TW201041599A - Oral compositions and uses thereof - Google Patents

Abstract

The present invention is directed to oral compositions comprising an orally-acceptable carrier and a silica abrasive comprising a precipitated amorphous silica compound having an average particle size of from 5 μ m to 20 μ m, oil absorption of from 60 cc/100 g to 120 cc/100 g, and an Einlehner hardness of from 4 to 11, and methods of use thereof.

Description

201041599 VI. Description of the invention: [Technical field to which the invention pertains] The present invention relates to an oral composition comprising an orally acceptable carrier and a cerium oxide cerium abrasive comprising 5 to 20 The method is to use a precipitated amorphous cerium oxide compound having an average particle diameter of '60 cc/1 〇〇g to 12 〇cc/1 〇〇g and an Einlehner hardness of 4 to 11. ^ 〇 〇 [Prior Art] Background of the Invention The composition of the oral composition is removed and the surface of the teeth is scrubbed on the body. This scrub removes the organic biofilm on the surface of the tooth) / it is mainly composed of saliva protein, bacteria, and bacterial by-products: the film can also be used by foods (such as ♦ morphine, tea and berries) and bedding And staining and discoloration of the chromogenic bacteria. The physical removal of the soiled film removes unwanted surface names and effects that occur daily in an early and effective manner. In addition, the (4) membrane physically removes 2 bacteria, thereby minimizing the possibility of gingivitis, dental plaque, and sputum formation. = And 'oral compositions such as dentifrice should not have potential damage to the enamel or tissue. Therefore, the name f ^ caused the composition, which perfected the oral group silk: two minimized the harmful grinding purity to avoid the potential damage of the second surface force 2 3 film clean ratio (PCR), but the low degree of dental grinding Measurement 1 is radioactive tooth wear (radioactive de-abrasion, RDA). 3 201041599 In conventional routines, the rda value of the oral composition is usually kept below 25G to avoid damage to the enamel/tooth quality (Μ11). However, in order to achieve higher PCR, the amount and hardness of the abrasive must be typically increased, which is conventionally known to increase. For example, it has been observed that when the RDA value of the dentifrice composition exceeds a certain number (for example, above the point of arrival), the dentifrice does not have to be added to the dentifrice m result. An oral composition having a PCR greater than 80 丨 90 but still having an RDA remaining 25 Å has been challenged. SUMMARY OF THE INVENTION The present invention has surprisingly found that the use of special cerium oxide abrasives in oral care compositions imparts excellent cleansing power (e.g., high PCR values) while at the same time reducing damage to hard tooth surfaces (e.g., low). PDA). The cerium oxide abrasive used in the present invention maintains its integrity while wiping off soft substances such as plaque and film on the surface of the teeth. However, the cerium oxide abrasive breaks or breaks under shear (e.g., during brushing) as a result of interaction with the hard enamel or dentate surface. In this regard, the oral compositions of the present invention provide excellent cleansing and/or polishing benefits while minimizing the desired low RDA for potential damage to enamel or dentin. In addition, the compositions of the present invention provide cleansing and/or polishing of the tooth surface. Clean and/or polished abrasives can be classified by various physical parameters. As will be appreciated by those skilled in the art, a single abrasive species typically performs at least some $, Λ polishing at the same time. In one embodiment, the invention relates to a composition L〇, an oral composition comprising an orally acceptable carrier and a cerium oxide abrasive, the 201041599 oxidized stone cerium abrasive comprising an average particle having a range of 5 μm to 20 μm Diameter, and 4 to 11 Einlehner hardness of the dioxide dioxide compound. The additional composition of the present invention is the following composition: 1.1 Composition 1.0 wherein the silica dioxide has an average particle diameter of from 8 μm to 11 μm, such as from 9 μm to 13 μm. 1.2 Composition 1.0 or 1.1 wherein the cerium oxide abrasive has a sorption capacity of from 60 cc/100 g to 120 cc/100 g, such as from 70 cc/100 g to 110 cc/100 g, such as from 80 cc/100 g to 100 cc/100 g, such as linseed oil absorption. 1.3 Any of the preceding compositions wherein the oxidized chopped abrasive has an Einlehner hardness of from 5 to 10, such as from 6 to 9. 1.4 Any of the foregoing compositions having a film clean ratio (PCR) of from 80 to 105, such as from 85 to 100, or from 90 to 95; 1.5 any of the foregoing compositions having less than 150, such as from 90 to 130, from 100 to 120 Or radioactive dentin abrasion 5 RDA of 1.6 to 115; 1.6 any of the foregoing compositions having a PCR/RDA ratio of 0.5 to 1.5, such as 0.8, or 1; 1.7 any of the foregoing compositions, wherein The silica stone cerium abrasive is from 1% by weight to 95% by weight of the composition. 1.8 Any of the foregoing compositions, wherein the SiO2 has an d10 of from 2.5 μm to 2·9 μm; 1.9 any of the foregoing compositions, wherein when the oral composition is applied to a hard surface of the oral cavity (such as enamel or Tooth quality), cerium oxide abrasive broken; 5 201041599

