TW201113061A - Manually-driven intravenous injection medicine calculation system and method applying medicine kinetics model - Google Patents

Abstract

The present invention provides a manually-driven intravenous injection medicine calculation system and method applying medicine kinetics model. A user interface is used to provide a drug and medicine kinetics model, a setting of basic information for patients, a setting of dosage, a setting of automatically updating records of medical use, a setting of lower limit of concentration (Ce) at acting position, a setting of alarm from Ce to a peak value, and a function of editing records of medical use. The above-mentioned data, after being stored in a storage unit, is processed by a processing unit according to the entered settings and records of medical use for obtaining a time function of concentration (Ce) at acting position by applying the medical kinetics model. This function can be used to dynamically display the following information on a display unit: amount of medicine used, real time Ce value, Ce peak value, time elapsed in reaching the peak value of Ce, and time required for the Ce to drop to a lower limit. Meanwhile, a timing unit and a sound effect and lamp warning unit can be used to remind users on a time when the medicine reaches an optimum effect or an additional amount of medicine is required when the medicinal effect is insufficient. The users can implement multiple dispense of medicine according to clinical needs, thereby achieving the objectives of safety, accurately controlling and providing suitable dosages for patients.

Description

201113061 VI. Description of the Invention: [Technical Field] The present invention relates to a system and method for calculating a hand-injected intravenous drug using a pharmacokinetic model, which uses a pharmacokinetic model of a multi-chamber plus action site to calculate a patient's site of action The concentration of the drug is convenient for the user to control the dosage of the drug and to master the reaction time of the drug. u [Previous technique] Taking anesthesia as an example, in the process of guiding anesthesia or short-term sedation, intravenous anesthesia is often needed, although the pharmacokinetic model has been developed - but it has not been applied to hand-pushing drugs. The product, ": the experience of the clinician may be subject to error. There is currently no method for pharmacokinetic models and analysis of the parameters of a large number of patients to obtain model parameters in a reliable and convenient way to estimate the push after administration At the site of action, the degree changes. This method allows the physician to precisely control the amount of hand-pushing y. Anesthesia is safer, safer, and improve the efficiency of the surgical team. Application of pharmacokinetic models and information to existing products. Apply it to the = pump, this system will be applied to the situation of repeated hand-push injection, 'especially suitable for guiding anesthesia, can quickly and smoothly guide the anesthesia. Because there is a need to set the needle Tube pump, even connection ~ tube: source and other steps can start, if it is used to guide the hemp ": set up,: continue to be too complicated, difficult to accept aging. M hands It can be seen that the above-mentioned items are still missing, which is urgent and needs to be improved.疋σ之之. In addition, the inventor of the present invention improved and innovated in view of the shortcomings of the above-mentioned conventional anesthesia methods, and after years of research, the application of the pharmacokinetic model was completed. [Invention] The main purpose of the present invention is to enable a hand-push intravenously to achieve a safe and effective drug concentration range that is simple, fast and smooth. The secondary purpose of the present invention is to derive the function of the individual by using the user interface to obtain the selected drug and the kinetic model of the music, the basic data of the patient, the dose setting, and the statistical results of the pharmacokinetics of the drug. A two-injection drug calculation system and method for applying the pharmacokinetic model to achieve the above object is to provide a drug and model selection through a user interface, and input basic information of a patient (eg, gender, age, body 'ancient' = Weight, etc., dose setting (formulation concentration, dose per dose), and & reach = s not set, edit the medication record, (4) the new drug-related parameters are stored in the material unit, and then the processing unit will = Calculate the time function of the concentration of the site of action using the pharmacokinetic model, ^(1) 1 1% of the site, OK? The current function c will be displayed in the manufacturer interface display unit, the time of the peak, the time of reaching the Ce peak,

