TW201103429A - Triazole compounds carrying a sulfur substituent XI - Google Patents

Abstract

The present invention relates to novel triazole compounds of the formulae I and II as defined below which carry a sulfur substituent, to agricultural compositions containing them, to their use as fungicides and to intermediate compounds used in the method of producing them.

Description

201103429 VI. OBJECTS OF THE INVENTION: TECHNICAL FIELD The present invention relates to a novel triazole compound of the formula I and II having a sulfur substituent as defined below, comprising an agricultural composition thereof as a fungicide Use and intermediate compounds used in the method of its manufacture. [Prior Art Control of plant diseases caused by phytopathogenic fungi is extremely important for achieving high productivity. Plant diseases in ornamental crops, vegetable crops, field crops, alfalfa crops, and fruit crops can significantly reduce productivity, thereby increasing the cost to consumers. The triazole-based derivatives are described in WO 96/41804, WO 96/16048, WO 97/41107, WO 97/43269 and WO 97/44331. These compounds are used against harmful fungi. There is a constant need for a novel compound that is more efficient, less costly, less toxic, safer to the environment, and/or has a different mode of action. SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide compounds having preferred fungicidal activity and/or better crop compatibility. Surprisingly, these objectives are achieved by triazole compounds of the formulae I and II as defined below and the agriculturally acceptable salts of the compounds I and II. Accordingly, the present invention relates to triazole compounds of the formulae I and II and their agriculturally acceptable salts, 149026.doc 201103429

s(〇)mR6 R6a

among them

Het is a saturated, partially unsaturated or cyclic ring containing 1, 2 or 3 hetero atoms selected from the group as a ring member _, 4_, 5-, 6- or 7-member, wherein the heterocyclic ring may have a b, 2, 3 or 4 a substituent r5;, a hetero A is a linear Cl_c5 extension bridge which can be substituted by 1, 2, 3 or 4 substituents R7; Y R1 is 〇, S or NR8; R2, R3 and R4 are independently selected from each other From hydrogen, dentate, OH, SH, n〇2 'cn, Cl_c4 alkyl, Ci_C4 dentate, C2_C4, c2-c4 from dilute, cvC4 fast radical, c2_C4 -block, c3_c8 cycloalkyl, G-C8 dentate alkyl, Cl_C4 alkoxy, Ci_C4 alkoxy, c]-c4_oxy, Cl_C4i alkenyloxy, Cl_c4 alkynyloxy, Ci_C4 haloalkoxy, C3_CS ring oxy, C3_CS Halocycloalkyloxy, c丨_c4 alkylthio, C丨-C4 haloalkylthio, c丨-C4 alkenethio, c丨_c4 haloalienyl, phenyl, phenyl-CVC4 alkyl, The phenyl moiety of the phenyl-Ci_c4 alkoxy group, the phenoxy group, the phenylthio group wherein the last five of the groups mentioned may have 1, 2, 3, 4 or 5 substituents R9; Three 3-, 4-, 5-, 6- or 7*-membered heteroatoms selected from N, 0 and S are saturated, partially unsaturated or a highly unsaturated heterocyclic ring wherein the heterocyclic ring 149026.doc • 4· 201103429 may have 1, 2 or 3 substituents R9; C〇R»〇, C〇〇Ri〇CONR15Ri6, NNi VI S(0)pRi〇 The aliphatic moiety of the above-mentioned group of the towel may have 1, 2 or 3 substituents R18 and wherein the cycloaliphatic moiety of the above-mentioned melon may have 1, 2 or 3 substituents ri9; or R1 and R2 or R3 and R4 together with the carbon atom to which they are attached form a partially unsaturated or maximally unsaturated 5-, 6- or 7-membered carbocyclic ring or a hetero atom containing ruthenium, 2, 3 selected from ruthenium, S and N. a partially unsaturated or maximally unsaturated 5-, 6- or 7-membered heterocyclic ring of a ring member; wherein the carbocyclic or heterocyclic ring may have 1, 2 or 3 substituents R9; each R5 is independently selected from halo, OH , SH, N〇2, CN, Ci_C4 alkylene, K haloalkyl, C2_C4 alkenyl, c2_C4 from alkenyl, C2_Cd, c2-c4 alkynyl, C3_C8 cycloalkyl, c3_C8 functional cycloalkyl, c! -c4 alkoxy, Cl_C4 haloalkoxy, Ci_C4 alkenyloxy, dentenyloxy, Cl-c4 alkynyloxy, Cl-c4 alkynyloxy, C3_C8 cycloalkyloxy, CVC8 halocycloalkoxy , CVC4 alkylthio, Ci_C4 haloalkylthio, c^-c*»嫦thio, c !-C4 haloalkynylthio, phenyl, phenyl-Ci C4 alkyl, phenyl-Cl_(:4 alkoxy, phenoxy, phenylthio wherein the phenyl moiety of the last five mentioned groups May have i, 2, 3, 4 or 5 substituents R9; 3, 4, 5, 6 or 7 members containing ruthenium, 2 or 3 heteroatoms selected from N, oxime and 8 as ring members a saturated, partially unsaturated or maximum unsaturated heterocyclic ring wherein the heterocyclic ring may have fluorene, 2 or 3 substituents R9; COR1. ' c〇〇Rl. And c〇Nr15r16, nr15r16 and S(〇)PR, wherein the aliphatic moiety of the above group may have [, 2 or 3 substituents R, wherein the above-mentioned group is such that the cycloaliphatic moiety may have 149026.doc 201103429 1, 2 or 3 substituents rB; or two groups R5 attached to adjacent ring atoms (of Het) together with the ring atoms to which they are attached form a partially unsaturated or maximum unsaturated 5_, 6_ or 7- a carbon ring or a partially unsaturated or maximal unsaturated 5-, 6- or 7-membered hetero atom containing hydrazine, 2 or 3 heteroatoms selected from hydrazine, S&N, wherein the carbocyclic or heterocyclic ring may be Having 1, 2 or 3 substituent bases 9; R6 is selected from the group consisting of hydrogen, CVCM alkyl, Cl_ClG dentate, c2_CiG dilute, Ca-Ci 稀 dilute, c2_CiG alkynyl, c2_Ci-alkynyl, C3_CM naphthenic a group, a C3-C10_cycloalkyl group, a phenyl group, a phenyl-Ci_c4 alkyl group, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R1" And a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring containing hydrazine, 2 or 3 heteroatoms selected from N, fluorene and 8 as ring members, wherein the heterocyclic ring may have! , 2 or 3 substituents Rii; or in the case where m is 0, may also be selected from _c(= 〇)R, 2, c(= s)r丨2, _s(o)2r, 2, _CN , _p(=q)r13r14, M and the group of the formula

, R3 and R4 are as defined in Formula I Ashes

Het, a, γ, ri, meaning; and # is the point of attachment to the rest of the molecule 149026.doc -6 · 201103429 R is selected from hydrogen 'Ci-C10 alkyl, cvcj alkyl, c2-c10 alkenyl, C2-c1()iS dilute base, c2_Ci. Alkynyl, c2_Ci()^ alkynyl, c3_Ci fluorenyl, C3-C10_cycloalkyl, phenyl, phenyl-Ci_C4 alkyl, wherein the stupid moiety in the last two mentioned groups may have 1 , 2, 3, 4 or 5 substituted base gauges 11 'containing 1, 2 or 3 heteroatoms selected from N, 〇 and s as ring members, 5- or 6-membered saturated, partially unsaturated or aromatic Ring 'wherein the heterocyclic ring may have 1, 2 or 3 substituents R11,

-C(-〇)R丨2, _c(=S)R丨2, -S(〇)2R12, _CN, -P(=Q)R丨3rU and Μ; each R7 is independently selected from halogen, OH, SH, NR, 5R, 6, Ci_C4 alkyl, c, -c4 _ alkyl, C2_C4 alkenyl, C2_C4 _ alkenyl, alkyl, c2-c4 haloalkynyl, c丨·(:4 alkoxy, Ci a -c4 haloalkoxy group, a CrC4 alkylthio group, and a fluorenyl-fluorenyl 4-haloalkylthio group, wherein the aliphatic moiety of the above group may have 1, 2 or 3 substituents R18; or attached to two adjacent carbons The two radicals 7 on the atom together with the carbon atoms to which they are attached form a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated carbon ring or contain 1, 2 or 3 a 3_, 4_ and a partially unsaturated or a maximum unsaturated heterocyclic ring selected from the group consisting of 〇, = 5-, 6- or 7-membered as a ring member of the carbocyclic or heterocyclic and N, the ring may have 1 , 2 or 3 substituents r9;

K 1 4 明恭, 12 < 4 women's base, c2-c4 alkenyl 'c2_c4 block, c2_C4 tooth base, CM methoxy, CVCj methoxy, phenyl, stupid base, t last 2 The phenyl moiety in the reference group may have, 2, 3 1 149026.doc 201103429 or 5 substituents R9; COR1. , COOR10, CONR15R16 and S(0)pR10; each R9 is independently selected from the group consisting of halogen, hydrazine H, SH, NR15R16, CN, N 〇 2, 炫 "基, CVC4 - 炫, c2_c4, c2-C4 halene a group, a c2-c4 alkynyl group, a c2_c4_alkynyl group, a Ci_c4 alkoxy group, a Ci_c4 alkoxy group, a CrC4 alkylthio group, and a cardio-halohalothio group, wherein the aliphatic moiety in the above group may have 1, 2 Or 3 substituents Ris; each Ri? is independently selected from the group consisting of hydrogen, Ci_C4 alkyl, Cl_c4 haloalkyl, C2-C4 alkenyl, C2-C4 alkenyl, C丨_c4 aminoalkyl, phenyl, Phenyl-c "C4 alkyl" wherein the phenyl moiety of the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R9, and contain 1, 2 or 3 selected from hydrazine, a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring having a hetero atom of Ο and S as a ring member, wherein the heterocyclic ring may have 1, 2 or 3 substituents R9; each Ru is independently selected from halogen, 〇H, SH, NR15R16, CN, N02, CVC4 alkyl, CVC4 ixanyl, c2-c4 alkenyl, c2-c4 haloalkenyl, C2-C4 alkynyl, c2-C4 haloalkynyl, alkoxy , CVC4 haloalkoxy, CrC4 alkylthio and (^-(: 4-haloalkylthio), wherein the above group The aliphatic moiety may have 1, 2 or 3 substituents R18; R12 is selected from the group consisting of hydrogen, CVC decyl, c-c10 haloalkyl, CVCM alkoxy, CVCm haloalkoxy, Ci-Cw amine Alkyl, c3-C10 cycloalkyl, C3_C10 halocycloalkyl, phenyl, phenyl-Cl_c4 alkyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R", containing 1, 2 or 3 heteroatoms selected from ruthenium, osmium and S 149026.doc 201103429 5- or 6-membered saturated, partially unsaturated or aromatic heterocycles as ring members, The heterocyclic ring may have an anthracene, 2 or 3 substituents R11, and NR, 5R16; R13 and R14 are independently selected from the group consisting of Cl_Cl〇 alkyl, Ci_c 〇 haloalkyl, c2_c10 dilute, c2-c1() Decenyl, c2-C1()alkynyl, C2-C1()halynyl, C3-C1G cycloalkyl, c3_ClG functional cycloalkyl, Ci_CiG alkoxy, CVCw alkoxy, Ci_c4_alkoxy _c〗 _ci 〇 alkyl, Ci_c4_alkoxy-CrCw alkoxy, d-Cw alkylthio, Ci-Cw haloalkylthio, C2-C1Q alkenyloxy, c2_c.1 ()-alkenylthio , c2_CiG alkynyloxy, C2-C1 (r alkynylthio, (: 3_CiG cycloalkoxy, c3_CiQ•cycloalkylthio, stupyl, phenyl-C i-C4 alkyl, phenylthio, phenyl-Cl_c4 alkoxy and NR15R16; each R15 is independently selected from hydrogen & Cl-c8 alkyl; each Ri6 is independently selected from hydrogen, Cl-C8 alkyl, benzene And phenyl-Cl_c4 alkyl; or R15 and R16 together form a straight chain (:^ or "alkylene bridge or group -CH2CH2OCH2CH2- or -CH2CH2NR丨7CH2CH2-; each R17 is independently selected from hydrogen and (^ -(:4 alkyl; * Each R18 is independently selected from the group consisting of nitro, CN, OH, SH, COR, COOR10, .conr15r16, nr15r16, c3-c6 cycloalkyl, c3-c6 i cycloalkyl, G -C4 alkoxy, c]-C4 haloalkoxy, c3-c6 cycloaloxy, phenyl and phenoxy; each R19 is independently selected from; 6 Schottky, CN, OH, SH, COR10, COOR10, CONR15R16, NR15R16, Ci_c4 alkyl, Ci_c4 dentate, c3_ H9026.doc -9- 201103429 c6 cycloalkyl, C3_C6 halocycloalkyl, c "c4 alkoxy, Cl-c4ii alkoxy, C3-c6 cycloalkoxy, phenyl and phenoxy; Q is hydrazine or S; M is a metal cation equivalent or an ammonium cation of the formula (NRaRbReRd)+, wherein Ra, Rb'RC and Rd are independently selected from each other Hydrogen, Ci_c丨〇 alkyl, phenyl and benzyl, of which the last two And the phenyl moiety in the group may have 1, 2 or 3 substituents independently selected from the group consisting of dentate, CN, nitro, Cl_C4 alkyl, Cl-C4 haloalkyl, Ci_C4 alkoxy, CVC4 Haloalkoxy and NR15R16; m is 0, 1 or 2; and P is 1 or 2. The invention also provides the use of a triazole compound of formula I and guanidine and/or an agriculturally acceptable salt thereof for controlling harmful fungi. The present invention further provides a fungicidal composition comprising the triazole compound of the above formula 1 and/or 11 (also and/or formula W; see below) and/or an agriculturally acceptable salt thereof and a suitable carrier. Suitable agriculturally acceptable carriers are described below. Compounds I and II may exist in one or more stereoisomeric forms. The various stereoisomers include enantiomers, diastereomers, singly isomers and geometric isomers. Those skilled in the art will appreciate that when one stereoisomer is concentrated relative to other stereoisomers or when separated from other stereoisomers, it may be more active and/or may exhibit beneficial effects. Additionally, the skilled artisan knows how to separate, enrich, and/or selectively prepare such stereoisomers. The compounds of the invention may be present as a mixture of stereoisomers [S] I49026.doc m 201103429 (e.g., a racemate), an individual stereoisomer, or an optically active form. It should be understood that the compounds απ are each position/double bond isomer H less in the case where the groups R6/R6a are the same. In the case where r6 (and of course R6a) is hydrogen, the respective compounds I and II are tautomers. δ Suitable agriculturally applicable salts are especially the salts of their cations or the acid addition salts of these acids. The cations and anions respectively have no side effects on the fungicidal action of the compounds. n Suitable cations are especially metal ions. Preferred are sodium and potassium ions; alkaline earth metal ions, preferably ions of calcium, magnesium and barium; and transition metal ions 'preferably manganese, and iron ions; and ammonium ions (if desired, they may have a Ci_c4 a pyridyl substituent and/or a phenyl or a sulfhydryl substituent), preferably isopropanyl, tetramethylammonium, tetrabutylammonium, diammonium benzylammonium, in addition to a scaly ion, a cerium ion, preferably three (Cl 匸 4 alkyl) ruthenium and ruthenium oxide ions, preferably tris(Ci_c4 alkyl) ruthenium oxide. Suitable anions of acid addition salts are mainly gas ions, bromide ions, fluoride ions, hydrogen sulfate, sulfate, dihydrogen phosphate, hydrogen phosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluoride. An anion of citrate, hexafluorophosphate, and an anion of c丨-C:4 succinic acid, preferably formate, acetate, propionate and butyrate. It can be formed by reacting with a corresponding anion of hydrazine, preferably hydrochloric acid, hydrobromic acid, acid, phosphoric acid or nitric acid. In the definition of the variables given in the above formula, generally representative collective terms are used for the substituents in question. The term Cn_Cm denotes the number of possible carbon atoms in the substituent or substituent moiety in each case: halogen: fluorine, chlorine, bromine and iodine; »49026.doc 201103429 alkyl and alkoxy, alkoxy Alkyl, alkoxyalkoxy, alkylcarbonyl, thiomethyl, aminoalkyl, alkylamino, dialkylamino, alkylaminocarbonyl, dialkylaminocarbonyl, alkane An alkyl moiety in a thio group, an alkylsulfonyl group or the like: having 1 to 2 alkyl groups, 2 or 3 (C2-C3 alkyl groups), 1 to 4 (CVCU alkyl groups), 1 A saturated linear or branched hydrocarbon group of up to 6 (CrCe alkyl), 1 to 8 (CrC8 alkyl) or 1 to 10 (CrCw alkyl) carbon atoms. CyC: 3 alkyl is ethyl, n-propyl or isopropyl. The Cl_C2 alkyl group is a mercapto group or an ethyl group. C1-C4 alkyl is decyl, ethyl, propyl, isopropyl, butyl, 1-methylpropyl (second butyl), 2-methylpropyl (isobutyl) or 1,1 - dimethylethyl (t-butyl). The Cl-C6 alkyl group is additionally, for example, pentyl, 1-decylbutyl, 2-mercaptobutyl, 3-nonylbutyl, 2,2-dimercaptopropyl, 1-ethylpropane 1,1 -didecylpropyl, L2-dimercaptopropyl, hexyl, 1-decylpentyl, 2-methylpentyl, 3-mercaptopentyl, 4-methylpentyl, 1,1_-mercaptobutyl,-dimercaptobutyl, 1,3-dimethylbutyl, 2,2-dimercaptobutyl, 2,3-dimethylbutyl, 3,3- Dimercaptobutyl, 1-ethylbutyl, 2-ethylbutyl, ι,ι,2-trimethylpropyl, tridecylpropyl, 1-ethyl-1-mercaptopropyl or 1_ethyl 2 -methylpropyl. The Cl_c8 alkyl group is also additionally, for example, heptyl, octyl, 2-ethylhexyl and its positional isomers. The C?Cio alkyl group is also additionally, for example, an indenyl group, a fluorenyl group, a 2-propyl heptyl group, a 3-propylheptyl group, and a positional isomer thereof. Haloalkyl: having 1 to 2 (CVC2 functional alkyl), 1 to 3 haloalkyl) '1 to 4 (CVC4 alkyl), 1 to 6 (CVC6 halogen), 1 to 8 a linear or branched alkyl group (C, -C8_alkyl), 1 to 1 (Ci_Ci), or 2 to 1 ((2: C10) alkyl) Said), wherein some or all of the hydrogen atoms in the group such as 149026.doc •12·201103429 may be substituted by a (iv) atom as described above. In particular, Ci-C2 haloalkyl, such as chloromethyl, Bromoguanidino-dichloromethyl, trichloromethyl, gas-agriculture, -Wengtian I _ 鼠 丞 T丞- 曱 曱 、, 曱 曱 、, fluorofluoromethyl, di-fluoromethyl, chlor Fluoromethyl, b-ethyl, i-bromomethyl, fluoroethyl, 2-£ethyl, 2,2-dioxaethyl, 2,2,2_tris, ethyl 2-chloro 2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-ylethyl, 2,2,2-dichloroethyl or pentafluoroethyl 'CVC3 halane Further, the group is (for example, "trifluoropropyl-2-yl, 3,3,3-trifluoropropyl or heptafluoropropyl. C^C4 haloalkyl is additionally (for example) 1-chlorobutyl, 2 -Chlorobutyl, 3-oxobutyl or 4-tert-butyl. (VCm Alkyl·· has} to 2 (Ci_C2 hydroxyalkyl), one (Ci_C4 radix), 2 to 4 (C2-C4 burned), 1 to 6 (C "C6 burned") 2 to 6 (C2-C6 calcined), 1 to 8 (Cl_C8 calcined), 2 to 8 (c2-c8 calcined), hydrazine to 10 (Cl_Cl. calcined) or a linear or branched alkyl group of 2 to 1 (C2_Ci through alkyl) carbon atom (as described above) wherein at least one hydrogen atom is replaced by a hydroxyl group, such as 2-hydroxyethyl or 3-hydroxypropyl a dilute moiety in a dilute group and a dilute oxy group, a dilute thio group, a dilute yl group, and the like: having 2 to 4 (C2-C4 alkenyl) groups, 2 to 6 (C2-C6 alkenyl groups) 2 to 8 (C2-C8 alkenyl), 3 to 8 (C3-C8 alkenyl), 2 to 10 (C2-C1G alkenyl) or 3 to 1 (C3-C1() alkenyl a monounsaturated linear or branched hydrocarbon group having a carbon atom and a double bond at an arbitrary position, for example, a C2-C4 alkenyl group such as a vinyl group, a 1-propenyl group, a 2-propenyl group, a 1-methylvinyl group , 1-butenyl, 2-butenyl, 3-butenyl, 1-mercapto-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl or 2 - mercapto-2-propanoid Or, for example, (: 2-(:6 alkenyl) such as vinyl, 1-propenyl, 2-propenyl, 1-decylvinyl, 149026.doc •13·201103429 1-butenyl, 2 -butenyl, 3-butenyl, 1-decyl-fluorenyl-propenyl, 2-methyl-1-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl ,Pentenyl, 2-pentenyl, 3-pentenyl, 4-pentanyl, iota-methyl-1-butanyl, 2-methyl-1-butenyl, 3·τ-丨_butenyl' 丨methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, iota-yl-3-butanyl, 2- Methyl-3-butylenyl, 3-mercapto-3-butenyl, dimethyl-2-propenyl, 1,2-diindenyl-1-propenyl, iota, 2·didecyl _ 2-propenyl, ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexene , 1-mercapto-fluorenyl-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-i-pentenyl, i-fluorenyl -2-pentenyl, 2-methyl-2-pentenyl, 3-nonyl-2-pentenyl, 4-methyl-2-pentenyl, 1-decyl-3-pentenyl , 2-mercapto-3-pentenyl, 3 - 3-pentenyl, 4-mercapto-3-pentenyl, 1-decyl-4-enopentyl, 2-methyl-4-pentenyl, 3-mercapto-4-pentene Base, 4-mercapto-4-pentenyl, 1,1-dimethyl-2-butenyl, iota, ι-diyl-3-butenyl, j,2-didecyl a-butene 1,2-dimercapto-2-butenyl, iota, dimethyl-3-butenyl, iota, 3-didecyl-butenyl, 1,3-dimethyl Butenyl, i,3-dimethyl-3-butenyl, 2.2-dimethyl-3-butenyl, 2,3-diindenyl-ι-butenyl, 2,3-didecyl 2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3.3-dimercapto-2-butenyl, 1-B Base — 丨·butenyl, 丨_ethyl 2 —butenyl, 1-ethyl-3-butenyl, 2-ethyl-1-butenyl, 2-ethyl-2-butenyl , 2-ethyl-3-butenyl, l,l,2-trimethyl-2-propenyl, 1-ethyl-1-indenyl-2-propenyl, 丨_ethyl_2_曱a group of hydrazine-propenyl, acetophen-2-ylindolyl-2-propenyl and the like;

[SI 149026.doc • J4· 201103429 Toothed bases in halogenated and halooxy, halocarbyl and analogues thereof: having 2 to 4 (C2-C4i alkenyl), 2 to 6 (C2-C6 haloalkenyl), 2 to 8 (CyC: 8 haloalkenyl) or 2 to 10 (C2-Ci〇 haloalkenyl) carbon atoms and the double bond of the double bond at the position of Rens a direct bond or a bond radical (as described above), wherein some or all of the hydrogen atoms of the % group can be replaced by dentate atoms (especially dry, gas and desert) as described above, such as vinyl chloride, gas Mercaptopropyl and analogs thereof; fast radical moiety in alkynyl and alkynyloxy, alkynylthio, alkynyl and analogs thereof. 2 to 4 (C2-C4 alkynyl), 2 to 6 (C2-C6 alkynyl) '2 to 8 (C2-C8 alkynyl), 3 to 8 (C3-C8 alkynyl), 2 to 10 (C2-C1Q alkynyl) or 3 to 10 (C3_C a 1 〇 alkynyl) carbon atom and one or two straight or branched chain hydrocarbon groups at any position, for example, a C2-C4 alkynyl group, such as an ethynyl group, a 1-propynyl group, a 2-propanyl group , 1-butyryl, 2-butyryl, 3-butyryl or 1-methyl-2-propynyl, or for example C2-C6 fast radicals, such as ethyl bromide, 1-propanyl, 2-propanyl, 1-butanyl, 2-butynyl, 3-butynyl, 1-methyl-2-propyne , 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-indolyl-2-butynyl, 1-indolyl-3-butynyl, 2- Mercapto-3-butanyl, 3-methyl-1-butenyl, 1,1-dimercapto-2-propynyl, 1-ethyl-2-propynyl, 1-hexynyl , 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-indolyl-2-decynyl, 1-indolyl-3-pentynyl, 1-indole 4-pentynyl, 2-mercapto-3-pentynyl, 2-mercapto-4-pentynyl, 3-methyl-1-pentynyl, 3-mercapto-4-pentyne Base, 4-methyl-1-pentynyl, 4-mercapto-2-pentynyl, 1,1-didecyl-2-butynyl, 1,1-didecyl-3-butyne 1,2-dimercapto-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-didecyl- 149026.doc •15- 201103429 1-butynyl , 1-ethyl-2-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1-ethyl-1-indenyl-2-propanyl and Analogs thereof; alkynyl moiety in a haloalkynyl group and an il-oxyl group, a tooth-based carbon group, and the like: having 2 to 4 (C) 2-C4 haloalkynyl), 2 to 6 (C2-C6||alkynyl), 2 to 8 (C2-C8ii alkynyl) or 2 to 10 (C2-C10-alkynyl) carbon atoms and one Or two inactive, 3⁄4, a positional unsaturated bond or a bond group (as described above), wherein some or all of the hydrogen atoms of such groups may pass through a halogen atom as described above ( In particular, fluorine, gas and bromine) substitution; cycloalkyl groups in the cycloalkyl and cycloalkoxy groups, ring-based carbonyl groups and the like: having 3 to 6 (CVC6 cycloalkyl groups), 3 to 8 a monocyclic saturated hydrocarbon group of (C3-C8 cycloalkyl) or 3 to 10 (C3_C1G cycloalkyl)carbocyclic members, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, ring Octyl, cyclodecyl and cyclodecyl; torsocycloalkyl moiety in halocycloalkyl and cycloalkoxy, cycloalkylcarbonyl and the like: having from 3 to 6 (CVC6 ring cycloalkyl) , 3 to 8 ((: 3_Cs halocycloalkyl) or 3 to 10 (C3_C10 halocycloalkyl) carbocyclic ring members of a monocyclic saturated meridine (as described above), some or all of which may be a halogen atom (especially fluorine) as described above Gas and bromine) substitution; cyclodecyl and cycloalkenyloxy, cycloazinyl thiol and the like thereof to give a ring-like moiety: 3 to 6 (CVC: 6 ring-dense), 3 to 8 ( a monocyclic monounsaturated hydrocarbon group of a C3_c8 cycloaliphatic) or 3 to 10 (C3-C1G cycloalkenyl) carbocyclic ring members, such as a cyclopropenyl group, a cyclobutenyl group, a cyclopentenyl group, a cyclohexenyl group, a ring Heptenyl, cyclooctenyl, cyclodecenyl and cyclodecenyl; halocyclo and ortho-alkenyloxy, functional ring dilute carbonyl and the like 149026.doc •16-201103429 halo ring Alkenyl moiety: a single production order having 3 to 6 (CrC6 halocycloalkenyl), 3 to 8 (<: halocyclo) or 3 to 10 (C3_C10 halocycloalkenyl) carbon ring members a saturated hydrocarbon group (as described above) wherein some or all of the hydrogen atoms may be replaced by a halogen atom as described above (especially fluorine, chlorine and bromine); a cycloalkyl group - Ci-C2 alkyl group: as described above (^_( ^2 A pyridyl group in which one of the hydrogen atoms is replaced by a C3-C6 cycloalkyl group. Examples are cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, cyclopropylphosphonium, cyclobutyl-1-ethyl, cyclopentyl-1-ethyl, cyclohexyl Ethyl, cyclopropyl-2-ethyl, cyclobutyl-2-ethyl, cyclopentyl-2-ethyl, cyclohexyl-2-ethyl and the like. The C3-C1()cycloalkyl-Ci-C4 alkyl group is a Ci-c:4-based residue as described above in which one hydrogen atom is replaced by a C3_Cig cycloalkyl group. In addition to the above-mentioned groups, examples of the CrC6 cycloalkyl-Ci-q alkyl group are also cycloheptylmethyl, cyclooctylfluorenyl, cyclodecylmercapto, cyclodecylmethyl, Cycloheptyl-1-ethyl, cyclooctyl-1-ethyl, cyclodecyl-丨-ethyl, cyclodecyl-1-ethyl, cycloheptyl-2-ethyl, cyclooctyl-2 -ethyl, cyclodecyl 2·ethyl 'cyclodecyl-2-ethyl, cyclopropyl_ι-propyl, cyclopropyl-2-propyl, cyclopropyl-3-propyl, ring Butyl-i-propyl, cyclobutyl-2-propyl, cyclobutyl-3-propyl, cyclopentyl-1-propyl, cyclopentyl-2-propyl, cyclopentyl-3 , cyclohexyl-1-propyl, cyclohexyl-2-propyl, cyclohexyl-3-propyl, cycloheptyl-1-propyl, cycloheptyl-2-propyl, cycloheptyl_3_ Propyl, cyclooctyl-yl-propyl, cyclooctyl-2-propyl, cyclooctyl_3-propyl, cyclodecyl-1-propyl, cyclodecyl-2-propyl, cyclodecyl 3-propyl, cyclodecyl·ι·propyl, cyclodecyl _ 2-propyl, cyclodecyl-3-propyl, cyclopropyl-fluorenyl butyl, cyclopropyl-2-butyl, Cyclopropyl-3-butyl, cyclopropyl-4-butyl, cyclobutyl-1-butyl, ring 149026.doc •17- 201103429 Butyl-2-butyl , cyclobutyl-3-butyl, cyclobutyl-4-butyl, cyclopentylbutyl, cyclopentyl-2-butyl, cyclopentyl-3-butyl, cyclopentyl_4_butyl , cyclohexyl-1-butyl, cyclohexyl-2-butyl, cyclohexyl-3-butyl, cyclohexyl-4-butyl, cycloheptyl-1-butyl, cycloheptyl-2-butyl Cycloheptyl-3-butyl, %heptyl-4-butyl, ε-octyl-1-butyl, cyclooctyl-2-butyl, cyclooctyl-3-butyl, cyclooctyl -4-butyl, cyclodecylbutyl, cyclodecyl-2-butyl, cyclodecyl-3-butyl, cyclodecyl-4-butyl, cyclodecyl-hydrazine-butyl, cyclodecyl 2-Butyl, cyclodecyl-3-butyl, cyclop-butyl 4-butyl and the like. C3, C6 halocycloalkyl-C]-C2, the base: as described above, c! -C2 alkyl residue, wherein one of the hydrogen atoms is replaced by a CrC6 halocycloalkyl group. Examples are gas cyclopropyl fluorenyl ' 1-cyclohexyl fluorenyl, 1-cyclopentylmethyl, oxacyclohexylmethyl, 1-cyclohexyl-1-ethyl, 1- Gas ring butyl 丨 乙基 ethyl, cyclohexane cyclopentyl-1-ethyl, 1-cyclohexyl-1-ethyl, cyclohexane propyl 2-ethyl, κ gas cyclobutyl -2- Ethyl, 1-cyclopentyl-2-ethyl, 1-chlorocyclohexyl-2-ethyl, 2-cyclohexylmethyl, 2-cyclopentyl fluorenyl, chlorocyclopentyl fluorenyl , 2-cyclohexylmethyl, 2-cyclohexyl-hydrazine-ethyl, 2-cyclopentylethyl, 2-cyclopentylethyl, 2-cyclohexylethyl, xenon Cyclopropyl-2-ethyl, 2-chlorocyclobutyl-2-ethyl, 2-cyclopentyl-2-ethyl, 2-chlorocyclohexyl-2-ethyl, 1-fluorocyclopropyl hydrazine Base, 丨-fluorocyclobutylmethyl, fluorocyclopentylmethyl, fluorocyclohexyl fluorenyl, hydrazine fluorocyclopropyl hydrazine 乙基 ethyl, hydrazine butyl-1-ethyl, 1-fluoro Cyclopentyl-indole-ethyl, fluorenylfluorocyclohexyl-indole-ethyl, 1-fluorocyclopropyl-2-ethyl, 1-fluorocyclobutyl-2-ethyl, hydrazine-fluorocyclopentyl -2-ethyl, 丨-fluorocyclohexyl 2•ethyl, 2-fluorocyclopropyl fluorenyl, 2-fluoro ring [S] 149 〇 26.d〇c • 18· 201 103429 butyl fluorenyl, 2-fluorocyclopentylmethyl, 2-fluorocyclohexyl decyl, 2-fluorocyclopropyl-1-ethyl, 2-fluorocyclobutyl-1-ethyl, 2-fluoro Cyclopentyl-1-ethyl, 2-fluorocyclohexyl-1-ethyl, 2-fluorocyclopropyl-2-ethyl, 2-fluorocyclobutyl-2-ethyl, 2-fluorocyclopentyl _2-Ethyl, 2-fluorocyclohexyl-2-ethyl and the like. . 3-(:10 halocycloalkylhydrazine-c4 alkyl is a C丨-C4 alkyl residue as described above, wherein one hydrogen atom is replaced by (:3-(:10 halocycloalkyl). - The alkyl group alkoxy group via an oxygen group is a methoxy group or an ethoxy group. The C-C3 alkoxy group is additionally, for example, n-propoxy or fluorenylmethylethoxy (isopropoxy). Ci-C: 4 alkoxy is additionally (for example) butoxy, 丨-methylpropoxy (second butoxy), 2-methylpropoxy (isobutoxy) or 1}1_ Dimercaptoethoxy (third butoxy Cl_C6 alkoxy group is additionally exemplified by, for example, pentyloxy, 1-methylbutoxy, 2-f-butoxy, 3-methylbutoxy, u · 1-Methylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, puethylpropoxy, hexyloxy, 丨-methylpentyloxy, 2_曱Pentyl pentyloxy, 3-methylpentyloxy, 4·methylpentyloxy, dimethyl butyloxy, hydrazine, 2-dimethylbutoxy, 1,3-dimethylbutoxy , 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, ethylideneoxy, 2-ethylbutoxy, 1,1 2-trimethylpropoxy , 〗 〖, 2,2_trimethylpropoxy, ethethyl-1-methylpropoxy or !-ethyl-whenylmethylpropoxy. The decyloxy group is additionally (for example) heptyloxy, octyloxy , 2-ethylhexyloxy and positional isomers thereof. C,-. Alkoxy is additionally, for example, a decyloxy group, a decyloxy group and a positional isomer thereof. C2-C10 alkoxy is similar In the oxy group, but the methoxy group is eve 0' which is via fluorine, chlorine, bromine and/or halogen alkoxy group: alkoxy group as described above 149026.doc -19- 201103429 for 'perfect fluorine partial or complete Substituted. c--c2 haloalkoxy is, for example, OCH2F, 〇CHF2, 〇CF3, 〇CH2Cn, 0CHC12, 0CC13, fluorofluoromethoxy, difluorofluoromethoxy, fluorodifluoromethoxy, 2_ Fluoroethoxy, 2-methoxyglycol, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2.2.2-trifluoroethoxy, 2_gas·2 Fluoroethoxy, 2_gas_2,2 difluoroethoxy, 2,2-dioxa-2-fluoroethoxy, 2,2,2-trisethoxy or guanidine C2f5. Further, C4 _ alkoxy is, for example, 2-fluoropropoxy, 3-fluoropropoxy, 2.2-difluoropropoxy, 2,3-difluoropropoxy, 2-propoxy, hongqi Propoxy, 2, 3-dipropoxy, 2-bromopropoxy, 3-bromopropoxy, 3,3,3-trifluoropropoxy, 3,3,3-tripropoxy, OCH2_C2F5, 〇CF2_c2F5 , 1-(CH2F)-2-fluoroethoxy, WCH2C1)_2_gas ethoxy, 1(CH2Br)_ 2-bromoethoxy, 4-fluorobutoxy, 4- methoxybutoxy, 4 _Bromobutoxy or nonafluorobutoxy. Ci-C6 haloalkoxy is additionally, for example, 5·fluoropentyloxy, 5-chloropentyloxy, 5-bromopentyloxy, hexyloxy, 6- Gas hexyloxy, hexyloxy. 5-峨-pentyloxy, undecafluoropentyloxy, 6-fluoro 6-bromohexyloxy, 6-iodohexyloxy or dodecafluoroaloxy-. via the oxygen atom as described above Alkenyl, for example,