The above-mentioned grouping wire, when the towel is used in the composition of the oral towel, the dioxo prior abrasive is broken into a composition having a size of '2.3_ to 2.6 μπι==--the above-mentioned composition, wherein when subjected to a sufficient amount of time, the shear force is sought 'The dioxide dioxide ruptures. Io composition 1 > 9 to U1' wherein the oral composition is brushed on the teeth for at least 30 seconds to 5 minutes; 1.13 any of the compositions 19 to 112, wherein after application to the hard surface in the mouth, The average particle size of the cerium oxide cerium abrasive is reduced by 16% to 2% by weight; 1.14 any composition L9 to U3, wherein after application to the hard surface in the oral cavity, the yttrium oxide of the cerium oxide is reduced by 9% to 12%. 1.15 Any of the foregoing compositions, including an effective amount of a vaporized salt, such as from 〇〇ι 重里% to 2% by weight, such as from 11% by weight to 〇2% by weight of the total composition weight. The composition comprises a source of fluoride ions comprising: selected from the group consisting of tin (II) fluoride, sodium fluoride, potassium hydride, sodium monofluoroacetate, sodium fluorocarbonate, ammonium fluoroantimonate, amine fluoride, fluorine Amine fluoride ammonium fluoride, and combinations thereof fluoride salts. 1.17 Any of the foregoing compositions comprising 500 to 5 Torr, 1 Torr to 1500, or 1450 ppm fluoride ion. A composition as described above which comprises at least one surfactant. 1.19 Any of the foregoing compositions At least one surfactant selected from the group consisting of sodium lauryl sulfate, cocoamidopropyl beet, and combinations thereof. 0 201041599 i.20 Any - "constituent" which includes an anionic surfactant. (3) Any of the foregoing A composition comprising sodium lauryl sulfate. 1.22 Any of the foregoing compositions comprising at least one humectant. 1.23 Any of the foregoing compositions comprising at least one humectant selected from the group consisting of glycerin, sorbitol, and combinations thereof. 1.24 Any of the preceding compositions comprising at least one of the preceding compositions comprising at least one selected from the group consisting of polyethylene glycol, polyvinyl sulfhydryl bond maleic acid copolymer, multifaceted (eg, fiber) a derivative of a derivative, such as carboxymethylcellulose, or a polysaccharide gum, such as dimethoate or carrageenan, and combinations thereof. 1.26 Any of the foregoing compositions, including flavorings, aromas, and/or colorants 1.27 Any of the foregoing compositions, comprising an antibacterial agent. 1.28 Any of the foregoing compositions' which comprises a halogenated diphenyl ether (dioxane), a extract of Zhuoben or an essential oil (such as rosemary) Extract, thyme, menthol, eucalyptus, methyl salicylate), biguanide preservatives (such as chlorhexidine, alexidine or octenidine), quaternary ammonium Compounds (such as cetylpyridinium chloride), phenolic preservatives, hexetidine, povidone iodine, delmopinol, salifluor, metal ions (such as zinc salts, For example, zinc citrate), blood root base, proP〇lis, and an oxidizing agent (such as hydrogen peroxide, a balance of sodium persulfate or sodium percarbonate). 7 201041599 1.29 Any of the foregoing compositions comprising triclosan. 1.30 Any of the foregoing compositions comprising an antibacterial agent in an amount of from 0.01 to 5, from 0.01 to 1.0, or 0.3% by weight of the total composition. 1.31 any of the preceding compositions, comprising a tooth desensitizing agent; 1.32 any of the foregoing compositions comprising a tooth selected from the group consisting of a potassium salt, a capsaicin, an eugenol, a phosphonium salt, a zinc salt, a chloride salt, or a combination thereof. Sensitizer; 1.33 Any of the foregoing compositions, comprising a tooth whitening compound; 1.34 any of the foregoing compositions, which is a tooth powder; 1.35 any of the foregoing compositions, comprising water; 1.36 any of the foregoing compositions, which is a toothpaste Or gel. 1.37 Any of the preceding compositions, wherein the RDA of the oral composition is calculated by the following method comprising applying 1 to 5 ml of the oral composition slurry to a surface of 1 to 10 cm2 to contact the surface of the 32P-emitted tooth, at 2 A constant force of up to 5 Newtons wipes the tooth surface 300 strokes, wherein each stroke causes the surface to move 1 to 10 cm2 of the tooth and measure the RDA value. 1.38 Any of the preceding compositions, wherein when the composition is applied to the oral cavity (e.g., in contact with a hard tooth surface), the RDA of the composition decreases over time, and the RDA of the oral composition is calculated by the method identified in 1.37. However, the book is that the number of trips utilized at the initial time A is less than the number of trips used at a later time B, such as 300 strokes equal to about 2 minutes of brushing; 1.39 any of the foregoing compositions, wherein 5 seconds of oral cavity is used in the oral cavity 201041599 The RDA of the composition was used in the oral cavity for 1.3 to 1.6 times the RDA of 1 to 5 minutes (e.g., 2, 3, or 4 minutes). 1.40 Composition 1.39, wherein the surface is a clean head of a toothbrush; 1.41 composition 1.39 or 1.40, wherein the method of calculating RDA is that the slurry comprises from 50% to 100% by weight of the oral composition. 1.42 Any of the foregoing compositions wherein the Einlehner hardness is measured in brass nets per 174,000 revolutions. 1.43 Any of the compositions 1 · 0 to 1.41, wherein the Einlehner hardness is measured in brass nets per 100,000 revolutions. 1.44 Composition 1.42 or 1.43, wherein the Einlehner hardness is 100 g of a slurry of cerium oxide abrasive in 1 liter of water. 1.45 Any of the preceding compositions wherein the aqueous slurry of 10% cerium oxide abrasive has a PCR of from 65 to 80, such as from 68 to 76, or 72. 1.46. Any of the foregoing compositions, wherein the aqueous slurry of 10% cerium oxide abrasive has an RDA of from 75 to 91, such as from 79 to 87, or 83; 1.47, any of the foregoing compositions, wherein the aqueous slurry of 10% cerium oxide abrasive has The PCR/RDA ratio is from 0.7 to 0.9, such as from 0.8 to 0.9', such as 0.86; 1.48, any of the foregoing compositions, wherein 15% of the aqueous slurry of the dioxide dioxide has an PCR of 68 to 84, such as 62 to 80, or 76. 1.49 Any of the preceding compositions, wherein the aqueous slurry of 15% cerium oxide abrasive has an RDA of from 85 to 105, such as from 90 to 100, or 95; 1.50 of any of the foregoing compositions, wherein the aqueous slurry of 15% cerium oxide abrasive has The PCR/RDA ratio is from 0.7 to 0.9, such as from 0.76 to 〇.8 '201041599, such as 0.86; 1.51, any of the foregoing compositions, wherein the aqueous slurry of 20% of the dioxide dioxide has an PCR of 76 to 92, such as 80 to 88, Or 84. 1.52 Any of the foregoing compositions, wherein the aqueous slurry of 20% cerium oxide abrasive has an RDA of 85 to 101, such as 89 to 97, or 93; 1.53, any of the foregoing compositions, wherein the aqueous slurry of 20% oxidized abrasive has The PCR/RDA ratio is from 0.8 to 1.0, such as from 0.85 to 0.95, such as 0.9; 1.54, any of the foregoing compositions, wherein 30% of the aqueous slurry of the dioxide dioxide abrasive has a PCR of from 78 to 94, such as from 82 to 90, or 86. 1.55 Any of the foregoing compositions, wherein 30% is oxidized; the aqueous slurry of δ 磨 abrasive has an RDA of from 100 to 124, such as 106 to 118, or 112; 1.56 of any of the foregoing compositions, wherein 3% of the cerium oxide abrasive The aqueous slurry has a PCR/RDA ratio of 0.6 to 0.9, such as 0.7 to 0.8, such as 0.77; 1.57 composition 1. 〇, wherein the SiO 2 abrasive has a claw to iiym, such as (but not limited to) 9μηι to 13μπι, 8μιη The median particle size to 12μηι, or 8μιη to Ιίμιη. 1.58 Any of the compositions 1.9 to 112 in which the number of particles in the niobium oxide abrasive is reduced by 16% to 20% after application to the hard surface in the oral cavity. The use of the cerium oxide compound as the abrasive of the present invention may be amorphous dioxin = shixi, estuary oxidized second, or amorphous precipitated oxidized dream. In a specific example, the dioxin fraction f consists of the cerium oxide compound described herein. The dioxic abrasives described herein can be used as a cleansing agent, a dental grind 201041599, a light agent, and/or an anti-sensitizer. An additional aspect of the invention relates to the surprising discovery that broken cerium oxide abrasive particles can help treat tooth sensitivity because broken particles can block tubule occlusion. In addition, it has been surprisingly found that smaller particles are more effective in removing debris and stains from cracks in the mouth, particularly the interdental surfaces of the teeth. The invention also includes a method 2.0, a method for improving oral health, comprising applying an effective amount of an oral composition of any specific example of 1.0 to 1.55 to an oral cavity of a patient in need thereof, such as a method 1. Reduce or inhibit caries formation, 2. Reduce, repair or inhibit enamel pre-crack damage, such as by quantifying photoinduced fluorescence (QLF) or conductance measurement (ECM) detection, 3. reducing or inhibiting tooth demineralization And promote tooth remineralization, 4 · reduce tooth hypersensitivity, 5. reduce or inhibit gingivitis, 6. inhibit microbial biofilm formation in the mouth, 7. reduce plaque accumulation, and / or 8. clean teeth And the mouth. Other embodiments of the invention will be apparent to those skilled in the art. DETAILED DESCRIPTION OF THE INVENTION As used herein, all measurement levels described herein are based on the total composition weight, unless otherwise indicated. In addition, all references cited herein are hereby incorporated by reference in their entirety. However, there is any conflict between the definitions of 201041599 and the definitions in the cited references. As used herein, "safe and effective amount" means a sufficient amount to treat the oral cavity (e.g., to reduce plaque, gingivitis, and/or smear) in a tissue and structure that does not harm the oral cavity. As used herein, "orally acceptable carrier" means a material or a plurality of materials which are used in the oral cavity in a safe and effective manner for applying the composition of the present invention. As used herein, "clean" generally refers to the removal of contaminants, dust, impurities, and/or foreign matter from the target surface. For example, in the context of an oral surface where the surface is tooth enamel, cleansing can remove at least some of the film or stain' such as plaque biofilm, film or calculus. As used herein, "polishing" generally refers to a finishing or scouring process that results in a smoother and/or more glossy surface. Polishing and cleansing can also provide a bright surface with smudge removal, such as whitening of the tooth surface. In various embodiments, an oral composition having an abrasive is provided. Preferably, the cerium oxide abrasive is a precipitated amorphous cerium oxide compound. The present invention may have an average particle diameter of from 5 μm to 205 μm. The average particle size of the particles can be measured by any means known in the art. For example, the average particle size can be measured using a Malvern Particle Size Analyzer, Model Mastersizer S » Malvern Instruments, Inc. (Southborough > Massachusetts, USA), wherein the xenon-krypton gas laser beam is projected through a transparent material containing abrasive suspended in an aqueous solution. Transparent cell. The light ray scattered by the particles passes through an angle that is inversely proportional to the particle size. The light 4 detector array measures the amount of light at several predetermined angles. The electrical signal proportional to the measured luminous flux value is then processed by a microcomputer system to determine the particle size distribution of the subject abrasive from 12 201041599 following the scattering pattern predicted by the theoretical particles defined by the refractive index of the sample and the aqueous dispersion. The average particle size considers the skewed particle size and the size distribution of the particles. As used herein, d1() refers to a population of particles having a 10% diameter limit (i.e., 10% of the population is equal to or less than the value of the hawthorn). It has been surprisingly found that when the oral composition is brushed against a hard tooth surface such as a tooth or enamel, the abrasive particles incorporated into the oral composition are broken or broken. It has also been surprisingly found that when the oral composition is applied to the soft surface of the oral cavity or soft biofilm (e.g., film or plaque), the abrasive particles incorporated into the oral composition substantially retain their original dimensions. The ceria abrasive of the present invention may have a specific oil absorption of from 60 cc/l to 120 cc/100 g of linseed oil. In one embodiment, the cerium oxide abrasive has an oil absorption of from 70 cc/100 g to 110 cc/100 g. In one embodiment, the cerium oxide abrasive has an oil absorption of from 80 cc / 100 g to 100 cc / 100 g. In one embodiment, the bismuth telluride abrasive has an oil absorption of from 40 cc/100 g to 60 cc/100 g. The amount of oil absorbed can be determined by various means known to those skilled in the art. For example, the oil absorption can be determined by the absorption per 100 grams of linseed oil or dibutyl phthalate (DBP) or abrasive. The oil absorption value can be measured using ASTM Rub-Out Method D281. The abrasive of the present invention can have a specific Einlehner hardness of 4 to 11. The Einlehner hardness can be determined by various means known to those skilled in the art. For example, the 'Einlehner At-1000 Abrader can measure the hardness of abrasive particles in the following manner: Weighing and exposing the Fourdrinier metal mesh (ie copper or brass) to the abrasive suspension (eg 10% abrasive) Suspension 13 201041599 liquid) acts for a given number of revolutions. The hardness value is expressed as the weight loss per kilogram of the number of revolutions (eg, 100,000 revolutions) of the long wire machine. In the present invention, the Einlehner hardness of the cerium oxide abrasive used in the present invention is determined by using a brass mesh. 100 g of cerium oxide was added to 1 liter of water to rotate the slurry to 100,000 or 174,000 revolutions. The abrasive component of the present invention can be administered to the care product at a level of from 1% by weight to 95% by weight. The amount of abrasive present depends on the particular form of the oral care composition. For example, when the oral care composition is a toothpaste or gel, it may contain from 1% to 75% of the abrasive. When the oral care composition is a dental powder, it may contain from 50% to 95% of the abrasive. PCR is a method known to those skilled in the art to measure the efficacy of removing tooth stains relative to the standard. The PCR value referred to herein is modified by "In vitro"

