano, nitro, hydroxy, halo, C ₁ -C ₆ alkyl, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ a heteroaryl group substituted with a substituent of an alkoxy group or a C ₁ -C ₆ haloalkoxy group; R ^{10 is} independently a cyano group, a nitro group, an amine group, a hydroxyl group, a halogen, a C ₁ -C ₆ alkyl group, C _1- C ₆ haloalkyl, C ₁ -C ₄ alkoxy-C ₁ -C ₄ -alkyl, C ₂ -C ₆ alkenyl, C ₂ -C ₆ haloalkenyl, C ₂ -C ₆ alkynyl , C ₂ -C ₆ haloalkynyl, C ₃ -C ₆ cycloalkyl, C ₃ -C ₆ halocycloalkyl, C ₁ -C ₆ alkoxy, C ₁ -C ₆ haloalkoxy, C ₁ -C ₄ alkoxy-C ₁ -C ₄ alkoxy, C ₁ -C ₆ alkylthio, C ₁ -C ₆ haloalkylthio, C ₁ -C ₆ alkylsulfinyl, C ₁ - C ₆ haloalkylsulfinyl, C ₁ -C ₆ alkylsulfonyl, C ₁ -C ₆ haloalkylsulfonyl, N- C ₁ -C ₆ alkylamino, N , N - II -(C ₁ -C ₆ alkyl)amino, N , N -di-(C ₁ -C ₆ alkyl)aminocarbonyl, N,N-di-(C ₁ -C ₆ alkyl)amine sulfonate acyl, C ₁ -C ₆ alkyl Group, C ₁ -C ₆ alkylcarbonyloxy, C ₁ -C ₆ alkoxycarbonyl, C ₁ -C ₆ alkylcarbonyl group; or a agrochemically acceptable salt or N- oxide. The compound according to claim 1, wherein A ¹ , A ² , A ³ and A ⁴ are CX, and each X is independently selected from the group consisting of hydrogen, halogen, cyano, methyl, trifluoromethyl and Methoxy. A compound according to the second aspect of the patent application, characterized in that R ¹ is hydrogen, methyl, ethyl or ethoxylated; R ² is hydrogen, methyl, trifluoromethyl or halogen; G ¹ is oxygen; ¹ is aryl or heteroaryl; each optionally from one to five independently selected from cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, trifluoromethyl, methoxy, tri Substituted with a substituent of a fluoromethoxy group, a methylthio group, a sulfinyl group, a methanesulfonyl group and a phenyl group; R ⁵ is hydrogen, a C ₁ -C ₆ haloalkyl group, a C ₁ -C ₆ alkyl group, C _2- C ₆ alkenyl, C ₂ -C ₆ alkynyl, phenyl or phenyl, pyridyl or one to five, which may be the same or different, may be substituted by one to five R ¹⁰ substituents which may be the same or different. R ¹⁰ substituent-substituted pyridyl; R ⁷ and R ^{6 are} independently hydrogen, cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ perfluoroalkyl, C ₁ -C ₆ perfluoroalkane Sulfhydryl, C ₁ -C ₆ perfluoroalkylsulfinyl or C ₁ -C ₆ -perfluoroalkylsulfonyl, preferably independently C ₁ -C ₄ perfluoroalkyl, C ₁ -C ₄ Perfluoroalkylthio, C ₁ -C ₄ -perfluoroalkylsulfinyl or C ₁ -C ₄ -perfluoroalkylsulfonyl, even more preferably independently C ₁ -C ₄ a perfluoroalkyl group, a C ₁ -C ₄ -perfluoroalkylthio group or a C ₁ -C ₄ -perfluoroalkylsulfonyl group; A compound according to item 3 of the patent application, characterized in that R ¹ is hydrogen, methyl or ethyl; R ² is hydrogen, trifluoromethyl or halogen; Q ¹ is phenyl, pyridyl, furyl, thiophene Or pyrazolyl or 1,2,3-thiadiazolyl; each optionally from one to four independently selected from the group consisting of cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, trifluoro Substituted by a substituent of methyl, methoxy, trifluoromethoxy, methylthio, sulfinyl, methanesulfonyl and phenyl; R ⁵ is hydrogen, C ₁ -C ₆ haloalkyl, C ₁ -C ₆ alkyl; R ⁷ and R ^{6 are} independently cyano, halogen, C ₁ -C ₆ alkyl, C ₁ -C ₆ -perfluoroalkyl; A compound according to item 4 of the patent application, characterized in that R ¹ is hydrogen; R ² is hydrogen or halogen; Q ¹ is phenyl, pyridyl or pyrazolyl; each of which is optionally independently selected from one to four Cyano, nitro, hydroxy, bromo, chloro, fluoro, methyl, ethyl, trifluoromethyl, methoxy, trifluoromethoxy, methylthio, sulfinyl, methyl sulfonate Substituted with a substituent of a fluorenyl group and a phenyl group; R ^{5 is} preferably a C ₁ -C ₄ alkyl group; and R ⁷ and R ^{6 are} independently a C ₁ -C ₆ -perfluoroalkyl group; A compound according to claim 5, wherein R ² is hydrogen Q ¹ is phenyl or pyridyl; each of which is optionally independently selected from the group consisting of a cyano group, a nitro group, a chloro group, a fluoro group, a methyl group, One, two or three substituents of ethyl, trifluoromethyl, methoxy and trifluoromethoxy are substituted. A compound according to the first aspect of the invention, wherein Q ² is 2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl. A compound according to the first aspect of the patent application, characterized in that Q ¹ is a C ₁ -C ₈ alkyl group or a C ₁ -C ₈ alkyl group substituted by one to five R ⁴ , a C ₂ -C ₈ alkenyl group or substituted by one to five R ⁴ is C ₂ -C ₈ alkenyl, C ₂ -C ₈ alkynyl group or substituted by one to five R is C ⁴ ₂ -C ₈ alkynyl, C ₃ -C ₁₀ cycloalkyl or by one to Five R ⁴ -substituted C ₃ -C ₁₀ cycloalkyl groups, and each R ^{4 is} independently halogen, cyano, nitro, hydroxy, C ₁ -C ₈ alkoxy-, C ₁ -C ₈ haloalkoxy Base-, C ₁ -C ₈ alkylthio-, C ₁ -C ₈ haloalkylthio-, C ₁ -C ₈ alkylsulfinyl-, C ₁ -C ₈ haloalkylsulfinyl- , C ₁ -C ₈ alkylsulfonyl-, C ₁ -C ₈ haloalkylsulfonyl-, C ₁ -C ₈ alkylcarbonyl-, C ₁ -C ₈ alkoxycarbonyl-, aryl or An aryl group substituted with one to five R ³ or a heterocyclic group or a heterocyclic group substituted with one to five R ³ . a compound of formula (III) Wherein A ¹ , A ² , A ³ , A ⁴ , R ² and Q ² are as defined for formula (I); or a salt thereof. a compound of formula (IIIb) Wherein A ¹ , A ² , A ³ , A ⁴ , R ² and Q ² are as defined for formula (I); or a salt thereof. A method of combating and controlling insects, mites, nematodes or molluscs comprising an insecticidal, acaricidal, nematicidal or molluscicidal effective amount as defined in any one of claims 1 to 8 of the patent application (I) The compound is applied to a pest, a pest, or a plant or plant propagation material that is susceptible to pests. An insecticidal, acaricidal or nematicidal composition comprising an insecticidal, acaricidal or nematicidally effective amount of a compound of formula (I) as defined in any one of claims 1 to 8.