[go: up one dir, main page]

TW201116312A - Medicament delivery device - Google Patents

Medicament delivery device Download PDF

Info

Publication number
TW201116312A
TW201116312A TW98138011A TW98138011A TW201116312A TW 201116312 A TW201116312 A TW 201116312A TW 98138011 A TW98138011 A TW 98138011A TW 98138011 A TW98138011 A TW 98138011A TW 201116312 A TW201116312 A TW 201116312A
Authority
TW
Taiwan
Prior art keywords
outer casing
plunger rod
proximal
container
spring
Prior art date
Application number
TW98138011A
Other languages
Chinese (zh)
Other versions
TWI415643B (en
Inventor
Martin Karlsson
Original Assignee
Shl Group Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shl Group Ab filed Critical Shl Group Ab
Priority to TW98138011A priority Critical patent/TWI415643B/en
Publication of TW201116312A publication Critical patent/TW201116312A/en
Application granted granted Critical
Publication of TWI415643B publication Critical patent/TWI415643B/en

Links

Landscapes

  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

The present invention relates to a medicament delivery device comprising a distal housing part (12); a proximal housing part (10) into which a multi-chamber medicament container (14) is arranged and wherein said proximal housing part is arranged to be movable in relation to said distal housing part for mixing at least two substances arranged inside said container; a plunger rod (32) arranged to act on a distal stopper (34) in said medicament container, wherein a relative movement of said housing parts (10, 12) towards each other forces said distal stopper against the plunger rod in a proximal direction for mixing at least two substances arranged inside said container; a drive force unit (58, 74, 76, 78) capable of forcing said plunger rod (32) in the proximal direction for subsequent delivery of medicament from said medicament container; an activation member (80) slidably arranged through said distal housing part and releasibly connected to the drive force unit; wherein said device further comprises a guide shell (24) one-way rotatable arranged in said distal housing part, wherein said guide shell is provided with threads (22) arranged to cooperate with corresponding threads (20) on said proximal housing, and wherein said guide shell and said plunger rod are arranged with guide members such that they are rotationally locked but slidable in relation to each other.