Removal of Stain wkh Dentifrice, G. κ. St〇〇key et al., j Dental Research, 61 '123-9 (1982). Modifications The PCR methods used herein are described in U.S. Patent Nos. 5,658,553 and 5,651,958, both to each of the entireties. In this modification, the clear film material is first applied to the bovine teeth and then stained with the combination of the film material and tea, coffee, and FeCl3, while in the original method described by Stookey et al., both the film and the stain Apply at the same time. The composition of the present invention may have a PCr of from 8 Å to 1 Å. In one embodiment, the 'PCR' is 85 to 100. In another aspect, the PCR is from 90 to 95. The compositions of the present invention may have an RDA value of less than 15 Å, such as from 90 to 130, from 100 to 120, from 1 to 5 to 115. The RDA value can be determined by any number of methods known to those skilled in the art. For example, the RDA value can be determined in accordance with the methods proposed in U.S. Patent Nos. 14, 2010, 4,599, 4, 340, 583, 4, 420, 312 and 4, 421, 527, and Hefferren, Journal of Dental Research, July-August 1976, p. 563-573. Usually, the radiated 32P tooth system is brushed with, for example, an oral composition. The quality of the teeth removed from the brushed dentin was quantified by the 32p analysis observed in the abrasive slurry. The amount of dentin wear is based on a standard composition that is brushed on the tooth, typically calcium pyrophosphate, which has an RDA of 100. Typically, less abrasive compositions have lower RDA values. The compositions of the invention may have a PCR/RDA ratio of 0.5 to 1.5. In one embodiment, the PCR/RDA ratio can be 5.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, or 1.5. The PCR/RDA ratio is used to determine the relative dosing of the cleansing and wear characteristics of oral care compositions such as dentifrice or toothpaste compositions. A useful ceria abrasive material for preparing the oral compositions of the present invention is available from Davison Chemical Division of W. R. Grace & C (Baltimore ' Maryland] USA under the trade name GRACE VP5. In one embodiment, the cerium oxide is INEOS (now pQ c〇rp)

