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TW201205074A - Apparatus for measuring the blood sugar in a body and the method thereof - Google Patents

Apparatus for measuring the blood sugar in a body and the method thereof Download PDF

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Publication number
TW201205074A
TW201205074A TW99124929A TW99124929A TW201205074A TW 201205074 A TW201205074 A TW 201205074A TW 99124929 A TW99124929 A TW 99124929A TW 99124929 A TW99124929 A TW 99124929A TW 201205074 A TW201205074 A TW 201205074A
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Taiwan
Prior art keywords
blood glucose
microwave signal
glucose concentration
transmission line
signal
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TW99124929A
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Chinese (zh)
Inventor
Cheng-Chi Hu
Huei-Yun Gong
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Cheng-Chi Hu
Huei-Yun Gong
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Priority to TW99124929A priority Critical patent/TW201205074A/en
Publication of TW201205074A publication Critical patent/TW201205074A/en

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

An apparatus and method for measuring a blood sugar concentration in a body, in which the apparatus includes a signal source, a transmission line, a detector, a processing unit, and an output unit. The signal source generates microwave signals. The transmission line contacts the body surface and electrically connects between the signal source and the detector, used for transmitting the microwave signals from the signal source to the detector. The detector detects the microwave signals to obtain a detected result. The processing unit electrically connects between the signal source and the detector, for controlling the frequency of the microwave signals and receiving the detected result to obtain the blood sugar concentration. The output unit electrically connects to the processing unit for outputting the blood sugar concentration.

Description

201205074 六、發明說明: 【發明所屬之技術領域】 特別是一種血糖濃 本發明係有關一種量測裝置及其方法 度量測裝置及其方法。 【先前技術】 糖尿病為目人f紐性疾叙—,且料引紐重 症,如視網膜病變、腎病變、高血壓、下肢血管阻塞等。雖$ 目前仍無糖尿病之根治方法,但可透過飲食 效、 濃度。因此,定期量耻糖濃度尤其重要, 糖濃度資訊,進而有效控制。 然,目前量測血糖濃度均以侵入方式(如紮針)為主,係 透過採樣血液,進而分析血液而得知血糖濃度。透過紮針方 ί測血糖錢,通㈣病人造絲_或排賴,而無法落實 定期檢查’影響病情的監測。或者,當病人紫針時,因心理% 依量測規定紮針,僅紮至皮表附近,再以擠壓方式將^ 液擠出,將影響量測的準確性。 因此,若能提出-種非侵入式的血糖量測方式,而減少病 ^里測血_畏_,勢必對糖尿讀的掌控有所助益,並能 減少糖尿病併發症或致死率。 【發明内容】 有鑑於此,本發明之主要目的在於實現以非侵入方式量測 血糖濃度。 本發明提出一種血糖濃度量測裝置,用以量測待測體之血 糖f度’包含:訊號源,用以產生微波訊號;傳輸線,包含第 二端及第二端’第—端電連接訊號源,傳輸線収傳遞微波訊 唬’並貼附至待測體表面;檢測單元,電連接傳輸線之第二端, 4 201205074 用以檢測第二端之微波訊號,取得檢測結果;運算單元,電連 接訊號源及檢測單元,用以控制訊號源產生微波訊號之頻率, 及接收檢測結果,並運算微波訊號經傳輸線後的能量損耗,據 以換算為血糖濃度值;及輸出單元,電連接運算單元,用以輸 出血糖濃度值。 本發明亦提出一種血糖濃度量測方法,用以量測待測體之 血糖濃度,包含:提供微波訊號;檢測微波訊號部分經待測體 吸收後之能量損耗;換算微波訊號的能量損耗為血糖濃度值; 及輸出血糖濃度值。 有關本發明之較佳實施例及其功效,茲配合圖式說明如 後。 【實施方式】 以下舉出具體實施例以詳細說明本發明之内容,並以圖式 作為輔助說明。說明中提及之符號係參照圖式符號。 請參照第1圖所示,係為本發明第一實施例之方塊圖。一 種血糖濃度量測裝置’用以量測待測體之血糖濃度,包^^訊號 源10、傳輸線20、檢測單元30、運算單元40及輸出單元50。 訊號源10用以產生微波訊號,且可為掃頻訊號源(Sweep signal source) ’可連續產生一區間頻率(如iGHz至5GHz) 之微波訊號。傳輸線20包含第一端21及第二端22,第一端 21電連接訊號源10,用以傳遞微波訊號,並貼附至待測體表 面。檢測單元30電連接傳輸線20之第二端22,用以檢測第 一端22之微波號’取得檢測結果。運算單元4〇電連接訊號 源10及檢測單元30,用以控制訊號源10產生微波訊號之頻 率’及接收檢測結果,並運算微波訊號經傳輸線2〇後的能量 損耗,據以換算為血糖濃度值。輸出單元5〇電連接運算單元 40,用以輸出血糖濃度值。 201205074 於此,傳輸線20可為微帶線(Microstrip iine)、共平面波 導線(Coplanar wave guide)或槽線(slot line)。檢測單元 30 可為功率檢測器’檢測於傳輸線2〇之第二端22的微波訊號之 功率,並傳至運算單元4(^運算單元4〇可比較訊號源1〇產 生之微波訊號及傳輸線20之第二端22的微波訊號之功率,而 得知微波訊號經傳輸線20後的能量損耗。 請參照第2圖所示’係為本發明第一實施例之微波能量損 耗與微波頻率及血糖濃度關係圖。可見,於施以1GHz至5GHz 頻率之微波時,血糖濃度與微波能量損耗成正相關,於2GHz 至3GHz頻段尤佳。因此,可藉由微波能量損耗換算為血糖濃 度。 义請參照第3圖所示,係為本發明第二實施例之方塊圖。除 前揭第一實施例所述外,更可包含保護層6〇,覆蓋於傳輸線 20上,用以貼附至待測體表面,可提高量測裝置之耐用度。 &amp;請參照第4圖所示,係為本發明第三實施例之方塊圖。除 前揭第一實施例所述外,更可包含共振單元7〇,位於傳輸線 20旁’用以吸收部分微波訊號。因共振單元7〇之介電材質, 使微波訊號^共振單元70内形成駐波,而將大部分微波訊號 保留於共振單元70中,加強檢測單元3〇檢測到之微波能量損 耗或造成微波訊號之頻率飄移,以提高微波能量損耗對血糖濃 度之鑑別度。於此’共振單元70可為介電質諧振器(Dieiectric resonator)。 請參照第5圖所示,係為本發明第一實施例之流程圖。一 種土·糖濃度量測方法,包含下列步驟: 步驟S310 :提供微波訊號。於此,由前述第2圖可知, 血糖濃度與微波頻率亦有相關,因此,微波訊號可視情形調整 頻率。 步驟S330 :檢測微波訊號部分經待測體吸收後之能量損 201205074 耗。於此,可將微波訊號接近待測體,因待測體吸收部分的微 波訊號,而造成微波訊號能量損耗’並可透過量測微波訊號之 功率變化,檢測微波訊號的能量損耗。 4… 步驟S350 :換算微波訊號的能量損耗為血糖濃度值。於 此’藉由微波訊號經待測體收所造成的能量損耗,可^推回對 應之血糖濃度值。 步驟S370 :輸出血糖濃度值。於此,可將血糖濃度值輸 出至外部裝置進行運用或於螢幕顯示。 於步驟S330前’更可包含步驟S32〇:吸收部分微波訊號, 用以強化微波訊號的能量損耗。於此,可提供介電質諧振器, 以共振微波訊號’使部分微波訊號保留於介電質諧振器中,加 強步驟S330檢測到之微波訊號之能量損耗或造成微波訊號之 頻率飄移’藉以提高微波能量損耗對血糖濃度之鑑別度。換言 之,透過介電質諧振器,可改變微波訊號之能量損耗及頻率, 且其變化幅度與血糖濃度值相關,因此可結合此二種參數傕拖 算之金糖濃度更為準確。 綜上所述,本發明提出量測血糖濃度之方法及其裝置,可 k供非侵入式的方式量測血糖濃度。 雖然本發明的技術内容已經以較佳實施例揭露如上,然其 並非用以限定本發明,任何熟習此技藝者,在不脫離本發明之 精神所作些許之更動與潤飾,皆應涵蓋於本發明的範疇内,因 此本發明之保護範圍當視後附之申請專利範圍所界定者為準。 【圖式簡單說明】 第1圖為本發明第一實施例之方塊圖。 第2圖為本發明第一實施例之微波能量損耗與微波頻率及血 糖濃度關係圖。 第3圖為本發明第二實施例之方塊圖。 201205074 第4圖為本發明第三實施例之方塊圖。 第5圖為本發明第一實施例之流程圖。 【主要元件符號說明】 10 訊號源 40 運算單元 20 傳輸線 50 輸出單元 21 第一端 60 保護層 22 第二端 70 共振單元 30 檢測單元201205074 VI. Description of the invention: [Technical field to which the invention pertains] In particular, a blood glucose concentration method relates to a measuring device and a method thereof, and a method and a method thereof. [Prior Art] Diabetes is a disease of the eye, and it is expected to be severely ill, such as retinopathy, nephropathy, hypertension, vascular obstruction of the lower extremities. Although there is still no cure for diabetes, it can be through diet and concentration. Therefore, the regular amount of shame concentration is especially important, and the sugar concentration information is effectively controlled. However, the current measurement of blood glucose concentration is mainly based on invasive methods (such as needles), which are obtained by sampling blood and analyzing blood to determine blood glucose concentration. By measuring the blood sugar money through the needle, the patient's silk _ or reliance on the patient's silk can not be implemented regularly to check the monitoring of the disease. Or, when the patient has a purple needle, the needle is stipulated according to the measurement, and only the needle is tied to the vicinity of the skin surface, and then the liquid is squeezed out, which will affect the accuracy of the measurement. Therefore, if you can propose a non-invasive blood glucose measurement method and reduce the blood test, it is bound to help the control of diabetes reading, and can reduce the complications or mortality of diabetes. SUMMARY OF THE INVENTION In view of the above, it is a primary object of the present invention to achieve a non-invasive measurement of blood glucose concentration. The present invention provides a blood glucose concentration measuring device for measuring blood glucose f degree of a test object comprising: a signal source for generating a microwave signal; and a transmission line including a second end and a second end of the first end electrical connection signal The source, the transmission line receives and transmits the microwave signal 并' and is attached to the surface of the object to be tested; the detecting unit is electrically connected to the second end of the transmission line, 4 201205074 is used to detect the microwave signal of the second end, and obtains the detection result; the arithmetic unit, the electrical connection The signal source and the detecting unit are configured to control the frequency at which the signal source generates the microwave signal, and receive the detection result, and calculate the energy loss after the microwave signal is transmitted through the transmission line, thereby converting the blood glucose concentration value; and outputting the unit, electrically connecting the arithmetic unit, Used to output blood glucose concentration values. The invention also provides a blood glucose concentration measuring method for measuring the blood glucose concentration of the sample to be tested, comprising: providing a microwave signal; detecting the energy loss of the microwave signal portion absorbed by the object to be tested; and converting the energy loss of the microwave signal to blood sugar Concentration value; and output blood glucose concentration value. The preferred embodiment of the invention and its efficacy are described in conjunction with the drawings. BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail below with reference to specific embodiments. The symbols mentioned in the description refer to the schema symbols. Referring to Fig. 1, there is shown a block diagram of a first embodiment of the present invention. A blood glucose concentration measuring device </ RTI> is used for measuring the blood glucose concentration of the test object, including the signal source 10, the transmission line 20, the detecting unit 30, the arithmetic unit 40, and the output unit 50. The signal source 10 is used to generate a microwave signal, and the Sweep signal source can continuously generate a microwave signal of an interval frequency (eg, iGHz to 5 GHz). The transmission line 20 includes a first end 21 and a second end 22. The first end 21 is electrically connected to the signal source 10 for transmitting the microwave signal and attached to the surface of the object to be tested. The detecting unit 30 is electrically connected to the second end 22 of the transmission line 20 for detecting the microwave number of the first end 22 to obtain the detection result. The computing unit 4 is electrically connected to the signal source 10 and the detecting unit 30 for controlling the frequency of the microwave signal generated by the signal source 10 and receiving the detection result, and calculating the energy loss of the microwave signal after passing through the transmission line 2, thereby converting the blood glucose concentration into value. The output unit 5 is electrically connected to the arithmetic unit 40 for outputting a blood glucose concentration value. 201205074 Here, the transmission line 20 can be a microstrip line, a Coplanar wave guide, or a slot line. The detecting unit 30 can detect the power of the microwave signal of the second end 22 of the transmission line 2〇 and transmit it to the computing unit 4 (the computing unit 4 can compare the microwave signal and the transmission line 20 generated by the signal source 1). The power of the microwave signal at the second end 22 is used to know the energy loss of the microwave signal after passing through the transmission line 20. Please refer to FIG. 2 as the microwave energy loss and the microwave frequency and blood glucose concentration in the first embodiment of the present invention. It can be seen that when microwaves with a frequency of 1 GHz to 5 GHz are applied, the blood glucose concentration is positively correlated with the microwave energy loss, and is particularly good in the 2 GHz to 3 GHz frequency band. Therefore, the microwave energy loss can be converted into blood glucose concentration. 3 is a block diagram of a second embodiment of the present invention. In addition to the first embodiment, a protective layer 6〇 may be further included on the transmission line 20 for attaching to the object to be tested. The surface can improve the durability of the measuring device. &amp; Please refer to FIG. 4, which is a block diagram of a third embodiment of the present invention. In addition to the first embodiment, the resonance unit 7 may be further included. Hey, in the biography The line 20 is used to absorb part of the microwave signal. Due to the dielectric material of the resonant unit 7〇, a standing wave is formed in the microwave signal resonance unit 70, and most of the microwave signal is retained in the resonance unit 70, and the detection unit 3 is strengthened. 〇 The detected microwave energy loss or the frequency drift of the microwave signal to improve the discrimination of the microwave energy loss to the blood glucose concentration. The 'resonant unit 70 can be a dielectric resonator. Please refer to Figure 5. The present invention is a flow chart of a first embodiment of the present invention. A soil and sugar concentration measuring method comprises the following steps: Step S310: providing a microwave signal. Here, the second figure shows the blood glucose concentration and the microwave frequency. It is also related, therefore, the microwave signal can adjust the frequency according to the situation. Step S330: Detecting the energy loss of the microwave signal part after being absorbed by the object to be tested 201205074. Here, the microwave signal can be approached to the object to be tested, because the absorption part of the object to be tested The microwave signal causes the microwave signal energy loss' and can measure the energy loss of the microwave signal by measuring the power variation of the microwave signal. Step S350: The energy loss of the converted microwave signal is the blood glucose concentration value. In this case, the energy loss caused by the microwave signal passing through the body to be tested can be pushed back to the corresponding blood glucose concentration value. Step S370: The blood glucose concentration value is output. In this case, the blood glucose concentration value can be output to an external device for operation or display on the screen. Before step S330, the method can further include the step S32: absorbing part of the microwave signal to enhance the energy loss of the microwave signal. The dielectric resonator uses the resonant microwave signal to keep part of the microwave signal in the dielectric resonator, and enhances the energy loss of the microwave signal detected in step S330 or causes the frequency of the microwave signal to drift, thereby increasing the microwave energy loss to the blood glucose. The degree of discrimination. In other words, through the dielectric resonator, the energy loss and frequency of the microwave signal can be changed, and the magnitude of the change is related to the blood glucose concentration value. Therefore, the concentration of the gold sugar can be more accurately combined with the two parameters. In summary, the present invention provides a method and apparatus for measuring blood glucose concentration, which can be used to measure blood glucose concentration in a non-invasive manner. Although the technical content of the present invention has been disclosed in the above preferred embodiments, it is not intended to limit the present invention, and any modifications and refinements made by those skilled in the art without departing from the spirit of the present invention are encompassed by the present invention. The scope of protection of the present invention is therefore defined by the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a block diagram showing a first embodiment of the present invention. Fig. 2 is a graph showing the relationship between microwave energy loss, microwave frequency and blood sugar concentration in the first embodiment of the present invention. Figure 3 is a block diagram of a second embodiment of the present invention. 201205074 Figure 4 is a block diagram of a third embodiment of the present invention. Figure 5 is a flow chart of the first embodiment of the present invention. [Main component symbol description] 10 Signal source 40 Operation unit 20 Transmission line 50 Output unit 21 First end 60 Protective layer 22 Second end 70 Resonant unit 30 Detection unit

Claims (1)

201205074 七、申請專利範圍: 1. -種血糖濃度#測裝置,用以量測_待_之錄漠度,包 含: 一訊號源,用以產生一微波訊號; 一傳輸線’包含—第—端及一第二端,該第-端電連接該訊 號源,該傳輸線用以傳遞該微波訊號,並貼附至該待測體表面; 一檢測單元,電連接該傳輸線之該第二端,用以檢測該第二 Φ 端之該微波訊號,取得一檢測結果; 一運算單元,電連接該訊號源及該檢測單元,用以控制該訊 號源產生該微波訊n之頻率,及接收該檢測結果,並運算該微波 訊號經該傳輸線後的能量損耗,據以換算為一血糖漢度值;及 輸出單7C ’電連接該運算單元,用峨出該血糖濃度值。 2·如明求項1之血贿度制裝置,其巾’轉輸線為微帶線、 共平面波導線或槽線。 _ 3· ^求項1之血糖濃度量測裝置,其中,該檢測單元為功率檢 測器。 4. 如#求項丨之血糖濃度量測裝置,更包含—保護層,覆蓋於該 傳輸線上,用以貼附至該待測體表面。 5. 如請求項1之血糖紐量測裝置,其+,該微波訊號之頻率介 於1GHz至5GHz之間。 6. 如4求項1至請求項5中任一項之域濃度量測裝置,更包含 共振單το ’位於該傳輸線旁,用以吸收部分該微波訊號。 201205074 7·如請求項6之血糖濃度量測裝置,其巾,該共振單元為介電質 譜振器。 8. —種血糖濃度量測方法,用以量測一待測體之血糖濃度,包 含: 提供一微波訊號; 檢測該微波訊號部分經該待測體吸收後之能量損耗; 換异該微波訊號的能量損耗為一血糖濃度值;及 輸出該血糖濃度值。 9·如請求項8之血糖濃度量測方法,其中,於檢測該微波訊號部 分經該待測體吸收後之能量損耗之步驟前,更包含··吸收部分 該微波訊號。 10.如請求項8之血糖濃度量測方法,其中,該微波訊號之頻率介 於1GHz至5GHz之間。201205074 VII, the scope of application for patents: 1. - a blood glucose concentration # measuring device, used to measure _ _ _ recording discretion, including: a signal source for generating a microwave signal; a transmission line 'contains - the first end And a second end, the first end is electrically connected to the signal source, the transmission line is used for transmitting the microwave signal, and is attached to the surface of the object to be tested; a detecting unit is electrically connected to the second end of the transmission line, Detecting the microwave signal of the second Φ end to obtain a detection result; an operation unit electrically connecting the signal source and the detection unit for controlling the frequency of the microwave signal n generated by the signal source, and receiving the detection result And calculating the energy loss of the microwave signal after passing through the transmission line, and converting it into a blood sugar Hanting value; and outputting the single 7C' electrically connected to the computing unit to extract the blood glucose concentration value. 2. According to the blood bribe system of the claim 1, the towel's transmission line is a microstrip line, a coplanar waveguide line or a slot line. _ 3· ^ The blood glucose concentration measuring device of claim 1, wherein the detecting unit is a power detector. 4. The blood glucose concentration measuring device of the present invention further comprises a protective layer covering the transmission line for attaching to the surface of the object to be tested. 5. The blood glucose signal measuring device of claim 1, wherein the frequency of the microwave signal is between 1 GHz and 5 GHz. 6. The domain concentration measuring device according to any one of claim 1 to claim 5, further comprising a resonance single το' located adjacent to the transmission line for absorbing a portion of the microwave signal. 201205074. The blood glucose concentration measuring device according to claim 6, wherein the resonance unit is a dielectric spectrum oscillator. 8. A blood glucose concentration measuring method for measuring a blood glucose concentration of a sample to be tested, comprising: providing a microwave signal; detecting an energy loss of the microwave signal portion absorbed by the object to be tested; and changing the microwave signal The energy loss is a blood glucose concentration value; and the blood glucose concentration value is output. 9. The blood glucose concentration measuring method according to claim 8, wherein before the step of detecting the energy loss of the microwave signal portion after being absorbed by the object to be tested, the microwave signal is further included. 10. The blood glucose concentration measuring method of claim 8, wherein the frequency of the microwave signal is between 1 GHz and 5 GHz.
TW99124929A 2010-07-28 2010-07-28 Apparatus for measuring the blood sugar in a body and the method thereof TW201205074A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI595970B (en) * 2012-08-28 2017-08-21 荏原製作所股份有限公司 Elastic film and substrate holding device
WO2025175650A1 (en) * 2024-02-20 2025-08-28 臻晟极点(上海)医疗科技有限公司 Wearable noninvasive microwave glucometer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI595970B (en) * 2012-08-28 2017-08-21 荏原製作所股份有限公司 Elastic film and substrate holding device
WO2025175650A1 (en) * 2024-02-20 2025-08-28 臻晟极点(上海)医疗科技有限公司 Wearable noninvasive microwave glucometer

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