-Methyl-2-butenyloxy, 1-149026.doc ^Methyl-2-butenoxyoxy, 1-methyl-3-[S1 •20· 201103429 Butanoxy, 2-methyl -3_butenyloxy, 3-methyl-3-indolyl, i-xyl dimethyl-2-propenyloxy, dioxin-based acetophenoxy, dimethyl-2-enyloxy , 1-ethyl propylene oxy, κ ethyl propylene oxy, "hexenyloxy, 2-hexyloxy, 3-hexenyloxy, 4-hexyloxy, 5-hexyloxy , 1-methyl-1-pentenyloxy, 2-methylpentanyloxy, 3-methyl-1-pentyloxy, 4-methylpentyloxy, 丨-methyl _2•pentenyloxy, 2·indol-2-pentenyloxy, 3-methyl-2-pentenyloxy, 4-methyl-2-indoleoxy, 1-methyl-I Alkenyloxy, 2-methyl·3·decyloxy, 3·methyl_3·pentenyloxy, 4-fyl-3-butenyloxy, “methyl-4-penteneoxy” ' 2 —Methyl-p-pentyloxy, phenyl-4-pentyloxy, 4-methyl-4-pentenyloxy, 1,1-di-f-yl-2-butanoxy, i Methylene-3,butoxyl, 1,2-didecyl-1-butenyloxy, benzyl-2-butanoxy, dimethyl-butenoxy Dimethyl]•butylene oxide With dimethyl I butyleneoxy, 1,3-dimethyl 3 - butyloxy, 2,2 dimethyl _ 3 - butyloxy, 2,3-dimethyl butyl Alkenyloxy, 2,3-dimethyl-2-butenyloxy, 2,3-dimethyl-3-butenyloxy, 3,3-diindolyl-4-butenyloxy, 3,3 · dimethyl-2·butoxy, ethyl, butyloxy, ethyl-2-butanoxyhethyl-3-butenyloxy, 2-ethyl-oxime-butenyloxy 2, ethylbutenyloxy 2_ethyl-3-butenyloxy, ι,ι,2-trimethyl-2-propenyloxy, 1-ethylmethyl-2-propenyloxy, 1-ethyl-2-methyl-1-propenyloxy and 1-ethyl-2-indolyl-2-propenyloxy and the like; _thinoxy: a diloxy group as described above, Fluorine, gas, and/or iodine, preferably partially or completely substituted by fluorine. Alkynyl group: an alkynyl group as described above attached via a ruthenium atom, for example, I49026.doc • 21 · 201103429 C2-c1G alkyne Oxyl group, such as 2-propynyloxy, 2-butynyloxy, 3-butynyloxy, 1-methyl-2-propynyloxy, 2-pentynyloxy, 3-pentynyloxy , 4_pentynyloxy, fluorenyl-2-butynyloxy, 丨-methyl·3 butynyloxy, 2· Methyl-3-butynyloxy, 1-ethyl-2-propynyloxy, 2-hexynyloxy, 3hexynyloxy '4-hexynyloxy, 5-hexynyloxy, A Alkynyloxy, benzyl-3-pentynyloxy and the like; _alkynyloxy: alkynyloxy as described above, which is preferably fluorine, chlorine, bromine and/or iodine, preferably fluorine Partially or completely replaced. a cycloalkyloxy group, a cycloalkyl group as described above attached via an oxygen atom, such as 'C3-C1G ring alkoxy or CpC: 8 ring alkoxy, such as cyclopropoxy, cyclopentyloxy, cyclohexyloxy a group, a cycloheptyloxy group, a cyclooctyloxy group, a cyclodecyloxy group, a cyclodecyloxy group and the like; a halocycloalkoxy group: a cycloalkoxy group as described above, which is fluorine, gas, bromine and/or Or iodine, preferably partially or completely substituted by fluorine. Cyclooxyl: a cycloaliphatic group as described above attached via an oxygen atom, such as 'C3-C1G cycloalkenyloxy, C3-C8 cycloalkenyloxy or preferably, c5-C6 cycloalkenyloxy' such as cyclopentane 1-enyloxy, cyclopentenyloxy, cyclohexanyloxy and cyclohex-2-enyloxy; alkoxyalkyl: 1 to 10, 1 to 8, 1 to 6 or 1 to 4 groups of alkyl groups as defined above, especially 1 to 3 carbon atoms, wherein one hydrogen atom has 1 to 8, 1 to 6, 1 to 4 or 1 to 3 carbon atoms The oxy group is substituted, for example, a decyloxy group, a methoxyethyl group, an ethoxymethyl group, a 3-methoxypropyl group, a 3-ethoxypropyl group, and the like. Alkoxyalkoxy: having 1 to 1 、, 1 to 8, 1 to 6, or 1 to 4

[SI 149026.doc • 22-201103429, especially alkoxy groups as defined above for 1 to 3 carbon atoms, wherein one hydrogen atom has from 1 to 8, 1 to 6, or especially to 4 carbon atoms The alkoxy group is substituted, for example, 2-methoxyethoxy, 2-ethoxyethoxy, 3-methoxypropoxy, 3-ethoxypropoxy and the like. Alkylcarbonyl: a group of the formula R-CO- wherein R is an alkyl group as defined above, for example, q-Cw alkyl, Cl-c8 alkyl, c丨_C6, and Ci_c^'q- C2 alkyl or CVC4 alkyl. Examples are ethyl acetyl, propyl thiol and the like. Examples of the CrC4 alkylcarbonyl group are a propylcarbonyl group, an isopropylcarbonyl group, a n-butylcarbonyl group, a second butylcarbonyl group, an isobutylcarbonyl group and a tert-butyl group. Haloalkylcarbonyl: a group of the formula R-CO-, wherein Han is a haloalkyl group as defined above, for example, Cl-Cloi alkyl, Ci_Cs haloalkyl, Ci_C6 dentate alkyl, c--c4-alkyl , Cl_c2_alkyl or c3_c4 from alkyl. Examples are difluoromethylcarbonyl, trifluoromethylcarbonyl, 2,2-difluoroethylcarbonyl, 2,2,3-trifluoroethylthio and the like. Alkoxycarbonyl: a group of the formula R-CO-, wherein R is alkoxy as defined above, for example, Cl_ClQ alkoxy, Ci_Cs alkoxy, c)-c6 alkane 2, CrC4 alkoxy or Ci_C2 alkane Oxygen. Examples of the Ci_C4 alkoxycarbonyl group are a methoxycarbonyloxymethyl group, a propoxymethyl group, an isopropoxymethyl group, a n-butoxymethyl group, a second butoxycarbonyl group, an isobutoxycarbonyl group and a third butoxycarbonyl group. P-Alkyloxycarbonyl: a group of the formula R-CO-, wherein r is a functional alkoxy group as defined above, for example, C1_C10 halo-oxyloxy, C1U- tothoxy' c6-alkoxy, Ci_C4 aldentyloxy Or Ci_C2 tooth alkoxy. Examples of the Ci_c-decaneoxycarbonyl group are difluorofluorenyloxycarbonyl, trifluorosulfonyloxycarbonyl, 2,2-difluoro 149026.doc • 23·201103429 ethoxycarbonyl, 2,2,3-trifluoroethoxycarbonyl and analog. Alkylaminocarbonyl: a group of the formula R-NH-CO-, wherein r is alkyl as defined above, eg, 'VCiq alkyl, C丨-C8 alkyl, C丨-C6 alkyl, C" C4 alkyl, (VC2 alkyl or C3-C4 alkyl. Examples of CVC4 alkylaminocarbonyl are methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl 'isopropylaminocarbonyl, butyl Alkylaminocarbonyl, a second butylaminocarbonyl, an isobutylaminocarbonyl and a tert-butylaminocarbonyl. A dialkylaminocarbonyl: a group of the formula RR'N-CO-, wherein R and R 'Alternately, each other is an alkyl group as defined above, for example, Ci_Ciq alkyl, yl, C-C6 alkyl, c丨-C4 alkyl, c丨-c2 alkyl or c3-c4 alkyl. Examples of C "C4 alkyl"-aminocarbonyl are dinonylaminocarbonyl, diethylamino, dipropylaminocarbonyl, diisopropylaminocarbonyl and dibutylaminocarbonyl. Aminoalkyl group: a group of the formula R-NH2, wherein R is an alkyl group as defined above, for example, 'CVC m alkyl, C丨-C8, CVC6 alkyl, (VC4, thio, Ci-C2 alkyl) Or a C3-C4 alkyl group. Examples are aminomethyl, hydrazine and 2-aminoethyl, 1-, 2- and 3-aminopropyl, i- and 2-amino 1-nonylethyl, 1-, 2-, 3- and 4-aminobutyl and the like. a group of RS(0)2- wherein r is a deutero group as defined above, for example 'C丨·Ch> alkyl, CVC8 alkyl, CVC6 alkyl, C, -C4 or C^-C2 alkane Examples of alkylsulfonyl groups are methanesulfonyl, ethyl, propylsulfonyl, isopropylsulfonyl, n-butylsulfonyl, second sulfhydryl, isobutyl sulfhydryl and The third alkyl group is a thiol group: an alkyl group as defined above which is bonded via a sulfur atom. 149026.doc •24- 201103429 Haloalkylthio: a t-alkyl group as defined above attached via a sulfur atom. Base: a dilute group as defined above attached via a sulfur atom. Halogenthio group: a dilute group as defined above attached via a sulfur atom. Alkynylthio group: an alkynyl group as defined above attached via a sulfur atom. Thio group: a treadyl group as defined above attached via a sulfur atom. A cycloalkyl group: a cycloalkyl group as defined above attached via a sulfur atom. An aryl group is a carbocyclic ring having 6 to 16 carbon atoms as a ring member. Aromatic single Or polycyclic. Examples are phenyl, naphthyl, onion, phenanthryl, yl and base. The aryl is preferably phenyl or naphthyl, and especially phenyl. phenyl_Cl_C4 alkyl ··Cl_C4 a group (as defined above) wherein one hydrogen atom is replaced by a phenyl group, a benzyl group, a phenethyl group and the like. Phenyl-C丨-C4 alkoxy group: @ / r , _ &,...

, 5-, 6- or 7_ member saturated, partially unsaturated or maximal unsaturated

149026.doc ~... The external group reads the hetero atom of the page and the group of C(=〇) and C(=S) as the ring member: 201103429 -3- or 4-member saturated or partially unsaturated a ring (hereinafter also referred to as a heterocyclic group) containing 1, 2 or 3 groups derived from oxygen, nitrogen (in the form of N*NR) and sulfur (in the form of S, SO or S〇2) a hetero atom and, optionally, 1 or 2 groups selected from C(=0) and C(=s) as ring members: for example, a 'monocyclic saturated or partially unsaturated heterocyclic ring, except for a carbon ring member In addition, it also contains 1 to 3 nitrogen atoms and/or 1 oxygen or sulfur atom or i or 2 oxygen and/or sulfur atoms and optionally 1 or 2 selected from c(=〇) and c a group of (=S) such as 2-epoxyethyl, 2-thiopropyl, or aziridine, 1-, 2- or 3-azetidinyl, -5- or a 6-membered saturated or partially unsaturated heterocyclic ring (hereinafter also referred to as a heterocyclic group) containing 1, 2 or 3 derived from oxygen, nitrogen (in the form of N* NR) and sulfur (in S, SO or a hetero atom of the group consisting of S〇2 and optionally 1 or 2 groups selected from C(=0) and C(=S) as ring members: for example Monocyclic saturated or partially unsaturated heterocyclic ring containing, in addition to a carbon ring member, 1 to 3 nitrogen atoms and/or 1 oxygen or sulfur atom or one or two oxygen and/or sulfur atoms and optionally One or two selected from the group consisting of c(=〇) and c(=s), for example, '2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 3-tetrahydrofuran-2-one, 4-tetrahydrofuran-2 -keto,5-tetrahydrofuran-2-yl, 2-tetrahydrofuran-3-one, 4-tetrahydrofuran-3-yl, 5-tetrahydrofuran-3-one, 2-tetrahydrothiophenyl , 3-tetrahydrothiophenyl, 3-tetrahydrothiophen-2-one, 4-tetrahydrothiophen-2-yl, 5-tetrahydrothiophene-2-keto, 2-tetrahydrothiophene-3-copper Base, 4·tetrahydrothiophene-3-olone, 5-tetrahydrogen. Steroid -3- 3-keto, 2-pyrrolidinyl, 3-pyrrolidinyl, 丨-pyrrolidone, 3-pyrrolidin-2-one, 4-pyrrolidine-2-one, 5-pyrrole Pyridin-2-one t S1 149026.doc •26- 201103429 base, 1-pyrrolidin-3-one, 2-pyrrolidin-3-one, 4-pyrrolidin-3-one, 5-° ratio Oops. D--3-keto, 1-D-Bisto-2,5-diketonyl, 3-. Ratio 0 pyridine-2,5-dione, 3-isoxazolidinyl, 4-isoxazolidinyl, 5-isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl , 5-isothiazolidinyl, 3-. More than ° ° ° base, 4 - ° ratio ° sit bite, 5 - ° than α sitting ° base, 2 -. evil. Sitting on the base, 4 -α evil. Sit σ foundation, 5 - ° evil. Sit D base, 2 - alpha plug. sit. Fixed base, 4-D plug. Sit π-base, 5-α plug. Sit σ base, 2 -. Rice α sits on the base, 4 - microphone. Αα定,1,2,4 -11oxadiazolidin-3-yl, 1,2,4-oxadiazolidine-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazolidine-5-yl, 1,2,4-triazolidine-3-yl, 1,3,4-oxadipine-2-yl, 1,3,4- °Sebutin-2-yl, 1,3,4-triseptin-2-yl, 2,3-di-rat alpha-furan-2-yl, 2,3-dinitrogen. Furan-3-yl, 2,4-di- 2, 2,4,2,2,2,2,2,2,2,2 Desphen-2-yl, 2,3-diaza α-sent-3-yl, 2,4-dimur. Cet-2-yl, 2,4-dinitrogen. Cephen-3-yl, 2-. Tbilisi-2 - base, 2 - 匕 咐 - 3 - base, 3 -.比 咐 咐 - 2 -yl, 3-pyrolin-3-yl, 2-isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl , 2-isoxazolin-4-yl, 3-isoxazolin-4-yl, 4-isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazole Benzin-5-yl, 4-isoxazolin-5-yl, 2-isothiazolin-3-yl, 3-isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-iso Thiazolin-4-yl, 3-isothiazolin-4-yl, 4-isothiazolin-4-yl, 2-isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-iso Thiazolin-5-yl, 2,3-dihydropyrazol-1-yl, 2,3-diaza D is more specific than salin-2-yl, 2,3-dinitrogen, sal-3-yl, 2, 3-dinitrogen. ratio. Sit-4-yl, 2,3 - 2 gas ratio ° sit -5-based, 3,4-dinitrogen. The ratio of -1 -yl, 3,4 -diaza 0 to σ sits on the -3-yl, 3,4-dihydrogen ratio. Sit-4-yl, 3,4-dihydro alpha ratio. Sit-5-based, 149026.doc -27- 201103429 4,5-dihydro D is more than sal-1--, 4,5-dihydro. ratio. Take -3 -yl, 4,5-dihydrogen. ratio. Sodium-4-yl, 4,5-dihydropyrazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrogen. Sodium-3-yl, 2,3-dihydro-deso-4-yl, 2,3-dihydro oxime. Sitting on a 5-based, 3,4-dihydrogen. Sitting 2-yl, 3,4-dihydrogen. Cacao-3-yl, 3,4-dihydrogen. -4-yl, 3,4-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydro oxazol-3-yl, 3,4 - Dihydrogen. Sit-4 - base, 2 - mother. Stationary, 3-branched bite base, 4-° bottom π-group, 1,3 -di-α-carbo-5-yl, 2-tetrazole α-pyranyl, 4-tetrahydronaphthyl, 2-tetrahydro . Steenyl, 3-hexahydroindole, 4-hexahydropyridazinyl, 2-hexahydro. Close bite, 4-hexahydro-dense. Stationary, 5-hexahydro-density, 2-0 thiol, 1,3,5-hexamol-2, and 1,2,4-hexanitrodiin-3-yl and corresponding - Subunit; a 7-membered saturated or partially unsaturated heterocyclic ring containing 1, 2 or 3 heteroatoms from a group consisting of oxygen, nitrogen and sulfur as ring members: for example, a single ring having 7 ring members And a bicyclic heterocyclic ring which, in addition to a carbocyclic member, also contains from 1 to 3 nitrogen atoms and/or an oxygen or sulfur atom or one or two oxygen and/or sulfur atoms, for example, tetrahydronitride And hexahydroazinyl, such as 2,3,4,5-tetrahydro[1Η]azepine-1-, -2-, -3-'-4-'-5-, -6- or -7- Base, 3,4,5,6-tetrahydro[2Η]azepine-2-, -3-, -4-, -5-, -6- or -7-yl, 2,3,4,7- Tetrahydro[111]azepine-1-'-2-,-3-, -4-, -5-, -6- or -7-yl, 2,3,6,7-tetrahydro[1Η]nitrogen -1--1- ' -2- ' -3-, -4-, -5-, -6- or -7-yl, six rat snorkeling -1, -2-, -3 - or -4 -yl , tetraazepine and hexahydrooxo group, such as 2,3,4,5-tetrahydro[1Η]oxo-2-, -Β-λ-4-, -5-, -6- or - 7-yl, 2,3,4,7-tetrahydro[1Η]oxo-2-,-3-,-4-,-5-,-6- Or 7-yl, 2,3,6,7-tetranitro[1Η]oxo-2-,-3-[S] 149026.doc • 28 - 201103429 or ·7-based, hexahydroxine _1 -4- -2- Discussing - -3- or _4-yl 'tetra- and hexachlorourethane sigma, azohime, tetra- and hexahydro-indole-diazol, four- and six Gas-1 3 - 〇亚急成盆,心氮千基,四- and hexahydro-Μ-oxazolyl group, four· and six winds _ 1 3 ·-Feikou Wuhe And hexahydro-1,4-dioxole and the corresponding -subunit. The dry soil contains 1, 2 or 3 5- or 6-membered aromatic (=maximum unsaturated) heterocyclic rings (=heteroaromatic groups) selected from heteroatoms consisting of oxygen, nitrogen and sulfur, for example, 5_Μ hetero-aryl which is bonded via carbon and which contains (1) a nitrogen atom or a nitrogen atom and a sulfur or oxygen atom as a ring member, such as 20-denyl, 3-furyl, 2-thienyl, thiothienyl, anthracene Pyrrolyl, 3-pyrrolyl, 3-isoxazolyl, 4-isoxazolyl, 5-isoxazolyl, %isothiazolyl, 4-isothiazolyl, 5-isothiazolyl, 3-pyrazolyl , 4_pyrazolyl 5-. ratio. Sitting on the base, 2 - ° evil. Sitrate, 4 - ° oxalyl, 5 - ° oxalyl, 20 oxazolyl, 4-thiazolyl, 5-thiazolyl, 2-imidazolyl, 4-imidazolyl, 1,2,4- Diazole-3-yl, 1,2,4-oxadiazol-5-yl, 1,2,4-thiadiazole-3-yl, 1,2,4-thiadiazol-5-yl, 1, 2,4-triazol-3-yl, 1,3,4-oxadiazole 2-yl, 1,3,4-thiadiazol-2-yl and 1,3,4-triazole-2-yl; 5-membered heteroaryl, which is attached via nitrogen and contains 1 to 3 nitrogen atoms as ring members,

Such as '11 bilo-1 -yl, α than sal -1 _ group, taste saliva-1 _ group, 1,2 3 _ = J 5 —' σ _ 1 yl and 1,2,4-triazole a -1- group; a 6-membered heteroaryl group having 1, 2 or 3 nitrogen atoms as a ring member, such as a pyridine-2-yl group, a pyridin-3-yl group. Than 疋-4 - &, 3-哒 secret, 4-哒 reduction, 2_like &, 4-mouth. Stationary, 5" dense 11-based, 2-pyrazinyl-1,3,5-triazin-2-yl and 1,2,4-triazinyl-3-yl; linear C2 or C3 alkylene: Divalent unbranched of 2 or 3 carbon atoms 149026.doc -29· 201103429 Chain, ie ch2ch2 and ch2ch2ch2. Linear CrC5 alkyl: a divalent unbranched bond having 1 to 5 carbon atoms', ie ch2 , ch2ch2, ch2ch2ch2, ch2ch2ch2ch2& ch2ch2ch2ch2ch2. C2-(:5): a divalent branch having 2 to 5 carbon atoms or preferably an unbranched chain, such as CH2CH2, -CH(CH3)-, ch2ch2ch2, ch( Ch3)ch2, CH2CH(CH3), CH2CH2CH2CH2, CH2CH2CH2CH2CH2. CU-Cs alkylene: a divalent branch having 4 to 5 carbon atoms or preferably an unbranched chain, such as CH2CH2CH2CH2 or ch2ch2ch2ch2ch2. The group-SM is more precise. The group is -S-M+, wherein M+ is a metal cation equivalent or a cation as defined above. The metal cation equivalent is more specifically 1/a Ma+, where a is the valence of the metal and is generally i. 2 or 3. The following statements regarding suitable and preferred characteristics of the compounds of the invention, especially with respect to their substituents Het, A, Y, Ri, R2 R3, r4, r5, r6, R6a, R7, R8, R9, Ri., R丨丨, ri2, Rl3, Rl4, Rl5, r, 6, statements about their use per se and especially in all possible combinations with each other Both are valid.

Het is preferably attached to the group γ via a C atom. In a preferred embodiment of the present invention, Het is a 5- or 6-membered heteroaryl ring containing, 2 or 3 hetero atoms selected from the group consisting of ruthenium, osmium and S as ring members, wherein the heteroaryl ring may be There are 1, 2, 3 or 4, preferably _, substituted filaments 5. More specifically, Het preferably contains i heteroatoms selected from N, oxime and § and as appropriate 149026.doc

[SI • 30· 201103429 Conditional 1 or 2 other nitrogen atoms 7 butyl as a 5- or 6-membered heteroaryl ring of the ring-shaped shell, wherein the hetero-aromatic ring can be 1 ancient! /, Yes, 2, 3 or 4, preferably 1 or 2 substituents R are listed above as suitable 5 or 6-membered heteroaromatic groups. Among the heteroaryl rings exemplified above, a mercapto group such as a K-2-yl group, a pyridin-3-yl group or a pyridyl-4-yl group; a pyrimidinyl group such as a 2-pyrimidinyl group, a 4·pyrimidin or a legal group is preferred. a furyl group such as 2-furyl or 3·furanyl; a thiol group such as 2-thienyl or 3-thienyl; a pyrrolyl group such as a pyrrolyl group, a 2-meryl group or a 3, yl group , especially 2_吼洛基 or 3_吼基基... than a sitting group such as 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl or 5-pyrazolyl, especially 3 than sitting, 4- Pyrazolyl or 5-pyrazolyl; imidazolyl, such as dipyridyl, succinyl, 2, merionyl or 4+, especially 2 mercapto or 4 acetonyl; oxazolyl, such as 2 -oxazolyl, 4-oxazolyl or 5-oxazolyl; isoxazolyl 3 isoxazolyl, 4-isoxazolyl or % isoxazolyl; thiazolyl such as 2-thiazolyl, 4-thiazolyl or 5-thiazolyl; isothiazolyl, such as 3-isothiazolyl, 4-isothiazolyl or 5-isothiazolyl; and triazolyl, such as 1,2,4-trisal_1 Base, oxime, 2, heart triazole _3_ group, triazole·' group, 1,3,4_three° siting base, 1,3,4-triazol-2-yl or 1,3,4 - triazol-3-yl, especially 1,2,4 · Triazol-3-yl or i,3,4-triazole_2-yl. The specified position of attachment is understood to be relative to the position of the heteroatom of the ring and has the highest priority. For example, a, contains 1 ring In the ring of a hetero atom, the position of the connection is specified relative to the i-position of the only-nuclear hetero atom. In the pyrazolyl group, the position of the connection is specified relative to the 氮_ and 2_ positions of the two nitrogen atoms, in the imidazolyl group. , specifying the position of the linkage relative to the 1- and 3-positions of the two nitrogen ring atoms. In the oxazolyl group, the position of the attachment is relative to the position of the oxygen ring atom and the position of the nitrogen ring atom at the 3_ position, in the different 149026. Doc 201103429 In the oxazolyl group, the position of the bond is specified relative to the 丨_position of the oxygen ring atom and the 2-position of the nitrogen ring atom. In the sold oxime group, the specified connection position is relative to the sulphur ring: the W stand and the nitrogen ring The position of the atom is in the same position as the pyridine group. a pyridine-3-yl or pyridyl group; a thienyl group such as a 2- or 3-thienyl group; and a thiazolyl group such as a 2-thiazolyl group, 4- "Sitting base or 5-s. Sitting base. Especially preferred is a thiol base such as pyridin-2-yl, pyridin-3-yl or pyridin-4-yl, and especially pyridine-2. In the case where Het is a 6-membered heteroaryl ring, it preferably has fluorene, fluorene, 2 or 3, more preferably 0, 1 or 2 substituents R5, wherein two or more substituents R5 may be the same Or different. In the case of 11-membered 5-membered heteroaryl ring, it preferably has fluorene, 1 or 2 substituents R5, wherein the two substituent bases 5 may be the same or different. R5 may be linked via C or N' However, it is preferably attached to the c atom of Het. R5 is preferably selected from the group consisting of halogen, OH, SH, N〇2, CN, CVC4 alkyl, CrCj alkyl, CVC4 alkoxy-CVC4 alkyl, Ci-C4 alkoxy, C,-C4 alkoxy-CrC4 Alkoxy and Ci-C^haloalkoxy, more preferably selected from the group consisting of fluorine, chlorine, bromine, (VC4 alkyl, (: 丨-(: 4-haloalkyl, alkoxy, and 匕-halo alkoxy) Even more preferably selected from the group consisting of fluorine, gas, bromine, CH3, chf2, CF3, OCH3, OCHF2 and 〇cf3' and especially selected from the group consisting of fluorine, gas, bromine, CH3, CF3, och3 and ocf3. From Het.l to Het.49 below:

t SI 149026.doc -32- 201103429 α # Λ

Ν

Het.1 Het.2 Het.3 Het.4 Het.5 Het.6 Het.7 Het.8

Άτϋ# A# /

H3CCT ▽ F3C (T v "Cl', ^ Br', ^ H3C', ^ H3CO

Het.9 Het.10 Het.11 Het.12 Het.13 Het.14 Het.15 Het.16

Het.17 Het.18 Het.19 Het.20 Het.21 Het.22 Het.23 Het.24

Het.39 Het.40 Het.41 Het.42 # # # # # #

Het.43 Het.44 Het.45 Het.46 Het.47 Het.48 Het.49 Among the above formulas, preferred groups are Het. 1 and Het. 4 to Het. 42, more preferably Het. .l and Het. 4 to Het. 24, and particularly preferably Het. 1, Het. 8, Het_12, Het. 19 and Het. In a preferred embodiment of the invention, R1, R2, R3 and R4 are independent of each other. • 33·149026.doc 201103429 is selected from the group consisting of nitrogen, a physin, 〇H 'SH, N02, CN, C, -C4 alkyl 'C|. C4 haloalkyl, Cl_c4 alkoxy·CrG alkyl, Ci_c&oxy, alkoxy-c^-c:4 alkoxy&Cl_C4 dentateoxy, more preferably selected from hydrogen, Fluorine, gas 'bromo, C】-C4 alkyl, Cl-C4 alkyl, c _c4 alkoxy and ^-^ halogen alkoxy, even more preferably selected from the group consisting of hydrogen, fluorine, gas, bromine, ch3, Chf2, CF3, 〇ch3, 〇CHFj OCF3, and especially selected from the group consisting of hydrogen, fluorine, gas, bromine, CH3, cf3, 0CH3 and ocf3. In a further preferred embodiment of the invention, 2, 3 or all 4 of Ri, R2, RW are hydrogen and the remaining groups Ri, R2, R3 and R4 are selected from the group consisting of halogen, OH, SH' N〇 2. CN, CVC4 alkyl, CVC4 dentate, G-C4 alkoxy-CVC4 alkyl, (VC4 alkoxy, CVC4 alkoxy-C, -C4 alkoxy and CVC4 haloalkoxy, more Preferably selected from the group consisting of fluorine, gas, bromine, Ci_c4 alkyl, Ci-C4 haloalkyl, CVC4 alkoxy and (^-(: 4-haloalkoxy, even more preferably selected from the group consisting of fluorine, gas, bromine, methyl, Ethyl, CHF2, CF3, methoxy, ethoxy, OCHF2 and OCF3, and especially selected from the group consisting of fluorine, chlorine, bromine, CH3, cf3, 0CH3 and OCF3. Even better, 3 of R1, R2, R3AR4 or All four are hydrogen and the remaining groups R1, R2, R3 or R4 are selected from the group consisting of halogen, OH, SH, N02, CN, (VC4 alkyl, Cl-C4 halogen-based 'Cl_c4 alkoxy-CVC4 alkyl , CVC 4 alkyl fluorenyl, CVC 4 alkoxy-c, -c 4 alkoxy and CVC 4 haloalkoxy' are more preferably selected from the group consisting of fluorine, gas, bromine, (^-(^ alkyl, C "C4 haloalkyl", CrC4 alkoxy group and fluorene alkoxy group, even more preferably selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, CHF2, CF3, methoxy, B The oxy 'OCHF2 and 〇CF3' are especially selected from the group consisting of fluorine, chlorine, bromine, ch3, CF3, 〇CH3 and ocf3. In particular, Ri, R2, ruler 3 and ruler 4 are hydrogen or r2, 149026.doc • 34 - 201103429 R3 and R4 are hydrogen and R1 is not hydrogen and is preferably selected from the group consisting of halogen, OH, SH, N〇2, CN, CVC4 alkyl, CVGi alkyl, alkoxy-(VC4 alkyl, CVQ alkoxy alkoxy-CVC4 alkoxy and heart-and-haloalkoxy, more preferably selected from the group consisting of fluorine, gas, bromine, CVC4 alkyl, CVC4 haloalkyl, Crq alkoxy and haloalkoxy, even better Selected from fluorine, gas, bromine, methyl, ethyl, CHF2, CF3, methoxy, ethoxy, ochf2 and ocf3, especially selected from the group consisting of fluorine, gas, bromine, ch3, cf3, och3 and ocf3 and especially In particular, the combined meaning of R1, R2, R3 and R4 is selected from the following combinations compiled in Table 1: Table 1

No. R1 RJ R4 1. Η HHH 2. Η FHH 3. Η Cl HH 4. Η Br HH 5. Η ch3 HH 6. Η CH2CH3 HH 7. Η chf2 HH 8. Η cf3 HH 9. Η OCH3 HH 10. Η OCH2CH3 HH 11. OC OCHF2 HH 12. Η OCF3 HH 13. FHHH 14. C1 HHH 15. Br HHH 16. ch3 HHH 17. CH2CH3 HHH 18. chf2 HHH 19. cf3 HHH 20. OCH3 HHH 21. OCH2CH3 HHH 22. OCHF2 HHH 23. OCF3 HHH 24. FFHH 25. HFHF 149026.doc -35- 201103429

Edit Rk R2 R3- R5 26. Η FFH 27. FHFH 28. Cl Cl HH 29. Η ~Cl ' H Cl 30. Η Cl Cl H 31. Cl H Cl H 32. F Cl HH 33. Cl FHH 34. HFH Cl 35. FH Cl H 36. H Cl ' FH 37. HF Cl H 38. CH3 CH3 HH 39. H CH3 H ch3 40. H CH3 ch3 H 41. ch3 H ch3 H 42. F CH3 HH 43. CH3 FHH 44. HHCH3 F. 53. HH3. HF 〇CH, H 54. FFFH 55. R12 in the FFHF group -C(=0)R12 and -S(0)2r12 is preferably selected from the group consisting of Ci_c4 alkyl, C"C2 halo, CVC4 alkoxy , Ci-C2 haloalkoxy, phenyl, phenoxy and NR R ' are more preferably selected from the group consisting of C1-C4, C^-Ca halo, qC alkoxy, C"C2 haloalkoxy" NR15R16, and even more preferably selected from (:_(: alkyl, C"C4 alkoxy and NR15R16. In the group -C(=〇)r12, r12 is especially C^-C4 alkyl, such as fluorenyl , ethyl, propyl, isopropyl, n- ortho, isopropyl butyl, t-butyl, isobutyl or tert-butyl, preferably C1-C4 oxygenated The base is as far as methoxy, ethoxy, propoxy 149026.doc -36-201103429, n-butoxy, 坌-s first butoxy, isobutoxy or tert-butoxy Preferably, 2 is a methoxy group, and more particularly a methyl group, and in the group _s(9) pentane 12, R is especially a methyl group. Preferably, R15 is hydrogen and R16 is selected from hydrogen, Ca alkyl and phenyl. 'preferably selected from hydrogen and C〗 _C4 alkyl; or r15 and r16 are

Cl-C4 alkyl, preferably methyl or ethyl. Preferably, the cerium is selected from the group consisting of a metal cation, a metal cation equivalent, a cation equivalent of Cu, Zn, Fe or Ν, or an ammonium cation of the formula (NRaRbRCRd)+, wherein one of the compounds is chlorine and Three of ^, ^^ & Rd are independently selected from C|-C1G alkyl. More preferably, the river system is selected from a cation equivalent of Li+, Na+, K+, y2Mg2+ 'Cu, Zn, Fe or Ni, or an ammonium cation of the formula (NRaRbRCRd)+, wherein one of Ra, Rb, Rc & Rd It is hydrogen and three of Ra, Rb, ... and Rd are independently selected from CVCw alkyl groups. Even more preferably, the M system is selected from the group consisting of Na+, K+, 1/2Mg2+, !/2Cu2+, ZZn2·", i/2Fe2+, i/2Ni2+, triethylammonium, and triammonium. In the group of formula III, the variables preferably have the same meaning in the remainder of molecule I. Therefore, the above statement regarding the preferred meaning of the group applies to this part as well. R6 is preferably selected from the group consisting of hydrogen, alkyl, -C(= 〇)R12, -S(C〇2Ri2, •CN, hydrazine, and a group of formula III, wherein R12 has the above general meaning or in particular One of the preferred meanings, and one of the above general meanings, or especially one of the above preferred meanings. R6 is more preferably selected from the group consisting of hydrogen, CVC4 alkyl, C3-C4 alkylcarbonyl, Cl-. a C4 alkoxycarbonyl group, an alkyl group, a -C(=0)N(C 丨-C4 alkyl group) 2, a Cl_ CU alkyl sulfonyl group, a CN, a hydrazine, and a group of the formula III, wherein hydrazine has the above - 149026. Doc •37· 201103429 One of the general meanings, or especially one of the above preferred meanings. In particular, R6 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, isopropyl, methyl a group of oxime oxycarbonyl, -c(=o)n(ch3)2, CN, M and formula (1), wherein hydrazine has one of the above general meanings, or especially one of the above preferred meanings, Preferably, R6 is a hydrogen methyl group, a methyl group, a methoxy group, a Na+ group or a hydrazine group. R6a is preferably selected from the group consisting of hydrogen and Cl-Cl0. Alkyl, Ci_C4 functional alkyl, phenyl, stupid-Ci-C4 alkyl -C( = 0)R12 and -s(〇)2Rl2, wherein r12 has one of the above general meanings, or particularly one of the above preferred meanings. More preferably, the system is selected from the group consisting of hydrogen and Cl-C4. a base, a Ci_C4 functional group, a phenyl group, a benzyl group, -(:(=0)!^2, and _8(〇) 21112', wherein Rl2 has one of the above general meanings, or especially the above preferred meanings One of them is more preferably selected from the group consisting of hydrogen, c=c4 alkyl, Cl_c4_alkyl, _c(=〇)Rl2&_s(〇)2Ri2, wherein R12 has one of the above-mentioned general meanings or particularly preferred One of the meanings. R "especially hydrogen, Cl_C4, (preferably fluorenyl) or c( 〇)R, more particularly hydrogen, Cl_C4 alkyl (preferably fluorenylmethyl or methoxycarbonyl) 'Especially more hydrogen or alkyl (preferably methyl)' is especially hydrogen. Y is preferably 〇. 'A is preferably a linear chain-stretching bridge, of which 2 The argon atom may be replaced by 1 or 2 substituents, each of which is independently selected from the group consisting of q-c4 alkyl, Cl_C4, Ci_coxy, alkoxy-c, -C4 alkoxy and oxime-匚4 haloalkoxy, and preferably selected from methyl, ethyl, decyloxy, B And the methoxymethoxy group is attached to the adjacent carbon source; [S1 149026.doc -38- 201103429 Two substituents R7 together with the carbon atom to which they are attached form a cyclopentyl or cyclohexyl ring. More preferably, 'A is a straight chain (^2 or (2) alkyl bridge in which one hydrogen atom of the alkylene bridge can be substituted with one substituent R7, wherein R7 is a C1-C4 alkyl group. Even more preferably, A is a linear (32 alkylene bridge wherein the hydrogen atom of the alkylene bridge can be replaced by one substituent R7, wherein R7 is a group and preferably a methyl group. More specifically, A is -CH(CH3)-CH2-. If m is 1, the oxygen atom is preferably bonded to the sulfur atom via a double bond, whereby the group -S(0)m-R6 forms a group _8 (=〇) Preferably, both oxygen atoms are attached to the sulfur atom via a double bond, whereby the group _s(〇)m_R6 forms a group -S(= 〇)2_r6. If 111 is 3, the group _s(〇)m_R6 is a group -S(= 〇)2-〇-R6 〇m is preferably 0 or 2 and more preferably ο. In a particularly preferred embodiment, 'in the compound work, 11 is 116 and 116 is Η (or otherwise 'in compound II, R6^H). The specific compound I/II is as follows: 2_{4_曱基~2-[2·曱基_4«咬_2-base gas Base)_stupyl H1,3_dioxol-2-ylmercaptotriazole_3_thiol; 2-{4-mercapto-2-[2-indenyl_4_(5-three曱 _ _ D 啶 J 基 基 基 基 基 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 3- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- 2- Mercapto-2-[4-(5-aza-3-fluoro)pyridyloxy)_2.methyl·phenylindole, 3-dioxolone曱基基b 2_Η,π,2,4]triazole thiol; 2-{4-mercapto-2·[4-(3,5-dichloroindol-2-yloxy)·2_methyl_ Phenyl]_149026.doc •39· 201103429 [1'3^heterocyclic m-methyl}-2-indole-[1,2,4]tris-trithiol; {2 [4-(3 - gas-5-dimethylmethyl.. ratio. _2_yloxy)2_methyl-phenyl]· cardiomethyl-[1,3-dioxol-2-a Base}2_, ie, 2(4) Sanjun_3_ mercaptan; 2-{2-[4-(5-chloro-3-fluorol-dioxolan-2-ylmethylj.din-2-yl) Oxy)-phenyl]-4-mercapto-[1,3-'2-H-[1,2,4]triazole-3-thiol. Examples of preferred compounds I and II are formula 1.1 to 1.96 and II.1 to 11.48 of the compound 'wherein the variable has one of the general meanings or especially preferred meanings given above. Examples of preferred compounds are the individual compounds compiled in the following Tables to 4176. As described below for individual variables in the table

The meaning itself (without relying on a combination of such variables) is a preferred embodiment of the relevant V base.

