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TW201221135A - Treatment of female diseases, menstrual pain composition of herbal extract concentrated - Google Patents

Treatment of female diseases, menstrual pain composition of herbal extract concentrated Download PDF

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Publication number
TW201221135A
TW201221135A TW99141155A TW99141155A TW201221135A TW 201221135 A TW201221135 A TW 201221135A TW 99141155 A TW99141155 A TW 99141155A TW 99141155 A TW99141155 A TW 99141155A TW 201221135 A TW201221135 A TW 201221135A
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TW
Taiwan
Prior art keywords
pain
menstrual
composition
menstrual pain
treatment
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Application number
TW99141155A
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Chinese (zh)
Inventor
Jian-Rung Cheng
Original Assignee
Jian-Rung Cheng
Jhan Yu Biotech Inc
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Application filed by Jian-Rung Cheng, Jhan Yu Biotech Inc filed Critical Jian-Rung Cheng
Priority to TW99141155A priority Critical patent/TW201221135A/en
Publication of TW201221135A publication Critical patent/TW201221135A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides treatment of women with menstrual pain disorders herbal extract concentrated composition, dedicated to the treatment of women with menstrual pain syndrome disease, the general type of menstrual pain, menstrual pain, and other special type fibroids herbal extracted concentrated composition, which composition includes a Radix Angelica sinensis, Ramulus Cinnamomumi, Semen persicae, Rhizoma Corydalis, Cortex Moutan, Radix Achyranthes bidentata, Rhizoma Chuanxiong, Flos carthami, Radix Paeonia alba, Faeces trogopterori, Cortex Cinnamomumi, Radix Paeonia rubra, Pollen Typhae, Myrrha, Fructus Foeniculi, Rhizoma Zingiberis, Poria, Pericarpium Arecae, Radix Angelicae dahuricae, Folium Perillae, Pericarpium Citri reticulatae, Radix Platycodonis, Rhizoma Atractylodis macrocephalae, Cortex Magnoliae officinalis, Rhizoma Pinelliae, Radix Glycyrrhiza, Herba Pogostemonis, Rhizoma Zingiberis recens, Fructus jujube etc., depending on the extent of women by the needs of pathological pain syndrome, the use of pharmacological properties, group effect synthesis of two different formulations of the composition, dedicated to the treatment of female diseases, menstrual pain syndrome disease extract concentration of food, health food or medicine.

Description

201221135 六、發明說明: 【發明所屬之技術領域】 本發明係提供治療女性經痛疾病的中草藥萃取濃縮板合物,運用本發明 中草藥萃取濃縮組合物_特性,肋治療女性生理期前、巾、%失調產& 的經痛症候群,包含月經頭痛、眩暈、經痛、勝痛或月經血塊、量少、閉經 及月經提前、延後、月經感冒、情緒障礙及預防子宮肌瘤或卵巢巧克力囊腫、 腫瘤產生等’女性生理期經痛症候群相的食品、保健食品或藥品。 【先前技術】 女性生理期前、中、後失調,造成經痛症候群原因與目前治療方法: 古代醫學㈣鱗科簡的撕仰說是相#嚴謹, 相當多’造成經痛原因包括:沒有發育成熟或飲食生冷,為外因六淫(風、 暑、濕、燥、寒、火)滯留於體内化熱、發炎引起經痛症候群,現在的女性 不像古雜的女子生理躺大、二門不_鱗_,縣的女性不 僅要接受正規的教育,在職場還要伯有一席之地,必須承接學業上或工作上 的壓力’對生理週補響甚大,常在不自覺中,傷害自己的身體;尤其在生 理期中’不正當驗飾1生利觸雜的傷害更大。生財清早上起床, 匆忙喝杯冰牛城優_^上班,辦公室触整冷氣:件為了減肥, 吃了生菜沙拉雜一杯加冰的無糖飲料;下班後和朋友相約到健身中心游 泳、SPA,如果剛好碰上月經來,有方便的衛生棉條救急,就算下水游泳也 不擔心Μ外流;回紐,要在職的夏夜娜好咖覺必歧冷氣吹整 仪’導致子宮或即巢有氣滯血癖功能失調’引起痛經、血塊、月經不規則、 腰痛、頭痛或情緒障礙等症狀。 生理期荷爾蒙失調經痛症候群: m體内擁有獨制荷聽聊,生翊來轉,祕荷爾蒙分 泌’身體si為血液或其他雜揚侧而錢化,從生理麟触理期中, 201221135 女性體内正上演著-場荷爾蒙的非常動|匕期,這些荷聽的中樞是腦下垂 體,释腦下垂體的視床下部,為自律神經的中梅所在,當荷爾蒙變化時, 自律神經會受影響而錯IL;自律神經掌管不受人為意志所控制的神經系統, 例如血液循環.、體溫的調節、ϋ官功能的運作等,而當此神經系騷不協調 狀態時,便會產生頭痛、目眩、想吐、手腳發冷、失眠、_寡歡等症狀, 是造成生理期種種不適症狀的最大原因。 女性不止會經痛,也會出麟謂的經前症候群。經前症候群泛指月經來 所有不舒服錄’包括乳絲痛、情緒不歡、脾絲縣乏对 性、水腫、頭痛、職背痛、腹痛、食懲過盛或減少,甚至睡眠障礙等影響 中樞神經系統。所以小姐或太太旁邊的男伴如不瞭解女生躺月的生理週期 ,響身心的諸錢化,可能因此常常遭白眼,或莫名其妙的挨了一頓罵,那 是因為女方的月經即將來臨或正處於生理週期甲。 生理期失調腹痛的原因是荷爾蒙導致的子宮收縮,藉由子宮的收縮,將 剝落的子宮内膜與經峋出體外。其原理大致與生產相似—收縮子宮,引起 陣痛:而生理期也會因子宮的收縮而產生相_疼痛感,會造成腸胃收縮; 疋兇是身體崎娜。女騎身體細卩後至下次胸秘這段期間 黃體期’在黃體期時黃細蒙會急速增加哪又迅速下降。而荷爾蒙的 中樞位於烟見床下部’與自律神經中枢的位置相同;所以— 變化,自律神經的協縱會受至爾,身心狀況也隨之陷入—片混亂;頻 荷爾蒙為加厚子宮内膜’控制了腸的蠕動造成腹填,相對地,在= 易便溺的原因;這種促進子宮收縮的「子宮收縮荷爾蒙」會槪於體二二 響生理痛之強弱,除了取決於這種荷爾釋放的多寡,有子宮壁層 : 宮内俯恤、紐⑽恤树靖#軸。若= 過於狹窄’細酿蝴__力也趣售树 重,也可能導致全身多處疼痛的原因。 s更嚴 經痛是婦科最常見病之_,可分絲發性和續發性4: 201221135 原發性經痛乡見於青春期未婚少女.,無明顯生殖器官病變,但月縣 攣性收縮疼痛,或因數宮頸狹窄'子宮後傾、經血逆流等成 體質有關。 、㈣。 續發性經痛起因於骨盆腔病變,易發生糾至计歲以上女性,或因子宮 肌瘤、子宮腺瘤、子宮嗔異做錄麵錢造成。 生理期失調長期疏於治療隱藏之慢性疾病: 生理期失調長期疏於洛療引發慢性疾病,如:月經時量多、質淡、血崩、 血漏、滴漏'出血、腫瘤、失眠等月經失調後遺症。201221135 VI. Description of the Invention: [Technical Field] The present invention provides a Chinese herbal medicine extracting and concentrating composition for treating female menstrual pain diseases, and using the Chinese herbal medicine extracting concentrated composition _ characteristics, rib treatment of female physiological period, towel, % Disordered & menstrual pain syndrome, including menstrual headache, dizziness, menstrual pain, severe pain or menstrual blood clots, small amount, amenorrhea and early menstruation, delayed, menstrual cold, mood disorders and prevention of uterine fibroids or ovarian chocolate cysts, tumor production Wait for 'female, health food or medicine for women's physiological period of menstrual pain syndrome. [Prior Art] Women's physiology before, during, and after dysregulation, causing menstrual pain syndrome and current treatment methods: Ancient medicine (four) syllabus syllabus is said to be rigorous, quite a lot of causes of menstrual pain including: no maturity or The diet is cold, and the external cause of six kinky (wind, heat, dampness, dryness, cold, fire) is retained in the body heat, inflammation causes menstrual pain syndrome, and now women are not like the ancient woman's physiology lying big, the second door is not _ scale _ Women in the county must not only receive formal education, but also have a place in the workplace. They must undertake academic or work pressures. 'There is a great replenishment of the physiological week, often unconsciously hurting your body; especially in physiology. In the mid-term, the damage caused by the unfair jewels is even greater. I got up in the morning, hurriedly sipped a cup of ice oxen _^ to work, the office touched the air: in order to lose weight, ate a lettuce-free salad with a cup of ice-free sugar-free drinks; after work, meet with friends to the fitness center swimming, SPA, If you just come across menstruation, there is a convenient tampon emergency, even if you swim in the water, you don't worry about escaping. If you go back to work, you have to work in the summer night, and you will be convinced that the uterus or the nest is angry. Dystagrant dysfunction dysfunction caused by dysmenorrhea, blood clots, irregular menstruation, low back pain, headache or mood disorders. Physiological hormonal imbalance dysmenorrhea syndrome: m has a unique body to listen to the chat, oysters to turn, secret hormone secretion 'body si for blood or other mixed side and money, from the physiological lining period, 201221135 female body In the period of the hormonal cerebral palsy, the center of these hearings is the pituitary gland, which is the lower part of the visual bed of the pituitary gland. It is the self-disciplined nerve. When the hormone changes, the autonomic nerve will be affected. Wrong IL; autonomic nerves are in charge of the nervous system controlled by human will, such as blood circulation, regulation of body temperature, operation of eunuch function, etc., and when this nervous system is inconsistent, it will cause headaches, dizziness, Symptoms such as vomiting, cold hands and feet, insomnia, and _ wilting are the biggest causes of various symptoms during the physiological period. Women will not only suffer from menstrual pain, but also the premenstrual syndrome. Premenstrual syndrome refers to all uncomfortable recordings of menstruation, including breast milk pain, emotional disappointment, lack of sexual spleen, edema, headache, back pain, abdominal pain, over-ordination or reduction of food and punishment, and even sleep disorders. Central Nervous System. Therefore, if the male partner next to the lady or the wife does not understand the physiological cycle of the girl lying on the moon, the money of the body and mind may be often blinded or inexplicably smashed because the woman’s menstruation is coming or being In the physiological cycle A. The cause of dysfunctional abdominal pain is the uterine contraction caused by hormones, which are exfoliated by the contraction of the uterus. The principle is similar to production - contracting the uterus, causing pain: and the physiological period will also cause the contraction of the uterus to produce phase _ pain, which will cause gastrointestinal contraction; After the female rides the body to the next period of the chest, the luteal phase, during the luteal phase, will increase rapidly and then rapidly decline. The central part of the hormone is located in the lower part of the bed, which is the same as the position of the autonomic nerve center; therefore, the change, the association of the autonomic nerve will be affected, and the physical and mental condition will also fall into a mess; the frequency hormone is thickened the endometrium. 'Controlling the peristalsis of the intestines causes abdominal filling, relatively, in the cause of = easy to sputum; this "uterine contraction hormone" that promotes uterine contractions will succumb to the strength of physical pain, except for this kind of hormone The amount of release, there are uterine wall layer: intrauterine tummy, New (10) shirt Shujing # axis. If = too narrow, 'fine brewing __ force is also interesting to sell trees, it may also cause multiple pains in the body. s more severe menstrual pain is the most common gynecological disease, can be divided into silk and recurrence 4: 201221135 primary menstrual pain in the adolescent unmarried girl., no obvious genital lesions, but the month of sexual contraction pain, or Factor cervical stenosis 'posterior tilt, menstrual blood reflux and other physical related. (4). Sustained menstrual pain is caused by pelvic cavity disease, which is easy to occur in women who are over the age of more than one year old, or caused by uterine fibroids, uterine adenomas, and uterus. The physiological period is long-term neglected to treat hidden chronic diseases: The physiological period is long-term neglected by Luo treatment, causing chronic diseases, such as: menstrual volume, light, blood collapse, blood leakage, drip leakage, bleeding, tumor, insomnia and other sequelae of menstrual disorders .

經痛不是只有雕魏料上料會翻生軸來而引發頭 痛甚至有些人會贿血。输球域舰絲吐缚_,嚴重的生職 期障礙,會頭痛得像要爆掉一樣,甚至會钔艮想從樓上跳下來,痛不欲生的 感覺,影響中樞神經系統甚深。 調查結果顯示生理疼痛的程度會比頭痛、胃痛更痛: 每3人有2人做軸賺,冑6成女健躲痛嚴錄響上課工作; 調查結果顯示,68%女性有經痛的困擾,嫩超越頭痛與佩胃痛,有57 %的女性最想把經痛趕出自己的人生,也有超過_的女性認為,經痛已 經嚴重影_她們的日f生活聽,包含上課或工作。 調查結果顯示女性經期時最常發生的症狀: 根據經痛大嫌數_示,高達78%的女財肚子__,51%的 女性在生理期間有情緒低潮«的現象。顯示女性在生理期時,心理也大受 影響’調查發現’女性經痛時心理常伴隨貞面情緒,分別有32%的女性在 經痛時的^聲是下輩子我要當$的,以及每次經_容脾氣罵人。 女性生理期經痛症候群依其病症程度分成四期: 第:期-般型_,人數比率佔鐵:臨床症狀―、有乳房脹痛、情緒不 穩定、脾氣顧缺乏耐性、冒冷汗、頭痛、目眩、想吐、手腳發冷、失眠、 201221135 雜寡歡 '勝廋背痛、腹痛、食慾過盛或減少,甚至睡眠障礙等症狀。臨床 症狀二、月經排經血量少、血塊、閉經、月經提前、延後等。 第二期非出血性肌瘤型經痛,人數比率佔15% :臨床症狀,除了有一般型 經痛所有症狀外,會有荷i蒙失娜響自律神經錯亂症候群產生。 肌瘤的產生是生理期間子宮内膜本該隨排經血剝落,反因為外因六淫(風、 暑、濕、燥、寒、火)滯留於女性腹腔與子宮内膜,造成排經血時剝落不全, 細疏於治療’最終戦子魏贼纟卩巢巧克力雜,驗者好宮肌瘤或 卵巢巧克力囊腫5公分町者’ ^要適當治療即可彳轉;竹肌瘤或卵巢巧 克力囊腫5公分社麵嚴重者,辦卩時以手術切除練,術後在適當以藥 物治療即可。 第三期出血性肌瘤型經痛,人數比率佔1〇% :臨床症狀,除了有前兩期經 痛所有症狀外’會有脸域、丨血、賴的跡。碱原目—為生理期間 子宮内勵_血剝落不全,形成子宮肌瘤或即巢巧克力囊腫壓迫造成出血性 經痛;形成原因多為_性遺傳,因長輩或母親多屬於原發性經痛,多見於 青春期未婚少女,無_生殖器官賴,來會有痙雜收縮疼痛,或因 子呂頸狹窄、子宮後傾、經血逆流等因素造成,與體質有關。 第四期腫瘤經痛’人數比轉5% :臨床症狀,除了有前三期經痛所有症狀 外’會有脑時量多、質淡' i崩、腫瘤、失祕的情形。形成朗為續發 性經痛起目於骨盆舶病H發生·紐歲社姐,或奸宮肌瘤、 子宮腺瘤、子宮簡異位錢骨盆腔感染造成。 傳統西方醫學治療女性經痛的方法: 目則全球對女性經獻能止痛’無治療方法,起因為目前全球西方醫學 無任何先進醫療設備或醫療人員,可以探測或診斷得知,女性生理期失調^ 係因外因六淫(風、暑、濕、燥、寒、火)雜於體内化熱、發炎因引起經 痛症候群,造成經痛原因,更不知如何怯除外因六淫(風、暑、濕、燥、寒、 火)滯留治療的方法;然而目前市面上與醫院較為廣泛使用的治療、止痛藥 201221135 為西藥普拿疼(Panadol)。 子宮肌瘤或印巢巧克力囊腫治療··西方醫學唯有手術切除、治療,術後治 療須注射含黃體素的停經針二個月以上,g己合消炎止痛藥_普拿疼(Panad〇丨) 的服用’會有身體虛弱無力、全身潮熱如更年期一般不適感。 西藥普拿疼(Panadol)的成份為:Acetaminophen ; Pseudoephedrine HC ; Chlorpheniramine maleate(因含有乙醯、苯紛,故傷肝),可為腸胃道 吸收迅速完全。0.5-2小時可達到最高血中濃度。服藥過量時,吸收在4小 時内完成。在尿中主要以glucuronate及sulfate結合物(94%)排出。約 4%經由cytochrome Ρ·450氧化酵素代謝為毒性物,肝功能必須正常狀況 下才會優先與glutathione結合並由尿液排出。 台灣長庚醫院内科黃嘉勳醫師淋傑梁教授;介紹普拿疼(panad〇|)中毒 (Acetaminophen intoxication): 長期或突然服用大量acetaminophen時,glutathione存量耗盡,毒性代謝 物可能造成肝臟壞死。Acetaminophen 24。/。以原型排出,半衰期為1_3小 時’新生兒及肝硬化者的半衰期稍長(2.2-5小時)。吃Panado丨只要二十六 顆’就會致命,因為會對肝臟及循環系統造成無法補救的傷害,因含有乙醯、 苯酴’故傷肝’據報八小時内向醫院求助治療,超過八小時即使治療也會造 成終生不孕症難以疾癒的傷害;通常第二天會開始覺得不舒服、噁心想吐; 第四天會陷於昏迷,第五天就有生命危險,所以藥還是不要亂吃的好。 普拿疼(Panadol)不含阿司匹林不傷胃,普拿疼雖不傷胃,但普拿疼的 副作用卻傷肝。小孩子吃過量可能會引起猛暴性肝炎,而有肝炎的病人更是 禁吃,尤其是B型肝炎者,會使GOp、gpt都升高很多,大多數的止痛藥 都會傷肝,西藥則幾乎都傷腎。 普遍傳統中醫治療方法: 201221135 中醫認為女性在月經前後’受病變因素影響,沖任胞宮氣血急驟變化, 運行不暢峨视_或失機柄榮_。臨肚虛實不同經痛 症:氣滯血齋、寒濕凝滞、氣血虛弱、肝腎虛弱。 隨傳統醫師辨證而以膈下逐齋湯、少腹逐齋湯、聖愈湯、調肝湯等論治 之’因病症不同服用時間長,如顧中藥四物湯組成的義就更為激烈,四 物湯適用於有貧血症狀的人’做為補血、補鐵f使用,騰有子宮肌瘤或印 巢巧克力囊腫患者飲用四物湯類藥品,將會舰瘤或囊腫加速成長更加惡 化’因而使用四物湯類藥品時前須先詢問醫師,檢視身體狀況後再服用。 針灸耳針方面可以取穴關元、中極、子宮、血海、内分泌、神門、肝點 等。理氣化齋改善子宮環境。或财藥熱敷包:艾葉、細辛、小菌香,三藥 熱炒裝袋Μ少腹’可溫下焦、去寒濕、止經痛,唯只能解表舒緩,無法清 除内在寒濕。 中藥保健藥膳,眾說紛紜僅食療活血化療、溫經止痛效果是有限的。 依據波仕特線上市調_5幽近日便勒亍一項網 路民調’如統計表1;統計表2 ;統計出女性經痛的比例,其中每次經期來 都會痛的占23%,經常痛的占30%,偶而才痛的占概完全沒有此困擾 的女性比例只有7%,可見這個問題對大多數的女性而言有一定程度的困擾。 統計表2 統計表1Menstrual pain is not only caused by the carving of the material, but it will cause headaches and even some people will bribe blood. Losing the ball in the field of warship _, serious life-stasis obstacles, will be like a headache to explode, and even want to jump from the upstairs, feeling unbearable, affecting the central nervous system is very deep. The results of the survey show that the degree of physical pain is more painful than headache and stomach pain: 2 people per 3 people do the axis earning, and 60% of the women are obsessed with the painful recording of the class work; the survey results show that 68% of women suffer from menstrual pain. Tenderness surpasses headache and stomach pain, 57% of women want to drive menstrual pain out of their own life, and there are more than _ women who believe that menstrual pain has been seriously _ their daily life, including class or work. The results of the survey show the most common symptoms of menstruation during menstruation: According to the number of menstrual pains, up to 78% of female wealth __, 51% of women have a low tide during the physiological period. It shows that when women are in the physiological period, their psychology is also greatly affected. 'The investigation found that women's menstrual pain is often accompanied by facial emotions. 32% of women in the menstrual pain are the next generation, I want to be $, and each time _ temper temper. Women's physiological menstrual pain syndrome is divided into four stages according to the degree of the disease: No.: general type _, the proportion of people accounted for iron: clinical symptoms -, breast pain, emotional instability, temper lack of tolerance, cold sweat, headache, dizziness , want to vomit, cold hands and feet, insomnia, 201221135 Miscellaneous sorrows, sputum, back pain, abdominal pain, excessive appetite or reduction, and even sleep disorders. Clinical symptoms 2, menstrual drainage, blood clots, amenorrhea, early menstruation, delay and so on. The second phase of non-hemorrhagic fibroids type of menstrual pain, the proportion of the proportion accounted for 15%: clinical symptoms, in addition to all the symptoms of general type of menstrual pain, there will be a loss of self-disciplined neurological disorder syndrome. The production of fibroids is that the endometrium should be exfoliated by blood during the physiological period, because the external cause of six kines (wind, heat, dampness, dryness, cold, fire) is retained in the female abdominal cavity and endometrium, causing exfoliation when draining blood. , subtle treatment of 'final scorpion Wei thief nest chocolate miscellaneous, the tester good uterine fibroids or ovarian chocolate cysts 5 cm towns' ^ to be appropriate treatment can be transferred; bamboo fibroids or ovarian chocolate cysts 5 cm If the social situation is serious, the surgery should be performed after surgery, and the drug should be treated properly after surgery. The third stage of hemorrhagic myoma is menstrual pain, the proportion of the number of people accounted for 1%: clinical symptoms, in addition to all the symptoms of the first two periods of menstrual pain, there will be traces of face, blood stasis, and reliance. Alkali original eye - for intrauterine stimulation during physiology _ blood exfoliation, the formation of uterine fibroids or nesting chocolate cyst compression caused by hemorrhagic menstrual pain; the formation of most causes _ sexual inheritance, because the elders or mothers are mostly primary menstrual pain, more Seen in adolescent unmarried girls, no _ reproductive organs, there will be noisy contraction pain, or factors such as narrow neck and neck, uterus backward, menstrual blood reflux and other factors, related to physical fitness. In the fourth stage, the number of patients with menstrual pain was 5%. The clinical symptoms, except for all the symptoms of the first three periods of menstrual pain, were more likely to have more brains, less dysfunction, tumors, and secrets. Forming a continuation of the continuation of menstrual pain caused by the occurrence of pelvic disease H, New Year's sister, or gangster fibroids, uterine adenoma, uterine simple ectopic money caused by pelvic infection. Traditional Western medicine for women's menstrual pain: The goal is to provide pain relief for women in the world. There is no treatment. Because there are no advanced medical equipment or medical personnel in the world's Western medicine, it can be detected or diagnosed, and women's physiological period is out of sync ^ Because of the external cause of six kinky (wind, heat, dampness, dryness, cold, fire) mixed with heat in the body, inflammation caused by menstrual pain syndrome, causing menstrual pain, but also do not know how to exclude the six kinky (wind, heat, wet, Dry, cold, fire) method of retention treatment; however, the currently widely used therapeutic and analgesic drugs 201221135 on the market and hospitals are Panadol. Treatment of uterine fibroids or printed chocolate cysts · Western medicine only surgical resection, treatment, postoperative treatment must be injected with lutein containing menopause needle for more than two months, g have anti-inflammatory painkillers _ Pu Nao pain (Panad〇丨) taking 'will have weak body, body heat, such as menopause, general discomfort. The ingredients of Panadol are: Acetaminophen; Pseudoephedrine HC; Chlorpheniramine maleate (which contains liver and benzene, so it hurts the liver), which can be absorbed quickly and completely in the gastrointestinal tract. The highest blood concentration can be achieved in 0.5-2 hours. When the drug is overdose, the absorption is completed within 4 hours. It is mainly excreted in the urine with glucuronate and sulfate conjugate (94%). About 4% is metabolized to toxic via cytochrome 450450 oxidase, and liver function must be combined with glutathione and excreted in the urine. Professor Chang Jiaxing, Professor of Internal Medicine, Chang Gung Memorial Hospital, Taiwan; Introduction to Acetaminophen intoxication: When acetaminophen is taken for a long time or suddenly, glutathione is depleted and toxic metabolites may cause liver necrosis. Acetaminophen 24. /. Excreted by the prototype, the half-life is 1_3 hours. The half-life of the newborn and cirrhosis is slightly longer (2.2-5 hours). Eating Panado丨 as long as twenty-six will be fatal, because it will cause irreparable damage to the liver and circulatory system. Because it contains acetaminophen and benzoquinone, it hurts to report to the hospital for treatment within eight hours, more than eight hours. Even treatment will cause life-long infertility to be difficult to heal; usually the next day will start feeling uncomfortable, nausea and vomiting; the fourth day will be in a coma, the fifth day is life-threatening, so the medicine should not eat Good. Panadol does not contain aspirin and does not harm the stomach. Although the pain of Pula does not hurt the stomach, the side effects of the pain of Pula hurt the liver. Excessive consumption of children may cause violent hepatitis, while patients with hepatitis are forbidden to eat, especially those with hepatitis B, which will increase GOp and gpt a lot. Most painkillers will hurt the liver, while western medicine will kill the liver. Almost all hurt the kidneys. Common traditional Chinese medicine treatment methods: 201221135 Chinese medicine believes that women are affected by the disease factors before and after menstruation, and they are rushing to change the blood of the palace, and the operation is not smooth or stunned. There are different symptoms of dysmenorrhea: qi stagnation, cold and dampness, qi and blood weakness, liver and kidney weakness. With the traditional doctors' syndrome differentiation, the treatment of 膈下逐斋汤, Shaofuzhui Zhaitang, Shengyutang, Tiaogantang, etc. is considered to be due to different conditions, such as the combination of Chinese medicine and Siwutang. Siwutang is suitable for people with symptoms of anemia. It is used as blood supplement and iron supplementation. Patients with uterine fibroids or nested chocolate cysts drink Siwutang medicine, which will accelerate the growth of the ship's tumor or cyst. Ask your doctor before using Siwutang. Check your health before taking it. Acupuncture and acupuncture can be used to take acupuncture points, Zhongji, uterus, blood sea, endocrine, Shenmen, liver points and so on. Improve Qi and improve the uterine environment. Or the drug hot pack: Ai Ye, Asarum, small fungus, three drugs, hot-fried bags, less abdomen, can warm the lower coke, go to the cold and dampness, stop bleeding, only relieve the table soothing, can not clear the inner cold dampness. Chinese medicine health medicated diet, there are many different opinions, only the therapeutic blood circulation chemotherapy, warming and pain relief effect is limited. According to the listing of the Boss line _5 sec, a network poll was recently arrested as shown in Statistical Table 1; Statistical Table 2; the proportion of female menstrual pain was counted, and 23% of each menstrual period would be painful, often 30% of the pain, and occasionally the proportion of women who have no such troubles is only 7%, which shows that this problem has a certain degree of trouble for most women. Statistics Table 2 Statistics Table 1

女性析 50.008 / 404)0¾ 功鄉Female Analysis 50.008 / 404)03⁄4 Gongxiang

• t25*MjR 835*44® _gl棚:如丨仙坡出糊上 201221135 依據波仕特線上市調網(http://www pr>lletq「.c〇tT|.tw)i斤日便進行一項網 路民調,如統計表3 ;在經痛時會採取什麼方法來減輕疼痛?最多可複選兩 項。其中答案包括喝飲品,例如:黑糖、桂圓茶、熱可哥等比例最高,占38%; 接著比例相差無幾的第二名是休息’甚麼事情都不做占37%;然後依序是吃 巧克力33%、喝溫開水26%、吃止痛劑20%、熱敷14%等等。可看出女性 多透過飲食的方式來舒緩疼痛,無有效的治療食品或藥品。• t25*MjR 835*44® _gl shed: If 丨仙坡出上上201221135 According to the Boss line listed network (http://www pr>lletq".c〇tT|.tw) An online poll, such as Statistical Table 3, what methods will be used to relieve pain during menstrual pain? You can check up to two. The answers include drinking drinks such as brown sugar, longan tea, and hot coke. 38%; then the second most similar proportion is rest 'do not do anything 37%; then in order to eat chocolate 33%, drink warm water 26%, eat analgesic 20%, hot compress 14%, etc. It can be seen that women use the diet to relieve pain and have no effective treatment for food or medicine.