Description

201116312 四、 指定代表圖: (一) 本案指定代表圖為:第(一)圖。 (二) 本代表圖之元件符號簡單說明: ίο 近端外殼部 12 末端外殼部 14 藥物容器 16 頸部 18 操作構件 24 導流桶 32 柱塞桿 46 鎖件 58 驅動螺帽 64 環狀向近端壁架 74 驅動構件 76 劑量設定紐 78 扭轉驅動彈簧 80 啟動構件 82 環狀構件 86 回位彈簧 五、 本案若有化學式時,請揭示最能顯示發明特徵的化學式: 六、發明說明: 【發明所屬之技術領域】 本發明係關於一藥物輸送裝置,特別是能夠處 理多室藥物容器的可重複使用裝置。 201116312 【先前技術】 内的:多藥物輸送裝置,且藥物置於容- 在此藥物在被輸送時接觸到壓力。一,且 痩長管狀隔室有-瓶塞位於隔室内一:見;二十;-構件附於隔室另一端,如:、,t於 ^ 輪送 輸送藥物給病人的構件。”、、噴嘴等等能夠 由』送大量藥物,瓶塞接觸到壓力,如.蕤 由柱塞柃推入隔室,可藉由手指以 % ΐΐΐϊί針筒),或是藉由壓力裝置如 吊被用於自動或半自動注射器中。 簧, 合作許藉多^藥 這非常適合用於抛=藥時物螺因帽= 最前面的位置時,藥物容器變Ϊ 置在使用螺咬柱重喊用的藥物輸送裝 生;S柱料時’會因需轉回原來位置而產 大部分使用者不喜歡此種操作方式,日 柱塞桿要移回多少距離而操作鈣 士確疋 不允許柱塞桿返ΐ 錢•相關於輸送的機制 '者夕至藥物容器越來越受歡迎,_此Μ你 一起味方式喃合。當兩外殼部旋轉在 塞,稭此乾燥狀藥物與液狀藥物混: 201116312 裝ί被鎖後始可設定和輸送劑量 用於多種以:;個=咖7/丨讀的裝置非 【發明内容】 送構i發;! ί ί 5 ”為提供可多次使用的藥物輸 器。此夠以間早和可靠的方法處理多室藥物容 發明專利範圍獨立項的特徵來完成。本 :。月更佳的實施方式成為此專利範圍附屬項的: 妒置,月ϊ主要觀點’其特徵在於藥物輸送 裒,係包括一末端外殼部;一近端一夕 於其内’且在此該近端外殼部可相對二 部移動,以混合該容器内的至少兩物質: ^杯作用於該藥物容器内的末端瓶塞,藉此該 夕卜二:卩=彼此的相對移動迫使該末端瓶塞‘ 杯向近端移動,以混合該容器内的至少兩物^柱^ 驅動力組件能夠迫使該柱塞桿向近端移動,以隨之 從該藥物&器輸送藥⑯;一啟動構件 ^ 該末端外殼部,且可鬆開地連接於該驅==過 在f該裝置又包括一導流桶,可單向旋轉於該末端 :目U蟫it導流桶備有螺紋’與該近端外殼上 相應之螺、,文&作,且在此該導流桶和該柱塞桿備 導引構件以便旋轉地鎖住,但可相對地滑動。 根據本發明另一觀點,導流桶備有縱向延伸棘 輪於其末端外圓周面,在此該棘輪與末端外殼部上 彈性舌狀t的壁架合作,且在此棘輪和壁架相接, 以致導流管只可相對於末端外殼部單向旋轉。 根據本發明另一觀點,裝置包括一近端外殼部 201116312 接於末端外殼部,在此當外殼部在物f混人 ί!!?一特定相對位置時,該鎖件的鎖裝置與該i 卷施嫒部ΐ相應的鎖件嚙合,且在此當藥物i ^被 丄近= ϊ = ,件被啟動來鬆開該鎖裝置間 也使;導流桶;;,= 2對移動時 連接於二第二端 u媒動彈簧被鎖於拉縮狀態,且當j啟 1』2 Ϊ,該驅動螺帽被鬆開且因此該驅動彈簧# =狀態被鬆開’藉此該柱塞桿向近端移= 較佳的該驅動彈簧構件為一扭轉彈簧。 替換=Γ;;優!於容器被 殼部的互動,當近端二 近=卜 m刀始位置,藉此裝置準備好 2 需巧外移動柱塞桿’便利了褒置的操j物 制旦除此^外,根據本發明之裝置,能夠輸送許夕 定鈕也可做為驅動彈簧的張緊器:ί u裝置在使用前不需要讓驅動彈簧處於預先拉縮 附圖些和其他優勢’從以下詳細說明和 201116312 【實施方式】 在目前的應用中,末 是構件在注射時雜#田ι = &思知樂物輸送裝置或 侧,則意指荜2 = 3的那端。相同地,近 者最近的那端 裝置或疋構件在注射時離使用 殼部10® ^ ί = 輸送裝置包括一近端外 钟蚪占故文好末鳊外双°卩I2。很合理地,外殼可祜 i物二他樣式。近端外殼部被用做藥物容器 ”部:相對於該末端外殼部移動ί;二容 附於其上。再者,U射針、吹嘴、喷嘴等等) 功能描述如下者並且Hi有兩操作構件18,其 裝置又包括一套狀mt”卜面有螺紋2〇。 單一方向;— ΐ狀構件,自此稱為導流桶24, 紋2〇與相應的螺紋22人=近知外设部之螺 内面上。導产桶94 4 /作(圖b),位於套狀構件 通道28(圖二此中H端=一端牆26有-中心 放射狀向内突起。柱夷有導流構件30如 其備有相應料流構Γ且 3〇合入,以裎徂am I 縱向溝槽33可讓突起 間。柱塞桿St 4 IS,^ 五a)。一近端匆谷器内的末端瓶塞34接觸(圖 ) 近化瓶塞35位於藥物容器内,因屮报忐雨 至36、38於容器14内,一 盗内因此形成兩 乾燥形式之藥物),另一室38心第-物質(如: 狀的稀釋物)(圖五a)。該外質(如:液 使該末端瓶塞倚著桂夷桿 12相對地移動 器内的至少兩物質 干向近知移動’以混合該容 201116312 導流桶24備有一縱向延伸棘輪4〇於末端圓周 外面上(圖二)’在此該棘輪4〇與末端外殼部12上 彈性舌β狀物42的壁架44合作,且在此棘輪和壁架 4=使得導流桶只能相對於該末端外殼部以同一方向 方疋轉(圖五a)。再者,一鎖件46(圖3)被設計為一環 件48備有兩按鈕狀構件50位於環狀構件48的 直徑兩端。兩按鈕狀構件5〇穿過末端外殼部12上 徑通道52而突出(圖二)。再者,環狀構件48 鎖件54(如直徑兩端溝槽)與相應之鎖件5 外殼部外面上兩肋柱)嚙合(圖三)。混合後當外 ίί2達厂Ϊ定相對位置時,且在此當藥物容器被 近端外殼部鎖件被啟動來鬆開該鎖件54、 對移動該外殼部10、12互相倚著相 動、二轉该導^桶時,藉此該柱塞桿向末端移 出。初σ位置,且近端外殼部從末端外殼部被旋 柱塞Ξί動地3力於Ϊ末端外殼部内且與 =的㈣地通過末料殼部圓周 敘述如下/可鬆開地連接於驅動力組件,將 驅動力组件包括一驅動螺帽 桿32交織嚙合,且可_m58 ’螺帽與該柱塞 敘述如下;一手動極你^接於該啟動構件,將 狀物72可#彡Η祕1Θ拉縮裝置包括彈性鎖舌 彈箬拉縮梦地連接於該螺帽的棘輪7〇,以使今 ;拉縮裝置相對於該螺帽只能單 h 置和-第二端連接於末=簧拉縮裝 縮裝置被操作時,該驅動彈dm該彈簧拉 坪黃被鎖住於拉縮狀態, 201116312 且:邊啟動構件被操做時,該驅動螺帽被鬆開且因 此該驅動彈簧從拉縮狀態被鬆開,藉此該柱塞桿向 近端方向移動以輸送藥物。 ° 枝塞桿32位於驅動螺帽58内,驅動螺帽58内 I備有螺紋60(圖二),與柱塞桿32外面的螺紋62 :作。驅動螺帽58又備有一環狀向近端壁架64 許多齒狀物66環繞於該壁架,其功能將敘述如下。 =動螺帽58之末端備有一環狀部68,環狀物之 圓周面備有縱向停止壁架70。 手動操作彈簧拉縮裝置包括一普通管狀驅動構 4和一劑量設定鈕76。驅動螺帽的止 ,彈性臂72合作,位於普通管狀驅動構件74^ 。驅動構件74末端經由末端外殼部末端突出 二丨丨里β又疋紐76附著處,以旋轉該驅動構件。 槿株壁架70和彈性臂72的合作使得驅動 7〇 / # 72 /月過jT止壁架70。另一方向,彈性臂 2鳊點鄰接停止壁架7〇,因此鎖住旋轉。 (為-扭轉驅動彈簧)同軸地位於驅動n 端Λ於驅動構件74 ”二端附於裝置的ί 疋邛(如.末端外殼部12)。 97 u 二劑量藉由使用彈簣拉縮裝置來設定,所 量藉由相同的增量刻度來達到。- 一預設刻度,預設刻度相當iff里:又疋紐76 每-增量都需額外再順時針旋㊁二J亡201116312 IV. Designation of the representative representative: (1) The representative representative of the case is: (1). (b) The symbol of the representative figure is briefly described as follows: ίο proximal end housing portion 12 end outer casing portion 14 drug container 16 neck 18 operating member 24 guide barrel 32 plunger rod 46 lock member 58 drive nut 64 annular proximal End wall bracket 74 drive member 76 dose setting button 78 torsion drive spring 80 start member 82 ring member 86 return spring 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: 6. Invention: [Invention TECHNICAL FIELD The present invention relates to a drug delivery device, particularly a reusable device capable of handling a multi-compartment drug container. 201116312 [Prior Art] Within: a multi-drug delivery device, and the drug is placed in a volume - where the drug is exposed to pressure while being delivered. First, and the long tubular compartment has a cork in the compartment: see; twenty; - the component is attached to the other end of the compartment, such as:,, t is the component that delivers the drug to the patient. ", nozzles, etc. can send a large amount of drugs, the stopper is exposed to pressure, such as: pushing the plunger into the compartment, by means of a finger with a % 针 针 syringe, or by a pressure device such as a crane It is used in automatic or semi-automatic syringes. Spring, cooperation and borrowing more medicines. This is very suitable for use in