149026.doc 40· 201103429

149026.doc -41 - C: 201103429

[s] 149026.doc • 42-201103429

149026.doc 43- 201103429

[si 149026.doc 44- 201103429 R4

R4

R4

149026.doc •45- 201103429

One-o

[SI 149026.doc -46- 201103429

149026.doc • 47· 201103429

149026.doc •48- 201103429

149026.doc -49- 201103429

R6*

Table 1 Compounds of formula 1.1 wherein R3 and R4, wherein the combination of compounds Het, R1, R2, in each case corresponds to one of Table A and R6 is Η Table 2 R3 and R4 of formula L1, wherein the compound Het , R1, R2, in combination with a compound of formula L1 in each case corresponding to one of the columns of Table A and R6 being a fluorenyl group 3 R3 and R4, wherein the combination of Het, R1, R2 of the compound corresponds in each case to the table A column of A and R6 is a compound of the formula 1.4 149026.doc [•50· 201103429, wherein the combination of Het, Ri, R2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6 is The compound of the formula 1.1 wherein the combination of the compounds Het, R丨, r2, R3 & R4 corresponds in each case to one of the columns of Table A and R6 is an isopropyl group of the compound of the formula L1, wherein the compound The combination of Het, R1, R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6 is a compound of the formula butyl N, wherein the combination of Het, R丨, R2, R3 and R4 of the compound is In each case, it corresponds to one of the columns of Table A and R6 is the second butyl group. The compound of formula 1,1 'Het, R of the compound The combination of 丨, R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6 is an isobutyl group of the compound of the formula 9 wherein the compounds are Het, R1, R2, R3 and R4, and the mouth is in each case. A compound corresponding to one of the columns of Table A and R6 is a third butyl group 1 0 ^ I 1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the column of Table A and R6 For phenyl table 11

I: A compound of T, wherein the compounds of Het, R丨, r2, R3 and R4 correspond in each case to one of the columns of Table A and R6 is a benzyl group. 12 149026.doc -51 - 201103429 Compound of formula M Wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds to one of the tables A in each case and R6 is a compound of the formula M, wherein the compounds are Het, Ri, R2, R3 and R4. Combining in each case corresponds to a column of Table A and R6 is a compound of formula 1, formula 1, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 K+ is a compound of the formula M wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is 1/2]y [g2+ the compound of the formula L1, Wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and the ruler 6 is !/2 (: 112 + Table 17 Compound of Formula 1 wherein the compound is Het, R1, R2 The combination of R3 and R4 corresponds in each case to one of the columns of Table A and the ruler 6 is 1/2 Zn2+. The compound of the formula L1, wherein the compounds are Het, R1, R2, R3 and R4 A group of Het, R1, R2, R3 and R4 of the compound corresponding to the compound of the formula y2Fe2+, wherein each of the compounds corresponds to one of the columns of Table A, and in each case corresponds to one of the columns of Table A and R6. For ZNi24 Table 20

[SI 149026.doc 52- 201103429 A compound of formula 1,1 wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is NH(CH3)3+ A compound of the formula L1, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is NH(C2H5)3+ wherein the compound of the formula L1, wherein the compound is Het The combination of R1, R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6 is nh(ch2ch2ch2)3+ the compound of the formula 1.1 in Table 23, wherein the combination of Het, R1, R2, R3 and R4 of the compound In each case, corresponding to one of the columns of Table A and R6 is NH(CH(CH3)2)3 + Table 24 Formula L1, wherein the combination of Het, Ri, r2, R3 and R4 of the compound corresponds in each case to A column of Table A and R6 is nh(ch2ch2ch2ch2)3+ Table 25 Compound of formula I·1 'wherein the combination of compounds Het' R1, r2, R3 and R4 corresponds in each case to one of Table A and R6 is A The compound of formula 1.1 wherein the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6 is an ethyl carbon group. Table 27 Formula I · 1 The compound 'Het, R1, r2, r3 and r4 of the compound 149026.doc -53-201103429 combination in each case corresponds to one of the tables A and R6 is a propyl group of the compound of the formula 28·1 Wherein the combination of Het, R2, r3 & r4 of the compound corresponds in each case to one of the columns of Table A and R6 is an isopropyl group of the compound of the formula 1.1, wherein the compounds are Het, Ri, R2, R3 and R4 The combination in each case corresponds to one of the columns of Table A and R6 is a compound of the formula methoxy formula 30, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A. And R6 is an ethoxylated group of the compound of the formula 1.1 wherein the combination of Het, R丨, r2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6 is a propoxyl group. The compound 'in which the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6 is a compound of the formula I.1 of the isopropoxyl group, wherein the compound Het, R1 The combination of r2, r3 and r4 corresponds in each case to one of the columns of Table A and R6 is a combination of phenoxycarbonyl group 34 and formula I.1. Wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is a compound of the formula 1 of the methylaminocarbonyl group, wherein the compound is Het, R丨, R2 [S1 149026.doc •54-201103429, 'and 0 in each case corresponds to one of the tables A and R6 is an ethylaminocarbonyl group of the formula L1, wherein the compound iHet, The group of R1, R2, R3 and R4, in each case corresponds to one of the columns of Table A and R6 is a propylaminocarbonyl group, the compound of the formula U, wherein the compounds are Het, R1, R2, R3 and R4 The 'combination in each case corresponds to one of the columns of Table A and R6 is a compound of the formula isopropylamine carbonyl group, wherein the combination of Het, R, R2, R3 and R4 of the compound corresponds in each case to Column A and R6 is a phenylaminocarbonyl group. Compounds of formula L1 wherein the combination of Het, R1 'R2, R3 and R4 of the compound corresponds in each case to one of Table A and R6 is methylsulfonyl. Table 40 Compounds of formula L1 wherein the combination of Het, R1 'R2, R3 and R4 of the compound corresponds in each case to one of Table A and R6 is ethyl sulfonate. The compound of the formula L1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the column of Table A and R6 is a compound of the formula I.1 of the propionyl group, Wherein the combination of Het, Ri, R2, 3 and 4 of the compound corresponds in each case to one of the columns of Table A and R6 is a compound of the formula I.1, wherein the compound is Het, R1. 149026.doc -55- 201103429 of r2, r3 and r4 The combination corresponds in each case to one of the columns of Table A and R6 is a compound of the formula L1, wherein the compounds are Het, R1, r2, R3 and The combination of R4 corresponds in each case to one of the columns of Table A and R6 is a compound of the formula methoxyl group, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the table. A compound of the formula A wherein R6 is an ethoxylated oxime group, wherein the combination of Het, R1, R2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6 is a propoxylated group. A compound of the formula 1.1, wherein the combination of Het, R1, r2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is isopropoxy A compound of the formula: wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is a phenoxysulfonyl group. The compound of the formula 1 wherein the compound The combination of Het, R], R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6 is CN. Table 50 to 98 Compounds of the formula 1.2 wherein the compounds are Het, r丨, R2, 3 and R4 The combination corresponds in each case to one of the columns of Table A and R6 is as defined in any of Tables 1 to 49, tables 99 to 147 149026.doc

t SI -56· 201103429 A compound of formula L3 wherein the combination of Het, Ri, R2, 3 and 4 of the compound corresponds in each case to the list of Table A and R6 is as in any of Tables i to 49. The compounds of formula 148 to 196 are defined in the formula, wherein the combination of Het, R1, R2, ... and 4 of the compound corresponds in each case to one of the columns of Table A and R6 is as in any of Tables} to 49. The compounds of formula 197 to 245, formula L5, wherein the combination of Het, R1, R2' and the ruler 4 of the compound correspond in each case to one of the columns of Table A and R6 is as in Tables to 49. A compound of the formula L246, wherein the combination of Het, R1, R2, r3 and μ of the compound corresponds in each case to one of the columns of Table A and R6 is as defined in any one of Tables to 49. Tables 295 to 343 are defined as compounds of formula [7, wherein the combination of Het, R丨, R2, "and 4" of the compound corresponds in each case to one of Table A and R6 is as shown in Tables to 49. The compounds of the formulae 344 to 392 of the formula L8, wherein the combination of Het, Ri, R2, R3 and R4 of the compound corresponds in each case to the column of Table A and R 6 series as in the table! Any of the compounds of formula L9, wherein the combination of Het, R1, r2, R3 and 4 of the compound corresponds in each case to one of Table A and is defined in any one of the tables 393 to 441 149026.doc -57·201103429 R6 is a compound of the formula 442 to 490, formula 1.1, as defined in any one of Tables 1 to 49, wherein the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of Table A and R6 is a compound of formula 491 to 539, formula L11, as defined in any one of Tables 1 to 49, wherein the combination of Het, R1, R2, R3 & R4 of the compound corresponds in each case to one of Table A and R6 A compound of the formula 540 to 588 of the formula L12 as defined in any one of Tables 1 to 49, wherein the combination of Het, R2, "and 4" of the compound corresponds in each case to one of the columns of Table A and the R6 system The compounds of Tables 1.183 to 637 are as defined in any one of Tables to 49, wherein the combination of Het, ri, r2, R3 and r4 of the compound corresponds in each case to one of Table A and R6 is as Tables 638 to 686 are compounds of formula M4 as defined in any one of Tables 2 to 49, wherein the compounds are Het, R1, R2, R3 & R4 In each case, it corresponds to one of the columns of Table A and R6 is as defined in any of Tables i to 49. Tables 687 to 735 [S] 149026.doc -58- 201103429 Compounds of the formula 'Het, The combination of R1, r2, r3 and r4 corresponds in each case to one of the columns of Table A and R6 is as defined in any of Tables 1 to 化合物 compounds of the formula 736 to 784, wherein the compounds are Het, Rl The combination of R2, r3 and μ corresponds in each case to Table A. Column # is a compound of the formula 785 to 833 of the formula L17 as defined in any of Table 149, wherein the compound Het, Ri, r2 The combination of Rule 3 and Han 4 corresponds in each case to one of the columns of Table A and R6 is a compound of the formula 834 to 882 formula 1.18 as defined in Table 2 to 49, wherein the compound Het, Ri, r2 The combination of Han 3 and Rule 4 corresponds in each case to one of the columns of Table A and the rule 6 is as shown in Tables 丨 to 49 of 2, Table 883 to 931, the compound of the formula 1.19, in which the compound Het, Ri, R2 The combination of Han 3 and Han 4 corresponds to one of the eight tables in each case and r6 is as defined in any of the tables 932 to 980. The compound of .20, wherein the combination of the compound Het, R], r2, amp 3 and han 4 corresponds in each case to one of the columns of Table 8 and R6 is as defined in any of Tables 981. To 1029 149026.doc .59-201103429 A compound of formula 1.21 wherein the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6 is as in any of Tables 1 to 49. The compounds of formula 1.32 are defined in Tables 1030 to 1〇78, wherein the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of Table A and R6 is as shown in Tables i to 49. The compounds of the formulae 1.27 to 1127, formula 1.23, wherein the combination of Het, R1, R2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6 is as in any of Tables 1 to 49. Tables 1128 to 1176 are defined as compounds of formula 1-24, wherein the combination of Het, R1, r2, R3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6 is as in any of Tables i to 49. The compounds of the formula 1.25 to 1225 are defined in the formula 1.25 to 1225, and the combination of the compounds Het, r丨, 2 VIII and the combination thereof are in each case And a compound of the formula 1.26 to 1274, formula 1.26, as defined in any one of Tables i to 49, wherein the combination of Het, R丨, r2 'r3 & r4 of the compound corresponds in each case Listed in Table A and R6 is as defined in any of the Tables Tables 1275 to 1323 [S] 149026.doc • 60-201103429 Formula 1-27, wherein the compound Het, Ri, r2 d3 a ^4 ^ The combination of κ and κ corresponds in each case to one of the columns of Table A and the ultra 6 is as defined in any of Tables 1 to 49. Table 1324 to 1372 The compound of the formula 1.28, wherein the compound is Het, R! The combination of 2 'r3 and r4 corresponds in each case to one of the columns of Table A and R6 is a compound of the formula 1.37 to 1421 of the formula 1.29 as defined in any one of Tables 1 to 49, wherein the compound Het ' Ri, r2 The combination of '^ and ... corresponds in each case to one of the columns of Table 8 and R6 is a compound of the formula 1.42 to 1470 of the formula 1.30 as defined in any one of Tables i to 49, wherein the compound Het, ri, R2 The combination of Rw corresponds in each case to one of the columns of Table A and the ruler 6 is as defined in any of Tables 1 to 1147 to 1519. The compound of .31, wherein the combination of the compounds iHet, Ri, R2, R3 and μ corresponds in each case to one of the columns of Table A and the r6 is as defined in Tables 1520 to 1568. 1. The compound of 1.32 wherein the combination of Het, ri, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6 is as defined in any of Tables 1 to 1617 149026. Doc 201103429 The compound of formula 1,33, wherein the combination of Het, Ri, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and the ruler 6 is as defined in Tables 1618 to 1666 as defined in the phantom to one. A compound of formula 1.34, wherein the combination of compounds, r, R2, r3 and y, in each case corresponds to the column of Table A and R6 is as defined in Table 1667 to 1715 as defined in any of the fishing. A compound of formula 1,35 wherein the combination of Het, R1, R2, r3 & r4 of the compound corresponds in each case to one of the columns of Table A and Rule 6 is as defined in Table 1716 as defined in any of Tables 4949 to 1764 A compound of formula 1.36 wherein the combination of Het, R2, r3 and hydrazine of the compound corresponds in each case to one of the columns of Table A and R6 A compound of the formula L1, R1, R2, "and the ruler 4 of the compound, as defined in any of the above, wherein the combination of Het, R1, R2, "and the ruler 4 of the compound corresponds in each case to the column of Table 8 and R6 A compound of the formula L18, as defined in any one of Tables 1 to 5, wherein the combination of Het, R1, R2, R3 and r4 of the compound corresponds in each case to one of the columns of Table A and the R6 system A compound of the formula 1.39 to 1911 149026.doc m • 62-201103429, wherein the combination of Het, Ri, R2, r3 and r4 of the compound corresponds in each case, as defined in any of Tables 1 to 49. And the combination of Het, Ri, R2 '" and ^ of the compound in each case corresponds to each of the compounds of Tables 1912 to I960 as defined in any one of Tables i to 49. A column of Table A and R6 is a compound of the formula 1961 to 2009 formula 1.41 as defined in any one of Tables i to 49, wherein the compound is only a combination of 6{'1^1, 2, 2, and 4 In each case corresponds to one of the columns of Table A and R6 is as defined in any of Tables i to 49. Tables 2010 to 2058 Formula 1, 42 The combination of Het, R!, R2, Ruler 3 and Ruler 4 of the compound in each case corresponds to one of Table A and Rule 6 is as defined in Tables 20 to 2107 as defined in any of Tables 1 to 49. A compound of the formula '43 wherein the combination of Het, r|, r2, 尺3 and 尺4 of the compound corresponds in each case to one of the columns of Table A and R6 is as defined in any of Tables 至49 Tables 2108 to 2156 are compounds of the formula: wherein the combination of Het, Ri, r2, ..., and 4 of the compound corresponds in each case to one of the columns of Table A and R6 is as in any of Tables 1 to 49. Tables 2157 to 2205 149026.doc • 63- 201103429 Compounds of the formula 1.45, wherein the combination of compounds 1, 1 , 112, 113 and 114 corresponds in each case to one of the tables A and the R 6 is as shown in the table. The compounds of the formulae 2206 to 2254, formula 1.46, as defined in any one of 1 to 49, wherein the combination of Het, R1, r2, ..., and ^^ of the compound corresponds in each case to one of the columns of Table A and the R6 is as shown in the table. ! Tables 2255 to 2303, as defined in any one of the formulas of formula 1.47 to 2303, wherein the combination of Het, R1, R2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6 is as shown in Table 1 to The compounds of Tables 1.48 to 2352, formula 1.48, as defined in any one of 49, wherein the combination of Het, Ri, r2, ..., and 4 of the compound corresponds in each case to one of Table A and R6 is as in Table 1 to The compound of formula 1.49 as defined in any one of 49' wherein the combination of Het, Ri, R2, r3 and r4 of the compound corresponds in each case to a compound of the formula 2354, formula L5, wherein the compound The combination of Het, R1 'R2, R3 and R4 corresponds in each case to the compound of the formula L2, formula L51, wherein the compounds Het, R1, R2, rW, and & in each case correspond to One of the tables A t

149026.doc • 64 - 201103429 Table 2356 Compound of formula 1.52 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2357, formula 1.53, wherein the compound is Het, The combination of R1, R2, R3 and R4 corresponds in each case to the compound of formula 1.54, formula 1.54, wherein the combination of compounds Het, R1, R2, R3 and R4 corresponds in each case to one of Table A The compound of formula 1.55, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 2360, formula 1.56, wherein the compound is 1^1, 111, 112, The combination of 113 and 114 corresponds in each case to the compound of formula 2361, formula 1.57 of Table A, wherein the combination of compounds 1^1, 111, 112, 113 and 114 corresponds in each case to a list of Table A 2362 A compound of the formula 1.58, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 2, formula 1.59 of Table A, wherein the compounds are Het, R1, R2, R3 and R4 The combination corresponds to one of the columns in Table A in each case 149026.doc -65· 201103429 Table 2364 Compounds of formula 1.6, wherein the combination of only 61 and 1 of the compound corresponds in each case to the compound of formula 2365, formula 1.61, wherein the compound is Het, R丨, , in each case corresponding to the compound of the formula 2366, formula 1.62, wherein the combination of Het and R1 of the compound corresponds in each case to the compound of the formula 2367, formula L63, wherein the compound Het, R1 combination In each case corresponds to the compound of the formula L2 in the formula 2368, wherein the Het, R1 combination of the compounds corresponds in each case to the compound of the formula 2369, formula L65, wherein the compound Het, R1 is combined in each In the case of a compound of the formula 16.6, formula 1.66, wherein the compound Het, R1, in each case corresponds to the compound of the formula 237 1 formula 1.67, wherein the compound Het, R1 is combined In the case, R2 of R2, R3 and R4 of R2, R3 and R4, R2 of R3, R3 and R4, R2 of R3 and R4, R2 of R4 and R4 of R4, R2, R3 and R4 of R4 R2, R3 And R4 t S1 149026.doc -66- 201103429 Table 2372 Compound of formula 1.68, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2373, formula 1.69, of Table A, Wherein the combination of Het, R, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 2374, formula 1.70 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound is in each case Corresponding to a compound of the formula 2375, formula 1.71, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 2376, formula 1.72, wherein the compound Het, R1 The combination of R2, R3 and R4 corresponds in each case to the compound of the formula 2377 Formula 1.73 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to a list of Table A 2378 A compound of formula 1.74 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2.379, formula 1.75 of Table A, wherein the compounds are Het, R1, R2, R3 and R4 The combination corresponds to Table A in each case Column 149026.doc -67- 201103429 Table 2380 Compound of formula 1.76, wherein the combination of compounds Het, R1, R2, R3 and R4 corresponds in each case to the compound of formula 2.81, formula 1.77, wherein the compound is Het The combination of R1, R2, R3 and R4 corresponds in each case to the compound of formula 2.38, formula 1.78 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to Table A. A list of compounds of formula 2.39, formula 1.79, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2.38, formula 1.80 of Table A, wherein the compounds are Het, R1, R2, R3 and The combination of R4 corresponds in each case to the compound of formula 1.81, formula 1.81, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 1.82, formula 1.82, in Table A. , wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 1387, formula 1.83, wherein the combination of Het, R1, R2, R3 and R4 of the compound is in each case Corresponds to one of the tables [S1 1490 26.doc-68-201103429 Table 2388 Compounds of the formula 1.84, wherein the combination of the compounds "^, 111, 112, 113 and 114 corresponds in each case to the compound of the formula 2.85 of the formula A, wherein the compound Het The combination of R1, R2, R3 and R4 corresponds in each case to the compound of formula 1390, formula 1.86 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to Table A. A list of compounds of formula 1.87, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 1.88, formula 1.88 of Table A, wherein the compounds are Het, R1, R2, R3 and The combination of R4 corresponds in each case to the compound of formula 1.99 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2394, formula 1.90, of Table A. , wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of the formula 2395 * Formula 1.91 of Table A, wherein the combination of Het, R1, R2, R3 and R4 of the compound is in each case Below 'corresponds to one of the columns in Table A 149026.do c • 69- 201103429 Table 2396 Compound of formula L92 wherein the combination of Het, Ri, R2, R^R4 of the compound corresponds in each case to one of the compounds in Table 2397, formula L93, in which the compound Het, R1 The combination of R2, R3 and R4 corresponds in each case to the compound of the formula 1398, formula 1, 94, wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds in each case to Table A. A list of compounds of formula 1,399, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to the compound of formula 2400, formula L96, wherein the compound is Het, Ri, R2. The combination of R3 and R4 corresponds in each case to a compound of the formula 2, Formula 2, Formula 11, 1 wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds in each case to one of Table A and 1163 is 化合物 Table 2402 A compound of the formula 1.1, wherein the compound is Het, R1, R2, R3 and R4, and 〇 in each case corresponds to one of the columns of Table A and R6a is a fluorenyl group 2403 Formula Π.1 a compound wherein the combination of Het, r1, R2, R3 and R4 of the compound corresponds in each case to Table A And R6a is an ethyl group I49026.doc 201103429 Table 2404 A compound of the formula 1.1, wherein the combination of Het, ri, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and is a n-propyl form. 2405 A compound of the formula H.1, wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R& is a compound of the formula II. The combination of Het, Ri, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and is a compound of the formula 1-4, formula II.1, wherein the compounds are Het, R丨, r2, R3 and r4 The combination in each case corresponds to one of the columns of Table A and R6a is the second butyl group 2408. The compound of formula II.1 wherein the combination of Het, R丨, r2, r3 and r4 of the compound corresponds in each case to the table. One of A is an isobutyl group 2409. The compound of formula II.1 wherein the combination of Het, r1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6a is the third butyl table 2410. The compound of formula 1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to Table A And R6a is a compound of the formula phenyl group 2411, wherein 'the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is benzyl 149026.doc-71 · 201103429 Table 2412 Compound of the formula ,1, wherein the combination of Het, r1, r2 of the compound corresponds in each case to one of the columns of Table A and R6a is a compound of the formula 11 carbonyl of the fluorenylcarbonyl group 2413, wherein the compound Het, The combination of R1 'R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula E., wherein the combination of Het, Ri, R2, R3 and R4 of the compound is in each case Corresponding to a column of Table A and R6a is a propylcarbonyl group 2415, a compound of formula 11,1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is isopropyl. The carbonyl group of the compound of the formula IL1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is a phenyl group of the formula 2417. The compound of the formula II. The combination of Het, ri, r2, r3 and r4 corresponds to one of Table A in each case And R6a is a methoxycarbonyl group 2418. The compound of formula '.1 wherein the combination of Het, R1, R2, R3 and 4 of the compound corresponds in each case to one of the columns of Table A and R6a is ethoxycarbonyl. A compound of II-1 wherein the combination of Het, ri, r2, R3 and r4 of the compound corresponds in each case to one of Table A and R6a is propoxycarbonyl [S1 149026.doc • 72-201103429 Table 2420 Formula II. 1 a compound wherein the combination of Het, R1, r2, R3 and R4 of the compound corresponds in each case to the column of Table A and R6a is isopropoxycarbonyl. Table 2421 Compound of formula IL1 wherein the compound is Het, R1, R2 The combination of R3 and R4 in each case corresponds to one of the columns of Table A and R6a is a phenoxycarbonyl group. The compound of the formula 22.1, wherein the combination of Het 'R1, R2, R3 and R4 of the compound corresponds in each case. A compound of the formula A, wherein the combination of Het, R, R 2 , R 3 and R 4 of the compound corresponds in each case to one of the columns of Table A and is ethyl. Aminocarbonyl group 2424 A compound of formula 11, wherein a combination of Het, R1, R2, R3 and R4 of the compound In each case, corresponding to one of the columns of Table A and R6 a is a propylaminocarbonyl group 2425, a compound of the formula IL1 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the tables A and R6a is an isopropylaminocarbonyl group of the compound of formula 2626, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and is a phenylaminocarbonyl group. 2427 A compound of the formula 11 wherein the combination of Het, Ri, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R 6 a is sulfonyl 149026.dc -73- 201103429 Table 2428 A compound of the formula 11 wherein the combination of Het, ri, r2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is a compound of the formula 4291, 2, wherein the compound The combination of Het, R1, R2, R3 and R4 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula propylsulfonyl group 2430, wherein the compounds are Het, Ri, r2, R3 and R4 Combinations in each case corresponding to one of the columns of Table A and being a compound of the formula isopropyl sulfonyl group 2431 Π.1 The combination of Het, Ri, r2, R3 and R4 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula phenylsulfonyl group 2432, wherein the compound is Het, Ri, R2, and 4 The combination in each case corresponds to a compound of the formula A and is a compound of the formula oxime oxime 2433, wherein the combination of Het, Rl, r2, r3 and r4 of the compound corresponds in each case to Table A. And R6a is a compound of ethoxysulfonyl group 2434, π·ι, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of Table 8 and is propoxysulfonyl. Table 2435 Compound of the formula π.1, wherein the combination of Het, Rl, Μ, r3 and μ of the compound corresponds in each case to one of the columns of Table VIII and is isopropyl 氡 149 026.doc

[SI-74 · 201103429 Table 2436 Compounds of the formula 11] wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is a phenoxysulfonyl group. The compound of Π. 1, wherein the combination of Het, r1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R& is cn. Table 2438 to 2474 The compound of the formula II.2 'where the compound of the fjet The combination of R1, R2, 3 and R4 corresponds in each case to one of the columns of Table A and R& is a compound of the formula 2475 to 2511 of the formula Π.3 as defined in any of Tables 24〇1 to 2437. Wherein the combination of Het, R1, R2, Ruler 3 and Ruler 4 of the compound corresponds in each case to one of the columns of Table A and R is as defined in Tables 2512 to 2548 as defined in any of Tables 24 to 1437. A compound of the formula 44, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and R6a is as defined in any of Tables 24 to 1437. 2549 to 2585 A compound of the formula II.5 wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and the R& Tables 2586 to 2622, which are defined in any of Tables 2 to 2437, are compounds of the formula ,6, wherein the compound Het, R1, R2, Rw 149026.doc • 75-201103429 combination corresponds in each case to the table The column of A and the ruler 63 are the compounds of the formulas 2623 to 2659 of the formula ΙΙ7 as defined in any one of Tables 24〇1 to 2437, wherein the combination of Het, R丨, R2, R3 and R4 of the compound is In each case, corresponding to Table A, the column is "as shown in any of Tables 240A to 2437, and the compounds of Tables 2660 to 2696, 8 are compounds of Het, R丨, r2, R3 of the compound. And the combination of R4 in each case corresponds to one of the columns of Table A and the ruler "is a compound of the formula 2697 to 2733 of the formula Π·9 as defined in any of Tables 24〇1 to 2437, wherein the compound Het, R1 The combination of r2, R3 and R4 corresponds in each case to one of the columns of Table A and R is as defined in Tables 2734 to 2770, formula 1110, as defined in Tables 24〇1 to 2437, wherein the compound Het The combination of R1, R2, 尺3 and R4 corresponds in each case to the column of Table A and R is as defined in Tables 24〇1 to 2437. Tables 2771 to 2807 'R1, R2, R3 and R4 63 are as shown in Table 2401 to Formula 11, 11 in which the compound 'Het, the combination of which corresponds to each of Table A and Han 2437 in each case Tables 2808 to 2844 of the formula 11.12, wherein the combination of compound 1^, ruler 1, ruler 2, & 3 and ruler [.S] 149026.doc • 76- 201103429 corresponds in each case to Table A And a combination of Het 'R1, r2, r3 & r4 of the compound, in each case, as defined in any of Tables 24 to 1 and 2437. Corresponding to one of the columns of Table A and R6a is a compound of the formulas 2882 to 2918 of the formula 11.14 as defined in any one of Tables 24 to 1437, wherein the compounds are 11^, 11丨, 112, Han 3 and Han 4 Combining the compounds of Tables 2919 to 2955, Π.15, as defined in any of Tables 24〇1 to 2437, in each case, wherein fjet, Ri, r2, ruler 3 of the compound The combination of the ruler 4 corresponds in each case to one of the columns of Table A and the ruler 63 is as defined in any of Tables 2401 to 2437, Tables 2956 to 29 92. The compound of formula 11.16 wherein the combination of compound ^^, 111, 1^2, 尺3 and 尺4 corresponds in each case to one of Table A and is as in any of Tables 24A to 2437. Tables 2993 to 3029 are defined as compounds of formula 11.17, wherein the combination of 1^'111, 1^, 113 and 1^4 of the compound corresponds in each case to one of the columns of Table A and the ruler 63 is as shown in Table 24〇 Tables 3030 to 3066, defined in any one of 2437, are compounds of formula II.18, wherein the combination of Het, R1, r2, r3 and r4 149026.doc-77-201103429 of the compound corresponds in each case to Table A. The combination of tables 3067 to 3103 as defined in any of Tables 240 1 to 2437 in each case corresponds to the array of Table A and R6a is as in any of Tables 240 1 to 2437. The compounds of the formula IL20 are defined in Tables 3104 to 3140, wherein the combination of Het, R1, R2, Ruler 3 and R4 of the compound corresponds in each case to the list of Table A and the ruler is as in Tables 2401 to 2437. Tables 3141 to 3177 of the formula II.21, wherein the combination of Het, R丨, R2, R3 and R4 of the compound corresponds in each case to Table A. • Column 63 is a compound of the formula II.22 as defined in any of Tables 2401 to 2, 37, wherein the combination of Het, R1, r2, r3 and r4 of the compound is in each case Corresponding to one of the columns of Table A and R6a is a compound of the formulae 3215 to 3251, formula 11.23 as defined in any one of Tables 24 to 1437, wherein the combination of the compound 1^, the ruler 1, the ruler 2, the 113 and the 114 In each case, corresponding to one of Tables 8 and as defined in any of Tables 24〇1 to 2437, compounds of formulas 3252 to 3288, formula 11.24, wherein compounds iHet, Ri, R2, R3 and R4 ί 149026. The combination of doc •78-201103429 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula 28925, as defined in any of Tables 24A to 2437, wherein the compound Het The combination of R1, R2, r3 & r4 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula 32626 of Tables 3326 to 3362, as defined in any of Tables 24 to 2437, wherein The combination of Het, R, R2, Ruler 3 and R4 of the compound corresponds in each case to one of the columns of Table A and 1163 is as shown in Table 24〇1 Any of the compounds of formulas 3363 to 3399, Π.27, as defined in any one of 2,437, wherein the combination of Het, R1, R2, R3 and R4 of the compound corresponds in each case to one of Table A and Rea is as in Table MW a compound of the formula II.28, as defined in any one of 2437 to 3,436, wherein the combination of the compound, R1, R2, R3 and r4 corresponds in each case to one of the columns of Table A and the R& Tables 3437 to 3473 are compounds of the formula 29.29 as defined in any one of Tables 24 to 3, wherein the combination of Het, R1, R2, r3 and μ of the compound corresponds in each case to the expression - And R "is a compound of the formula 3474 to 3510 of the formula Π·30 as defined in any of Tables 24 to 1437, wherein the compounds are Het, R1, R2, ... and ana 4 149026.doc -79- The combination of 201103429 corresponds in each case to one of the tables A and the ruler 6& is as defined in Tables 2401 to 2437, as defined in Tables 3511 to 3547, the compound of the formula II.3.1, wherein the compound j|et, The combination of R1, r2, r3 and r4 corresponds in each case to one of the columns of Table A and R6a is as defined in Tables 24A to 2437, as defined in Tables 3548 to 3584. A compound of the formula 11.32, wherein the combination of Het, R1, r2, r3 and r4 of the compound corresponds in each case to one of the columns of Table A and R6a is as defined in Table 3585 as defined in any of Tables 24 to 1437. 3621 A compound of the formula 33 wherein the combination of Het, R1, r2, R3 and R4 of the compound corresponds in each case to one of the columns of Table A and Rea is as defined in any of Tables 24 to 2437. Tables 3622 to 3658 Compounds of the formula 34.34 wherein the combination of Het, Ri, R2, ampule 3 and R4 of the compound corresponds in each case to one of the columns of Table A and Rea is as in any of Tables 24 to 1437. The compounds of the formula II.35 are defined in Tables 3659 to 3695, wherein the combination of Het, size, r2, and Rw of the compound corresponds in each case to one of the columns of Table A and the ruler 63 is as shown in Tables 24i to 2437. Any of the compounds of Tables 3696 to 3732, wherein 组合36, wherein the combination of compounds Het, Ri, R2, R3, and R4 [S] 149026.doc 201103429 corresponds in each case to one of Table A and The ruler "is a compound of the formulas 3733 to 3769 of the formula II.37 as defined in any of the forms 2401 to 2437, wherein the compound is fjet, r 1. The combination of ruler 3 and r4 corresponds in each case to one of the columns of Table A and 1163 is a compound of the formula 3770 to 3806 of the formula ΙΙ·38 as defined in any of Tables 2401 to 2437, wherein the compound Het The combination of Ri, r2, r3 & r4 corresponds in each case to one of the columns of Table A and R6a is a compound of the formula 3807 to 3843 of the formula Π.39 as defined in any of Tables 24i to 2437, wherein The compounds Het, Ri, R2, R3 and R4 of .. and & in each case correspond to one of the columns of Table A and R6a is as shown in Table Μ. The compounds of Tables 1844 to 3880, Formula 11.40, as defined in any of 1 to 2437, wherein the combination of Het, R1, R2, 仗3 and Han 4 of the compound corresponds in each case to one of Table A and Rfia is as in The compounds of the formulae 3881 to 3917, formula 11.41, as defined in any of Tables MW to 2437, wherein the combination of Het, R丨, r2, & 3 and 4 of the compounds corresponds in each case to one of the tables A and 63 is a compound of the formulae 3918 to 3954, formula 11.42, as defined in any one of Tables 24 to 1437, wherein a combination of Het, R1, r2, r3 and r4 149026.doc • 81 - 201103429 of the compound is in each case. The following corresponds to a column of Table A and the ruler "is a compound of the formulas 3955 to 3991, formula 11.43 as defined in any of Tables 2401 to 2437, wherein the combination of Het, R1, r2, and Rule 4 of the compound is in each case. The following corresponds to a column of Table A and the ruler "is a compound of the formula 399. In each case corresponds to one of the columns of Table A and is as defined in any of Tables 24〇1 to 2437, Table 4029 4065 A compound of the formula 45, wherein the combination of Het, R丨, R2, R3 & R4 of the compound corresponds in each case to one of the columns of Table A and R6a is as in any of Tables 24 to 2437. Tables 4066 to 4102 are compounds of the formula 46 wherein the combination of compounds Het, R1, R2, R3 & R4 corresponds in each case to one of the columns of Table A and 1163 is as in any of Tables 24 to 1437. Tables 4103 to 4139 are defined as compounds of formula 47, wherein the combination of Het, R1, R2, Rw of the compound corresponds in each case to one of the columns of Table A and R6a is as shown in Tables 24 to 1437. The compounds of the formula 140.48 defined in Table 4140 to 4176, wherein the combination of the compounds Het, R1, R2, r3 & r4 149026.doc [S] 82] 201103429 corresponds in each case to one of the tables A And R6a is as defined in any of Tables 2401 to 2437

Table A No. R1 R" RJ R4 Het A-1 Η HHH Het.l A-2 FHHH Het.l A-3 Cl HHH Het.l A-4 Br HHH Het.l A-5 ch3 HHH Het.l A- 6 chf2 HHH Het.l A-7 cf3 HHH Het.l A-8 och3 HHH Het.l A-9 ochf2 HHH Het.l A-10 OCF3 HHH Het.l A-11 HFHH Het.l A-12 H Cl HH Het.l A-13 H Br HH Het.l A-14 H ch3 HH Het.l A-15 H chf2 HH Het.l A-16 H cf3 HH Het.l A-17 H OCH3 HH Het.l A -18 H OCHF2 HH Het.l A-19 H OCF3 HH Het.l A-20 FFHH Het.l A-21 FHFH Het.l A-22 FHHF Het.l A-23 HFHF Het.l A-24 Cl HHF Het.l A-25 HHHH Het.2 A-26 FHHH Het.2 A-27 Cl HHH Het.2 A-28 Br HHH Het.2 A-29 ch3 HHH Het.2 A-30 chf2 HHH Het.2 A -31 cf3 HHH Het.2 A-32 OCH3 HHH Het.2 A-33 OCHF2 HHH Het.2 A-34 〇CF3 HHH Het.2 A-35 HFHH Het.2 A-36 H Cl HH Het.2 A- 37 H Br HH Het.2 A-38 H ch3 HH Het.2 A-39 H chf2 HH Het.2 A-40 H cf3 HH Het.2 A-41 H OCH3 HH Het.2 A-42 H OCHF2 HH Het .2 149026.doc -83- 201103429 No. R1 R3 R4 Het A-43 H OCF3 HH Het.2 A-44 FFHH Het.2 A-45 FHFH Het.2 A-46 FHHF Het.2 A-47 HFHF Het.2 A-48 Cl HHF Het.2 A-49 HHHH Het.3 A-50 FHHH Het.3 A-51 Cl HHH Het.3 A-52 Br HHH Het.3 A-53 ch3 HHH Het.3 A-54 chf2 HHH Het.3 A-55 cf3 HHH Het.3 A-56 OCH3 HHH Het .3 A-57 OCHF2 HHH Het.3 A-58 〇CF3 HHH Het.3 A-59 HFHH Het.3 A-60 H Cl HH Het.3 A-61 H Br HH Het.3 A-62 H ch3 HH Het.3 A-63 H chf2 HH Het.3 A-64 H cf3 HH Het.3 A-65 H OCH3 HH Het.3 A-66 H OCHF2 HH Het.3 A-67 H OCF3 HH Het.3 A- 68 FFHH Het.3 A-69 FHFH Het.3 A-70 FHHF Het.3 A-71 HFHF Het.3 A-72 Cl HHF Het.3 A-73 HHHH Het.4 A-74 FHHH Het.4 A- 75 Cl HHH Het.4 A-76 Br HHH Het.4 A-77 ch3 HHH Het.4 A-78 chf2 HHH Het.4 A-79 cf3 HHH Het.4 A-80 OCH3 HHH Het.4 A-81 OCHF2 HHH Het.4 A-82 OCF3 HHH Het.4 A-83 HFHH Het.4 A-84 H Cl HH Het.4 A-85 H Br HH Het.4 A-86 H ch3 HH Het.4 A-87 H Chf2 HH Het.4 A-88 H cf3 HH Het.4 A-89 H OCH3 HH He T.4 A-90 H OCHF2 H H Het.4