The time required for Ce to fall to the bottom limit, etc., one warning unit, I am 10 o'clock early and a sound effect and light number is strict - raw: ##, when text, graphic display and sound effect, user concentration is in use The safety of the demand is as follows: the second person's second _ injection of the drug 'users can see the clinical needs, and the automatic new 増 増 & & ^ ^ ^ ^ ^ ^ ^ 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 汉 到达 到达 到达 到达Another H; 1, to achieve convenient and effective control of the patient to administer and record, or modify the 更 user can be based on the condition of the surgery 'suggested, 4 氐 专 limit specific settings, or to correct the patient's basic. Fully and accurately grasp and provide the dosage suitable for the patient [Embodiment] Γ, Figure - 'Figure 2 and Figure 3, the present invention includes: = unit 2, the storage unit 2 provides various setting parameters Storage. 201113061 - Select drug and model module 1〇, the drug of choice A variety of drug and pharmacokinetic models for users to choose. , and the base setting module 11 'provides the user to input the patient's basic ^ * age, body, weight, gender (please refer to Figure 2, the remaining results will be stored in the storage unit 2. ' 1 The dose setting module 12 provides the transfer number including the formula concentration and the dosage amount of each dose. The dose parameter is stored in the storage unit 2, and the reference figure is shown in the figure--will automatically add the medication record setting module 丨3 The automatic mode is used for new 妗< (10) Added technical music reading, the setting result will be stored in the storage unit 2 & bottom limit setting module 14, the bottom limit, the setting result will be stored in the storage action part _

The peak warning setting module 15 is reached, and the provider determines whether the prompt is issued by the sound effect and the light warning unit 6 in the Q, and the result will be stored in the storage unit 2. The treatment of single 兀3, according to the application of drug dynamics ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ ^ music dynamics model with storage ^ to add effect. Η Immediately glare the external 皙 π π 1~ stay A, morning) change function, and the unit / medium plus = data and graphics production single ^ 5 rounds of the graphic by the display, the display unit 4 can be any - A display device. After the calculation result of the processing unit 3 is started, the timing of the process is counted down, and the arrival time of the bottom limit is counted down, and the month 4 is not displayed 70 4 with the graphic creation unit 5. A display unit 4 receives Lu Li s. The process of "down": Instant::::=Results and timing... The calculation result of the unit over 5 passes 3 _ f , , 'The curve of the production part (Ce) function, and c 5 201113061 Time note see Figure 6 The instant display is displayed on the display device. An audio effect and light warning unit 6, when the leaf is processed, the processing unit 3 will drive the sound effect and the light alarm:: and the light number. Unit 7, direct each slave & alpha warning sound and light signal prompts the user to administer drugs;: use yuan 6 hair: TM-pen medication record; 10,000-make = = this morning delete or correct the medication record. Figure 4 shows the drug dynamics of the three-chamber plus action site. = Description: When the dosing record is updated, the treatment order (4) will change the function of the concentration of the site (6) to calculate G ^ to f. Ce peak time and (; 6 time to the bottom limit, and the immediate value, the following illustrates the method of the invention: First, according to the results of the group pharmacokinetics can be from the patient parameters, body, weight, The age and other data to calculate the volume of each chamber, the drug 3 rate constant, The metabolic rate constant of the substance, when administered by hand push, is transferred from the middle (four) position (blood aggregation (four) to the fast-balanced part (muscle, month (6), k + balance (fat, etc. chest, action site (such as brain: The substance and metabolic excretion sites (the liver, the kidney, etc. represent the volume of each cavity to the volume) and the drug exchange rate constants between the chambers are: the long-term 'drug metabolic rate constant is ', the clearance rate of the action site* is U and each time the drug is administered | Ce's peak time is required. The above parameters can be calculated from the statistical results of population pharmacokinetics. Let A, the heart be the three solutions of the following polynomial: + M31 + Mu + W21 + M| 2) X also _^12 + h +1 + ~) = After the mother-in-law pushes the drug once, the Ce function can be expressed as:

Ce{t)= Bolus, x (Z[e~^ + + z^tl) + 201113061 where 丨 丨 = moment of bolus, βθ/MS 1 = bolus dose, = keQ (moxibustion 21 _ 乂i) fei — Λ) K〇~K (^2 -^)^1 Ζ2 == - ^e0 (^21 "^-2X^31 ~^) ^eO ~ (^2 ~ Λ Χ^2 ~ ^ )^1 Ζ3 = - ke〇(^21 ~ ^3X^31 ~^) ^eO ~ 4 =~(WZ3) Since the concentration function has additiveity, the concentration function is added after the lapse of the bolus:

CeW = Σ β〇Η X (Z, work-° + z2e + z3e, i) + z ;_1 4 ) where ί g ίη because βθ/MSi, ii are known (from the drug record) , so the simplification is:

Ce(i)=life, + + know, + heart

Ce'(i) = - AjS3e~A3t - ke〇S4e~ke〇t where Ji, 汐2, heart, 54 is a constant real number, and Ce is a derivative of Ce.