throwing medicines. When the first position is used, the medicine container is changed. The drug delivery is carried out; when the S-column is used, it will be returned to the original position and most of the users do not like this operation mode. How many distances should the plunger rod be moved back? The return of the rod money • related to the mechanism of delivery 'the eve of the drug container is becoming more and more popular, _ this Μ you savour the way together. When the two outer shells are rotating in the plug, the dry drug is mixed with the liquid drug : 201116312 After the ί is locked, the dose can be set and delivered for a variety of:: = = coffee 7 / reading device is not [invention content] send i hair;! ί ί 5 " to provide reusable Drug delivery. This is accomplished by an early and reliable method of handling the characteristics of the multi-chamber drug patents. Ben :. A better monthly implementation is a subsidiary of this patent: The main point of view is that the drug delivery sputum includes an end shell portion; a proximal end is inside it and The end outer casing portion is movable relative to the two portions to mix at least two substances in the container: the cup acts on the end stopper in the drug container, whereby the relative movement of each other forces the end stopper The cup moves proximally to mix at least two of the contents of the container. The driving force assembly can force the plunger rod to move proximally to subsequently deliver the drug from the drug &16; activating member ^ The end housing portion is releasably connected to the drive. The device includes a diversion barrel that can be unidirectionally rotated at the end: the U蟫it diversion barrel is provided with a thread Corresponding screws on the end housing, and the guide barrel and the plunger rod guide member are rotatably locked, but are slidable relative to each other. According to another aspect of the present invention, the guide bucket is provided with a longitudinally extending ratchet on its outer circumferential surface, where the ratchet cooperates with the ledge of the resilient tongue t on the end outer casing portion, and the ratchet and the ledge are connected thereto. The guide tube can only be unidirectionally rotated relative to the end housing portion. According to another aspect of the present invention, the device includes a proximal end housing portion 201116312 attached to the end housing portion, wherein when the housing portion is in a specific relative position, the locking device of the locking member and the i The corresponding locking member is engaged, and when the medicine i ^ is approached = ϊ = , the member is activated to release the lock device; the diversion bucket;;, = 2 pairs are connected during movement At the second end of the second, the u-media spring is locked in the contracted state, and when the lever is opened, the drive nut is released and thus the drive spring #= state is released 'by the plunger rod Moving to the proximal end = Preferably the drive spring member is a torsion spring. Replace = Γ;; excellent! In the container by the shell part of the interaction, when the near end two near = 卜 m knife start position, thereby the device is ready 2 need to move the plunger rod outside the hand to facilitate the operation of the device In addition to this, according to the device of the present invention, the tension switch can be used as a tension spring for the drive spring: ί u the device does not need to be pre-tensioned and other advantages before use. 'From the following detailed description and 201116312 [Embodiment] In the current application, the end is the end of the component when the injection is #田ι = & 思思乐物物装置 or side, which means the end of 荜 2 = 3. Similarly, the nearest end device or iliac member is used at the time of injection from the housing 10® ^ ί = the delivery device includes a proximal external 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 蚪 卩 卩 卩 卩 卩 卩. Quite rationally, the outer casing can be styled. The proximal outer casing portion is used as a drug container" portion: moving relative to the end outer casing portion; two are attached thereto. Further, U-needle, mouthpiece, nozzle, etc.) The function is as follows and Hi has two The operating member 18, the device of which further comprises a set of mt" matte threads 2". Single direction; — ΐ-shaped member, which has been referred to as the guide barrel 24 since then, the pattern 2 〇 and the corresponding thread 22 people = the inner surface of the screw of the known peripheral part. The guiding barrel 94 4 / (Fig. b) is located in the sleeve member passage 28 (Fig. 2, the