Sorbosil AC43 dioxide dioxide. In a specific example, Ac43 dioxide has the following properties, including but not limited to an average particle size of 27 to 4 μm (determined by MALVERN MASTERSIZER), a screening residue of + 45 μm, and a humidity loss at 105 ° C. It is 8.0% maximum, at 1 〇〇〇t: the ignition loss is 14.0% maximum, and the pH in the aqueous suspension is 5 5 to 7.5. * Other abrasives may also be utilized in the present compositions, but it is contemplated that the compositions of the present invention may contain a single cerium oxide abrasive compound as previously described, and may generally have no other bismuth or bismuth telluride abrasives and compounds. Orally acceptable is well known in the art and may contain surfactants, humectants, extenders, foaming agents, ionized ion sources, flavorings, colorants, chelating agents, polymers, enzymes, water, actives And other substances. The oral cavity composition can be further stepped to include the fineness of the tanning material. The particular composition depends on the intended use of the composition. The carrier can be in the liquid phase, semi-solid phase, or solid phase. Π The composition can be tooth powder (including toothpaste, tooth powder, and prevent paste), candy (including glue, beads and η and chew), film, paint gel (paint_on), or familiar with the use of abrasives Any other form known. The choice of a particular carrier component depends on the desired product form. The active ingredient contains, for example, an antibacterial active agent, an anticalculus agent, an anticonvulsant, an anti-inflammatory agent, an anti-sensitivity agent, an enzyme, a nutrient, and the like. An active substance useful herein is a human or lower animal patient which is active enough to have a therapeutically or prophylactically effective amount, without undue adverse effects (eg, toxicity, irritability, or Allergic reactions), when used in the methods of the invention, are commensurate with a reasonable risk/benefit ratio, as the case may be, in the compositions of the invention. The specific and effective amount of active substance will vary depending on the particular condition being treated, the condition of the patient, the nature of the concurrent treatment (if any), the particular active used, the summer form of the ampoule, the carrier used, and The desired dose (d〇sage regjmen) varies. There are those discussed in U.S. Patent Publication No. 2003/0206874, which is incorporated herein by reference. The actives of the present invention are also discussed in U.S. Patent No. 6,290,933 to Durga et al., and U.S. Patent No. 6,685,92, the disclosure of the disclosure of the disclosure of the disclosure of U.S. Patent No. 6,685,92, the fluoride salt and the fluoride ion source (e.g., the soluble fluoride salt). It is well known in the art and can be combined into a towel. Representative fluoride ion sources include, but are not limited to, vaporized tin (8), gasified sodium, potassium fluoride nano, sodium fluorite, fluorescein, amine fluoride, ammonium fluoride, and combinations thereof. In several embodiments, the fluoride ion source comprises (10) tin (8), sodium fluoride, amine fluoride, mono-synonym, and mixtures thereof. In some embodiments, the limulus composition of the present invention may also contain a source of fluorinated material or a fluorine-providing component in an amount sufficient to supply 25 ppm to 5,00 ppm of fluoride ion, usually at least 50 ppm, Such as 5 〇〇 to 2 〇〇〇 ppm, such as 1 〇〇〇 to 1600 ppm, such as 1450 ppm. The fluoride ion source may be added to the composition of the invention in a level of G.G1 wt% to 1 G weight #% in one embodiment or in a range of 0.03 wt% to 5% by weight in another embodiment, and in another In a particular example, the composition is present in a level of from 0.1% by weight to 5% by weight; however, it is to be understood that the weight of the fluoride salt providing the appropriate level of fluoride ion will vary significantly depending on the relative ion weight in the salt, and the skilled artisan can quickly decide This amount. The oral compositions of the present invention may comprise one or more agents to add to the amount of foam produced when the mouth is brushed. Such blowing agents are known to those skilled in the art. Illustrative examples of agents that increase the amount of foam include, but are not limited to, polyoxyethylene and several polymers including, but not limited to, alginate polymers. Polyoxyethylene can increase the amount of foam and foam thickness produced by the oral care vehicle component of the present invention. Polyoxyethylene is also generally known as polyethylene glycol ("PEG") or polyethylene oxide. The polyoxyethylene suitable for the present invention will have a molecular weight of 200,000 to 7, 〇〇〇, 〇〇〇. : In a specific example, the molecular weight will be 600,000 to 2, 〇〇〇, 000, and in another specific example, 800, ι to ιοοο, οοο. The amount of polyoxyethylene present may be 17 201041599 1 reset % to % by weight 'in one embodiment 5% by weight to 5% by weight and in another embodiment 10% to 2 〇 by weight of the present invention for oral use Nursing group money oral care _ ingredients. The foaming agent dose (i.e., single dose) in the oral (iv) care composition is from 1 to 9 weight percent, from 5 to 0.5 weight percent, and in another embodiment from 2 to 2 weight percent. The compositions of the present invention may also incorporate - or a variety of interfacial agents known in the art. Suitable surfactants include those that are reasonably stable throughout the broad range, such as anionic, cation, hetero or zwitterionic binders. For example, U.S. Patent No. 3,959,458 to Agric, et al., U.S. Patent No. 3,937,8, to Haefele, and (10) U.S. Patent No. 4,051,234 to et al. And the like is incorporated herein by reference. In certain embodiments, the anionic surfactant useful herein comprises a water soluble salt of an alkyl sulfate having from 1 to 18 carbon atoms in the alkyl group and a sulfonated monoglyceride having a fatty acid having from 1 to 18 carbon atoms. Water soluble salt. Examples of anionic surfactants of this type are sodium lauryl sulfate, sodium lauryl sarcosinate and sodium coconut monoglyceride sulfonate. Mixtures of anionic surfactants can also be utilized. In another specific example, a cationic surfactant useful in the present invention can be broadly defined as a derivative of an aliphatic quaternary ammonium compound having a long alkyl chain having from 8 to 18 carbon atoms, such as gasified lauryl tris. Mercaptoammonium, gasified cetylpyridine, cetyltrimethylammonium bromide, diisobutylphenoxyethyldimylbenzylammonium hydride, coconut alkyltrimethylammonium nitrite, fluoride a mixture of cetyl pyridyl, and ^. The cation-surfactant is described in U.S. Patent No. 3,535,421, the entire disclosure of which is incorporated herein by reference. A number of cationic surfactants can also be used as a bactericide for the composition. In the present invention, an embodiment of the invention, the oral composition is substantially free of cationic surfactants. Description of the Compositions of the Invention The nonionic surfactant can be broadly defined as a compound produced by the condensation of an alkylene oxide (essentially hydrophilic) with an organic hydrophobic compound which can be an essential aliphatic or alkyl aromatic. Examples of suitable nonionic surfactants include, but are not limited to, Pluronics, polyethylene oxide condensates of alkyl phenols, products derived from the condensation of ethylene oxide with a reaction product of propylene oxide and ethylenediamine, A cyclic alcoholic condensate of an aliphatic alcohol, a long-chain tertiary amine oxide, a Q long-chain secondary phosphine oxide, a long-chain dialkyl hydrazine, and a mixture of such materials. In several embodiments, a zwitterionic synthetic surfactant useful in the present invention can be broadly defined as a derivative of an aliphatic quaternary ammonium, squama, and sulfonium compound, wherein the aliphatic group can be straight or branched and An aliphatic substituent containing 8 to 18 carbon atoms and a surfactant containing a sinophilic water-based group such as silk, a hetero salt, a Wei salt, and a hybrid 2 are illustrated in the composition package 2 = 〇 Base, sodium sulphate, laurel sulphate _, coconut reduction test = sorbitol ester 20, and combinations thereof. V-clamps are not alkali and poly. The composition of the present invention may include a handyman w, nano. Surfactant or compatible interface activity = cresyl sulphate weight % to 3 liters by weight and in the specific example 〇 3% by weight of the total composition. In the example, 5% by weight to 2. 