Then, the Ce peak (Ma; cCe) and the Ce peak Umax) were obtained by a binary approximation method. Because Ce, where Ce has a peak at 0, the left of Ce' > 0, and the right of ce' < 0 ', the imax can be obtained by the binary approximation method. The algorithm is as follows: left = now right = now + ί_ Do while right-left >1 //If the left and right boundaries are more than i seconds apart mid = (left + right)/2 // then take the midpoint test if Ce, (mid) < 0 then // if the midpoint Right imax right = mid " then the midpoint is the new right border else // if the midpoint is not right imax left = mid " then the midpoint is the new left border 201113061 // repeat the steps above Until the left and right boundaries are less than 1 second apart tmax = mid // then the last midpoint is taken as the approach value of imax

MaxCe = Ce (tmax) // MaxCe occurs at imax and then uses the binary approximation method to find the time when Ce falls to the bottom limit. The example here is based on 24 hours. If the time is more than one day, the algorithm returns 24 The hour after the hour is taken as the moment when Ce falls to the bottom limit. Among them, LSCe is the user-defined Ce bottom limit, which can be adjusted according to clinical needs. Since Ce is decremented later, iiB can be obtained by the following algorithm: left = tmax " After tmax, Ce(e)=LBCe right = left + 24_hours do while right - left > 1 //If the left and right boundaries are more than 1 second apart mid = (left + right )/2 " then take the midpoint check bee if O(mid) < ZJCe then / / If the midpoint is right = mid " then the midpoint is the new right border else // the right _ point is not the right of b left = mid " then the midpoint is the new left border // repeat Steps until the left and right boundaries are less than 1 second apart iiB = mid // then the nearest midpoint is the approach value. Please refer to Figure 5 and Figure 6 for an application rate dynamics model of the present invention. Flow chart of the calculation method of the hand push intravenous medicament: Step 1: The system receives the selected medicine and model module, the patient basic data setting module, the dose setting module, the automatic new medication record setting module, and the Ce bottom setting. Module, Ce reach the peak warning setting module input and medication record Dosing of recording data editing unit 501. Step 2: The storage unit stores various setting parameters 502. 201113061 Step 3: The processing unit 蚪 has a relationship with the Q peak (Mfl; cCe), the function and its derivative function (1) 503. When the value time ~ falls to the bottom limit, ?, :, and so on, the fourth step is calculated. (1), the total amount of the drug, ～αχ iLS and other data are displayed in the g indicating unit 504 β is not early or after the graphic material element is displayed in the visual step 2::: Tsui Yuan and the graphic production unit according to step 4 Data £^ and ~ will set modules with different peak strikes when arriving

Feng Wei. Notify the user 505 with the sound and the light. Step 6. If the automatic new investment & drop to the bottom limit (% clear), the self-group is set to on, and the user listens to the new-pen medication record. In this mode, _ ^ " 曰 or see the light will be followed by the drug, and the need to re-record the music record 506; if the automatic new machine "public.,," and then enter the vote seven. If it is set to not add, then the step end key is overwritten; so that: ― step by step: two bundles _ shape, "! The user presses the end key: break" and the display data is not shown in the figure. Shown, for the hair injection of the hair (four) mu kind of psychodynamic model of the hands of the schematic /, the top ten different systems and methods of the graphics production of the single output of the graphic agent, first break the i-degree limit tender). Start injection