H end = the end wall 26 has a central radial inward protrusion. The column has a flow guiding member 30 as it is provided with the corresponding material The flow structure is Γ and 3 〇 is joined, so that the 裎徂am I longitudinal groove 33 can be used between the protrusions. The plunger rod St 4 IS, ^ five a). The end stopper 34 in a proximal stalk is in contact with the bottle (Fig.). The near stopper 35 is located in the drug container, and the snails are leaked to 36, 38 in the container 14, thereby forming two dry forms of the drug. ), another room 38 heart-substance (such as: dilution) (Figure 5a). The external mass (for example, the liquid causes the end stopper to move against the at least two substances in the relative mover of the Guiyi rod 12 to the near-known movement to mix the capacity 201116312. The guide bucket 24 is provided with a longitudinally extending ratchet 4 On the outer side of the end circumference (Fig. 2) 'here the ratchet 4 合作 cooperates with the ledge 44 of the elastic tongue β 42 on the end outer casing portion 12, and here the ratchet and ledge 4 = makes the guide bucket only relative to The end outer casing portion is twisted in the same direction (Fig. 5a). Further, a lock member 46 (Fig. 3) is designed such that a ring member 48 is provided with two button members 50 at both ends of the diameter of the annular member 48. The two button-like members 5 are protruded through the upper passage portion 52 of the end outer casing portion 12 (Fig. 2). Further, the annular member 48 lock member 54 (e.g., the groove at both ends of the diameter) and the corresponding outer portion of the lock member 5 The upper two ribs are engaged (figure 3). After mixing, when the external position reaches the relative position of the factory, and when the drug container is activated by the proximal outer casing lock, the lock member 54 is released, and the outer casing portions 10 and 12 are moved against each other. When the guide barrel is turned twice, the plunger rod is moved out to the end. The initial sigma position, and the proximal outer casing portion is rotatably biased from the end outer casing portion into the inner end portion of the crucible, and the (four) ground is defined by the circumference of the final casing portion as follows/releasably connected to the driving force The assembly, the driving force assembly includes a driving nut rod 32 interlaced, and the _m58 'nut and the plunger are described as follows; a manual pole is connected to the starting member, and the object 72 can be used. The 1Θ shirring device comprises a resilient tongue shackle that is slidably connected to the ratchet 7〇 of the nut so that the shirring device can only be placed in a single h with respect to the nut and the second end is connected to the end= When the retracting and contracting device is operated, the driving bobbin dm is locked in the contracted state, 201116312 and: when the side starting member is operated, the driving nut is loosened and thus the driving spring The tensioned state is released, whereby the plunger rod moves in the proximal direction to deliver the drug. ° The stem 32 is located within the drive nut 58 and the drive nut 58 is provided with a thread 60 (Fig. 2) for engagement with the thread 62 on the outside of the plunger rod 32. The drive nut 58 is further provided with an annular proximal wall mount 64. A plurality of teeth 66 surround the ledge, the function of which will be described below. The end of the movable nut 58 is provided with an annular portion 68, and the circumferential surface of the ring is provided with a longitudinal stop ledge 70. The manually operated spring-splitting device includes a common tubular drive mechanism 4 and a dose setting button 76. The driving nut is stopped, and the elastic arms 72 cooperate to be located in the ordinary tubular driving member 74^. The end of the driving member 74 protrudes through the end of the end outer casing portion to attach the second rim to the button 76 to rotate the driving member. The cooperation of the truss ledge 70 and the resilient arms 72 causes the 7 〇 / # 72 / month to pass the jT stop wall 70. In the other direction, the elastic arms 2 邻接 point adjacent to the stop ledge 7〇, thus locking the rotation. (For the torsion drive spring) coaxially located at the end of the drive n end of the drive member 74" attached to the device (such as the end housing portion 12). 97 u two doses by using a magazine to pull the device Set, the amount is achieved by the same incremental scale. - A preset scale, the preset scale is quite iff: 疋 疋 76 76 each increment - need to be additional clockwise rotation