〇 The composition of the present invention may also contain a flavoring agent. The seasonings used in the practice of the present invention are known to those skilled in the art. Various flavorings, cools, alcohols, and the like include, but are not limited to, essential oils and the like. Examples of essential oils include spearmint oil, 201041599 peppermint oil, wintergreen oil, sassafras oil, clove oil, sage oil, eucalyptus oil, marjoram oil, cinnamon oil, lemon oil, lime oil, grapefruit oil, and orange oil. . Also used are chemicals such as menthol, fragrant celery, and fennel. Peppermint oil and spearmint oil are used in several specific examples. The flavoring agent is incorporated into the oral composition at a concentration of 0.1 to 5% by weight and 0.5 to 1.5% by weight. The dosage of the flavoring agent in the dosage of the individual oral care composition (i.e., a single dose) is from 0.001 to 0.05% by weight and in another embodiment from 0.005 to 0.015% by weight. The oral care compositions of the present invention may also optionally contain one or more chelating agents which are capable of being found in the bacterial cell wall. In combination with this I bow, the cell wall of the bacteria is weakened and the bacterial lysis is expanded. Another group that may be present in the chelating agents of the present invention is soluble pyrophosphate. The pyrophosphate used in the present composition may be any alkali metal pyrophosphate. In a number of specific examples, the salt comprises a tetra alkali metal pyroester, a dimetal bis-acid caustic acid salt, a tri-metal monocarboxylic acid pyro-acid salt, and mixtures thereof, wherein the alkali metal is sodium or potassium. Salts are used in both hydrated and unhydrated forms. An effective amount of pyrophosphate salt for use in the present composition is generally sufficient to provide at least 1.0% by weight pyrophosphate ion, 1.5% to 6% by weight, and 3.5% to 6% by weight of the ion. The oral composition of the present invention optionally also comprises one or more polymers, such as polyethylene glycol, polyvinyl mercaptoether maleic acid copolymer, polysaccharides (such as cellulose derivatives, such as renegade groups). Cellulose, or poly-gel, such as Sanxian gum or carrageenan. The acidic polymer (e.g., polyacrylate gel) can be provided in the form of a free acid or a partially or fully neutralized water-soluble alkali metal (e.g., potassium and sodium) or ammonium salt. Several specific examples include 1:4 to 4: 1 maleic anhydride or a copolymer of an acid and another polymerizable ethylenically unsaturated monomer, for example, having a fraction of 20 201041599 (MW) 30,0〇〇 to 丨, 〇〇〇, 〇〇〇 曱 乙烯基 vinyl ether (methoxyethylene). Such copolymers are available, for example, as GantrezAN 139 (M.W. 500,000), AN 119 (M.W. 250,000) and S_97 medical grade (M.W. 70,000) of GAF Chemicals Corporation. Other operating polymers include, for example, maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrrolidone (N-vinyl-2-pyr〇liidone), or ethylene (the latter For example, Monsanto EMA No. 11〇3, MW 10,000 and EMA Grade 61) 1:1 of the copolymer, and acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutyl A vinyl ether or a ruthenium-vinyl-2-pyrrolidine with a 1:1 copolymer. Suitable as a polymerized dilute or ethylenic unsaturated taurine containing activated carbon to a carbon-hydrocarbon double bond and at least one enemy group, that is, an acid containing an olefinic double bond, the olefin double bond is rapidly polymerized. The role is due to the presence of a monomeric molecule at the alpha-beta position relative to the carboxyl group or as a partial sulfhydryl end group. The description of the acid is acrylic acid, mercaptoacrylic acid, ethacrylic acid, α_chloroacrylic acid, crotonic acid, β-acryloxypropionic acid, sorbic acid, α-chlorosorbic acid, Q cinnamic acid, β-styrylacrylic acid, Muconic acid, itaconic acid, 彳nukangic acid, Zhongkang 酉文, 戊细一酸, aconitic acid, α-phenyl acrylic acid, 2-mercapto acrylic acid, 2-cyclohexyl acrylic acid, leucovoric acid, Acid, fumaric acid, maleic acid and anhydride. Other different olefin monomers copolymerizable with the carboxylic acid monomer include vinyl acetate, vinyl chloride, dinonyl maleate, and the like. The copolymer contains a carboxylate group which is sufficient for water solubility. Further classified polymeric agents comprise a composition of a homopolymer comprising a substituted acrylamide and/or an unsaturated sulfonic acid and a salt thereof, wherein the polymer is selected from the group consisting of having a molecular weight of from 1000 to 2,000,000. The propylene sulfhydryl alkane sulfonic acid (e.g., 2 propylene amide 2 methyl propyl 21 201041599 succinic acid) is an unsaturated sulfonic acid, and is described in U.S. Patent No. 4,842,847, issued to Zahid on June 27, 1989, and This article is incorporated by reference. In the preparation of oral care compositions, it is sometimes necessary to add a plurality of thickening materials to provide the desired consistency or to stabilize or enhance the properties of the formulation. In a number of specific examples, 'thickeners are carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose, and water-soluble salts of cellulose ethers (eg, sodium carboxymethyl cellulose and carboxymethyl hydroxyethyl fibers). Sodium). Natural gums such as karaya gum, gum arabic, and tragacanth can also be combined. Colloidal magnesium aluminum silicate or finely divided cerium oxide can be used as a component of the thickening composition to further improve the constituent materials. In some specific examples, the thickener is used in an amount of from 0.5% by weight to 5.0% by weight of the total composition. The oral care compositions of the present invention may also optionally comprise one or more enzymes. Useful enzymes include any available protease, glucan hydrolase, endoglycosidase, phosphatase, mutanase, lipase and mucin or a compatible mixture thereof. In several embodiments, the enzyme is a protease, a polyglucosidase, a endoglycosidase, and a dextran allosteric hydrolase. In another embodiment, the enzyme is a mixture of papain, endoglycosidase or polyglucosidase and a dextran allosteric enzyme. Additional enzymes suitable for use in the present invention are disclosed in U.S. Patent No. 5,000,939, U.S. Patent No. 4,992,420, U.S. Patent No. 4,355,022, U.S. Patent No. 4,154,815, U.S. Patent No. 4,058,595, U.S. Patent No. 3, 991, 177, and U.S. Patent No. 3,696, 191, incorporated herein by reference. The enzyme of a mixture of several compatible enzymes in the present invention constitutes 0.002% to 2.0% in one specific example, or 〇〇5% to 1.5% in another specific example, or 〇1% to 〇5% in another- Specific 22 in the 201041599 instance. Water may also be present in the oral compositions of the present invention. The water used for the composition for the cavity should be deionized and free of _f. The water generally compensates for the difference in composition and comprises from 10% to 90% by weight, from 2% by weight to 6% by weight or from 10% to 30% by weight of the oral composition. This amount of water is added to the free water added by other materials (such as sorbitol or any of the ingredients of the present invention). in

The money of the present invention may also include _#丨, such as preventing the shark from being hardened when exposed to the gas. A number of guarantees can also be expected to have a sweet flavor. The _wet agent is mainly used as a specific weight% to 7 〇% by weight or in another embodiment, %% by weight and 65 % by weight of the tooth powder composition. Suitable for containment of food polyols such as glycerin, sorbitol, wood propylene, propylene glycol and other polyols and mixtures of such sterility agents. A mixture of glycerin and mountain (iv) may be used as a humectant component of the toothpaste composition herein in a number of specific examples. The compositions of the present invention may also comprise - or a plurality of antimicrobial agents. Antibacterial agents are known in the art and include phytonic acid, sodium benzylate, potassium citrate, boric acid, and phenolic compounds such as betanaphthol, clariparin, thyme, scented brain, barley, Fragrant buds, menthol, age, pentance, hexidine, hexamethylene hexafluoride, chlorinated lauryl, chlorinated nutmeg-based bite, green tea-based pyridin. Bismuth, gasified cetyl pyridine, cetyl bromide, and halogenated diphenyl hydrazine (eg, trigas). The compositions of the present invention may also comprise one or more test amine acids such as arginine in the form of a free base or salt. The reagent may be added in an effective amount such as 丨% by weight to 2% by weight (based on the total weight of the composition 23 201041599). The composition of the present invention may be combined with potassium mono- or potassium polyphosphate, potassium hydrogencarbonate, chlorination reagents such as potassium salts such as cloves; pin salt; salt; chloride salt and potassium oxalate, · pepper test; The reagent is added in an effective amount such as i by weight, and the reagent may be added depending on the weight. The invention relates to the composition of the present invention. The composition of the present invention can also be used for treating the composition of the present invention, and can also include the composition known in the art. It is suitable for whitening and bleaching. The material contains peroxidation i = salt, over-salt. Weed contains four compounds and peroxides of organic soil, organic peroxy compounds, peroxyacid wind and their mixtures. The product contains peroxygen, peroxidation, sodium peroxide, magnesium peroxide, peroxide dance, barium peroxide, and potted characters. Other peroxides contain perborate, urea peroxide, and potted characters. Suitable metal chlorites may include chlorite dance, bismuth chlorite, sulphur acid acid, sulphuric acid clock, chlorous acid, and potassium sulfite. The reagent may be in an effective amount depending on the reagent selected. Adding, for example, from 1% by weight to 20% by weight based on the total weight of the composition. In addition to the above ingredients, the specific examples of the present invention may contain a plurality of variable dental powders as described below. The optional ingredients include, for example, but not limited to, ) Wei agent, soaping agent, flavoring agent Sweeteners, additional anti-plaque agents, abrasives, and colorants. This and other optional ingredients are further described in U.S. Patent No. 5,004,597 to Maj eti, US Patent No. 3,959,458 to Agricola et al., and Haefele. U.S. Patent No. 3,937,8, 7. 24 201041599 The choice of abrasive for the oral composition can be interpreted as pure type, fine product (particle size), particle size distribution and abrasive dosage to ensure that the tooth enamel is positive. ^ Cannot be excessively wiped off during use of the composition 'but fully cleansed and/or polished. In the context of oral care, the efficacy of the abrasive can be expressed according to the cleanliness or wear criteria of the tooth powder' ie the thin and difficult ratio (PCR) Or radioactive dentin wear (RDA). Methods of performing PCR and RDA are known in the art, as described in U.S. Patent Nos. 5,939,051 and 6,290,933. In several specific examples, the composition is safe for humans or other animals in the oral cavity. Any of the oral or cosmetically acceptable abrasives that meet the above requirements can be selected for use in the oral compositions. Additional abrasives can also be included in the compositions of the present invention. Containing aluminum oxide (calcined emulsified imitation), Shixiazao soil, pumice stone, sauerkraut 'cuttieb〇ne', insoluble acid salt, composite resin (such as melamine resin, bismuth resin, and urea _ 曱Aldehyde resin), polycarbonate, boron carbide, microcrystalline wax, microcrystalline cellulose (including a combination of colloidal microcrystalline cellulose and carboxymethyl cellulose), and combinations and derivatives thereof. In the insoluble phosphate, Useful abrasives are orthophosphate, polymetaphosphate and pyrophosphate. Examples are dicalcium phosphate dihydrate, diammonium dihydrate dihydrate, calcium hydrogen phosphate, calcium pyrophosphate, beta-calcium pyrophosphate, tricalcium phosphate, Metaphosphoric acid, potassium metabolite, and sodium metaphosphate. In several embodiments, the oral composition is in the form of a dentifrice and the exemplary carrier is substantially semi-solid or solid. The carrier can be aqueous, that is, including from 5% to 95% water. In other embodiments, the carrier is substantially non-aqueous. Carriers include, for example, oral active ingredients, surfactants (e.g., surfactants, emulsifiers, and suds modifiers), viscosity modifiers and thickening 25 201041599 agents, humectants, diluents, fillers, additional pH modifiers, colorants, preservatives, solvents, and combinations thereof. It is to be understood that although the general attributes of the various materials of the above categories may vary, there may be a number of common attributes and any given material may be supplied for multiple purposes within two or more of that type of material. As will be appreciated by those skilled in the art, in addition to the materials previously described, the oral compositions will optionally contain other materials including, for example, softeners, emollients, mouthfethes, and the like. Examples of a suitable carrier for the composition of the oral cavity are discussed in U.S. Patent No. 6,669,929 to Boyd et al., U.S. Patent No. 6,379,654 to Gebreselassie et al., and U.S. Patent No. 4,894,220 to Nabi et al. The oral composition optionally includes one or more anti-stone compositions as described in U.S. Patent No. 5,292,526 to Gaffar et al. In various embodiments, the anti-calculus composition comprises one or more polyphosphates. The anti-calculus composition may comprise at least one alkali metal or ammonium tripolylate or hexametaphosphate which is wholly or partially neutralized in the oral composition in an amount effective to resist stone. The anticalculus active may also comprise at least one water soluble, linear, molecularly dehydrated polyphosphate salt in an amount effective to resist stones. The anticalculus active may also comprise a mixture of potassium and sodium salts, at least one of which is present as a polyphosphate anticalculus in the presence of an effective anticalculus. The anticalculus active agent may also contain a linear molecular dehydrated polyphosphate anticalculus agent in the presence of an effective anti-stone amount in the presence of a mixture of sodium and potassium salts. The ratio of potassium to sodium in the composition can be as high as less than 3:1. The polyphosphate may be present in the oral composition in various amounts, for example, in a weight ratio ranging from polyphosphate ion to antibacterial agent in a range from more than 0.72:1 to less than 4:1' or an antibacterial enhancer and polyphosphoric acid. The weight ratio of the root ion ranges from 1:6 to 2.7: 1, or the weight of the antimicrobial enhancer to the polyphosphate 26 201041599 The ratio of the ratio ranges from 1:6 to 2.7··1. Other useful anticalculus agents include polyglycol polymers and polyvinyl methyl/simene (PVM/μα) copolymers such as GANTREZ®. Another active agent useful in the dentifrice composition of the present invention is an antibacterial agent which may be present in an amount of from 0.001 to 3.0% by weight of the oral composition. A non-limiting form of useful oral oral care compound comprising a nonionic antimicrobial comprising phenol and a bisphenol compound such as a halogenated diphenyl ether comprising triclosan (24 4, _ trichloro-2'-jing- Diphenyl test), triclocarban (3 4 4_ two gas average · one gland '3,4,4_tricliloroC3Tb3iiili<le), and 2 · oxo _ ethanol, benzyl ester, and two Carbanilide. The dentated diphenyl ether (e.g., trigas) can be present, for example, in an amount of 0.3% by weight of the oral composition. Suitable for surfactants that are reasonably stable throughout a wide pH range. Such compounds are well known in the art and include non-soap anions (such as sodium lauryl sulfate (SLS), N-carnitine and N-palmitoyl sarcosine), nonionic (eg, polysorbate) Polysorbate 20 (polyoxyethylene 20 sorbitan monolaurate 'TWEEN820) and polysorbate 80 (polyoxyethylene 2 sorbitan monooleate 'TWEEN® 80 ), P〇l〇 Xamer 407, available from BASF Corporation under the trade name PLURONIC® FI27), cationic, zwitterionic (eg cocoamidopropyl beet and lauryl propyl beet) and amphoteric organic synthetic cleaners. Examples of suitable surfactants for use in oral compositions are discussed in, for example, U.S. Patent No. 4,894,220 to Nabi et al., U.S. Patent No. 6,555,094 to Glandorf et al., and U.S. Patent No. 6,706,256 to Lawlor et al. In various embodiments, 27 201041599 one or more surfactants are present in the oral compositions of the present invention in a range of from 0.001% to 5% or from 5% to 25%. · As the case for oral compositions, thickeners include natural and synthetic and colloidal substances, such as carrageenan (Irish red algae), Sanxian gum, carboxy; sodium vegan, starch, polyvinylpyrrole _, hydroxyethyl Propyl propyl cellulose, butyl butyl fluorenyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose. In each of the specific examples, the thickener is present in the dentifrice composition in an amount of from 1 to 1% by weight or from 5 to 4% by weight. The orally acceptable dental powder carrier medium for the preparation of the dentifrice composition, the carrier vehicle, optionally includes a humectant. The humectant may be glycerin, 'sorbitol, and xylitol, propylene glycol having a molecular weight ranging from 2 Å to 0,0 戋, other humectants, and mixtures thereof. The humectant concentration typically amounts to 5 to 2% by weight of the oral composition. Water is typically present in an amount of at least 丨〇% by weight and typically from 25 to 70% by weight of the oral composition. 〇 〇 synthetic anionic linear polycarboxylates are efficacy enhancers, which are optionally used as oral ribs having several active ingredients (including anti-g agents, anti-calculus agents or other active agents in oral compositions (4)). The merging vinegar is usually used in the form of a water-soluble alkali metal (e.g., preferably sodium) or an ammonium salt which is self-reducing, or partially or completely. The terms "synthesis" and "straight line exclusion include carboxymethyl cellulose and other derivatives of cellulose and natural gums ^ known thickeners or gelling agents, nor are they due to cross-linking to reduce the solubility of carbopol (carbopol) The good copolymer of the car is 1:4 to 4: 1 cis butyl dianhydride or a copolymer of an acid and another polymerizable ethylenically unsaturated monomer, preferably having a molecular weight (mW) 28 201041599 30,000 to 1 , 〇〇〇, 〇〇〇 曱 乙烯基 vinyl ether (methoxy ethene). A useful conjugate is methyl ethyl ketone / butyl butyl sinensis. Examples of such copolymers from ISP Corporation Available under the trade name GANTREZ®. When present, anionic polycarboxylates are used in an amount effective to achieve the desired efficacy of any antibacterial, anticalculus or other active agent in the dentifrice composition. In various embodiments The synthetic anionic polycarboxylate contained in the oral composition is present in an oral composition of 0.001 to 5% or 0.1 to 2.0%. Q The oral composition of the present invention can be obtained by any of the techniques known in the art. Methods The components are combined to produce an oral care composition. The method of using the system proposed in the Example as described in Martin et al.'S U.S. Patent Nos 6,4〇3, 〇59; clinical Pharmacology for Dental Professionals (Mosby-Year Book,