統計表3Statistical Table 3

•mm •Ml 这職 〇B*峨 δ mm i aanng 1-¾¾ 综觀以上敘述,東、西方醉在治療女性生理期經痛症候群的醫療技術•mm •Ml This position 〇B*峨 δ mm i aanng 1-3⁄43⁄4 Looking at the above description, the medical technology of East and West drunk in treating women's physiological menstrual pain syndrome

是各有極需突破的需求;有鑑於此’實有必要開發利财草麟性,創造可 取代Panadd ’有效、快速止痛’無副作用’不須長期顧即可達到怯除外 因六淫(風、暑、濕、燥、寒、火)滯留的方法,治療女性生理期經痛症候 群問題,進而預防子宮肌瘤或印巢巧克力囊腫產生專用的食品、保健食品或 藥品。 【發明内容】 本發明提供—種治療女性_赫的切料取濃縮組合物,專用 於治療女性_症候群疾病,第―期―般型_、第二期非出血性肌 瘤型經痛、第三期心性肌瘤型經痛、“___等治療專用 201221135 的中草藥萃取濃齡合物之食^、保齡^或藥。$。 本發明之中醫辨證論治: 女性經痛疾病的病理機轉:本發明提供治療女性經痛疾病的中草藥萃取 濃縮組合物’配合病理機轉研發’目的在解決女性平常或生理期間,不正常 的生活習慣和冰雜食,以及愛美女性喜愛穿露肚服飾,引入外因六淫(風、 暑、濕、燥、寒、火)滞留於體内,導致脾胃之氣無法運化荷爾蒙失調,影 響子宮收縮與自律神經中樞受到干擾,導致引發女性婦科、子宮或卵巢氣滞 轉功能失調’進而引起經痛症候群疾病;如乳魏痛、麵、目眩”區 吐、^廋背痛、腹痛、冒冷汗、手腳發冷、食慾失常、月經提前、月經延後、 月級量少、錢、情緒障礙、_寡歡、脾氣騎、睡眠障礙、白帶、 子宮肌瘤、巧克力囊腫、子宮内膜異位、月經時量多、質淡、血崩、血漏、 滴漏、出血、顧、子宮腺瘤、祕等造成生活鮮 痛症候敎其病症程度又分成四期如: 心 第-期-般型軸,人數比率佔聰:臨床症狀有麟臟、麵、目眩、 區吐、路痠背痛、腹痛、冒冷汗、手腳發冷、食您失常、月經提前、月觀 後、月經量少、蝴、閉經、情緒障礙、镫鬱寡歡、脾氣顧、睡眠障礙、 白帶等症狀。 第二期非出血_顧經痛,人數比率佔15%:臨床症狀,除了有—般型 經痛所有症狀外,會有翻蒙失纖響自律神經錯亂雜群產生。 肌瘤的產生是生糊财宮嶋本該麵經血繼,反@為外因六淫(風、 暑、濕、燥、寒、火)滯留於女性腹腔與子宮内膜,造成排經血時剝落不全, 長期疏於鱗’最終形成子魏瘤.巢巧克力細,織者好宮肌瘤或 卵巢巧克力囊腫5公分町者,只要適當治療即可復原;子宮肌瘤或印巢巧 克力囊腫5公分以上者為嚴重者,需即時以手術切除治療,術後在適當以藥 物治療即可。 201221135 第三期出血_瘤型經痛,人數比率佔職:臨床症狀,除了有前兩期經 痛=有症狀外’會有驗血漏n麟的情形。碱賴—為生理期間 子宮内藤敎剝落不全,形成子宮肌瘤或·巧克力囊腫壓迫造成出血性 、:痛’形成原ϋ多為細^遺傳,因長輩或母親多屬於原發性經痛,多見於 月軸未婚少女,無明顯生瘦器官病變月經來會有痙擎性收縮疼痛,或因 子宮頸狹窄、子宮_ '驗逆鱗Μ造成,無質有關。 第四,月腫瘤&痛,人數比率伯5% :臨床症狀,除了有前三期經痛所有症狀 外’會有月赠量多、質淡、血崩、腫瘤、失眠等的情形。形成原因為續發 • 健痛起盆_賴1發生糾至顺壯女性,子宮肌瘤、 子呂腺瘤子呂内媒異位症或骨盆腔感染造成。 本發明藥理機轉: 本發明治療女性經齡觸萃取濃驗合物,配合雜君、臣、佐 '使 四大機轉運用原理分析如: 君藥-用藥原則:加強接除外邪,接除滞留於脾胃、子宮體内的外邪, 齡女性婦__失調、子宮或«氣滯血__,發血塊、 子宮内臈剝落不全肌瘤增生與月經症候群病症問題。 φ 個桂枝、陳皮、紫蘇、桔梗、遠志、防風—入氣分祛外邪;遠志寧神。 引用當歸、㈣、的、桃仁—人血分;桃仁核血。 臣藥-用藥原則:加強脾土之氣,清除外邪滯留化熱造成脾胃之氣無法 運化何爾蒙失調,影響子宮收縮與自律神經中樞受到賴造成失眠、雜寡 歡、情緒低潮麵與月經症候群病症等問題。 引用茯茶、厚樸、大腹皮、龍眼肉、白朮、烏藥、积殼、黃耆、大農 仁—加強脾土之氣;將脾之氣引入子宮或卵巢。 五靈脂、紅花、蒲黃'人參—加強藥物入血分及去齋血。 白笈-防止子宮或卵巢出血、血漏、滴漏。 佐藥—用藥原則··加強溫子宮、絲氣、活血化癖,幫助子宮化除錢 201221135 子宮内膜能完整繼’減__瘤歡齡,触婦科帶脈雜,解除月 經症候群病症問題。 、 引用桃仁、牡丹皮、赤苟、沒藥、虹—μ分,以活血化療,故能止痛; 沒藥去發血;牡丹皮’祛外邪滯留則化熱,用以清熱。 炙甘草、陳皮、料去除職滞麟造成_熱;炙甘草調和諸藥。 小菌香、乾薑、肉桂—溫脾胃、縣氣,之後舞胃之氣移給子宮用再a 子宮。 使藥-用藥原則:將活血化赖主藥由脾胃狀子宮加強祛除寒氣、 溫子宮,減除氣滯场造成痛經、血塊的月經症候群病症問題。 引用牛膝、延胡索、黃柏—引主藥入子宮輕巢;引入丹田;子宮屬丹田· 的一部分。 發明冶療女性經痛疾病的中草藥萃取濃縮組合物之第一組組合物 方,其配方組合物依病理與藥理機轉與安全劑量細使用原則配伍,專件 療女性賴疾病第,-般酿雜合物,射包妳請、桃仁、川号 延胡索、桂枝、牡丹皮、的、蒲黃、牛膝,、五靈脂、紅花、茯乂 〇腹皮、紅、魏、«、生M、_、沒藥、赌、自求、厚朴、灸.It is a demand that needs to be broken. In view of this, it is necessary to develop profit and wealth, and create a substitute for Panadd. 'Effective and rapid pain relief' without side effects can be achieved without long-term care. , heat, dampness, dryness, cold, fire) retention method, treatment of women's physiological period of menstrual pain syndrome, and then prevent uterine fibroids or printed chocolate cysts to produce special food, health food or medicine. SUMMARY OF THE INVENTION The present invention provides a concentrated composition for treating female _ 赫, specifically for treating female _ syndrome disease, the first period - general type _, the second stage non-hemorrhagic myoma type menstrual pain, the third Cardiac myoma-type menstrual pain, "___, etc. 201221135 Chinese herbal medicine extraction concentrate compound food ^, Bao Ling ^ or medicine. $. TCM syndrome differentiation treatment: pathological mechanism of female menstrual pain disease: the present invention provides The Chinese herbal medicine extract concentrate composition for treating women with menstrual pain disease is designed to solve the normal or physiological period of women, abnormal habits and ice omnivores, as well as the love of beauty, wearing a belly dress, introducing an external cause of six kinky (wind , heat, dampness, dryness, cold, fire) stay in the body, resulting in spleen and stomach can not transport hormone imbalance, affecting uterine contractions and autonomic nerve center interference, leading to gynecological, uterine or ovarian qi dysfunction dysfunction Inducing menstrual pain syndrome diseases; such as milk Wei, face, dizziness, vomiting, back pain, abdominal pain, cold sweat, cold hands and feet, loss of appetite, Advance, delayed menstruation, less monthly grade, money, mood disorder, _ 寡 欢, temper ride, sleep disorders, vaginal discharge, uterine fibroids, chocolate cysts, endometriosis, menstrual volume, light, blood collapse Blood leaks, dripping, bleeding, Gu, uterine adenoma, secrets, etc. cause life pain symptoms, and the degree of the disease is divided into four stages, such as: heart-phase-like type axis, the proportion of the proportion of Zong Cong: clinical symptoms have lining , face, dizziness, vomiting, acid back pain, abdominal pain, cold sweat, cold hands and feet, eating you abnormal, early menstruation, after the moon, less menstruation, butterfly, amenorrhea, mood disorder, depression, temper , sleep disorders, vaginal discharge and other symptoms. The second phase of non-bleeding _ Gu Jing pain, the proportion of the proportion accounted for 15%: clinical symptoms, in addition to all the symptoms of general-type menstrual pain, there will be a disorder of the loss of self-disciplined neurological disorder. The production of fibroids is the result of the sputum of the sputum of the sacred sacred sputum, and the anti- @ 为 为 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( Long-term neglected scales, the final formation of Ziwei tumor. Nested chocolate fine, woven uterus fibroids or ovarian chocolate cysts 5 cm, can be restored as long as appropriate treatment; uterine fibroids or printed chocolate cysts 5 cm or more for In severe cases, surgical resection should be performed immediately, and appropriate medication should be used after surgery. 201221135 The third stage of bleeding _ tumor type of menstrual pain, the proportion of the occupation: clinical symptoms, in addition to the first two periods of menstrual pain = symptoms, there will be blood test leakage. Alkali Lai - during the physiological period, the uterus in the uterus is sparse, and the formation of uterine fibroids or chocolate cysts is caused by hemorrhagic, and the pain of the formation of the original sputum is mostly fine, genetic, because the elders or mothers are mostly primary menstrual pain, more common in Unmarried adolescent girls on the moon axis, no obvious thin organ disease, menstrual cramps, or cervical stenosis, uterine _ 'test stenosis caused by spleen, no quality related. Fourth, monthly tumor & pain, the number of people 5%: clinical symptoms, in addition to all the symptoms of the first three menstrual pain, there will be more than a month of gift, light, blood collapse, tumor, insomnia and so on. The reason for the formation is the renewal. • The pain is caused by the sputum. The pharmacological machine of the invention turns: the invention treats the female age-extracting extract concentrated complex, and cooperates with the miscellaneous Jun, Chen, Zuo's to analyze the principle of the four major machines for transporting, such as: Jun medicine - medication principle: strengthen the exclusion of evil, remove Exogenous stagnation in the spleen and stomach, uterus, age women __ disorders, uterus or «qi stagnation __, blood clots, uterine insufficiency incomplete fibroids hyperplasia and menstrual syndrome problems. φ Guizhi, Chenpi, Perilla, Campanulaceae, Polygala, and wind-invasion--------- Citing Angelica, (four), the peach kernel - human blood; peach kernel blood. The principle of drug-drug: strengthen the spleen and gas, remove the heat of spleen and stomach, and the spleen and stomach can not transport the hormonal imbalance, affecting the uterine contraction and the autonomic nerve center, causing insomnia, miscellaneous, emotional low tide surface and menstruation Problems such as syndromes. Cigarette tea, magnolia, large belly skin, longan meat, atractylodes, black medicinal herbs, shells, scutellaria, large peasants - strengthen the spleen gas; introduce spleen gas into the uterus or ovaries. Wulingzhi, safflower, Puhuang 'ginseng' - strengthen the drug into the blood and go to the blood. White sputum - prevent bleeding from the uterus or ovaries, blood leaks, and dripping. Adjuvant-medicine principle··Strengthen warm uterus, silk qi, promote blood circulation and remove blood stasis, help uterine change and remove money 201221135 Endometrium can be completed in succession __ tumor age, gynecological family with pulse, relieve menstrual syndrome symptoms. Reference to peach kernel, peony bark, red peony, myrrh, rainbow-μ, to promote blood circulation chemotherapy, so it can relieve pain; no medicine to blood; peony skin 祛 祛 邪 邪 则 则 化 化 化 化 化 化 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞 滞炙 草 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 Small bacteria, dried ginger, cinnamon - warm spleen and stomach, county gas, after the dance of the gas to the uterus with a uterus. The principle of drug-medication: the main medicine for promoting blood circulation to the spleen and stomach is to strengthen the spleen and stomach, remove the cold, warm the uterus, and reduce the qi stagnation field to cause menstrual syndrome symptoms of dysmenorrhea and blood clots. Reference to Achyranthes, Corydalis, Phellodendron - lead the main medicine into the uterus light nest; introduce Dantian; the uterus is part of Dantian. The invention relates to a first group composition of a Chinese herbal medicine extracting concentrated composition for treating women's menstrual pain diseases, and the formula composition is compatible with the pathological and pharmacological machine and the safe dosage fine use principle, and the special treatment for women's disease is the first. Compound, injection bag, peach kernel, Chuanzhihu, cassia twig, peony bark, puhuang, achyranthes, five spirits, safflower, scorpion skin, red, Wei, «, raw M, _, myrrh, gambling, self-seeking, magnolia, moxibustion.

草等組成;專供治療第,—般型_、佔軸人數比率7卿的 取濃縮配方組合物; 、 本發療姐經触病的巾草鮮取濃驗合物^恤合如 ^其配方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,柄 療女性經痛疾病第二賴血性肌瘤型經痛組合物,其中包含有:當㈣ :、=、延胡索、桂枝、牡丹皮、的、蒲黃、牛膝、柄、五靈脂] :朴=腹皮、生甚、肉桂、沒藥、桔梗、白求 期非_、_、侧、缕錄、询㈣;_療第: =血_舰_、觸Λ_ 15撕術咖配方㈣ 12 201221135 本發明治敍舰航病齡草鮮取濃·合物m组合物配 方’其配方組合物依病理與藥理機轉與安全缝範圍使用原則配伍,專供治 療女性域疾絲三期·性肌触經雜合物,糾包含有:當歸、川寫、 白苟、黃^人參、龍眼肉、酸棗仁、遠志、茯荟、白求、熟地黃、生地黃、 槐子、生薑、_炙甘草、黃連、黃柏、大棗、白复等組成;專供治療第三期出 灰細齡紅痛、佔經痛人數比率1〇%的中草藥萃取濃縮配方組合物;Composition of grass, etc.; for the treatment of the first, the general type _, the proportion of the number of people occupying the core of 7 Qing's concentrated formula composition;, the hair treatment of the sister of the sickness of the grass to take a strong test compound ^ ^ ^ The formula composition is compatible with the pathological and pharmacological machine and the safe dosage range, and the stalk treatment of the female menstrual pain disease second blood-type fibroid type menstrual pain composition, which includes: when (four):, =, yanhusuo, cassia twig, peony bark ,, Puhuang, Achyranthes, Stalk, Wulingzhi]: Park = belly skin, raw, cinnamon, myrrh, platycodon, white stagnation, _, _, side, sputum, inquiry (four); : =血_舰_,Touching _ 15 tearing coffee formula (four) 12 201221135 The invention of the invention of the ship of the ship of the age of the grass fresh concentrated complex composition formula 'the composition of the composition according to pathology and pharmacological machine transfer and safety seam The scope of use of the principle of compatibility, specifically for the treatment of female domain disease, the third phase of the myenteric contact mixture, including: Angelica, Chuan writing, white peony, yellow ginseng, longan meat, sour jujube, Yuanzhi, 茯, Baiqiu, Rehmannia glutinosa, Radix Rehmanniae, Radix Scutellariae, Ginger, Radix Glycyrrhizae, Rhizoma Coptidis, Phellodendron, Jujube, Baifu, etc. Fine ash treatment third instar red pain, menstrual pain representing the number ratio of the herbal extract 1〇% concentrate formulation of the composition;