LfiCe time gate A, ' Then Ce will be decremented, down to the time of ~1; the user hears the sound and the light warning, and adds the medication record; the right 杈 杈 value 2), arrived Γ to the new The peak...peak_between and the time it falls to the time is repeated until the user stops using it; the graphic creation unit ^201113061 constantly updates the graphic until the execution ends. The system can be stored in a computer readable and executable to complete the present invention. ° Recorded media, when the computer is loaded into the program The system can also be integrated into the computer under the bed, or the anesthesia recording software, the consultation, anesthesia machine, mobile device, and the line can complete the present invention. Tian Shu Instrument is loaded into this program and implements the multi-chamber with the pharmacokinetics of the invention and other conventional technologies. It has the following advantages: Group pharmacokinetic inference of each _ ° 7 site drug model, based on the record calculation has been administered When the quantity is I: the time value of the movement value and the peak value of G is reached, and the degree (9) value and the Q peak are displayed to the user for reference at any time. The time required to fall to the bottom limit, and 2·::Γ and the light warning unit, when the concentration of the active part falls to the heart=limit, the user will be reminded to add the medicine to the peak of the ce by means of the ringing and the warning of the light. Warnings 'Prompt when to achieve the desired effect can enter the purpose of the skill (for example, start surgery). DETAILED DESCRIPTION OF THE INVENTION The detailed description of the present invention is directed to one of the possible embodiments of the present invention and is not intended to limit the scope of the invention, which is not the scope of the invention. Or the change 'should be included in the Al of the case. The case is not only innovative in terms of technical thinking, but also more customary, and the product enhances the above-mentioned multiple functions. It should fully comply with the statutory invention patent requirements of novelty and progress. 'Properly submit an application according to law', please ask your office to approve the application for this invention patent, in order to invent invention, to the sense of virtue. χ [Simple diagram of the diagram] Figure 1 is a structural diagram of a drug calculation system and method for a hand-pushing intravenous injection 201113061 using a pharmacokinetic model; Figure 2 is a hand-pharmaceutical calculation system using a pharmacokinetic model of the present invention. And a method for inputting a user interface of the user interface; / FIG. 3 is a schematic diagram of a user interface display unit of the system for calculating a static drug calculation system and method using the pharmacokinetic model, and the main image of the rw is the present invention. A three-chamber injection model for pharmacokinetics of a drug calculation system and method using a pharmacokinetic model; P-position pharmacokinetic map five. A schematic diagram of a graphical representation of a hand-pushing, agent-calculating system and method using a pharmacokinetic model; I-injecting drug Figure 6 is a hand of a pharmacokinetic model of the present invention. Flow chart of the system steps of the drug calculation system and method [Main component symbol description] 10 Select drug and model module 11 Patient basic data setting module 12 Dose setting module 13 Automatically add medication record setting module 14 Ce The bottom limit setting module 15 Ce reaches the peak warning setting module 2 The storage unit 3 The processing unit 31 The timing unit 4 The display unit 5 The graphic creation unit 6 The sound effect and the light warning unit 7 The medicine record editing unit

Claims (1)

201113061 VII. Patent application scope: A hand-injection intravenous drug calculation system using a pharmacokinetic model, which includes: - selection of drugs and models, which provide a variety of drug and pharmacokinetic models for users to choose; - patients The basic data setting module 'is providing the user with input of the patient basic data parameters; - Dosage set (4), which provides the user to set the dosage and formula concentration for each dose; it provides the choice whether to open the concentration of the action site from the system for the adjustment of the concentration of the action site. The function of the bottom limit of the action part sets the function of the bottom limit of the module; - the concentration of the action part reaches the peak invitation # 咬, but s does not s and 疋杈 group, which is used to select whether to turn on the sound effect and the light warning unit; = storage unit, which stores the above parameters for the processing unit to carry out - the element, the system, the application of pharmacokinetic three-chamber plus action model 'with the storage unit parameter setting and the drug record calculation 4 The part concentration function and the real-time data 'and display the data at any time and at any time according to the projection-recording editing unit, display the medicine on the display unit; and the music-display unit, which is displayed by the processing unit to calculate the instant production unit Graphic; /, 12 201113061 A time is early, which is counted down by countdown, showing the time required to reach the peak concentration and the concentration of the active part is reduced. Sound effect and light warning on arrival; "Time" and - sound and light warning unit, when the timing reaches the bottom limit, 'notify the user to manually push the medicine, when the effect reaches the peak value = the notification can be notified Start; Recording music green editing unit 'It is used to add or delete the drug registration record 2.=Please refer to the patent scope of the first paragraph - the application of pharmacokinetic model of the hand-injection intravenous drug calculation system, group H 7 A. , Y ^ The basic data set the model I 3 . Age, height, weight and gender or other group pharmacokinetics may use the parameters. ', I such as Shen. Monthly patent dry circumference, item 1 A pharmaceutical calculation system using a pharmacokinetic model, wherein the dosage setting of the dose setting module further includes the concentration of the administration formula and the amount of each administration. 4 ίΐ: An application of the drug power described in the first paragraph of the patent Learning model = intravenous drug calculation system 'where the automatic new drug registration record is set two;: the automatic record setting can be based on the demand, in the case of intensive drug administration, the sweat selection system hears warning Immediately after the injection of the drug, the system will automatically record the new music in the dosage record according to the amount of under-administration. 5·如申: Patent is a hand-pushing application of the pharmacokinetic model described in the article! The intravenous/primary drug calculation system, wherein the administration record editing unit includes the functions of adding, deleting, and correcting the drug administration record. 13 201113061 6. As described in the patent application scope 1 main item 4, the hand of the pharmacokinetic model Push intravenous injection calculation system, one effect and light warning list two =: ? The concentration limit of the action part will increase the concentration of the warning sound and the light number: and always the main view can be easily grasped without unit The hand-injection intravenous drug calculation system using the pharmacokinetic model described in the patent application, the application of the pharmacokinetic model, wherein the current data calculated by the processing unit includes the current concentration of the active site, the total dose of the drug, Data on the peak concentration of the action site, the concentration limit of the site of action, and the time of arrival, and recalculate the above data as the user modifies the drug record. A hand-injection intravenous drug calculation system using a pharmacokinetic model according to the above, wherein the display unit displays (4) the data includes the current concentration of the active site, the total dose of the drug, the peak concentration of the site of action and the peak time of arrival, and the site of action. The concentration is reduced to the bottom time and other data, and is recalculated and displayed according to the update of the drug administration record. 9. A hand-injection intravenous drug calculation system using a pharmacokinetic model as described in Patent Application No. W, wherein The display unit can display data on a mobile device such as a monitor, a screen, a computer, a mobile phone or a computer. The calculation method of the hand-injected intravenous medicament of the (four) material dynamics model includes: Step-: The system receives the medicine and the medicine Dynamic model selection, patient basic data setting module, dose setting module, automatic new drug registration setting module, action site concentration threshold setting module or action site concentration reaching the peak warning setting module Dosing record of the drug record editing unit 201113061 Record; Step storage form The unit stores various setting parameters; Step 3: The processing unit calculates the peak value (M(10)), the coefficient of Ce reaching the peak concentration function, the number and Ce (ί〇); the interval between % (imax) and Ce falls to the bottom time step 4 : According to step three 舛苜 2 ^. The concentration of the immediate action site, the peak of the concentration in the donor site, the peak concentration of the site, the music ~ m ^ , the time of the peak concentration of the action site and the time when the temperature falls to the bottom limit, etc., etc., are displayed in the display unit or After the graphic production unit is displayed on the display unit. The page Ding Zaofan = display unit and graphic production unit according to the data of step 4 and the concentration of the action part reaches the peak warning setting module to reach the peak of the action part or the concentration drop of the action part The bottom limit is notified to the user with different warning sounds and lights; the meeting/sequence, right automatic new drug dosing record is set to be on and the 4-digit spread has been applied (4) to the bottom limit is automatically added - pen administration record If it is off, proceed to step 7; Step 7: If the user presses the end button, the program ends. If the button is not pressed, the step is repeated 丄π# '° //, and the data is continuously calculated and displayed. With the graphic 'until the user presses the end key. 11. The computer can read the recording medium in the private storage system. When the computer loads the program and executes it, the system of patent application scope i can be completed. 12. The computer can read the recording medium, and when the computer loads the program and binds it, the method of applying for the patent scope can be completed.