Inc., 3rd edition 1989), Mosby's Dental Hygiene: Concepts, Cases and Competencies (Daniel, S. and Harfst, S. eds., Elsevier Science Health Science Div. 2002); and Ernest W. Flick, Cosmetic and Toiletry Formulations ,Version 2. ◎ The present invention provides a method and process for using the oral compositions of the present invention to clean and/or polish the oral surface. Further, the oral composition can be treated and inhibited as appropriate, for example, stomatous symptoms, dental plaque, and dental calculus oral compositions can be applied to the patient in any suitable manner known in the art; for example, by using a suitable coating The applicator or delivery device, such as a brush, a toothed strip, a membrane 'main shooter, a tape, a pill, or any other applicator or transfer garment known in the art', guides the sigma cavity composition to the patient's mouth. The composition can be used in preventive methods and procedures to promote and maintain oral health, appearance, and overall health. The oral composition can be applied to the patient according to the special treatment schedule. The soil is also applied to the patient. 29 201041599 Treatment and / or inhibition of stains, plaque, stones or calculus pain preparation: Storage: Table of operating instructions can provide products in commercial packaging Under the theory, it is believed that the composition of the invention has an initial average particle size. When the oral composition of the present invention is used for brushing soft tissues, such as to remove plaque or film, the silica stone is sufficient, such as removing the soft surface from the tooth surface. Thus, the oral composition initially has the same PCR. However, when the oxidized abrasive particles contact the hard tooth surface (e.g., dentine or enamel), they break into smaller particles; thereby resulting in a low RDA. Therefore, when the composition of the present invention is used for treating the oral cavity, the soft tissue has been peeled off: and the hard tissue is prevented from being worn. It is believed that when the composition is used in the mouth, PCR and/or RDA can reduce both values over time due to the reduced size of the cerium oxide abrasive. The resulting broken ceria particles resulting from contact with a hard surface also give an unexpected advantage; that is, the ability to polish the surface of the tooth and/or block the dental tubule, resulting in cleaner teeth and/or reduced tooth sensitivity. . Thus, the compositions of the present invention result in improved cleansing, polishing, and reduced tooth sensitivity. The invention is further illustrated by the following non-limiting examples. [Embodiment] Example 1 The characteristics of cerium oxide A and cerium oxide B are determined as follows. The oxidation of A is Grace VP5. The dream of oxidizing B is ZEODENT® 105 J 30 201041599 from J.M. Huber (Havre de Grace, Maryland, USA). The conditions for the Einhlemer test are to make the fossils in the face of mL for 120 minutes. The measurement system is presented in Table 1.匕石夕 A Oil absorption (cc/1 OOg ) ^Al〇〇 average particle size (μηι) 9 to 13 di〇( μηι) * '------- 2.74 Brass Einlehner hardness ------ 6 to 9 ------- Ceria 50 to 65 8 to 12 2.58 12 to 18 Ο Less than the size of the value. One called the granules with ... = deionized water to prepare 10,000 w / w polyliquid with dioxobic AAB. The particle size distribution of the dare slurry is determined as follows: _ analysis Hydr 〇 2_S small volume automatic sample dispersion unit. The slurry was spun in the water bath for 1 minute before the measurement, and any master was smashed. Use the platform Ο 20ml (sidewal〇7〇〇W x 3%) to make the soft square head bristle brush (head size about length x width 2.8cmx l.〇cm) mounted along the whole Cui Lu The trough base is moved. The weight is added to the head of the brush head P (250 g) to create a positive force during the brushing process. The brushing machine runs at a rate of 100 doublings per minute along the aluminum surface for a total of 3 strokes. After brushing, the slurry was removed from the cell substrate and sonicated for 15 minutes. The sample was loaded into a Malvern 2000 particle size analyzer. The cerium oxide abrasive particle size was then determined and presented in Table 2. Table 2 31