本發明雜女性_疾栽巾轉萃取濃驗合物之細組組合物配 方’其配方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍專供治 療女性經痛疾病第四期腫瘤懿痛組合物,其巾包含有:當歸、延胡索、桂 枝、牡丹皮、的、蒲黃、略桃仁、牛膝、柄'五靈脂'人參、肉桂、 沒釤滅、紅,、白[紫蘇、厚朴、甘草'樓鄉、黃考'防風、木香、 烏藥木、4乾薑、小适香等組成;專供治療細期腫瘤麵痛、佔經痛人 數比率5%的巾草鮮取濃縮配方組合物。 本發明組合物藥理基源: 本發明治療女性經痛疾病的中草藥萃取濃縮組合物,中醫用藥配伍用量 依據與現代藥理學研究依據參考: 當歸,為繳形科植物當歸(Ange|jca 3_細(〇匕丨乂日叩旧LS)之乾燥 根,味甘;性平。歸經:肝;腎;肺經。功能:補姊血,能促進血液循環,、 調經止痛^_滑腸。主治:舰不調,賴賴,癥瘕結聚,崩漏,血虛 疼痛二軍;腸燥便難味趙重,癰疸瘡癌,跌撲損傷,宜用當歸尾。内 服·烈湯’ 6〜I2g。 1、 ·當歸主縣^含_&,苯_碳_杨_咖e_〇_carb_c acid) ’ Λ2,小一氫太酐(Δ2,小Djhydr〇帅a丨丨。吻她)。 2、 當歸現代藥理學研究依據: :麵彻_,#肖細餅宮平滑肌成 刀”,揮/,興奮成分為水溶性或醇溶性而乙醚不溶性的非揮發性物質。並 13 201221135 對杬垂體彳4葉素、靖、腎上腺纽乙麵轉彡丨細子宮條。當歸浸膏 主要為興奮,大繼树i抑制作用。 (2) 對在體子s的_ ••當歸細、輔、石細驗、水浸液等各種製劑 對麻醉狗、!肖、兔等動物的未孕、早孕、晚孕和產後各種在體子宮當歸揮發 油具有抑制在體子宮肌的作用。 (3) 抗錢作用:當歸及其阿魏軸有明顯的抗錢作用。大鼠實驗當歸可 使全幹;t#麟齡,姆增長速雜舰組下降。 (4) 抗腫瘤作用··各多雛品對大鼠移植性腫瘤Ec、H印、別8〇、l_s、 B16等瘤株具有一疋程度的抑制侧,其腫齡長抑制率可達,副作 用較少,且可長期用藥。 川考’為缴形科植物与藭(|JgustjCum chuanxj〇ng H〇rt 丨-議 auctnon Franch·】)之乾燥根莖。味辛;性溫。歸經:肝、膽、心包經。功能: 活血祕;行氣開鬱;接風止釤主治:月經不調;經職經;產後癖滯腿 痛’癥瘕腫塊;胸脅疼痛;頭痛眩暈;風寒濕癖;跌打損傷;癌症瘡瘍。内 服:煎湯’ 3〜1〇g。 1、 川寫主要成分:本品含蒿本内醋(LigusWide),丁基苯太(Buty_a|㈣, 丁基稀苯太(Butylidenphthalide)等精油。 2、 川芎現代藥理學研究依據: (1)對血小板聚集:蛛形成和血液枯滯度的影響川寫嗓延長在體外娜 誘導的血小板凝科間,對已聚集的血小板有·_。响嗪影響血小板 功能及蛛戦可能是频_ 之_物,撕制_ 的合成,發現在富含血小板血聚中,加入川.鎌τχΑ2弓!起的叙小板聚 受到顯著抑制。 集 (2)對平滑肌的作用:川芎浸膏的1〇%水溶液對姓娠家兔離體子宮,微量時 能刺激受孕子宮’使其張力增高’收縮增強,終成攣縮;大量則反使子宮麻 痹而收縮停止。川辕膏小魏抑讎體家兔或贱小腸,大量則可使小腸 201221135 收縮完全停止。 ()對外周血^與血壓的伽:川琴總生物齡^丨丨琴嗪能賴都犬血管阻力 下降’使腦、股動觀下肢血流量增加。川号生物驗、盼性部分和川寫嘻能 抑制氯化鉀與腎上腺素對家兔離體胸主動脈條的收縮作用。川写浸膏、水浸 液乙醇水浸液、乙醇浸出液和生物驗對犬、系苗、兔等麻醉動物,不論丨⑺ 或iv均有顯著而持久的降壓作用。 白芍,為毛茛科植物芍藥(pae〇nja lactjfl〇ra pALL=p a丨P·) 除去栓皮之乾燥根。苦;酸;微寒。歸經:肝;脾經。功能:養姆^營藥; 緩急止痛藥;斂陰平肝藥。主治:月經不調;經行腹痛;崩漏;自汗;盜汗; 脅肋脘腹疼痛;四肢攣痛;頭痛。内服 '煎湯,5〜12g。 1、 白芍主要成分:本品含麥胚固醇(P-Sit〇ster〇丨),芍藥甘(pae〇nifl〇ri⑴肌 醇(myoinositol),氧化芍藥甘(〇xypae〇nifl〇rin),苯曱基与藥甘,苟藥酮 (Paeoniflongenone)等。本屬植物根含沒食子單寧(Ga丨丨。 2、 白芍現代藥理學研究依據: ()解痙作用.&藥或$藥#對平滑肌有抑制或解瘦作帛,能抑制豚鼠離體 小腸的自發隨縮,使其張力降低,並麟抗氣化細起的豚鼠和兔離體小腸 的收縮,對乙纖驗所致離_、腸收縮無明顯影響但加用甘草後有顯著抑制 作用。 (2) 保神轉作用:的提取物對〇_半乳糖胺和黃纖毒素出所致大鼠 肝損傷與ALT升高,職麵致乳魏氫酶(SLDH)及其肛咖總活性升 高’均有_抑制作用^的乙醇提取液在體外對黃麴徽毒索m有一定降解 作用。對小鼠T-2毒素中毒有明顯解毒作用。 (3) 抗誘變輸腫瘤作用:的提取物能干擾S9混合液的酶活性,並能使 苯並汪(BAP)的代謝物失活而抑制BAp的誘變作用。沒食子酸(ga)和 五沒食子麟_萄糖(pGG)能使BAp的代驗纽,pGG能抑制S9混 合液的酶活性。的躲物能增麟、纖素C的碰瘤作用。 15 201221135 赤苟;為毛茛科植物川赤苟(paeonja vejtchii LYNCH)及同屬近緣植 物之乾燥根°苦;微寒;歸經:肝;脾經0功能:浙火,活血通經,消腫 止痛。主治:瘀滯經閉’血崩帶下,血痢腹痛,癍腫目赤,姆血。内服:煎 湯’ 4〜1〇g。 1、 赤芍主要成分:含麥胚固醇(P_Sit〇ster〇|),芍藥(Pae〇njfl〇rin),肌醇 (myoinositol),氧化苟藥(〇xypae〇njfl〇rjn),苯甲基芍藥,芍藥酮 (Paeoniflorigenone)等。本屬植物根含沒食子單寧(Ga丨丨〇tannin)。 2、 赤芍現代藥理學研究依據: (1) 抗血检形成作用:赤与煎劑15_2〇g(生藥ykg給大鼠灌胃,使血检形成時 間明顯延長’長度縮短,重量減輕;凝金酶原時間和白陶土部分凝血活酶時 間延長,優球蛋白溶解時間縮短,對血凝有顯著抑制作用。 (2) 抗血小板聚集作用··赤苟提取物在體外對腎上腺素、二^酸腺苦(ADp)、 賴頭蛇毒(TMVA)和花生四烯酸(Μ)誘導血小板聚集均有顯著抑制作 用’並使血小板枯附與血小板第三因數活性降低,血小板内含量升高。 ⑶保肝作用·赤芍注射液對體外培養肝細胞的DNA合成有明顯促進作用, 對肝細胞再生和肝功能恢復有良好影響。對D_半乳糖胺所致大鼠肝損傷有 明顯保護作用。 甘草;豆科植物甘草(Glycyrrhiza uralensis FISCH.)及同屬近緣植物之 乾燥根及地下根狀莖。味甘,平。歸經:入脾、胃經。功能:補脾益氣,調 和藥性,清熱解毒,緩急止痛,潤肺止咳。主治:脾胃虛弱,腹痛便溏,調 和諸藥。治癰疸瘡瘍,咽喉腫痛,肺漆咳嗽,心悸驚癇。内服:煎湯,18 〜12g。 1'甘草主要成分:本品含烏熱酸(Uralenic acid),甘草酸(Glycyrrhizic acid), 甘草酮(Licoricone)等。粉甘草含異甘草(|S0|jqUjritjn),新甘草 (Neoisoliquiritin),甘草環氧酸(Liquoric acid),甘草甜素(Glycyrrhizin),美 草醇(Glycyrrhetol) ’ 鼠李糖甘草(Rhamnoliquiritin),甘草二酸(Liquiritic 16 201221135 acid) ’ 刺芒柄花素(F〇rm〇n〇netjc),甘草次酸(18_p_G丨ycyrrhetjnicacj⑴甘 草雙酮(Glabrene)等。 2、甘草現代藥理學研究依據: (1) 對月腸平滑肌的解痙作用:使用甘草所含黃酮甙類對兔、豚鼠的離體腸 管呈抑制作用,使收縮次數減少,緊張度降低。甘草煎液、甘草流浸膏、 FmlOO、甘轉、異甘草料,觸管有鴨祕痙作用。 (2) 鎮靜作用:甘草次酸125〇mg/kg,對小鼠恤神經系統呈現抑制作用, 可引起鎮靜’催眠,體溫降低和呼吸抑制等。 ⑶抗腫瘤侧··甘雜對錢腹撕叙诚狀腹核(EAC)細胞能 產生形態學上的變化,還能抑制皮下移植的吉田肉瘤,其單錢鹽對小鼠艾氏 腹水癌及肉瘤均有抑制作用,口服也有效。 桂枝’為樟科植物肉桂(Cinnamomum cassia BLUME)及其同屬類緣植 物之嫩枝。辛;甘;歸經:性溫’膀胱;心;肺經。功能··溫經狐,發汗 解肌。主治:風寒表證,傷風頭痛’中風自汗,手足痛風捣風,經閉癥瘕。 内服:煎湯6〜15g,大劑量,可用至15〜3〇g。 1、 桂枝主要成分:桂枝含揮發油069% ,油中主要成分為桂皮醛 (dnnamaldehyde) 64.75。/〇 ’ 還有苯甲酸苄酯(benzylbenzoate),乙酸肉 桂酿(cinnamyiacetate),p-蓽澄茄烯((^cadinene),菖莆烯(ca丨amenene), 香豆精(coumarin)等。 2、 桂枝現代藥理學研究依據·· ⑴解熱作用:桂皮醛(cinnama丨dehyde)能使皮膚血管擴張,有解熱作用 (2)鎮痙作用:有抑制中極神經作用。 ⑶對於消化系統之影響:對大白鼠拘束水浸胃引發潰癌有抑制作用,促進 膽汁分泌。 (4)抗菌作用:對病原性絲狀菌有抑制作用。 肉桂’為樟科植物肉桂(Cinnatnonnum cassia LIUME)之乾燥樹皮。辛; 201221135 甘;熱。歸經:腎;脾;心;肝經。功能:補命門相火,溫腎壯陽,補虛勞, 破療血’通利經閉。主治:沈寒痼冷,虛寒腹痛,泄渴,寒痴奔脉,腰膝冷 痛’風痒骨節攣縮,產後腹中瘕痛。内服:煎湯,2〜5g。 1、 肉桂主要成分:含桂皮烯寧(Cinnzey|anjn),桂皮烯酮(Cinnzey丨an〇丨),肉 桂帖八(〇丨旧0358丨0丨八),肉桂八葡萄甘(〇丨11110388丨0|八911]00細6),肉桂帖 C1、肉桂帖B、肉桂帖B葡萄甘、肉桂帖D1、肉桂帖D1、葡萄甘,肉桂 帖D2、D3、C2、C3,肉桂帖D2葡萄甘,肉桂帖C1葡萄甘。本屬樹皮含 桂皮酸{Cinnamaldehyde)。 2、 肉桂現代藥理學研究依據: ⑴健胃和驅風劑:内服可作健胃和驅風劑。也有明顯的殺真菌作用,曾應 用含1.5%桂皮油及0.5%麝香草酚的混合物治療頭癬。桂皮醛及肉桂酸納可 引起娃足蹼膜血管擴張及家兔白細胞增加。 (2) 腸管興奮作用:桂皮油給家兔口服,能促進腸運動,使腸管興奮。對離 體家兔腸管具有嘯侧’為古人暖脾胃,齡狀難了贿的解釋。 (3) 通經作用.大罝桂皮油可引起子宮充血,顯示通經作用,此為古本草說 的墜胎作用提供了一個實驗依據 (4) 對血液的作:肉桂有_抑制ADp誘導的大鼠血小板聚集的作用,體 外試驗顯示肉桂水煎劑及溶甲醇部分有較強的抗凝作用。 (5) 鎮靜作帛:肉桂中含有的桂皮麟小鼠有明顯的鎮靜作用,表現為自發 活動減少’對抗甲基苯丙胺(Metha_etamine)所產生的過多活動,小 鼠壓尾刺激或腹腔注射醋酸觀察扭體運動的方法證明它有鎮痛作用。 桃仁’·為薔薇科植物桃(Prunuspersica^BATSCH)及is]屬近線植物之 乾燥成熟、去内果皮種仁。苦甘;平;無毒;歸經:心;肝;大腸;肺;脾 經。功能:破血行齋,潤燥滑腸。主治:經閉;癥瘕;熱病蓄血;風癖;癌 疾;跌打損傷;瘀血腫痛;血燥便秘。内服:煎湯,5 6〜12g。 1、桃仁主要成分:含脂肪’動力精__樣物質,赤黴素(Gjbbe「e丨丨jn)A32, 201221135 甲烯環木波蘿醇(24-Methylenecydoartanol),檸檬二烯醇(citr〇stadienol), 麥胚固醇(P~Sitosterol),苦杏仁甘(Amygdalin)等。 2、桃仁現代藥理學研究依據: ⑴祛齋血作用:水煎醇沉液可使離體兔耳靜脈血管流量增加,有舒張血管 作用。給麻醉犬動脈注射’能增加股動脈血流量及降低血管阻力,對血管壁 有直接擴張作用。有抑制血液凝固和溶灰作用。桃仁提取物5〇mg/m卜脾動 脈内給藥可使麻醉大鼠肝臟微循環内血流加速,對肝臟表面微循環有一定的 改善作用。 (2)抗過敏作用.桃仁水提物能抑制小鼠血清中的皮膚過敏抗體及雜鼠脾溶 血性細胞的產生,其乙醇提取物口服能抑制小鼠含有皮膚過敏性抗體的抗也 清引起的PCA反應(被動皮膚過敏反應)的色素滲出量。 延胡索’為罌粟科植物延胡索(C〇ryda|jSyanhUSU〇WUANG)及 同屬近緣植物之乾燥塊莖。苦甘;平;無毒。歸經:肝;胃;心;肺;脾經。 功能.活血散齋’利氣止痛’行血利氣要藥。主治:胸腹諸痛,月經不調, 崩中淋露,產後惡血凝滯,癒瘕撲損。内服:煎湯,5 6〜12g。 1、 延胡索主要成分:迷延胡索含紫堇莖驗(Covb—ne),紫堇鹼 (Corydaline) ’ 四氫棕橺鹼(Tetra_〇pa丨_ne) ’ 卡文驗(Cavidjne),等生 物驗。東北延胡索含紫堇莖驗,紫堇驗,四氫棕雛,原稿片劍Pr〇t〇pjne), 氫化小蘗驗(Canadine)。 2、 延胡索現代藥理學研究依據: ⑴鎮痛個:用電刺激小鼠尾巴法證明,延胡索粉、延織f素均有顯著 的鎮痛作用。 ⑺對肌肉的ϋ弛作用:漠化甲基延胡索乙素、四氫巴馬;讀兔、離體脉鼠 的實驗表明,對其肌肉有鬆弛作用。 ()對e系統的办響·延胡索麟物有顯著擴張離體兔心和在體描心的 %狀血管、降低冠脈阻力與增加血流量的_。對麻醉犬冠狀動脈的擴張作 201221135 用最明顯’頸内動脈次之。對股動脈也有一定的擴張作用。 牡丹皮’為毛茸茛科植物牡丹(p〇〇aeonja suffrutjcosa andr_)及同屬近 緣植物縱切剝除木部之乾燥根皮。辛苦;涼;微寒。歸經:心;肝;腎;肺 經。功能:清熱濕肝火’涼血,和血,消療。主治:傷寒熱毒發斑,站企, 吐血,便血’經閉’骨蒸勞熱’癰腫,金瘡内瘡。内服:煎湯,6〜9g。 1、 牡丹皮主要成分:本品含牡丹齡(paeon〇l),苯甲酸芍藥甘(Benz〇yl Paeorii florin)。 2、 牡丹皮現代藥理學研究依據: ⑴對心血管的影響:牡丹皮對麻醉犬心能增加冠脱A流量,減少心輸出量, 降低左室作功的作用。對實驗性心肌缺血有明顯保護作用,並且持續時間較 長,同時降低心肌耗氧量。用牡丹酚〇.5_1Og/kg給腎型高血壓犬和大鼠也 出現一定的降;1效果。 (2)抗凝作用:體外對人血小板織’發現牡丹皮水提物及苟藥紛均能抑制 血小板花生四烯酸產生蛛素A2,進而抑制血小板聚集,這是由於抑制從 铯生烯酸至前列腺H2的環氧化酶反應的結果。牡丹皮甲醇提取物有抑制内 毒素所致實驗性血栓的作用。 牛膝;為莧科植物懷牛膝(Achyranthes bidentata BLUME)及同屬近緣 植物之乾燥根。亦名白芍(《藥品化義》)。味苦、酸,性平。入肝;腎經。 力月散齋血/肖腫痛,補肝腎,強筋骨。主治:血齋戶斤致之痛經,經閉, 癥瘕,及產触衣不下’腹痛,及喉痒痛腫,跌打損傷,腰膝骨痛,四肢拘 攣疼痒。内服:煎湯,5〜构。 1、 牛膝主要成分:含稅皮固酮(Ecdysterone),牛膝固醇(|n〇k〇sterone)等。 2、 牛膝現代藥理學研究依據: (1) 對心臟的影響:牛膝醇提取液對離體娃心,麻醉貓有一定的抑制作用, 水別、劑對麻醉犬心肌的作用更為明顯。 (2) 對動物堅的影響:牛膝煎劑對麻醉貓和犬等均有短暫的降壓作用血 201221135 壓下降時伴有呼雌奮,雜個絲快速耐受現象,_其侧機制可能 與組胺的釋放、心臟抑制及擴張外周金管有關。 紅花;為菊科植物紅花(CarthamustinctoriusUNN)之乾燥花瓣。味辛; 性溫。歸經:入心,·脾;胃經。功能:活血能經;祕止痛。主治:經閉; 痛經’產後雜腹痛;胞痹心痛癥瘕積聚;跌打損傷獨疼痛;中風偏竣; 斑療。内服:煎湯’ 3〜1〇g。 ί匕主要成刀·含紅t (Carthamin),新紅花(Neocarthamine)(1),山 奈酚鼠李(Kaempferol3-rhamnoglucoside)等。 2、紅花現代藥理學研究依據: ⑴抑制心臟作:紅花煎劑小劑量能使蟾蜍離體心臟及兔在體心臟輕度興 奮’使心跳有力’振幅加大;大劑量則對心臟有抑制作用,使心率減慢,心 肌收縮力減弱,心搏出量減少。 (2)紅:?匕兴色素的抗凝血作帛:紅花黃色素具有非常顯著物制ADp誘導的 豕兔血小板聚集作用’並對ADp已聚集的血小板也有明顯的解聚作用。 ()降壓作用.紅花別劑、紅花黃色素對麻醉猫献有不同程度的迅速降壓 作用,平均血壓下降2〇分鐘Hg左右,持續約3〇分鐘後恢復。 ⑷對子宮的作用:紅花煎劑對小鼠、脉鼠、兔與犬的離體子宮有興奮作用。 制、鼠、酿烟麵子宮祕興奮作用。 五靈脂,為脊椎動物鼯鼠科橙足鼯鼠(trogoptems xanthipes MILNS-EDWARDS)之魏糞便。味苦;甘;性溫;歸^肝;脾經。功 此.行血止痛。主治:心腹金氣諸病,婦女經閉,產後齋血作痛,蟲咬傷。 内服:煎湯,5〜1〇g。 1、五靈脂主要成分:複齒錄鼠的乾燥糞便,含焦性兒茶紛(pyr〇catech〇丨), 苯甲酸(benZQicadd),3,-9,1()_二_ (3_caren-9 ,10-dicarb〇xylic acid)尿愈殿(urcj|),五靈脂酸⑽丨jn_cadd)間經基苯甲酸 (m hydroxybenzoicadd) ’ 原兒茶酸(protocatechujcadd),次黃嘌吟 201221135 (hypoxanthing) ’ 尿囊素(a||ant〇in)。 2、五靈脂現代藥理學研究依據: ⑴對心血管系統的影響:五靈脂2〇mg/kg股動脈注入使麻醉狗股動脈血流 量增加,血管阻力降低。五靈脂水提液200ug/ml可顯著降低大鼠乳鼠體外 培養心肌細胞的耗氧量。 (2) •抗凝作用:五靈脂水提液2 〇g/m丨有增強體外纖維蛋白溶解作用。 (3) .對子宮的作用:五靈脂水煎劑對離體家兔子宮呈短時間張力提高,幾分 鐘後恢復正常,部分出現後抑制現象,而對頻率、幅度影響小。體外試驗證 明,五靈脂對結核桿菌及多種皮膚真菌有不同程度的抑制作用;還有緩解平 · 滑肌痙攣的作用,臨床上也曾用於心絞痛。 蒲黃;為香蒲科植物香蒲(TyphaangustifoliaLINN.)及同屬近緣植物 之乾燥花粉。味甘、微辛;性平。躲:^ ;肝;雜。辦H用行齋利 尿’炒炭用收墙止血。主治:生用-治經閉腹痛,產後癖阻作痛,血淋,小 便不利’跌打損傷’癍腫。炒用_治崩漏’帶下,出金症:外治創傷,渔療。 内服:煎湯,5〜10g。 1蒲K主要成分.寬葉香蒲含葡萄糖,鼠李糖(Rhamn〇se),木糖 及其他低聚糖(Oligosaccharide)。 2、蒲黃現代藥理學研究依據: % (1) 對子宮及腸道平滑肌的作用:50%蒲黃注射液對豚鼠離體子宮和家兔在 體子宮均有興奮個。小継使酬竹錄猶增強,域量時子宮興奮 作用明顯職’呈不規則和痙攣性收縮。其機制可能與直接增加子宮收縮和 止血作用有關。蒲黃所含異鼠李素對小鼠離體腸管有解痙作用。 (2) 對心血管系統的影響:蒲黃提取液對離體兔心有明顯增加冠脈流量的作 用。對小鼠心肌微循環也有改善作用。 ⑶對凝血過程的影響:蒲黃能使家兔血,】、板數目增加,凝血酶元時間縮短, 有明顯縮短血液凝固時間的作用。蒲黃熟用炒炭,可增加止血作用。蒲黃中 22 201221135 的黃峨化合物(蘆丁、槲皮素等)具有止血作用的鞣f。 沒藥;為撖欖科植物沒藥樹(commiphora 輯脂。苦;平。歸經:肝;脾;心;腎經。功能:散血去二 痛。主冶· _,麵,Μ、遞勝齡_ 目障。内服1湯,3〜10g。 制The invention relates to a formula of a fine composition of a female _ 栽 巾 转 萃取 萃取 浓 浓 浓 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其 其The composition, the towel comprises: angelica, yanhusuo, cassia twig, peony bark, pudding, slightly peach kernel, achyranthes, stalk 'wulingzhi' ginseng, cinnamon, no annihilation, red, white [perilla, Houpu, licorice 'lou, township, Huangkao' windproof, woody, black medicinal wood, 4 dry ginger, small fragrant incense, etc.; for the treatment of fine-stage tumor pain, 5% of the number of menstrual pain The formulated composition is concentrated. The pharmacological base of the composition of the present invention: The Chinese herbal medicine extract concentrated composition for treating female menstrual pain disease according to the present invention, the compatibility of Chinese medical medicine according to the basis of modern pharmacological research reference: Angelica, for the family of Angelica sinensis (Ange|jca 3_fine (干燥日叩 Old LS) dry root, sweet; flat. Return: liver; kidney; lung. Function: make blood, can promote blood circulation, regulate menstruation and pain relief ^ _ sinus. Indications: Ships are not adjusted, Lai Lai, syndromes are clustered, uterine bleeding, blood deficiency and pain in the second army; intestinal dryness is difficult to taste Zhao Zhong, hemorrhoids cancer, fall damage, should use Angelica tail. Oral · Lie Tang '6~I2g 1. Danggui County County contains _&, benzene_carbon_yang_cafe e_〇_carb_c acid) ' Λ2, small one hydrogen hydride (Δ2, small Djhydr〇 handsome a丨丨. kiss her). 2, the basis of modern pharmacology research of Angelica:: face _, #肖细饼宫 smooth muscle into a knife", swing /, excited components are water-soluble or alcohol-soluble and ether-insoluble non-volatile substances. And 13 201221135 on the pituitary彳4 leaf 素, 靖, adrenal gland, 彡丨 彡丨 彡丨 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。. Various preparations such as fine test and water infusion have the effect of inhibiting the body uterus muscle in the non-pregnant, early pregnancy, late pregnancy and postpartum animals of anesthetized dogs, Xiao, rabbits, etc. (3) Anti-money effect : Angelica and its ferulic axis have obvious anti-money effect. Rats in the experimental experiment can make the whole dry; t# 麟龄, M growth speed miscellaneous ship group decline. (4) Anti-tumor effect ·· Rat transplanted tumors such as Ec, H-print, Bie 8〇, l_s, B16 and other tumor strains have a degree of inhibition side, and the swelling rate of the tumor is long, the side effects are small, and the side effects are less, and the drug can be used for a long time. Drying of plants and cockroaches (|JgustjCum chuanxj〇ng H〇rt 丨--auctnon Franch·) Stem. Weixin; Sexual temperature. Return to the classics: liver, gallbladder, pericardium. Function: blood circulation secret; qi qi stagnation; receiving stagnation of sputum indications: irregular menstruation; menstruation; postpartum stagnation leg pain 瘕 瘕 lumps Chest pain; headache and dizziness; wind and cold dampness; bruises; cancer sores. Oral: Jiantang '3~1〇g. 1. Chuan written main ingredients: This product contains vinegar (LigusWide), Ding Essential oils such as Buty_a|(4), Butylidenphthalide, etc. 2. Based on the modern pharmacology of Chuanxiong: (1) Effects on platelet aggregation: spider formation and blood stagnation In the platelet coagulation induced by Na, there is a __. The platelet function and the spider mites may affect the platelet function and the spider mites may be the synthesis of the _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ . χΑτχΑ2 bow! The small plate aggregation is significantly inhibited. (2) The effect on smooth muscle: 1〇% aqueous solution of Chuanxiong extract on the surviving rabbit's isolated uterus, can stimulate the pregnant uterus in a small amount Increased tension, 'contraction is enhanced, eventually shrinks; a large number of uterus收缩 收缩 收缩 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 辕 辕 辕 辕 辕 辕 辕 辕 辕 辕 辕 辕Can reduce the vascular resistance of the Lai Du's dog to increase the blood flow of the lower limbs of the brain and the femoral movement. The biological test, the hope part and the Chuan written sputum can inhibit the contraction of potassium chloride and epinephrine on the isolated thoracic aorta strip of rabbits. The effects of Chuan written extract, water immersion liquid ethanol immersion liquid, ethanol leaching solution and biological test on dogs, saplings, rabbits and other anesthetized animals, regardless of sputum (7) or iv have significant and lasting antihypertensive effect. Ranunculaceae plant peony (pae〇nja lactjfl〇ra pALL=pa丨P·) removes the dried roots of the cork. Bitter; acid; slightly cold. Return to the classics: liver; spleen. Function: Yangm ^ Pharmacy; Emergency painkillers; Indications: irregular menstruation; abdominal pain; uterine bleeding; spontaneous sweating; night sweats; flank pain; abdominal pain; Oral 'Fried soup, 5~12g. 1. Main components of Radix Paeoniae Alba: This product contains wheat germ sterol (P-Sit〇ster〇丨), paeoniflorin (1) inositol (myoinositol), and bismuth xypae〇nifl〇rin. Benzoyl and medicinal herbs, Paeoniflongenone, etc. The roots of this genus contain gallnut tannins (Ga丨丨. 2. Modern pharmacology research basis of white peony: () antispasmodic effect. &$药# can inhibit or slow down the smooth muscle, can inhibit the spontaneous shrinkage of the isolated small intestine of guinea pigs, reduce its tension, and inhibit the contraction of guinea pigs and rabbit isolated small intestines. There was no significant effect on the intestine contraction, but there was significant inhibition after adding licorice. (2) Baoshen transfer: the extract of rats with liver damage and ALT caused by 〇-galactosamine and fibrin Elevated, the milk extract of the body-induced milk-derived Wei-hydrogenase (SLDH) and its total anal activity increased, both of which had a certain inhibitory effect on the A. sinensis. -2 Toxin poisoning has obvious detoxification effect. (3) Anti-mutagenic transfusion effect: The extract can interfere with the enzyme activity of S9 mixture and can make benzene The metabolites of BAP are inactivated and inhibit the mutagenesis of BAp. Gallic acid (ga) and pentaphyllum (pGG) can make BAp a testimony, pGG can inhibit S9 mixture Enzyme activity. The hiding energy of Zenglin and fibrin C can affect the tumor. 15 201221135 Red peony; for the genus Paeonja vejtchii LYNCH and the dry roots of the same relatives; ; return to the liver: liver; spleen by 0 function: Zhejiang fire, blood circulation through, swelling and pain. Indications: stagnation of the amenorrhea, blood stasis, blood stasis, abdominal pain, swelling, red eyes, blood. Oral: Jiantang 4~1〇g. 1. Main components of red peony: wheat germ alcohol (P_Sit〇ster〇|), peony (Pae〇njfl〇rin), inositol (myoinositol), bismuth oxide (〇xypae〇njfl〇) Rjn), benzyl guanidine, peony ketone (Paeoniflorigenone), etc. The root of this genus contains galloin tannin (Ga丨丨〇tannin). 2. The basis of modern pharmacology research: (1) anti-blood test formation Role: red and decoction 15 2 〇 g (raw ykg for rats to gavage, so that the blood test formation time is significantly extended 'length shortened, weight loss; plastin time and white pottery The partial thromboplastin time in the soil is prolonged, the euglobulin lysis time is shortened, and the blood coagulation is significantly inhibited. (2) Anti-platelet aggregation effect · The red peony extract in vitro on epinephrine and diacetyl adenine (ADp) , Laitou snake venom (TMVA) and arachidonic acid (Μ) induced significant inhibition of platelet aggregation, and decreased platelet depletion and platelet third factor activity, and increased intraplatelet content. (3) Hepatoprotective effect · Chishao injection has obvious promoting effect on DNA synthesis of hepatocytes in vitro, and has a good effect on hepatocyte regeneration and liver function recovery. It has obvious protective effect on rat liver injury induced by D_galactosamine. Glycyrrhiza uralensis; Glycyrrhiza uralensis FISCH. and dry roots and underground rhizomes of the same genus. Sweet, flat. Return to the classics: into the spleen, stomach. Function: tonifying spleen and replenishing qi, reconciling medicinal properties, clearing away heat and detoxifying, relieving pain and relieving pain, moistening lung and relieving cough. Indications: Spleen and stomach are weak, abdominal pain is relieved, and various medicines are adjusted. Treatment of hemorrhoids, sore throat, lung laccase cough, palpitations and epilepsy. Oral: Jiantang, 18 ~ 12g. 1' Main components of licorice: This product contains Uralenic acid, Glycyrrhizic acid, Licoricone and the like. Powdered licorice with licorice (|S0|jqUjritjn), Neo lyricoliritin, Liquoric acid, Glycyrrhizin, Glycyrrhetol 'Rhamnoliquiritin, licorice Diacid (Liquiritic 16 201221135 acid) 'F〇rm〇n〇netjc, glycyrrhetinic acid (18_p_G丨ycyrrhetjnicacj(1) Glycyrrhizin (Glabrene), etc. 2. Modern pharmacology research basis of licorice: (1 The antispasmodic effect on the smooth muscle of the intestine: the use of flavonoids contained in licorice inhibits the isolated intestine of rabbits and guinea pigs, reducing the number of contractions and reducing the tension. Licorice decoction, licorice extract, FmlOO, Gan Transfer, different licorice, contact with duck secrets. (2) sedative effect: glycyrrhetinic acid 125 〇 mg / kg, inhibition of the mouse nervous system, can cause sedative 'hypnosis, hypothermia and respiratory depression Etc. (3) Anti-tumor side ····································································· Cancer and sarcoma It is also effective for oral administration. Guizhi' is the tender branch of Cinnamomum cassia BLUME and its genus genus. Xin; Gan; Guijing: Sexual temperature 'bladder; heart; lung. Function · · Wen Jinghu, sweating and dispelling muscles. Indications: cold and cold syndrome, cold headache, stroke, spontaneous sweating, hand and foot gout, stagnation, sputum. Oral: Jiantang 6~15g, large dose, available to 15~3〇g 1. Main components of cassia twig: Guizhi contains 069% volatile oil, the main component of oil is cinnamaldehyde (dnnamaldehyde) 64.75. /〇' Also benzylbenzoate, cinnamyiacetate, p-荜(^cadinene), terpene (ca丨amenene), coumarin, etc. 2. Basis of modern pharmacology research of Guizhi · (1) Antipyretic effect: cinnama丨dehyde Skin vasodilatation, antipyretic effect (2) antispasmodic effect: inhibition of the role of the central nervous system. (3) the impact on the digestive system: restrained by the rats in the water-sucking stomach caused by ulceration, promote bile secretion. (4) antibacterial effect : Inhibition of pathogenic filamentous bacteria. Gui' is the dry bark of Cinnatnonnum cassia LIUME. Xin; 201221135 Gan; heat. Returning to the kidney: kidney; spleen; heart; liver. Function: life-saving door, fire, kidney, impotence, tonic , Broken blood treatment 'Tongli closed. Indications: cold and cold, cold and abdominal pain, thirst, cold madness, pulse, cold waist and knee pain, wind itchy joint contracture, postpartum abdominal pain. Oral: Jiantang, 2~5g. 1. Cinnamon main ingredients: Cinnzey|anjn, Cinnzey丨an〇丨, Cinnamon octa (〇丨0358丨0丨8), Cinnamon 八葡萄(〇丨1110388丨0|八911]00细6),Cinnamon Post C1,Cinnamon Post B,Cinnamon Post B Grape Gan,Cinnamon Post D1,Cinnamon Post D1, Grape Gan, Cinnamon Post D2, D3, C2, C3, Cinnamon Post D2 Grape Gan , cinnamon posts C1 grape sweet. The bark of this genus contains cinnamic acid {Cinnamaldehyde). 2, cinnamon modern pharmacology research basis: (1) stomach and wind-driving agent: oral administration can be used as a stomach and wind-driven agent. There is also a significant fungicidal effect, and a mixture of 1.5% cinnamon oil and 0.5% thymol has been used to treat head lice. Cinnamaldehyde and sodium cinnamate can cause vasodilation of the decidua and increase of white blood cells in rabbits. (2) Intestinal excitatory effects: Cinnamon oil is given orally to rabbits, which can promote intestinal movement and excite the intestines. The interpretation of the intestines of the isolated rabbit intestines is an explanation for the ancient people's warm spleen and stomach. (3) Through the action. Big sputum cinnamon oil can cause uterine congestion, showing the effect of menstruation, which provides an experimental basis for the effect of ancient primordial abortion (4) for blood: cinnamon has _ inhibition of ADp induction The effect of platelet aggregation in rats, in vitro tests showed that the cinnamon decoction and methanol solution had strong anticoagulant effect. (5) Sedation: Cinnamon mice contained in cinnamon have obvious sedative effect, which is characterized by decreased spontaneous activity, excessive activity against methamphetamine (Metha_etamine), mouse tail stimulation or intraperitoneal injection of acetic acid. The method of writhing motion proves that it has an analgesic effect. Peach kernel 'Prunuspersica^BATSCH and is] is a dry plant that is a near-line plant and is endocarp. Bitter sweet; flat; non-toxic; return to the heart: heart; liver; large intestine; lung; spleen. Function: Breaking blood and fasting, smoothing and smoothing the intestines. Indications: amenorrhea; symptoms; fever, blood stasis; wind sputum; cancer; bruises; blood stasis; blood dry constipation. Oral: Jiantang, 5 6~12g. 1, the main components of peach kernel: fat-containing 'dynamic essence __-like substance, gibberellin (Gjbbe "e丨丨jn) A32, 201221135 methene cyclamate (24-Methylenecydoartanol), lemon dienol (citr〇 Stadienol), P-Sitosterol, Amygdalin, etc. 2. Peach kernel modern pharmacology research basis: (1) 祛 祛 血 blood effect: water decoction alcohol solution can make isolated rabbit ear vein blood flow Increased, there is diastolic vasodilation. Injecting arterial canine arteries can increase femoral artery blood flow and reduce vascular resistance, and directly expand the blood vessel wall. It can inhibit blood coagulation and ash dissolution. Peach kernel extract 5〇mg/m spleen Intra-arterial administration can accelerate the blood flow in the liver microcirculation of anesthetized rats and improve the microcirculation on the liver surface. (2) Anti-allergic effect. The aqueous extract of peach kernel can inhibit skin allergic antibodies in mouse serum. The production of spleen hemolytic cells in mice, oral administration of ethanol extract can inhibit the amount of pigment exudation caused by anti-Ye Qing PCA reaction (passive skin allergic reaction) in mice containing skin allergic antibodies. Suspension (C〇ryda|jSyanhUSU〇WUANG) and dry tubers of the same relatives. Bitter sweet; flat; non-toxic. Returning to the liver: liver; stomach; heart; lung; spleen. Function. Huoxue Sanzhai' 'Blood and bloody medicine. Indications: chest and abdomen pain, irregular menstruation, collapse in the dew, postpartum blood stasis, more sputum damage. Oral: Jiantang, 5 6 ~ 12g. 1, Yanhusuo main components: fans Corydalis contains Coxb-ne, Corydaline 'Tetra_〇pa丨_ne' Calvidjne, and other biological tests. Northeastern Corydalis contains purpura Stem test, purple test, tetrahydro brown chick, original piece sword Pr〇t〇pjne), hydrogenated small test (Canadine). 2. Modern pharmacological research basis of Yanhusuo: (1) analgesic: electric stimulation of mouse tail method It is proved that both Yansuo powder and Yanzhifu have significant analgesic effects. (7) Relaxation of muscles: desertification of methyl tetrahydropalmatine and tetrahydropalmatin; experiments on rabbits and isolated mice show that The muscles have a relaxing effect. () The operation of the e-system · Yanhusuo Lin has a significant expansion of the isolated rabbit heart and the body-shaped heart of the blood Tube, reduce coronary resistance and increase blood flow _. For the anesthetized coronary artery expansion for 201221135 with the most obvious 'intra-carotid artery second. The femoral artery also has a certain expansion effect. Mudanpi' is a hairy genus Peony (p〇〇aeonja suffrutjcosa andr_) and the same relatives of plants are stripped of the dried root bark of the wood. Hard; cold; slightly cold. Returning to the heart: heart; liver; kidney; lung. Function: heat and dampness 'Cool blood, and blood, treatment. Indications: typhoid fever, poisonous hair spots, standing enterprises, vomiting blood, blood in the stool, 'menopausal' bone steaming heat, 'swelling, gold sores. Oral: Jiantang, 6~9g. 1. Main components of peony bark: This product contains peony age (paeon〇l) and Benz〇yl Paeorii florin. 2, Mudanpi modern pharmacology research basis: (1) cardiovascular effects: peony skin on the anesthetized dog can increase the coronary flow A flow, reduce cardiac output, reduce the role of left ventricular work. It has obvious protective effect on experimental myocardial ischemia and lasts for a long time, while reducing myocardial oxygen consumption. Peony phenolphthalein.5_1Og/kg also showed a certain decrease in renal hypertensive dogs and rats; 1 effect. (2) Anticoagulant effect: In vitro, the human platelet woven 'discovered the water extract of peony bark and the peony can inhibit the platelet arachidonic acid to produce arachnoid A2, thereby inhibiting platelet aggregation, which is due to inhibition of steroid acid The result of the cyclooxygenase reaction to the prostate H2. The methanol extract of peony bark has an inhibitory effect on experimental thrombosis caused by endotoxin. Achyranthes; is the dry root of Achyranthes bidentata BLUME and the same relatives. Also known as Bai Yu ("Pharmaceuticalization"). Bitter, sour, and flat. Into the liver; kidney. Li Yue San Zhai blood / Xiao swollen pain, liver and kidney, strong bones and muscles. Indications: Blood Zhaihu Zhizhi's dysmenorrhea, amenorrhea, symptoms, and production of tanning clothes, 'abdominal pain, and itchy throat, bruises, waist and knee pain, limbs and pain. Oral: Jiantang, 5 ~ structure. 1. The main components of Achyranthes: Ecdysterone, Astragalus sterol (|n〇k〇sterone), etc. 2, Achyranthes modern pharmacology research basis: (1) the impact on the heart: the achyranthes extract on the body of the baby, anesthetized cats have a certain inhibitory effect, water, the agent on the anesthetized dog myocardium is more obvious . (2) Effects on animal strength: Achyranthes decoction has a short-term antihypertensive effect on anesthetized cats and dogs. 201221135 When the pressure drops, it is accompanied by a female, and the silk is quickly tolerated. It is associated with histamine release, cardiac suppression, and expansion of peripheral gold tubes. Safflower; a dry petal of the comfrey (CarthamustinctoriusUNN). Wei Xin; temperature. Return to the classics: into the heart, · spleen; stomach. Function: activating blood circulation; secret pain. Indications: amenorrhea; dysmenorrhea's postpartum abdominal pain; cellulite heartache syndrome accumulation; bruises and injuries alone; stroke hemiplegia; Oral: Jiantang ‘ 3~1〇g.匕 匕 匕 · 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 2, safflower modern pharmacology research basis: (1) inhibition of the heart: safflower decoction a small dose can make the heart and rabbit in the heart of the heart slightly excited 'to make the heart beat powerful' amplitude; large doses have inhibition of the heart The heart rate is slowed down, the myocardial contractility is weakened, and the cardiac output is reduced. (2) Red: anti-coagulation effect of 匕 色素 色素 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛 帛() Antihypertensive effect. The safflower and safflower yellow pigments provide different degrees of rapid antihypertensive effect on anesthetized cats. The average blood pressure drops by about 2 minutes Hg and lasts for about 3 minutes. (4) Effect on the uterus: The safflower decoction has an excitatory effect on the isolated uterus of mice, mice, rabbits and dogs. The uterus secrets of the system, the mouse, and the smoked surface. Wulingzhi is a fecal feces of the vertebrate squirrel orange squirrel (trogoptems xanthipes MILNS-EDWARDS). Taste bitter; sweet; sexual temperature; return to the liver; spleen. This is a good way to stop bleeding. Indications: dysmenorrhea, women's amenorrhea, postpartum blood stasis, insect bites. Oral: Jiantang, 5~1〇g. 1. The main components of Wulingzhi: dry feces of polydentate rats, pyrophoric tea (pyr〇catech〇丨), benzoic acid (benZQicadd), 3,-9,1()_2_ (3_caren- 9 ,10-dicarb〇xylic acid) Urinary hall (urcj|), Wulingsic acid (10)丨jn_cadd) m-hydroxybenzoicadd 'protocatechujcadd', hypoxanthine 201221135 (hypoxanthing ) 'Allantoin (a||ant〇in). 2, Wulingzhi modern pharmacology research basis: (1) the impact on the cardiovascular system: Wulingzhi 2〇mg/kg femoral artery injection increased anesthesia dog femoral artery blood flow, vascular resistance decreased. Wulingzhi aqueous extract 200ug/ml can significantly reduce the oxygen consumption of rat cardiomyocytes in vitro. (2) • Anticoagulant effect: Wulingzhi aqueous extract 2 〇g/m丨 has enhanced fibrinolysis in vitro. (3). The effect on the uterus: Wulingzhi decoction has a short-term tension on the isolated rabbit palace, and returns to normal after a few minutes, and some after the occurrence of inhibition, but little effect on frequency and amplitude. In vitro tests have shown that Wulingzhi has different degrees of inhibition on Mycobacterium tuberculosis and various dermatophytes; it also has the effect of relieving flat sphincter spasm and has been used clinically for angina pectoris. Puhuang; dried caterpillar of the genus Typhaangustifolia LINN. and related plants. Sweet, slightly sympathetic; Hide: ^; liver; miscellaneous. H is used for the use of Zhai Li, urine, and the charcoal is used to stop bleeding. Indications: Health - treatment of menstrual cramps, postpartum obstruction for pain, bloody, faint adverse 'beating damage' bloated. Stir-fry with _ treatment of uterine bleeding, bring out the gold disease: external treatment of trauma, fish treatment. Oral: Jiantang, 5~10g. 1 Pu K main ingredient. Broadleaf cattail contains glucose, rhamnose, xylose and other oligosaccharides. 2, Puhuang modern pharmacology research basis: % (1) on the uterus and intestinal smooth muscle: 50% Puhuang injection on the guinea pig isolated uterus and rabbits in the body uterus are excited. The small 継 継 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬 酬Its mechanism may be related to the direct increase of uterine contractions and hemostasis. The isorhamnetin contained in Puhuang has an antispasmodic effect on the isolated intestinal tube of mice. (2) Effects on the cardiovascular system: Puhuang extract has a significant effect on increasing coronary flow in isolated rabbit hearts. It also has an improvement effect on myocardial microcirculation in mice. (3) The effect on the coagulation process: Puhuang can increase the blood of rabbits, the number of plates increases, the time of thrombin is shortened, and the blood coagulation time is obviously shortened. Puhuang cooked with charcoal can increase hemostasis. Puhuangzhong 22 201221135 The scutellaria compound (rutin, quercetin, etc.) has a hemostatic effect. Myrrh; for the eucalyptus plant myrrh tree (commiphora oil, bitter; flat. return: liver; spleen; heart; kidney. Function: blood to go to two pain. Main smelting _, face, sputum, hand Age _ 目目. Oral 1 soup, 3~10g.