的預設劑量,需順時針旋轉刻J 劑量設定叙被旋轉時,驅動構= f ° s 且因此驅動彈菩之一 # + 會相應地旋轉, 纫坪只之知也附於驅動構件74。驅動彈 201116312 簧因此而捲緊並累積與彈筈 的能量。並且彈性臂72滑過停縮止 程度相同 啟動構件包括一環狀構件、 ==動螺帽58的齒狀物66;=:有: 回位弹簧86位於啟動構件8〇的環 ) 和一中心環狀牆88的一 冓件82近鳊面 外殼部12内面上,以进#播 a (圖五b)、末端 互相嚙合。 I使構件猎由齒狀物66、84 裝置運作如下。一荦物空 10内。近端部被手動隹道,於近端外殼部 端=邮^^喃合防止導流桶^走轉^近 ?外设部1G被旋人末端外殼部i 了 2 近端與末端瓶塞34接雜,Mf柱塞才干32的 移動進人藥& 3 1:1末端瓶塞34向近端 也造2近=:7移動近端/ 一、S、苦.、,V*上 移動藉此兩室36、38間產生 端外“Κί背造t藥物混合和稀釋。當近 端外”被=而=入動鎖件46的溝槽54時’近 藉此設定紐76被旋轉, ΐ 78 被紋轉。此碇轉造成扭轉驅動彈 58 ? ^,f±t 72 驅動構件74向二# 72與停止壁架7〇接觸以防 物84^驅動螺帽的齒狀物66與啟動構件的齒狀 =斤接Λ以曰防驅動螺帽58旋轉。劑量設定知76旋 得至所兩劑量設定好為止。 動啟2 在將藥物輸送裝置置於注射處並以手 =411送裝,著回位彈菁⑽之力來滑動 ) 廷4成啟動構件80的齒狀物84從 201116312 帽Γ動Ilf ΐ66移出:由於驅動彈簧累積 夕六也 牛4現在可藉著扭轉驅動彈簧78 接,驅動螺帽58也4轉停止壁架7〇間的連 交蜱的旋轉,與柱塞桿32的螺紋62 二塞桿32與導流桶24旋轉鎖在-起,柱塞柃32可滑動地前進,造 且推出-劑藥物。 &柱塞杯移動瓿塞 輸送構件現在可從注射處移開。 二接=的輸送構件並旋轉劑量設定紐$來 空了且被替換之後,可“以= ^動㈣近端外殼部。為了能夠如此做,鎖件4 48將以放射妝届曲按钮來元成。1^此環狀構件 Μ將^放射狀屈曲,以使溝槽54 10的背脊56離開。近端外殼部u)現在可 ,而由於與導流桶24連結,導流桶24也自| 由彈性舌狀物42以順時針方向 因旋轉鎖位於導流桶和柱塞桿之=:==)。 啟動構件的餘物n使m5 8的齒狀物與 壁架90與導流桶24端二動J =桿32上的圓周 端外殼部ίο相對於導/桶24的=面接觸為止。近 叫a '等机桶24繼續旋棘,蕤μ 外殼部10從導流桶24旌中n ^轉藉此近^ 並替換成-新的藥物容器14樂物容器可被移出 ㈣丨述之ί施方式和附圖只被視為本發明I 例,且本發明在本專利權範圍内可以許;、 201116312 【圖式簡單說明】 本發明在以下詳細說明中,各參照圖如下: 圖一〜二係根據本發明之實體爆炸圖。 圖三係根據本發明之實體近端部詳圖,末端外殼部 被移開。 圖四係根據本發明之元件詳圖。 圖五〜六係根據本發明不同的功能說明之截面圖。 【主要元件符號說明】 ίο 近端外殼部 12 末端外殼部 14 藥物容器 16 頸部 18 操作構件 20 近端外殼部螺紋 22 導流桶螺紋 24 導流桶 30 導引構件 32 柱塞桿 33 導引構件 34 末端瓶塞 40 縱向延伸棘輪 42 彈性舌狀物 44 壁架 46 鎖件 58 驅動螺帽 64 環狀向近端壁架 70 棘輪 72 彈性鎖舌狀物 12 201116312 74 驅動構件 76 劑量設定鈕 78 扭轉驅動彈簧 80 啟動構件 82 環狀構件 86 回位彈簧 七、申請專利範圍: 1.藥物輸送裝置,包括: 一末端外殼部(12); 一近端外殼部(10),一多室藥物容器(14)位於其内, 在此該近端外殼部可相對於該末端外殼部移動,以 混合該容器内的至少兩物質; 二柱塞桿(32)作用於末端瓶塞(34)於該藥物容器内 藉此該外殼部(10、12)向彼此的相對移動迫使該末 端瓶塞倚著柱塞桿向近端移動,以混合該容器 至少兩物質; 一驅動力組件(58、74、76、78)能夠迫使該柱塞桿 向近端移動,以隨之從該藥物容器輸送藥物; 二啟動構件(80)可滑動地穿過該末端外殼部,且可 鬆開地連接於該驅動力組件; 其特徵為該裝置又包括: 二ϊΐ,(24),可單向旋轉於該末端外殼部内,在 有螺紋(22),與該近端外殼上相應之 導槿件ΠίΓ彳且在此該導流桶和該柱塞桿備有引 導構件(30、33)以便旋轉地鎖住,但可相對滑動。 在艮ί申請專利範圍帛1項之藥物輸送裝置, ^ it;備有縱向延伸棘輪(40)於其末端外圓周 在此该棘輪與末端外殼部上彈性舌狀物(42)的 13The preset dose needs to be rotated clockwise. When the dose setting is rotated, the driving mechanism = f ° s and thus one of the driving cymbals # + will rotate accordingly, and the ping is only known to the driving member 74. Drive Bullet 201116312 The spring thus winds up and accumulates energy with the magazine. And the elastic arm 72 slides through the same degree of stopping and the same as the starting member includes an annular member, == the nut 66 of the dynamic nut 58; =: there is: the return spring 86 is located at the ring of the starting member 8) and a center A member 82 of the annular wall 88 is adjacent to the inner surface of the outer casing portion 12 so as to be engaged with each other (Fig. 5b). I causes the component to be hunted by the teeth 66, 84 as follows. A slap in the air 10 inside. The proximal end is manually ramped, at the proximal end of the housing end = mail ^ ^ 合 防止 防止 导 导 ^ 近 近 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设 外设Miscellaneous, Mf plunger only 32 moves into the human medicine & 3 1:1 end stopper 34 to the proximal end also made 2 near =: 7 moving near the end / one, S, bitter.,, V* on the mobile The two chambers 36 and 38 create an end-to-end "mixing and diluting the drug. When the proximal end" is = and = the groove 54 of the locking member 46 is inserted, "nearly the setting button 76 is rotated," 78 is turned. The twisting causes the torsion drive bomb 58?, the f±t 72 drive member 74 contacts the stop ledge 7 to the second #72 to prevent the teeth 84 from driving the nut and the teeth of the actuating member. The joint is rotated to prevent the drive nut 58 from rotating. The dose setting is known to be 76 until the two doses are set. Move 2 to place the drug delivery device at the injection site and send it with hand = 411, and slide back with the force of the elastic (10). The tooth 84 of the activation member 80 is removed from the 201116312 cap tilting Ilf ΐ66. : Due to the accumulation of the drive spring, the yoke 6 can now be connected by the torsion drive spring 78, the drive nut 58 also