[SI 149026.doc -84- 201103429 No. R* RJ R4 Het A-91 H ocf3 HH Het.4 A-92 FFHH Het.4 A-93 FHFH Het.4 A-94 FHHF Het.4 A-95 HFHF Het .4 A-96 Cl HHF Het.4 A-97 HHHH Het.5 A-98 FHHH Het. 5 A-99 Cl HHH Het.5 A-100 Br HHH Het.5 A-101 ch3 HHH Het.5 A- 102 chf2 HHH Het.5 A-103 cf3 HHH Het.5 A-104 och3 HHH Het.5 A-105 ochf2 HHH Het.5 A-106 〇cf3 HHH Het.5 A-107 HFHH Het.5 A-108 H Cl HH Het.5 A-109 H Br HH Het.5 A-110 H ch3 HH Het.5 A-lll H chf2 HH Het.5 A-112 H cf3 HH Het.5 A-113 H och3 HH Het.5 A-114 H ochf2 HH Het.5 A-115 H ocf3 HH Het.5 A-116 FFHH Het.5 A-117 FHFH Het.5 A-118 FHHF Het.5 A-119 HFHF Het.5 A-120 Cl HH F. Het.5 A-121 HHHH Het.6 A-122 FHHH Het.6 A-123 Cl HHH Het.6 A-124 Br HHH Het.6 A-125 ch3 HHH Het.6 A-126 chf2 HHH Het .6 A-127 cf3 HHH Het.6 A-128 och3 HHH Het.6 A-129 ochf2 HHH Het.6 A-130 ocf3 HHH Het.6 A-131 HFHH Het.6 A-132 H Cl HH Het.6 A-133 H Br HH Het.6 A-134 H ch3 HH Het.6 A-135 H chf2 HH Het.6 A-136 H cf3 HH Het.6 A-137 H och3 HH Het.6 A-138 H ochf2 HH Het.6 149026.doc -85- 201103429 No. R1 R2 RJ R4 Het A-139 H ocf3 HH Het.6 A-140 FFHH Het.6 A-141 FHFH Het.6 A-142 FHHF Het.6 A-143 HFHF Het.6 A-144 Cl HHF Het.6 A-145 HHHH Het.7 A-146 FHHH Het.7 A-147 Cl HHH Het.7 A-148 Br HHH Het.7 A-149 ch3 HHH Het.7 A-150 chf2 HHH Het.7 A-151 cf3 HHH Het.7 A-152 och3 HHH Het.7 A-153 ochf2 HHH Het.7 A-154 ocf3 HHH Het.7 A-155 HFHH Het.7 A-156 H Cl HH Het .7 A-157 H Br HH Het.7 A-158 H ch3 HH Het.7 A-159 H chf2 HH Het.7 A-160 H cf3 HH Het.7 A-161 H och3 HH Het.7 A-162 H ochf2 HH Het.7 A-163 H ocf3 HH Het.7 A-164 FFHH Het.7 A-165 FHFH Het.7 A-166 FHHF Het.7 A-167 HFHF Het.7 A-168 Cl HHF Het. 7 A-169 HHHH Het.8 A-170 FHHH Het.8 A-171 Cl HHH Het.8 A-172 Br HHH Het.8 A-173 ch3 HHH Het.8 A-174 chf2 HHH Het.8 A-175 Cf3 H HH Het.8 A-176 och3 HHH Het.8 A-177 ochf2 HHH Het.8 A-178 ocf3 HHH Het.8 A-179 HFHH Het.8 A-180 H Cl HH Het.8 A-181 H Br HH Het.8 A-182 H ch3 HH Het.8 A-183 H chf2 HH Het.8 A-184 H cf3 HH Het.8 A-185 H och3 HH Het.8 A-186 H ochf2 HH Het.8 m 149026 .doc -86- 201103429 No. R1 R2 R3 R4 Het A-187 H ocf3 HH Het.8 A-188 FFHH Het. 8 A-189 FHFH Het.8 A-190 FHHF Het.8 A-191 HFHF Het.8 A -192 Cl HHF Het.8 A-193 HHHH Het.9 A-194 FHHH Het.9 A-195 Cl HHH Het.9 A-196 Br HHH Het.9 A-197 ch3 HHH Het.9 A-198 chf2 HHH Het.9 A-199 cf3 HHH Het.9 A-200 och3 HHH Het.9 A-201 ochf2 HHH Het.9 A-202 ocf3 HHH Het.9 A-203 HFHH Het.9 A-204 H Cl HH Het. 9 A-205 H Br HH Het.9 A-206 H ch3 HH Het.9 A-207 H chf2 HH Het.9 A-208 H cf3 HH Het.9 A-209 H och3 HH Het.9 A-210 H Ochf2 HH Het.9 A-211 H ocf3 HH Het.9 A-212 FFHH Het.9 A-213 FHFH Het.9 A-214 FHHF Het.9 A-215 HFHF Het.9 A-216 Cl HHF Het.9 A-217 H 10 A-218 FHHH Het. 10 A-219 Cl HHH Het. 10 A-220 Br HHH Het. 10 A-221 ch3 HHH Het. 10 A-222 chf2 HHH Het. 10 A-223 cf3 HHH Het. 10 A-225 ochf2 HHH Het. 10 A-226 ocf3 HHH Het. 10 A-227 HFHH Het. 10 A-228 H Cl HH Het. 10 A-229 H Br HH Het. 10 10 A-232 H cf3 HH Het. 10 A-233 H och3 HH Het. 10 A-234 H ochf2 HH Het. 10 149026.doc -87 - 201103429 No. R丨RJ R4 Het A-235 H OCF3 HH Het.10 A-236 FFHH Het. 10 A-237 FHFH Het.10 A-238 FHHF Het.10 A-239 HFHF Het.10 A-240 Cl HHF Heal.10 A-241 HHHH Het. 11 A-242 FHHH Het. 11 A-243 Cl HHH Het. 11 A-244 Br HHH Het. 11 A-245 ch3 HHH Het. 11 A-246 chf2 HHH Het. 11 A 247 AH3 HeH. Heter. H Br HH Het. 11 A-254 H ch3 HH Het. 11 A-255 H chf2 HH Het. 11 A -16 H cf3 HH Het. 11 A-257 H OCH3 HH Het. 11 A-258 H OCHF2 HH Het. 11 A-259 H OCF3 HH Het. 11 A-260 FFHH Het. 11 A-261 FHFH Het. 11 A -262 FHHF Het. 11 A-263 HFHF Het. 11 A-264 Cl HHF Het. 11 A-265 HHHH Het. 12 A-266 FHHH Het. 12 A-267 Cl HHH Het. 12 A-268 Br HHH Het. 12 A-269 ch3 HHH Het. 12 A-270 chf2 HHH Het. 12 A-271 cf3 HHH Het. 12 A-272 OCH3 HHH Het. 12 A-273 OCHF2 HHH Het. 12 A-274 OCF3 HHH Het. 12 A -275 HFHH Het. 12 A-276 H Cl HH Het. 12 A-277 H Br HH Het. 12 A-278 H ch3 HH Het. 12 A-279 H chf2 HH Het. 12 A-280 H cf3 HH Het. 12 A-281 H OCH3 HH Het. 12 A-282 H OCHF2 HH Het. 12 [s] 149026.doc -88- 201103429 No. R1 R2 RJ r Het A-283 H OCF3 HH Het.12 A-284 FFHH Het. 12 A-285 FHFH Het.12 A-286 FHHF Het.12 A-287 HFHF Het.12 A-288 Cl HHF Het.12 A-289 HHHH Het. 13 A-290 FHHH Het. 13 A-291 Cl HHH Het 13 A-292 Br HHH Het. 13 A-293 ch3 HHH Het. 13 A-294 chf2 HHH Het. 13 A-295 cf3 HHH Het. 13 A-296 OCH3 HHH Het. 13 A-297 OCHF2 HHH Het. 13 A-298 OCF3 HHH Het. 13 A-299 HFHH Het. 13 A-300 H Cl HH Het. 13 A- 301 H Br HH Het. 13 A-302 H ch3 HH Het. 13 A-303 H chf2 HH Het. 13 A-304 H cf3 HH Het. 13 A-305 H OCH3 HH Het. 13 A-306 H OCHF2 HH Het 13 A-307 H OCF3 HH Het. 13 A-308 FFHH Het. 13 A-309 FHFH Het. 13 A-310 FHHF Het. 13 A-311 HFHF Het. 13 A-312 Cl HHF Het. 13 A-313 14 A-314 FHHH Het. 14 A-315 Cl HHH Het. 14 A-316 Br HHH Het. 14 A-317 ch3 HHH Het. 14 A-318 chf2 HHH Het. 14 A-319 cf3 HHH Het. 14 A-320 OCH3 HHH Het. 14 A-321 OCHF2 HHH Het. 14 A-322 OCF3 HHH Het. 14 A-323 HFHH Het. 14 A-324 H Cl HH Het. 14 A-325 H Br HH Het.14 A-326 H ch3 HH Het. 14 A-327 H chf2 HH Het.14 A-328 H cf3 HH Het.14 A-329 H OCH3 HH Het.14 A-330 H ochf2 HH Het.14 149026.doc -89 - 201103429 No. R1 R/ R3 r Het A-331 H OCF3 HH Het.14 A-332 FFHH Het. 14 A-333 FHF H Het.14 A-334 FHHF Het.14 A-335 HFHF Het.14 A-336 Cl HHF Het.14 A-337 HHHH Het. 15 A-338 FHHH Het. 15 A-339 Cl HHH Het. 15 A- 152 Br HHH Het. 15 A-341 ch3 HHH Het. 15 A-342 chf2 HHH Het. 15 A-343 cf3 HHH Het. 15 A-344 OCH3 HHH Het. 15 A-345 OCHF2 HHH Het. 15 A-346 OCF3 15 A-347 H Cl HH Het. 15 A-349 H Br HH Het. 15 A-350 H ch3 HH Het. 15 A-351 H chf2 HH Het. 15 A-352 H cf3 HH Het. 15 A-353 H OCH3 HH Het. 15 A-354 H OCHF2 HH Het. 15 A-355 H OCF3 HH Het. 15 A-356 FFHH Het. 15 A-357 FHFH Het. 15 A-358 15 A-359 HFHF Het. 15 A-360 Cl HHF Het. 15 A-361 HHHH Het. 16 A-362 FHHH Het. 16 A-363 Cl HHH Het. 16 A-364 Br HHH Het.16 A -365 ch3 HHH Het. 16 A-366 chf2 HHH Het.16 A-367 cf3 HHH Het.16 A-368 OCH3 HHH Het.16 A-369 OCHF2 HHH Het.16 A-370 OCF3 HHH Het.16 A-371 HFHH Het.16 A-372 H Cl HH Het.16 A-373 H Br HH Het.16 A-374 H ch3 HH Het.1 6 A-375 H chf2 HH Het.16 A-376 H cf3 HH Het.16 A-377 H OCH3 HH Het.16 A-378 H OCHF2 HH Het.16 [si 149026.doc -90- 201103429 No. R1 Rj R4 Het A-379 H OCF3 HH Het.16 A-380 FFHH Het. 16 A-381 FHFH Het.16 A-382 FHHF Het.16 A-383 HFHF Het.16 A-384 Cl HHF Het.16 A-385 HHHH 17 A-386 FHHH Het. 17 A-387 Cl HHH Het. 17 A-388 Br HHH Het. 17 A-389 ch3 HHH Het. 17 A-390 chf2 HHH Het. 17 A-391 cf3 HHH Het. 17 A-392 OCH3 HHH Het. 17 A-393 OCHF2 HHH Het. 17 A-394 OCF3 HHH Het. 17 A-395 HFHH Het. 17 A-396 H Cl HH Het. 17 A-397 H Br HH Het. 17 A -398 H ch3 HH Het. 17 A-399 H chf2 HH Het. 17 A-400 H cf3 HH Het. 17 A-401 H OCH3 HH Het. 17 A-402 H OCHF2 HH Het. 17 A-403 H OCF3 HH Heter. 17 A-404 FHFH Het. 17 A-406 FHHF Het. 17 A-407 HFHF Het. 17 A-408 Cl HHF Het. 17 A-409 HHHH Het. 18 A-410 FHHH Het. 18 A-411 Cl HHH Het. 18 A-412 Br HHH Het. 18 A-413 ch3 HHH Het. 18 A-414 chf2 HHH Het. 18 A-415 cf3 HHH Het. 18 A-416 OCH3 HHH Het. 18 A-417 OCHF2 HHH Het. 18 A-418 OCF3 HHH Het. 18 A-419 HFHH Het. 18 A-420 18 A-422 H BrH HH Het. 18 A-423 H chf2 HH Het. 18 A-424 H cf3 HH Het. 18 A-425 H OCH3 HH Het. 18 A-426 H OCHF2 HH Het. 18 149026.doc -91 - 201103429 No. R1 RJ r Het A-427 H OCF3 HH Het.18 A-428 FFHH Het. 18 A-429 FHFH Het.18 A-430 FHHF Het .18 A-431 HFHF Het.18 A-432 Cl HHF Het.18 A-433 HHHH Het. 19 A-434 FHHH Het. 19 A-435 Cl HHH Het. 19 A-436 Br HHH Het. 19 A-437 19 A-438 chf2 HHH Het. 19 A-439 cf3 HHH Het. 19 A-440 OCH3 HHH Het. 19 A-441 OCHF2 HHH Het. 19 A-442 OCF3 HHH Het. 19 A-443 HFHH Het 19 A-444 H Cl HH Het. 19 A-445 H Br HH Het. 19 A-446 H ch3 HH Het. 19 A-447 H chf2 HH Het. 19 A-448 H cf3 HH Het. 19 A-449 H OCH3 HH Het. 19 A-450 H OCHF2 HH Het. 19 A-451 H OCF3 HH Het. 19 A-452 FF 19 A-453 FHFH Het. 19 A-454 FHHF Het. 19 A-455 HFHF Het. 19 A-456 Cl HHF Het. 19 A-457 HHHH Het.20 A-458 FHHH Het.20 A-459 Cl HHH Het.20 A-460 Br HHH Het.20 A-461 ch3 HHH Het.20 A-462 chf2 HHH Het.20 A-463 cf3 HHH Het.20 A-464 OCH3 HHH Het.20 A-465 OCHF2 HHH Het.20 A-466 OCF3 HHH Het.20 A-467 HFHH Het.20 A-468 H Cl HH Het.20 A-469 H Br HH Het.20 A-470 H ch3 HH Het.20 A-471 H chf2 HH Het.20 A-472 H cf3 HH Het.20 A-473 H OCH3 HH Het.20 A-474 H OCHF2 HH Het.20 m 149026.doc -92- 201103429 No. R1 R2 RJ R4 Het A-475 H OCF3 HH Het.20 A-476 FFHH Het.20 A-477 FHFH Het.20 A-478 FHHF Het.20 A-479 HFHF Het.20 A-480 Cl HHF Het.20 A-481 HHHH Het.21 A-482 FHHH Het.21 A-483 Cl HHH Het.21 A-484 Br HHH Het.21 A-485 ch3 HHH Het.21 A-486 chf2 HHH Het.21 A-487 cf3 HHH Het.21 A-488 OCH3 HHH Het .21 A-489 OCHF2 HHH Het.21 A-490 OCF3 HHH Het.21 A-491 HFHH Het.21 A-492 H Cl HH Het.21 A-493 H Br HH Het.21 A-494 H ch3 HH Het.21 A-495 H chf2 HH Het.21 A-496 H cf3 HH Het.21 A-497 H OCH3 HH Het.21 A- 498 H OCHF2 HH Het.21 A-499 H OCF3 HH Het.21 A-500 FFHH Het.21 A-501 FHFH Het.21 A-502 FHHF Het.21 A-503 HFHF Het.21 A-504 Cl HHF Het .21 A-505 HHHH Het.22 A-506 FHHH Het.22 A-507 Cl HHH Het.22 A-508 Br HHH Het.22 A-509 ch3 HHH Het.22 A-510 chf2 HHH Het.22 A- 511 cf3 HHH Het.22 A-512 OCH3 HHH Het.22 A-513 OCHF2 HHH Het.22 A-514 OCF3 HHH Het.22 A-515 HFHH Het.22 A-516 H Cl HH Het.22 A-517 H Br HH Het.22 A-518 H ch3 HH Het.22 A-519 H chf2 HH Het.22 A-520 H cf3 HH Het.22 A-521 H OCH3 HH Het.22 A-522 H OCHF2 HH Het.22 149026.doc -93- 201103429 No. R1 R2 Rj R4 Het Α-523 Η ocf3 HH Het.22 Α-524 FFHH Het.22 Α-525 F Η FH Het.22 Α-526 F Η HF Het.22 Α-527 Η FHF Het.22 Α-528 C1 Η HF Het.22 Α-529 Η Η HH Het.23 Α-530 F Η HH Het.23 Α-531 C1 Η HH Het.23 Α-532 B r Η HH Het.23 Α-533 ch3 Η HH Het.23 Α-534 chf2 Η HH Het.23 Α-535 cf3 Η HH Het.23 Α-536 OCH3 Η HH Het.23 Α-537 OCHF2 Η HH Het. 23 Α-538 OCF3 Η HH Het.23 Α-539 Η FHH Het.23 Α-540 Η C1 HH Het.23 Α-541 Η Br HH Het.23 Α-542 Η ch3 HH Het.23 Α-543 Η chf2 HH Het.23 Α-544 Η cf3 HH Het.23 Α-545 Η OCH3 HH Het.23 Α-546 Η OCHF2 HH Het.23 Α-547 Η OCF3 HH Het.23 Α-548 FFHH Het.23 Α-549 FHFH Het.23 Α-550 FHHF Het.23 Α-551 Η FHF Het.23 Α-552 C1 HHF Het.23 Α-553 Η HHH Het.24 Α-554 FHHH Het.24 Α-555 C1 HHH Het.24 Α-556 Βγ HHH Het.24 Α-557 ch3 HHH Het.24 Α-558 chf2 HHH Het.24 Α-559 cf3 HHH Het.24 Α-560 〇CH3 HHH Het.24 Α-561 OCHF2 HHH Het.24 Α -562 OCF3 HHH Het.24 Α-563 Η FHH Het.24 Α-564 Η Cl HH Het.24 Α-565 Η Br HH Het.24 Α-566 Η ch3 HH Het.24 Α-567 Η chf2 HH Het. 24 Α-568 Η cf3 HH Het.24 Α-569 Η 〇CH3 HH Het.24 Α-570 Η OCHF2 HH Het.24 [s] 149 026.doc -94· 201103429 No. R1 R2 R4 Het A-571 H OCF3 HH Het.24 A-572 FFHH Het.24 A-573 FHFH Het.24 A-574 FHHF Het.24 A-575 HFHF Het.24 A -576 Cl HHF Het.24 A-577 HHHH Het.25 A-578 FHHH Het.25 A-579 Cl HHH Het.25 A-580 Br HHH Het.25 A-581 ch3 HHH Het.25 A-582 chf2 HHH Het.25 A-583 cf3 HHH Het.25 A-584 OCH3 HHH Het.25 A-585 OCHF2 HHH Het.25 A-586 OCF3 HHH Het.25 A-587 HFHH Het.25 A-588 H Cl HH Het. 25 A-589 H Br HH Het.25 A-590 H ch3 HH Het.25 A-591 H chf2 HH Het.25 A-592 H cf3 HH Het.25 A-593 H OCH3 HH Het.25 A-594 H OCHF2 HH Het.25 A-595 H OCF3 HH Het.25 A-596 FFHH Het.25 A-597 FHFH Het.25 A-598 FHHF Het.25 A-599 HFHF Het.25 A-600 Cl HHF Het.25 A-601 HHHH Het.26 A-602 FHHH Het.26 A-603 Cl HHH Het.26 A-604 Br HHH Het.26 A-605 ch3 HHH Het.26 A-606 chf2 HHH Het.26 A-607 cf3 HHH Het.26 A-608 OCH3 HHH Het.26 A-609 OCHF2 HHH Het.26 A-610 OCF3 HHH Het.26 A-611 HFH H Het.26 A-612 H Cl HH Het.26 A-613 H Br HH Het.26 A-614 H ch3 HH Het.26 A-615 H chf2 HH Het.26 A-616 H cf3 HH Het.26 A -617 H OCH3 HH Het.26 A-618 H OCHF2 HH Het.26 149026.doc -95- 201103429 No. R丨Rz RJ R4 Het Α-619 Η OCF3 HH Het.26 Α-620 FFHH Het.26 Α-621 F Η FH Het.26 Α-622 F Η HF Het.26 Α-623 Η FHF Het.26 Α-624 C1 Η HF Het.26 Α-625 Η Η HH Het.27 Α-626 F Η HH Het.27 Α-627 C1 Η HH Het.27 Α-628 Br Η HH Het.27 Α-629 ch3 Η HH Het.27 Α-630 chf2 Η HH Het.27 Α-631 cf3 Η HH Het.27 Α-632 OCH3 Η HH Het.27 Α-633 OCHF2 Η HH Het.27 Α-634 OCF3 Η HH Het.27 Α-635 Η FHH Het.27 Α-636 Η C1 HH Het.27 Α-637 Η Βγ HH Het.27 Α- 638 Η ch3 HH Het.27 Α-639 Η chf2 HH Het.27 Α-640 Η cf3 HH Het.27 Α-641 Η OCH3 HH Het.27 Α-642 Η OCHF2 HH Het.27 Α-643 Η OCF3 HH Het .27 Α-644 FFHH Het.27 Α-645 F Η FH Het.27 Α-646 F Η HF Het.27 Α-647 Η FHF Het.27 Α-648 C1 Η HF Het.27 Α-64 9 Η Η HH Het.28 Α-650 F Η HH Het.28 Α-651 C1 Η HH Het.28 Α-652 Βγ Η HH Het.28 Α-653 ch3 Η HH Het.28 Α-654 chf2 Η HH Het .28 Α-655 cf3 Η HH Het.28 Α-656 OCH3 Η HH Het.28 Α-657 OCHF2 Η HH Het.28 Α-658 OCF3 Η HH Het.28 Α-659 Η FHH Het.28 Α-660 Η C1 HH Het.28 Α-661 Η Br HH Het.28 Α-662 Η ch3 HH Het.28 Α-663 Η chf2 HH Het.28 Α-664 Η cf3 HH Het.28 Α-665 Η OCH3 HH Het.28 Α-666 Η OCHF2 HH Het.28 [si 149026.doc ·96· 201103429 No. R1 R2 RJ r Het A-667 H OCF3 HH Het.28 A-668 FFHH Het.28 A-669 FHFH Het.28 A-670 FHHF Het.28 A-671 HFHF Het.28 A-672 Cl HHF Het.28 A-673 HHHH Het.29 A-674 FHHH Het.29 A-675 Cl HHH Het.29 A-676 Br HHH Het.29 A -677 ch3 HHH Het.29 A-678 chf2 HHH Het.29 A-679 cf3 HHH Het.29 A-680 OCH3 HHH Het.29 A-681 OCHF2 HHH Het.29 A-682 OCF3 HHH Het.29 A-683 HFHH Het.29 A-684 H Cl HH Het.29 A-685 H Br HH Het.29 A-686 H ch3 HH Het.29 A-687 H chf2 H H Het.29 A-688 H cf3 HH Het.29 A-689 H OCH3 HH Het.29 A-690 H OCHF2 HH Het.29 A-691 H OCF3 HH Het.29 A-692 FFHH Het.29 A-693 FHFH Het.29 A-694 FHHF Het.29 A-695 HFHF Het.29 A-696 Cl HHF Het.29 A-697 HHHH Het.30 A-698 FHHH Het.30 A-699 Cl HHH Het.30 A- 700 Br HHH Het.30 A-701 ch3 HHH Het.30 A-702 chf2 HHH Het.30 A-703 cf3 HHH Het.30 A-704 OCH3 HHH Het.30 A-705 OCHF2 HHH Het.30 A-706 OCF3 HHH Het.30 A-707 HFHH Het.30 A-708 H Cl HH Het.30 A-709 H Br HH Het.30 A-710 H ch3 HH Het.30 A-711 H chf2 HH Het.30 A-712 H cf3 HH Het.30 A-713 H OCH3 HH Het.30 A-714 H OCHF2 HH Het.30 149026.doc -97- 201103429 No. R1 R" RJ R4 Het A-715 H OCF3 HH Het.30 A-716 FFHH Het.30 A-717 FHFH Het.30 A-718 FHHF Het.30 A-719 HFHF Het.30 A-720 Cl HHF Het.30 A-721 HHHH Het.31 A-722 FHHH Het.31 A-723 Cl HHH Het.31 A-724 Br HHH Het.31 A-725 ch3 HHH Het.31 A-726 chf2 HHH Het.31 A-727 cf3 HHH He T.31 A-728 OCH3 HHH Het.31 A-729 OCHF2 HHH Het.31 A-730 OCF3 HHH Het.31 A-731 HFHH Het.31 A-732 H Cl HH Het.31 A-733 H Br HH Het .31 A-734 H ch3 HH Het.31 A-735 H chf2 HH Het.31 A-736 H cf3 HH Het.31 A-737 H OCH3 HH Het.31 A-738 H OCHF2 HH Het.31 A-739 H OCF3 HH Het.31 A-740 FFHH Het.31 A-741 FHFH Het.31 A-742 FHHF Het.31 A-743 HFHF Het.31 A-744 Cl HHF Het.31 A-745 HHHH Het.32 A -746 FHHH Het.32 A-747 Cl HHH Het.32 A-748 Br HHH Het.32 A-749 ch3 HHH Het.32 A-750 chf2 HHH Het.32 A-751 cf3 HHH Het.32 A-752 OCH3 HHH Het.32 A-753 OCHFz HHH Het.32 A-754 OCF3 HHH Het.32 A-755 HFHH Het.32 A-756 H Cl HH Het.32 A-757 H Br HH Het.32 A-758 H ch3 HH Het.32 A-759 H chf2 HH Het.32 A-760 H cf3 HH Het.32 A-761 H OCH3 HH Het.32 A-762 H OCHF2 HH Het.32 [si 149026.doc •98- 201103429 RJ R" RJ R4 Het A-763 H OCF3 HH Het.32 A-764 FFHH Het.32 A-765 FHFH Het.32 A-766 FHHF Het.32 A-767 H FHF Het.32 A-768 Cl HHF Het.32 A-769 HHHH Het.33 A-770 FHHH Het.33 A-771 Cl HHH Het.33 A-772 Br HHH Het.33 A-773 ch3 HHH Het.33 A-774 chf2 HHH Het.33 A-775 cf3 HHH Het.33 A-776 OCH3 HHH Het.33 A-777 OCHF2 HHH Het.33 A-778 OCF3 HHH Het.33 A-779 HFHH Het.33 A-780 H Cl HH Het.33 A-781 H Br HH Het.33 A-782 H ch3 HH Het.33 A-783 H chf2 HH Het.33 A-784 H cf3 HH Het.33 A-785 H OCH3 HH Het. 33 A-786 H OCHF2 HH Het.33 A-787 H OCF3 HH Het.33 A-788 FFHH Het.33 A-789 FHFH Het.33 A-790 FHHF Het.33 A-791 HFHF Het.33 A-792 Cl HHF Het.33 A-793 HHHH Het.34 A-794 FHHH Het.34 A-795 Cl HHH Het.34 A-796 Br HHH Het.34 A-797 ch3 HHH Het.34 A-798 chf2 HHH Het. 34 A-799 cf3 HHH Het.34 A-800 OCH3 HHH Het.34 A-801 OCHF2 HHH Het.34 A-802 OCF3 HHH Het.34 A-803 HFHH Het.34 A-804 H Cl HH Het.34 A -805 H Br HH Het.34 A-806 H ch3 HH Het.34 A-807 H chf2 HH Het.34 A-808 H cf3 HH Het.34 A-809 H och3 HH Het.34 A-810 H OCHF2 HH Het.34 149026.doc -99- 201103429 No. R1 Rz RJ r Het A-811 H OCF3 HH Het.34 A-812 FFHH Het.34 A-813 FHFH Het.34 A- 814 FHHF Het.34 A-815 HFHF Het.34 A-816 Cl HHF Het.34 A-817 HHHH Het.35 A-818 FHHH Het.35 A-819 Cl HHH Het.35 A-820 Br HHH Het.35 , A-821 ch3 HHH Het.35 A-822 chf2 HHH Het.35 A-823 cf3 HHH Het.35 A-824 OCH3 HHH Het.35 A-825 OCHF2 HHH Het.35 A-826 OCF3 HHH Het.35 A -827 HFHH Het.35 A-828 H Cl HH Het.35 A-829 H Br HH Het.35 A-830 H ch3 HH Het.35 A-831 H chf2 HH Het.35 A-832 H cf3 HH Het. 35 A-833 H OCH3 HH Het.35 A-834 H OCHF2 HH Het.35 A-835 H OCF3 HH Het.35 A-836 FFHH Het.35 A-837 FHFH Het.35 A-838 FHHF Het.35 A -839 HFHF Het.35 A-840 Cl HHF Het.35 A-841 HHHH Het.36 A-842 FHHH Het.36 A-843 Cl HHH Het.36 A-844 Br HHH Het.36 A-845 ch3 HHH Het .36 A-846 chf2 HHH Het.36 A-847 cf3 HHH Het.36 A-848 OCH3 HHH Het.36 A-849 OCHF2 HHH Het.36 A-850 OCF3 HHH Het.36 A-851 HFHH Het.36 A-852 H Cl HH Het.36 A-853 H Br HH Het.36 A-854 H ch3 HH Het.36 A-855 H chf2 HH Het. 36 A-856 H cf3 HH Het.36 A-857 H OCH3 HH Het.36 A-858 H OCHF2 HH Het.36

[SI 149026.doc -100- 201103429 No. RJ R2 r Het A-859 H OCF3 HH Het.36 A-860 FFHH Het.36 A-861 FHFH Het.36 A-862 FHHF Het.36 A-863 HFHF Het. 36 A-864 Cl HHF Het.36 A-865 HHHH Het.37 A-866 FHHH Het.37 A-867 Cl HHH Het.37 A-868 Br HHH Het.37 A-869 ch3 HHH Het.37 A-870 Chf2 HHH Het.37 A-871 cf3 HHH Het.37 A-872 och3 HHH Het.37 A-873 OCHF2 HHH Het.37 A-874 OCF3 HHH Het.37 A-875 HFHH Het.37 A-876 H Cl HH Het.37 A-877 H Br HH Het.37 A-878 H ch3 HH Het.37 A-879 H chf2 HH Het.37 A-880 H cf3 HH Het.37 A-881 H OCH3 HH Het.37 A- 882 H OCHF2 HH Het.37 A-883 H OCF3 HH Het.37 A-884 FFHH Het.37 A-885 FHFH Het.37 A-886 FHHF Het.37 A-887 HFHF Het.37 A-888 Cl HHF Het .37 A-889 HHHH Het.38 A-890 FHHH Het.38 A-891 Cl HHH Het.38 A-892 Br HHH Het.38 A-893 ch3 HHH Het.38 A-894 chf2 HHH Het.38 A- 895 cf3 HHH Het.38 A-896 OCH3 HHH Het.38 A-897 OCHF2 HHH Het.38 A-898 OCF3 HHH Het.38 A-899 HFHH Het.38 A-900 H Cl HH Het.38 A-901 H Br HH Het.38 A-902 H ch3 HH Het.38 A-903 H chf2 HH Het.38 A-904 H cf3 HH Het.38 A -905 H 〇CH3 HH Het.38 A-906 H ochf2 HH Het.38 149026.doc -101 - 201103429 No. R1 Rz RJ R4 Het A-907 H OCF3 HH Het.38 A-908 FFHH Het.38 A-909 FHFH Het.38 A-910 FHHF Het.38 A-911 HFHF Het.38 A-912 Cl HHF Het.38 A-913 HHHH Het.39 A-914 FHHH Het.39 A-915 Cl HHH Het.39 A- 916 Br HHH Het.39 A-917 ch3 HHH Het.39 A-918 chf2 HHH Het.39 A-919 cf3 HHH Het.39 A-920 OCH3 HHH Het.39 A-921 OCHF2 HHH Het.39 A-922 OCF3 HHH Het.39 A-923 HFHH Het.39 A-924 H Cl HH Het.39 A-925 H Br HH Het.39 A-926 H ch3 HH Het.39 A-927 H chf2 HH Het.39 A-928 H cf3 HH Het.39 A-929 H OCH3 HH Het.39 A-930 H OCHF2 HH Het.39 A-931 H OCF3 HH Het.39 A-932 FFHH Het.39 A-933 FHFH Het.39 A-934 FHHF Het.39 A-935 HFHF Het.39 A-936 Cl HHF Het.39 A-937 HHHH Het.40 A-938 FHHH Het.40 A-939 Cl HHH Het.40 A-940 Br HHH Het.40 A-941 ch3 HHH Het.40 A-942 chf2 HHH Het.40 A-943 cf3 HHH Het.40 A-944 OCH3 HHH Het.40 A-945 OCHF2 HHH Het. 40 A-946 OCF3 HHH Het.40 A-947 HFHH Het.40 A-948 H Cl HH Het.40 A-949 H Br HH Het.40 A-950 H ch3 HH Het.40 A-951 H chf2 HH Het .40 A-952 H cf3 HH Het.40 A-953 H OCH3 HH Het.40 A-954 H OCHF2 HH Het.40 [si 149026.doc -102- 201103429 No. R1 R2 Rj R4 Het A-955 H ocf3 HH Het.40 A-956 FFHH Het.40 A-957 FHFH Het.40 A-958 FHHF Het.40 A-959 HFHF Het.40 A-960 Cl HHF Het.40 A-961 HHHH Het.41 A-962 FHHH Het.41 A-963 Cl HHH Het.41 A-964 Br HHH Het.41 A-965 CH3 HHH Het.41 A-966 chf2 HHH Het.41 A-967 cf3 HHH Het.41 A-968 och3 HHH Het. A-969 ochf2 HHH Het. 41 A-975 H chf2 HH Het.41 A-976 H cf3 HH Het.41 A-977 H och3 HH Het.41 A-978 H ochf2 HH Het.41 A-979 H ocf3 HH Het.41 A-980 FFHH Het.41 A-981 FHFH Het.41 A-982 FHHF Het.41 A-983 HFHF Het.41 A-984 Cl HHF Het.41 A-985 HHHH Het.42 A -986 FHHH Het.42 A-987 Cl HHH Het.42 A-988 Br HHH Het.42 A-989 ch3 HHH Het.42 A-990 chf2 HHH Het.42 A-991 cf3 HHH Het.42 A-992 och3 HHH Het.42 A-993 ochf2 HHH Het.42 A-994 ocf3 HHH Het.42 A-995 HFHH Het.42 A-996 H Cl HH Het.42 A-997 H Br HH Het.42 A-998 H ch3 HH Het.42 A-999 H chf2 HH Het.42 A-1000 H cf3 HH Het.42 A-1001 H och3 H . H Het.42 A-1002 H ochf2 HH Het.42 149026.doc -103- 201103429 R1 RJ r Het A-1003 H ocf3 HH Het.42 A-1004 FFHH Het.42 A-1005 FHFH Het.42 A-1006 FHHF Het.42 A-1007 HFHF Het.42 A-1008 Cl HHF Het.42 A -1009 HHHH Het.43 A-1010 FHHH Het.43 A-1011 Cl HHH Het.43 A-1012 Br HHH Het.43 A-1013 ch3 HHH Het.43 A-1014 chf2 HHH Het.43 A-1015 cf3 HHH Het.43 A-1016 och3 HHH Het.43 A-1017 ochf2 HHH Het.43 A-1018 ocf3 HHH Het. 43 A-1019 HFHH Het.43 A-1020 H Cl HH Het.43 A-1021 H Br HH Het.43 A-1022 H ch3 HH Het.43 A-1023 H chf2 HH Het.43 A-1024 H cf3 HH Het.43 A-1025 H och3 HH Het.43 A-1026 H ochf2 HH Het.43 A-1027 H ocf3 HH Het.43 A-1028 FFHH Het.43 A-1029 FHFH Het.43 A-1030 FHHF Het. 43 A-1031 HFHF Het.43 A-1032 Cl HHF Het.43 A-1033 HHHH Het.44 A-1034 FHHH Het.44 A-1035 Cl HHH Het.44 A-1036 Br HHH Het.44 A-1037 ch3 HHH Het.44 A-1038 chf2 HHH Het.44 A-1039 cf3 HHH Het.44 A-1040 och3 HHH Het.44 A-1041 ochf2 HHH Het.44 A-1042 ocf3 HHH Het.44 A-1043 HFHH Het. 44 A-1044 H Cl HH Het.44 A-1045 H Br HH Het.44 A-1046 H ch3 HH Het.44 A-1047 H chf2 HH Het.44 A-1048 H cf3 HH Het.44 A-1049 H Och3 HH Het.44 A-1050 H ochf2 HH Het.44 [s] 149026.doc •104- 201103429 No. R1 R2 RJ r Het A-1051 H ocf3 HH Het.44 A-1052 FFHH Het.44 A-1053 FHFH Het.44 A-1054 FHHF Het.44 A-1055 HFHF Het.44 A-1056 Cl HHF Het.44 A-1057 H HHH Het.45 A-1058 FHHH Het.45 A-1059 Cl HHH Het.45 A-1060 Br HHH Het.45 A-1061 ch3 HHH Het.45 A-1062 chf2 HHH Het.45 A-1063 cf3 HHH Het. 45 A-1064 och3 HHH Het.45 A-1065 ochf2 HHH Het.45 A-1066 ocf3 HHH Het.45 A-1067 HFHH Het.45 A-1068 H Cl HH Het.45 A-1069 H Br HH Het.45 A-1070 H ch3 HH Het.45 A-1071 H chf2 HH Het.45 A-1072 H cf3 HH Het.45 A-1073 H och3 HH Het.45 A-1074 H ochf2 HH Het.45 A-1075 H OCF3 HH Het.45 A-1076 FFHH Het.45 A-1077 FHFH Het.45 A-1078 FHHF Het.45 A-1079 HFHF Het.45 A-1080 Cl HHF Het.45 A-1081 HHHH Het.46 A-1082 FHHH Het.46 A-1083 Cl HHH Het.46 A-1084 Br HHH Het.46 A-1085 ch3 HHH Het.46 A-1086 chf2 HHH Het.46 A-1087 cf3 HHH Het.46 A-1088 och3 HHH Het .46 A-1089 ochf2 HHH Het.46 A-1090 ocf3 HHH Het.46 A-1091 HFHH Het.46 A-1092 H Cl HH Het.46 A-1093 H Br HH Het.46 A-1094 H ch3 HH Het .46 A-1095 H chf2 HH Het.46 A-1096 H cf3 HH Het.46 A-1097 H OCH3 HH Het .46 A-1098 H OCHF2 HH Het.46 149026.doc -105- 201103429 No. R1 RJ R4 Het A-1099 H ocf3 HH Het.46 A-1100 FFHH Het.46 A-1101 FHFH Het.46 A-1102 FHHF Het.46 A-1103 HFHF Het.46 A-1104 Cl HHF Het.46 A-1105 HHHH Het.47 A-1106 FHHH Het.47 A-1107 Cl HHH Het.47 A-1108 Br HHH Het.47 A- 1109 ch3 HHH Het.47 A-1110 chf2 HHH Het.47 A-llll cf3 HHH Het.47 A-1112 och3 HHH Het.47 A-1113 ochf2 HHH Het.47 A-1114 ocf3 HHH Het.47 A-1115 HFHH Het.47 A-1116 H Cl HH Het.47 A-1117 H Br HH Het.47 A-1118 H ch3 HH Het.47 A-1119 H chf2 HH Het.47 A-1120 H cf3 HH Het.47 A- 1121 H och3 HH Het.47 A-1122 H ochf2 HH Het.47 A-1123 H ocf3 HH Het.47 A-1124 FFHH Het.47 A-1125 FHFH Het.47 A-1126 FHHF Het.47 A-1127 HFHF Het.47 A-1128 Cl HHF Het.47 A-1129 HHHH Het.48 A-1130 FHHH Het.48 A-1131 Cl HHH Het.48 A-1132 Br HHH Het.48 A-1133 ch3 HHH Het.48 A -1134 chf2 HHH Het.48 A-1135 cf3 HHH Het.48 A-1136 och3 HHH Het.48 A-1137 ochf2 HHH Het.48 A-1138 ocf3 HHH Het.48 A-1139 HFHH Het.48 A-1140 H Cl HH Het.48 A-1141 H Br HH Het.48 A-1142 H ch3 HH Het.48 A-1143 H chf2 HH Het.48 A-1144 H cf3 HH Het.48 A-1145 H och3 HH Het.48 A-1146 H ochf2 HH Het.48 [si 149026.doc •106- 201103429

The groups Het·1 to Het.49 correspond to the groups of the specific examples of Het listed above as the group of the formulas Het" to Het 49. Among the above compounds, preferred are compounds of the formulae L1 to 124, and to II.24. Among these compounds, preferred are compounds u, 1.2 ^ 1.13 ^ 1.14 > 1.49 ^ 1.50, 1.61 ^ 1.62 ^ IU, II 2 , II 13 and Π. More preferably, the compounds U, 1.2, 1.49, f.5, η, and JI2 and even more preferably are compounds and „·2β compounds of the formulae I and II can be listed by the following schemes 1 to 9 And 149026.doc.107-201103429 The methods and variations described in the synthesis details are prepared. The variables are as defined above for Formulas I and π. Compounds of Formula 1, wherein r6 is oxime and m is 0 (or Compound II, Wherein R6a is H), the vulcanization reaction can be carried out by vulcanization of the corresponding triazole derivative a as outlined in Flow 1, which can be carried out analogously (e.g., as described in WO 96/41 804). For example, a triazolyl ring may first be deprotonated with a strong base such as an organolithium base such as n-butyllithium, tert-butyllithium

Potassium tert-butoxide mixed with ethylenediamine (TMEDA), and the resulting anion is then reacted with alizarin sulfur. General use of powdered sulfur. The reaction is generally carried out in an inert solvent, methyl tert-butyl hydrazine, tetrahydrofuran or two-liquid ammonia, dimethyl sulfoxide or decyl decylamine such as hydrazine (for example, diethyl sulfonate, methyl phthalocyanine). , dimethoxyethane, liquid ammonia, medium. The reaction temperature is not critical and can be, for example, from _7 〇 to +5 〇. 〇, preferably within the range of -70 to 〇 °C. Alternatively, the sulfurization reaction may be heated to, for example, by reacting 7 with elemental sulfur in a high boiling solvent such as N-methylpyrrolidine dimethylamine, in the absence of a test. After the reaction, the reaction is carried out, for example, by adding water ketone, dioxane or N, N-di 160 to 250 °C. Or aqueous acid, such as a mineral acid such as dilute sulfuric acid or hydrochloric acid or acetic acid to hydrolyze the resulting mixture to give compound I. Scheme 1

149026.doc -108- 201103429 As outlined in Scheme 2, the triazole compound IV can be prepared analogously to known methods, such as described, for example, in EP-A-0 065 485. For example, a compound; 1 (wherein X is a good leaving group, such as a ruthenium atom, especially oxime, ^ or I'phenylsulfonyloxy, p-toluenesulfonyloxy, trifluoroacetoxy Or a mercapto group, such as a fluorenyloxy group, can be reacted with an oxadiazole compound 2 (wherein hydrazine is a hydrogen atom or a metal atom, especially an alkali metal atom such as Li, Na or hydrazine) In the case of 11, the reaction is preferably carried out in a base such as an alkali metal hydride (e.g., sodium hydride, potassium hydride), an alkali metal hydroxide (e.g., sodium hydroxide, potassium hydroxide), an alkali metal carbonate (e.g., sodium carbonate, carbonic acid). It is carried out in the presence of potassium, carbonic acid or a suitable amine such as triethylamine, triethylenediamine, piperidine, pyridine, 4-dimethylaminopyridine or 4-pyrrolidinylpyridine. If X is C1 or Br, the reaction can be promoted by the addition of an alkali metal iodide such as Nal or KI. The reaction is preferably carried out in a solvent. Suitable solvents are inert solvents and the reactants are quite polar to the product, for example, N,N-dimethyl decylamine, N,N-dimercaptoacetamide, diterpene, acetonitrile, carbonitrile, A mystery (such as di-butyl scale, diacetyl, methyl ri-butyl ether, tetrahydrofuran or dioxane) and its analogs, and can be used in combination with other less polar inert solvents such as benzene'toluene, Diphenylbenzene, gas benzene, nitrobenzene, hexane, heptane, petroleum ether and the like. The reaction temperature is not critical and can be, for example, from 0 to 220. Preferably, it is in the range of 80 to 170 °C. The reaction is preferably carried out at the reflux temperature of the reaction mixture. 149026.doc •109- 201103429 Process 2

Compound J can, in turn, be prepared analogously to known methods, such as those described in EP-A-0 065 485 or Synthesis, 1974, I, 23, as outlined in Scheme 3 below. For example, ketone 3 may be a compound which forms an azeotrope with diol H〇_A_〇t^i (such as benzene, toluene, diphenylbenzene, gas, or tetra-methane, which may also act as a reaction). The reaction is carried out for several hours in the presence of a solvent. The ketalization reaction is promoted by the presence of a strong acid such as p-toluene. Subsequent halogenation of the resulting ketal 4 produces a ketal 1, which in turn is a zeolitic atom which, if desired, can be converted to compound j, wherein oxime is a cleavage group other than halogen. Process 3

As outlined in Scheme 4 below, ketone 3 can be similar to known methods (such as, for example, the condensation reaction of compounds 5 and 6 as described in ΕΡ-Α-0065485), where X1 is a group γ_Η or Υ- Μ, wherein Μ is a metal atom, especially an alkali metal atom such as Li, Na or ruthenium, and X 2 is a good leaving group such as a halogen atom such as F, Cl, Br or I'phenyl acyloxy, A 149026.doc • 110-201103429 Benzenesulfonyloxy, trifluoroacetoxy or alkylsulfonyloxy, such as methylsulfonyloxy' or vice versa, where X1 is a good leaving group And χ2 is a group YH or YM. In the case where X1 or X2 is YH, the reaction is preferably tested, such as alkali metal hydride (such as sodium hydride, potassium hydride), metal hydroxide (such as sodium aroxide, potassium hydroxide), alkali metal carbonate ( For example, sodium carbonate, potassium carbonate, carbonic acid or a suitable amine (for example, triethylamine, triethylenediamine, piperidine, pyridine, 4-dimethylaminopyridine, 4-pyrrolidinopyridine) . If the leaving group X1 or X2 is C1 or Br, the reaction can be promoted by adding an alkali metal hardened substance such as NaI or KI. The reaction is preferably carried out in a solvent. Suitable solvents are inert solvents and the reactants are quite polar to the product, for example, hydrazine, hydrazine-dimercaptoamine, hydrazine, hydrazine dimethyl acetamide, bismuth acetonitrile, acetonitrile, carbonitrile, Ethers (such as diethyl hydrazine, dipropylene, methyl second butyl ether, tetrahydrofuran or dioxane) and the like, and can be used in combination with other less polar inert solvents, such as benzene, hydrazine Diphenylbenzene, chlorobenzene, nitrobenzene, hexane, heptane, petroleum ether and the like. The reaction temperature is not critical and can range, for example, to 22 Torr. And preferably 8 to 17 inches. Within the scope of 〇. The reaction is preferably carried out at the reflux temperature of the reaction mixture. Process 4

As an alternative to the method described in Scheme 4, as outlined in Scheme 5 below, Scheme 3 (where 丫 is 0 (= 3,)) can be similar to the method of 149026.doc 201103429 in εΡ-α_〇〇65485 It is prepared by the decarboxylation reaction of carbonate 7. It can also be prepared from hydroxy compound 8: hydroxy compound 8 is reacted with a difunctional derivative 9 of the following carbonic acid, such as phosgene, halogen bismuth diacetate, dimercaptocarbonate or S, or diphenyl carbonate. And further react with the 10. The decarboxylation reaction is carried out by heating in an inert solvent such as diphenyl ether or ethylene glycol dioxime in the range of from 7 to 120 to 220 °C. Process 5

+ recognition

As an alternative to the method described in Scheme 2, compound IV can be prepared by a ketalization reaction of ketone 11 with diol HO-A-OH, similar to the method described in Ep_A_0065485, as outlined in Scheme 6 below. The ketalization reaction can be carried out under the reaction conditions described in Scheme 3. Process 6

149026.doc • The method described in 112-201103429 'by compound 12 (wherein X is a good leaving group, such as a halogen atom, especially C1, hydrazine or phenylsulfonyloxy, p-toluenesulfonate) The decyloxy, trifluoroacetoxy or alkylsulfonyloxy group, such as methylsulfonyloxy, is prepared by reacting the triazole compound 2 under the reaction conditions described for the reaction in Scheme 2. Compound 12 is in turn obtainable from the halogenation of ketone 3. Process 7

As an alternative to the process described in Scheme 2, compound IV can be prepared analogously to the process described in EP_A_0065485 by condensing compounds 13 and 14 under the reaction conditions described in Scheme 4, as outlined in Scheme 8 below. Wherein X1 is a group YH or YM, wherein hydrazine is a metal atom, especially an alkali metal atom such as Li, Na or hydrazine, and X2 is a good cleavage group, such as a _ atomic atom 'particularly Cl, Br or I, a stupid group Continuing the oxy-oxyl group, the fluorene-based phenolic aldehyde, the aldehyde or the decyloxy group, such as a fluorenyloxy group, and vice versa, wherein X1 is a good leaving group and X2 is a group γ_Η or γ·Μ. Process 8

149026.doc -113 - 201103429 As an alternative to the method described in Scheme 2, compound iv (where γ is 0 (= IV,)) can be similar to the method described in eP_a_0065485, as outlined in Scheme 9 below. Prepared by decarboxylation of carbonate 15 under the reaction conditions described in Scheme 5. Carbonate 15 can in turn be prepared under the reaction conditions described for the condensation reaction in Scheme 5. Process 9

Compounds 5, 6, 8, 9 and 1 which are commercially available for use in the above reactions may be made by standard methods known to those skilled in the art. If the groups R, R2, R3, R4 and R5 in the above reactants are inert to the respective reactions, they may be present in the above reaction step or may be introduced in, for example, the compound IV in the latter stage. A compound of formula 1 wherein R6 is not hydrogen and can be prepared from compound 1 (R6=H and m=〇 in 1). Formula (where m is 〇 and r6 is cr κ. « Its r Γ and R is "3丨-Ci〇alkyl, haloalkyl 2-Cl° dilute, Cc“alkenyl, c2-Cl. Block, c2_c “alkynyl, C3-C丨. Ring-based, c, base ... 3 10 tooth (tetra), phenyl, phenyl like 4 alkyl, the last two of which are mentioned in the group /JU s person J can be replaced as described above, 3 has 1, 2 or 3 The 5- or 6-membered saturated or adjacent gossip of the heterogenes selected from N, 0 and 8 is an unsaturated or aristocratic heterocyclic ring, wherein the heterocyclic ring can be as [si 149026.doc -114- 201103429 The above substituted) can be similar to the method described in DE-A-19520098 or WO 96/41804 by combining (wherein 111 is 〇 and 116 is imprinted with compound R6-LG (wherein R6 has the above meaning) One of the compounds is prepared by reacting a group such as a halogen group (e.g., Cl, Br, I), a sulfonate group or an oxime sulfonate group. Suitable bases are, for example, alkali metal hydrides. (such as sodium hydride, potassium hydride), alkali metal hydroxide (such as hydrogen and oxygen) Sodium, potassium hydroxide), alkali metal carbonates (such as sodium carbonate, potassium carbonate, carbonic acid planing), alkali metal alkoxides (such as sodium methoxide, potassium methoxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or organic Lithium bases (for example, n-butyllithium, t-butyllithium, t-butyllithium, and lithium diisopropylamine are generally reacted in a suitable solvent. Suitable solvents are, for example, toluene, N-methylpyrrolidone, Ethers (eg, diethyl bond, tetrahydroanion, dialdehyde, 12. dimethoxyethane), acetonitrile 'n, n-didecylguanamine or dimethyl sulfoxide. Alternatively, a compound of formula I (where „1 is 0 and the uldent 6 is Ci_Ci〇alkyl, Ci_c-alkyl, c2-ClGalkenyl' C2_CiG halo, C2_Ci❶ block, c2_c i alkynyl, 匚3-(:10 cycloalkyl, C3_Ci 〇 环 、 、, phenyl, phenyl _c c4 alkyl' 苯基 The phenyl moiety in the last two mentioned groups may be substituted as described above, and contains 2 or 3 selected from Ν, 〇 And a hetero atom of 8 as a ring member, a 5 or 6 member saturated, partially unsaturated or aromatic heterocyclic ring wherein the heterocyclic ring may be substituted as described above) may be similar to Heter〇cycles 23(7), 1645_ secret, the method described in 1985, by reacting a compound with a disulfide R6_s_m in the presence of a compound similar to that described in Scheme! (where is a C (=〇) R,c(=s)Ri2) can be classified as 149026.doc -115-201103429. The method described in DE-A-19617461, by compounding ^ (where the claw is 0 and R6 is Η) and the compound ri2_c (=〇)_w, r12_c(=s)_w, Rn,_N=00 or Ri2'_N=c = s (where Rl2 has one of the above meanings, (VC,. An alkyl group or a Ci_ClGM group and is a good leaving group such as a dentate group (e.g., Cl Br, I), an alkoxy group (e.g., a decyloxy group, an ethoxyoxy group) or a pentafluorophenoxy group. The reaction is prepared. Suitable tests are, for example, hydrides (such as sodium hydride, potassium hydride), metal hydroxides (such as sodium hydroxide, potassium hydroxide), alkali metal carbonates such as sodium carbonate, potassium carbonate, and carbonic acid. a metal alkoxide (such as sodium methoxide, methanol _, sodium ethoxide, potassium ethoxide, potassium butoxide) or an organic lithium base (such as n-butyl lithium, second butyl, tert-butyl, and Isopropylamine clock. The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, toluene, n-methyl sulfonate, and ethers (eg diethyl ether, tetrahydrofuran, dioxane, i, 2-di) Methoxyethane), [nitrile, N,N-didecylguanamine or disulfoxide. The compound of formula 1 (whose towel 1 is 0 and R6 is -so2r12) can be similar to that described in DE_a. By way of example, compound 1 (where m is 0 and R6 is H) and compound R's〇2_w (wherein Rl2 has one of the above meanings and w is a good leaving group, such as a dentate group (eg, a, An oxy group (for example, anthraceneoxy 6 alkoxy) or pentafluorophenoxy) is prepared by reacting in the presence of a test. Metal hydrides (such as sodium hydride, cesium hydride, alkali metal hydroxides (such as sodium hydroxide, chlorinated oxime), metal carbonates (such as sodium carbonate, carbonic acid, barium carbonate), alkali metal alkoxides (such as methanol) Sodium, potassium steroxide, sodium ethoxide, potassium ethoxide, potassium butoxide) or organic lithium base (eg n-butyl lithium, second butyl lithium, tert-butyl lithium, diisopropyl 149026.doc -116- 201103429 Lithium amine). The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, hydrazine, hydrazine-methylpyrrolidine, ethers (e.g., diethyl ether, tetrahydrofuran, dioxane, 1,2-dioxene). Ethyl ethane), acetonitrile, hydrazine, hydrazine-dimercaptocaramine or diterpene. The compound of formula I (wherein m is hydrazine and R6 is -CN) can be similar to the method described in De_a 19620407, It is prepared by reacting a compound (in which 〇 and ... is H) with a compound CN-W (where | is a good leaving group such as a halogen group (e.g., Cl, Br, I)) in the presence of a base. For example, an alkali disk hydride (such as sodium hydride, hydrogenation clock), an alkali metal hydroxide (such as sodium hydroxide, Potassium oxide), alkali metal carbonates (such as sodium carbonate, potassium carbonate, cesium carbonate), alkali metal alkoxides (such as sodium methoxide, potassium decoxide, potassium ethoxide, second butanol) or organic tests (such as positive Butyl | butyl, lithium butyl lithium, lithium butyl hydride, lithium diisopropyl amide. The reaction is generally carried out in a suitable solvent. Suitable solvents are, for example, toluene, N-methylpyrrolidone, ethers. (e.g., diethyl ether, tetrahydrofuran, dioxane, hydrazine, 2-dimethoxy ethane), acetonitrile, N,N-dimercaptocaramine or dimethyl sulfoxide. 1 is 0 and the rule 6 is a dish) can be similar to the method described in 1) £_8-196^82 by making compound 1 (where m is 0 and R6 is H) and amine NR RR (where Ra, Rb&RC is as defined above) or prepared by reaction with a metal salt such as sodium hydroxide, potassium hydroxide or copper acetate. A compound of formula I (wherein „! is 〇 and R 6 is a group of formula m) can be similar to the method described in w〇97/43269 by combining (where m is 〇 and R6 is H) with halogen (especially Iodine) is prepared by reacting in the presence of a base. Suitable bases are, for example, alkali metal hydrides (e.g., sodium hydride, potassium hydride), metal hydroxides I49026.doc 117 201103429 (e.g., sodium bismuth oxide, sodium hydroxide, carbonic acid) Potassium, carbonic acid) alkali metal carbonate (such as carbonic acid clock, B), metal alkoxide (such as methanol sodium 'potassium methoxide, sodium ethoxide, potassium ethoxide, third r ^ - -r ^ ^ - potassium butoxide) Or an organic lithium base (such as lithium n-butylate, n-butyl lithium, such as yttrium, butyl ketone, lithium diisopropylamine). The reaction is pushed in a solvent of δ. * 仃.5 Suitable solvents are, for example, toluene, hydrazine-methylpyrrolidone, ethers (for example, dipo-indenyl m Μ ^ tetrahydrofuran, dioxane, 1,2-dimethoxyethane), acetonitrile, hydrazine _ , T . , . , --Methylformamide or dimethyl sulfoxide. Formula 1 & (where m is 6 only 6^_ is '

QQ/OS14Q cfa ό is -P(=Q)Rl3R14) can be prepared similarly to the method described in WO 99/〇5149. A hydrazone compound (wherein R 6a A is 6 in hydrazine) can be prepared by a compound similar to the compound I (in the s conversion reaction of Ji, the cis " group (where h) is reacted with (4) R is not ruthenium. The claw is 丨 or -) prepared by oxidation reaction from each compound 1 (where m is 0). Red ginseng, .u second 'Compound 1 (where 〇 is 2) can be made by first making a trimethyl fluorene ring After removing 皙$#, 豉'豉 and reacting with sulfonium gas R6S02C1. Compound IV is prepared. Compound! (where the claw is 3) can be first protonated by removing the salicin from the salicinium. Or a sulphuric acid vinegar vaporized product (wherein R6 is selected from the group consisting of f, hydrazine H, C 丨-Cw, sulphate, C-uu-alkyl, C2-Ci fluorenyl, C2-C "dilute, C2_Ci decynyl, C2_c"alkynyl, C3-Cl^alkyl, C3'ClQ-dental alkyl, phenyl, phenyl-Cl-C4 alkyl, wherein the phenyl moiety in the last two mentioned groups can be as described above Substituted and a having 2 or 3 of a 5 or 6 membered saturated, partially unsaturated or aromatic heterocyclic ring selected from the heteroatoms of N, 〇as, wherein the heterocyclic ring may be substituted as described above) Prepared by IV. [S] 1 49026.doc -118- 201103429 If individual compounds cannot be prepared by the above route, they can be prepared by derivatization of other compounds I and II or by conventional modification of the synthetic route. The reaction mixture is treated in a conventional manner. For example, by mixing with water, separating the phases and, if appropriate, purifying the crude product by chromatography, for example, on alumina or tannin, some intermediates and final products in the form of colorless or light brown viscous oils are obtained. It does not contain volatile components or is purified under reduced pressure and moderately high temperature without volatile components. If intermediates and final products are obtained in solid form, they can be purified by recrystallization or decomposition. Another aspect is related to the compound of formula IV:

Wherein Het, A, Y, R1, r2, r3 & r4 have one of the general or particularly preferred meanings given above for compound II. Compound IV - aspects are useful intermediates in the preparation of compounds I and II (see the above scheme), and on the other hand have significant fungicidal activity. Particularly preferred compound 1V is a compound of the formulae IV.1 to IV.48, wherein the combination of Het, R, R2, R3 and R4 corresponds in each case to one of the above Table A.

149026.doc •119- 201103429

[SI 149026.doc 120 201103429

In these compounds, the compound is preferably a compound ιν ι to ιν 24, more preferably a compound IV. 1 to IV. 12 ‘ even more preferably a compound IV” and IV 2 and particularly preferably a compound IV.2. The invention further relates to an agricultural composition comprising at least one compound of formula I, ^ and/or ^ as defined above, or a salt thereof and a liquid or solid carrier of agriculturally acceptable 149026.doc • 121-201103429. Suitable carriers and auxiliaries and other active compounds which may also be included in the compositions of the invention are as defined below. The compounds I and II and IV and the compositions of the invention are each suitable as a fungicide. It is characterized by significant effectiveness against a wide range of phytopathogenic fungi, including soil-borne fungi, especially from the following categories: Plasm〇di〇Ph〇r〇myCetes, Oomycetes (per〇n〇) Sp〇r〇mycetes, 〇〇mycetse), Chytridi〇mycetes, zyg〇mycetes, Asc〇mycetes, Basidiomycetes, and Deuteromycetes Deuter〇myce (4) (7) The term "Fungi imperfecti". Some of them are systemically effective and can be used as crop fungicides, seed dressing fungicides and soil fungicides for crop protection. In addition, it is suitable for controlling harmful fungi, especially fungi that occur in the roots of wood or plants. The compounds and the compositions of the present invention are particularly important in controlling a large number of plant-derived fungi: fungi on various cultivated plants, such as alfalfa such as wheat, rye, barley, triticale, oats or rice; beets, For example 'sugar beet or beet; fruit, such as pome fruit, stone fruit or soft fruit, ❹, rhyme, pear 'plum, peach, almond, phase peach', black per vine or gooseberry; legume Plants, such as lentils, peas, cockroaches, or cockroaches; oil crops, such as rapeseed, glutinous rice, black sandalwood, 曰Cai, coconut, cocoa, lotus, oil palm, groundnut or soybean; light such as pumpkin, Cucumber or melon; fiber plant, such as cotton, sub-hemp or jute; mandarin (four) fruit, such as material, lemon, grape cypress or mandarin 'vegetables, _ vegetables, geese [dong tube, kale, carrot, [S M9026.doc •122- 201103429 Onion, tomato, potato, melon 龅 _ a melon cheek or pepper; laurel plant 'such as avocado vegetable banana wood, · a ·, , «_ · ~ 53⁄4 戈〇肉(4) camphor; energy and raw materials such as jade , soybean, oil cane or oil palm; corn; tobacco; nuts; coffee; eucalyptus vines (fresh grapes and grape vines); hops;; 'natural rubber plants or ornamental plants and forestry plants, such as flowers, Perfusing broadleaf trees or evergreen trees such as conifers; and fungi such as seeds on plant propagation materials and crop materials of such plants. Preferably, the compounds 11 and 1 and their compositions are used to control the following A large number of fungi on the field: field work "Do not _ such as potatoes, sugar beets, grass, wheat, rye, barley, oats, rice, corn, cotton, big ugly, rape, beans, geranium, coffee or sugar cane; Fruit; vines; ornamental plants; or vegetables, such as hu, melon, garnish, or pumpkin. It should be understood that the term "plant breeding ancestor _ reproductive material" table may not be used to propagate all plant pure materials, such as materials, and nutritive (four) materials, such as cuttings and tubers (such as potatoes). This includes seeds, roots, fruit notes, stems, «, rhizomes, branches, young shoots and other parts of the plant, including 2: Putian' which is transplanted after germination or after exposure to the soil. It can also be used to protect these preferably by using the compound or the composition of the composition, and to treat the following materials, respectively, by means of all or part of the treatment by dipping or pouring. Bacteria, such as wheat buckwheat, barley and oats; rice, corn, cotton and soybeans. The term "cultivated plants" is to be understood to include or genetically engineered modified plants, including the heart);: = 149026.doc -123· 201103429 Agricultural biotechnology products in the market (Reference: http://www.bio. Org/speeches/pubs/ er/agri_products.asp). Genetically modified plants are plants whose genetic material has been modified by the use of recombinant DNA techniques which, in the natural case, are not readily obtainable by cross breeding, mutation or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant to improve certain properties of the plant. Such genetic modifications also include, but are not limited to, proteins by, for example, glycosylation or polymer addition (such as prenylated, acetylated or farnesylated moieties or PEG moieties). Post-translational modification of the oligopeptide or polypeptide.

Plants that have been modified by breeding, mutation induction or genetic engineering are resistant to the application of specific classes of herbicides, such as hydroxyphenylpyruvate dioxygenase, by conventional breeding or genetic engineering methods (for example). Inhibitor of acetaminophen lactic acid synthase (ALS), such as sulfonium urea (see, for example, US 6,222,100, WO 01/82685, WO 00/26390, WO 97/41218, WO 98/02526, WO 98 /02527, WO 04/106529, WO 05/20673, WO 03/14357, WO 03/13225, WO 03/14356, WO 04/16073) or imidazolinones (see for example US 6,222,100, WO)

01/82685, WO 00/026390, WO 97/41218, WO 98/002526, WO

98/02527, WO 04/106529 'WO 05/20673, WO 03/014357, WO 03/13225, WO 03/14356, WO 04/16073); enol acetone oxalic acid-3-phosphate synthase (EPSPS) Inhibitors, such as glyphosate (see, for example, WO 92/00377); flavonoid synthase (GS) inhibitors, such as glufosinate (see, for example, EP-A 242 236, EP-A) 242 246) or oxynil herbicides (see for example US

[SI 149026.doc -124- 201103429 5,559,024). Conventional breeding methods (mutation induced) have rendered several cultivated plants resistant to herbicides such as Clearfield® Summer Canola (Canola, BASF SE, Germany) to glutinous rice. Selenone (for example, 曱 σ σ 于 于 (imazamox)) is financially acceptable. Genetically engineered methods have been used to render cultivated plants (such as soybeans, cotton, corn, sugar beets, and canola) tolerant to herbicides (such as galaxin and chlorpyrifos), some of which are under the trade name RoundupReady®. Monsanto, USA) and LibertyLink® (commercially available, Bayer CropScience, Germany) are commercially available. Also included are plants capable of synthesizing one or more insecticidal proteins by using recombinant DNA techniques, especially from the genus Bacillus (genus 5i?cz7/ws), especially from Bacillus thuringiensis i/zwr/wg/ e) protein such as δ-endotoxin, for example, CrylA(b), CrylA(c), CrylF, CryIF(a2), CryIIA(b), CrylllA, CrylllB(bl) or Cry9c; vegetative insecticide Protein (VIP), such as VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of colonizing nematode bacteria (eg, Photobacterium (jP/zoior/zaZjc/ws spp.) or Nematophagous sp.) a toxin produced by an animal, such as a moth toxin, a spider toxin, a wasptoxin or other insect-specific neurotoxin; a toxin produced by a fungus, such as a toxin, a plant lectin, such as cowpea or barley agglutinin; Lectin; protease inhibitors such as trypsin inhibitors, serine protease inhibitors, patatin inhibitors, cysteine protease inhibitors or papain inhibitors; ribosome-inactivated proteins (RIP) ), such as ricin Yuxi-RIP, acacia, loofahin, saporin or diarrhea toxic protein 149026.doc -125 - 201103429 such as 3-hydroxysteroid oxidase, deoxygenase, cholesterol oxidase, ecdysone inhibitor Channel blocker 'such as sodium channel (bryodin); steroid metabolism enzyme, dermal steroid-IDP-wall transferase preparation or HMG-C〇A-reductase; or calcium channel blocker; juvenile hormone esterase; diuretic Hormone receptor (heterologous genus protein receptor); K synthase, biphenyl thiol synthase, chitinase or glucanase. It is also expressly understood in the context of the present invention that such insecticidal proteins or toxins are understood to be protoxins, hybrid protein truncations or otherwise modified protein hybrid proteins characterized by novel combinations of protein domains (see, for example, W0 〇 2 /〇157〇1). Other examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, for example, in EP-A 374 753, WO 93/007278, WO 95/34656, EP-A 427 529, EP-A 451 878, WO 03/18810 and WO 03/52073. Methods for producing such genetically modified plants are generally known to those skilled in the art and are described, for example, in the above publication. Such insecticidal proteins contained in genetically modified plants allow plants producing such proteins to tolerate harmful pests from all: arthropod taxa, especially beetles (Coleoptera), two-winged insects (double wings) Diptera) and moths (Lepidoptera), and nematodes (Nemat〇da). Genetically modified plant lines capable of synthesizing one or more insecticidal proteins are described, for example, in the above publications' and some of them are commercially available: such as YieldGard® (a corn cultivar producing CrylAbsulin), YiiedGard® Plus (produced)

Corn cultivar of CrylAb and Cry3Bbl toxin), Starlink® (Cry cultivar producing Cry9c glutinin), Herculex® RW (production of 0^34 八131, (:735 into 1)1 and enzyme phosphine||麻碱_: ^_Acetyltransferase [?8:] [S1 149026.doc -126-201103429 corn cultivar); NuCOTN® 33B (cotton cultivar producing CrylAc toxin), Bollgard® 1 (cotton producing CrylAc toxin) Cultivars), Bollgard® 11 (cotton cultivar producing CrylAc and Cry2Ab2 toxins); VIPCOT® (cotton cultivar producing VIP-toxin); NewLeaf® (potato cultivar producing Cry3 A toxin); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Btll available from Syngenta Seeds SAS, France (eg Agrisure® CB) and Btl 76 (corn cultivar producing Cry lAb toxin and PAT enzyme), from Syngenta Seeds SAS MIR604 (a corn cultivar producing a modified form of Cry3 A toxin, see WO 03/018810), MON 863 (a corn cultivar producing Cry3Bbl toxin) purchased from Monsanto Europe SA·, Belgium, Mo Nsanto Europe S.A., Belgium's IPC 53 1 (cotton cultivar producing a modified form of CrylAc toxin) and 1507 (a corn cultivar producing CrylF toxin and PAT enzyme) purchased from Pioneer Overseas Corporation, Belgium. Also included are plants which are capable of synthesizing one or more proteins which increase the resistance or tolerance of their plants to bacterial, viral or fungal pathogens by using recombinant DNA techniques. Examples of such proteins are the so-called "pathogenesis-related proteins" (PR proteins, see for example EP-A 392 225), plant resistance genes (for example, horse yam cultivars, which are used for Against a resistance gene derived from the potato Phytophthora infestans from the Mexican wild potato diploid variety {Solarium iawww) or T4-lysozyme (for example, a potato cultivar capable of synthesizing such proteins, such as pear fire injury _ pathogens (Five rwzWa izm_y/vora) bacterial resistance increased 149026.doc -127- 201103429 plus). Methods of making such genetically modified plants are generally known to those skilled in the art and are described, for example, in the above publication. Also included are plants capable of synthesizing one or more proteins by using recombinant DNA techniques that increase productivity (eg, biomass production, grain yield, starch content, oil content or protein content), drought tolerance, Salt tolerance or tolerance to other growth limiting environmental factors or to fungi, bacterial or viral pathogens of pests and their plants. In addition, in order to specifically improve the nutritional status of humans or animals, plants comprising varying amounts of inclusions or novel inclusions by using recombinant DNA techniques, for example, to produce healthy long-chain ω-3 fatty acids or unsaturated ω -9 fatty acid oil crops (eg, Nexera® canola,

Agro Sciences, Canada) ° In addition, in order to specifically improve the production of raw materials, plants containing varying amounts of inclusions or novel inclusions by using recombinant DNA techniques, for example, horses producing increased amounts of amylopectin Sweet potato (for example, AmHora is at the age of 'BASF SE, Germany). Compounds I, II and IV and their compositions are especially suitable for controlling the following plant diseases: White rust pathogen 〇 4/6 sigh spp.) (white rust): in ornamental plants, Zhao dishes (for example, rape white rust pathogens) (A heart)) and hollyhock (for example, Brahman white rust (Children; Alternaria spp.) (Alternaria leaf spot): in the vegetable 'Rapeseed (Children, sugar beet (A. tenuis), fruit, rice bran, soybean, potato (for example, horse yam, I49026.doc -128- 201103429) /am·) or Alternaria alternata (丄 tomato (for example, Alternaria alternata or Alternaria alternata) and wheat; sugar beet and & root rot pathogen spp_); The genus Spirulina spp.) on moss and vegetables, for example, wheat ring rot fungus 小麦 4 · anthracnose on wheat and barley rot hordei on barley) 'Bip〇laris 5 rush) ruminant umbilical genus spp.) (has a sexual state: C. cerevisiae (C〇CW〇h/Mi spp.)), for example, southern leaf blight on corn (maize long creep (叮山〇) or northern leaf blight (corner umbilical larvae of corn) (and, for example, 'spot disease on cereals (wheat root rot (5)) and rice snails on rice and turf Spores (and or^yzae); powdery mildew on alfalfa (such as wheat or barley) (5/wweWa grawn.wbK formerly known as Wuzhi^>xin powdery mildew); fruits and berries (eg, strawberries), Vegetables (eg, lettuce, carrots, celery and kale), rapeseed, flowers, vines, forestry plants and Botrytis cinerea on wheat (7) Heart Wea) (have a state: Botrytis cinerea (...) (10)_ /wc know (6)(10) ): Gray M), lettuce oncuce on lettuce (5re/wz.a Mciwc < 2e) (downy mildew); broad-leaved tree and evergreen tree genus spp) (synonym long genus spp. )) (rot or wither), such as C. w/mi on the eucalyptus (Dutch eucalyptus); Cerc〇5p〇rfl spp_ (leaf leaf spot): in corn (eg, gray leaf spot: gray leaf spot (C, rice bran, sugar beet (eg, beet brown spot (C. Z> e〇C〇/i7)), sugar cane, Vegetables, coffee, soybeans (for example, Phytophthora sojae (C Μϋα) or Phytophthora sojae (c and rice blast; black 149026.doc • 129· 201103429 genus spp.): in tomato (for example, leaf blackening) Pathogens (C. / Wvwm) • Leaf disease) and cereals such as wheat-specific wheat (C. / zdarMm) (smut); ryegrass on clams (c/aWce^ Pwrpwr () ergot); genus genus (Coc/z/z〇Z) 〇h^ spp.) (non-sexual snail snail) (C. carhwMm), mites (eg, Helicobacter pylori (C. /ί/νΜ·?), asexual: wheat root rot, umbilical cord worm (where sorokiniana)) And rice (for example, Helminthosporium cerevisiae (c (10)' asexual state · Helminthosporium hirsutum (/ / 上;; Phytophthora (Co//eioir/c/2wm spp.) : Anthracnose (G/omerWa Spp_)) (anthrax): in cotton (for example, C. sinensis (cg〇;; household (7)), corn (eg 'P. sinensis (c • (1)·c〇) /a): anthrax stem rot), soft fruit, potato (for example, fruit rot . coccoi/e·?). black spot), beans (for example, Phytophthora sojae (c. /MAmwi/n·(10))) and soybeans (for example, sphaerocephala (c (10)) or spores Anthracnose (C. g/oeosporioic/e·?)); Phytophthora spp.) 'For example, Rhizoctonia solani (c μ 仏 ·) on rice (stained blight); soybean and ornamental plants Phytophthora sojae (c〇AT„eip〇ra Cai^7c〇/a) (leaf leaf spot); Cycl〇c〇nium spp., such as on the oil-removing tree Oil withdrawal from C. elegans (C. ο/eag/WMW); Pseudomonas (C_y" «do οαν(10)spp.) (for example, fruit tree cancer or vine decline, morphological: Arecirk SPP. or iVeoweciWa spp.: in fruit trees and vines (for example, the stalk of the palm stalk (C., sexual state: 揪掌揪149026) .doc •130- 201103429 Phytophthora capsici (A/ecmec/rz.a /z>z'oc^«drz'): Blackfoot disease) and ornamental plants on 'S. cerevisiae (£) E-mail (7) (7),) (has a sexual state: C. serrata (iJoje/hWa/ecaWx) ) (root rot and stem rot); D/apori/ze spp_, for example, D. phieo/or on the soybean (D· phieo/or please) Spore "synonymous genus Helminthus" has a sexual state: nucleocapsid: in corn, mites, such as barley (for example, umbilical umbilical (/) ierei), and wheat (such as ' Xingxian wheat snails (£)· Bu (1) c span's, brown spot)), rice blast and turf; EsCa (top blight, dry blight) on vines, by spot ritual {Formitiporia punctata , Phellinus punctata"), Mediterranean bacterium (F., Fusarium faecalis) (housekeeping / postal 〇 & & / / 3 3 3 3 3 3 3 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期 早期Phaeoacremonium chlamydosporum)), parasitic bottle mold (P/zfleoflcr (4) omwm fl/eop/n'/ww) and/or Botryosphaeria obtusa, bowed, M genus (Ehin〇e SPP) .). in Renguo (Pear Helicobacter pylori (5.p;; rz·)), soft fruit (P. sylvestris (£. veneia: anthracnose) and vine (V. serrata) /ina): Rickets), on the rice stalks, the black leaf disease of the rice leaf (heart such as 〇 〇 〇〇 ^e) (leaf smut); the genus of black bacterium in the wheat (5 〆 c〇cc_ SPP.) Disease) 'Ginkgo genus (five spp.) (powder disease): in sugar beet (Beet powdery mildew (£. Z^iae)), vegetables (for example, pea powdery mildew (£_pw)), such as melon (for example, two white powdery mildew (five / zoraceawm)), cabbage (canola) (for example, crucian powdery mildew (£· cr«c such as rarim)), in fruit trees, vines and ornamental trees 149026. Doc • 131 · 201103429 More than C. oxysporum (five grape cancer or top blight, asexual: polycystis/αία) (synonym: Lz·heart rie/M 6/ep; 2arb))); in the corn (for example, the large spotted umbilical bacterium (£· iwrchm)), the genus Umbra (ExSerohilum spp, synonymous snail); Helicobacter (7^like aWww spp) (having a sexual state: Gibberella sPP.)) (wild wilt, root rot or stem rot), such as cereals on the genus (eg wheat or barley) Spore Inearum) Fusarium oxysporum ^ (F. Culmorum ^ root rot, sore ill or head blight), Fusarium oxysporum π oxj^porwm on tomato, Fusarium solani on soybean Phytophthora (feet (1).) and Fusarium oxysporum (plant verAz7/ioWej) / mites (such as wheat or barley) and Phytophthora capsici on corn (Gaewwa/mo less cei full button disease) , Gibberella spp·): on mites (eg, Zew root zewing), and rice (eg, G. wy^wroz): locust disease, vines, kernels Anthracnose on fruit and other plants (G/〇 π - and cotton phlegm on cotton (G· g〇|Si^pZ'z'). Grans staining complex on rice (Grainstaining complex) ); the sputum of the genus Coccinella on the vine (black rot), the genus spp. on the genus Rosaceae and the juniper, such as the Sabin rust on the pear (G. (rust) , · Corn, scorpion and long genus on the rice stalk (synonym umbilical sarcophagus 'has a sexual state: Helminthosporium), rust genus (//ewi/em spp.), such as coffee Helminthosporium rust (open coffee leaf rust) ,. Phytophthora infestans on vines (/Yong _A c/aW printed ora) (synonymous grape mutans (cw〇v〇rz. 149026.doc •132-201103429

Wi/s)) / Soybean and cotton on the bacterium (Macrc > jc > / zc > mz · phasephase, Macrophomina phaseoli) (root rot anti-1 rot); on cereals (such as wheat or barley) Snow rot microbe nodules (M/crc?t/oc/^ww mWe) (synonym Fwiarz'wm «iva/e) (snow emblem), · Huanghua shawl on soybean Silk shell (A/7cr〇i_p/z<3era powdery mildew); brown rot (Mom7zWa spp.), for example, stone fruit rot and other brown plants on the Rosaceae plant (Μ· /(3X<3), US-Australian type of brown rot fungus (M. /rwchco/a) and brown rot fungus (M (flower rot and twig blight, brown rot); mites, bananas, soft fruits And Mycosp/zaereZ/a spp. on the groundnut, such as the bacterium of the genus M. granulosus (M. ramzWco/a) (non-sexual state: wheat sclerotium, acicular plaque Disease (Septoria blotch), or Filipino sclerotium on banana (Μ black banana leaf spot), Downy mildew (Pero (10) printed ora spp.) (downy mildew): in cabbage (such as canola cream Disease (Ρ. brawicae)), rapeseed ( Such as parasitic downy mildew (P. / jaran'hca), onions (such as P. ☆ yirwcior), grass (P. i (30ack < 3)) and soybeans (such as soybeans) Downy mildew (corpse.ma/^/zwrica)); Pleurotus ostreatus on soybean (P/zaAoporo! p<3c/2_yr/n'zi·) and mountain horse*Pymeibomiae (Soybean rust) I PhiaZophora spp.: for example, in vines (eg, piperculosis (P. ir<3c/ze(p/2//(3)) and Tetrasporium (Ρ· And soybeans (eg, P. gregaia: stem rot); P. sphaeroides (P/zom < 3 /z'/igam) on rapeseed and cabbage (root rot and stem) Rot), and sugar beet on the beet stem mold (house 6 to) (root rot, leaf spot and blight), P. sinensis 149026.doc -133- 201103429 P/zomopWi spp.): to the hollyhock, vine (such as P. sphaeroides (/> Whco / α): leaf spot disease (can and ieaf spot) and soybeans (such as stem rot: Beans and Phomopsis molds (/>·If still printed (7), there are sexual states: Phytophthora sinensis; Potamoca sinensis on rice; mountain \?) (brown spot disease); Phytophthora spp.) (wild wilt, root, leaf, fruit and stem rot) on various plants: Melons (such as Phytophthora capsici (pc 叩 z)), soybeans (such as Phytophthora sojae (i>., household, horse yam and Fan Li S (such as Phytophthora infestans (/>· /Caga Like): late blight) and broad-leaved trees (such as Phytophthora sojae (R. ramorwm): oak tree death); Brassica campestris, rapeseed, radish and other plants on the roots of Phytophthora (ρ/αι^〇Α·σ ;?/2〇π such as _cae) (root swollen disease) / unicorn mold (ρ / α 叩 spp.), such as vines on the vines of the unicorn mold (W · Wn.co / a) (grape Rattan downy mildew), and the Helicobacter pylori on the hollyhock (household; Rosaceae, hops, pomegranate, and soft fruit) /2απα Spp.) (powder disease), such as the white sclerotium on the apple (H. / ewcoiric / za); polymyxa (/ > c) / _yWyxa spp.), for example in the mites (such as barley and wheat) (polymyxobacteria (household and sugar beet ( P. feeiae) and viral diseases transmitted by it, 蔓 ( ( ( ( ( ( her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her her State: Tapesia γα11ιιηάα^ ., known as the downy mildew mildew on plantings, such as pumpkin squash on the melon (cwijewh??) or shamrock on the hops (household /2) Said)); vines on the vines

t SI 149026.doc •134- 201103429 (PmW叩kac/^&gt;/nVc〇 (red fire disease (red generation disease) or rotbrenner, asexuality. Bottle mold, Phytophthora on various plants (PMccz 'm'a spp.) (rust), such as wheat rust fungus (/&gt; 斤出•^• heart) (brown rust or leaf rust), strips on cereals (eg wheat, barley or rye) Rust fungus (P. stripe rust or yellow rust), malt rust (household / zorc? ei) (dwarf rust), rust rust (houser. (stem rust or black rust) Or concealed rust fungus (household (brown rust or leaf rust), and rust fungus on asparagus (such as asparagus rust fungus (household avar sigh); wheat on the yellow spot wheat nucleus bacteria (hu Shaogang heart ~ irziwzrepe « along) (non-sexuality: Helminthosporium umbellata (Drec/^/era brown spot) in the yellow spotted wheat or the nucleus of the genus on the barley (housekeeping ^) (net spot disease), · Pear Genus (i&gt;rz'cw/aWa spp.), such as P. sphaeroides (/*. or less zae) on rice cultivars (having sexuality, rice and rice pain, rice cancer, disease) and turf and extinction Grifola sinensis (/&gt;.; turf, rice, corn, Wheat, cotton, canola, hollyhocks, soybeans, sugar beets, vegetables, and various other plants of the genus Spp.) (Phenosis) (eg Pythium pyogenes (P. M/i/mMw) or Pythium genus (/&gt;. aphanidermatum), so it is full of genus (Ramularia spp.), such as Klein column on the barley (brother coZ / ocygm.) (S. sphaeroides leaf spot) , physiological leaf spot) and the sugar beet on the beetle sclerotium (brother; cotton, rice bran, horse yam, turf, corn, rape, potato, sugar beet, vegetables and various other plants on the silk Rhizoctonia spp.), such as Rhizoctonia solani (and ._5〇/(10)/) (root rot and stem rot), Rhizoctonia solani (strain) or wheat or barley on rice I49026.doc • 135· 201103429 The Rhizoctonia cereal (/?. cerea/b) (Spring blight); lychee on strawberries, carrots, kale, vines and tomatoes Rhizopus (and /n'zopMs (black mold disease 'soft rot), barley, rye and black wheat on the rye sclerotium called brown spot disease), rice blast on the rice stalk Aroc/aAwm oryzae) and Rhizoctonia solani (51·(10)aiwm) (slightly rot); Sclerotinia (•Sderoikk spp.) (stalk rot or white mold): in vegetables and field crops, Such as rapeseed, geranium (such as Sclerotinia sclerotiorum (S. π & Γ〇η·〇ΓΜ / η)) and soybeans (such as sclerotium sclerotium (iS r〇 / yw〇 or Sclerotinia sclerotiorum) Upper; Phytophthora on various plants' such as Glycyrrhiza glabrata (&amp; _^ζ·πα) (brown spot) on soybean, and Saccharomyces cerevisiae on wheat (&gt ;s out of () scleroderma) and scorpion sclerotium (iS·.(10) and (3)) (synonymous lyrics (iSYagowowora 〇i/orww) ) (shell plaque), vines on the vines of the genus weca (or) (synonym grape powdery mildew > less ^ &gt; / ^ «ecaior)) (powder disease, asexual state : Chrysosporium sinensis (Ch'cZ/wm iwcA: er/)); Phytophthora spp.) (leaf blight): in corn (eg, &amp; iwrdcwm), synonym Heiminihosporium turcicum, anti-skin _L ', black-stable disease Genus (•Sp/mce/oi/zeca spp.) (smut): in corn (eg, corn smut (<S rei/z*a; 7£z): silk smut (head smut)), sorghum and sorghum borrowed potato sclerotium from the 'Me/Milo/zeca /w/4/«ea' (powder disease) potato on the melon OWgOiSp0ra (white disease) and the viral disease transmitted thereby; the genus Pseudomonas on the cereal, such as the sclerotium on the wheat ($· 多 抱 菌 plaque,

[s I 149026.doc -136- 201103429 modality. Phytophthora vaginalis ποί/orwm) [synonym for Pseudomonas sinensis (PZ/aeoip/meha; endophytic chytrid on horse yam "c/zyWww potato cancer disease"; genus [Taphrina spp.), such as the deformed outer sac of the peach (plant leaf defect) and the outer bacterium of the plum on the plum (r (1) ·) (Li capsule Disease), the genus Rhizopus on the grass, pome fruit, vegetables, soybeans and cotton (772k/izWo; ^·5 spp.) (black root rot), such as Toxoplasma gondii (adcoM) (synonym) Elegant Phytophthora infestans (C; m/iJra; sorghum genus (77//eik spp.) on cereals (common smut or stinking smut), such as wheat stalks on wheat Smut (r ~ ~ /) (synonym T. caries, wheat smut) and dwarf smut (Γ. cowirover ^) (dwarf smut); barley or wheat Rhodopseudomonas palustris (10)M) (Glyph of snow ash); smut ssp.), such as rye smut on rye, μ(3)-) (stalk smut), · single on vegetables Spore rust (t/r〇WCa spp.) (rust disease) 'such as beans (such as the sclerotium sclerotium ... "ie (9) heart (3) / plus), the synonym of Phytophthora sinensis (( / 0 such as (9) (7)) and sugar beet (such as sweet menu ore (t/. 0eme)); smut (¢/扣7〇 sPP.) (loose smut): in mites (such as smut (t/. (10)) And oat smut (t/., corn (such as maize smut) (ίλ speaks ··· : corn smut) and sugar cane; Helicobacter (Rwwk sPP.) (scared disease): in apple (eg, apple black bacillus (K ka called wa/b)) and pears; and the body of various planted sorghum plants (such as fruits and ornamental plants, vines, soft fruits, vegetables, and intercropping crops) Withering disease 149026.doc -137· 201103429 genus (KemW/Hwm spp.) (wild wilt), such as strawberry, rapeseed, horse-to-potato and tomato on the pathogen (K, /2 / ke). I, II and IV and their compositions are also suitable for controlling harmful fungi in the protection of stored products or harvests and protective materials, respectively. The term "protective material" should be understood as Underlying technical and non-biological materials to combat the infestation and destruction of valuable microorganisms such as fungi and bacteria: such materials as adhesives, glues, wood, paper and cardboard, textiles, leather, paint dispersions, plastics, cooling lubrication Agents, fibers or fabrics. For the protection of wood and other materials, special attention should be paid to the following harmful fungi: Ascomycetes, such as Op/n'o Woma spp., Spirulina spp. Mold (dwreoftasWww pw/Zw/a; ^), Sclefophoma spp., Chaetomium spp., Humicola (i/wmico/α spp.), Peter's genus (corporate eir/e/M spp.), genus genus (7&gt;&amp;/2μγμ·5 spp·); basidiomycete 'such as Helicobacter spp.; spp.), genus Corio/ws spp.), Pleurotus spp.), Citrus spp.), Pleurotus spp., Por/α spp., Serpent/iz Spp.) and Cases (7&gt;row_yce;s spp.); deuteromycetes, such as the genus Sputum spp.), genus Helicobacter, Penicillium (Pen/ci/ZiMm spp.), wood emblem Phytophthora spp.) Genus, Paecz'/omyca spp. and zygomycetes, such as Mwcor spp., and in addition to protecting stored products and harvests, the following yeast fungi should be noted: Candida (Ca) «Mountain 'c/α spp.) and Saccharomyces cerevisiae [S] 149026.doc • 138- 201103429 Compounds I, II and IV and their compositions, respectively, can be used to improve the health of plants. The invention also relates to a method for improving the health of a plant by treating the plant, its propagation material and/or the place where the plant is grown or to be grown, in an effective amount of the compound I, II and/or IV, and combinations thereof, respectively. . The term "phytosanitary condition" is understood to mean the condition of a plant and/or its products, which is determined by several indicators, either alone or in combination with each other: such as yield (eg, increased biomass and/or increased content of useful ingredients), Plant growth [eg, plant growth. Improvement and/or greener leaves ("greening effect"), quality (eg, improved content or composition of certain ingredients), and abiotic and/or biological adversity Tolerance @. The indicators of plant health status above may be interdependent or mutually damaging. The compounds of formulas I, II and IV may exist in different crystalline variants (which may differ in biological activity). Also the subject matter of the invention. When a fungus or plant, plant propagation material (such as seeds, soil, surface, material or room) is treated with a fungicidally effective amount of active substance to protect it from true g attack The limbs (4) are used as they are or in the form of a composition to make f in plants, plant propagation materials (such as seeds, soil, materials or rooms) before and after fungal infections. Administration: It can be prevented by compound J, π and/or 1 ¥ in the plant or transplanted 1 or in combination with a compound containing at least 彳 人 ^ 化合物 compound 1, II and / or IV The invention relates to the treatment of plant propagation materials. The invention also relates to agrochemical compositions comprising a solvent or a solid carrier and at least one compound and or IV and for controlling harmful fungi. 149026.doc • 139· 201103429 Agrochemical composition A fungicidally effective amount of Compound I, II and/or IV is included. The term "effective amount" means a compound I, II and/or IV which is sufficient to control harmful fungi or protective materials on cultivated plants and which does not substantially harm the treated plants. The amount of the composition or compound I, II and/or IV. The amount can vary within wide limits and depends on various factors such as the type of fungus being treated, the cultivated plant or material being treated, the climatic conditions, and the particular compound I used. The compounds I, II and IV and their salts can be converted into conventional agrochemical compositions such as solutions, emulsions, suspensions, powders, powders, pastes and granules. The type of composition will depend on the particular intended purpose; in each case, it will be ensured that the compounds of the invention are finely and uniformly distributed. Examples of composition types are suspensions (SC, OD, FS), emulsifiable concentrates (EC), emulsions (EW, EO, ES), pastes, tablets, wettable powders or powders (WP, SP, SS, WS, DP, DS) or particles (GR, FG 'GG, MG), which may be water soluble or wettable, and gel formulations for treating plant propagation materials such as seeds. The type of composition (e.g., SC, OD, FS, EC, WG, SG, WP, SP, SS, WS, GF) is typically used after dilution. The type of composition (such as DP, DS, GR, FG, GG, and MG) is usually used without dilution. The composition is prepared in a known manner (see, US 3,060,084, EP-A 707 445 (Liquid Concentrate), Browning: "Agglomeration", Chemical Engineering, December 4, 1967, 147-48, Perry's Chemical Engineer's Handbook, 4th edition, McGraw-Hill, New York, 1963,

Pages 8-57, following pages, WO 91/13546, US 4,172,714, US

[S] 149026.doc -140· 201103429 4,144,050 ^ US 3,920,442 ' US 5,180,587 ' US 5,232,701 &gt; US 5,208,030 'GB 2,095,558 ' US 3,299,566 &gt; Klingman: Weed Control as a Science (J. Wiley &amp; Sons, New York, 1961), Hance et al.: Weed Control Handbook (8th ed., Blackwell Scientific, Oxford, 1989) and Mollet, H. and Grubemann, A: Formulation technology (Wiley VCH Verlag, Weinheim, 2001)). Agrochemical compositions may also contain conventional adjuvants in agrochemical compositions. The auxiliaries used will depend on the particular application and the active substance. Examples of suitable auxiliaries are solvents, solid carriers, dispersants or emulsifiers (such as other solubilizers, protective colloids, surfactants and binders), organic and inorganic thickeners, bactericides, defenses; Agents, defoamers, (if appropriate) colorants and tackifiers or binders (for example, for seed treatment formulations). Suitable solvents are water; organic solvents such as medium to high boiling mineral oil fractions such as kerosene or diesel; in addition to coal tar and oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons such as toluene, Toluene, paraffin, tetralin, alkylated naphthalene or derivatives thereof; alcohols such as decyl alcohol, ethanol, propanol, butanol and cyclohexanol; glycols; ketones such as cyclohexanone and γ- Butyrolactone; fatty acid dimethylamine, fatty acids and fatty acid esters and strong polar solvents such as amines such as anthracene-fluorenyl. Than each biting ketone. The solid carrier is mineral soil, such as silicate, tannin, talc, kaolin, limestone, lime, chalk, red basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide; Synthetic materials; fertilizers such as ammonium sulphate, ammonium phosphate, ammonium nitrate, urea; and plants 149026.doc -141 - 201103429 Source products, such as cereal meal, bark meal, wood meal and nut meal, cellulose Powder; and other solid carriers. Suitable surfactants (adjuvants, wetting agents, tackifiers, dispersants or emulsifiers) are aromatic sulfonic acids (eg lignin sulfonic acid (B〇rresperse &lt;&amp; type, Borregaard, Norway), phenolic sulfonic acid , naphthalene sulfonate type, Akz〇

Nobel, USA) monobutyl phthalate (Nekal® type, BASF Germany) and alkali metal, alkaline earth metal and ammonium salts of fatty acids; alkyl sulfonates, alkyl aryl sulfonates, alkyl sulphates Salt, lauryl ether sulfate, fatty alcohol sulfate; and sulfated cetyl alcohol, heptadecyl alcohol and stearyl alcohol salt, sulfated fatty alcohol glycol ether, in addition to naphthalene or naphthalenesulfonic acid and phenol And furfural condensate, polyoxyethylene octyl phenyl ether, ethoxylated isooctyl octyl age, bismuth base, pyridyl phenyl polyethylene glycol test, tributyl phenyl polyglycol ether , tristearyl nonyl phenyl polyglycol ether, alkyl aryl polyether alcohol, alcohol and fatty alcohol / ethylene oxide condensate, ethoxylated dry sesame oil, polyoxyethylene alkyl ether, ethoxy Polyoxypropylene, lauryl polyethylene glycol ether acetal, sorbitol ester, lignin sulfite waste liquid and protein, denatured protein, polysaccharide (for example, mercapto cellulose), hydrophobic modified starch, Polyvinyl alcohol (Mowiol® type, Ciariant, Switzeriand), polycarboxylate (S〇k〇ian® type, BASF, polyalkoxylate, Polyvinylamine (pas〇l type, BASF, Germany), polyethylene η pirone and its copolymer.

The example of the thickening agent (that is, the D which imparts improved fluidity to the composition, that is, the high viscosity under static conditions and the low viscosity during the oscillation) are polysaccharides and organic and inorganic clays, such as three. Celery (Kelzan@, CP

[S] 149026.doc •142· 201103429

Kelco, U.S.A.) ^ Rhodopol® 23 (Rhodia, France) ^ Veegum® (R.T.

Vanderbilt, USA) or Attaclay® (Engelhard Corp. NJ, USA). A bactericide may be added to preserve the composition and stabilize the composition. Examples of suitable bactericides are those based on dichlorophenol and stupid methanol hemi-reducing Aldehyde (Proxel® from ια or Acticide® RS from Thor Chemie and Rohm &amp; Haas

Kathon® MK) is a bactericide and an isothiazolinone derivative such as an alkyl lacquer. Selenone and benzisothiazolinone (Acticide® MBS from Th〇r chemie). Examples of suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin. An example of a defoaming agent is a polyoxyl emulsion (such as SUik〇n® SRE,

Wacker, Germany or Rhodorsil®, Rhodia, France), long chain alcohols, fatty acids, fatty acid salts, fluoroorganic compounds and mixtures thereof. Suitable colorants are low water soluble pigments and water soluble dyes. Examples mentioned and named are rh〇damin B, c pigment red m, C丄 solvent red 1, pigment blue 15:4, pigment blue 15:3, pigment blue 15:2, pigment Blue 15:1, Pigment Blue 80, Pigment Astragalus, Pigment Yellow 13, Pigment Red ΐ2, Pigment Red 48:2, Pigment Red 48:1, Pigment Red Blade], Pigment Red 53:i, Pigment Orange 43, Pigment Orange 34, Pigment Orange 5, Pigment Green%, Pigment Green 7, Pigment White 6, Pigment Brown 25, Test Purple 10, Basic Violet 49, Acid Red 51, Acid Red 52, Acid Red 14, Acid Blue 9, Acid Yellow 23, testability (four), test red 108. An example of a binder or binder is polyethylene. Ratio of slightly, polyethylene acetate vinegar, polyethylene glycol and cellulose (5) (10) 'He (four) India, called Ling can be by compound 1 and (if appropriate) other active substances with at least - seed 149026.doc • 143 · 201103429 The bulk carrier is mixed or accompanied by grinding to prepare powders, dispersion materials and powders. Granules can be prepared by binding the active material to a solid carrier, for example, coated granules, impregnated granules, and homogeneous granules. Examples of solid carriers are mineral soils such as tannin, silicate, talc, kaolin, activated clay, limestone, lime, chalk, red basalt, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate. , magnesium oxide; ground synthetic material; fertilizer, such as ammonium sulfate, ammonium phosphate, ammonium nitrate, urea; and plant-derived products, such as glutinous meal, bark meal, wood meal and nut meal, cellulose Powder; and other solid carriers. Examples of the type of the composition are: 1) Type of the composition diluted with water i) Water-soluble concentrate (SL, LS) 1 part by weight of the compound T of the present invention is dissolved in 9 parts by weight of water or a water-soluble solvent. Alternatively, add a wetting agent or other adjuvant. Once diluted with water, the active substance dissolves. In this way, a composition having an active substance content of 1% by weight was obtained. Ii) Dispersible Concentrate (DC) 20 parts by weight of the compound of the present invention is dissolved in 7 parts by weight of cyclohexanone while (4) parts of a dispersing agent such as polyethylene D ratio is added. Dilute with water to produce a dispersion. The active substance content was 2% by weight. Emulsifying Concentrate (EC) 15 parts by weight of the compound j of the present invention is dissolved in 75 parts by weight of xylene, and calcium dodecylbenzenesulfonate and eucalyptus ethoxylate are added (reset 5 respectively) hurt). Dilution with water to produce an emulsion. The composition has a 15% by weight activity [S1 149026.doc • 144·201103429). Lv) Emulsion (EW 'E〇, ES) 25 parts by weight of the compound I of the invention is dissolved in 35 parts by weight of xylene, while adding calcium dodecylbenzenesulfonate and castor oil ethoxylate (5 stalks respectively) Share). This mixture was introduced into 3 parts by weight of water by means of an emulsifier (Uhraturax) and made into a homogeneous emulsion. Dilute with water to produce an emulsion. The composition has an active substance content of 25% by weight. v) Suspensions (SC, OD, FS) In a searchable ball mill '20 parts by weight of compound I of the invention, while adding 10 parts by weight of dispersant and wetting agent and 7 parts by weight of water or organic solvent' A fine active substance suspension β is obtained which is diluted with water to produce a stable suspension of the active substance. The active substance content of the composition is 2 〇 weight 0 / 〇. V1) Water-dispersible granules and water-soluble granules (WG, SG) 50 parts by weight of the compound I of the invention are finely ground while adding 50 parts by weight of a dispersing agent and a wetting agent, by means of industrial grade equipment (for example, an extruder, a spray tower) , fluidized bed) is prepared as water-dispersible or water-soluble particles. Dilution with water produces a stable dispersion or solution of the active substance. The composition has an active substance content of 50% by weight. Vii) Water-dispersible powder and water-soluble powder (WP, SP, SS, WS) 75 parts by weight of the compound of the present invention were ground in a rotor stator mill while 25 parts by weight of a dispersing agent, a wetting agent and a silicone rubber were added. Dilution with water produces a stable dispersion or solution of the active substance. The active substance content in the composition was 75 wt%. Viii) Gel (GF) 149026.doc -145- 201103429 In an actuated ball mill, 20 parts by weight of the compound of the present invention is impaired, and 1 〇 weight loose &quot;dispersed secret 丨], 〗 〖 舌 八Knife ring y 1 heavy gelling agent wetting agent and 70 parts by weight of water or organic solvent to obtain a fine suspension of the active substance. Dilution with water produces a stable suspension of the active substance to obtain a composition having 20% (w/w) active material. 2. Type of composition to be applied without dilution ix) Powderable powder (DP, DS) 5 parts by weight of the compound j of the present invention was finely ground and intimately mixed with 95 parts by weight of fine powdery kaolin. This operation gave a pulverizable composition having an active substance content of 5% by weight. X) Granules (GR, FG, GG, MG) 5 parts by weight of the compound of the present invention were finely ground and combined with 99 parts by weight of a carrier. Current methods are extrusion, spray drying or fluidized beds. This operation resulted in undiluted granules having an active substance content of 5% by weight. Xi) ULV solution (UL) 10 parts by weight of the compound of the present invention is dissolved in 90 parts by weight of an organic solvent such as diphenylbenzene. This operation gave a composition which was applied without dilution as having an active substance content of 10% by weight. The agrochemical composition typically comprises between 0 and 95% by weight, preferably between 0 and 90% by weight of the active material between the optimum 0.5 and 90% by weight. An active material having a purity of from 90% to 100%, preferably from 95% to 1% by weight (based on the nmr spectrum) is used. Water-soluble concentrates (LS), flowable concentrates (FS), powders for drying treatment, 149026.doc-146-201103429 (DS), for slurry, are usually used for the purpose of treating plant propagation materials, especially seeds. Treated water dispersible powder (ws), water soluble powder (SS), emulsion (ES), emulsifiable concentrate (EC) and gel. These compositions can be applied to plant propagation material, especially seeds, either diluted or undiluted. The relevant composition obtains an active substance concentration of from 0.01 to 60% by weight, preferably from enamel to weight%, in a ready-to-use preparation after 2 to 1 稀释 dilution. Administration can be carried out before or during sowing. Methods of applying agrochemical compounds and compositions thereof to plant propagation materials, particularly seeds, respectively, or treating them are known in the art and include seed dressing, coating, H-soaking, and application along the furrow of the propagation material. method. In a preferred embodiment, the compound or composition thereof is separately applied to the plant propagation material by a method that does not induce germination (for example, by seed dressing, pelletization, coating, and dusting). In a preferred embodiment, a suspension type (FS) composition is used for seed treatment. Typically, the FS composition may comprise U00 g/丨 active material, g&quot; surfactant, 〇 to 200 §/1 prevention; east agent, 0 to 400 g/丨 binder, 〇8 to 20 〇g/i pigment and More than 1 liter of solvent (preferably water). The active substance can be used as it is or in the form of its composition by means of spraying, atomizing, dusting, spreading, brushing, dipping or pouring, for example, directly squirting a solution, a powder, a liquid, a dispersion , emulsion, oily dispersion, paste, powderable product, material for dispersion or granules = application form depends entirely on the intended purpose; it is desirable to ensure that the active substance that is not invented is as Fine distribution. Aqueous application forms can be prepared from emulsion concentrates, pastes or wettable powders (sprayable powders, oily dispersions) by the addition of water. Prepare milk for 149026.doc •147· 201103429 Liquid, paste or oily dispersion, which can be dissolved in oil or solvent by means of a wetting agent, tackifier, sub-agent or emulsifier. Homogenized in water. Alternatively, it is possible to prepare a concentrate consisting of an active substance, a wetting agent, a tackifier, a powder or an emulsifier and, if appropriate, a solvent or oil, and such concentrates are suitable for dilution with water. The concentration of the active substance in the ready-to-use preparation can vary over a relatively wide range. In general, the concentration ranges from 0.0001 to 10% by weight, preferably from 〇1 to summer by weight. It is also possible to successfully use the active substance by the ultra low volume method (ULV), it is possible to apply a composition comprising more than 95% by weight of the active substance, or even to apply the active substance without additives. When used for plant protection, depending on the type of action required, the amount of biomass applied is 0.001 to 2 kg / kg (ha / ha), preferably 〇〇〇 5 to kg / ha Item, better 0.05 to 0.9 kg / public, especially 〇 1 to 〇 75 kg / public. When the plant propagation material (such as a seed) is treated, for example, by dusting, coating or soaking the seed, the active mass generally needs to be in the range of 〇1 to 1000 grams, preferably 1 to 1000 grams, more preferably 1 to 1 gram and preferably 5 to 1 gram per 100 kg of plant propagation material (preferably seed). When used to protect materials or store products, the quality of the active applied is determined by the type of field and the desired effect. The amount conventionally used in material protection is, for example, from 0.001 g to 2 kg, preferably from 0.005 g to i kg of active material per cubic meter of treated material. Various types of oils, wetting agents, adjuvants, herbicides, bactericidal agents, 149026.doc • 148.201103429 agents, other fungicides and/or insecticides may be added to the active substance or compositions thereof Medium, (if appropriate) is added until the time of use (in-tank mixing). These agents may be combined with the compositions of the present invention in a weight ratio of from 1:100 to 100:1, preferably from 1:10 to 10:1. Adjuvants which may be used are especially modified organic polyoxyalkylenes such as Break Thru S 240®; alcohol alkoxylates such as Atplus 245®, Atplus MBA 1303®, Plurafac LF 300® and Lutensol ON 30®; EO/ PO block polymers, for example, Pluronic RPE 203 5® and Genapol B®; alcohol ethoxylates such as Lutensol XP 80®; and sodium dioctylsulfosuccinate such as Leophen RA®. The compositions of the invention in the form of fungicides may also be provided together with other active substances, such as herbicides, insecticides, growth regulators, fungicides or fertilizers, as premixes or, if appropriate, until ready for use. Only mix (mixed in the tank). Mixing Compounds I, II and/or IV in the form of a fungicide or a composition comprising the same with other fungicides results in a number of situations: the fungicidal spectrum of activity expands or prevents fungicides Resistance development. In addition, in many cases, synergies are obtained. The following list of actives that can be used in combination with the compounds of the present invention is intended to illustrate possible combinations, but is not intended to be limiting: A) strobilurin, azoxystrobin, dimoxystrobin , enestroburin, fluoxastrobin, kresoxim-methyl, metominostrobin, 149026.doc -149- 201103429 RESSOstrobin ,. Picoxystrobin, pyraclostrobin, pyripencarb, trifloxystrobin, 2-(2-(6-(3-)-2-mercapto-phenoxy 5-)fluoro-pyrimidin-4-yloxy)-phenyl)-2-oxooxyimido-N-indenyl-acetamide, 3-decyloxy-2-(2-( N-(4-methoxy-phenyl)-cyclopropane-mercaptoimidothioindolyl)-phenyl)-decyl acrylate, (2-a-5-[ 1-(3-methyl) Benzyloxyimido)ethyl]benzyl)carbazate and 2-(2-(3-(2,6-diphenyl)-1-methyl-allylamino) (Alkyl)-phenyl)-2-methoxyimino-N-indenyl-ethinylamine; B) Carboxylamamines - sulfonamides: benylaxyl, benzathine M (benalaxyl-M), benodanil, bixafen, boscalid, carboxin, nail. Fenfuram, fenhexamid, flutolanil, furametpyr, isopyrazam, isotianil, kiralaxyl ), mepronil, metalaxyl, methaul-M (mefenoxam), ofurace, oxadixyl, oxidized rust Oxycarboxin), ° compared to "penthiopyrad", sedaxane, tecloftalam, thifluzamide, tiadinil, 2-amino-4-methyl °°坐-5-aniline, 2-gas-N-(l,l,3-tridecyl-indan-4-yl)-nicotinamide, Ν-(3,,4·,5 ,-Trifluorobiphenyl-2-yl)-3-difluoroindol-1-yl-1H-pyrazole-4-carboxamide, Ν-(4·-trifluorodecylthiobiphenyl- 2-yl)-3-difluorom 149026.doc -150- 201103429 Methyl-1-methyl-1H-pyrazole-4-nonylamine, N-(2-(l,3-didecyl)- Butyl)-phenyl)-1,3-dimercapto-5-fluoro-1H-pyrazole-4-nonylamine and Ν-ρ-ί 1 ' 3 , 3 -dimethyl-butyl) - Phenyl) _ 1 , 3 -dimethyl-5-milk-1H-0 ratio. Sodium methionine; kimenline: dimethomorph, flumorph, pyrim〇rph; 'benzoic acid enriched amine: flumethamine ( Flumetover), It ° fluopicolide, fluopyram, zoxamide, N-(3-ethyl-3,5,5-tridecyl-cyclohexyl)- 3-mercaptoamino-2-hydroxy-benzoguanamine; other slowing amines: carpropamid, dicyclomet, mandiproamid, oxytetracyclin ), silthiofarm and N-(6-decyloxy-pyridin-3-yl)cyclopropanecarboxylic acid decylamine; C) «»Sit-like - triazoles: azaconazole, ratio Bitertanol, &gt;bromuconazole, ring grams. Sitting (cyproconazole), benzene 曱 曱 ring 0 sitting (difenoconazole), 二石肖康0 sitting (diniconazole), 二石肖康 ° sitting-Μ, epoxiconazole, fenbukon. Sitting (fenbuconazole), qikuikun u sitting (fluquinc.onazole), fluorite eve. Flusilazole, flutriafol, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, Ixazole (oxpoconazole), paclobutrazole, Pan Kang sal 149026.doc 151 - 201103429 (penconazole), propiconazole, propionazole, prothioconazole, simeconazole , tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, 1-(4-gas-benzene Base)-2-([1,2,4]triazol-1-yl)-cycloheptanol; -°m° sitting class: cyazofamid, imazalil, rice vinegar ( Pefurazoate), prochloraz, triflumizole; benzopyrene 0 sitting class: benomyl (benomyl), phenendazim (carbendazim), wheat ear (fuberidazole), ° benzene. Sitting (thiabendazole); - Others: ethaboxam, etridiazole, hymexazole, and 2-(4-gas-phenyl)-N-[4-(3, 4-Dimethoxy-phenyl)-isoxazole-5-yl]-2-prop-2-ynyloxy-acetamide; D) Heterocyclic compound-. Specific to 0: fluazinam, pyrifenox, 3-[5-(4-a-phenyl)-2,3-dimethyl-isoxazodin-3-yl] -pyridine, 3-[5-(4-methyl-phenyl)-2,3-dimethylisoxazol-3-yl]-pyridine, 2,3,5,6-tetra-gas- 4-methanesulfonyl-. Bisidine, 3,4,5-trichloropyridine-2,6-mono-carbonitrile, N-(1-(5- desert-3-gas-.pyr.din-2-yl)-ethyl)- 2,4-di-nicotinine decylamine, N-[(5-bromo-3-chloro-η-pyridin-2-yl)-indenyl]-2,4-di-gas - prodecylamine; - pyrimidine . Classification: bupirimate, cyprodinil, diflumetorim, fenarimol, 0 bacterium

[SI 149026.doc • 152· 201103429 (ferimzone), mepanipyrim (mepanipyrim), gas. Set (nitrapyrin), fluorobenzene ° dense. Nuarimol, pyrimethanil; - pilazines: triforine; -° ratio π: seed dressing B (fenpiclonil), deficiency (fludioxonil); Dripping: aldimorph, dodemorph, acetaminophen, fenpropimorph, tridemorph; - sigma: fenpropidin; - Dicarboxylic acid imine: fluoroimid, iprodione, procymidone, vinclozolin; - non-aromatic 5-membered heterocycle: ° oxacillin ( Famoxadone), σ米》fenamidone, flutianil, octhilinone, probenazole, 5-amino-2-isopropyl-3- Side oxy-4-o-indolephenyl-2,3-dihydro-pyrazole-1-thiocarboxylic acid S-allyl ester; - Other: acidified benzox. -S-曱酉-(Acibenzolar-S-methyl), σ π 坐 坐 坐 坐 ami ami ami ami ami ami ami 、 、 、 、 、 ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani ani Captafol), captan, chinomethionat, dazomet, debacarb, diclomezine, difenzoquat, benzophenone-methyl Sulfate, fenoxanil, Folpet, oxolinic acid, piperalin, proquinazid, pyroquilon, veolifen (quinoxyfen), °mα sitting 嗓 026 026 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓 嗓-Chloro-l-(4,6-dimethoxy-mouth-2-yl)-2-mercapto-1H-benzimidazole, 5-gas-7-(4-anthracen brigade. ·)) 6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[l,5-a]pyrimidine and 5-ethyl-6-octyl-[1, 2,4]triazolo[l,5-a]pyrimidin-7-ylamine; E) urethane-thioamino phthalate and dithioamino phthalate, thiram (ferbam) ), Daisen’s words Mancozeb), maneb, manam, metasulphocarb, metiram, propineb, thiram, zineb , ziram (ziram); - amino citrate oxime: benzene 0 sali (benthiavalicarb), methimcarb (diethofencarb), iprolim (iprovalicarb), propamocarb (propamocarb), propamocarb hydrochloride Salt, valiphenal and N-(l-(1-(4-cyano-phenyl)ethenyl)-butan-2-yl) decanoic acid-(4-fluorophenyl) Ester; F) Other active substances - terpenoids: hydrazine, dodine, toxin free base, guazatine, bismuthinoic acid acetate, iminoctadine, gram heat triacetate , 克热净 (alkylbenzene sulfonate); - antibiotics: kasugamycin, kasugamycin hydrochloride, streptomycin, polyoxin (P〇ly〇xine), effective Validamycin A; • Nitrophenyl derivative: binapacryl, large dislocation

[SI 149026.doc -154- 201103429 (dinobuton), white powder (dinocap), nitrthal-isopropyl, tetrachloronitrobenzene (tecnazen); organometallic compounds: fentin salts (fentin salts), Such as triphenyltin sulphate, triphenyltin or fentin hydroxide; - sulfur-containing heterocyclic compounds: dithianon, isoprothiolane; - organic compound: granules Edifenphos), foetyl, fosetyl-aluminum, iprobenfos, eutectic acid and its salts, pyrazophos, tolclofos-methyl ); - organochlorine compounds: chlorothalonil, dichlofluanid, dichlorophen, flusulfamide, hexaesene, pencycuron, five gas and its Salt, phthalide, quintozene, thiophanate-methyl, tolylfluanid, N-(4- gas-2-stone Schottyl-phenyl)- N-ethyl-4-methyl-benzenesulfonamide; - Inorganic active substance: Bordeaux mixture (Bordeaux mix (ture), copper acetate, copper hydroxide, copper oxide, basic copper sulfate, sulfur; - other: biphenyl, indomethacin (br ο η ο ρ ο 1), ° cyflufenamid, cream urea Cyanoxanil, diphenylamine, metrafenone, mildiomycin, carbendazim copper (〇乂111-.〇卩卩61&gt;), cyclohexanoic acid|bow (卩1 *〇116乂3(^01^-.31(^11111), spiroxamine, tolylfluanid, N-149026.doc -155 - 201103429 (cyclopropylmethoxy) Amino-(6-difluoro-methoxy-2,3-difluoro-phenyl)-indenyl-2-propenylamine, ν'-(4-(4-gas-3-di Gasoyl-phenoxy)-2,5-dimercapto-phenylethyl-N-mercaptopurine, N'-(4-(4-]-3-trifluoromethylphenoxy _2,5-didecyl-phenylethyl-N-indenyl hydrazine, N,-(2-methyl-5-trifluoromethyl-4-(3-trimethyldecyl-propyloxy) -Phenyl)-N-ethyl-N-methylformamidine, N,-(5-difluoromethyl-2-indolyl-4-(3-tridecylfluorenyl-propoxy) -Phenyl)-N-ethyl-N-methylformamidine, 2-{1-[2-(5•indolyl-3-trifluoromethyl)-. Bisazo-1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-furoate-yl-(1,2,3,4-tetrahydro-naphthalen-1-yl)-indole Amine, 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-carboxylic acid hydrazine --(R)-l,2,3,4-tetrahydro-naphthalen-1-yl-decylamine, 6-tert-butyl-8-fluoro-2,3-dimercapto-quinoline-4 - Alkyl ester and decyloxy-acetic acid 6-tert-butyl-8-fluoro-2,3-dimercapto-quinolin-4-yl. G) Growth regulator Abscisic acid. Amidochlor, ancymidol, 6-benzylaminopurine, brassinolide, butralin, chlormequat (chlormequat) (chlormequat chloride)), choline chloride, cyclanilide, daminozide, dikegulac. Dimethipin, 2,6-dimercapto 0 bite, ethephon, lL flumetralin, flurprimidol, fluthiacet, gas ° Forchlorfenuron, gibberellic acid [S1 149026.doc 156- 201103429 (gibberellic acid), inabenfide,. lead. _3-acetic acid, maleic hydrazide, mefluidide, mepiquat (strong cotton), naphthaleneacetic acid, N-6-benzyl gland嘌吟, bucksin, cyclized acid (about cyclic acid), propyl jasmonate (prohydrojasmon), thidiazuron, triapenthenol, tributyl trithiophosphate, 2, 3, 5-triterpene benzoic acid, trinexapac-ethyl and thin effect. H) Herbicide - Acetamamine: acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, Flufenacet, mefenacet, metolachlor, metazachlor, napropamide, naproanilide, enegrass Pethoxamid, pretilachlor, propachlor, thenylchlor; - amino acid derivatives: bianafos, glyphosate, sessile (glufosinate), sulfosate; - aryloxyphenoxypropionates: clodinafop, cyhalofop-butyl, °° fenoxaprop , 0 fluazifop, ° haloxyfop, ° β 醯 胺 met met (metamifop), propaquizafop, qui 灵 灵 (quizalofop), 喧 糠 糠Vinegar (quizalofop-P-tefuryl); 149026.doc -157- 201103429 联° ratio α categorization. Diquat, herb (paraquat); -(thio)carbamates: asulam, butarate, carbeamide, desmedipham, dimepiperate, flutter Herbicide (eptam, EPTC), esprocarb, m〇iinate, orbencarb, phenmedipham, prosulfocarb, pyributicarb , thiobencarb, triallate; &quot; cycloheximide: butroxydim, clethodim, cyci〇xydim, benzophenone (profoxydim), sethoxydim, tepraloxydim, tralkoxydim; -mononitroaniline: benfluralin, etalfluralin, safety Ling (〇ryzalin), pendimethalin, amine prodiamine, trifluralin; - benzene mystery: three it acifluorfen, benzene grass scale (aclonifen ), bifenox, diclofop, ethoxyfen, flufenacetate (fomeSafen) ), lactofen, oxyfluorfen; - benzoquinones: bomoxynil, dichlobenil, benzonitrile; &quot; 0 m 0 sitny ketones: imazamethabenz, imazamox, imidazonic acid (imazapic), imaza_ Pyr, imazaquin, σ米草于(imazethapyr); 149026.doc •158- 201103429 - Phenoxyacetic acid: clomeprop, 2,4-dioxyacetic acid (2,4-D), 2,4-DB, Dichlorprop, MCPA, MCPA-thioethyl, MCPB, 2-methyl-4-chloropropionic acid (Mecoprop); -° ratio ° Qin: chloridazon, flurazepam Flufenpyr-ethyl), fluthiacet, norflurazon, pyridate; -beta ratio: chloramine D than aminopyralid, clopyralid ), ° diflufenican, dithiopyr, fluridone, fluroxy-pyr, picloram, fluoride. Picolinfen, &lt;thiazopyr; - continuation of urea: ami 密 密 续 ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami ami Bensulfuron, chlorimuron-ethyl, chloi'sulfuron, cinosulfuron, cyclosulfamuron, ethoxy sulfonate Ethoxysulfuron), flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, chlorine. Halosulfuron, 〇 0 0-0 0^, iazosulfuron, iodosulfuron, mesosulfuron, metsulfuron-methyl, . Nicosulfuron, oxasulfuron, fluorine. Primisulfuron, prosulfuron, ° ratio, pyrazosulfuron, rimsulfuron, sulfometuron, canning 149026.doc - 159-201103429 (sulfosulfuron), thifensulfuron, triasulfuron, tribenuron, trifloxysulfuron, triflusulfuron, trifluorosulfon Tritosulfuron, 1-((2-gas-6-propyl-flavored[1,2-b]pyridazin-3-yl)sulfonyl)-3-(4,6- Dimethoxy-pyrimidin-2-yl)urea; - triterpenoids: ametryn, atrazine, cyanazine, dimethametryn, gamma Ketone (ethiozin), hexazinone, metami-tron, metribuzin, prometryn, simazine, terbuthylazine ), terbutryn, triaziflam; -urea: chlorotoluron 'daimuron, diuron, fluometuron ), isoproturon, linuron, methabenz-thiazuron, tebuthiuron; - other acetamidine lactate synthase inhibitor: bispyribac-sodium ( Bispyribac-sodium), cloransulam-methyl, diclosulam, florasulam, flucarbazone, beta Flumetsulam, metasulam, ortho-sulfamuron, penoxsulam, propoxycarbazone, propyl vinegar (pyribambenz- Propylbenzoxim, pyrifalid, pyrimiminobac-methyl, pyrimisulfan, pyrithiobac,

[SI 149026.doc -160- 201103429 Pyroxasulfone, pyrocycline (pyroxsulam); Other: Amine. Take amicarbazone and amine III. Sit, anilofos, beflubutamid, ben-azolin, bencarbazone, benflu-resate, bisflurone Benzofenap), bentazone, benzobicyclon, bromacil, bromobutide, butafenacil, butamifos, Cafenstrole, ° sitting brewing | Carfentrazone, cinidon-ethlyl, chlorthal, cinmethylin, can be eliminated ( Clomazone), cumyluron, °cyprosulfamide, dicamba, difenzoquat, diflufenzopyr, Helicobacter sphaeroides )rec/^/era monoceras), grass 0 more endothal, ethofumesate, etobenzanid, fentrazamide, amylamine Flumiclorac-pentyl, flumioxazin, flubenzol, fluchaxam, flurochl Oridone), flurtamone, indanofan, isoxaben, isoxaflutole, lenacil, propanil, pent Propyzamide, quinclorac, quinmerac, mesotrione, decyl decanoic acid, naptalam, propane oxacillin (oxadiargyl), oxadiazon, oxazinone 149026.doc -161 - 201103429 (oxaziclomefone), pentoxazone, pinoxaden, oxazolidine (pyraclonil), pyraflufen-ethyl, pyraflufen-ethyl. More than tori (pyrasulfotole), pyrazoxyfen, yala. Pyrazolynate, quinocal, sulcotrione, sulfentrazone, terbacil, tefuryltrione ), tembotrione, °thiencarbazone, topramezone, 4-hydroxy-3-[2-(2-decyloxy-ethoxyindolyl)_ 6-trifluoromethylpyridin-3-carbonyl]-bicyclo[3.2.1]oct-3-en-2-one, (3-[2- gas-4-fluoro-5-(3-indolyl)- 2,6-di-oxy-4-dioxamethyl-3,6-diaza-2Η-σ-[beta]-1-yl)-indolyl]pyredo-2-yloxy)-acetic acid乙酉,6-Amino-5-Ga-2 -ί哀propyl- °3⁄4°定-4-carboxylic acid vinegar, 6-gas-3_(2-cyclopropyl-6-methyl-phenoxy )-pyridazin-4-ol, 4-amino-3-gas-6-(4-a-phenyl)-5.fluoro-pyridine-2-carboxylic acid, 4-amino-3-gas-6- (4-Ga-2·Fluoro-3-indolyl-phenyl)-pyridin-2-indole decyl ester and 4-amino-3-chloro-6-(4- gas-3-dimethylamine Ethyl-2-fluoro-phenyl)-pyridine-2-decanoate. I) Insecticides - Organic (thio) acid salts: acephate, azamethiphos, azinphos-methyl, chlorpyrifos, strontium Chlorpyrifos-methyl, chlorfenvinphos, dizinon, dichlorvos, dicrotophos, dimethoate, disulfoton , ethion, sputum-162- 149026.doc 201103429 (fenitrothion), fenthion, isoxathion, malathion, methamidophos, methadinion ), methyl-parathion, mevinphos, monocrotophos, oxydemeton-methyl &gt; paraoxon, parathion , phenthoate, phosalone, phosmet, phosphamidon, phorate, phoxim, pirimiphos-methyl , profenofos, prothiofos ), sulprophos, tetrachlorvinphos, terbufos, triazophos, trichlorfon; - urethane for the purpose: alanycarb , aldicarb, bendiocarb 'benfuracarb, carbaryl, carbofuran, carbosulfan, fenoxycarb , furathiocarb, metiocarb, methodyl, oxamyl, pirimicarb, propoxur, thiodicarb, ° Sitting on triazamate; - pyrethroid: acryl pyrethrum (allethrin) bifenthrin, cyfluthrin, cyhalothrin, cyphenothrin, race Nyper (cypermethrin), α-saidingin, β-saidingin, zeta-cypermethrin, deltamethrin, esfenvalerate 'etofenprox, fen Puning 149026.doc -163- 201103429 (fenpropathrin) &gt; Fenvalerate, Epnin ( Imiprothrin), lambda cyhal〇thrin, permethrin, praUethrin, pyrethrin I and II, resmethHn, fluoroquinone Silamfluofen, tau_fiuvaiinate, tefluthrin, tetramethrin, tralmethrin, transfiuthrin, propyl i chrysanthemum (profluthrin), PTFE, dimethfluthrin; - insect growth regulator: a) chitin synthesis inhibitor: benzoylureas, chifu rfiuazuron, race Cyramazin - diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, defolon Teflubenzuron), triflumuron; buprofezin, diofenolan, hexythiazox, etoxazole, clofentazine; b) ecdysone antagonism Agent: hafenofozide, methoxyfenozide, defenof Tebufenozide), azadirachtin; c) juvenile hormone analogues: pyriproxyfen, metopor, fenolect; d) lipid biosynthesis inhibitors: Spirodiclofen), spiromesifen, spirotetramat; - nicotinic receptor agonist/antagonist compound: cotinine 149026.doc 201103429 (clothianidin), bituminamine (dinotefuran) ), imidacloprid, thiamethoxam, nitenpyram, acetamiprid, thiacloprid, 1- (2-Chlorosine- 5-ylmethyl)-2-stone succinimido-3,5-diindolyl-[1,3,5]triazine; -GABA antagonist compound: endosulfan, ethiprole , fipronil, vaniliprole, pyrafluprole, pyriprole, 5-amino-1-(2,6-dichloro-4-methyl-benzene Base 4-aminosulfinyl-1H-pyrazole-3-thiodecanoic acid decylamine; - macrocyclic vinegar insecticide: aba; adam (abamectin), emtermectin (ememectin), dense Miltmectin Lepimectin, spinosad, spinetoram; - mitochondrial electron transport inhibitor (METI) I acaricide: fenazaquin, pyridaben, Tebufenpyrad, tolfenpyrad, flufenerim; -METI II and III compounds: acequinocyl, fluacyprim, hydramethylnon ; - Uncoupling agent: chlorfenapyr; - oxidative phosphorylation inhibitors: cyhexatin, diafenthiuron, fenbutatin oxide, propargite; 149026.doc -165- 201103429 - Fracturing agent compound. Cryomazine; - Mixed functional oxidation inhibitor: piperonyl butoxide &gt; - Sodium channel blocker. Indoxacarb ( Indoxacarb), metaflumizone ί - other · Benkeeze (benclothiaz), bifenazate, catapap, dr〇nicamid, ° (pyridalyl), pymetrozine ' thio, thiocyclam, blessing Flubendiamide, chitrantraniliprole, cyanidin receptor (cyazypyr, HGW86), cyenopyrafen, cyenopyrafen. Compared with I, fiupyrazofos, 0 cyflumetofen, amid 〇 fiumet 'imicyafos, bistrifluron and bistrifluron. Pyrifluquinazon ° The present invention further relates to an agrochemical composition comprising at least one compound I, II and/or IV (component hydrazine) and at least one other active substance suitable for plant protection (for example, Selected from Groups A) to 1)) (Component 2), especially another fungicide such as one or more fungicides from Groups A) to F) as described above, and, if desired, a suitable A mixture of solvents or solid carriers. Particular attention is paid to their mixtures' because at the same application rate, many of them exhibit a higher efficacy against harmful fungi. Furthermore, the mixture of the fungicides of the compounds I, II and/or IV and at least _ from the group A as described above against the harmful fungi is compared to the individual compounds I, II or IV or from the groups A) to F) Individual fungicides are more effective against their fungi. By administering the compound IS ] 149026.doc -166- 201103429 I, II and/or IV together with at least one active substance from groups A) to :), a synergistic effect can be obtained, ie not only individual effects are obtained Simple addition (collaboration mixture). According to the invention, the administration of the compound t or ^ together with at least one other active substance is understood to mean that at least one compound of the formula I, II and/or IV and at least one further active substance occur simultaneously at the point of action in the true-acting amount (also That is, harmful fungi or their habitats, such as susceptible plants, plant propagation materials (especially seeds), surfaces, materials or soil, and plants, plant propagation materials (especially seeds) that are protected from fungal attack, Soil, surface, material or room). This can be done by simultaneous (in combination (for example in the form of a mixed formulation in the tank) or separately) or by continuous application of the compound, 11 and/or 1, and at least another active substance, the time between individual administrations The interval is selected to ensure that the active substance applied first is still present at the point of action when the other active substance is applied, and the order of application is not critical to the practice of the invention. Mixed in the yuan. (i.e., a composition of the invention comprising a compound I, II or IV (component 1) and another active substance (component 2) (e.g., active from group VIII (4))) _ component! The weight ratio to component 2 generally depends on the nature of the active substance used, usually in the range of 1:100 to 100:1, often in the range of 1.50 to 50:1, preferably 1:2 to 2 More preferably, the range of 〇1 is in the range of 1:10 to 1 (): 1 and especially in the range of i(1)]. In the diterpene mixture (ie containing one compound 1 (component 1) and the first other active substance (component 2) and the: other active substance f (component paste, eg from group A) to the two activities of hydrazine In the composition of the invention), the weight ratio of component i to the group 149026.doc-167-201103429 part 2 depends on the nature of the active substance used, preferably in the range of 〇:5〇 to 50:1. And especially in the range of 1:10 to 10:1, and the weight of component 1 and component 3 is preferably in the range of 1:50 to 5〇:1 and especially in the range of 1:1〇 to 1 〇: 1 Within the scope. The components may be used individually or partially or completely mixed with each other to prepare the compositions of the present invention. It may also be additionally packaged as a combination composition (such as a kit of dispensing parts) and used. In one embodiment of the invention, the kit may include one or more (including all) components useful for preparing the agrochemical compositions of the present invention. For example, the kit may include one or more fungicide components and/or adjuvant components and/or insecticide components and/or growth regulator components and/or herbicides. One or more components may have been combined or pre-provisioned. In embodiments in which more than two components are provided in a kit, the components may be combined together and packaged in a single container (such as a vial, bottle, can, + bag, bag or can). In other embodiments, two or more sets of injuries may be packaged separately, i.e., no pre-distribution is performed. Thus, the kit can include one or more separate containers 'such as vial' cans, bottles, sachets, bags or cans, each containing a separate component of the agrochemical composition. In both forms, the components of the kit may be administered separately from the other components or together with the other components or as a component of the combination composition of the invention for use in preparing the compositions of the invention. The user typically applies the compositions of the present invention from a pre-dosing device, a knapsack sprayer, a spray tank or a spray aircraft. Here, the agrochemical composition is supplemented with water and/or a buffer to a desired application concentration, and if appropriate, I49026.doc-168-201103429 may be added, thereby obtaining the gp field of the present invention - month &lt; ready-to-use spray or agrochemical composition. Typically, 50 to 500 liters of ready-to-use spray fluid, preferably 100 to 400 liters, is applied per hectare of agriculturally effective surface and beta hyperbolic. According to an embodiment, the individual components of the composition (such as parts of a kit or portions of a binary or ternary mixture) may be mixed by the user himself in a spray tank and, if appropriate, other auxiliaries may be added. (mixed in the tank). In another embodiment, the individual components or portions of the pre-mixed components of the compositions of the present invention (eg, comprising Compounds 'II and/or IV and/or from Group 8) may be mixed by the user in a spray tank. 1} component of the active substance) and (if appropriate) other additives and additives (in-tank mixing) may be added. In another embodiment, the individual components or portions of the pre-mixed components of the compositions of the invention may be combined (eg, after mixing in a tank) or continuously (eg, comprising Compounds I, II, and/or IV and/or The components of the active substances from the group gossip to !)). Preference is also given to the inclusion of compounds I, II and/or IV (component 1) and at least one of the estrogens (component 2) selected from group A) and in particular from atoximin, toxix, A mixture of active substances of fluoxetamine, kexinxin, oryzanidin, oxymyrazine, pyraclostrobin and sulphate. Also preferably, it comprises a compound I, II and/or IV (component 1) and at least one carboxamide selected from the group B) (component 2) and is especially selected from the group consisting of fennel, bokley, sender, Cyclosporine, chlorhexidine, iso-sigzazin, metalaxyl, guanamine, daxen, flumorph, fluopyramine (picmidine), chloramphenicol, gupamine, Mandipropamid and Ν-(3,,4',5'-trifluorobiphenyl-2-yl)-3-difluorodecyl-1-methyl-1Η-pyrazole_4_ Mixture of active substances of methopea 149026.doc • 169· 201103429. Preferably, it comprises a compound of the formula 1, 11 and/or 1v (component 1) and at least one group (component 2) and is especially selected from the group consisting of cyclosporine, difenophene, spiroxazole, fluorine. Queconazole, fluoxazole, dimethoate, meconazole, dexamethasone, propiconazole, propylthioglycol, trimethoate, three tailong, dexke, cyclamate, poker A mixture of active substances of pull, racen, benzon, befenfen and ethipramine. Also preferably, it comprises a compound I, π and/or IV (component 1) and at least one heterocyclic compound selected from group D) (component 2) and is especially selected from the group consisting of chlorhexidine, simboldine and fenremore. ,Mippanicin, Billy Methani, Saifunin, Tiemar, Mamulin, Fen Tinglin, Tridemorpholine, Benzidine, Epto, Ethyl, Oxazone, Imidazole Ketone, thiabendazole, puquinaz, acidified stupid and thiadiazole-s-methyl ester, tetradone, fore, phlorin, vebufen and 5_ethyl-6-octyl-[ A mixture of 1,2,4]triazolo[u-a]pyrimidine-7-ylamine actives. It is also preferred to comprise the compound j, π and/or 1 ¥ (component 丨) and at least one amine decanoate selected from the group E) (component 2) and especially selected from the group consisting of mancozeb and desen , a mixture of active substances of zinc, zinc, thiram, carbendazim, phenthiali and propamocarb. Also preferably, it comprises a compound I, hydrazine and/or IV (component 1) and at least one fungicide (component 2) selected from the group F) and is especially selected from the group consisting of nitrile sulfonium and tribasic tin salts. (such as triphenyl vinegar) 'triethyl sulphate, triethylphosphonic acid ing, H3Pq3 &amp; its salt, chlorothalonil, Yifaling, thiopurine, copper acetate, copper hydride, copper oxychloride, sulfuric acid Copper, sulfur, cymoxanil, metribenol and spirobacteria 149026.doc -170· 201103429 A mixture of active substances of amines. Accordingly, the present invention is further directed to a composition comprising Compound I, hydrazine and/or IV (Component 1) and another active negative (Component 2) 'The other active substance is selected from Table B B-1 Go to the "Component 2" line in column B-3. Another embodiment relates to the compositions B _ 1 to b _ 3 4 6 listed in Table B, wherein one of the tables B is in each case corresponding to a compound comprising an individualized formula I, II or IV of the present specification (French 1) and the fungicidal compositions of the respective other active substances (component 2) from groups A) to I) as described in the relevant columns. Preferably, the composition comprises a synergistically effective amount of active material. Table B: Composition mixture comprising an individual compound I, hydrazine or IV and another active substance from groups A) to I) Component 1 Component 2 B-1 An individualized compound I, II or IV敏'-- B-2 an individualized compound I, II or IV - simianid--B-3 an individualized compound I, II or IV enestrobin B-4 an individualized compound I, II or IV fluoxetine B-5 an individualized compound I, II or IV 克收欣~~- B-6 an individualized compound I, II or IV phenoxybamine 'B-7 an individualized compound I, II Or IV orystatin-- B-8 an individualized compound I, II or IV-hyperoxybamine--- B-9 an individualized compound I, II or IV 100-sensitive - B-10 an individualized compound I , II or IV pyrabenyl _-- B-11 an individualized compound 1, U or IV trifluoro-sensitive ~ '--~~~ B-12 an individualized compound I, II or IV 2-(2- (6-(3-Gas-2-pyroxyl-phenylpyrimidin-4-yloxy)-phenyl)-2-indolyloxyimido-N-methyl-acetamide B-13 Compound I, hydrazine or IV 2-(o-((2,5-indolyl)-oxymethylene)phenyl)-3-decyloxy- Acrylate methyl ester B-14 An individualized compound I, hydrazine or IV 3-decyloxy-2-(2-(N-(4-decyloxy-phenyl)-cyclopropanimide) Alkylthiomethyl)·Acrylic Acid·Acrylic Acid Vinegar 149026.doc -171 - 201103429 Mixture Component 1 Component 2 B-15 An Individualized Compound I, II or IV 2-(2-(3- (2,6-diphenyl)-1-indolyl-allylaminooxyindolyl)-phenyl)-2-indolyloxyimido-N-methyl-acetamidamine B -16 An individualized compound I, II or IV Benzophene B-17 An individualized compound I, II or IV Benzocycline-M B-18 An individualized compound I, II or IV A wheat rust B-19 Individualized compound I, II or IV fennel B-20 An individualized compound I, II or IV Bokley B-21 an individualized compound I, II or IV oxazepine B-22 an individualized compound I, II or IV furfuramide B-23 an individualized compound I, II or IV cyclosporin B-24 an individualized compound I, II or IV fluentin B-25 an individualized compound I, II or IV An individualized compound of B-27, an individualized compound I, II or IV I, II or IV Isotianil B-28 An individualized compound I, II or IV Carrageen B-29 An individualized compound I, II or IV rust-free amine B-30 An individualized compound I, II or IV达达乐 B-31 An individualized compound I, II or IV statin-M B-32 an individualized compound I, II or IV ocalamine B-33 an individualized compound I, II or IV B-34 An individualized compound I, II or IV oxidized wilting B-35 an individualized compound I, II or IV pirimipenem B-36 an individualized compound I, II or IV 森达先 B-37 An individualized compound I, II or IV gram-depleted B-38 an individualized compound I, II or IV cyprofen B-39 an individualized compound I, II or IV steroidal B-40 an individualized compound I , II or IV 2-Amino-4-mercapto-α-Serb-5-anthracene aniline B-41 An individualized compound I, II or IV 2-gas-N-(l,l,3-dioxin Base-man-4 base)-final amine B-42 an individualized compound I, hydrazine or IV N-(3',4',5L-trifluorobiphenyl-2-yl)-3-difluoromethyl Alkyl-1-mercapto-1H-pyrazole-4-decylamine B-43 an individualized compound I, II IV N-(4L Dimethylsulfonylbiphenyl-2-yl)-3-difluoromethyl-1-indolylpyrazole-4-carboxamide A-II An individualized compound I, II or IV N-(2-(l,3-dimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1H-. ratio. -4-Methylamine B-45 An individualized compound I, II or IV (2-(1,3,3-tridecyl-butyl)-phenyl)-1,3-dimethyl- 5-fluoro-1H-pyrazole-4-carboamine B-46 An individualized compound I, II or IV, earth Λ» Λ#· 达灭分 B-47 an individualized compound I, II or IV fluoride琪琳B-48 An individualized compound I, II or IV butyl 0 ratio B-49 an individualized compound I, hydrazine or IV flumetamide B-50 an individualized compound I, II or IV fluoro 0 ratio Azinamide [si 149026.doc -172- 201103429 Mixture component 1 component 2 B-51 an individualized compound I' II or IV flupirtine B-52 an individualized compound I, II or IV gas benzoguanamine B -53 An individualized compound I, II or IV N-(3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-indolylamino-2-hydroxy-benzamide-5 -54 an individualized compound I, II or IV gupamine B-55 an individualized compound I, II or IV diclocarbam B-56 an individualized compound I, II or IV diacetylidin B-57 An individualized compound I, II or IV oxytetracycline B-58 an individualized compound I, II or IV Sirthiofam B-59 An individualized compound I, II or IV N-(6-methoxy-° ratio -3-yl) cyproterone decanoate B-60 An individualized compound I, II or IV Aza Conazole B-61 an individualized compound I, II or IV than donut B-62 an individualized compound I, II or IV bromoxynazole B-63 an individualized compound I, II or IV cycloheximide B-64 An individualized compound I, II or IV difenoconazole B-65 an individualized compound I, II or IV diconazole B-66 an individual compound I, II or IV dinitron-M B- 67 An individualized compound I, II or IV fluorocyclic guanidine B-68 an individualized compound I, II or IV fenbucarbin B-69 an individualized compound I, II or IV fluquinazole B-70 an individual Compound I, II or IV Fluorocarbazole B-71 An individualized compound I, II or IV Difluben B-72 An individualized compound I, II or IV Liukang Sal B-73 An individualized compound I, II Or IV imidazole B-74 an individualized compound I, II or IV Epproxazole B-75 An individualized compound I, hydrazine or IV fluconazole B-76 An individualized compound I, II or IV B-77 Tennyson individualized one kind of compound I, II or IV ah. Meter. Sit B-78 An individualized compound I, II or IV Bark B-79 An individualized compound I, II or IV Pancon. Sit B-80 An individualized compound I, II or IV. S-B-81 an individualized compound I, II or IV propyl thiol azole B-82 an individualized compound I, II or IV fluorazole B-83 an individualized compound I, II or IV Dekley B-84 An individualized compound I, II or IV fluoroether oxime B-85 an individualized compound I, II or IV ternate B-86 an individualized compound I, II or IV three tylon B-87 an individualized compound I, II or IV ring bacteria. S-B-88 An individualized compound I, II or IV Difficulty sitting B-89 An individualized compound I, II or IV 1 -(4-chloro-phenyl)-2-([ 1,2,4] Triazol-1-yl)-cycloheptanol B-90 An individualized compound I, II or IV #座灭149026.doc •173- 201103429 Mixture component 1 Component 2 B-91 An individualized compound I, Π Or IV according to B-92 an individualized compound I, II or IV thiosulfate B-93 an individualized compound I, II or IV indole ester B-94 an individualized compound I, II or IV Poker Pulling B-95 an individualized compound I, II or IV Safran B-96 an individualized compound I, II or IV benomyl B-97 an individualized compound I, II or IV befenfen B-98 Individualized compound I, II or IV Maishenling B-99 An individualized compound I, II or IV Thiabendazole B-100 An individualized compound I, oxime or IV Thiabamide B-101 An individualized compound I , II or IV eduli B-102 an individualized compound I, II or IV carbendazim B-103 an individualized compound I, II or IV 2-(4-chloro-phenyl)-N-[4- (3,4-dimethoxy-phenyl)恶°坐-5-yl]-2-propan-2-freeoxy-acetamidamine B-104 an individualized compound I, II or IV edugamine B-105 an individualized compound I, II or IV Bifeno B-106 an individualized compound I, II or IV 3-[5-(4-a-phenyl)-2,3-dimethyl-isoxazole quinone-3-yl]-α ratio Bite B-107 An individualized compound I, II or IV 3-[5-(4-methyl-phenyl)-2,3-dimethyl-isoxime sulphate-3-yl]-° ratio. B-108 An individualized compound I, II or IV 2,3,5,6-tetrachloro-4-methylsulfonyl-pyridine B-109 An individualized compound I, II or IV 3,4,5- Triclopyridin-2,6-dicarbonitrile B-110 An individualized compound I, II or IV N-(l-(5_ &gt;odor-3-chloro-π ratio-2-yl)-ethyl -2,4-Dichloro-nicotinium amide B-lll An individualized compound I, II or IV Ν-((5-involved-3-chloro-° ratio ̄-2-yl)-methyl) -2,4-Dichloro-nicotinium amide A-II, an individualized compound I, II or IV, sulfamethoxazole B-113, an individualized compound I, II or IV, Sibodine B-114, an individualized compound I, II or IV diflurine B-115 an individualized compound I, II or IV fenrimyl B-116 an individualized compound I, II or IV azoxystrobin B-117 an individualized compound I, hydrazine or IV Mippanicin B-118 an individualized compound I, II or IV chloropyridine B-119 an individualized compound I, II or IV fluoropyrimidinol B-120 an individualized compound I, II or IV B-121 An individualized compound I, II or IV Safranine B-122 An individualized compound I, II or IV Seed dressing B-123 Alimentation of Compound I, II or IV Refining B-124 An Individualized Compound I, II or IV Adiline B-125 An Individualized Compound I, II or IV. carbendazim B-126 An Individualized Compound I, II or IV carbendazim acetate B-127 an individualized compound I, II or IV powder rust [si 149026.doc •174- 201103429 mixture M part 1 component 2 -- B-128 an individualized compound I, Π Or IV thirteen--- B-129 an individualized compound I, II or IV fenpropidin B-130 an individualized compound I, II or IV messy imine __ B-131 an individualized compound I , Π or IV 依普同---- B-132 an individualized compound I, II or IV fentanyl - B-133 an individualized compound I, II or IV konkening __- B-134 Compound I, II or IV sputum ketone -- B-135 An individualized compound I, hydrazine or IV σ σ 坐 oxycodone B-136 An individualized compound I, II or rv fluentin __- B- 137 An individualized compound I, hydrazine or IV bismuth B-138 An individualized compound I, hydrazine or IV thiabendazole - _ - B-139 an individualized compound I, II or rv 5-Amino-2-iso-propyl-4-o-tolyl-2,j-dihydro-pyrazole-1 -thiocarboxylic acid s-allyl vinegar B-140 An individualized compound I, II or IV Acidified benzothiazepine-s-methyl ester - B-141 An individualized compound I, hydrazine or IV carbazolam bromide B-142 An individualized compound I, II or rv carbendazim __ B-143 An individualized compound I, II or rv blasticidin-S B-144 an individualized compound I, hydrazine or IV ethene B-145 an individualized compound I, hydrazine or IV cappdan B-146 an individual Compound I, Π or IV 螨 螨 B-147 An individualized compound I, Π or IV 迈隆 B-148 An individualized compound I, II or IV imiprozil B-149 an individualized compound I, hydrazine or IV 哒菌清 B-150 An individualized compound I, Π or IV benzophenone fast B-151 An individualized compound I, II or IV methyl acesulfate benzoate B-152 an individualized compound I, π or rv Cao Ling B-153 An individualized compound I, oxime or IV Forbeline B-154 An individualized compound I, oxime or IV Oxolins Sure B-155 An individualized compound I, Π or IV powder disease B- 156 one Individualized compound I, II or IV Puccinaz ~~- B-157 An individualized compound I, hydrazine or IV 百--- B-158 an individualized compound I, II or IV 7 夬norfen' ~ ~~- B-159 - Individualized compound I, II or IV Imidazolium - B-160 An individualized compound I, II or rv Trixazole - B-161 An individualized compound I, hydrazine or IV 2-butenyl · 6-Moth-3-propyl · bite coal B-162 an individualized compound I, hydrazine or IV fluorenyl-1 Η-benzimidazole B-163 an individualized compound I, II or IV 5-gas-7- (4-mercapto-0 bottom bite trifluoro-phenyl (4) training three. Sit and B-164 an individualized compound I, hydrazine or IV 5-ethyl-6·octyl·[〗, 2,4]triazime-7-ylamine [,5'a] B-165 an individual Compound I, hydrazine or IV thiram - B-166 an individualized compound I, hydrazine or IV Mn-Zn-175· 149026.doc 201103429 Mixture component 1 Component 2 B-167 An individualized compound I, II or IV代森猛 B-168 An individualized compound I, II or IV Wei Biao B-169 An individualized compound I, Π or IV 菌菌B-170 An individualized compound I, II or IV 森森联 B- 171 An individualized compound I, II or rv propyl zinc B-172 An individualized compound I, II or IV thiram B-173 An individualized compound I, II or rv Desensen B-174 An individualized compound I , II or IV 福美辞 B-175 an individualized compound I, II or IV. carbendazim B-176 an individualized compound I, II or IV phenothranol' B-177 an individualized compound I, hydrazine or IV缬 威B-178 An individualized compound I, hydrazine or IV acesulfame B-179 An individualized compound I, hydrazine or IV Phytophthora hydrochloride B-180 An individualized Compound I, hydrazine or IV virifene B-181 an individualized compound I, II or IV N-(l-(l-(4-cyanophenyl)ethanesulfonyl)-butan-2-yl) Amino phthalic acid-(4-fluorophenyl) ester B-182 An individualized compound I, II or rv. Tonin B-183 An individualized compound I, hydrazine or IV. Toxin free base B-184 an individual compound I, hydrazine or IV bisindole B-185 an individualized compound I, II or IV bisindole octyl acetate B-186 an individualized compound I, π or rv bis-octylamine B-187 an individualized compound I, II or rv Bis-octylamine triacetate B-188 An individualized compound I, II or IV grams of pyrogen (alkane) B-189 An individualized compound I, II or IV Chunctomycin B-190 Compound I, II or IV Salicin Hydrochloride Salt B-191 An Individualized Compound I, II or IV Polyoxin B-192 An Individualized Compound I, II or IV Streptomycin B-193 An Individual Compound I, II or rv Aminomycin A B-194 An individualized compound I, II or IV Baikeke B-195 An individualized compound I, π or IV Dicloran B-196 Alimentation of compound I, II or rv Large depurination B-197 An individualized compound I, II or IV White powder B-198 An individualized compound I, II or IV Trichostatin B-199 An individualized compound I, II Or rv tetra-nitrobenzene B-200 an individualized compound I, π or rv triphenyltin salt B-201 an individualized compound I, II or IV nitrile sulfonium B-202 an individualized compound I, II or IV Indigo B-203 An individualized compound I, π or rv Pleurotus ostreatus B-204 An individualized compound I, II or rv Triethylphosphonic acid, aluminum triethylphosphonate B-205 An individualized compound I, π Or IV propyl chelsson B-206 an individualized compound I, π or IV phosphoric acid (h3po3) and derivative B-207 an individualized compound I, hydrazine or IV white pine B-208 an individualized compound I, π or Rv 脱克松[si 149026.doc •176- 201103429 Mixture Component 1 Component 2 B-209 An Individualized Compound I, II or IV Chlorothalon B-210 An Individualized Compound I, II or IV Yifaling B -211 An individualized compound I, II or IV Bisphenol - B-212 An individualized compound I, hydrazine or IV fluorosulfur B-213 An individualized compound I, hydrazine or IV hexascreen B-214 An individualized compound I, II or IV Bin-clone ~- B-215 An individualized compound I, hydrazine or IV pentoxide and its salts B-216 An individualized compound I, II or IV phenylhydrazine _ a ~ B-217 an individualized compound I' II or IV quetiacin ~~' --- B-218 an individualized compound I, II or IV Quitopurine B-219 An individualized compound I, II or IV methyl valproate B-220 An individualized compound I, hydrazine or IV Ν-(4-chloro-2-nitro-phenyl)-hydrazine- Ethyl-4-methyl-benzoic amine B-221 an individualized compound I, II or IV Bordeaux B-222 An individualized compound I, II or IV Copper acetate B-223 An individualized compound I, II Or IV copper hydroxide B-224 an individualized compound I, II or IV gas oxidized copper - B-225 an individualized compound I, hydrazine or IV Γ test copper sulphate B-226 an individualized compound I, II or IV B-227 An individualized compound I, hydrazine or IV conjugated - B-228 An individualized compound I, II or IV bronopol ~~ -- B-229 An individualized compound I, II or IV thiophene Amine B-230 An individualized compound I, II or IV sulphonyl cyanide B-231 An individualized compound I, hydrazine or IV diammonium B-232 An individualized compound I, hydrazine or IV ochrexene B-233 an individual Compound I, II or IV _ 灭粉~~ B-234 An individualized compound I, II or IV via copper bismuth B-235 An individualized compound I, II or IV calcium cyclate B-236 Individualized Compound I, II or IV spirulina B-237 An individualized compound I, hydrazine or IV B-238 An individualized compound I, II or IV Ν-(cyclopropyl decyloxyimino) 6_Difluoromethoxy 2,3-difluoro-phenyl)-methyl)-2-indolyl B-239 An individualized compound I, hydrazine or IV Ν'·(4-(4 -Chloro-3-trifluoromethyl-p-oxyl&gt;21 Dimercapto-phenyl VN-ethyl-fluorenyl-fluorenyl b-240 An individualized compound I, hydrazine or IV Ν'-(4 -(4-Fluoro-3-trifluoromethyl-phenoxy)-2,5-diindenyl-phenyl-VN-ethyl-indole-indenyl B-241 An individualized compound I, hydrazine or IV Ν'-(2_Mercapto-5-trifluoromethyl-4-(3-tridecylfluorenyl-propoxy)-phenyl)-N-ethyl-N-methylformamidine B- 242 one by one Differentiation of compound I, hydrazine or IV van-(5-difluoromethylindolyl-4-(3-trimethyldecyl-propoxy)-phenyl)-N-ethyl-N-methylformamidine 149026.doc -177· 201103429 Mixture component 1 Component 2 B-243 An individualized compound I, II or IV 2-{1-[2-(5-fluorenyl-3-trifluoromethyl-pyrazole- 1-yl)-ethinyl]-piperidin-4-yl}-thiazole-4-furoate hydrazino-(1,2,3,4-tetrazo-n-yl)-bristamine B- 244 An individualized compound I, II or IV 2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethinyl]-piperidin-4-yl }-thiazole-4-decanoic acid methyl-(R)-l,2,3,4-tetrazine-cai-1·yl-bristamine B-245 an individualized compound I, II or IV acetic acid 6- Tributyl-8-oxa-2,3·diindolyl-4-ylindole B-246 An individualized compound I, II or IV methoxy-acetic acid 6-t-butyl-8-fluoro -2,3-dimethyl-wow scare&gt;-4-yl vinegar B-247 an individualized compound I, II or IV plus Poly B-248 an individualized compound I, II or IV plus Bao B-249 An individualized compound I, II or IV butyl plus Bao B-250 an individualized compound I, II or IV Na Nade thiodicarb B-251 an individualized combination I, II or IV Bifenin B-252 An individualized compound I, II or IV Safranine B-253 An individualized compound I, II or IV Saining B-254 An individualized compound I, II or IV sub-extinction Ning B-255 An individualized compound I, II or IV ζ-ambience Chrysanthemum S-B-256 An individualized compound I, II or IV Dingning B-257 An individualized compound I, II or IV Yi Bili B -258 An individualized compound I, hydrazine or IV λ-赛洛宁 B-259 An individualized compound I, II or IV Benzene B-260 An individualized compound I, II or IV Tefluthrin B-261 An individualized compound I, II or IV Fufulon B-262 An individualized compound I, II or IV Flufuron B-263 An individualized compound I, II or IV Lucendron B-264 An individualized compound I , II or IV Devalon B-265 An individualized compound I, II or IV Spirotetramat ethyl ester B-266 An individualized compound I, II or IV Cotinine B-267 An individualized compound I, II or IV Anthraquinone B-268 An individualized compound I, II or IV etadamine B-269 An individualized compound I, II or IV thiamethoxam B-27 0 An individualized compound I, guanidine or IV biting insect Yuedong B-271 An individualized compound I, II or IV. Sesinolin B-272 An individualized compound I, II or IV Endosulfan B-273 An individualized compound I, hydrazine or IV Fenpney B-274 An individualized compound I, II or IV Abatatin B-275 An individualized compound I, II or IV Inhibitor B-276 An individualized compound I, II or IV Schnauzer B-277 An individualized compound I, II or IV Spinoline B-278 An individual compound I, II or IV Volt B-279 An individualized compound I, II or IV

[SI 149026.doc -178- 201103429 Mixture component 1 Component 2 B-280 An individualized compound I, II or IV Fenbu B-281 An individualized compound I, II or IV Indomethacin B-282 Individualized compound I, II or IV fluorinated B-283 an individualized compound I, II or IV flunisamine B-284 an individualized compound I, II or IV fubenamine B-285 an individualized compound I, II Or IV chloro-amidobenzil B-286 an individualized compound I, II or IV a ghectin receptor inhibitor (HGW86) B-287 an individualized compound I, II or IV tiflumeimide B-288 An individualized compound I, II or IV acetochlor B-289 an individualized compound I, II or IV dimethacin B-290 an individualized compound 1' II or IV isopropyl valeramine B-291 Individualized compound I, II or IV ° oxalate B-292 An individualized compound I, II or IV jiaphosphonate B-293 An individualized compound I, II or IV Phytophthora B-294 An individualized compound I , II or IV thiolopine B-295 an individualized compound I, II or IV acetyl oxalic acid B-296 an individualized compound I, II or IV Fenoxaprop B-297 one kind of individual compounds I, II or IV. Bifluoxacillin B-298 An individualized compound I, II or IV ° chlorhexidine B-299 An individualized compound I, II or IV Paraquat B-300 An individualized compound I, II or IV beet Ning B-301 An individualized compound I, II or IV gram of grass with B-302 an individualized compound I, II or IV Cycloheximide B-303 An individualized compound I, II or IV Cyclopentanone B-304 An individualized compound I, II or IV chlorpyrifos B-305 an individualized compound I, II or IV from chlorpyrifos B-306 an individualized compound I, II or IV pendimethalin B-307 Compound I, II or IV Amphetamine B-308 An individualized compound I, II or IV Trifluralin B-309 An individualized compound I, II or IV Acifluorfen B-310 An individualized compound I , II or IV &gt; odor benzene guess B-311 an individualized compound I, II or IV imazethate B-312 an individualized compound I, II or IV oxazepam B-313 an individualized compound I, II or IV meidazolium nicotinic acid B-314 an individualized compound I, II or IV herbicide in B-315 an individualized compound I, II or I V 灭草, S-B-316, an individualized compound I, II or IV ° rice grass, final B-317, an individualized compound I, II or IV 2,4-dichlorophenoxyacetic acid (2,4-D) B -318 An individualized compound I, II or IV Aerosol-sensitive B-319 An individualized compound I, II or IV Becker grass B-320 An individualized compound I, II or IV Fluroxypyr B-321 Compound I, II or IV Toxicidine B-322 An individualized compound I, II or IV Flumazepam-179-149026.doc 201103429 Mixture component 1 Component 2 B-323 An individualized compound I, II or IV Bensulfuron-B-324 An individualized compound I, II or IV Ethylsulfuron-B-325 An individualized compound I, II or IV Cyclopropylidene B-326 An individualized compound I, II or IV Iodomethylsulfuron B-327 An individualized compound I, II or IV Mesulsulfuron-B-328 An individualized compound I, II or IV Mercaptomethylsulfuron B-329 An individualized compound I, II or IV Nicosulfuron B-330 An individualized compound I, II or IV Resinsulfuron B-331 An individualized compound I, II or IV gas amine sulphide B-332 Compound I, II or IV Atrazine B-333 An Individualized Compound I, II or IV Cyazinone B-334 An Individualized Compound I, II or IV Valerian B-335 An Individualized Compound I, II Or IV diflufenacil B-336 an individualized compound I, II or IV prosufon B-337 an individualized compound I, II or IV bentazon B-338 an individualized compound I, II or IV Indolinone B-339 An individualized compound I, 11 or IV cycloheptyl ether B-340 an individualized compound I, hydrazine or IV dicamba B-341 an individualized compound I, II or IV diflupiron B-342 An individualized compound I, II or IV dioxate #acid B-343 an individual compound I, hydrazine or IV quinoxalate B-344 an individual compound I, II or IV methyl chlorfenapyr B- 345 An individualized compound I, hydrazine or IV pyrithione B-346 - an individualized compound I, hydrazine or IV Topex is known as component 2 active substance, its preparation and its activity against harmful fungi It is known (see, http://www.alanwood.net/pesticides/); these materials are commercially available. The compounds described by the IUPAC nomenclature, their preparation and their fungicidal activity are also known (see, Can. J. Plant Sci. 48(6), 587-94, 1968; EP-A 141 317; EP- A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A 428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; A 1 201 648 ; EP-A 1 122 244 ; JP 2002316902 ; DE 19650197 ; DE 10021412 ; DE 102005009458 ; US 3,296,272 ; US 3,325,503 ;

[SI 149026.doc • 180-201103429 WO 98/46608; WO 99/14187; WO 99/24413; WO 99/27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; 01/56358; WO 02/22583; WO 02/40431; WO 03/10149; WO 03/11853; WO 03/14103; WO 03/16286; WO 03/53145; WO 03/61388; WO 03/66609; WO 04/74491; WO 04/83193; WO 05/120234; WO 05/123689; WO 05/123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; 06/87325; WO 06/87343; WO 07/82098; WO 07/90624). Mixtures of the active substances can be prepared in the form of compositions by conventional methods, for example, by the methods specified for the compositions of the compounds I, oxime and/or IV, which compositions comprise at least one inert ingredient in addition to the active ingredient. Ingredients. For the common ingredients of such compositions, reference is made to the explanations for compositions containing compounds I, II and/or IV. Mixtures of the active substances according to the invention are suitable as fungicides, and the compounds of the formulae I, II and IV are also suitable as fungicides. It is characterized by significant efficacy against a broad spectrum of phytopathogenic fungi, especially for fungi from the following classes: Ascomycetes, Basidiomycetes, Deuteromycetes and Oomycetes. Further, reference is made to the explanation regarding the fungicidal activity of the compound and the composition containing the compounds I, II and/or IV, respectively. The compounds I, II and IV and their pharmaceutically acceptable salts are also suitable for the treatment of diseases in humans and animals, especially as anti-mold agents for the treatment of cancer and for the treatment of viral infections. The term "anti-fungal agent" is different from the term "fungicide 149026.doc -181 - 201103429", which means an agent used against animal pathogenic or human pathogenic fungi, ie for combating animals, especially An agent for fungi in mammals, including humans, and birds. Thus, another aspect of the invention pertains to medicaments comprising at least one compound of the formula I, π and/or IV and/or at least one pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. Suitable pharmaceutically acceptable salts are, in particular, the physiologically acceptable acid addition salts of the physiologically acceptable salts of the compound I. Examples of suitable organic and inorganic acids are hydrochloric acid, hydrobromic acid, phosphoric acid, sulfuric acid, C1_C4 alkylsulfonic acid (such as sulfonic acid), aromatic sulfonic acids (such as benzoic acid and toluene), oxalic acid, Succinic acid, antibutanic acid, lactic acid, tartaric acid, adipic acid and benzoic acid. Other suitable acid systems are described, for example, in F〇rtschritte der Arzneimittelforschung, Volume 1, page ff., BirkhSuser

Verlag, Basle and Stuttgart, 1966, the entire contents of which is expressly incorporated herein by reference. Suitable carriers are, for example, solvents, carriers, excipients, binders, and the like, which are conventionally used in pharmaceutical formulations, which are described hereinafter in an exemplary manner for the particular mode of administration. Another aspect of the present invention relates to the use of Compounds I, 11 and IV or a pharmaceutically acceptable salt thereof for the preparation of an anti-fungal agent; that is, for the treatment and/or prevention of human pathogenicity and/or Or an agent for the infection of an animal pathogenic fungus. Another aspect of the invention is the use of a compound of formula j, π and/or IV or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of cancer. Another aspect of the present invention relates to the use of a compound of the formula, π and/or the compound or 149026.doc-182·201103429, a pharmaceutically acceptable salt thereof for the preparation of a medicament for the treatment or prevention of a viral infection. The compounds of formula I, II and IV and/or their pharmaceutically acceptable salts are useful for treating, inhibiting or controlling the growth and/or proliferation of tumor cells and the conditions associated therewith. Therefore, it is suitable for cancer therapy of the following animals: warm-blooded vertebrates, for example, mammals and birds, especially males, and other mammals, especially useful domestic animals such as dogs, cats, pigs, ruminants (bovine, sheep) , goats, bison, etc.), horses, and birds, such as chicken turkeys, ducks, geese, pheasants, and the like. The compounds of formulae I, II and IV and/or their pharmaceutically acceptable salts are suitable for the treatment of cancer or cancerous conditions of the following organs: breast, lung, intestine, prostate, skin (melanoma), kidney, bladder, Oral, larynx, esophagus, lunar, ovarian, pancreatic, liver and brain or CNS. The compounds of formulae I, II and IV and/or their pharmaceutically acceptable salts are suitable for treating viral sensations in the following animals: warm-blooded vertebrates, such as &quot;in animals and birds, especially males, and other mammals Especially useful for animals such as dogs, cats, pigs, ruminants (cattle 'sheep, goats, wild 2, etc.), horses, and birds, such as chickens, turkeys, ducks, geese, pheasants and their likes Things. It is suitable for the treatment of viral infections, such as retroviral infections, such as HIV and HTLV, influenza virus infection, rhinovirus infection, paratherapy and infection. 8. For example, the active compound can be embedded in the hard by the mouth or vein, and the compound of the present invention can be administered intramuscularly, intramuscularly or subcutaneously in a conventional manner. For oral administration, such as an inert diluent or an edible carrier; 149026.doc -183- 201103429 or a soft gelatin capsule, it can be compressed into a lozenge or it can be mixed directly with the food/feed. The active compound may be mixed with excipients and administered in the form of indigestible elixirs, buccal tablets, tablets, pills, capsules, suspensions, liquids, syrups and the like. These preparations should contain at least 1% active compound. The composition of the formulation may of course vary. It is usually included in an amount of from 2 to 60% by weight of the active compound, based on the total weight of the relevant formulation (dosage unit). Preferred formulations of Compound I of the present invention comprise from 10 to 1000 mg of active compound per oral dosage unit. Further, 'tablets, tablets, pills, capsules and the like may contain the following components: binders such as tragacanth, acacia, corn starch or gelatin; excipients such as calcium hydrogen phosphate; disintegrants, Such as corn starch, potato starch, alginic acid and the like; a glidant such as magnesium stearate; a sweetener such as sucrose, lactose or saccharin; and/or a flavoring agent such as pepper 4, vanilla and the like Things. Additionally, the capsules can contain a liquid carrier. Other substances of modified dosage unit properties may also be used. For example, tablets, pills and capsules may be coated with scheUack, sugar or mixtures thereof. The syrup or drink may contain, in addition to the active compound, a sugar (or other sweetener), a methyl p-hydroxybenzoate or a propyl paraben, a colorant and/or a flavoring agent as a preservative. Of course, the components of the active compound formulation must be pharmaceutically pure and non-toxic in the amounts employed. Further, the active compound may be formulated as a formulation for controlled release of the active compound, such as a delayed release formulation. The active compound can also be administered parenterally or intraperitoneally. The solution or suspension of the active compound or its salt can be prepared in water using a suitable wetting agent such as hydroxypropylcellulose. ★ ^ It is also possible to use glycerin, liquid polyethylene glycol and its preparation in oil to prepare a dispersion. These formulations often additionally contain a preservative to prevent microbial growth. The preparation for human injection includes a sterile aqueous solution and a dispersion, and a sterile powder for preparing a liquid preparation and dispersion liquid. The formulation must have sufficient flow for steepness/main shot. It must be stable under the conditions of manufacture and storage and must be protected from microbial contamination. The carrier can be a solvent or dispersion medium such as X-ethanol, oxime (e.g., glycerol, propylene glycol or liquid polyethylene glycol) and mixtures thereof and/or vegetable oils. [Embodiment] The present invention will be further illustrated by the following non-limiting examples. I. Synthesis Example II. Examples of the action against harmful fungi The fungicidal action of the compounds of the formulae I and II is demonstrated by the following experiments: A) Microtitration test The active substance is separately formulated into a stock solution in disulfoxide (DMS0). 'The concentration is 10 〇〇〇ppm. Use example 1. In the microtiter test against the activity of Phytophthora infestans in late blight pathogens. Store the stock solution in a microtiter plate (MTP) and dilute it to the specified activity using a pea juice-based aqueous nutrient medium for fungi. Substance concentration. An aqueous suspension of zoospores of Phytophthora infestans is then added. Place the disk i in a room where the water vapor at a temperature of .18 ° C is saturated. MTP was measured at 405 nm on the 7th day after inoculation using an absorbance luminosity t10. The measured parameters 149026.doc .185- 201103429 were compared to the growth of control variants (=100%) without active substance and compared to blank test values without fungi and active substances to determine the pathogen % relative growth in individual active substances. Use example 2: Against the activity of the rice blast pathogen caused by P. sphaeroides in a microtiter test. Inject the stock solution into a microtiter plate (MTP) and dilute it with a malt-based aqueous nutrient medium for fungi. To the specified active substance concentration. An aqueous suspension of spores of P. sphaeroides was subsequently added. The disk was placed in a room saturated with water vapor at a temperature of 18 °C. The microtiter plate was measured at 405 nm on the 7th day after inoculation using an absorption photometer. Comparing the measured parameters to the growth of the control variant (=1%%) without active substance and comparing it to the blank test value without fungi and active substance to determine the pathogen in the individual active substance Relative growth 0 / 〇. Use Example 3: Resistance to the pathogen of the Phytophthora sphaeroides caused by Phytophthora hirsutum in a microtiter test. Inhalation of the stock solution into a microtiter plate (MTP) and use of malt-based water-based nutrients for fungi The medium is diluted to the specified active substance concentration. An aqueous suspension of spores of S. hirsutum was subsequently added. The disk was placed in a room saturated with water vapor at a temperature of 18 °C. The microtiter plate was measured at 405 nm on the 7th day after inoculation using an absorption photometer. The measured parameters were compared to the growth of control variants (=100%) without active substance and compared to blank test values without fungi and active substances to determine the relative growth of pathogens in individual active substances. %. B) Greenhouse test 149026.doc •186- 201103429 The active substance is formulated separately or together to a stock solution containing 25 mg of active substance 'Using acetone and/or dimethyl hydrazine (DMSO) with emulsifier Wettol EM 3 1 (with emulsification) And a mixture of dispersing ethoxylated oxime-based wetting agents) is supplemented by a solvent/emulsifier 99:1 volume ratio! 〇 ml. The solution is then made up to 10 〇 m with water and the stock solution is diluted with the solvent/emulsifier/water mixture to the concentration of active substance given below. Use Example 4: Protective application against the activity of Phytophthora infestans caused by Phytophthora infestans Tomato plant seedlings were grown in pots. The plants are sprayed with an aqueous suspension containing the active substance concentrations specified below until overflowing. On the next day, the treatment group was inoculated with an aqueous suspension of Phytophthora infestans sporangia β immediately after inoculation, and the test plants were immediately transferred to a humid chamber. Visually assess the degree of fungal attack on the leaf after 6 days of exposure to ^··· and close to 100% relative humidity, expressed as % of diseased leaf area. Use Example 5. Fight against Puccinia reticulata on wheat (wheat) Therapeutic effect of brown rust) The potted wheat seedling leaves of the cultivar "Kanzler" were sprayed with a spore suspension of wheat brown rust (Puccinia recondita). The plants were then placed in a high atmospheric humidity (90 to 95%) and a room at 20-22 C for 24 hours. During this time, the buds sprouted and the buds penetrated into the leaf tissue. The next day, the infected plants were sprayed with an aqueous suspension having the concentration of active substance specified below until the overflow point. After drying through the spray suspension, the test plants were returned to the greenhouse and cultured for a further 7 days at a temperature between 2 and 22 C and a relative atmospheric humidity of 65 to 70%. 149026.doc -187 - 201103429 The extent of rust progression on the leaves was then visually observed. Use example 6: Protective effect against Puccinia glabrata (wheat brown ore) on wheat Spraying the potted wheat seedling leaves of the cultivar "Kanz丨er" with an aqueous suspension having the active substance concentration specified below The flow point is up. The sputum was sprayed with a spore suspension of wheat brown rust (Puccinia recondita) and the plants were then placed in atmospheric humidity (90 to 95%) and 20-22 ° C for 24 hours. During this time, the spores germinate and the germ tubes penetrate into the leaf tissue. On the next day, the test plants were returned to the greenhouse and cultured for a further 7 days at a temperature between 65 °C and 70% of the relative atmospheric humidity. The extent of rust progression on the leaves was then visually observed. Use of a protective effect against the wheat powdery mildew (wheat powdery mildew) on wheat (7): water-based (10) potted wheat seedlings of the "Kanz丨er" cultivar "Kanz丨er" with the active substance f concentration specified below Leaves up to the overflow point. Sub-J whitening disease (wheat powdery mildew), the suspension of the scorpion suspension, and the plants (3⁄4 after returning the plants to the greenhouse and at a temperature between the 2nd generation and the relative atmospheric humidity of 90/. The culture was carried out for 7 days. Then the degree of powdery mildew progress on the leaves was visually observed. Example 8: The protective effect against the cucurbits of the genus Pleurotus ostreatus (courgette powdery mildew) on the melons to have the following activities The aqueous suspension of the substance f concentration sprayed the leaves of the courgette seedlings (at the stage of the germ layer) until the overflow point. The next day, the group of plants was treated with the spore suspension of the melon powdery mildew (C. sinensis). Subsequently [S1 149026. Doc -188· 201103429 The plants are returned to the greenhouse and cultured for a further 7 days at a temperature between 20 and 24 ° C and a relative atmospheric humidity of 60 to 80%. The degree of powdery mildew progression on the cotyledons is then visually observed. 149026.doc - 189-

Claims (1)

201103429 VII. Scope of application for patents: 1. Triazole compounds of formula I and II, Ύ is 3 or 2 heteroatoms selected from ruthenium, osmium and S as a 3-"-saturated, partially unsaturated or; ring: wherein the heterocyclic ring may have 1, 2, 3 or 4 substituents 5., Α is a linear c-base bridge which can be substituted by 2, 3 or 4 substitutions (4); WY R1 is Ο, S or NR8; R2, R3 and R4 are independently selected from hydrogen , dentate, 〇h, cation, N02, CN, CVQ alkyl, Ci_C4i alkyl, c2_C4 alkenyl, c2-c4 alkenyl, c2-c4 alkynyl, C2_C4 haloalkynyl, C3_C8 cyclocaryl, c3- C8 halocycloalkyl '(^匕alkoxy, Ci_c4_alkylidene, C丨-C4 alkenyloxy, CVC4 haloalkenyloxy, c"cv alkynyloxy, CrC:4haloalkynyloxy, C3- Cs cycloalkoxy, C3_C8 halocycloalkane, c丨-C4 alkylthio, C丨-c4 haloalkylthio, CVC4 alkenylthio, Ci-C4 alkynylthio, phenyl, stupyl_Ci_C4 Alkyl, phenyl-Ci_c4 alkoxy, phenoxy, phenylthio, wherein the phenyl moiety of the last five mentioned groups may have 1, 2, 3, 4 or 5 substituents R9; .doc 201103429 1, 2 or 3 heteroatoms selected from N, 〇 and S as ring members 3_, ? 5-, 6- or 7-satisfy And a partially unsaturated or a maximum unsaturated heterocyclic ring wherein the §heheheterocyclic ring may have 1, 2 or 3 substituents R9. C〇R^COORl〇, CONRl5Rl6, NRlVis((^Ri〇', wherein the above group The aliphatic moiety may have i, 2 or 3 substituents R18, and wherein the cycloaliphatic moiety of the above group may have i, 2 or 3 substituents R19; or R1 and R2, or R3 and R4, Together with the carbon atoms to which they are attached, form a partially unsaturated or maximally unsaturated 5, 6 or 7-membered carbocyclic ring, or contain 2 or 3 heteroatoms selected from the group consisting of ruthenium and SaN as ring members: a saturated or maximally unsaturated 5-, 6 or 7-membered heterocyclic ring; wherein the carbocyclic or heterocyclic ring may have 1, 2 or 3 substituents r9; each R5 is independently selected from the group consisting of _, 0, SH, N 〇2, CN, L 1 ·14 soil, CVC4 tooth base, c2-c4 thin base, c2_c4 _ alkenyl, alkynyl, c2-c4 _ alkynyl, c3_c^ appearance base, c3_c^ ring hospital 4 base, CVC4, alkoxy, cvc4, alkoxy, Ci_c4, dioxyl, CVC4, butylene, cvc: 4 alkynyl, C, _C4, haloalkoxy, C8 cycloalkoxy, c3-c8, cycloalkoxy Base, Ci_C4 alkyl sulfide ^ C4i alkylthio group, (^-(^-enethio group, Ci_c4_) Thio group, phenyl 1 phenyl-q-C4 alkyl group, phenyl-Cl_C4 alkoxy group, phenoxy 'phenylthio group, wherein the phenyl moiety in the last 5 mentioned groups may have 丨^2 3, 4 or 5 substituents containing 2 or 3 selected from the hetero atom of N, 〇 and S as ring members 3...4_, 5_, 6 sentences _ member saturated, partially unsaturated or maximum unsaturated a ring wherein the heterocyclic ring may have 149026.doc [SI 201103429 has 1, 2 or 3 substituents R9; COR10, COOR10, C〇NR] 5R16, NR15R16 and S(0)p R10, wherein the lipid in the above group The moiety may have 1, 2 or 3 substituents R18, and wherein the cycloaliphatic moiety of the above group may have 1, 2 or 3 substituents R19; or two groups attached to adjacent ring atoms R5, together with the ring atom to which it is attached, forms a partially unsaturated or maximally unsaturated 5-, 6- or 7-membered carbocyclic ring' or contains 1, 2 or 3 heteroatoms selected from the group consisting of ruthenium, S and N as ring members. a partially unsaturated or maximally unsaturated 5-, 6- or 7-membered heterocyclic ring; wherein the carbocyclic or heterocyclic ring may have i, 2 or 3 substituents 9; R6 is selected from the group consisting of hydrogen, cvcw, and c ^-c, C2-C,. Alkenyl, C2_Ciq fast radical, decentral, c2-C10 dilute, co-group, C2-Ci〇 halo block, C3-Ci 149026.doc cycloalkyl, C3-c10_cycloalkyl, phenyl, benzene Base _Ci_C4 alkyl, -, μ θ ti’j 5 - or 6-member saturated, partially unsaturated HI group A 201103429 wherein Het, A, Υ, r1, R2, r3 and r4 are as defined in formulas j and π; and # is the point of attachment to the rest of the molecule; R is selected from hydrogen, Ci-CiQ stimuli, C〗 - C1Q Toothing "Base, C2-C1 () dilute, c2-c10ii alkenyl, C2_Ci 〇 fast radical, C2_Ci 〇 haloalkynyl, C3_Ci 〇 % alkyl, C ^ Cio halocycloalkyl, phenyl a phenyl-CVC4 alkyl group, wherein the phenyl moiety in the last two mentioned groups may have 1, 2, 3, 4 or 5 substituents R11, containing ruthenium, 2 or 3 selected from n, oxime and a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring having a hetero atom of S as a ring member, wherein the heterocyclic ring may have 1, 2 or 3 substituents R 丨丨 ' -C( = 〇)R丨2, _C(=S)Ri2, _s(〇)2Rl2, _CN, -P(=Q)R13R14 and Μ; each R7 is independently selected from the group consisting of halogen, hydrazine, SH, NR15R16, (^-(:4) Base, cvcu dentate group, C2-C4 alkenyl group, C2_C4|i fluorenyl group, c2_c^ group, c2-c4 haloalkynyl group, CVC4 alkoxy group, Ci-C4 haloalkoxy group, C1-C4 sulfur-burning group and c "C4 halogen thio, wherein the aliphatic moiety of the above group may have 1, 2 or 3 substituents R18; or Two groups on adjacent carbon atoms together with the carbon atom to which they are attached form a 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated carbon ring' or contain 1, 2 or 3 3-, 4-, 5-, 6- or 7-membered saturated, partially unsaturated or maximally unsaturated heterocyclic rings selected from the group consisting of a hetero atom of hydrazine, S and N as a ring member, wherein the carbocyclic or heterocyclic ring The ring may have 1, 2 or 3 substituents R9; ί 149026.doc 201103429 R8 is selected from the group consisting of hydrogen, CN, (VC4 alkyl, CVC4 dentate, c2-c4 alkenyl, c2-c4 alkenyl, C2_C4 Alkynyl, c2_C4li alkynyl, Ci_c4 alkoxy 'C, -C4 haloalkoxy, phenyl, phenyl-Cl_c4 alkyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2 3, 4 or 5 substituent base 9; c〇Rio, c〇〇R10, c〇nr15r16 and S(0)pR10; each R9 is independently selected from halogen, 〇H, SH, NRi5R16, CN, N02, Cl -C4 alkyl, Ci-C4 _ alkyl, C2-C4 alkenyl, C2-C4-alkenyl, c2-c4 alkynyl, c2_C4-alkynyl, Ci_C4 decyloxy, Ci-C4 haloalkoxy, Ci a -C4 alkylthio group and a Cl_c4_alkylthio group, wherein the aliphatic moiety in the above group may have 1, 2 or 3 substituents R18; each Han 10 is independently selected from the group consisting of hydrogen, C, -C4 alkyl, Cl_C4_alkyl, C2_C4, C2_C4 haloalkenyl, C丨-C4 aminoalkyl, phenyl, phenyl _ The phenyl moiety of the C 2 -C 4 alkyl group wherein the last 2 of the groups may have 1, 2 3, 4 or 5 substituents R 9 and 1 , 2 or 3 hetero atoms selected from the group as ring members a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic ring wherein the heterocyclic ring may have i, 2 or 3 substituents R9; each independently selected from the group consisting of arginine, hydrazine H, SH, NRi5R16, CN, N02, Cl C4 alkyl, Cl~C4 _院, C2-C4 alkenyl, C2-C4 haloalkenyl C2 C4 block &quot; base, C2_C4 _ alkynyl, CVC4 alkoxy, CVC4 halogen alkoxy , a — « h-sulfuryl group and (^-(: 4-haloalkylthio group, wherein the aliphatic moiety of the above 12 groups may have 1, 2 or 3 substituents R18; R 2 is selected from hydrogen, K γ ρ 10 炫, CrC!—alkyl, CVCu, 149026.doc 201103429, CrCw haloalkoxy, CrCw aminoalkyl, c3-c] 0 ring alkyl, C3_C丨〇 halocycloalkyl Phenyl, phenyl-C]-C4 alkyl, of which the last two refer to the phenyl moiety in the group a 5- or 6-membered saturated, partially unsaturated or aromatic having 1, 2, 3, 4 or 5 substituents R11' containing 1, 2 or 3 heteroatoms selected from N, fluorene and S as ring members a heterocyclic ring wherein the heterocyclic ring may have 1, 2 or 3 substituents R11, and NRI5R16; R13 and R14 are independently of each other selected from C-C alkyl, C丨-C丨〇 haloalkyl, CVC ,. Dilute, C2-C1()i alkenyl, C2-C,. Alkynyl, C2-C10l|alkynyl, (3-(:10-cycloalkyl, C3-C)-halohalocycloalkyl, CVCw alkoxy, CVCw haloalkoxy, CVC4-alkoxy-CVCw , Ci-C4-alkoxy-oxime:--: (: () alkoxy, Ci-Cw alkylthio, Ci-C, haloalkylthio, (: 2-(: 10 diloxy) , C2-C10-enylthio, (: 2-(:10 alkynyloxy, C2-CiG-fast thio, C3-Ci() ring alkoxy, C3-C1()-cycloalkylthio, benzene a group, a phenylalkyl group, a phenylthio group, a phenyl c4 alkoxy group, and NR15R16; each R15 is independently selected from the group consisting of hydrogen and c--c8 alkyl; each R16 is independently selected from the group consisting of hydrogen, Ci-C8 alkyl, and benzene. And phenyl-Ci-Q alkyl; or R 5 and R16 together form a linear C4 or (1! 5 stretching bridge or group -CH2CH2〇CH2CH2- or _ch2ch2nr17ch2ch2-; each R17 is independently selected from Hydrogen and (: 1-(:4 alkyl; each independently selected from nitro, CN, OH 'SH, COR丨0, COOR1., c〇NR15R16, NR15R16, C3-C4 alkyl, c3_149026.doc 201103429 C6 dentate, (^-alkenyloxy, CVC4 haloalkoxy, c3_c6 % cycloaloxy, phenyl and phenoxy; each R is independently selected from the group consisting of trityl, CN, OH, SH , COR1 0, c〇〇R10, c〇NR15R16, nr15r16, Cl_c4, Ke_c4, 匚3-(26 ring alkyl, C3-C6 halocycloalkyl, C1-C4 alkoxy, Ci-C: 4-haloalkoxy, Cs-C: 6 cycloalkoxy, phenyl and phenoxy; Q is 0 or s; M is a metal cation equivalent or an ammonium cation of the formula (NRaRbR(:Rd)+, wherein Ra , Rb, Rc and Rd are independently of each other selected from the group consisting of hydrogen, C|_C丨〇alkyl, phenyl and benzyl, wherein the phenyl moiety in the last two mentioned groups may have 1, 2 or 3 independently Substituents selected from the group consisting of halogen, CN, schlossyl, Cl_C4 alkyl, Ci_C4i|, Ci_C4 oxy, (VC4 haloalkoxy and NR15R16; m is ο, 1 or 2; and Ρ is 1 or 2 And an agriculturally acceptable salt thereof. 2-. The compound of the formula I and II of the stomach of claim 1, wherein Het is a ring member having 1, 2 or 3 hetero atoms selected from N, oxime and S. a 5- or 6-membered heteroaryl ring, wherein the heteroaryl ring may have 1, 2, 3 or 4 substituent bases 5. 3. A compound of the formulae I and II according to claim 2, wherein Het is selected from the group consisting of pyridine Base, pyrimidinyl, furyl, thienyl, pyrrolyl, pyrazolyl, imidazole a 5- or 6-membered heteroaryl ring of oxazolyl, isoxazolyl, thiazolyl, isothiazolyl and triazolyl, wherein the heteroaryl ring may have hydrazine, 2, 3 or 4, preferably ^ 149026.doc 201103429 or 2 substituents r5. 4. The compound of the formula I and π of claim 3, wherein Het is a 5- or 6-membered heteroaryl ring selected from pyridyl, porphinyl and thiazolyl, preferably pyridyl, wherein the heteroaryl ring There may be 1, 2, 3 or 4, preferably 1 or 2 substituents R5. The compound of the formulae I and II according to any one of the preceding claims, wherein R!, R2, R3 and R4 are independently of each other selected from the group consisting of hydrogen, dentate, hydrazine H, SH, N02, CN, CVC4 alkyl, Cl-C4 haloalkyl, CVC4 alkoxy, alkoxy, Cl-C4 alkoxy-C!-C4 alkoxy and (^-(:4 halooxy) are preferably selected from hydrogen and fluorine. , chloro, bromine, Cl_C4 alkyl, Cl_c4 ifixanyl, C丨-C4 alkoxy and C丨-C4 haloalkoxy. 6. A compound of formula I and π according to any of the preceding claims, Wherein each ruler 5 is independently selected from the group consisting of self-priming, 0H, SH, N〇2, CN, C]_C4 alkyl, Ci_C4 functional alkyl, C"C4 alkoxy-Cl-C4 alkyl, CVQ alkoxy, Cl_C4 alkoxy-CrC4 alkoxy group and Cl-C4 haloalkoxy group, preferably selected from the group consisting of gas, gas, bromine, Ci-C4 alkyl, c, _c4_alkyl, Cl_c4 alkoxy and halothane 7. A compound of the formula 11 and 11 according to any one of the preceding claims, wherein the compound is selected from the group consisting of Cl-C4 alkyl, Ci-C2 dentate alkyl, c--c4 alkoxy, Ci_c2i alkoxy. And phenyl, phenoxy and NR15R16, wherein R15 is hydrogen, R16 is selected from nitrogen, (VC base and stupid, or RijRi6 are all Ci_C4 hospital base. 8. The compound of any one of the preceding claims, wherein r6 is selected from the group consisting of hydrogen, Ci-C4 fluorenyl, _c(=〇)r!2, _s(〇)2Ri2, CN, m and formula III [SI 149026.doc 201103429 9. The compound of the formulae I and II of claim 8, wherein R6 is selected from the group consisting of gas, methyl, ethyl, propyl, isopropyl, ·&lt;: (=0 (: Η3,, -C(=0)N(CH3)2, CN, a group of formula III, an alkali metal cation, and a % Cu2+ 〇10. A compound of formulas I and II according to any of the preceding claims. And wherein Rea is selected from the group consisting of hydrogen, (^(:4 alkyl, -S(0)2R12, and -C(=0)R12. 11. The compound of formula I and hydrazine according to any one of the preceding claims, wherein A is a linear C2 or C3 alkylene bridge where the gas atom of the alkylene bridge can be replaced by 1 or 2 substituents R7, wherein each R7 is independently selected from the group consisting of Ci_c4, eve* haloalkyl, cvq Alkoxy, cvc4 alkoxy_Ci_C4 alkoxy and C^-C4 halo alkoxy, preferably selected from methyl, ethyl, methoxy, ethoxy and methoxymethoxy, or linked Two substituents R7 on adjacent carbon atoms together with the carbon atom to which they are attached form a cyclopentyl group The compound of the formula 1 and the compound of any one of the preceding claims, wherein γ is Ο. 13. A compound of the formula of any of the preceding claims, hexamidine. 14. A compound of formula IV, Wherein Het, A, Υ, R1, R2 R3 and R4 are as defined in claims 1 to 6 and 11 149026.doc 201103429 to 13. 15 16. 17. 18. 19. 20. 21. An agricultural composition comprising at least one compound of the formulae I, 11 and/or 1V as claimed in claims 1 to 14 or an agriculturally acceptable salt thereof And a liquid or solid carrier. A use of a compound of the formulae of any of claims 1 to 14 and/or IV for controlling harmful fungi. - a method for controlling harmful fungi, wherein the fungus, its habitat or a material or plant protected by fungi, or soil or propagation material is an effective amount of at least - a compound of the formula and/or 1 The compound Ι, π &amp; ιν is as defined in any one of claims 1 to 14. ', a seed, each (10) kg of seeds comprising at least one of Formula I, Π and/or from U gram to 1 G kg. A compound, wherein the compound is as defined in any one of claims 1 to 14. A pharmaceutical composition comprising at least one compound of the formula I, π and/or ... according to any one of the claims m Or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier. A compound of the formula I, II and/or according to any one of claims 1 to 14 or a pharmaceutically acceptable compound thereof Use of a salt for the preparation of a medicament for the treatment of cancer or a viral infection or for the preparation of an anti-fungal agent. A method of treating a cancer or a viral infection or combating an animal pathogenic or human pathogenic fungus, comprising At least - such as request items] to 14 Any of the compounds of formula I, II and/or IV, at least an acceptable salt or a pharmaceutical composition according to claim 19, 149026.doc -10· i S] of a pharmaceutical treatment thereof 201103429 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbolic symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: LSI 149026.doc