1、沒藥主要成分:沒藥樹含樹脂25〜35%,揮發油2 · 5〜9%,樹膠約57 〜65。/。’此外為水分及各種雜質約3〜4%。樹脂的大部分能溶於喊,不溶 性部分含a及B罕沒藥酸’可溶性部分含a B與r沒藥酸、沒藥尼酸、a盘 B罕沒藥盼。尚含罕沒藥樹膠質沒藥脂、沒_醇。揮發油在空氣中易樹 脂化,含丁香油盼、間苯甲盼、祕、蔽稀、二觸、檸檬稀、桂祕 沒藥烯等。 2、沒藥現代藥理學研究依據: ⑴收斂侧:沒藥_對賊有收斂侧,口腔'咽部潰鱗可用於口腔 洗劑中;亦可用于胃腸無力時以興奮腸螺動。 (2)抗炎、鎮痛與退熱作用:沒藥的多種同屬植物均被發現有抗炎等作用。 如沒藥的油樹脂石油趟提取物,可明顯抑制角叉菜膠與棉球肉芽腫所致炎 症’小鼠也有明顯的退熱作用。 小茴香;為繳形科植物後香(Foeniculum vulgare MILL.)之乾燥成熟果 實。味辛;性溫。歸經:肝;腎膀胱;胃經。功能:燥腎溫胃,散寒止痛, 暖丹田’補命門。主治:寒痛,腎寒小腹痛,調中止嘔,乾濕腳氣,蛇傷, 消化不良,為芳香健胃藥。内服:煎湯,3〜6g。 1、 小@香主要成分:含甲基胡椒齡(Methylchavicol),茵香酸(Anisicacid), 甲基異丁香油酚(Methyljsoeugnol),蒎烯(α-,β-Pinene),月桂烯 (β-Myrcene),水芹烯(a - Phellandrene),順茴香腦(cis-Anethole)等揮發油, 及硬脂酸(Stearic acid),山藩s奴Behenic acid)等形成之臘。 2、 小®香現代藥理學研究依據: 23 201221135 (1)對胃腸運動的影響:小茴香對家兔在體腸蠕動有促進作用+ 鼠離體腸管有興奮個,紐增高_現__,鬆麵腸^香腦對小 亦無反應。鬆他作用約為黑粟域的25%,菌香腦約為28%, 1醜鹼 菌香賴為4% ’檸檬稀約為2%,桉葉油素約為1%。揮發 勺 回腸縱行肌肌束,增強其收縮,EC50為6-7Mg/m|。 '用於脉鼠 ⑵對肝的侧:對部分肝摘除大鼠,給條揮發油1Q天, 加,肝的重量比對照組增加。 曰 ⑶性激素樣侧:雄大鼠給小浸出物15天电、輪精管的 白含量減少’精翼和前列腺的總蛋白則明顯增加,這些器官的龜、雜 酸酶活性降低;軟鼠麟崎出物1Q天,出現陰勒肖___ 乳腺.管、子宮内膜、子宮肌層重量增加,認為小爾雌激素樣作用。 乾、生簦’為薑科植物薑(Zjngjber 0ffjcjna|e R〇sc)之乾燥根莖辛 熱^歸經:歸脾、胃、心、肺經。魏:溫愤寒,鳴舰,溫肺化飲i 主/口 .幹薑溫中散寒’回陽綱^ ’燥濕消痰。用於腚腹冷痛,·池萬,肢 冷脈微’痰飲喘咳。内服:煎湯,3〜1〇g。 1、量主要成分:新鮮本品含蒎烯(p_pinene),月桂烯(Myrcene),芽子烯 (Y-Selinene) ^ ii|(Nonanol) , Sesquiphellandrene). m 素(Gingero丨)’薑帖酮(Zingjber〇ne),_(ζ_「_,墓湘_阳「卽)等 精油。 2'薑現代藥理學研究依據: ⑴鎮痛作用:各組小鼠分別生薑精油、度冷丁和冑容量吐溫鹽水,給藥後 具顯著鎮痛侧,生《有顯著的鎮痛作用。 (2)對血小板凝集作用·對於ADp (他⑽丨几誘導的兔的血小凝集,& 薑醇僅在肖濃度下才呈域抑制作用 。但對花生四烯酸(160umol/L)誘發 的血小板凝集’ 6-薑醇具有明顯抑制作用。 ^菌、獅、蟲作用:生薑的水浸出劑對傷轉菌、絲弧菌、堇色癖菌 24 201221135 及陰道滴蟲均有不同程度的抑制作用。 白定;為繳开4科植物白芷(Angelica dahurica BENTH. et HOOK. var. pai~chi KIMURA,HAYATAet YEN)。味辛;性溫;歸經:歸肺;脾,·胃經。 功能:頭面諸痛疾,接風,消腫’排膿,止痛。主治:頭痛,眉稜骨痛,齒 痛,鼻淵,寒濕腹痛,腸風得漏,赤白帶下,癍疽瘡癌,皮膚燥疼,齋癬。 内服:煎湯,3〜10g。 1、 白芷主要成分:白芷或興安白芷含新白當歸酮(Angelico丨)紫花前胡甘元 (Marmesin〉。近屬白芷含當歸酮(Angelicol)等夫喃香豆素衍生物 • (Furocoumarin Derivatives) 〇 2、 白芷現代藥理學研究依據: ⑴解痙作用.白芷含佛手柑内酯、花椒毒素、異歐前胡素乙對兔回腸具有 明顯的解痙作用。異歐前胡素還能增加兔子宮的收縮力和_丨肌的緊張性。 東莨菪素對雌激素或氯化鋇在體或離體大鼠子宮痙攣有解痙作用。 (2) 解熱鎮痛侧:用蛋白腺皮下注射於大白兔背部造成的高熱動物模型,, g白芷或杭白芷煎劑15g/kg,有明顯的解熱作用。 (3) 對心血官的作用:本品所含的異歐前胡素和印度棍梓素對貓有降血壓的 作用。異歐前胡素與N-乙烯吡咯烷酮的共聚物可使貓動脈壓降低,還能降 低離體娃心的收縮力。 (4) 抗癌作用:異歐前胡素和自當歸素具有對He|a細胞的細胞毒作用。 紫蘇:為唇形科植物皺紫蘇(Peri丨丨a frutesens (L) BR|Tr varoispaemUNBJHAND-MAZZ ·)之乾燥葉(或帶嫩枝)。味辛;性溫。歸經: 歸肺;脾;胃經。魏:錄縣’行氣寬中,、;肖_肺,定吼喘,安胎, 解魚蟹毒。紫蘇梗專於理氣。主治:傷風頭痛,發熱,胸舰滿,咳嗽,氣 喘,胎氣不和,乳癰腫痛,金瘡出血,食蟹中毒。内服:煎湯,5〜1〇g。 1、紫蘇主要成分:皺紫蘇全草含揮發油,包括紫蘇駿(perj丨丨a丨触作),紫 蘇(Shisonin),白蘇烯®ii(Eg_ket〇n),左旋棒樣稀(|_Li_ene),α姻 25 201221135 (α-Pinene) ° 2'紫蘇現代藥理學研究依據: (1) 解熱作用:用紫蘇葉煎劑及浸劑2g/kg經口服傷寒混合菌苗發熱的家 兔’有微弱的解熱作用。 (2) 對血凝的作用:紫蘇水提液對家兔耳表靜脈注射,可縮短血凝時間、血 漿複妈時間和凝血活酶時間,紫蘇内源性凝血系統有促進作用。 ⑶促進腸蠕動:紫蘇葉中分離出的perilia ketone,對大鼠有促進腸蠕動作 用,使腸内物質運動加速,對腸擴約肌有刺激作用。 ⑷鎮靜作用:紫蘇葉中分離出的紫蘇酿、Stjgmasterd、Dj|| apj0|e均有鎮 鲁 靜作用,可延長苯巴比妥減少的大鼠的睡眠時間,紫蘇水煎劑’ :2〇濃度, 對病毒ECH011株有抑制作用。 人參;為五加科植物人參(pANAX G丨NSENG c a meyer)去鬚根之乾燥 根。味苦;微苦;性微溫。歸經:腎經;肺;脾經。功能:大補元氣’益陰 血,生津,補肺,安神。主治:勞傷虛損,強心救脫,食少倪怠,氣短喘促, 肢冷汗出’大麟泄’驚悖健忘,眩暈頭痛,陽萎,尿頻,消渴,婦女崩漏, 小兒慢驚及久虛不復,一刀氣血津液不足之證。内服:煎湯,3〜15g。 1、人參主要成分:鮮人參、白參主含三;^皂武。根觀元的不同,可分為 二類.屬齊墩果酸類的,有人參皂武(gjnsen〇side)_R〇 ;屬原人參二醇粗的,鲁 有人參皂甙-Ra1、-Ra2、-Ra3 ' -Rb1、Rb2、-Rc、Rd、Rg3,西洋參皂 sUquinguenosideHRl、RC;屬人參三醇類的,有人參息武你、 -Rf、-Rg1、 -Rg2、Rh1 ’ 20-葡萄糖人參皂甙⑵咖网化的⑽地㈣,三七息甙 (n〇t〇gi_0side)-R1' R4叫。還含多炔類成發:人參炔醇(panaxyn〇|), 人參環氧炔醇(panaxydol)、鐮葉芽醇(fa|cgrjn〇丨),又含揮發油其中成分 有倍半Μ ’長纖和繼何、量料涵,解議是主魏分有:時 -β 人參烯(panasinsene),丁香稀(cary〇phy|_|ene),β_金合麟 (β famesene) ’ α-和 β-新丁香三環烯(ne〇c|〇vene),α 和 ρ 葎草烯 26 201221135 (humulene),α-、β-和γ-芹子烯(於叱卽句,芹子二,丁 香烯醇(caryophyllene alcohol),雙環大槐牛兒烯(bicyd〇grmacrene),$ 和β-愈創木稀(guaiene) ’ α-蓽澄祐油烯(a_cUbebene),β-廣藿香烯 (β-patchoulene),佛術烯(eremophj丨ene),α_、爲_和γ視香烯(e丨七阳阳), β-甜沒藥烯(β-bisabolene),α-香撥稀(a-aromadendrene), α-和 β-檀香萜 稀 santalene) ’ α-和 β-畢澄茄烯(cadinene),β_撖禮稀(p_maa|iene),麥 由酮(mayurone),喇叭茶醇(ied〇|)等;又從揮發油中分得具抗癌活性的二 十碳烯酸(eicosenoicacid) ’含量高達2.37%。 φ 2、人參現代藥理學研究依據: ⑴功能的_ :人參或其提取物對骨髓的造&魏有保護和刺激作 用’能使正常和貧血動物紅細胞數、白細胞數和血紅蛋白量增加。對貧血病 人也能使紅細胞數、血紅蛋白和血小板增加。 (2) 對金小板功能的作用:人參具有抑制血小板聚集的作用。給健康成人空 腹口服紅參粉1.5g,服後彳和3小時抽血測定血小板雜,結果與服藥前 概’其對花生四烯酸、ADP、凝血.腎上腺素等誘發的血小板聚集有顯 著的抑制作用’同時由花生四稀酸和凝血酶誘導的血小板丙二链的生成也受 • 到抑制。比較紅參和白參的70%甲醇提取物在體外對兔血小板聚集的抑制 作用。 (3) 杬腫瘤伽.人參巾含有的多種μ '人參錄及人轉發油具有抗腫 Μ乍用』參巾人參域能使癌細胞再分化、解逆轉為非癌細胞。人參莖 葉總私可抑制體外培養人胃癌細胞的生長速度和分裂能力,增加細胞内糖 原含量’降低細胞内粘多鮮^性鱗酸酶活性,起到—定的阻礙胃癌細胞生1. Myrrh main ingredients: Myrrh tree contains 25~35% resin, 2~5~9% volatile oil, and about 57~65 gum. /. In addition, it is about 3 to 4% of moisture and various impurities. Most of the resin can be dissolved in the shout, the insoluble part contains a and B rare myrrhic acid. The soluble part contains a B and r myrrhic acid, myrrhic acid, and a plate B. It still contains rare myrrh tree gum, no drug, no alcohol. Volatile oil is easy to be lipidated in the air, containing clove oil, expectation of benzophenone, secret, thinning, two-touch, lemon thin, mystery, and myrrh. 2, myrrh modern pharmacology research basis: (1) convergence side: myrrh _ thief has a convergence side, oral 'pharyngeal ulcer scale can be used in oral lotion; can also be used for gastrointestinal weakness when excited intestines snail. (2) Anti-inflammatory, analgesic and antipyretic effects: Many of the same genus plants of myrrh have been found to have anti-inflammatory effects. For example, the oleoresin petroleum scorpion extract of myrrh can significantly inhibit the inflammation caused by carrageenan and cotton granuloma. The mice also have obvious antipyretic effects. Fennel; dry and ripe fruit of the genus Foeniculum vulgare MILL. Wei Xin; temperature. Return to the classics: liver; kidney bladder; stomach. Function: dry kidney warm stomach, cold and pain, warm Dantian's life door. Indications: Cold pain, kidney cold and abdominal pain, adjustment of vomiting, dry and wet athlete's foot, snake wound, indigestion, aroma and stomach medicine. Oral: Jiantang, 3~6g. 1. Xiao@香 Main ingredients: Methylchavicol, Anisicacid, Methyljsoeugnol, Terpene (α-, β-Pinene), Myrcene (β- Myrcene), a-Phellandrene, volatile oil such as cis-Anethole, and wax formed by stearic acid, behenic acid, etc. 2, Xiao® Xiang modern pharmacology research basis: 23 201221135 (1) Effects on gastrointestinal motility: cumin promotes the intestine peristalsis in rabbits + Excited in the isolated intestines of the mouse, the new increase _ now __, Song noodles ^ Xiang brain did not respond to small. The effect of pine is about 25% of the black millet, the scent of the scent is about 28%, the ugly base is 4%, the lemon is about 2%, and the eucalyptus is about 1%. Volatile spoon The ileal longitudinal muscle bundle enhances its contraction with an EC50 of 6-7Mg/m|. 'For the mouse (2) on the side of the liver: For some of the liver-extracted rats, the volatile oil was given for 1Q days, and the weight of the liver was increased compared with the control group.曰(3) Sex hormone-like side: Male rats gave small extracts for 15 days, and the white content of the round spermatozoa decreased. 'The total protein of the fine wing and prostate increased significantly, and the activity of turtles and acylases decreased. 1Q days of emergence, the emergence of Yin Lei Xiao ___ breast. Tube, endometrium, myometrial weight increased, considered a small estrogen-like effect. Dry, oysters' is the dried roots of Zingiberaceae plant (Zjngjber 0ffjcjna|e R〇sc). Hot heat: returning to the spleen, stomach, heart, lung. Wei: Wen anger cold, Ming ship, Wenfeihua drink i main / mouth. Dry ginger Wenzhong dispelling cold 'return to Yang Gang ^' dry and dry. For cold pain in the abdomen, · Chi Wan, limbs cold pulse micro 痰 喘 drinking asthma. Oral: Jiantang, 3~1〇g. 1. The main components: fresh this product contains terpene (p_pinene), myrcene, Y-Selinene ^ ii| (Nonanol), Sesquiphellandrene). m (Gingero丨) 'Ginger (Zingjber〇ne), _ (ζ_"_, 墓湘_阳"卽) and other essential oils. 2 'Jiang modern pharmacology research basis: (1) analgesic effect: each group of mice respectively ginger essential oil, degree cold and sputum capacity spit Warm saline, after administration, has significant analgesic side, and has a significant analgesic effect. (2) Platelet agglutination · For ADp (he (10) 诱导 several induced rabbit blood agglutination, & ginger alcohol only in the concentration It has a domain inhibitory effect, but it has a significant inhibitory effect on arachidonic acid (160umol/L)-induced platelet aggregation of '6-gingerol. ·Bacteria, lions, and insects: ginger water leaching agent Vibrio cholerae, sputum bacillus 24 201221135 and vaginal trichomoniasis have different degrees of inhibition. Baiding; to pay for 4 families of plants (Angelica dahurica BENTH. et HOOK. var. pai~chi KIMURA, HAYATAet YEN ). Wei Xin; sexual temperature; return to the lungs; spleen, · stomach. Function: head pain, take the wind Detumescence, drainage, pain relief. Indications: headache, eyebrow pain, toothache, nasal pain, cold and damp abdominal pain, intestinal wind leakage, redness, acne cancer, skin pain, fasting. Jiantang, 3~10g. 1. Main ingredients of white peony: Baiji or Xing'an white peony contains Angelica sinensis (Marselin sinensis). Nearly white peony contains Angelicol and other fragrant coumarin derivatives. • (Furocoumarin Derivatives) 〇2, Baiji Modern Pharmacological Research Basis: (1) Antispasmodic effect. Baiji contains bergamot lactone, xanthotoxin and isoimperatorin B. It has obvious antispasmodic effect on rabbit ileum. It can increase the contractility of the rabbit palace and the tension of the diaphragm. The scorpion has an antispasmodic effect on estrogen or strontium chloride in the uterus of the body or in vitro. (2) Antipyretic and analgesic side: subcutaneously with protein glands Injected into the high-heat animal model caused by the back of the white rabbit, g gypsum or Hangbai simmer decoction 15g / kg, has obvious antipyretic effect. (3) The role of the blood of the blood: the product contains the iso-euricin and India The effect of scorpionin on blood pressure in cats The copolymer of imperatorin and N-vinylpyrrolidone can reduce the arterial pressure of the cat and reduce the contractile force of the isolated body. (4) Anticancer effect: isoimperatorin and self-administration have He| The cytotoxic effect of a cell. Perilla: a dried leaf (or twig) of the genus Periaceae freses (L varoispaem UNBJHAND-MAZZ ·). Wei Xin; temperature. Return to the classics: return to the lungs; spleen; stomach. Wei: Recording County's qi is wide, and; Xiao_Lung, Dingchuanchuan, Antai, and fish and crab. Perilla stems are dedicated to qi. Indications: cold headache, fever, chest full, cough, asthma, fetal gas is not, chylorrhea, pain, gold sore bleeding, crab poisoning. Oral: Jiantang, 5~1〇g. 1, the main components of perilla: wrinkled perilla whole grass contains volatile oil, including perilla (perj丨丨a丨 touch), perilla (Shisonin), white sulene® ii (Eg_ket〇n), left-handed bar-like (|_Li_ene) , α marriage 25 201221135 (α-Pinene) ° 2 'Purple modern pharmacology research basis: (1) Antipyretic effect: the use of perilla leaves decoction and infusion 2g / kg oral typhoid mixed vaccine fever rabbit 'weak Antipyretic effect. (2) Effect on blood coagulation: Perilla aqueous extract can reduce the time of blood coagulation, the time of blood stasis and the time of thromboplastin, and the endogenous coagulation system of perilla can promote the blood stasis. (3) Promoting intestinal peristalsis: Perilia ketone isolated from perilla leaves promotes intestinal peristalsis in rats, accelerates intestinal material movement, and stimulates intestinal sphincter. (4) Sedative effect: Perilla, Stjgmasterd, Dj|| apj0|e isolated from perilla leaves have a calming effect, which can prolong the sleep time of rats with reduced phenobarbital. Perilla decoction ' : 2〇 The concentration has an inhibitory effect on the virus ECH011 strain. Ginseng; dried roots of the roots of the ginseng (pANAX G丨NSENG c a meyer). Bitter; slightly bitter; sexually lukewarm. Return to the classics: kidney; lung; spleen. Function: Dabu Yuanqi 'Yiyin blood, Shengjin, lungs, soothe the nerves. Indications: labor injury, strong heart rescue, eat less Ni Kuang, shortness of breath, cold sweats, 'Da Linxie', convulsions, forgetfulness, dizziness, headache, impotence, frequent urination, thirst, women uterine bleeding, pediatric slowness And long time no longer, a knife of blood and fluid deficiency. Oral: Jiantang, 3~15g. 1, the main components of ginseng: fresh ginseng, white ginseng contains three; ^ soap. According to the difference of root Guanyuan, it can be divided into two categories. It is an oleanolic acid, ginseng saponin (gjnsen〇side) _R〇; it is a crude ginseng diol, and ginsenoside-Ra1, -Ra2, - Ra3 '-Rb1, Rb2, -Rc, Rd, Rg3, American ginseng soap sUquinguenosideHRl, RC; ginseng triols, ginseng you, -Rf, -Rg1, -Rg2, Rh1 '20-glucose ginsenoside (2) Coffee networked (10) land (four), three seven interest (n〇t〇gi_0side)-R1' R4 called. It also contains polyacetylenes: panaxyn〇|, panaxydol, fa|cgrjn〇丨, and volatile oils, which contain sesquiterpenes After the hoisting, the main Wei points are: time-beta ginsengene (panasinsene), cloves thin (cary〇phy|_|ene), β_金合麟(β famesene) 'α- and β-new Clove tricycloolefin (ne〇c|〇vene), α and ρ humene 26 201221135 (humulene), α-, β- and γ- celery (in Haiku, celery II, syringol ( Caryophyllene alcohol), bicyt 〇 〇 〇 mac bic bic bic bic bic bic bic bic bic bic bic bic gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua gua , eremophj丨ene, α_, _ and γ-decene (e丨七阳阳), β-bisabolene, α-aromadendrene, Α- and β-santalene santalene) 'α- and β-cadinene, β_撖_稀(p_maa|iene), mayurone, trumpet tea (ied〇| ); and from the volatile oil to obtain anti-cancer activity The content of eicosenoic acid is as high as 2.37%. φ 2. Modern pharmacological research basis of ginseng: (1) Functional _: ginseng or its extract has protective and stimulating effects on bone marrow production and ampere-, which can increase the number of red blood cells, white blood cells and hemoglobin in normal and anemia animals. It also increases the number of red blood cells, hemoglobin and platelets for anemia patients. (2) Effect on the function of gold platelets: Ginseng has the effect of inhibiting platelet aggregation. For healthy adults, fasting oral red ginseng powder 1.5g, taking sputum and 3 hours of blood to determine platelet impurities, the results and before taking the drug, it has significant platelet aggregation induced by arachidonic acid, ADP, coagulation and adrenaline. Inhibition' At the same time, the formation of platelet-propylene propylene-chain induced by peanut tetrazoic acid and thrombin is also inhibited. The inhibitory effect of 70% methanol extract of red ginseng and white ginseng on rabbit platelet aggregation in vitro was compared. (3) 杬 tumor gamma. Ginseng towel contains a variety of μ 'human ginseng and human forwarding oil has anti-tumor 』 ginseng ginseng ginseng domain can re-differentiate cancer cells, reversal into non-cancer cells. The total ginseng stem and leaf can inhibit the growth rate and cleavage ability of human gastric cancer cells in vitro, increase the intracellular glycogen content, reduce the activity of glutamate in the cells, and prevent the gastric cancer cells from dying.

L f二雜皂祕齡亦有—糊_作用。人 f5刀揮毛/由成刀使體外培養的胃癌和肝癌細 制、死亡癌細胞數目增加。 玍长又W 黃耆,為且科植物内蒙黃耆(Astraga丨us _gh〇丨丨cus bung印膜英黃 27 201221135 耆(Amenbranaceus (FISCH.) BUNGE)及同屬近緣植物之乾燥根。甘;溫。 歸經:心;肺;脾;腎經。功能:補脾益氣;生用固表止汗,生肌,排腹内 託,炙用補中益元氣’升陽生血。主治:胃下垂,子宮下垂,氣虛灰脫,帛 漏,脫肛。内服:煎湯,6〜15g。 1、 汽耆主要成分:含刀豆氨酸(l__Canavanine),膜莢黃耆含大豆皂甘乙 (SoyasapogenolB) ’ 黃耆皂甘丨〜vni(Astragalosidel〜VIII),異黃耆皂甘丨 〜VI(lsoastragaloside I〜VI) ’ 環黃耆皂(Cycloastragenol)。 2、 黃耆現代藥理學研究依據: ⑴對心臟血管系統影響:本品水浸液或醇提取物使家兔血壓顯著降低,其 降壓作用不受切斷兩側頸部迷走神經或先用阿托平(a_at「〇pjne)處置影響,其 降壓作用與直接擴張末稍血管有關。 (2)對腸管f彡響:本。純浸賴天竺_體顿細魏縮作用。 ⑶對性週期影響:本品水浸液引發雌性大白鼠動情期。 白朮;為菊科植物白朮(Atractylodes macrocephala KOIDZ)之乾燥根 莖。味苦;甘;性溫。歸經:歸脾;胃經。功能:補胖,益胃,燥濕,和中, 止篇止斤’利尿。主治.消化不良,不思飲,倦怠少氣,虛脹泄濱,浮腫, 胃内停水,黃錄庳,小便不利,頭暈,自汗,胎氣不安。内服:煎湯,3 〜15g。 1、 白求主要成分:含揮發油,内有士及卜鮮稀(h__|ene),禮香醇 (P~elemol) ’ α 薑黃烯(a_cUrcumene),蒼術酮(a tract|〇ne),邓·乙醜氧 基蒼術酮(3p-aCet〇xyatr_〇ne),芽子二稀酮[se丨丨加丨咖各_ ’按葉 醇(eudesmol) ’ 棕摘酸(pa|mitiCacid),茅術醇(hines〇|),β_芽子稀 (β-selinene)等。 2、 白朮現代藥理學研究依據: ⑴抗腫瘤作用:體外表Β月,白求揮發油中之中性油對食管癌細胞有明 顯抑制作用,mcg/m丨時,於24小時内可使癌細胞全部脫落。 28 201221135 癌有顯著抑制作用 ml時’可使大部分癌細胞脫落,殘存的小片細胞或散在細胞呈核固縮核 仁_騎,泡f多空泡。白轉發油5_mg/kg麵注射對艾氏腹水 ()抗疑血作用.白求對血小板聚集有明顯的抑制作用,白求煎劑〇59/吻 灌胃Μ周,此顯著延長大鼠凝血酶元的時間。 …木香;為軸錄廣木香(Sa_「ea丨appa CURKE)之乾雜。味辛,· 言,性皿。歸級:歸肝;胃;驗。功能:健脾和胃,疏肝解營,行氣止痛。L f di-powder soap also has a paste-effect. Human f5 knife swaying hair / by the knife to increase the number of cancer cells and cancer cells in vitro cultured in vitro.玍长和W Astragalus, is a dry root of the Astraga丨us _gh〇丨丨cus bung imprinted yellow 27 201221135 A (Amenbranaceus (FISCH.) BUNGE) and the same relatives. Warming: heart; lung; spleen; kidney. Function: spleen and qi; raw solid table antiperspirant, raw muscle, abdominal support, sputum with Buzhong Yiyuan qi 'shengyang blood. Indications: The stomach is drooping, the uterus is drooping, the qi is gray off, the sputum is leaking, and the anus is taken. Oral: Jiantang, 6~15g. 1. The main components of the car sputum: containing edulis (l__Canavanine), the capsule scutellaria containing soy saponin (Soyasapogenol B) ) 'Astragaloside l ~ VIII, Astragalosidel ~ VIII (lsoastragaloside I ~ VI) 'Cycloastragenol. 2, Astragalus modern pharmacology research basis: (1) Cardiovascular system effects: The product's aqueous extract or alcohol extract significantly reduces the blood pressure of rabbits, and its antihypertensive effect is not affected by the vagus nerve on both sides of the neck or the treatment with atop (a_at "〇pjne"). The antihypertensive effect is related to the direct expansion of the peripheral blood vessels. (2) The intestine tube f彡: Ben. Pure Lai Tianqi _ body body fine Wei contraction. (3) impact on the sexual cycle: the product of the infusion caused by the female erotic phase. Atractylodes; for the Atractylodes macrocephala KOIDZ dry stems. bitter; sweet; Warm. Return to the spleen; stomach spleen. Function: make up fat, benefit stomach, dampness, and in, stop the end of the pound 'diuretic. Indications. Indigestion, do not think about drinking, burnout and less gas, vain venting, Puffy, water in the stomach, Huang Luyu, urinary unfavorable, dizziness, spontaneous sweating, fetal uneasiness. Oral: Jiantang, 3 ~ 15g. 1, Bai Qi main ingredients: containing volatile oil, inside the sir and dilute (h__| Ene), P~elemol 'α curcumene (a_cUrcumene), atractyl ketone (a tract|〇ne), Deng · ugly atractyl ketone (3p-aCet〇xyatr_〇ne), bud two Dilute ketone [se丨丨 plus 各 各 _ 'by leaf alcohol (eudesmol) 'brown picking acid (pa|mitiCacid), echinoyl alcohol (hines〇|), β_ buds thin (β-selinene), etc. 2 , Atractylodes modern pharmacology research basis: (1) anti-tumor effect: in vitro, phlegm, white oil in neutral oil for esophageal cancer cells is obvious In the case of mcg/m丨, the cancer cells can be completely shed within 24 hours. 28 201221135 Cancer has a significant inhibitory effect. When ml is used, most of the cancer cells can be shed, and the remaining small cells or scattered cells are nucleated and nucleated. Ren _ riding, bubble f more empty bubble. White forwarding oil 5_mg/kg facial injection on Ehrlich ascites () anti-suspicious blood effect. Baiqi has a significant inhibitory effect on platelet aggregation, Baiqi decoction 〇59/ kiss gavage periorbital, which significantly prolongs rat thrombin Yuan time. ... woody; for the axis recorded Guangmuxiang (Sa_"ea丨appa CURKE) dry miscellaneous. Weixin, · words, sex dish. Classification: liver; stomach; test. Function: spleen and stomach, liver lysis Camp, qi and pain.