rotates 4 to stop the rotation of the sill between the sills 7 and the thread 62 of the plunger rod 32 The rod 32 is rotatably locked with the guide barrel 24, and the plunger cymble 32 is slidably advanced to create and push out the drug. & plunger cup moving chops The delivery member can now be removed from the injection site. After the second connection = the conveying member and the rotation dose setting New Zealand$ is empty and replaced, the lower outer casing portion can be "moved" (in order to be able to do so). In order to be able to do so, the locking member 4 48 will be replaced by a radiation button. The annular member Μ will be radially flexed to cause the ridge 56 of the groove 54 10 to exit. The proximal end portion u) is now available, and due to the connection with the guiding barrel 24, the guiding barrel 24 is also self-contained. | by the elastic tongue 42 in the clockwise direction due to the rotation lock located in the guide barrel and the plunger rod =: ==). The remainder of the starting member n makes the teeth of the m5 8 and the ledge 90 and the diversion barrel The 24-terminal two-moving J = the circumferential end outer casing portion on the rod 32 is λ with respect to the surface contact of the guide/bucket 24. The near-a 'equal barrel 24 continues the spine, and the outer casing portion 10 is closed from the guide barrel 24 In the middle of the n ^ and then replaced by - the new drug container 14 music container can be removed (four) description of the manner and the drawings are only considered as an example of the present invention, and the invention is within the scope of this patent BRIEF DESCRIPTION OF THE DRAWINGS In the following detailed description, reference is made to the accompanying drawings in which: FIG. Figure 4 is a cross-sectional view of a different functional description in accordance with the present invention. Figure 5 - 6 is a cross-sectional view of a different functional description in accordance with the present invention. Description] ίο proximal end portion 12 end housing portion 14 drug container 16 neck 18 operating member 20 proximal housing portion thread 22 guide barrel thread 24 guide barrel 30 guide member 32 plunger rod 33 guide member 34 end bottle Plug 40 longitudinally extending ratchet 42 resilient tongue 44 ledge 46 lock 58 drive nut 64 annular proximal wall mount 70 ratchet 72 resilient lock tongue 12 201116312 74 drive member 76 dose setting button 78 torsion drive spring 80 Starting member 82 annular member 86 return spring 7. Patent scope: 1. A drug delivery device comprising: an end outer casing portion (12); a proximal outer casing portion (10), a multi-chamber drug container (14) located Wherein the proximal outer casing portion is movable relative to the distal outer casing portion to mix at least two substances in the container; the second plunger rod (32) acts on the terminal stopper (34) on the drug container Thereby the relative movement of the outer casing portions (10, 12) towards each other forces the end stopper to move proximally against the plunger rod to mix at least two substances of the container; a driving force component (58, 74, 76, 78) The plunger rod can be forced to move proximally to subsequently deliver the drug from the drug container; the second activation member (80) slidably passes through the end housing portion and is releasably coupled to the driving force assembly; The device further comprises: two turns, (24), unidirectionally rotatable in the end outer casing portion, having a thread (22), and a corresponding guide member on the proximal outer casing and guiding the guide member The flow barrel and the plunger rod are provided with guiding members (30, 33) for rotationally locking, but are relatively slidable. The drug delivery device of the 帛ί patent application ,1, is provided with a longitudinally extending ratchet (40) on the outer circumference of the end of the ratchet and the end outer casing portion of the elastic tongue (42) 13