The combination of the two gasification 矽A will be determined by the method described in the previous ten. The PCR and RDA values of the wide liquid were determined by the method of first cerium oxide slurry, 10%, 15%, 20% and 30% w/w. The PCR and RDA values are shown in Table 3 by the previous descriptions of this article.

PCR RDA

Example 3

PCR/RDA

15% VP5 20% VP5 30% VP5 76 84 86 95 93 112 0.80 0.90 0.77

According to Table 4, a dentifrice region such as a toothpaste was prepared.

32 201041599 Water 29 29 37.1 37.1 PEG 3 3 SLS 1.5 1.5 1.5 1.5 Cellulose gum 0.6 0.6 0.8 0.8 Sodium pyrophosphate 0.5 0.5 Norty acid aminopropyl sweet test 0.4 0.4 Tri-gas 0.3 0.3 Sodium sulfate 0.3 0.3 0.1 0.1 Glycerin 19.9 19.9 Titanium Dioxide 0.1 0.1 Fluoride Nano-0.2 0.2 0.3 0.3 PVMA/MA Copolymer 2 2 Carrageenan 0.3 0.3 __Seasoning and Coloring Agent----- 1.5 1.5 2.1 2.1 Example 4

给予 Give toothpaste MF-A or MF-B to two groups of 30 people who are sensitive to teeth, and instruct them to use the composition as their sole tooth powder for one month according to their normal brushing habits. At the end of the month, 75% of people brushed with MF_A reported reduced tooth sensitivity, and 1% of people brushed with MF_B reported reduced tooth sensitivity. At the end of the month, 3% of people brushed with MF-A reported increased tooth sensitivity, and 15% of people brushed with MF_B reported increased tooth sensitivity. ~ Example 5 For two groups of 50 people, toothpaste WD_A or wd_B was given, and the composition was used as its sole tooth powder for one month according to the normal brushing habits such as 33 201041599. 80% of people who brushed their teeth with WD-Α reported that they observed a whitening/buffing effect, while 5% of people who brushed their teeth with WD-B reported that they observed a whitening/buffing effect. Example 6 To two groups of 15 smokers (average 1.4 packs per day), toothpaste MF_A or MF-B was administered, and the composition was used as its sole tooth powder according to its normal brushing habit. At the end of the month, 85% of people who brushed their teeth with MF-A noticed a decrease in their stains, and 12% of those who brushed their teeth with MF-B noticed a decrease in their stains. Example 7 The RDA and PCR values of two compositions comprising 20% cerium oxide A and 20% cerium oxide B were determined by the methods previously described herein. The two compositions are essentially identical except for the different cerium oxide abrasives. The results are presented in Table 5. Table 5 Bu 20% cerium oxide a 20% Dioxane: ~ RDA 112 207 PCR 93 ~~~-^ 103 PCR/RDA 0.83 —-~~~ 0.5 [Simple diagram description] No [Main component symbol description] None 34

Claims (1)

201041599 VII. Patent Application Range: 1. An oral composition comprising an orally acceptable ruthenium-doped and cerium oxide abrasive comprising an average particle size of from 5 μm to 20 μm and from 4 to 11 The Einlehner Hardness Dioxide Dream Compound. 2. The composition of claim 1, wherein the silica stone has an average particle size of from 8 μm to 11 μm. Ο 3. The composition of claim 2 or 2, wherein the cerium oxide abrasive has an oil absorption of from 60 cc/100 g to I20 cc/100 g. 4. The composition of any of the preceding claims, wherein the cerium oxide abrasive has a brass mniehner hardness of 5 to 1 Torr at 174,000 revolutions. A composition according to any one of the preceding claims, which has a film clean ratio of . 6. The composition of any of the preceding claims, which has a radioactive tooth wear of less than (9). 7. The PCR/RDA ratio of the composition of any of the preceding claims. </ RTI> </ RTI> </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; &quot;-Emulsified Shixi 9. As the above-mentioned towel, please consult the composition of any of the patent scope, the abrasive has a mountain of 0 is 2.5μιη^ 29um, and the second emulsion is 〇1〇. ^ Domain material ^ When the product is applied to the hard surface of the oral cavity, #中中的用用组11. When the composition is used, the dimethyl die-cut surface is made into particles of H 2010 in the cavity of 2010 35 35 201041599 2.6 μπι. 12. The composition of any of the preceding claims, wherein the oral composition is brushed on the teeth for at least 3 seconds to 5 minutes. 13. The composition of any of the preceding claims, wherein after application to a hard surface in the oral cavity, the average particle size of the cerium oxide abrasive is reduced by 16% to, for example, % 0. 14. A composition according to any one of the preceding claims, wherein the cerium oxide abrasive has a di 〇 reduction of 9% to 12% after application to a hard surface in the oral cavity. 2. The composition of any of the preceding claims, including a fluoride ion source comprising: selected from the group consisting of tin (II) fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, and fluoroquinone Sodium fluoride, ammonium fluoroantimonate, amine fluoride, ammonium fluoride fluoride, and combinations thereof. 16. The composition of any of the preceding claims, comprising at least one surfactant selected from the group consisting of sodium lauryl sulfate, cocoamidopropyl betaine, and combinations thereof. A composition according to any one of the preceding claims, which comprises at least one humectant selected from the group consisting of glycerin, sorbitol and combinations thereof. 18. The composition of any of the preceding claims, comprising at least one polymer selected from the group consisting of polyethylene glycol, polyvinyl methyl ether butyl butyric acid copolymer, polysaccharides, and combinations thereof . The composition according to any one of the preceding claims, which comprises a diphenyl domain selected from halogenated, an herbal extract or an essential oil, a biguanide preservative, a quaternary compound, a variegated preservative, Haeksi An antibacterial agent for hexetidine, povidone iodine, delmopinol, salifluor, 36 201041599 metal ion, blood root test, honeycomb gelatin, and oxidant (4) Hong (10)-a (4). 20. A composition according to any one of the claims, which comprises a tooth desensitizer. 21. A composition according to any of the preceding claims, which comprises a tooth whitening compound. A composition according to any one of the preceding claims, which is a toothpaste or a gel. 23. The composition according to any one of the preceding claims, which comprises applying a slurry of 1 to 5 ml of the oral composition onto a surface of 1 to 1 cm 2 ; contacting the surface with teeth irradiated by P; The tooth surface is brushed for 300 strokes at a constant force of 2 to 5 Newtons, wherein each stroke causes the surface to move to the tooth to 〇cm2; and the method of measuring the RDA value. 24. The composition of any of the preceding claims, wherein the RDA of the oral composition for 5 seconds in the oral cavity is 1.2 to 1.6 times the RDA of the same composition for 1 to 5 minutes in the oral cavity. 25. The composition of any of the preceding claims, wherein the Einlehner hardness is 174 and the turns are measured on a brass mesh. 26. The composition of any one of claims 1 to 25, wherein the Einlehner hardness is measured by a brass mesh per ι〇〇. 27. The composition of any of the preceding claims, wherein the 10% aqueous slurry consisting of the cerium oxide abrasive has a PCR of from 65 to 80. The composition of any of the preceding claims, wherein the 10% aqueous slurry consisting of cerium oxide abrasive has an RDA of from 75 to 91. 37 201041599 29. The composition of the monthly patents, which consists of the sulphur dioxide and the RDA, has a PCR/RDA ratio of 〇7 to 〇9. 30. - The genus of the genus - includes an orally acceptable surface and a cerium dioxide cerium abrasive, the cerium dioxide cerium abrasive comprising a composition selected from the group consisting of 8 μm to 11 μm, 9 to 13 μm, 8 μm to 12 μm, and 8 μm to 11 μm The median particle size of the group, and the Einlehner hardness of the cerium oxide compound of 4 to 11. The composition according to any one of claims 1 to 12, wherein the number of particles in the nitric oxide cerium abrasive is reduced by 16% to 20% after being applied to a hard surface in the oral cavity. A method for improving oral health, which comprises applying an effective amount of the oral composition of any one of claims 1 to 22 to an oral cavity of a patient in need thereof. 38 201041599 IV. Designation of representative drawings: (1) The representative representative of the case is: (No). (2) A brief description of the symbol of the representative figure: None 5. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: None