主治:胸_ ’兩賴,呕吐赠’痢疾裡急後重,膀胱冷痛,疝氣。 内服··煎湯,1.5〜9g。 1'木香主要成分:含木香烯_(Castun〇|ide),脫氮木香内酯 (Dehyd_stus 丨actone) ’ 木酬 c〇stene),禮香稀(β 日e_e),芽子 烯(P~Sehnene) ’二氫木香内酯(Djhydr〇c〇stun〇丨jde),風毛菊内酯 (Saussurea lactone),無羈帖(Friedelin)等烯帖類(terpen〇ids)精油。 2、木香現代藥理學研究依據: ⑴對〜血管的作用.低濃度的木香揮發油及從揮發油中分離出的内醋部分 能抑制豚鼠與鱗如臟齡動’鱗航,純有抑制作用。 (2)對腸道的作用:木香水提液、揮發油和總生物驗對小鼠離體小腸先有輕 度興奮作用’隨後緊張性與節律性明顯降低。對乙續驗、組胺與氣化鎖所 致腸肌痙攣有對抗作用。 (3)對呼吸系統的作用:豚鼠離體氣管與肺灌流實驗證明,木香水提液、醇 提液、揮發油及總生物鹼能對抗組胺與乙酰膽鹼對氣管與支氣管的解痙作 用。揮發油中所含總内酯、木香内酯、二氫木香内酯等内酯成分以及去内酯 揮發油均能對抗組胺、乙酿膽驗與氣化鋇引起的支氣管收縮作用,其中以二 氫木香内酯作用較強。 获茶;為多孔菌科植物茯茶(Poria cocos (Schw·) Wolf)的乾燥菌 核。味甘、淡,性平。歸經:入心、脾、肺經。功能··渗濕利水、益脾和胃、 29 201221135 寧心安神。主治:小便不利、水腫脹滿、痰飲咳逆、噁心嘔吐、泄瀉、遺精、 淋濁、驚悸、健忘。内服:煎湯,9〜15g。 1、 茯苓主要成分:主要含β_茯苓聚糖(p_pachy man),約占幹重的93%, 和二萜類化合物获茶酸(Pachymicacid)、土牧酸(Tumulosicacid)、三萜叛 酸(Triterpene carboxylic acid)、齒孔酸(Eburioic acid)、松苓酸(Pinicolic acid) 等。亦含脂肪酸’如辛酸(Caprylicacid)、Η一酸(Undecanoic acid)、月桂 酸(Laurieacid)、十二酸(Dodecenoicacid)和棕橺酸(Palmiticacid)。 2、 茯苓現代藥理學研究依據: ⑴對消化系統的影響:茯苓對家兔離體腸管有直接鬆弛作用,對大鼠幽門 結’、所形成的潰瘍有預防效果,並能降胃酸。另對CCI4所致大鼠肝損傷有 明顯的保護作用’使穀丙轉氨酶活性明顯降低,防止肝細胞壞死。 (2)抗腫瘤作用:茯苓中的主要成分為茯苓聚糖(pachyman),對小鼠肉瘤 S180的抑制率可達9β 88%。 結梗;為桔梗科植物桔梗(Platycodon grandifl〇mm(JACQ.)A. DC.)除去 外皮之乾燥根。味苦;辛;性平。歸經:歸肺;胃經。功能:利胸腸,溫中。 主治:外感咳漱,咽喉腫痛,祐痰排膿,肺癰,胸滿肋痛,菊疾,腹中痛。 内服:煎湯,3〜10g。 [桔梗主要成分:含遠志酸㈣知洫比沘叫’抬梗酸甲們邮娜⑽娜 A),桔梗皂甘元(Ratycodigenin),桔梗酸乙、丙,桔梗甘丙(Ratyc〇side 〇, 先桔梗皂甘(Prosapogenin)。 2、桔梗現代藥理學研究依據: ⑴接痰與鎮咳作用:麻醉犬口服本品煎劑_,能顯著增加呼吸道枯液 的分泌量,其強度可與氣化錄相比。對麻醉猶亦有明顯的接痰作用。能抑制 小氣自發性活動’延長環己巴比妥納的睡眠時間。 (2)抑制胃液分泌和抗潰瘍作用:粗制桔梗息武在偷^1/5半數致死量的劑 量時有抑制大鼠胃液分泌和抗消化性潰瘍作用。1〇〇mg/kg継時,幾乎能 201221135 完全抑制大鼠幽門結紮所致的胃液分泌。 ⑶對循環系統的作用:大鼠以粗制桔梗皂甙靜脈注射,可見暫時性血壓下 降,心率減慢和呼吸抑制。 厚朴;為木蘭科植物厚朴(Magnolia 0fficjna|SREHDERet WILSON)及 同屬近緣植物之乾燥樹皮。苦;辛;性溫。歸經:脾;胃;大腸經。功能: 溫中’下氣,散滿,燥濕,消療,破積,益胃腸。主治:胸腹脹滿作痛呕 吐’瀉痢’喘咳。内服:煎湯,3〜10g。 1、 厚朴主要成分:樹皮含木脂體類化合物:厚朴酚(magnolol),和厚朴齡 (honokiol) ’ 和厚朴新紛(〇b〇vat〇|),6’-〇_ 甲基^口厚朴盼(6,— O-methylhonokio丨)’厚朴搭(magna|dehyde) B、C,厚朴木脂體 (magnolignan) a、b、◦、d、E 及臺灣檫木醛(randainai);單萜木脂體 類化合物:辣薄荷基厚朴酚(卩丨阼吻丨⑴印⑽⑻雙辣薄荷基厚朴酚 (dipiperitylmagnolol) ’辣薄荷基和厚樸酚pjperity|h〇n〇kj〇|)及龍胞基厚朴 酚(bomylmagnolol);降木脂體類化合物:臺灣擦木盼(randi〇|),厚朴三 SHmagnatriol) B,厚朴盤D、E ;雙木脂體類化合物:厚朴木脂體F、G、 Η及丨;生物驗:木蘭箭毒域(magn〇cura_和柳葉木蘭域㈣c眺e); 揮發油:含30多種成分。 2、 厚朴現代藥理學研究依據: ⑴降A壓作用:_重2u 7kg)/只’靜脈注射厚朴域加咖,血壓下 降約20mmHg,持續約10分鐘。 (2)抗腫瘤作用:厚朴曱醇提取物和厚朴_體内二触癌細丨起的小鼠 皮膚腫瘤有明顯的抑制作用。 ⑶血小板聚集的抑制作用:厚朴酴與和厚朴盼抑制膠原和花生四稀酸誘導 的兔富血械轉的轉和ATP職,触的劍销概富到、板血毁 的聚集更明顯彳皮抑制。 大棗;為鼠李科植物大棗__ jujuba町泊「丨議丨$ (赃) 31 201221135 REHD·)之乾燥成熟果實。甘;溫。歸經:胃;脾經。功能:用安中養脾, 平胃氣’調營衛,和百藥。主治:飲食減少,反胃吐食,泄萬,津液不足, 過敏性紫斑病。内服:煎湯,9〜15g。 1、 大棗主要成分:棗果實含生物驗:光千金藤域(st印har-ine),N_去甲 基荷葉域(N_n_dferine),[賴(asmilGbine);巾性及離多醣,黏 液質,環單碟酸腺甘(Cyclic AMP)。 2、 大棗現代藥理學研究依據: ⑴抗腫瘤作用:MNNG處理大鼠後,長期喂給中藥大棗似有降低胃腸道惡 性腫瘤發生率的作用。對__18q增殖的抑制作用從大棗分離得到的三 莊類化合物中進一步分離出游離型、酯活性的樺木酸、山楂酸,對匕35%肉 瘤一180增殖有抑制效果’特別是山楂酸,有61%的抑制效果,比5_Fu 抑制率更強。 (2)對中樞神經的抑制作用:採用延長硫喷妥鈉作用作為指標,發現大棗内 苯曱醇糖甙、柚配質(糖甙等多種化合物)具有顯著降廢作用,對中樞神經 有抑制作用。 大腹皮;為棕橺科植物檳榔(Areca catechu LINN·)之乾燥成熟果皮。味 辛;性微溫。歸經:脾;胃;大、小腸經。功能:下氣寬中,行水,通大小 腸。主治:痞脹痰膈’水腫腳氣’小便不利,霍亂。内服:煎湯,5〜彳〇g。 1、 大腹皮主要成分:本品含生物驗,檳榔驗(Arecoline),槟榔次驗 (Arecaine) ’檳榔副驗(Arecolidine),去甲基檳榔驗(Guacoline)。胺基酸,苯 内氨酸(Phenylalanine) ’ 脯氨酸(Proline)。脂肪酸類;硬脂酸(stearic acjd), 癸酉曼(Capricacid)。皁寧類;兒茶精(Catechin)’原矢車菊(Pr〇cyanidin)B1、 B2、B7,檳榔單寧(Arecatannin)A1、A1、A2、B2。 2、 大腹皮現代藥理學研究依據: (1)中樞作用:本品檳榔驗(arecoline)於貓靜脈注射出現各種自律經症狀, 有刺激腦幹樣體,活化皮質腦波作用。 32 201221135 (2)平滑肌作用:檳榔驗與毛果芸香驗(p||〇var^ne)有相近作用,使腸管平滑 肌強力收縮,增加腸管緊張性及運動性,收縮瞳孔平滑肌作用。 陳皮;為芸香科植物甜樹Citrussinensis(L)OSBECK).及同屬近緣植物 成熟果質之新鮮或乾燥外果皮。苦、辛,溫。歸經:歸肺、脾經。功能:調 中,理氣,導痰,利水;統治百病,皆取其理氣燥濕之功。主治:下氣消食, 止。區逆,化痰破結,止吐丨寫,利小便。内服:煎湯,3〜10g。 1、 陳皮主要成分:甜橙外果皮含川陳皮素(Nobjietjn),五甲基黃顯|(3",4", 5 ’ 6 ’ 7-Penta~0-Methylflavone) ’ 橙皮甘(HCSpCriaine),新橙皮甘 (Meohesperidine),檸檬烯(Limonin) ’庚基壬基亞苦烯(0(七印以丨_尽_ nonylacrolein)等。酸镫外果皮含羥基奥蘭酮(5_Hydr〇xyauranet丨n),橙皮甘, 檸檬烯,柚皮甘(Naringin),野漆樹甘川(RhOifolill),月桂烯(Myrcene),聚 傘花素(P-Cymene) 〇 2、 陳皮現代藥理學研究依據: (1) 對消化系統的作用:陳皮所含揮發油,對胃腸道有溫和刺激作用,可促 進消化液的分泌,排除腸管内積氣,顯示芳香健胃和驅風下氣的效用。 (2) 對心血管系統的作用:陳皮煎劑、醇提物能興奮心肌,劑量過大時反而 出現抑制。可使血管產生輕度的收縮’迅速升高血壓。陳皮中的果膠對高脂 飲食引起的動脈硬化也有一定的預防作用。 ⑶對呼吸系統的作用:陳皮所含揮發油有刺激性被動祛痰作用,使瘦液易 D各出。陳皮,¾劑對支氣管有微獅擴張侧。其醇提_平喘效價較高。 半夏麵;為天南星科植物半夏(pine丨丨a temata(THUNB )BRE丨丁)及同屬 近緣植物去外皮之乾燥根莖。味辛;性溫;有毒。歸經:脾;胃n功 月b .燥濕化痰,降逆止嘔;消痞散結。主治:咳喘痰多;嘔吐反胃;胸聢癌 滿頭痛眩暈;夜臥不安;癭瘤痰核;癰疽縣。内服:煎湯,3〜9g。 1、半夏麴主要成分.含麥胚固醇(β一Sitosterol),膽驗(Choline),麥胚 固醇葡萄甘(β (β-Sito stcryl) D-gluoDside),氨基丁酸(β-Aminobutyric 33 201221135 acid)。 1礬研究赠:鎮_,_、_、姜浸半夏和 财作用,M,對触液注入胸腔或電刺激喉上神經所致的咳嗽有明顯的 二田且可維持5小時以上。〇.6_的鎮咳作用接近於可待因丨mg/kg 的作用。 為。幵v 科植物藿香(Agastache rugosa RSCH. et MEY 〇 K^TZE^娜之乾觸。料:罐•聯亦胃經。 、丨、氣和中’益胃氣,利齡風,開胃止喂。主治:消化不良,霍亂吐 逆痢疾喉殫’咳漱,口臭,胃寒而引起之吐渴、腹或胸闊等。内服:煎 湯,6〜1〇g 〇 、 1、着香主要成分:着香她由,甲基胡椒酚(MgthylChavio^,D_#檬烯 (· onene),蒎烯(a_ppjnene) ’茴香醛(An丨阳丨触炸),芳掉醇 ( )石竹烯(CaryoPhy丨丨ene),律草烯(β-Humluene)及黃鹼素類藿香 甘(Agastachoside)等。廣藿香含倍半帖類(sesqujterpene),廣藿香奥醇 (Pogostol)及其他精油。 、 ' 藿香現代帛理钟究依據:_像㈣織 m水提液令具有 對@離子的拮杬活性成分’其水提液對κ+攣縮具有抑制活性。廣藿香用於 治療消化不良、Μ、賴和纽不振,消化H官肌_過触縮可能是唱 吐和腹4的u卩分賴’目此離抗舰過降低經細胞咖的〇32+流量來控 制平滑肌綱度興奮,躺鋼離這些症狀。 熟地η、生地黃,為玄參科植物地黃(Rehmannia (gaertn ) UBOSCH)經加工處理之乾燥根或根^味甘;性^。歸經:歸肝;腎經。 功能.鮮生地-清火涼金,止吐趣,療溫病,用作解熱藥。乾生地-補真陰, 凉血,.、、用作滋養強壯藥。主治:鮮生地_溫病傷寒,虛勞骨蒸,咳漱唾血, /肖渴,胁血’婦人崩中及產後灰上薄心,悶絕傷身,胎動下企,胎不落,堕 墜腕折’齋血’便秘。乾生地·血虛發熱,消渴,虛勞吐血,鼻魈,胞漏下 34 201221135 血’便秘。内服:煎湯,10〜30g。 地η主要成刀.熟地黃含較少量的環稀鱗阻類成分,已分離得到:益母 草^咖_,桃葉珊瑚甙(麵bin),懷慶地黃根含水蘇糖⑻南咖), a草糖(Verbascose) ’ 根莖含梓醇(α^φοί),地黃武(rehmannj〇sjcje) C D美利妥雙戒(阳丨丨卜㈣由),地黃素(伯⑽印丨此心、〇,地 黃氣化臭蟻醛甙(gluti-noside)等。 2、地黃現代藥理學研究依據: ⑴熟地黃延緩小鼠衰老的作用··熟地黃2〇%水煎液每日灌胃〇制共45 癱天’取血’測定超氧化物歧化酶(s〇D)、過氧化氫酶(cat)、谷胱甘肽過 氧化物酶(GSH-Px )活力和過氧化脂質(Lp〇 )的含量。熟地可增強GSH_px 活性和降低金清中LP〇的含量’與對照組相比較分別為p<〇 〇5和 P<0.01。 (2)熟地黃補血作用的實驗觀察:生、熟懷地黃水煎劑灌喂給於小鼠觀察對 失血性貧血、造血幹細胞和骨髓紅系造血祖細胞CFU_E生成的影響。生、 «地黃f佚血性小綠明_侧,制是熟地黃織復較快。 黃答;為唇形科植物黃荼(Scutellaria baricalensis GE0RGI)及同屬近約 植物之乾馳。味苦;性寒H歸肺;^ ;肝;膽;大驗。功能:填 φ 實火’解熱渴,利小腸,止企安胎。主治:風熱濕熱頭痛,熱漱喉腥,定喘 漱只殖,血熱,吐、紐、崩、漏,目赤腫痛,乳癰,發背。對於些呼吸道, 急性支氣管炎,配桑白皮。内服:煎湯,3〜9g。 两今主要成分.含黃驗素類(Flavonoids),並頭草黃驗(Skullcapflavone), 漢育芩素(Wogonin ) ’黃芩素(Baicalein),木蝴蝶素甲(〇roxy|jn a),白楊素 (Chrysin),5-漢黃芩(Wogonin5|D>glucoside)及麥胚固醇(sitosterol)等。 2、黃芩現代藥理學研究依據: ⑴抗病毒作用:黃芩煎劑25-100%濃度,體外試驗對乙型肝炎病毒dNA 複製有抑制作用。 (2)抗菌作用:黃芩煎劑100〇/〇濃度’對痢疾桿菌、傷寒桿菌、副傷寒桿菌、 35 201221135 B)' mm '(a > 产可桿峨抑軸。黃铜試管峨1⑽0濃 肺炎雙球菌及福氏痢疾桿菌、人結核 又?:=_球菌B ’ m < 補⑴7 1.32Q濃度可抑制霍亂弧 ^⑽細也i : 8Q濃度時宋内氏触爾抑制伽。黃答醇浸 液〇._細_ ’㈣雜培養,驗與培養基彳:彳混合 :菌有抑制作用。黃答醇浸液_濃度,平皿法麵對大腸桿菌、插草 、金黃議__咖。料煎劑、醇提劑1g/m丨濃度,用平 板法武驗時對腦膜炎球菌均有抑作用。Indications: Chest _ ‘Two Lai, vomiting and giving 痢 痢 里 里 里 里 , , , , 膀胱 膀胱 膀胱 膀胱 膀胱 膀胱 膀胱 膀胱Oral and decoction, 1.5 to 9g. 1 'woody main ingredients: containing wood ene _ (Castun 〇 | ide), denitropyrrolidone (Dehyd_stus 丨actone) 'wood reward c〇stene), ritual thin (β day e_e), germinated (P~Sehnene) 'Dhydrogen eugenol (Djhydr〇c〇stun〇丨jde), Saussurea lactone, Friedelin and other terpen〇ids essential oils. 2, woody modern pharmacology research basis: (1) the role of ~ blood vessels. Low concentration of woody volatile oil and the internal vinegar part separated from the volatile oil can inhibit guinea pigs and scales such as dirty ages, the scales, pure inhibition . (2) Effects on the intestine: the wood perfume extract, volatile oil and total bioassay have a slight excitatory effect on the isolated small intestine of the mouse. Then the tension and rhythm are significantly reduced. It has an antagonistic effect on the intestinal myopathy caused by continuous test, histamine and gasification lock. (3) Effects on the respiratory system: The guinea pig isolated trachea and lung perfusion experiments have shown that the wood extract, alcohol extract, volatile oil and total alkaloid can counteract the effects of histamine and acetylcholine on the trachea and bronchi. The lactones such as total lactone, licolactone, dihydroxylactone and volatile oils in the volatile oil can resist the bronchoconstriction caused by histamine, acetylcholine and gasification phlegm. Dihydrocostus lactone has a stronger effect. Obtained tea; dried sclerotium of Poria cocos (Schw·) Wolf. Sweet, light, and flat. Return to the classics: into the heart, spleen, lung. Function ··Draining water, spleen and stomach, 29 201221135 Ning Xin An Shen. Indications: dysuria, edema, phlegm, nausea, vomiting, diarrhea, nocturnal emission, turbidity, convulsions, forgetfulness. Oral: Jiantang, 9~15g. 1. Main components of cockroaches: mainly containing β-glycan (p_pachy man), accounting for 93% of dry weight, and diterpenoids obtained from Pachymic acid, Tumulosic acid, and triterpenoid acid ( Triterpene carboxylic acid), Eburioic acid, Pinicolic acid, and the like. It also contains fatty acids such as Caprylic acid, Undecanoic acid, Laurie acid, Dodecenoic acid and Palmitic acid. 2, 茯苓 modern pharmacology research basis: (1) the impact on the digestive system: 茯苓 has a direct relaxation effect on the isolated intestine of rabbits, has a preventive effect on the pyloric junction of the rat, and can reduce stomach acid. In addition, it has obvious protective effect on liver injury induced by CCI4, which can significantly reduce the activity of alanine aminotransferase and prevent hepatocyte necrosis. (2) Anti-tumor effect: The main component of sputum is pachyman, and the inhibition rate of mouse sarcoma S180 can reach 9β 88%. Knot; remove the dried roots of the rind for Platycodon grandifl〇mm (JACQ. A. DC.). Taste bitter; Xin; sex flat. Return to the classics: return to the lungs; stomach. Function: Lee chest, warm. Indications: exogenous cough, sore throat, sputum drainage, lung sputum, chest full of rib pain, chrysanthemum disease, abdominal pain. Oral: Jiantang, 3~10g. [The main components of platycodon grandiflorum: containing polygalic acid (four) knowing 洫 洫 ' 抬 抬 抬 抬 抬 抬 抬 抬 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( 10 ( 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 First, Plasmodium sinensis (Prosapogenin). 2. Modern pharmacology research basis of Platycodon grandiflorum: (1) Conjunction and antitussive effect: Anesthetized dog oral decoction _, can significantly increase the secretion of respiratory tract liquid, its intensity can be recorded with gasification Compared with anesthesia, it also has obvious joint effect. It can inhibit spontaneous activity of small gas and prolong the sleep time of cyclohexabarbital. (2) inhibit gastric juice secretion and anti-ulcer effect: crude platycodon is stealing The dose of ^1/5 half lethal dose inhibited the secretion of gastric juice and anti-peptic ulcer in rats. When 1〇〇mg/kg継, it can almost completely inhibit the secretion of gastric juice caused by pylorus ligation in rats. (3) Circulation The role of the system: rats with intravenous platycodon saponins intravenous injection, showing temporary blood pressure drop, heart rate slowdown and respiratory depression. Magnolia; Magnolia 0fficjna|SREHDERet WILSON and the same relatives Dry bark Bitter; Xin; Sexual temperature. Return to the classics: spleen; stomach; large intestine. Function: Wenzhong 'under gas, full, dampness, treatment, broken, benefit the stomach. Indications: chest and abdomen full of pain and vomiting 'diarrhea 'Wheezing. Oral: Jiantang, 3~10g. 1. Main ingredients of Magnolia: Bark containing lignan compounds: magnolol, and hnokiol' and Houpu Xinfen (〇 B〇vat〇|),6'-〇_ methyl^口厚朴盼(6,—O-methylhonokio丨)' Magpu|dehyde B, C, magnolignan a, b, ◦, d, E and Taiwan eucalyptus (randainai); eucalyptus lignans: menthol menthol phenol (卩丨阼 丨 (1) 印 (10) (8) double peppermint xylophenol (dipiperitylmagnolol) ' Spicy mint base and magnolol pjperity|h〇n〇kj〇|) and cytoplasmic phenolic powder (bomylmagnolol); lignin-like compound: Taiwan ruby wood (randi〇|), Magnolia three SHmagnatriol) B, Magnolia D, E; double lignans: Magnolia sylvestris F, G, sputum and sputum; biological test: Magnolia arrow poison domain (magn〇cura_ and willow magnolia field (four) c眺e); Hair oil: contains more than 30 ingredients. 2, Magnolia modern pharmacology research basis: (1) A pressure reduction: _ weight 2u 7kg) / only intravenous injection of Magnolia plus coffee, blood pressure drop of about 20mmHg, lasting about 10 minutes. (2) Anti-tumor effect: Magnolia sinensis extract and Magnolia sinensis have a significant inhibitory effect on skin tumors in mice. (3) Inhibition of platelet aggregation: Houpu and Heshang expect to inhibit the transfer of collagen and peanut tetrazoic acid-induced rabbit blood-rich machinery and ATP jobs. Suede inhibition. Jujube; jujube plant jujube __ jujuba town mooring "丨 丨 赃 $ (赃) 31 201221135 REHD·) dry and ripe fruit. Gan; warm. Return: stomach; spleen. Function: use Anzhong Raise the spleen, flat stomach gas 'tune camp Wei, and 100 medicine. Indications: diet reduction, nausea and vomiting, ventilating, lack of fluid, allergic purpura. Oral: Jiantang, 9~15g. : Jujube fruit contains bioassay: light jin vine domain (st har-ine), N_demethyl lotus leaf domain (N_n_dferine), [Lai (asmilGbine); towel and polysaccharide, mucilage, ring single disc acid gland Cyclic AMP 2. The basis of jujube modern pharmacology research: (1) Anti-tumor effect: After MNNG treatment of rats, long-term feeding of Chinese jujube seems to reduce the incidence of gastrointestinal malignant tumors. Inhibition: The free-form, ester-active betulinic acid and behenic acid were further isolated from the Sanzhuang compound isolated from jujube, and had an inhibitory effect on the proliferation of 35% sarcoma-180, especially behenic acid, with 61% inhibition. The effect is stronger than the 5_Fu inhibition rate. (2) The inhibition of the central nervous system: mining Extending the action of thiopental as an indicator, it was found that the phenyl sterol glycoside and the pomelo plastid (glycoside and other compounds) in the jujube had significant anti-waste effect and inhibited the central nervous system. Dry beetle of plant betel nut (Areca catechu LINN·). Weixin; sexually lukewarm. Return: spleen; stomach; large and small intestine. Function: lower air, water, large and small intestine. Indication: inflation痰膈 'Oedema athlete's foot urinary adverse, cholera. Oral: Jiantang, 5 ~ 彳〇g. 1, the main components of the big belly skin: this product contains biological test, Arecoline, Arecaine (Arecaine) 'betel nut Arecolidine, Guacoline. Amino acids, Phenylalanine 'Proline. Fatty acids; stearic acjd, Capric acid ) saponin; catechin Catechin 'Pr〇cyanidin B1, B2, B7, Arecaannin A1, A1, A2, B2. 2. Modern pharmacology research basis of large belly skin : (1) Central role: this product is beacon test (arecoline) in the cat intravenous injection Symptoms of self-discipline, stimulate brainstem-like body and activate cortical brain waves. 32 201221135 (2) Smooth muscle function: Betel nut test and hairy fruit aroma test (p||〇var^ne) have similar effects, making intestinal smooth muscle strong contraction It increases the tension and motility of the intestine and shrinks the smooth muscle of the pupil. Chenpi; Citrussinensis (L) OSBECK), and the fresh or dried exocarp of the mature fruit of the same relatives. Bitter, Xin, warm. Return to the classics: return to the lungs, spleen. Function: Tune in, qi, guide, and water; rule the disease, all take the power of qi and dampness. Indications: Dissipate the gas, stop. District reversal, phlegm and phlegm, stop vomiting, and urinate. Oral: Jiantang, 3~10g. 1. The main components of dried tangerine peel: sweet orange exocarp containing nobjietjn, pentamethyl yellow (|3",4", 5 '6 '7-Penta~0-Methylflavone) 'HCSpCriaine , Neohesperidine, Limonin 'heptyl decyl sulfene (0 (seven seals 丨 _ _ nonylacrolein), etc.. The citrus exocarp contains hydroxy olanzanes (5_Hydr〇xyauranet丨n ), orange peel, limonene, naringin, RhOifolill, Myrcene, P-Cymene 〇2, Chenpi modern pharmacology research basis: (1) The role of the digestive system: the volatile oil contained in dried tangerine peel has a mild stimulating effect on the gastrointestinal tract, which can promote the secretion of digestive juice, eliminate the accumulation of gas in the intestine, and show the effect of aroma and stomach and wind and gas. (2) For the cardiovascular system Function: Chenpi decoction, alcohol extract can excite the myocardium, and when the dose is too large, it will inhibit. It can cause mild contraction of blood vessels and rapidly increase blood pressure. The pectin in dried tangerine peel also has certain arteriosclerosis caused by high-fat diet. Preventive effect. (3) Effect on the respiratory system: Chen The volatile oil contained has a stimulating passive sputum effect, which makes the lean liquid easy to D. The tangerine peel, 3⁄4 agent has a micro-lion expansion side on the bronchi. The alcohol extract_antiasthmatic titer is higher. Pinellia ternata; Pinellia (pine 丨丨ata (THUNB) BRE )丁) and the same roots of the same plant to the outer stem of the dried roots. Wei Xin; temperature; toxic. Return: spleen; stomach n power month b. dampness and phlegm Indications: cough and phlegm; vomiting and nausea; chest cancer full of headache and dizziness; night restlessness; sputum sputum nucleus; 痈疽县. Oral: Jiantang, 3~9g. Main components of Pinellia ternata. Containing wheat germ sterol (β-Sitosterol), Choline, β-Sito stcryl D-gluoDside, aminobutyric acid (β-Aminobutyric) 33 201221135 acid). 1矾 Research grant: town _, _, _, ginger soaked in the summer and the role of money, M, injecting fluid into the chest or electrical stimulation of the laryngeal nerve caused by the cough has obvious Ertian and can maintain More than 5 hours. The antitussive effect of 〇.6_ is close to that of codeine 丨mg/kg. For the 幵v family plant musk (Agastache rugosa RSCH. et MEY 〇 K^TZE^Na's dry touch. Material: cans • Lianyi stomach. 丨, qi, and Zhong 'Yiqi, Lilingfeng, appetizing and feeding. Indications: indigestion, cholera vomiting dysentery throat cough Hey, bad breath, thirst caused by stomach cold, abdomen or chest wide. Oral: Jiantang, 6~1〇g 〇, 1, the main ingredients of the fragrance: fragrant her, methyl pepper phenol (MgthylChavio^, D_# limene (· onene), terpene (a_ppjnene) 'anisaldehyde ( An 丨 丨 丨 ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) Class (sesqujterpene), Polygonol (Pogostol) and other essential oils. , ' Musk modern remedy based on: _ like (four) woven m water extract with an antagonistic active ingredient for @ ions' water extraction The liquid has inhibitory activity on κ+ contracture. Patchouli is used to treat indigestion, sputum, sputum and stagnation, and digestive H official muscle _ over-traction may be sputum and abdomen 4 The ship has reduced the 〇32+ flow rate of the cell coffee to control the excitability of the smooth muscles, and the steel is away from these symptoms. The rehmannia η, Rehmannia glutinosa, is the dried root of the processing of Rehmannia (gaertn UBOSCH) Or root ^ sweet; sex ^. Return to the liver: kidney; kidney. Function. Fresh raw land - clear fire and cool gold, stop the fun, treat the disease, use as antipyretic. Health - supplement yin, cool blood, .,, as a nourishing and strong medicine. Indications: fresh land _ warm disease typhoid, virtual bone steaming, cough and blood, / Xiao thirst, threatening blood 'women collapse and postpartum gray On the thin heart, suffocating the body, the fetal movement under the enterprise, the tire does not fall, the squatting wrist folding 'Zhai blood' constipation. Dry soil, blood deficiency, fever, thirst, vomiting blood, nasal discharge, cell leakage 34 201221135 Blood 'Constipation. Oral: Jiantang, 10~30g. The ground η is mainly formed into a knife. Rehmannia glutinosa contains a small amount of ring-dark scale resistance components, which have been isolated: Motherwort ^ coffee _, peach leaf coral 面 (face bin), pregnant Qingdi Huanggen water-containing threose (8) Nanca), a grass sugar (Verbascose) 'The rhizome contains sterol (α^φοί), Dihuangwu (rehmannj〇sjcje) CD Meridian double ring (Yangshu Bu (four) by ), emodin (Bo (10) printed this heart, sputum, rehmannia gas odor aldehyde gluten- aldehyde (gluti-noside), etc. 2. Rehmannia modern pharmacology research basis: (1) Rehmannia glutinosa delays the role of aging in mice · · Rehmannia glutinosa 2〇% decoction daily gavage for a total of 45 瘫 days 'take blood' determination of superoxide dismutase (s〇D), catalase (cat), glutathione The activity of the enzyme (GSH-Px) and the content of lipid peroxide (Lp〇). The rejuvenation can enhance the GSH_px activity and reduce the content of LP〇 in the Jinqing' compared with the control group, p<〇〇5 and P<0.01, respectively. 2) Experimental observation of the effect of Rehmannia glutinosa on blood enrichment: The effects of raw and cooked Rehmannia glutinosa decoction on mice were observed to affect the formation of CFU_E in hemorrhagic anemia, hematopoietic stem cells and bone marrow erythroid hematopoietic progenitor cells. Health, «Dimensional Yellow f bloody small green Ming _ side, the system is rehmannia rehmannia complex faster. Yellow answer; is the scutellaria plant Scutellaria baricalensis GE0RGI and the same genus. Bitterness; sexual cold H to the lungs; ^; liver; gallbladder; Function: Fill in φ real fire's solution to thirst, benefit small intestines, stop the enterprise and fetus. Indications: wind, heat, dampness, headache, hot throat, Dingchuan, colonization, blood heat, vomiting, New Zealand, collapse, leakage, red eyes and swelling, chyle, hair back. For some respiratory tracts, acute bronchitis, with mulberry white skin. Oral: Jiantang, 3~9g. The main ingredients of the two today. Containing Flavonoids, Skullcapflavone, Wogonin 'Baicalein, 蝴蝶roxy|jn a, Poplar Chrysin, 5-gonactone (Wogonin 5 | D > glucoside) and wheat germosterol (sitosterol). 2, Huangqi modern pharmacology research basis: (1) antiviral effect: Huangqi decoction 25-100% concentration, in vitro test for hepatitis B virus dNA replication inhibition. (2) Antibacterial effect: Huangqi decoction 100〇/〇 concentration 'on dysentery bacillus, typhoid bacillus, typhoid typhoid bacillus, 35 201221135 B) 'mm '(a > production can be controlled by axis. Brass test tube 峨 1 (10) 0 thick Pneumococcal and Shigella dysenteriae, human tuberculosis again?: = _ cocci B ' m < supplement (1) 7 1.32Q concentration can inhibit cholera arc ^ (10) fine also i: 8Q concentration when Song Nei contact inhibition gamma. Alcohol immersion liquid _._fine _ '(4) miscellaneous culture, test and culture medium 彳: 彳 mixed: bacteria have inhibitory effect. Yellow glycol immersion liquid _ concentration, plate method to face E. coli, grass, golden __ coffee. The decoction and alcohol extracting agent concentration of 1g/m丨 can inhibit the meningococcal bacteria when tested by the plate method.

⑶+取、血管的作用:黃答醇提液1g/kg 兴今烈劑0.06g/kg靜脈注射,對麻醉犬有明顯降壓作用。 (4)保肝、利膽 '抗氧化:黃荅甲醇提取物舰注射,對異硫氛酸蔡峨叫 引起的大鼠肝損害有抑制作用,可抑制血清膽紅素的增加。黃雜提物% , 黃芩甙50 ’灌胃,對家兔有利膽個。漢黃答素濃度體 外微’對大鼠肝微粒體脂質過氧化有抑制作用,使丙二齡(MDA)含量下 梔子,為茜草科植物檐子樹(Gardenia jasmjn〇ides ELUS angustifoha NAKAI)及其他同屬近緣植物成熟乾燥果實。苦;寒。歸經:心; 肝’肺’胃’二焦經。功能:清熱,丨;|火,涼血,能使心肺之熱屈曲下行, 從小便出。主治:心煩不眠’黃疸,淋病,口渴,目赤,頭痛,吐血 9 jfeftjia., 濕熱身黃(傳染病性肝炎、血清性肝炎)。内服:煎湯,5〜1〇g。 1、 振子主要成分:含鳶尾類(Ifidoid glyceside),去經振子(Jasminoidin、 Geniposide),羥基檐子(Gardenoside),振子平-1-β-龍膽二糖 (Genipine>1 -p~gentiobioside)梔子新(Gardoside)等。 2、 梔子現代藥理學研究依據: (1)鎮痛作用:梔子甙及其水解產物京尼平對腹腔注射醋酸引起的小鼠扭體 36 201221135 運動有抑制作用。 ί > :縣料職祕管研鎌子及其不酿取物對大 鼠膽胰机里魏酶活性的影響’振子及其幾種提取物有明顯的利姨、利膽及 降騰酶賴' 〇 ()肝臟的保護作用:】21丨CR大鼠預先(24或站小時以前)給於檐子提取 物,可防止因半乳糖胺弓丨起的暴發性肝炎 黃連,為毛茛科植物黃連(Coptis chjnensjs FRANCH)、家黃連(c teeta WAUJCH)及同屬近緣植物除去鬚根之乾燥根莖。苦;寒。歸經:心;肝; 月大腸經。功能:离火,燥濕,殺蟲。主治:時行熱毒,傷寒,熱盛心煩, 癌滿區逆,菌痢,熱厲腹痛,肺結核,下血,消渴,舟積,鮰蟲病,百日咳, 因侯腫痛’口瘡’癍疽瘡毒,濕療,湯火费傷。内服:煎湯,15〜3g。 1、 κ連主要成分:黃連根莖含小蘗驗(Berberine),棕摘鹼(Palmatine)。家 黃連根莖含小蘗鹼,黃連鹼(Coptisine)及脫曱基防已驗(Jateorrhizine) 〇 2、 黃連現代藥理學研究依據: (1) 抗炎、抗腹瀉作用:黃連曱醇提取物對雞受精卵,有抑制肉芽組織增生 的作用’鹽酸小檗域灌胃’對大鼠巴豆油囊法、棉球法表現有抗炎作用。 (2) 對心血管作用:小檗域3_5mg/kg靜脈注射,可使麻醉犬金壓下降如 動物預先用麥角毒處理,則小檗域的降壓作用可被翻轉。 (3) 解熱作用:黃連注射劑靜脈注射對家兔白細胞致熱原性發熱有解熱作 用,並使腦脊液中cAMP含量下降。 (4) 抗菌作用.黃連烈劑100/〇》辰度,平皿法實驗表明對病疾病桿菌、傷寒 桿菌、副傷寒桿菌、霍亂孤菌、大腸桿菌、變形桿菌等7種革蘭氏陰性菌及 葡萄球菌、a-溶血性鏈球菌、B-溶血性鏈球菌、肺炎雙球菌、百曰咳桿菌等 5種革蘭氏陽性菌皆有較強的抑菌作用。 (5) 抗病毒作用:黃連煎劑50%濃度0.1ml/蛋,雞胚法試驗表明對流感病毒 PR8株、曱型流感病毒56~S8株、亞曱型病毒FM丨株、乙型流感病毒^ 37 201221135 株、内验流感病毒1233株均有抑制作用。黃連煎齊j 25-100%濃度對乙型肝 炎病毒DNA有抑制作用。 皮樹(P chinensis SCHNEID·)及同屬近緣植物除去外表之乾燥樹皮。苦; 寒°歸經··腎;膀胱經。功能··填火解毒,清熱燥濕,瀉腎火(多用於下焦 濕熱症’亦肖於腎火完盛所致之骨蒸潮熱,盜汗,遺精等)。主治:濕熱帶 下’臭穢黃稠者’濕熱黃疸,濕熱下注,足膝腫痛,足萎軟,皮膚濕熱,濕 毒’濕療’骨蒸潮熱,盜汗,遺精。内服:煎湯,3〜9g。 1、 κ柏主要成分:黃蘗樹皮含小蘗驗(Berberine),少量生物驗,掠搁鹼 (Palmatine) ’ 木蘭花驗(Magnoflorine),黃蘗驗(Phellodenfrine),含無氮 鲁 素之結晶性物質;黃蘗酮(〇bacun〇ne),及脂肪’固醇類化合物等。臺灣 黃蘗含小蘗鹼約3%。 2、 黃柏現代藥理學研究依據: ⑴抗滴森作用:黃柏煎劑,10%濃度與滴蟲液1 : 1混和培養’對陰道毛 滴蟲有抑制作用 (2)抗潰癌作用:黃柏提取物(去小檗域)皮下注射,灌胃或皮内注射,對 乙醇、’轉或間結輯發的大鼠胃潰射抑制作用。 ⑶鎮咳制:翻果實轉發具有触個,其鎮诚分主轉。 鲁 龍眼肉;為無患子科植物龍眼(Euphoria longan (LOUR.) STEUD.)之乾 燥假種皮。甘;溫。歸經:心;腎;肝;脾經。功能:補心、脾,養氣血,益 智。主治.驚悸’健忘’失眠,怔忡,婦人產後浮腫,脾虛泄萬。内服:煎 湯 ’ 10 〜15g。 38 201221135 2、龍眼肉現代藥理學研究依據:龍眼水浸齊,J(1:2)在試管内對奥杜盘氏 小芽麟菌有抑制作用。有鎮靜和健胃個。煎劑用紙片法對病疾 制作用。 、預聊 酸棗仁;為鼠李科植物酸棗(Zizyphus spinosa Hu)之乾燥種子。甘;平。 歸經:心;脾;肝;膽經。功能:養肝,寧心,安神,斂汗。主治:虛填不 眠,動博健忘’煩渴虛汗。内服:煎湯,6〜15g。 1、酸棗仁主要成分:酸棗仁驗(sanj〇jnjne) A、b'd、e、F、(31、 G2、la ' lb、K。 • 2、酸棗仁現代藥理學研究依據:本品脂肪油部分對小白鼠有延長己巴比妥 (Hezobarbital)催眠作用,對醋酸扭動反應有抑制作用,水可溶性部分有相同 作用。又甲醇可溶部份有鎮靜作用。 遠志;為遠志科植物遠志(Po丨yga丨a tenuif〇|ja w丨此)及同屬近緣植物 根皮H ;性微溫。歸經:心;肝;脾;腎經。功能: 安神益智,祛痰輯’通心竅,散·。主治:驚悸,健忘,夢遺,失眠及 思慮過度’癰疽’瘡腫及喉痺等症。内服:煎湯,3〜10g。 1、遠志主要成分··含_糖,彳,5錢山雜醇(彳,5她),生物驗,遠志 • 皂甘元(Pr〇Senegenin),美遠志喜細egenin),甲氧紐皮酸 (3,4’5-Trtmeth〇xy_cinnamicac丨d),夫喃桂皮酸息甘(〇_ 含遠志皂(Senega Saponin) A、B、C、D 等。 2、遠志現代藥理學研究依據·· ⑴鎮靜和抗驗··遠志根皮、未去木叫遠志全根和根部木心對巴比妥類 藥物均有協同作用。 ()抗滅舖侧.Ames趣發猶志的水雜提取麟黃麴徽菌素 B1 (AFB1)誘發的回變菌落數也有顯著的抑制效應,對丁湖菌株回變菌 落數有明顯抑制效應,但對TA100菌株無抑制麟。 ⑶對竹_ ••鼠之遠域崎_豚鼠m犬之未孕及已孕 39 201221135 子宮均有興奮作用,對孕狗在位子宮也有明顯的興奮作用。 檳榔;為棕橺科植物檳榔(Areca catechu LINN.)之成熟種子。味苦. 辛ί性溫。歸經:胃;大腸經。功能:宣滞破堅’殺蟲醒酒,消食行瘦,下 水除風,瀉胃中至高之氣,使之下行。主治:破積食滯,腹諸痛,瀉痢後 重,腳氣壅毒’水氣浮腫’痰癖’消癥結’殺蛔蟲。有助於腸内異常發酵及 炎症滲出物之排出。内服:煎湯,6〜I5g。 1、 檳榔主要成分:含生物鹼,檳榔驗(Arec〇line),檳榔次驗(Arecgjne),檳 榔副驗(Arecolidine),去甲基檳榔驗(Guacoline)。胺基酸,苯内氨酸 (Phenylalanine) ’ 脯氨酸(pr〇iine)。脂肪酸類;硬脂酸(stearjc add),癸酸 (Capricacid)。單寧類;兒茶精(catechin),原矢車菊(草字頭下 甘)(Procyanidin)B1、B2、B7,檳榔單寧(Arecatannin)A1、B1、A2、B2。 2、 檳榔現代藥理學研究依據: ⑴對中樞作用:本品檳榔鹼(arec〇|ine)於貓靜脈注射出現各種自律經症 狀,有刺激腦幹樣體,活化皮質腦波作用。 (2)對平滑肌作用:檳榔鹼與毛果芸香驗(pi|0Varpine)有相近作用,使腸管平 滑肌強力收縮’增加腸管緊張性及運動性,收縮曈孔平滑肌作用 ⑶對抗癌作用:從檳榔所得的聚紛化合物對艾氏腹水癌有顯著的抑制作 用,對Hela細胞有中度細胞毒作用。 ⑷對驅蟲_ :騎吸蟲、騎蟲、键、韻、域财鴨的體外抑 蟲作用, 防風;為繳形科植物防風(Saposhinkovia divaricata(TURCZ )SCHISCHK) 及近’緣植物之乾燥根“未辛;甘;性微溫。歸經:歸膀胱;肺;脾;肝經。 功能:解表,祐風,去濕,止痛。主治:治外感風寒找痛目眩,脊痛項強, 風寒濕痒,骨,節酸痛’四肢攣急,破傷風’祛風而不燥為風藥中潤藥。内服: 烈湯’ 5〜1〇g。 1 '防風主要成分:根含色_成分:防風色明醇(lede>b〇_|0|),4,-0- 201221135 葡萄糖基-5-0-甲基齒阿密醇(4’-〇glucosyl_5-0-methylvisamminol),3,-0_ 當歸酰基亥酚(3’-0-angeloyl-hamaudol),亥茅酚(hamaudol),3,-0-乙酰 基亥茅盼(3 i-O-acetyl-hamaudol);香豆精類成分:香柑内酯(bergapten), 補骨脂素(psora丨er〇,歐前胡内酯(jmperatorin);揮發油,辛醛(octanal), β-甜沒藥烯(β-bisabolene),壬醛(nonanal),7-辛烯各醇(y-octer^-ol), 已酸(hexanal)等。 2、防風現代藥理學研究依據··解熱、鎮痛作用:將家兔用三聯疫苗(百曰 咳、白喉、破傷風疫苗)製成動物致熱模型。關防風水煎液2g/kg,以安替 匹林和生理鹽水作對照。防風水煎液在1_2小時内解熱、鎮痛作用明顯。 烏藥;為樟科植物烏藥(Lindera stryChnifolia(SEB. et ZUCC.)F. VILLARS =Daphnidium strchnifolium SIEB_ etZUCC·)之乾燥根。辛;溫。 歸經:脾;胃、肝、腎、膀胱經。功能:行氣,止痛,溫腎,散寒。主治: 氣魏舰痛’宿食不消’反胃吐食’寒簡氣,小便頻數。内服:煎湯, 5 〜1〇g。 1、 烏藥主要成分:含釣樟内醋(Undera丨act〇ne),異釣棒内醋,異氧化釣棒(3) + take, the role of blood vessels: yellow alcohol extract 1g / kg Xingjin strongener 0.06g / kg intravenous injection, anesthetic dogs have significant antihypertensive effect. (4) Liver and spleen 'antioxidant: The injection of Astragalus membranaceus methanol extract has inhibitory effect on rat liver damage caused by isothiocyanate, which can inhibit the increase of serum bilirubin. Yellow miscellaneous extracts, jaundice 50 ’ gavage, favoring rabbits. The concentration of Rehmannia glutinin in vitro inhibits the lipid peroxidation of rat liver microsomes, and makes the scorpion of C. aeruginosa (MDA) content, Gardenia jasmjn〇ides ELUS angustifoha NAKAI and others. It is a mature dry fruit of a close relative. Bitter; cold. Returning to the heart: heart; liver 'lung' stomach 'two coke. Function: heat, phlegm; | fire, cool blood, can make the heart and lung heat flexion down, from the urine. Indications: upset sleepless jaundice, gonorrhea, thirst, red eyes, headache, vomiting blood 9 jfeftjia., wet heat yellow (infectious hepatitis, serum hepatitis). Oral: Jiantang, 5~1〇g. 1. The main components of the vibrator: Ifidoid glyceside, Jasminoidin, Geniposide, Gardenoside, Zhenziping-1-β-gentiobiose (Genipine>1-p~gentiobioside) Gardoside and so on. 2, the basis of modern pharmacology research of medlar: (1) analgesic effect: scorpion scorpion and its hydrolysate genipin on the intraperitoneal injection of acetic acid induced by mouse writhing 36 201221135 exercise inhibition. ί > : The influence of the county secrets and research on the activity of the enzymes in the pancreatic and pancreatic organs of rats. The vibrator and its extracts have obvious benefits, choleretic and hypotonic enzymes. ' 〇 () liver protection:] 21 丨 CR rats pre- (24 or station hours ago) given to the scorpion extract, can prevent fulminant hepatitis Coptis due to galactosamine bow, for the Ranunculaceae berberine (Coptis chjnensjs FRANCH), c teeta WAUJCH and the same roots to remove the dried rhizomes of the roots. Bitter; cold. Return to the classics: heart; liver; Function: away from fire, dampness, insecticide. Indications: When hot, typhoid, hot and upset, cancer full area, bacteria, heat, abdominal pain, tuberculosis, blood, diabetes, Zhou Ji, tsutsugamushi, whooping cough, because of swelling and pain 'mouth sores' 癍Acne poison, wet treatment, soup fire hurt. Oral: Jiantang, 15~3g. 1. The main component of κ 连: The roots of Rhizoma Coptidis contains Berberine and Palmatine. The rhizome of Rhizoma Coptidis contains berberine, Coptisine and deprotected base (Jateorrhizine) 〇2, berberine modern pharmacology research basis: (1) anti-inflammatory, anti-diarrhea effect: flavonol extract on chicken The fertilized egg has the effect of inhibiting the proliferation of granulation tissue. The 'small sputum hydrochloride sputum' has an anti-inflammatory effect on the croton oil capsule method and the cotton ball method. (2) Cardiovascular effect: Intravenous injection of small sputum 3_5mg/kg can reduce the gold pressure of anesthetized dogs. If the animals are treated with ergot in advance, the antihypertensive effect of the small sputum can be reversed. (3) Antipyretic effect: Intravenous injection of berberine injection has antipyretic effect on pyrogenic fever of rabbit leukocytes and decreases cAMP content in cerebrospinal fluid. (4) Antibacterial effect. Huanglian strongener 100/〇" Chen, the dish method showed 7 kinds of Gram-negative bacteria such as pathogenic bacteria, typhoid bacillus, paratyphoid bacillus, cholera bacterium, Escherichia coli and Proteus Staphylococcus, a-hemolytic streptococcus, B-hemolytic streptococcus, pneumococci, and bacilli-positive bacteria have strong antibacterial activity. (5) Antiviral effect: 50% concentration of berberine decoction 0.1ml/egg, chicken embryo test showed that influenza virus PR8 strain, sputum influenza virus 56~S8 strain, scorpion virus FM sputum strain, influenza B virus ^ 37 201221135 strain, internal test influenza virus 1233 strain have inhibition. Huanglian Jianqi j 25-100% concentration has an inhibitory effect on hepatitis B virus DNA. The skin tree (P chinensis SCHNEID·) and the same relative plants remove the dry bark of the outer surface. Bitter; cold ° to the kidney · kidney; bladder. Function·· Filling fire and detoxification, clearing heat and dampness, diarrhea and kidney fire (used for lower coke dampness and fever) also Xiaofu caused by steaming hot flashes, night sweats, nocturnal emission, etc.) Indications: Wet tropics Under the 'skunk yellow thick' damp heat jaundice, hot and humid bet, foot and knee swelling, pain, soft feet, hot and humid skin, wet poison 'wet treatment' bone steaming hot flashes, night sweats, nocturnal emission. Oral: Jiantang, 3~9g. 1. The main components of κ 柏: Berberine, a small amount of bioassay, Palmatine, Magnoflorine, Phellodenfrine, crystalline substance containing nitrogen-free ruthenium ; xanthone (〇bacun〇ne), and fat 'sterol compounds. Taiwan Astragalus contains about 3% of berberine. 2, Phellodendron modern pharmacology research basis: (1) anti-dripson effect: Huangbai decoction, 10% concentration and trichomoniasis 1:1 mixed culture 'inhibition of Trichomonas vaginalis (2) anti-cancer effect: Cork extraction The substance (to the small sputum field) was injected subcutaneously, intragastrically or intradermally, to inhibit the gastric ulceration of ethanol, 'transfer or interspersed rats'. (3) Antitussive system: Turning the fruit forward has a touch, and its town is divided into the main. Lulong's eye; a dry aril of Euphoria longan (LOUR.) STEUD. Gan; warm. Return to the classics: heart; kidney; liver; spleen. Function: fill the heart, spleen, raise qi and blood, benefit wisdom. Indications, convulsions, 'forgetfulness', insomnia, sputum, women's postpartum edema, spleen deficiencies. Oral: fried soup ‘10 ~15g. 38 201221135 2. Modern pharmacological research basis of longan meat: Longan water immersion, J (1:2) has inhibitory effect on A. sinensis in vitro. Have a calm and stomach. The decoction uses a paper method to treat the disease. Pre-talking Suanzaoren; dried seeds of Zizyphus spinosa Hu. Gan; Ping. Return to the classics: heart; spleen; liver; gallbladder. Function: Live the liver, Ningxin, soothe the nerves, sweat. Indications: imaginary filling, sleepless, forgetfulness, thirst, sweating. Oral: Jiantang, 6~15g. 1, the main components of jujube kernel: jujube kernel test (sanj〇jnjne) A, b'd, e, F, (31, G2, la ' lb, K. • 2, jujube kernel modern pharmacology research basis: this product fat The oil part has the effect of prolonging the hypnotic effect of Hezobarbital on the mice, inhibiting the writhing reaction of acetic acid, and the water-soluble part has the same effect. The soluble part of methanol has a sedative effect. (Po丨yga丨a tenuif〇|ja w丨) and the same relatives of the roots of the plant root H; sexually lukewarm. Return: heart; liver; spleen; kidney. Function: Anshen puzzle, 祛痰 》 Tongzhi 散, 散·. Indications: convulsions, forgetfulness, dreams, insomnia and excessive thinking '痈疽' sore and throat embolism. Oral: Jiantang, 3~10g. 1. The main ingredients of Yuanzhi···_糖,彳, 5 Qianshan (alcohol, 5 her), biological test, Yuanzhi • Soap ginseng (Pr〇Senegenin), Meiyuan Zhixi fine egenin), methoxynic acid (3,4'5-Trtmeth〇xy_cinnamicac丨d), cumin cinnamic acid (〇 _ containing Senega Saponin A, B, C, D, etc. 2. Yuanzhi modern pharmacology research basis · · (1) Sedation and anti-test ······························································································· The number of reverting colonies induced by Agrobacterium tumefaciens B1 (AFB1) also had a significant inhibitory effect, and it had a significant inhibitory effect on the number of colonies of Dinghu strains, but it did not inhibit the strain of TA100. (3) On bamboo _ •• rats The far-field squid _ guinea pig m dog's unpregnancy and pregnancy 39 201221135 The uterus has excitatory effects, and also has obvious excitatory effect on the uterus of the pregnant dog. Areca; for the mature of Areca catechu LINN. Seeds. Taste bitter. Scent tenderness. Return to the stomach: stomach; large intestine. Function: stagnation and breaking the 'killing and waking up the wine, digestion and thinning, getting rid of the wind, diarrhea in the stomach to the highest gas, make the next line. Indications: Broken food lag, abdominal pain, diarrhea and sputum, athlete's foot sputum poison 'water edema' 痰癖 'xiaozhi knot' killing mites. Helps abnormal intestinal fermentation and inflammatory exudate discharge. Oral: Jiantang, 6 ~I5g. 1. Main components of betel nut: alkaloids, Arec〇line, betel nut Arecgjne, Arecolidine, Guacoline, Amino Acid, Phenylalanine 'pr〇iine. Fatty Acids; Stearic Acid (stearjc) Add), Capric acid, tannins, catechin, procyanidin B1, B2, B7, Aretanann A1, B1, A2, B2 . 2, Betel nut modern pharmacology research basis: (1) the central role: the product arecaline (arec〇 | in) intravenous injection of cats appear a variety of autonomic symptoms, stimulate the brain stem-like body, activate cortical brain waves. (2) Effect on smooth muscle: arecoline and musk scent test (pi|0Varpine) have similar effects, making the intestinal smooth muscle strong contraction 'increased intestinal tension and motility, shrinking pupillary smooth muscle effect (3) anti-cancer effect: from areca nut The obtained poly compound has a significant inhibitory effect on Ehrlich ascites carcinoma and moderate cytotoxicity on Hela cells. (4) Deworming _: Insect worm effect of riding trematode, worm, key, rhyme, and sylvestris, windproof; Saphinkovia divaricata (TURCZ) SCHISCHK and dry roots of near-edge plants "Not sin; Gan; sexually lukewarm. Return to the classics: return to the bladder; lung; spleen; liver. Function: solution, wind, dehumidification, pain relief. Indications: treatment of external sensation, cold, dizziness, strong spinal pain, Wind, cold and itchy, bone, joint pain, 'four limbs rush, tetanus' hurricane and not dry for the drug in the wind medicine. Oral: Lie Tang '5 ~ 1 〇 g. 1 'wind main components: root color _ ingredients: Windproof color alcohol (lede>b〇_|0|), 4,-0- 201221135 Glucosyl-5-0-methyldentamidol (4'-〇glucosyl_5-0-methylvisamminol), 3,-0_ Angelica sinensis (3'-0-angeloyl-hamaudol), hamaudol, 3,-0-acetyl chlorpyrifos (3 iO-acetyl-hamaudol); coumarin essence: citrus Ester (bergapten), psoralen (psora丨er〇, jmperatorin; volatile oil, octanal, β-bisabolene, nonanal, 7-octene alcohol (y-octer^-ol), acid (hexanal), etc. 2. Modern research on wind-proof pharmacology ··Antipyretic and analgesic effects: Three-way vaccine for rabbits (hundredness cough, diphtheria, Tetanus vaccine was made into animal heating model. Guanfu Fengshui decoction 2g/kg, with antipyrine and normal saline as control. Anti-fengshu decoction has obvious antipyretic effect and analgesic effect within 1_2 hours. Dry root of Linda stry Chnifolia (SEB. et ZUCC.) F. VILLARS = Daphnidium strchnifolium SIEB_ etZUCC·). Xin; Wen. Returning: spleen; stomach, liver, kidney, bladder. Function: Qi, pain relief Insects, warm kidney, dispelling cold. Indications: Qi Wei Ship pain 'food can not eliminate 'anti-stomach vomiting' cold and qi, frequent urination. Oral: Jiantang, 5 ~ 1〇g. 1, the main components of black medicinal herbs: including fishing rod Inside vinegar (Undera丨act〇ne), vinegar in different fishing rods, iso-oxidized fishing rod

Jr(lsolmderoxide) ^ ^#>j#s|(Linderene) > i^#i^s|(Neolinderalactone) > 異已夫喃(丨sogermafurene) ’新木薑子峨|_3υ「〇|^ηβ),等倍半帖類 (sesquiterpenes)。 2、 烏藥現代藥理學研究依據: ⑴揮發油的興奮作用:内服時’有興奮大腦皮質的作用,並有促進呼吸, 興奮心肌,加速血循環’升高血壓及發㈣作㈣料贿局部血管擴張, 血循環加速,緩和肌肉痙攣性疼痛。 (2)對消化道的影響:烏藥對胃腸平滑肌有增加消化液的分泌。 ⑶止血作用:體外實驗證明,烏藥乾粉能明顯縮短家兔血製卿匕時間, 促進血凝及陕的止血铜。魏腦可發汗、興奮、_、驅蟲等。 枳殼;為芸香科植物松橘(Poncirus耐昧))、酸_邮 201221135 aurantium LINN·)或香圓(C. wilsonii TANAKA)及同屬近緣植物之未成熟果 實。苦;酸;性微寒。歸經:肺;脾;肝;胃;大腸經。功能:破滯氣,寬 腸胃,祛痰。主治:胸膈痰滞食積,嘔逆反胃,霍亂瀉痢,傷寒呃嗓,直腸 脫垂。内服:煎湯,3〜9g。 Ί、枳殼主要成分:香圓未成熟果實含燈皮甘(Hesperidin),新橙皮甘 (Neohesperidin) ’酸橙皮油醇(Auraptenol)。本品果實尚含糊蘿萄素 (β-Carotene ’ ^Carotene),橙色素(Citraurin)等。 2、枳殼現代藥理學研究依據: (1) 對氣管平滑肌的作用:辛弗林有較強的擴張氣管和支氣管的作用。麻醉 薄田靜脈注射可完全對抗組胺所引起的支氣管收縮,對脉鼠離體氣管亦有同樣 的作用。 (2) 抗血球凝集作用:大鼠服用枳殼中成分川陳皮素,有抑制血小板的凝集 作用’對大鼠有明顯的抗血栓形成作用。 (3) 抗癌作用:川陳皮素對鼻咽癌KB細胞的半數有效量為3_28|jg/m丨,體 内對小鼠Lewis肺癌和瓦克癌瘤256亦有效。 (4) 對子宮平滑肌的作用:枳實煎劑對未孕及已孕的兔離體子宮、在位子宮 和未孕兔的子宮疼均有明顯的興奮作用,能使子宮收縮節律增加。但對小鼠 離體子宮不論已孕或未孕部分起抑制作用。 (5) 胃腸平滑肌的作肖:积實煎劑對小鼠離體腸管部分呈抑制作用,而兔離 體腸管則铸表現抑制。能使胃腸運動收縮轉增加。 白芨;為蘭科植物白芨(Bletilla striata (THUNB.) REICHB f.) 之乾燥肉質塊莖m;寒。歸經:肺;胃經。功能:敛肺,止 血’生肌消腫。主治:肺胃出血’站血,外傷手術.出血,癞疽腫毒潰 蹲’湯火灼傷,手足皸裂。内服:煎湯,3〜1〇g。 、白芨主要成分:根含白芨葡萄甘露聚糖(_丨丨a glucomannan)等黏液 多醣。 / 42 201221135 2、白笈現代藥理學研究依據: (1) 止血作用:白及根磨成細粉或白及煎煮後所得膠狀液摻入澱粉烘乾 研末,於狗肝行止血試驗皆於6分鐘内達到滿意的止血效果。 (2) 抗癌及防癌作用··白及粘液質部分(主要為多糖成分)5〇mg/只腹 腔注射’對大鼠瓦克癌(W256)小鼠子宮頸癌(υΐ4)、小鼠艾氏腹水 癌實體型均有抑制作用,對小鼠肝癌、肉瘤18〇也有抑制作用。 本發明製備與綱:本發·療女性軸赫的巾草藥萃取濃縮組合 # 物,製備方式與產品劑型,依地區與使用者使用習慣不同,可採用飲片煎 劑或濃縮煎劑方式服用’及使歸學濃射_粒劑、濃縮錠劑、濃 縮膠囊劑型等各劑型,製備依據如下: -般情況下飲片,¾劑或稱濃縮煎劑,為—般家庭婦女在家,無繁雜 事物狀況下’可贱片煎鑛理或委請縣代銳縮煎_真空包包 裝’每曰用藥量依婦女病症需要調配,為目前時下很方便的方法。 採用科學中藥濃縮包括萃取、分離、濃縮、乾燥等工程所取得之中 f顆粒劑情況下,濃縮顆粒劑型的溶出速率及生物利用率比較好;劑 • 量準媒;標誌、性成分含量差異較小;品質、質量穩定;經再加工成片 劑、錠劑或縣等劑型;攜帶、運輸、較方便;成品便於攜帶、 貯存期長。機械化生產’產量大,成本低,衛生標準容易達到。Jr(lsolmderoxide) ^ ^#>j#s|(Linderene) >i^#i^s|(Neolinderalactone)> 已夫夫(丨sogermafurene) '新木姜子峨|_3υ"〇|^ Ηβ), sesquiterpenes. 2. Modern pharmacological research basis of black medicinal herbs: (1) Excitatory effects of volatile oil: When taking oral action, it has the effect of exciting the cerebral cortex, and promotes breathing, excites the myocardium, and accelerates blood circulation. Hypertension and hair (four) for (four) brittle local vasodilation, accelerated blood circulation, ease muscle spasm pain. (2) the impact on the digestive tract: black medicinal smooth muscle has increased secretion of digestive juice. (3) hemostasis: in vitro test The dried powder of black medicinal herbs can significantly shorten the time of rabbit blood stasis, promote blood coagulation and stop bleeding copper in Shaanxi. Wei brain can sweat, excite, _, deworming, etc. 枳 ;; for the 芸 植物 plant pine orange (Poncirus 昧)), acid _ mail 201221135 aurantium LINN ·) or fragrant round (C. wilsonii TANAKA) and immature fruits of the same genus. bitter; acid; sexually cold. return: lung; spleen; liver; Large intestine. Function: broken gas, wide stomach, phlegm. Indications:膈痰 食 食 , 呕 呕 呕 呕 呕 呕 呕 呕 呕 呕 呕 食 食 呕 呕 呕 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 Neohesperidin 'Auraptenol'. The fruit of this product still contains β-Carotene ' ^Carotene, Citraurin, etc. 2. Basis of modern pharmacology research of clam shell : (1) Effect on tracheal smooth muscle: Synephrine has a strong effect of dilating the trachea and bronchus. Intravenous injection of thin field can completely prevent bronchoconstriction caused by histamine, and has the same effect on isolated tracheal trachea. (2) Anti-blood agglutination: Rats taking chopped cane in the clam shell, which inhibits the agglutination of platelets, have obvious antithrombotic effects on rats. (3) Anticancer effect: Chuan Chenpisu on the nose The half effective amount of pharyngeal carcinoma KB cells is 3_28|jg/m丨, which is also effective in mouse Lewis lung cancer and Wacker cancer 256. (4) Effect on uterine smooth muscle: 枳 煎 decoction on non-pregnant and already Pregnant rabbit isolated uterus, in situ uterus and unborn rabbit Uterine pain has obvious excitatory effects, which can increase the uterine contraction rhythm. However, it inhibits the isolated uterus of the mouse regardless of the pregnant or non-pregnant part. (5) The function of gastrointestinal smooth muscle: the accumulation of decoction on mice The intestine part of the intestine is inhibited, while the isolated intestine of the rabbit is inhibited by casting, which can increase the contraction of gastrointestinal motility. White peony; dry succulent tubers of the genus Bletilla striata (THUNB.) REICHB f. cold. Return to the classics: the lungs; stomach. Function: Converging the lungs, stopping the blood's swelling of the muscles. Indications: lung and stomach bleeding 'station blood, trauma surgery. Bleeding, swollen poisonous ulcers 蹲' soup fire burns, hands and feet splitting. Oral: Jiantang, 3~1〇g. The main components of Radix Paeoniae Alba: mucus polysaccharides such as 丨丨丨丨 glucomannan. / 42 201221135 2, the basis of modern pharmacology research of white peony: (1) Hemostasis: white and root grinding into fine powder or white and the gelatinized liquid obtained after boiling is mixed with starch to dry the powder, and the hemostasis test in dog liver All achieved a satisfactory hemostasis effect within 6 minutes. (2) Anticancer and anticancer effects · White and mucous fraction (mainly polysaccharides) 5〇mg/only intraperitoneal injection of 'Wach's cancer in WACKER mice (υΐ4), mouse Ai The solid type of ascites cancer has an inhibitory effect, and it also inhibits liver cancer and sarcoma in mice. The preparation and the outline of the invention: the herb extract extraction concentration combination of the hair and the treatment of the female axis, the preparation method and the product dosage form, can be taken by using the decoction of the decoction or the concentrated decoction according to the different usage habits of the region and the user' The dosage forms of concentrating granules, granules, concentrated tablets, concentrated capsules, etc. are prepared as follows: - In general, the pieces are taken, 3⁄4 or concentrated decoction, for the family woman at home, without complicated things 'Can be used for frying or frying or arranging the county for sharp shrinking _ vacuum package's dosage per medicinal dosage according to the needs of women, it is a convenient method at present. In the case of the use of scientific Chinese medicine concentration, including extraction, separation, concentration, drying, etc., the dissolution rate and bioavailability of the concentrated granules are better; the agent • the amount of media; the difference between the markers and the content of the components Small; quality, quality and stability; reprocessed into tablets, tablets or county and other dosage forms; portable, transport, more convenient; finished products are easy to carry, long storage period. Mechanized production 'large output, low cost, easy to achieve health standards.

製備技術··本發明治療女性經痛疾病的中草藥萃取濃縮 成型工藝技術方式: I 粘合劑的參考:如表1;齡劑在選擇上應從顆粒的可行性、光潔 度、崩解度等多方面進行。結果:3〇%食用酒精為合劑制粒易、易 乾餘,制得的顆粒較好,如須加域片劑、錠戦膠囊劑型進行加工Preparation Technology····································································································· . RESULTS: 3〇% edible alcohol is easy to granulate and easy to dry. The obtained granules are better, such as the addition of domain tablets and ingot capsules.

S 43 201221135 表1填充劑S 43 201221135 Table 1 filler

枯合劑 _易乾燥、制粒易、奵 乾燥、制粒不易、崩解差Y来彳 一___#性太大、制潔度好 30%食用酒精 8%澱粉漿 水 潤滑劑的_:魏龍為以織無雜細 溶于水、醇,’微溶於熱醇及苯,性f穩定,不自身聚合。具有: 滑、抗點、助流作用,主要職片劑關_,但由於其疏水性可二 遲藥物的溶出,因此要求使用量盡可能低,—般使用量為Q 2视〜2 〇 %。本品忌與鹼性、酸性物質以及鐵鹽、強氧化劑配伍。 選擇潤滑_試驗結果見表2,伽硬職_可_要求, 片重或膠囊的0.8%就可以了。 ’’、、 表2潤滑劑的參考 潤滑劑 硬脂酸 鎂用量 微粉梦 膠用量 製粉或膠囊 崩解時 硬脂酸鎂 1.2% - 硬度與光潔度好,較 不粘沖,無裂片 P艮 17min 硬脂酸鎂 0.8% - 硬度與光潔度好,較 不粘沖,無裂片 18min 硬脂酸鎂+微粉矽膠 0.8% 0.8% 硬度與光潔度好,無 粘沖,無裂片_ 16min GMP生產:本發明治療女性經痛疾病的中草藥萃取濃縮組合物,產品 生產工藝的實施’各個加玉炮製卿均配有符合GMp規定的設備與設 施之藥廠’從祕基源·製完成細試製生產,全依糊家藥典規 定著手,試製生產情況分析,產品工藝解,可操作性強,生產過程 便於控制’產品質量穩定可靠’因此,產品的工藝設計是安全可行的, 201221135 合理的,科學的,符合企業GMP質量標準要求。 【實施方式】 本發明提供治療女性經痛疾病的中草藥萃取濃缩組合物,產品生產工 藝的實施,各個加工炮製環節均配有符合GMP規定的設備與設施之藥 廠’從原料基源到炮製完成採購試製生產,全依照國家藥典規定著手, 可供一般家庭婦女慣用之飲片煎劑或濃縮煎劑製備外,製備方式更採用科學 中藥濃縮包括萃取、分離、濃縮、賴等工赖取得之帽顆輔,可經再 加工成片劑、錠劑或膠囊等劑型,成品便於使用者攜帶,服用較方便,安全 衛生,貯存期長。 本發明治療女性_疾病齡草解取難組合物,配合病理機轉研發 目的在解決女性平常或生理期間,因外因六淫(風、暑、濕、燥、寒、火) 滯留於體内,導贿胃之氣無法運化制蒙失調,影響子宮收縮與自律神經 中樞受到干擾,«I引壯性婦科、子宮或M氣滯鱗魏失調,進而引 起經痛症候群疾病;其經痛症候群疾病有:乳房服痛、頭痛、目眩”區吐、 勝廋背痛、腹痛、冒冷汗、手腳發冷、食您失常、月經提前、月觀後、月 經量少、域、閉經、情緒障礙、鬱鬱寡歡、脾氣祕、睡眠障礙、白帶、 子宮肌瘤、巧克力囊腫、子宮内膜異位、.月經時量多、質淡、血崩、灰漏、 滴漏、出血、腫瘤、子宮腺瘤、水腫等症狀造成生活的影響。 請配合參閱如圖1臨床病症分佈圖,本發明治療女性經痛疾病的中草藥 萃取濃縮組合物’在臨床52位有效實施例中如圖i,揭示生理期經痛症候 群疾病臨床症狀分部比率情形;另依女性生理期經痛症候群病理機轉不同, 病症程度分成四期及病症人數比率: (1) 第一期一般型經痛,人婁i:比率佔7〇%。 (2) .第二期非出血性肌瘤型經痛,人數比率佔15%。 45 201221135 (3) .第三期出血伽瘤型經痛’人數比率佔·。 (4) .第四期腫瘤經痛,人數比 前臨庆上子玄_ ,羊佔以°其中女性生理期一般子宮腫瘤,在目 職’尊重絲_生命安全為前提.以上 太路a I S腫瘤切除治療,然而臨床實施便難舉例說明其治療效果。 日治療女性經痛疾病的中草藥萃取濃縮組合物,配合藥理' 佐、細域轉鱗顧断職麵賴料如: ' 、則加強祛除外邪,祛除滞留於脾胃、子宮體内的外邪, ,科與荷爾蒙失調、子宮或卵巢氣滞血瘀功能失調,所引發痛經、 血塊、月經不規則、職、、子宮_瓣不全肌瘤增生問題。. 臣樂-賴柳加維n料刪纖鱗胃之氣無原 :痛、頭痛、目眩 '想吐、手腳發冷、失眠、鬱鬱紐、情緒低嶋等問 佐藥-用藥原則:加強溫子宮、祛寒氣、活血麟,幫助子宮 子宮内膜能完整概,減緩清_瘤触_ 經血塊、月經不規則'腰痛、頭痛等問題。 产使樂-用藥原則:將活血化癖的主藥引入子宮或脾胃效率,加強祛除寒 氧、溫子宮’減除痛經、錢為氣滞血齋造成、月經不規則、勝痛、頭痛等 問題。 請配合參酬2與配合參閱實施例表3、表4 ;本發日月治療女性經痛疾 病的中草藥萃取濃縮組合物之組合物配方,其配方組合物依病理與藥理機轉 與安全劑量範圍使用酬配伍’其臨床賴效果,請配合參晒2與配合參 閱實施例表3、表4 ’為揭示依女性經痛症候群分四期病理機轉及病症實施 例人數統計表與運用本發日月組合物配方之治療成效比率;其治療姐比率越 高,證明本發明組合物配方之療效卓越成果。 請配合參閱表4及另請參閱圖3,為本發明治療女性經痛疾病的中草藥 46 201221135 卒取濃縮組合物之第-組組合物配方,實施臨床用藥統計表由統計表中得 知’第-組組合物配方,可于短時間内快速有效改善治療第一期一般型女性 生理期經痛症候群問題;在圖3中第一組中草藥萃取濃縮組合物配方經痛症 候群症狀治療比率統計表,證明可超越或取代西藥普拿疼的所有功效,更不 會有副作關題的產生,其未來市場雜更是另人宏觀。 本發日月治療女性經痛疾病的中草藥萃取濃縮組合物之第一組組合物配 方’其配方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,專供治 療女性經痛疾病第-期—般型經痛組合物,其中萃取濃縮中草藥中每扣公 • 克中包含有:當歸3〜129、桃仁3〜12g、川琴2〜10g、延胡索2〜10 桂枝2〜仰、牡丹皮2〜9g、的2〜响、蒲黃2,、牛膝2,、赤 与饧〜89、五靈脂1.4〜89、紅花12〜69、茯茶1,、大腹皮1〜的、 白足1〜6g、紫蘇1〜6g、藿香卜69、生薑%、肉桂〇5〜4 5g、沒藥 〇·5〜4.5g、桔梗〇.5〜4.5g、白求〇 5〜4的、厚朴〇 5〜4匈 '灸甘草⑽ 〜3g等組成之組合物’為本發明治療女性經痛疾病的中草藥萃取濃縮組合 物之第一組組合物配方。 請配合參閱表4及另請參閱圖4,為本發明治療女性經痛疾病的中草藥 • 萃取濃縮組合物之第二組組合物配方,實施臨床用藥統計表,由統計表中得 知,第二組組合物配方,可于短時間内快速有效改善治療第二期非出血性肌 瘤型女性生理鑛細_題;細4 ”二_草料取濃驗合物配 方經痛症候群症狀治療比率統計表,證明可超越或取代西藥普拿疼的所有功 效,更不會有副作關題的產生,其未來市場價值更是另人宏觀。 本發明治療女性經痛疾病的中草藥萃取濃縮組合物之第二組組合物配 方,其配方組合物依病理與藥理機轉與安全継範圍使用原則配伍,專供治 療女性經痛疾病第二期非出血性肌瘤型經痛組合物,其中萃取濃縮中草藥中 每10公克中包含有:當歸3〜12g、桃仁3〜12g、川琴2〜i〇g、延胡索2 〜1〇g、桂枝2,、牡丹皮2〜9g、的2〜1〇g、蒲黃2,、牛膝2 47 201221135 e ^ 14.8g. ^, 2^g ^ ^ ^ ^ 皮Mg、自止彳〜69、如〜&、如〜6g ::沒藥。——^^ 厚朴0.5〜4.5g、半夏麴Q_5〜4 5g、炙甘草G 3〜3g 〇 ==π組成之組合物,為本發,療女性經= t草樂卒取濃縮組合物之第二組組合物配方。 ^合^閱表4及另請參閱圖5,為本發明治療女性經痛疾病的中草藥 卒取濃縮組口物之第二組組合物配方,實施臨床用藥統計表,由統計表中得 知’第三組組合物配方,可于短時間内快速有效改善治療第三期出血性肌瘤 型女性生理期經痛症候群問題;在圖5中第三組中草藥萃取濃縮組合物配方 經痛症候群症紐雜率断表,刻可超越錄麵轉拿疼的所有功 效,更不會有爾關題的產生,其絲市場舰更是$人宏觀。Dry mixture _ easy to dry, easy to granulate, dry, difficult to granulate, poor disintegration Y to 彳 ___# too much, good cleanliness 30% edible alcohol 8% starch slurry water lubricant _: Wei The dragon is woven without impurities and is soluble in water, alcohol, and is slightly soluble in hot alcohol and benzene. The property is stable and does not polymerize itself. Has: slip, anti-point, help flow, the main job is off _, but because of its hydrophobicity, the dissolution of the drug can be delayed, so the required amount is as low as possible, the general use amount is Q 2 ~2 〇% . This product should not be compatible with alkaline, acidic substances, iron salts and strong oxidants. Select Lubrication _ test results are shown in Table 2, Jia hard job _ can _ request, tablet weight or 0.8% of the capsule can be. '',, Table 2, Lubricant Reference Lubricant, Magnesium Stearate, Micro Powder, Dream Gel, Powder, or Capsule Disintegration, 1.2% Magnesium Stearate - Hardness and Finish, Less Sticky, No Cracks P艮17min Hard Magnesium oleate 0.8% - Hardness and smoothness, less stickiness, no cleavage 18min Magnesium stearate + micronized eucalyptus 0.8% 0.8% Good hardness and finish, no sticking, no cleavage _ 16min GMP production: The present invention treats females Chinese herbal medicine extract concentrate composition for menstrual diseases, the implementation of the production process of the product. Each of the jade cannons are equipped with a GMp-compliant equipment and facilities. From the secret source and system, the fine trial production is completed. Provisions, trial production analysis, product process solution, operability, production process is easy to control 'product quality is stable and reliable' Therefore, the process design of the product is safe and feasible, 201221135 reasonable, scientific, in line with corporate GMP quality standards Claim. [Embodiment] The present invention provides a Chinese herbal medicine extract concentrated composition for treating women's menstrual pain diseases, and the production process of the product is carried out, and each processing and processing link is equipped with a pharmacy that meets the requirements of GMP regulations, from the raw material source to the finished product. Purchasing trial production, all in accordance with the provisions of the National Pharmacopoeia, can be used for the preparation of decoctions or concentrated decoctions commonly used by women in general households. The preparation method is more concentrated with scientific Chinese medicine, including extraction, separation, concentration, and Lai. Supplementary, it can be reprocessed into tablets, tablets or capsules. The finished product is easy for users to carry, easy to take, safe and hygienic, and has a long storage period. The invention treats a female _ disease-aged grass to solve the difficult composition, and cooperates with the pathological machine to develop the purpose of solving the normal or physiological period of the female, because the external cause of the six kinky (wind, heat, wet, dry, cold, fire) is retained in the body, The blood of the bribe can't be transported, and the uterus contraction and the autonomic nerve center are disturbed. «I attract gynecological, uterus or M qi stagnation, and then cause dysmenorrhea syndrome. The pain syndrome diseases are: Breast pain, headache, dizziness, vomiting, sputum, back pain, abdominal pain, cold sweat, cold hands and feet, eating disorders, early menstruation, after the moon, less menstruation, domain, amenorrhea, mood disorders, depression, Spleen secret, sleep disorders, leucorrhea, uterine fibroids, chocolate cysts, endometriosis, menstrual volume, light, blood collapse, gray leak, drip, bleeding, tumor, uterine adenoma, edema and other symptoms cause life Please refer to the distribution of the clinical symptoms of the present invention as shown in Figure 1. The Chinese herbal medicine extract concentrate composition for treating female menstrual pain disease in the present invention is shown in Figure The clinical symptom segmentation rate of menstrual pain syndrome disease; according to the female pathogenesis of menstrual pain syndrome, the degree of disease is divided into four phases and the number of patients: (1) The first phase of general menstrual pain, human 娄i: ratio accounted for 7 2%. (2). The second phase of non-hemorrhagic myoma-type menstrual pain, the proportion of the number of people accounted for 15%. 45 201221135 (3). The third phase of gamma-type dysmenorrhea menstrual pain rate of people accounted for. (4). Fourth The stage of tumor pain, the number of people than the previous Linqing Shangzi Xuan _, the sheep accounted for ° in the female physiological period of general uterine tumors, in the premise of 'respect for silk _ life safety. Above the road a IS tumor resection treatment, but clinical implementation It is difficult to exemplify the therapeutic effect. The Chinese herbal medicine extract concentrate composition for treating women with menstrual pain, with the pharmacology of 'Zuo, fine-grained scales to take care of the face, such as: ', then strengthen the sputum and eliminate evil, remove the spleen and stomach, Exogenous evils in the uterus, family and hormone disorders, uterine or ovarian qi stagnation and blood stasis dysfunction, caused by dysmenorrhea, blood clots, irregular menstruation, occupation, uterine insufficiency of fibroids. Liu Jiawei n material There is no originality in the stomach of the scales: pain, headache, dizziness, vomiting, cold hands and feet, insomnia, depression, depression, etc. Adjudication - medication principle: strengthen the warm uterus, chills, blood lining, help the uterus uterus The endometrium can be completely intact, slowing down the _ _ tumor touch _ menstrual blood clots, irregular menstruation 'back pain, headache and other issues. Produce music - medication principle: the main drug for promoting blood circulation and phlegm into the uterus or spleen and stomach efficiency, strengthen the elimination of cold oxygen, Warm uterus' loss of dysmenorrhea, money for qi stagnation of blood, caused by irregular menstruation, pain, headache, etc. Please refer to Table 3 and Table 4 for the participation and participation in the treatment of women's menstrual diseases. The composition of the composition of the Chinese herbal medicine extracting concentrated composition, the formulation composition according to the pathology and the pharmacological machine is transferred to the safe dosage range, and the use of the compound composition is used for the clinical effect, please cooperate with the sun-blown 2 and cooperate with the reference to the examples Table 3 and Table 4' In order to reveal the ratio of the number of patients in the four-stage pathological changes and symptoms according to the female menstrual pain syndrome and the therapeutic effect ratio of the formula of the present day and the month; the higher the ratio of the treatment sisters, the composition of the present invention is proved The superior efficacy results. Please refer to Table 4 and see also FIG. 3, which is a formula of the first group composition of the Chinese herbal medicine 46 201221135 Stroke Concentrated Composition for treating menstrual pain in women of the present invention, and the statistical table of the clinical medication is known from the statistical table. The composition formula of the group can quickly and effectively improve the treatment of the first period of general women's menstrual period pain syndrome in a short period of time; in Figure 3, the first group of Chinese herbal medicine extract concentrate composition formula through the pain symptom group treatment ratio statistical table, proves to be beyond Or replace all the effects of western medicine Pu Na pain, and there will be no secondary work problems, and its future market miscellaneous is another macro. The first group composition formula of the Chinese herbal medicine extract concentrated composition for treating women's menstrual pain in the present day and month is formulated according to the pathology and pharmacological machine and the safe dosage range, and is specially designed for treating women's menstrual diseases. The general type of menstrual pain composition, wherein each extract of concentrated Chinese herbal medicine contains: Angelica 3~129, peach kernel 3~12g, Chuanqin 2~10g, Yanhusuo 2~10 Guizhi 2~ Yang, Mudanpi 2~ 9g, 2~ ring, Puhuang 2, Achyranthes 2, Red and 饧~89, Wulingzhi 1.4~89, safflower 12~69, 茯茶1, 大腹皮1~, 白足1~ 6g, perilla 1~6g, musk 48, ginger%, cinnamon 〇5~4 5g, myrrh 〇·5~4.5g, platycodon grandiflorum.5~4.5g, white 〇5~4, magnolia 〇5~4 Hungarian moxibustion licorice (10) ~3g composition of the composition 'is the first group composition formulation of the Chinese herbal medicine extract concentrated composition for treating female menstrual pain disease. Please refer to Table 4 and please refer to FIG. 4 , which is a second group composition formula of a Chinese herbal medicine extract concentration composition for treating female menstrual pain diseases according to the present invention, and a clinical drug statistical table is implemented, which is known from the statistical table, the second group The composition formula can quickly and effectively improve the treatment of the second stage non-hemorrhagic myoma type female physiology minerals in a short period of time; fine 4" two_grass thickening complex formula through pain symptom syndrome treatment rate statistical table, proof It can surpass or replace all the effects of Western medicine, and it will not have the problem of side effects. Its future market value is even more macroscopic. The second group of Chinese herbal extract concentrate composition for treating women with menstrual pain The formula is formulated according to the pathology and the pharmacological machine and the safe use range, and is specially designed for treating the second-stage non-hemorrhagic myoma-type menstrual pain composition of female menstrual pain diseases, wherein each 10 g of the extract concentrated Chinese herbal medicine contains There are: Angelica 3~12g, peach kernel 3~12g, Chuanqin 2~i〇g, Yanhusuo 2~1〇g, Guizhi 2, Mudanpi 2~9g, 2~1〇g, Puhuang 2, Achyranthes 2 2 2 01221135 e ^ 14.8g. ^, 2^g ^ ^ ^ ^ Skin Mg, self-stop 彳~69, such as ~&, such as ~6g::Myrrh. -^^ Magnolia 0.5~4.5g, Pinellia麴Q_5~4 5g, licorice G 3~3g 〇==π composition, the second group composition formula of the present invention, the therapeutic group of women. 4 and FIG. 5 is a second group composition formula of a Chinese herbal medicine stroke concentration group for treating menstrual pain in women according to the present invention, and a clinical drug statistical table is implemented, and the third group composition formula is known from the statistical table. In a short period of time, it can quickly and effectively improve the treatment of menstrual pain syndrome in women with stage III hemorrhagic myoma. In Figure 5, the third group of Chinese herbal medicine extract concentrate composition formula is painful and symptomatic. All the effects of recording the face and taking the pain, there will be no generation of the title, the silk market ship is more than a human macro.

本發明治療女性經痛疾病的中草藥萃取濃縮組合物之 方,其配方組合物依病理與藥理機轉與安全劑量細使用原則配伍,^供治 療女性經痛疾病第三期出血十恤瘤型經痛组合物,其中萃取濃縮中草藥中每 10公克中包含有:當歸3〜12g、熟地黃1〜3〇g、生地黃㈠如、白苟2 〜1〇9、川_ 2〜1〇g、黃茶!〜9g、振子)〜1Qg '黃連〇 3〜3g、黃柏〇 3 〜9g、人參1〜15g、龍眼肉〇_5〜15g、炙甘草〇 3〜12g、白求〇 5〜i5g、 茯苓0.5〜15g、酸棗仁〇.5〜15g、遠志α5〜15g、生薑〇 5〜1〇g、大襄 0_5〜12g、白笈〇.2〜1〇g等組成之組合物,為本發明治療女性經痛疾病的 中草藥萃取濃縮組合物之第三組組合物配方。 請配合參閱表4及另請參閱圖6,為本發明治療女性經痛疾病的中草藥 萃取濃縮組合物之第四組組合物配方,實施臨床用藥統計表,由统計表中得 知,第四組組合物配方’可于短時間内快速有效改善治療第四期腫瘤型女性 生理期經痛症候群問題;在圖6中第四組中草藥萃取濃縮組合物配方經痛症 候群症狀治療比率統計表’證明可超越或取代西藥普拿疼的所有功效,更不 48 201221135 會有副作關題的赴’其絲市場雛更是另人宏觀。 本發明治療姐賴疾病种草鮮取舰組合物之細她合物配 方,其配方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,專供治 療女性域疾鮮四細麵經雜合物,其巾萃取濃斜草藥巾每1〇公 克中包含有:當歸3〜12g、桃仁3〜12g、川号2〜1〇g、延胡索2〜i〇g、 桂枝2〜10g、牡丹皮2〜9g、的2〜1〇g、蒲黃2〜9g、牛膝2,、赤 苟15〜8g'五靈脂14〜8g、紅花12,、白施,、紫_〜响、 肉桂2〜5g、沒藥〇.5〜10g、祐梗〇 5〜1〇g、厚朴〇 3〜响甘草的〜 12g、乾薑αΐ〜1〇9、人參α5〜15g、檳榔〇 3〜15g、黃耆◦ 5〜峋防 風W〜1Qg、木香α3〜9g、烏藥σ3〜·积殼〇 3,、小_ 〇 ]〜 3g等組成之組合物,為本發·療女性_疾病的中草轉取濃縮組合物 之第四組組合物配方。 口 臨床實施例如下說明: 實施例1 受試者:蔡小姐’ 1967出生,42歲,身高165cm,體重55kgThe invention provides a Chinese herbal medicine extract concentrated composition for treating menstrual pain diseases of a female, and the formula composition is compatible with the pathological and pharmacological machine and the safe dosage fine use principle, and is used for treating the third-stage hemorrhage of the female menstrual pain disease. Among them, each 10 grams of extracted concentrated Chinese herbal medicine contains: Angelica 3~12g, Rehmannia glutinosa 1~3〇g, Rehmannia glutinosa (1), Baiji 2~1〇9, Chuan_2~1〇g, yellow tea! ~9g, vibrator)~1Qg 'Huanglian〇3~3g, Phellodendron 3~9g, ginseng 1~15g, longan meat 〇5~15g, 炙甘草〇3~12g, 白求〇5~i5g, 茯苓0.5~ 15g, Suanzaoren 〇.5~15g, Polygala α5~15g, Ginger 〇5~1〇g, Big 襄0_5~12g, Baiji.2~1〇g, etc., is a therapeutic female for the present invention A third set of composition formulations of a concentrated extract of Chinese herbal medicine extracts for menstrual diseases. Please refer to Table 4 and please refer to FIG. 6 , which is a fourth group composition formula of a Chinese herbal medicine extract concentrated composition for treating female menstrual pain diseases according to the present invention, and a clinical drug statistical table is implemented, and the fourth group combination is known from the statistical table. The formula can quickly and effectively improve the treatment of menstrual pain syndrome in the fourth stage of tumor-type women in a short period of time; in Figure 6, the fourth group of Chinese herbal medicine extract concentrate composition formula through the symptom ratio of pain symptom treatment can be surpassed or replaced Western medicine Pu Na pain all the effects, but not 48 201221135 There will be a vice-related problem to go to the 'the silk market is more unique. The invention relates to a formula for treating a slime-skin composition of a stalking disease and a fresh-selling ship composition, and the formula composition is compatible with the pathological and pharmacological machine and the safe dosage range, and is specially used for treating the female field with four fine noodles. The compound, the towel extracting oblique oblique herbal towel contains: 1 to 12g of angelica, 3~12g of peach kernel, 3~1g of Sichuan, 2~i〇g of eucalyptus, 2~10g of cassia twig, peony Skin 2~9g, 2~1〇g, Puhuang 2~9g, Achyranthes 2, Red peony 15~8g' Wulingzhi 14~8g, safflower 12, Bai Shi, Purple _~ Ring, Cinnamon 2~5g, Myrrh. 〜5~10g, Youshou 〇5~1〇g, Houpu 〇3~ licorice ~ 12g, dried ginger αΐ~1〇9, ginseng α5~15g, betel nut 3~15g , Astragalus 5 ~ 峋 wind W~1Qg, woody α3~9g, black sputum σ3~·crust 〇3, small _ 〇]~ 3g composition, etc., for the hair treatment of women _ disease The middle grass is transferred to a fourth set of composition formulations of the concentrated composition. The clinical implementation of the mouth is as follows: Example 1 Subject: Miss Cai, born in 1967, 42 years old, height 165cm, weight 55kg

居住地:桃園縣揚_,職業:上班族,疾病:無重大疾病。 生理期臨床錄:為第令般侧各自魏軸、細、勝痛、目 眩蓉。 治療方式養竹-纟磁合物财萃取濃縮帽,早、巾、晚各 生理期來潮當日服用’於第一魏用後25〜3〇分鐘後止痛,不再頭痛、腰 =目’可持續至晚上服賴都無不適感,舰量嗎増加排 冷3=__二遺11,鮮賴,即停11;晴熬夜與喝 -人月.生理期來潮當日’經期正常,至今症狀已完全改善。 49 201221135 由上述實驗結果:證實第—組組合物配方萃取濃縮中藥,有效 =7⑽雜痛錄,可她卿—^般。 受試者:P東小姐’ 1992出生’ 18歲,身高163cm,體重47吻 居住地:台北縣新莊市,職業:學生,疾病:無重大疾病。 生理期臨床症狀:為第一期_^型經痛’乳魏痛、頭痛 '勝痛、目 痛、手腳發冷、經期延後、失眠、情緒低潮等。 治療方式:經投予第-組組合物配方萃取填縮帽,早、中、晚各、,於 生理期來潮當日服用,於第-次服用後約3〇〜35分鐘後止痛,询= 冷、情緒舒暢,月經量明顯正常;持續服用第三天無不適感。 次月:生理触«日’因無法忍耐不吃冰與喝冷飲,雖經期正常,益手腳 發冷、頭痛、目眩、情緒低潮錢等症狀,尚_ , 經再服用藥劑後已完全改善。 由上述實驗結果:證實第-她合物配方萃取濃齡藥;可有效改善第一 期-般型經痛症狀,因吃冰與喝雜,引起手腳發冷、麵、目眩、月轉 痠背痛、腹痛、情緒低潮_等症狀,可有效改善經痛症候群病症。 實施例3 受試者:劉小姐,1987出生,23歲,身高160cm,體重6〇kg 居住地:台中市南區。職業:外從事業務工作。疾病:無重大疾病。 生理期臨床症狀:為第-期-般値痛;常喝冷飲,乳房脹痛、頭痛 '展痛、 目眩、腹痛、乳祕顧、手腳發冷、月經量少、纖延後、失眠、蠻臀寡 歡、情緒低潮等。 治療方式:經投予第一組組合物配方萃取濃縮中藥,早、晚各3g,於生理 期來潮當曰服用,於第一次服用後約30〜35分鐘後止痛,手腳發不再冷、 情緒舒暢,可持續至晚上服用第二次藥都未有不適感,月經量明顯增加排出 量;持續服用至第三禾a免上,月經量正常,無不適感。 201221135 次月:生理期來潮當日’經期正常,尚有腰痛 时 織已完全改善。 她 由上述實驗絲韻第-她合物_取濃_,可姐改盖月經 勝痛、胸悶痛情形,可有效改善第-期—般型經痛症候群病症。 實施例4 受試者:蔡小姐,測出生,27歲,身高158加,體重娜 居住地:台北縣新莊市。職業··上班須在冷氣紅作。疾病:無重大疾病。 生理期臨床症狀m般型、喜歡喝冷飲,乳絲痛、頭痛、腰Place of residence: Taoyuan County Yang _, occupation: office workers, disease: no major diseases. Clinical record of the physiological period: for the order of the first side of the Wei axis, fine, pain, glare. Treatment method: Bamboo, 纟 纟 合物 萃取 萃取 萃取 , , , , , , , 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早 早Until the evening service, there is no discomfort, the volume of the ship is not too cold, 3=__two left, fresh, that is, stop 11; sunny night and drink - human month. improve. 49 201221135 From the above experimental results: Confirm that the first group of formula extracts concentrated Chinese medicine, effective = 7 (10) miscellaneous pain record, but her Qing-^. Subject: Miss P Dong 'born in 1992' 18 years old, height 163cm, weight 47 kiss Place of residence: Xinzhuang City, Taipei County, occupation: student, disease: no major diseases. Physiological symptoms: the first phase of _^ type of menstrual pain, milk, Wei, headache, pain, eye pain, cold hands and feet, menstrual delay, insomnia, low mood and so on. Treatment: After the first-group composition is added, the caps are filled, early, middle and late, and taken on the day of the menstrual period. After the first dose, about 3~35 minutes after the first dose, the pain is relieved. The mood is comfortable and the menstrual flow is obviously normal; there is no discomfort after taking the third day. The next month: Physiological touch «Japan' because of the inability to bear not eat ice and drink cold drinks, although the menstrual period is normal, the hands and feet are cold, headache, dizziness, low tide and other symptoms, still _, after the drug has been completely improved. From the above experimental results: confirm the first-she formula extraction of the age-enhancing drug; can effectively improve the first-stage type of menstrual pain symptoms, due to eating ice and drink, causing cold hands, feet, dizziness, acid reflux and back pain Symptoms such as abdominal pain, low mood and other symptoms can effectively improve the symptoms of menstrual pain. Example 3 Subject: Miss Liu, born in 1987, 23 years old, height 160cm, weight 6〇kg Place of residence: Southern District of Taichung City. Occupation: Working outside the business. Disease: No major illness. Clinical symptoms in the physiological period: for the first period - general pain; often drink cold drinks, breast pain, headache 'showing pain, dizziness, abdominal pain, milk secrets, cold hands and feet, less menstruation, postponement, insomnia, pretty Hip ecstasy, low mood, etc. Treatment: After the first group of composition is administered, the concentrated Chinese medicine is extracted, 3g in the morning and evening, and taken during the physiological period. After 30~35 minutes after the first taking, the pain is relieved, and the hands and feet are no longer cold. Emotional comfort, sustainable until the second dose of medicine at night, no discomfort, menstrual volume significantly increased discharge; continue to take to the third Wo a free, normal menstrual volume, no discomfort. 201221135 Next month: On the day of the menstrual period, the menstrual period is normal, and there is still a slight improvement in the back pain. She is from the above-mentioned experimental silk rhyme-she compound _ take _, can change the menstrual period to overcome the pain, chest tightness, can effectively improve the first-stage-type dysmenorrhea syndrome. Example 4 Subject: Miss Cai, measured birth, 27 years old, height 158 plus, weight Na Residence: Xinzhuang City, Taipei County. Occupation··Working in the air must be done in the air. Disease: No major illness. Physiological period, clinical symptoms, m-like, like to drink cold drinks, milk pain, headache, waist

痛、目眩、Μ、手腳發冷、聽量少、血塊、閉經、經期延後、失眠、營 鬱寡歡、情緒低潮暴躁等。 J 治療方式:經射第二她合物配方萃取濃縮中藥,早、.45g,於生理 期來潮當日顧,第-魏雌25〜3Q分鐘後止痛,手腳發不再冷、情緒 舒暢’可持續至晚上顧第二次藥都未有不適感,月經量明顯增加、血塊排 出量增;服用至第二天晚上,月經量正常,娜咸少,_紅血;服用至第 三天晚上,無不適感。 人月·生理期來潮當日,經期正常,無不適感,尚有月經量少血塊情形,經 再用藥劑後已完全改善。 2上述實驗結果:證實第二組組合物配方萃取濃财藥,可有效改善月經 里viai鬼情形’可有效改善第—期__般型軸症候群病症。 實施例5 受試者:戴小姐’ 1985出生,25歲,身高158cm,體重46kg 居住地:台北市文山區。職業:藥房工作。疾病:無重大疾病。 生_臨床症狀:綠一期一般型經痛;常喝綠,乳房脹痛、目眩頭痛、 麟老痛、腹痛、手腳發冷、經期延後、失眠、情緒低潮等。 治療方式:經投予第二組組合物配方萃取漢縮中藥,早、中、晚各i 8g,於 生理期來潮當日服用,於第一次服用後30分鐘後止痛,手腳發不再冷、情 51 201221135 緒舒暢’可持’續至服用第二次藥都未有不適感月經量明顯增加;持續至第 二天晚上,無*適感’月'經量明顯正常;持續顧至第三天晚上,無不適感。 人月生理期來潮虽日’經期正常,尚有月觸嫉情形,經再服用藥織已 完全改善。 由上述實驗絲:證實第二她合物财萃取雜巾藥,可雜改善月經 祕背痛,可有效改善第一期一般型經痛症候群病症。 實施例6 受辦:李小姐,1987出生,23歲,身高158cm,體重52kg ;與其姐妹 三人等 居住地.台北縣。職業:上班族。疾病:與其姐妹三人等,皆無重大疾病。 生理期臨床症狀:為第一期一般型經痛;常熬夜讀書與常喝冷飲,各自有乳 房脹痛、有頭痛、職、目眩、手腳發冷、冒冷汗、腹絞痛會在地上翻滚、 月經量少、血塊、經期繁亂、情緒低潮暴躁等。 治療方式:各織予第二她合_访萃取濃縮巾藥,早、巾、晚各%, 於生理期來潮當日服用’於第-錄用後30〜45分鐘分鐘後止痛,手腳 發不再冷、情緒舒暢,可持續至晚上服用藥前尚有有輕娜痛、腹痛的輕微 不適感’月經量明顯增加、血塊排出量增加;持續服用至第二天晚上,不適 感減輕,月經量明正常,錢減少;持續顧至第三天晚上,無不適感,同 時戒除熬夜與喝冷飲習慣。 次月:生理期來潮當日,經期正常,至今姐駐人等不喝冷飲,症狀已完全 改善。 由上述實驗結果:證實第二組組合物配方萃取濃縮中藥,可有效改善第一 期一般型經痛症狀’可有效改善經痛症候群病症。 實施例7 党試者:蕭小姐,1967出生’ 43歲,身高153cm,體重50kg。 居住地:台北縣。職業早餐業者需清早起床工作。疾病:有子宮下垂、子 52 201221135 宮肌瘤病症。 生理期臨床症狀:為第二期非出錄肌瘤型經痛;有乳房張痛、職、勝痛、 目眩、手腳發冷、冒冷汗、腹絞痛、月經量少、血塊、經期繁亂、來潮當曰 有血漏、滴漏等症狀。 治療方式:⑴織料二她合物g访萃取濃縮帽,早、晚各3g,於生 理期來潮當日顧,於第-魏驗約45乡分鐘後止痛可持續約8小 時後症狀又復發,需再服用幫助止痛;(2)改建議早 '中、晚各24g連續 顧二天’於—天第-魏崎約3Q多分鐘後止痛,願三天經痛症狀已 完全無,血漏、滴漏等症狀明顯改善。 次月··改建議早、中、晚各3g連續服用7天,生理期來潮當日按時服用要, 經期正吊,症狀已全改善無血漏、滴漏症狀,子宮肌廇有萎縮現象。 後連續三個月:都相同用藥,子宮肌瘤有明顯萎縮。 由上述實驗結果:證實第二組組合物配方萃取濃縮中藥,可有效改善第二 期肌瘤型經痛症狀,可有效改善月經滴漏及改善經痛症候群病症,證明只要 生理期來潮子宮排經血、剝落正常,是可有效幫助子宮肌瘤萎縮。 實施例8 受試者··蔡小姐,1981出生,29歲,身高162cm,體重50kg。 居住地:台北縣。職業:學校助教。疾病:子宮卵巢巧克力囊腫病症。 生理期臨床症狀:為第二期非出血性肌瘤型經痛;固定每月食用四物飲與常 喝冷飲;乳房脹痛、有頭痛、腰痛、目眩、手腳發冷、冒冷汗、腹絞痛月 經量少、血塊、經期繁亂、情緒低潮暴躁等。 治療方式:(1)經投予第二組組合物配方萃取濃縮中藥,早、晚各3g,於生 理期來潮當曰服用,於第一次服用後約45多分鐘後止痛,但持續約4 5 小時後症狀手腳發冷、冒冷汗、腹絞痛又復發,連續服用三天症狀才完全 舒緩,經期過後腹部也會有不適感,往後連續三個月都是服藥後獲得舒 緩’但若無服藥仍會疼痛,故建議她到大型醫院檢查,才得知為卵巢左、 53 201221135 右各有5克力囊腫’ 8公分與14公分;(2)建議手術切除治療,切除後治療 見主射W體素的4經針二個月’服用消炎止痛藥,會有維虛弱無力、全 身潮熱如科期-般*贼。⑶二则麟_帛二她合祕方萃取濃 縮中藥,早、晚各4.5g,漸恢復正常中。 隔月.生理期來齡日,經期正常,症狀已大幅改善。 由上述實驗、,,α果· a登實第二組組合物配方萃取漢縮中藥,可有效改善第二 期肌瘤型經痛症狀’雖可有效改善經痛症候群病症,但幫助過于嚴重的子宮 肌瘤萎縮尚須努力。 實施例9 受錄:洪小姐’ 1988出生,22歲,身高156cm,體重63kg。 居住地.麵縣。職業:無工作。疾病:有子宮下垂、子宮肌瘤與印巢巧克 力囊腫病症。 生理期臨床症狀:為第三期丨血,_瘤型經痛;為絲遺傳病;有乳房服痛、 有2期頭痛、全身腰酸背痛、目眩、手腳發冷' 冒冷汗、舰腹絞痛;月經 來前出血不止、血漏、滴漏、經期繁亂、情緒低潮祕、失眠_狀。 治療方式:經投予第三組組合物配方萃取濃縮中藥,早、中、晚各%,於 生理期來潮當日顧’於第-魏用後約45纽鐘後開始緩和止痛,持 續服用至第三次Μ ’月經出血明顯改善減少;持續顧至第二天晚上,不適 感月經出血明崎止’持續服用至第三天晚上,不適感漸減輕,連續 服用7日後’月經不適感明顯改善約85〇/〇,尚有輕微腹脹、失眠等的情況。 後建議每舰生理期來麟’連續服㈣三她合物配方萃取濃縮中藥卜 15曰’早、中、晚各4.5g,直到經期正f,症狀完全改善為止。 由上述實驗結果:證實第三組組合物配方萃取濃縮中藥,可有效改善第三 期出錄_型經痛鎌,可有效改善脸出血、血漏、滴漏的情形。 實施例10 受試者:周小姐,1962出生,47歲,身高152cm,體重4gkg。 54 201221135 居住地:台北縣。職業:百貨專櫃小姐後轉早餐業服務。疾病:子宮下垂、 子宮肌瘤纖維囊腫、卵巢水瘤及第一期乳癌約0.8cm病症。 生理期臨床症狀:介於第二期非出血性肌瘤型與第四期腫瘤型經痛間;有乳 房脹痛、頭痛、腰痛、目眩、手腳發冷、冒冷汗、腹絞痛、月經量少、血塊、 經期繁亂等症狀。 治療方式:經投予第二組組合物配方萃取濃縮中藥,早、晚各6g,於生理 期來潮當曰服用,於第一次服用後約40多分鐘後止痛,可持續約7小時 後症狀又復發’需再服用第二劑幫助止痛症狀;改建議早、中、晚各4 5Pain, dizziness, convulsions, cold hands and feet, low hearing, blood clots, amenorrhea, delayed menstruation, insomnia, stagnation, and low mood. J treatment: the second herb compound extracts concentrated Chinese medicine, early, .45g, in the physiological period when the tide, the first - Wei female 25~3Q minutes after the pain, the hands and feet are no longer cold, emotionally comfortable 'sustainable Until the second night, there was no discomfort in the second drug, the menstrual volume increased significantly, and the blood clots increased. After the second night, the menstrual volume was normal, Na Xian was less, _ red blood; taking until the third night, no Discomfort. On the day of the menstrual period and the physiological period, the menstrual period is normal, there is no discomfort, and there is still a small amount of menstrual blood clots, which has been completely improved after re-using the drug. 2 The above experimental results: It is confirmed that the second group of compositions is formulated to extract concentrated drugs, which can effectively improve the situation of viai ghosts in menstruation, which can effectively improve the first-stage __-type syndrome syndrome. Example 5 Subject: Miss Dai, born in 1985, 25 years old, height 158cm, weight 46kg Residence: Wenshan District, Taipei City. Occupation: Pharmacy work. Disease: No major illness. Health _ clinical symptoms: green one-stage general menstrual pain; often drink green, breast pain, vertigo headache, Lin old pain, abdominal pain, cold hands and feet, menstrual delay, insomnia, mood low tide. Treatment: After the second group of composition is administered, the Chinese medicine is extracted, 8g in the morning, middle and evening, taken on the day of the menstrual period. After 30 minutes after the first dose, the pain is relieved, and the hands and feet are no longer cold.情51 201221135 绪舒畅 '可持' continued to take the second drug without discomfort, the menstrual volume increased significantly; continued until the next night, no * sensible 'month' volume was obviously normal; continue to take care of the third No night, no discomfort. Although the menstrual period of the human period is normal, the menstrual period is normal, and there are still months of touching, and the drug has been completely improved. From the above experimental silk: confirm the second her compound extraction of the medicinal herbs, can improve the menstrual secret back pain, can effectively improve the first period of general dysmenorrhea syndrome. Example 6 Attendance: Miss Li, born in 1987, 23 years old, height 158cm, weight 52kg; living with her sisters, etc. Taipei County. Occupation: office workers. Disease: There are no major diseases with the three of his sisters. Physiological symptoms: the first period of general type of menstrual pain; often staying up late reading and drinking cold drinks, each have breast pain, headache, job, dizziness, cold hands and feet, cold sweat, abdominal cramps will roll on the ground, menstruation Less, blood clots, menstrual periods, mood swings and so on. Treatment: Each woven to the second she combined _ interview extract concentrated towel, morning, towel, night%, on the day of the physiological period of the day to take 'after the first 30-45 minutes after the use of pain, pain, hands and feet are no longer cold Sustained mood, sustainable until the evening before taking the medicine, there is still a slight discomfort of mild pain and abdominal pain, 'the menstrual volume increased significantly, and the blood clots increased. Continued to the next night, the discomfort is relieved, and the menstrual volume is normal. , the money is reduced; continue to care for the third night, no discomfort, while abstaining from staying up late and drinking cold drinks. The next month: On the day of the menstrual period, the menstrual period is normal, so the sisters are not drinking cold drinks, and the symptoms have completely improved. From the above experimental results: it was confirmed that the second group composition extracting and concentrating the traditional Chinese medicine can effectively improve the first-stage general type of menstrual pain symptoms, which can effectively improve the symptoms of menstrual pain. Example 7 Party tester: Miss Xiao, born in 1967, '43 years old, 153 cm in height and 50 kg in weight. Place of residence: Taipei County. Occupational breakfast operators need to get up early in the morning. Disease: There is uterine prolapse, son 52 201221135 uterine fibroid disease. Physiological symptoms: the second phase of non-recorded fibroids of menstrual pain; breast pain, job, pain, dizziness, cold hands and feet, cold sweat, abdominal cramps, less menstrual flow, blood clots, menstrual periods, chaos When there are blood leaks, dripping and other symptoms. Treatment: (1) woven material 2 her compound g visit extraction and concentration cap, 3g in the morning and evening, in the physiological period of the day when the tide, after the first - Wei test about 45 townships, the pain can last for about 8 hours after the symptoms relapse, Need to take more help to relieve pain; (2) suggest that early 'in the middle and late 24g for two consecutive days' in - Tiandi - Weiqi about 3Q more minutes after the pain, I hope the symptoms of three days of menstruation is completely absent, blood leakage, drip, etc. Significant improvement in symptoms. The next month··Recommended to recommend 3g for 3 days in the morning, midnight and evening. The menstrual period of the menstrual period should be taken on time. The menstrual period is hanging, the symptoms have all been improved without blood leakage and dripping symptoms, and the uterine tendon has atrophy. After three consecutive months: all the same medication, uterine fibroids have obvious atrophy. From the above experimental results: It is confirmed that the second group of composition extracting and concentrating traditional Chinese medicine can effectively improve the second-stage fibroid-type menstrual pain symptoms, can effectively improve menstrual drip and improve the symptoms of menstrual pain syndrome, and prove that as long as the menstrual period of the uterus drains blood and exfoliates normally, It is effective in helping uterine fibroids to shrink. Example 8 Subject · Miss Cai, born in 1981, 29 years old, 162 cm in height and 50 kg in weight. Place of residence: Taipei County. Occupation: School Assistant. Disease: Uterine ovarian chocolate cyst disease. Physiological symptoms: second-stage non-hemorrhagic myoma-type menstrual pain; fixed monthly consumption of four drinks and regular cold drinks; breast pain, headache, low back pain, dizziness, cold hands and feet, cold sweat, abdominal cramps Less menstrual flow, blood clots, menstrual periods, and low mood. Treatment methods: (1) After the second group of composition is administered, the concentrated Chinese medicine is extracted, 3g in the morning and evening, and taken during the physiological period, and the pain is relieved after about 45 minutes after the first taking, but lasts about 4 After 5 hours, the symptoms of hands and feet are cold, cold sweat, abdominal cramps and recurrence. After taking the symptoms for three consecutive days, the symptoms are completely relieved. After the menstrual period, the abdomen will have discomfort. After three consecutive months, the patient will be relieved after taking the medicine. No medication still hurts, so it is recommended that she go to a large hospital for examination, only to know that the ovary left, 53 201221135 right 5 grams of cysts '8 cm and 14 cm; (2) recommended surgical resection, treatment after resection see the main The injection of W voxel for 4 months and the needle for two months 'take anti-inflammatory painkillers, there will be weak and weak, whole body hot flashes such as the period of time - like * thief. (3) Er Zelin _ 帛 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她 她Every other month, the menstrual period is normal, the menstrual period is normal, and the symptoms have been greatly improved. According to the above experiment, the extraction of Han Chinese traditional medicine by the second group composition of α fruit·a Dengshi can effectively improve the second stage of myoma-type menstrual pain symptoms, although it can effectively improve the symptoms of menstrual syndrome, but help the uterus that is too serious. It is still necessary to work hard on fibroids. Example 9 Recorded: Miss Hong's born in 1988, 22 years old, height 156cm, weight 63kg. Residence. No. County. Occupation: No job. Disease: There are uterine prolapse, uterine fibroids and India's nesting chocolate cyst disease. Physiological symptoms: the third stage of blood stasis, _ tumor type menstrual pain; silk genetic disease; breast pain, 2 headaches, back pain, dizziness, cold hands and feet ' cold sweat, stern colic ; bleeding before menstruation, blood leakage, dripping, menstrual disorders, emotional low tide secret, insomnia _ shape. Treatment: After the third group of composition is administered, the concentrated Chinese medicine is extracted, and the early, middle and late% are used. After the onset of the physiological period, the patient begins to relieve the pain after about 45 hours after the first use of Wei-Wei. Three times Μ 'menstrual bleeding significantly improved; continued to the next night, discomfort menstrual bleeding Mingqi stop 'continuous taking until the third night, the discomfort gradually reduced, after 7 days of continuous use, menstrual discomfort improved significantly 85〇/〇, there is still a slight bloating, insomnia and so on. After the suggestion that each ship's physiological period comes to Lin's continuous service (four) three her compound formula extract concentrated Chinese medicine Bu 15曰' early, middle and late 4.5g, until the menstrual period f, the symptoms are completely improved. From the above experimental results: it was confirmed that the third group of compositions was extracted and concentrated, which could effectively improve the third stage of phlegm-type warts, which can effectively improve facial bleeding, blood leakage and drip. Example 10 Subject: Miss Zhou, born in 1962, 47 years old, height 152 cm, weight 4 gkg. 54 201221135 Residence: Taipei County. Occupation: After the department store counter, the breakfast service will be transferred. Disease: uterine prolapse, uterine fibroids fibrous cyst, ovarian water tumor and first stage breast cancer about 0.8 cm. Physiological symptoms: between the second non-hemorrhagic myoma type and the fourth stage of the tumor type of pain; breast pain, headache, low back pain, dizziness, cold hands and feet, cold sweat, abdominal cramps, less menstrual flow , blood clots, menstrual disorders and other symptoms. Treatment: After the second group of composition is administered, the concentrated Chinese medicine is extracted, 6g in the morning and evening, and taken during the physiological period. After about 40 minutes, the pain is relieved after the first dose, and the symptoms last for about 7 hours. Recurrence 'need to take a second dose to help relieve pain symptoms; change to recommend early, middle and late 4 5

〜6g連續顧三天,於二天第一次服用後約4〇多分鐘後止痛,服用三天 經痛症狀已明顯改善。 次月:改投予第四組組合物配方萃取濃縮中藥,生理期來潮前開始納夺服 用’建議早、中、晚各5g連續服用7〜15曰,結果經期正常,經痛症狀明 顯改善。 改早、中、晚各5g ’其子宮肌瘤纖維囊 後連續幾個月:建議第四組組合物配方萃取濃縮中藥, 連續服用7〜15天’按時服用以來,結果乳癌不再惡化 腫、卵巢水瘤不再增生,並且有受抑制現象。 由上述實驗結果 "艰只本口組組5柳配万卒取濃縮中藥,可有效改善介於 第二期非出錄肌瘤酿第四期腫瘤型間經痛症狀,可有效抑制改善乳癌、、 子宮肌瘤纖維囊腫、M水瘤經痛症候群病症,刻只要生理期糊子宮^ 經金、剝落正常,是可姐伽子宮抑制肌瘤增生。 實施例表3 痛效果 約10小時 約8小時~6g for three days in a row, after about the first time in two days, after about 4 minutes, the pain is relieved. After taking the three days, the symptoms of menstrual pain have been significantly improved. The following month: the fourth group of composition formula was introduced to extract concentrated Chinese medicine, and the physiological period began to take the service before the tide. It is recommended to take 7~15曰 for 5g in the morning, middle and night. The result is normal, and the symptoms of menstrual pain are obviously improved. Change 5g in early, middle and late 'after uterine fibroids fiber sac for several months: It is recommended to extract concentrated Chinese medicine in the fourth group of formulas, take 7~15 days in a row. Since the time taken, the breast cancer no longer worsens. Ovarian tumors no longer proliferate and are inhibited. From the above experimental results " Difficult Benkou group 5 Liuxuanwan stroke concentrated Chinese medicine, can effectively improve the second phase of non-recorded fibroids, the fourth stage of tumor type of menstrual pain symptoms, can effectively inhibit the improvement of breast cancer, , uterine fibroids fibrous cyst, M water tumor menstrual pain syndrome, engraved as long as the physiological period paste uterus ^ gold, peeling normal, is the sister gamma uterus inhibit fibroid hyperplasia. Example Table 3 Pain effect About 10 hours About 8 hours

經痛期別 受試者含 卞取干#/〒 人數比率 第一期一般型 經痛 36人 69% 第二期非出血 8人 15% 止痛 、約35分n 止痛_ 約35分# 55 201221135 性肌瘤型經痛 止痛 3〜7日 第三期出血性 肌瘤型經痛 5人 10% 約45分鐘 止痛、止血 約7小時 建議 7〜15日 87% 第四期腫瘤型 經痛 3人 5% 需長時間用藥或手術切除治療,目前發現腫 瘤,都採用子宮手術切除治療,因而臨床實施 例僅有止痛部份,治療腫瘤成效比率資訊有限。 實施例表4 治療女性經痛疾病的中草藥萃取濃縮組合物受試實施例52例治療效果統計表 臨床經 痛項目 經痛病 症人數(人) 第一組組合 物治療效果 第二組組合 物治療效果 第三組組合 物治療效果 第四組組合 物治療效果 乳房脹痛 51 98% 98% 97% 96% 頭痛 51 98% 98% 97% 96% 目眩 45 87% 98% 89% 60% 嘔吐 45 87% 98% 89% 60% 腰痠背痛 50 97% 98% 93% 95% 腹痛 51 96% 98% 93% 95% 冒冷汗 44 96% 98% 91% 60% 手腳發冷 46 96% 98% 87% • 60% 食慾失常 28 89% 89% 79% 60% 月經提前 51 98% 98% 93% 60% 月經延後 52 98% 98% — 60% 月經量少 52 98% 98% — 93% 血塊 43 98% 98% — 93% 閉經 31 87% 87% — 60% 白帶 48 96% 96% 93% 95% 情緒障礙 50 90% 90% 92% 60% 鬱鬱寡歡 49 90% 90% 96% 60% 脾氣暴躁 50 90% 90% 90% 60% 睡眠障礙 44 97% 98% 91% 60% 子宮肌瘤 8 75% 75% 63% — 巧克力囊腫 8 75% 75% 63% — 子宮下垂 8 63% 63% 63% — 月經時量多 5 — — 80% 60%Perioperative period, other subjects with sputum dry #/〒 ratio of the first period of general type of menstrual pain 36 people 69% second stage non-bleeding 8 people 15% analgesic, about 35 points n pain relief _ about 35 points # 55 201221135 muscle Tumor type menstrual pain and pain 3~7 days third stage hemorrhagic myoma type menstrual pain 5 people 10% about 45 minutes pain relief, hemostasis about 7 hours recommended 7~15 days 87% fourth stage tumor type menstrual pain 3 people 5% long time Medication or surgical resection, the current discovery of tumors, are treated with hysterectomy, so the clinical examples only have analgesic part, and the information on the rate of treatment of tumors is limited. EXAMPLES Table 4 Chinese herbal medicine extract concentrated composition for treating women with menstrual pain test Example 52 cases of treatment effect statistics table clinical menstrual pain item number of menstrual pain patients (human) first group composition therapeutic effect second group composition therapeutic effect third group Composition Treatment Effect Group 4 Composition Treatment Effect Breast Pain 51 98% 98% 97% 96% Headache 51 98% 98% 97% 96% Eyes 45 87% 98% 89% 60% Vomiting 45 87% 98% 89 % 60% Back pain 50 97% 98% 93% 95% Abdominal pain 51 96% 98% 93% 95% Cold sweat 44 96% 98% 91% 60% Hand and foot chill 46 96% 98% 87% • 60% Appetite disorders 28 89% 89% 79% 60% Menstruation 51 98% 98% 93% 60% Menstrual delay 52 98% 98% — 60% Menstrual volume 52 98% 98% — 93% Blood clot 43 98% 98% — 93% Amenorrhea 31 87% 87% — 60% Leucorrhea 48 96% 96% 93% 95% Emotional Disorder 50 90% 90% 92% 60% Unhappy 49 90% 90% 96% 60% Grumpy 50 90% 90 % 90% 60% Sleep Disorder 44 97% 98% 91% 60% Uterine Fibroids 8 75% 75% 63% - Chocolate Cysts 8 75% 75% 63% - Uterine Droop 8 63% 63% 63% - Menstrual Time More 5 – 80% 60%

56 201221135 質淡 5 — ----:-—1 80% 60% 血崩 5 一 — 80% 60% 血漏 5 — — 97% 60% 滴漏 11 ~- — 97% 60% 出血 5 — - 80% 60% 腫瘤 3 — — 一 子宮腺瘤 2 — — _ 平均治癒率 91% 92% 86% (術前)70% 以上所實施例僅為本發明組合物藥理效果之若干實施態樣,非用以 •=定本發明實施之範圍’大凡依本發明申請專利範圍及本發明說明書内 容所揭示之實施例思想而為之簡單的等效變化與修飾,應仍屬本創作專 利涵蓋之範圍。 【圖式簡單說明】 圖1是本發明治療女性經痛疾病的中草藥萃取濃縮組合物之臨床病症分佈 統計示意圖;及 鲁 ® 2為治療女性經痛疾病的中草藥萃取濃縮組合物之臨床病症分佈比 率不意圖;及 圖3是本發明治療女性經痛疾病的中草藥萃取濃縮組合物之第一組組合物 配方療效統計示意圖;及 圖4是本發明治療姐經痛疾病的中草藥萃取濃縮組合物之第二組組合物 配方療效統計示意圖;及 圖5是本發明治療女性經痛疾病的中草藥萃取濃縮組合物之第三組組合物 配方療效統計示意圖;及 圖6是本發明治療女性經痛疾病的中草藥萃取濃縮組合物之第四組組合物 配方療效統計示意圖。 57 201221135 【主要元件符號說明】 七、申請專利範圍: 1、纏細巾草_取濃驗合物齋她合物配方;其配 痛疾症笛:病St藥理機轉與安全劑量範圍使用原則配伍,專供治療女性經 歸2 ”一期一般型經痛’專用的中草藥萃取濃縮組合物,其中包含有:當 = rr2〜12g'^1〜10gw〇·8,··7,、 丹皮〇.7〜9g、的a7〜1Qg、蒲黃Q 6〜9g、牛膝 〜8g、五靈脂G.4〜8g、邱cm β ^ 加〜6g、M a3〜6g , : 6綱·3〜69、顺03今白 0^ / 4 5g、白⑽〜4.5g、厚朴〇·2,、炎甘草 …g等組成,專供治療第_期—般型經痛、佔經痛人數 樂卒取濃縮配方組合物; 綱τ旱 2 、如申鱗概娜彳項騎之轉姐軸 物之第-組配方組合物,其製細m _ 早樂卒取濃縮組合 ㈣.凿# 再製備劑型可為飲片煎劑或濃縮煎船採用科學 濃=細水萃方式或及食用酒萃方式製備,採用科學中藥 二二卒取 '分m乾燥等工程所取得之中藥顆粒劑, 加工成片劑、㈣丨或膠囊等劑型;方便於攜帶、運輸 、、 健食品或藥品。 。口、保 3 —種治療女性經痛疾病的中草藥萃取濃縮組合物之第二組組合物^ 方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,專供治療女性= 痛疾病第二_出血,__,相的巾轉萃取濃驗合物,其: 有:當歸2,、桃仁12〜12g、㈣s♦延胡f Q 8〜% = :响、牡丹皮a7〜9g'白⑽〜,蒲黃〇 6〜9g、牛膝〇枝 柄0.4〜8g、五靈脂a4〜8g、紅花〇 4,、解〇 3〜6g、 5856 201221135 淡淡 5 — ----:-—1 80% 60% blood fall 5 one — 80% 60% blood leak 5 — — 97% 60% drip 11 ~- — 97% 60% bleeding 5 — — 80% 60% tumor 3 - a uterine adenoma 2 - _ average cure rate 91% 92% 86% (pre-operative) 70% or more The examples are only a few examples of the pharmacological effects of the composition of the present invention, not used The scope of the invention is to be construed as being limited by the scope of the invention and the scope of the invention disclosed herein. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic diagram showing the distribution of clinical symptoms of a Chinese herbal medicine extract concentrated composition for treating menstrual pain in women according to the present invention; and Lu Hua 2 is a non-intentional distribution ratio of a clinical herbal extract concentrate composition for treating menstrual pain in women. And FIG. 3 is a schematic diagram showing the therapeutic effect of the first group composition composition of the Chinese herbal medicine extract concentrated composition for treating menstrual pain in the present invention; and FIG. 4 is a second group composition of the Chinese herbal medicine extract concentrated composition for treating the postmenstrual pain disease of the present invention; Schematic diagram of the efficacy of the formula; and FIG. 5 is a schematic diagram showing the efficacy of the third group of the composition of the Chinese herbal medicine extract concentrated composition for treating menstrual pain in the present invention; and FIG. 6 is the first embodiment of the concentrated extract of the Chinese herbal medicine for treating menstrual pain in the present invention. Schematic diagram of the efficacy of the four groups of compositions. 57 201221135 [Explanation of main component symbols] VII. Patent application scope: 1. Wrap the fine towel grass _ take the complex test compound formula; it is equipped with painful flu: disease St drug machine transfer and safe dose range use principle Compatibility, specially designed for the treatment of female menstruation 2 "one-stage general type of pain" special Chinese herbal extract concentration composition, including: when = rr2~12g'^1~10gw〇8,···7,, 丹皮〇 .7~9g, a7~1Qg, Puhuang Q 6~9g, Achyranthes ~8g, Wulingzhi G.4~8g, Qiu cm β ^ plus ~6g, M a3~6g , : 6 Gang·3~ 69, Shun 03 Jinbai 0^ / 4 5g, white (10) ~ 4.5g, Houpu 〇 · 2,, licorice ... g, etc., for the treatment of the first _ period - general type of menstrual pain, the number of menstrual pain Formulation composition; Gang τ drought 2, such as Shen Tien Na Na 彳 之 之 转 转 转 轴 轴 轴 轴 轴 轴 轴 轴 轴 轴 轴 组 组 组 组 第 第 m m m m m m m m m m m m m m m m m m m m m m m m m m m m m m Or the concentrated frying vessel is prepared by scientific concentration=fine water extraction method or edible wine extraction method, and the traditional Chinese medicine granules obtained by the scientific Chinese medicine 22nd stroke 'mining m drying and the like are processed into Formulations, (four) sputum or capsules; convenient for carrying, transporting, healthy foods or medicines. kou, Bao 3 - a second group of Chinese herbal extracts concentrated composition for treating menstrual pain diseases It is compatible with the principle of using the pharmacological machine and the safe dose range. It is specially used for the treatment of female = painful disease. The second _ bleed, __, phase of the towel to extract concentrated complex, its: There are: Angelica 2, peach kernel 12~12g, (four) s ♦延胡f Q 8~% = : ringing, peony bark a7~9g' white (10)~, Puhuang 〇 6~9g, Achyranthes chinensis stalk 0.4~8g, Wulingzhi a4~8g, safflower 〇4, Solution 3~6g, 58

Claims (1)

201221135 【主要元件符號說明】 七、申請專利範圍: 1、纏細巾草_取濃驗合物齋她合物配方;其配 痛疾症笛:病St藥理機轉與安全劑量範圍使用原則配伍,專供治療女性經 歸2 ”一期一般型經痛’專用的中草藥萃取濃縮組合物,其中包含有:當 = rr2〜12g'^1〜10gw〇·8,··7,、 丹皮〇.7〜9g、的a7〜1Qg、蒲黃Q 6〜9g、牛膝 〜8g、五靈脂G.4〜8g、邱cm β ^ 加〜6g、M a3〜6g , : 6綱·3〜69、顺03今白 0^ / 4 5g、白⑽〜4.5g、厚朴〇·2,、炎甘草 …g等組成,專供治療第_期—般型經痛、佔經痛人數 樂卒取濃縮配方組合物; 綱τ旱 2 、如申鱗概娜彳項騎之轉姐軸 物之第-組配方組合物,其製細m _ 早樂卒取濃縮組合 ㈣.凿# 再製備劑型可為飲片煎劑或濃縮煎船採用科學 濃=細水萃方式或及食用酒萃方式製備,採用科學中藥 二二卒取 '分m乾燥等工程所取得之中藥顆粒劑, 加工成片劑、㈣丨或膠囊等劑型;方便於攜帶、運輸 、、 健食品或藥品。 。口、保 3 —種治療女性經痛疾病的中草藥萃取濃縮組合物之第二組組合物^ 方組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,專供治療女性= 痛疾病第二_出血,__,相的巾轉萃取濃驗合物,其: 有:當歸2,、桃仁12〜12g、㈣s♦延胡f Q 8〜% = :响、牡丹皮a7〜9g'白⑽〜,蒲黃〇 6〜9g、牛膝〇枝 柄0.4〜8g、五靈脂a4〜8g、紅花〇 4,、解〇 3〜6g、 58 201221135 〜6g '㈣0·3〜6g、紫蘇0.3〜6g、藿香0.3〜6g、生Μ α3〜5、 〜4·59、沒藥α2〜45g、桔梗〇 2〜4 5g、白求〇 2 g =桂 %、灸甘草Μ、陳皮a2〜4.5g、半職〜4㈤〜 乾量0Ό5〜2g、小_ _〜3g等組成;專供治療第二期 9 , 4 經痛、佔經痛人數比率15%的中草鮮取濃縮配方组合物; 瘤型 第-、、疏方組&物,其製備_可為飲片煎劑或濃縮煎劑;採 ^縮其f備方式翻水萃方式或及食賴萃方式製備,_科學中^ :農縮匕括萃取、分離、濃縮、乾燥等工程所取得之中__,瘦再 二!鍵劑或勝囊等劑型;方便於攜帶、運輸、服用的食品、保 二種治療姐顯疾_巾轉萃取濃縮組合物之紅她合物配方;1配 組合物依病理與藥理機轉與安全劑量範圍使用原則配伍,專供治療女性經 痛疾病第三誠血._型經痛,專_t草鮮取濃縮组合物 有:當歸1〜12g、川⑽5〜1〇g、的〇 5〜1〇g、黃彻〜⑷人參〇34 ΤΙΤΓ 〇'4^159 ' 〇'4^159 ' 〇·4^159 ' ^ g莖白⑽〜4.5g、熟地黃a3〜30g、生地黃〇3〜3〇g、振刊3〜响' 〇·2,、炙甘草〇.2〜3g、黃連Q 2〜3g、黃柏Q 2〜9g、靡2〜 二I:复。〇2〜1〇㈣成;專供治療第三期出血性肌瘤型經痛、佔經痛人 數比率10%的中草藥萃取濃縮配方組合物; 6、^請專利細第5項所述之治療女性經痛疾_彻取濃縮組合 =第二減方組合物’其製備_可躲片煎顧濃縮朗:採用科學 樂遭縮其製備方式係用水萃方式或及食用酒萃方式製備,採用科學中藥 ,縮包括萃取、分離、濃縮、乾燥等工程所取得之中藥顆粒劑,經再 :成片劑、錠劑或膠囊等趣;方便於攜帶、運輸、顧 健食品或藥品。 59 201221135 7、 一種治療女性經痛疾病的中草藥 方組合物依病理與藥理機轉與安物之細組組合物配方;其配 痛疾病細期腫瘤型《,相的中草’專供治療女性經 知2〜12g、延胡索2〜10g、桂枝2 有田 错立9。 ug牡丹皮2〜9g、白苟2〜1〇g、 心2〜9g⑽i〜1Gg、桃仁Q9〜i2g、牛膝Q g 五靈脂0.6〜8g、人參〇.3〜15g、肉桂 g赤与〇.6 8g、 化 桂〇·3〜5g、沒藥〇·3〜10g、棺梗〇 3 〜1〇g、紅花0.2〜6g、白定ai〜10g、紫蘇 产硬3 替 y方、綵01〜1〇9、厚朴0.1〜1〇g、 甘卓〇·ι,、檳榔、黃耆ai〜15g、防風◦、木香〇, 〇'1^109 ' 〇〇 〇5^109 ' 0 01-39 軸解觸嫩__萃取濃 8 如申請專利範圍第7項所述之治療女性經痛疾病的中草藥萃取濃縮組合 物=第四組配方組合物,其製備劑型可為飲片煎劑或濃縮煎劑;採用科二 中⑹農縮其製備方式個水萃方式献食_萃方讀備,制科學中二 魏,取、分離、濃縮、乾離程所取得之中軸粒劑,經再 加工成片劑、錠劑或膠囊專劑型;方便於攜帶、谨 健食品或藥品。 運輪、服㈣食品、保201221135 [Explanation of main component symbols] VII. Scope of application for patents: 1. Wrap the fine towel grass _ take the complex test compound formula; it is equipped with painful flu: disease St drug machine transfer and safe dose range use principle compatibility Specially designed for the treatment of female menstruation 2 "one-stage general type of pain" special Chinese herbal extract concentration composition, which includes: when = rr2~12g'^1~10gw〇8,···7,, 丹皮〇. 7~9g, a7~1Qg, Puhuang Q 6~9g, Achyranthes ~8g, Wulingzhi G.4~8g, Qiu cm β ^ plus ~6g, M a3~6g, :6纲·3~69 , Shun 03, white 0^ / 4 5g, white (10) ~ 4.5g, Houpu 〇 · 2,, licorice ... g, etc., for the treatment of the first phase - the general type of menstrual pain, the number of menstrual pain Composition; τ 旱 drought 2, such as Shen Tien Na Na 彳 骑 之 之 转 转 轴 轴 轴 轴 轴 轴 轴 轴 轴 轴 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 第 m m m m m m m m m m m 再 再 再 再 再 再 再 再 再 再The concentrated frying vessel is prepared by scientific concentration=fine water extraction method or edible wine extraction method, and the traditional Chinese medicine granules obtained by the scientific Chinese medicine 22nd stroke 'm dry' and other projects are obtained. It is processed into tablets, (four) sputum or capsules; it is convenient for carrying, transporting, and health foods or medicines. 口,保3 - a second group of Chinese herbal extracts concentrated composition for treating women with menstrual pain The material is compatible with the pathology and pharmacological machine and the safe dosage range. It is specially used for the treatment of women = painful disease, second _ hemorrhage, __, phase of the towel to extract concentrated complex, which: There are: Angelica 2, peach kernel 12~ 12g, (4) s♦ Yanhu f Q 8~% = : ringing, peony bark a7~9g' white (10)~, Puhuang 〇 6~9g, Achyranthes chinense stalk 0.4~8g, Wulingzhi a4~8g, safflower 4,, solution 3~6g, 58 201221135 ~6g '(4) 0·3~6g, perilla 0.3~6g, musk 0.3~6g, raw Μα3~5, ~4·59, myrrh α2~45g, platycodon 2~4 5g, Baiqiu 2 g = Gui%, moxibustion licorice, dried tangerine peel a2~4.5g, part-time ~4 (five) ~ dry volume 0Ό5~2g, small _ _~3g, etc.; specially designed for treatment of the second phase 9 4, Zhongcao fresh concentrated formula composition with menstrual pain and 15% of menstrual pain; tumor type -,, Shufang group & preparation, _ can be decoction or concentrate The preparation method is adopted in the process of extracting and reducing the water preparation method or the food extraction method. _Science in the science: The agricultural shrinkage includes extraction, separation, concentration, drying and other projects. __, thin and two! A dosage form or a sac-capsule; a food that is convenient for carrying, transporting, and taking, and a treatment for the two kinds of treatments, a red-smelling formula for the composition of the towel-extracted concentrated composition; 1 composition according to the pathology and pharmacological machine The safe dose range is based on the principle of compatibility, specifically for the treatment of female menstrual pain, the third blood. _ type of menstrual pain, special _t grass fresh concentrated composition: Angelica 1~12g, Chuan (10) 5~1〇g, 〇 5~1 〇g, 黄彻~(4) Ginseng 〇34 ΤΙΤΓ 〇'4^159 ' 〇'4^159 ' 〇·4^159 ' ^ g stem white (10)~4.5g, rehmannia root a3~30g, radix rehmanniae 3~3 〇g, Zhenyan 3~ Lou' 〇·2, 炙甘草〇. 2~3g, berberine Q 2~3g, Cork Q 2~9g, 靡2~ II I: complex. 〇2~1〇(四)成; specially designed for the treatment of women with menstrual pain in the third stage of hemorrhagic myoma type menstrual pain and 10% of menstrual pain; 6. Physic_Enriched combination=Second-reduced composition's preparation_Can be used to avoid the condensed condensed lang: It is prepared by the method of water extraction or consumption of wine by the method of scientific music shrinking, using scientific Chinese medicine, shrinking Including extraction, separation, concentration, drying and other engineering obtained medicinal granules, after: into tablets, tablets or capsules; easy to carry, transport, Gu Jian food or medicine. 59 201221135 7. A Chinese herbal formula for treating women with menstrual pain, according to the pathology and pharmacological machine, and the composition of the fine composition of the object; the painful disease is a fine-stage tumor type, and the phase of the grass is specially designed for the treatment of women. 2~12g, Corydalis 2~10g, Guizhi 2 Arita is 9th. Ug peony bark 2~9g, white peony 2~1〇g, heart 2~9g(10)i~1Gg, peach kernel Q9~i2g, achyranthes Qg Wulingling 0.6~8g, ginseng 〇.3~15g, cinnamon g red and 〇 .6 8g, 〇桂〇·3~5g, medicinal 〇·3~10g, 棺 〇 〇 3 ~1〇g, safflower 0.2~6g, Baiding ai~10g, 紫su production hard 3 y square, color 01 ~1〇9, Magnolia 0.1~1〇g, 甘卓〇·ι,, betel nut, 耆 耆~15g, windproof 木, 木香〇, 〇'1^109 ' 〇〇〇5^109 ' 0 01 -39 Axis Detachable Twisting __Extracting Concentrate 8 The Chinese herbal medicine extracting concentrated composition for treating female menstrual diseases as described in claim 7 of the patent scope = the fourth group of formula composition, which can be prepared by decoction or concentrated decoction The agent is used in the preparation of the second method (6) agricultural shrinkage method, a water extraction method, the extraction of the recipe, the scientific study of the two Wei, the extraction, separation, concentration, dry separation of the obtained shaft granules, after reprocessing Tablet, lozenge or capsule dosage form; convenient for carrying, healthy food or medicine. Transport wheel, clothing (four) food, insurance
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CN102688432A (en) * 2012-06-09 2012-09-26 李承平 Tablet for promoting qi flow and soothing liver
CN102824458A (en) * 2012-07-28 2012-12-19 陈双玲 Traditional Chinese medicine for qi deficiency and blood stasis type dysmenorrhea
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Publication number Priority date Publication date Assignee Title
CN102688432A (en) * 2012-06-09 2012-09-26 李承平 Tablet for promoting qi flow and soothing liver
CN102824458A (en) * 2012-07-28 2012-12-19 陈双玲 Traditional Chinese medicine for qi deficiency and blood stasis type dysmenorrhea
CN102940710A (en) * 2012-11-08 2013-02-27 曲庆兰 Traditional Chinese medicine for treatment of uterine prolapse
CN103223034A (en) * 2013-04-15 2013-07-31 滕金红 Traditional Chinese medicine for treating endometriosis
CN103405606A (en) * 2013-08-21 2013-11-27 浙江省中西医结合医院 Traditional Chinese medicine preparation for treating primary dysmenorrhea
TWI477280B (en) * 2014-01-06 2015-03-21 Jian Rung Cheng This cocoa powder with chinese medicinal compound or herbal compound provides treatment, improvement and prevention of female physiological periods and menstrual period syndromes.
EP3429568A1 (en) * 2016-10-31 2019-01-23 Monkam Nitcheu, Guy Faustin Pharmaceutical composition for use in the therapeutic treatment of cancer and complications of cancer
CN110652578A (en) * 2018-06-29 2020-01-07 重庆合钰成贸易有限公司 Female soft care gel and preparation method thereof
CN112798721A (en) * 2021-01-29 2021-05-14 山东明仁福瑞达制药股份有限公司 Fingerprint construction method and application of traditional Chinese medicine preparation for treating cervical spondylosis
CN113855689A (en) * 2021-10-19 2021-12-31 黑龙江中医药大学 Use of astragaloside or its isomer in the preparation of medicine for treating endometriosis

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