Claims (1)

201116312 74 驅動構件 76 劑量設定鈕 78 扭轉驅動彈簧 80 啟動構件 82 環狀構件 86 回位彈簧 七、申請專利範圍: 1.藥物輸送裝置,包括: 一末端外殼部(12); 一近端外殼部(10),一多室藥物容器(14)位於其内, 在此該近端外殼部可相對於該末端外殼部移動,以 混合該容器内的至少兩物質; 二柱塞桿(32)作用於末端瓶塞(34)於該藥物容器内 藉此該外殼部(10、12)向彼此的相對移動迫使該末 端瓶塞倚著柱塞桿向近端移動,以混合該容器 至少兩物質; 一驅動力組件(58、74、76、78)能夠迫使該柱塞桿 向近端移動,以隨之從該藥物容器輸送藥物; 二啟動構件(80)可滑動地穿過該末端外殼部,且可 鬆開地連接於該驅動力組件; 其特徵為該裝置又包括: 二ϊΐ,(24),可單向旋轉於該末端外殼部内,在 有螺紋(22),與該近端外殼上相應之 導槿件ΠίΓ彳且在此該導流桶和該柱塞桿備有引 導構件(30、33)以便旋轉地鎖住,但可相對滑動。 在艮ί申請專利範圍帛1項之藥物輸送裝置, ^ it;備有縱向延伸棘輪(40)於其末端外圓周 在此该棘輪與末端外殼部上彈性舌狀物(42)的 13 201116312 壁架(44)合作,且在此棘輪 導流管只可相對於末端外殼部m)相接’以致 3.根據申請專利範圍第2項之 Ϊ ί裝J包括一近端外殼部鎖件(46)連接於末、端外 f部’在此當外殼部在混合後到達一特;相= 】裝;=裝= ^_件被啟二= ,合,以致當該外殼部(10、12)互相倚 i,ί也使該導流桶旋轉,藉此該柱塞桿向末端方 =動至初始位置,且近端外殼部從末== 署,申請專利範圍第1至3項之藥物輸送襄 在此該驅動力組件(58、74、76、78)包括. 二,,螺帽(58)與該柱塞桿(32)旋緊唾 可 開地與該啟動構件連接; 勘。且了鬆 :(手= ί縮裝置(74、76)包括彈性鎖舌狀 物(72)了氣、開地與該驅動螺帽的棘輪(7〇) ,,彈簧拉縮裝置只能相對於該驅動螺帽單向 /二^動彈簧(78)有一端連接於該彈簧拉縮裝置, 接於末端外殼部’以致當該彈簧拉縮 J置被刼作時,該驅動彈箐被鎖於拉縮狀態,且每 動構件被操作時,該驅動螺帽被 二 驅動彈簧從拉縮狀態被鬆開,藉此該柱塞桿= 移動以輸送藥物。 細 5.根據申請專利範圍第4項之藥物輸送裝置, 在此該驅動彈簧為扭轉驅動彈簧(78)。201116312 74 Drive member 76 Dose setting button 78 Torsion drive spring 80 Actuating member 82 Ring member 86 Return spring 7. Patent scope: 1. Drug delivery device, comprising: an end housing portion (12); a proximal housing portion (10) a multi-chamber drug container (14) is located therein, wherein the proximal outer casing portion is movable relative to the distal outer casing portion to mix at least two substances in the container; and the two plunger rods (32) function The distal stopper (34) is in the drug container whereby the relative movement of the outer casing portions (10, 12) toward each other forces the end stopper to move proximally against the plunger rod to mix the container with at least two substances; A driving force assembly (58, 74, 76, 78) is capable of forcing the plunger rod to move proximally to subsequently deliver medicament from the drug container; the second activation member (80) slidably passes through the end housing portion, And releasably coupled to the driving force assembly; characterized in that the device further comprises: two turns, (24), unidirectionally rotatable within the end housing portion, on the threaded (22), and the proximal housing Corresponding guidesΠ Here, the guide barrel and the plunger rod are provided with guiding members (30, 33) for rotationally locking, but are slidable relative to each other. The drug delivery device of the 帛ί application patent scope ,1, is provided with a longitudinally extending ratchet (40) on the outer circumference of the end of the ratchet and the end outer casing portion of the elastic tongue (42) 13 201116312 wall The frame (44) cooperates, and the ratchet draft tube can only be connected with respect to the end outer casing portion m) so that 3. According to the second aspect of the patent application, the J includes a proximal outer casing lock (46). ) connected to the end, the outer part f 'here when the outer shell part reaches a special after mixing; phase = 】 loading; = loading = ^ _ pieces are opened two =, so that when the outer casing part (10, 12) Relying on each other, ί also rotates the diversion barrel, whereby the plunger rod is moved to the end position to the initial position, and the proximal end portion is from the end ==, the drug delivery of the patent scopes 1 to 3 is applied. Here, the driving force assembly (58, 74, 76, 78) includes. Second, the nut (58) and the plunger rod (32) are screwed open to the activation member; And loose: (hand = LY shrink device (74, 76) includes elastic locking tongue (72) gas, open the ground and the ratchet of the drive nut (7 〇), the spring pull device can only be relative to The driving nut one-way/two-moving spring (78) has one end connected to the spring tensioning device and connected to the end outer casing portion so that when the spring is contracted, the driving magazine is locked When the moving member is operated, the driving nut is released from the contracted state by the two driving springs, whereby the plunger rod = moving to deliver the medicine. Fine 5. According to the fourth application patent scope The drug delivery device, where the drive spring is a torsion drive spring (78).
TW98138011A 2009-11-10 2009-11-10 Medicament delivery device TWI415643B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW98138011A TWI415643B (en) 2009-11-10 2009-11-10 Medicament delivery device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW98138011A TWI415643B (en) 2009-11-10 2009-11-10 Medicament delivery device

Publications (2)

Publication Number Publication Date
TW201116312A true TW201116312A (en) 2011-05-16
TWI415643B TWI415643B (en) 2013-11-21

Family

ID=44934766

Family Applications (1)

Application Number Title Priority Date Filing Date
TW98138011A TWI415643B (en) 2009-11-10 2009-11-10 Medicament delivery device

Country Status (1)

Country Link
TW (1) TWI415643B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10300209B2 (en) * 2016-12-02 2019-05-28 Shl Medical Ag Feedback element for a medicament delivery device

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8092420B2 (en) * 2004-11-24 2012-01-10 Becton, Dickinson And Company Automatic reconstitution injector device
DE102007016811A1 (en) * 2007-04-05 2008-10-09 Tecpharma Licensing Ag Device for administering a fluid substance from a multi-chamber ampoule

Also Published As

Publication number Publication date
TWI415643B (en) 2013-11-21

Similar Documents

Publication Publication Date Title
US9005160B2 (en) Medicament delivery device
US11865314B2 (en) Medicament delivery device
US9446201B2 (en) Medicament delivery device
AU2010337136B2 (en) Medicament delivery device
US9095657B2 (en) Self-administration medicament delivery device
AU2010254627B2 (en) Medicament delivery device
JP5613225B2 (en) Drug delivery device
TWI464003B (en) Medicament delivery device
EP3474930A1 (en) Actuation mechanism for a medicament delivery device
US9795744B2 (en) Medicament delivery device
CN106255521B (en) Medicament delivery device
TW201116312A (en) Medicament delivery device
CN115003355A (en) Administration control device with immediate feedback when using a dose dial
AU2013206532B2 (en) Medicament Delivery Device
TW201036660A (en) Medicament delivery device

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees