200948334 九、發明說明： 【發明所屬之技術領域】 本發明係有關一m 儲存方法，尤指-種可二4片取樣f料的儲存系統及 系統及儲存方法。 強化醫療f料管理存的錯存 【先前技術】 ❿ ❹ 管理，醫療資訊之數位化及其高致能 資料由醫生將患者資\#勢不可稽。傳統上病患的醫療 料、耸彳呼/ 不於實體的文件上（如病歷資 才二X光片專)，既占用儲存空間，又耗費人力、： 系料料庫方式進行醫療資料的 二、、、g . ^網路科技的資料傳輸將使整個醫療資料 更有效的移轉與運用，對於病患的醫療的服務品質 /、醫1的醫事管理上產生了極明顯的進步與效率。 、此外，面療衫像在臨床診斷應用上的需求日漸增加， 雖Ί恨夕i療儀器提供了數位化之醫療資料，但仍然有許 多=料未依數位化標準格式儲存。因此標準格式的數位醫 療=貝料在不同醫院資訊系統間的交換是必要的，其將有助 於醫療資源的使用，及有效提升醫療工作放率。而dicom (Digital Imaging and Communications in Medicine) 私準是現今普遍使用的醫療影像交換標準，它提供了波形 資訊物件定義，以使各醫療單位之數位醫療影像有共同之 影像標準，得以相互交換傳輸。 同時，醫療院所、學校、護理、保養機構等，捨電子 顯微鏡而以傳統光學顯微鏡做為顯微觀察之工具，仍極為 200948334 普遍。醫師、護理人員要求病患就身體局部 成病理切片再使用光學顯微鏡進行細微觀察、檢驗你，製 必要。 甘杈驗便有其 而〃將'、且織影像放大倍率後，如缺乏影 #、倍數等，聯佐證資訊，便成為無意義的圖素目：座 還原原始狀錢為可理解的組織影像資訊。、‘、、、法 【發明内容】 φ /有鉍於此，本發明提供一種病理切片取樣資粗ό/ι =統及儲存方法，其係在病理㈣上攝取數、=存 數电❹傻同供f 織衫像與同倍放大之原影像（許 数，'且織心像R倍較大聽織影像後的影 i倍 以取得倍數組織影像在原組織影像中對應=丁，， 調閱組織影像時，可以明確知道倍數組織影像在^供^ 像的位置，而快速的進行組織的雜。 I且織影200948334 IX. INSTRUCTIONS: [Technical Field] The present invention relates to a m storage method, and more particularly to a storage system and system and storage method for a sample of four samples. Strengthening the misunderstanding of medical care management [Previous technology] ❿ ❹ Management, digitalization of medical information and its high-energy data. The doctors will be patient. Traditionally, the medical materials of the patients, the screaming/not on the physical documents (such as the medical record and the second X-ray film), both occupying the storage space and manpower, , , , g. ^ Network technology data transmission will make the entire medical data more effective transfer and use, for the patient's medical service quality / medical management of medical 1 has made significant progress and efficiency. In addition, there is an increasing demand for facial spectacles in clinical diagnostic applications. Although the hate ceremonies provide digital medical information, there are still many products that are not stored in the standard format. Therefore, the standard format of digital medical treatment = exchange of bacon in different hospital information systems is necessary, which will help the use of medical resources and effectively improve the medical work rate. Dicom (Digital Imaging and Communications in Medicine) is a commonly used medical image exchange standard. It provides a definition of waveform information objects, so that digital medical images of medical units have common image standards and can be exchanged and transmitted. At the same time, medical institutions, schools, nursing and maintenance institutions, etc., using electron microscopy and traditional optical microscopy as a tool for microscopic observation are still extremely popular in 200948334. Physicians and nursing staff ask the patient to take a pathological section of the body and then use an optical microscope to observe and test you carefully. After the Ganzi test, there will be a ' 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 News. , ',,, method [invention] φ / 铋 , , , , , , , , φ φ 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理 病理The same as the original image for the f-shirt image and the same magnification (many, 'and the weaving heart image R times larger than the shadow image after the image is multiplied to obtain the multiple tissue image in the original tissue image corresponding = D,, read the organization When the image is displayed, it is possible to clearly know the position of the multiple-imaged image at the position of the image, and to quickly organize the miscellaneous.
本發明的病理切片取樣資料的儲存方法，A 切片上攝取一原組織影像，铁後 病理 右盥抽W α 原組織影像上選取〜 tit (Reg10n of Interesting ; R〇i) , 有興趣區塊，以取得一倍數組織影像。 μ _影像與同倍放大之原影像，再將同倍放大之 ^组織影像對照便可取得倍數組織影像對應在原 中的影像座標，接著，將倍數組織影像與對應二傻= 整合成一切片取樣資料，最後將切片 柢本二上松 以提供醫師_。 片取樣貝枓儲存起來， 根據前述，本發明的病理切片取樣資料 攝像顯微鏡比對$ 200948334 置、一整合梦胃 理切片攝取〜 儲存裝置。其中，攝像顯微鏡從一病 ❹ 參 如I，以取得^紐織影像，並且放大該原組織影像上的一 鏡，用織影像。比對裝置祕於攝像顯微 倍數組織影像織影像與同倍放大之原影像，以取得 置祕於比對=在原組織影像中的一影像座標。整合裝 為-切片取樣=，用以整合倍數組織影像與影像座標成 該切片取樣賢^。儲存裝置轉接於整合裝置，用以儲存 方法^=片取樣資料的儲存系統及儲存 對運算，以取織影像與同倍放大之原影像的比 像座標位置彡像對應在原組織影像上的影 整合起來，以像與所對應的影像座標 ‘影像時’醫師僅需透、㈣如此’在醫師調閱組織 ==影像在原組織影像的相對= 的對組織作判斷，以強化醫療品質。 、㈣逮 以土的概述與接下來的詳細說明皆為示範 了進一步說明本發明的令請專利範 2疋為 他目的與優點，將在後續的說明與圖示加以間述。χ明的其 【實施方式】 、 為本發明的方法流程示意圖。首先第四】以 鏡]0，再將從病人身體上所取得的病理攝微 像光學顯微鏡10的觀測台上（s]〇〇)，二⑶放置在攝 為人體組織切片或血液、細菌、穢物^ ^病理切片20 穢物寺病理組織取樣f成 200948334 ==議察的試片。然後，在病理切片20上選取- 塊22以成A亚且使用攝像光學顯微鏡1〇攝取該觀察區 :2上選t原組織影像23(_。接下來，從原組織 心像23上選取一有興趣區塊（R〇i) Μ 所需放大倍率放大$” ； 再根據 _)。棍掳!^ Γ 進而取得倍數組織影像24 、 返，第一圖揭露有1倍數组織影像24。 ❹ ❹ 倍數將原組織影像23依據前述 組織影像t Λ 原縣27_)。在此，係將原 將所卿1 1倍成為同倍放大之原影像27。然後， (又侍數組織影像24利用軟體程式以ζ型掃聪方式 27，進^1由上而下的掃瞎）比對成為同倍放大之原影像 影像=同倍放大之原影像27 f找出舆1倍數組織 定是〗拉^似的影像的座標C〇 (SU〇) ’並將此座標C0設 ⑶。。組織影像24對應在原組織影像23的影像座標 取另，著·’再次執行步驟Sl〇4，以從原組織影像23上選 異柄4#有興趣區塊（R0i) 21_2與有興趣區塊（R01) 21-3。 “ί所需放大倍率分別放大R(H 2卜2及_ 21-3，進 露得倍數組織影像25、26(S106)。根據上述，第一圖揭 路10倍數組織影像25與20倍數組織影像26。 1〇 参考第一圖，接下來，將原組織影像23依據前述 然°與20倍數放大成為同倍放大之原影像27(S108)。 ’相同地，將所獲得10倍數組織影像25利用軟體 =以Z型掃瞄方式比對同倍放大之原影像27 (放大10 ‘:原:且織影像23)，進而在同倍放大之原影像27中找出 /、 倍數組織影像25近似的影像的座標Cl (S110)，並 200948334 將此座標Cl設定是10倍數組織影像25對應在放大10倍 的原組織影像23的影像座標C1。相同地，將所獲得20倍 數組織影像2 6再次利用軟體程式以Z塑掃瞄方式比對同倍 放大之原影像27(放大20倍的原組織影像23)’進而在同 倍放大之原影像27中找出與20倍數組織影像26近似的影 像的座標C2 (S110)，並將此座標C2設定是20倍數組織 影像26對應在放大20倍的原組織影像23的影像座標C2。 如此，透過前述的方式，即可以產生各種倍數組織影 ❹ 像24、25、26各自對應在原組織影像23的影像座標c〇、 Cl、C2。 復參考第一圖，將1倍數組織影像24、10倍數組練 影像25、20倍數組織影像26分別與原組織影像烈比對 後’係可以得到各自對應在原組織影像23的影像座標⑶、 ❹ a、C2。接下來，將含有各自的影像座標c〇、a、C2的各 倍數組織影像24’、25’、26,連同病患姓名、性別、病 歷號碼、影像名稱及放大倍率等資訊，以轉換成為mc〇M 標準格式的-切R樣資料D1 (S112)。最後，再將d腿 標準格式的切片取樣資料照麗縮或不壓縮處理，再儲 存於-儲存裝Ϊ 16 t (S1U) ’以提供閱。 復參考第-圖’當醫師要調閱儲存在儲存 的^取樣資料，僅需根據病理切片2()的特: ^姓名、病歷號、…等查詢條件，進行簡單檢 f入⑽G)，即可以從儲存裝置16中_出，理^ 2〇對應的切片取樣資料D1。而所調閱出的切片：樣:: D1經轉換、解壓縮程序後，得以 ^取樣貝科 C0、Π、C2的各倍數組織影像24，、25，的衫像座標 ' 26 、病患姓 200948334 ί師影像名稱及放大倍率等資峨02) c 名、性別、病歷號$ ^ 25 、26 、病患姓 確的知道各種倍數大倍率等資訊，以明 的相對位置（S2〇4)，' 4、25、26在原組織影像23 ❹ 品質。同時，醫郇也可以對作判斷’以強化醫療 整、瀏覽等操作。 士别迷各種的資訊進行編輯、調 配合第一圖，炎老—_ 片取樣資料的儲存圖。第二圖為本發明的病理切 攝像光學顯微鏡I、’一比對儲存系統1包括有-儲存裝置16。苴办 ^衣置12、一整合裝置14及一 2。上攝取一原組攝像先學顯微鏡10從病理切片 一謝，並對該_ =好亚=原組織影㈣上選出 置12利用軟體 予賴鏡10,比對襄 24 >25 >26 π 孓知目田方式將各倍數組織影i 進而在原27進行比對運i 26近似的影像的“中找出。各倍數組織影像24、25、 C2 ； 2C52 5 CO . ci , 23的影像座標co'…C2。整人原級織影像 裳置U整合所獲得的裳置 沉與其影像騎GQ、Π、G =數= 物象24、25、 ，號瑪、影像名稱及放大倍率等“ 性別、病 標準格式的切片取樣H ° ^換成為DIc〇m 照壓縮或不_處理後，即被儲存在= 10 200948334 的儲S:，其令刪置16為，庫。 的切片取樣資師要T儲存在儲存裝置16中 繼對:二，:可=裝 參 資料D1經轉換，片樣資料 而所調閱出的切片取揭 換、解壓縮程序後，得以產生病理切Λ樣 =雜23、各種倍數組織影像=片， 影像座標CO、C]、ΓΟ ^々 與各自的 名稱及放大样漆站、病心姓名、性別、病歷號碼、 織影像24、，以使醫師明確的知道各種倍數 1 速對病徵作_，，進而快 前述:種資訊進行編輯、調整、以作*也可以對 儲存=所^利理切片取樣資料的館存系繞及 27的比對運管，㈣倍數_影像朗倍放大之原影像 上的影像座‘置，應在·織影像 像座標整合起來，以織影像舆所對應的影 時’醫師僅需=索=: 庫:::=r織影像及座標 陳現在榮幕書面上；it i目關位置用清楚易懂的方式 像’ 1而快速的診斷病情，以強化醫療品質。解的對⑽ 才文以上所述，僅為本發明最佳呈每 之魏内’可輕易思及之變化或修飾，皆可涵蓋在以下本 200948334 案之專利範圍。 【圖式簡單說明】 ' 第一圖為本發明病理切片取樣資料的儲存方法流程 示意圖； 弟二圖為本發明的病理切片取樣資料的儲存糸統方 塊示意圖； ’ 第三圖為本發明的方法流程示意圖；及 @ 第四圖為本發明另一方法流程示意圖。 【主要元件符號說明】 . 本發明： 儲存系統1 攝像光學顯微鏡10 比對裝置12 整合裝置14 儲存裝置16 ❹ 切片取樣貧料D1 病理切片20 有興趣區塊21-1、21-2、21-3 原組織影像23 1倍數組織影像24 10倍數組織影像25 20倍數組織影像26 影像座標CO、Cl、C2 含有影像座標的倍數組織影像24’ 、25’ 、26’ 12 200948334 同倍放大之原影像27 終端電腦3 0 〇 ❹ 13In the method for storing pathological slice sampling data of the present invention, a raw tissue image is taken on the A slice, and the post-iron pathology right sputum W 原 original tissue image is selected to be ~ tit (Reg10n of Interesting; R〇i), an interesting block, To achieve multiples to organize images. The μ _ image and the original image of the same magnification, and then the same magnification image of the tissue image can be obtained to obtain the image coordinates corresponding to the original tissue image in the original, and then the multiple tissue image and the corresponding two silly = integrated one slice Sampling the data, and finally the sliced sputum is loosened to provide the physician. The sample was sampled and stored, and according to the foregoing, the pathological slice sampling data of the present invention was compared with the imaging microscope for $200948334, and an integrated dream stomach slice was taken up to the storage device. Among them, the camera microscope takes a disease from the sputum to obtain the image of the woven fabric, and enlarges a mirror on the original tissue image, and uses the woven image. The comparison device is secretive to the imaging microscopy. The multiple images of the tissue image and the original image of the same magnification are obtained to obtain a secret image comparison = an image coordinate in the original tissue image. The integrated device is - sliced sample = used to integrate the multiple tissue images and image coordinates into the slice sampling. The storage device is transferred to the integrated device for storing the storage system and the storage pair operation of the method for sampling the data, and the image coordinate position image of the original image of the same image is corresponding to the image of the original tissue image. Integration, in the image coordinates of the corresponding image when the 'doctors only need to transparent, (4) so in the doctor's access to the organization == image in the original tissue image relative = the judgment of the organization to strengthen medical quality. (4) The summary of the soil and the detailed descriptions of the following are exemplary. The purpose of the invention is further illustrated in the following description. [Embodiment] The present invention is a schematic flowchart of the method of the present invention. First, the fourth] with the mirror] 0, and then the pathological microscopy obtained from the patient's body, the optical microscope 10 on the observation stage (s] 〇〇), two (3) placed in the human tissue slices or blood, bacteria,秽物^^Pathological section 20 Sputum temple pathological tissue sampling f into 200948334 == the test piece. Then, on the pathological section 20, the block 22 is selected to be A sub-area and the observation area is taken up using a camera optical microscope 1 : 2 the original tissue image 23 is selected (_. Next, one is selected from the original tissue image 23 Interest block (R〇i) Μ The required magnification is magnified by $”; then according to _). The stick 掳!^ Γ and then the multiple tissue image 24, back, the first figure reveals a multiple of the tissue image 24. ❹ ❹ The multiple of the original tissue image 23 is based on the aforementioned tissue image t Λ原县27_). Here, the original image 1 is doubled to the original image 27 of the same magnification. Then, the number of the organization image 24 utilizes the software program. ζ 扫 扫 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 27 The coordinates of the image C〇(SU〇)' and the coordinates C0 are set to (3). The tissue image 24 corresponds to the image coordinates of the original tissue image 23, and the image is again executed step S1 to 4 from the original tissue image 23 Select the different handles 4# interested block (R0i) 21_2 and the interested block (R01) 21-3. The rates are respectively magnified by R (H 2 卜 2 and _ 21-3, and the multiple-folded tissue images 25, 26 (S106) are obtained. According to the above, the first figure reveals 10 times the number of tissue images 25 and 20 times the number of tissue images 26. 1〇 Referring to the first figure, next, the original tissue image 23 is enlarged to the original image 27 of the same magnification according to the foregoing and 20 magnifications. (S108). Similarly, the obtained 10 times the tissue image 25 is obtained by using software = Z. The scanning mode compares the original image 27 of the same magnification (magnifying 10 ': original: and weaving image 23), and then finds the coordinate Cl of the image similar to /, the multiple of the tissue image 25 in the original image 27 of the same magnification. (S110), and 200948334, the coordinate C1 is set to 10 times the tissue image 25 corresponding to the image coordinate C1 of the original tissue image 23 magnified 10 times. Similarly, the obtained 20-fold tissue image 26 is again utilized by the software program Z. The plastic scanning method compares the original image 27 of the same magnification (the original tissue image 23 magnified 20 times), and then finds the coordinate C2 of the image similar to the 20-fold tissue image 26 in the original image 27 of the same magnification (S110). ), and set this coordinate C2 to be 20 times the number of tissue images 26 corresponds to The image coordinates C2 of the original tissue image 23 are 20 times larger. Thus, the image coordinates c〇, Cl, and C2 corresponding to the original tissue image 23 of the various multiple images 24, 25, and 26 can be generated by the above-described methods. Referring to the first figure, the image coordinates (3) of the original tissue image 23 can be obtained by comparing the image of the 1st number of tissue images 24, 10 times the array of the image 25 and the 20 times of the tissue image 26 with the original tissue image. a, C2. Next, the multiple-folded tissue images 24', 25', and 26 containing the respective image coordinates c〇, a, and C2, together with the patient's name, gender, medical record number, image name, and magnification, are converted into mc. 〇M Standard format - Cut R sample data D1 (S112). Finally, the sliced sample data of the standard format of the d-leg is processed or not compressed, and then stored in the storage device 16 t (S1U) ’ for reading. Refer to the figure-picture 'When the physician wants to access the stored sample data, only need to check the condition of the pathological slice 2 (): ^ name, medical record number, etc., and simply check the input (10) G), ie The slice sampling data D1 corresponding to the slice can be extracted from the storage device 16. The slice that was read: Sample: After D1 was converted and decompressed, it was able to sample the multiples of the Becco C0, Π, C2, and the image of the image 24, 25, the figure of the shirt '26, the patient's surname 200948334 ίImage name and magnification, etc. 02) c name, gender, medical record number $ ^ 25 , 26 , the patient's last name knows the various multiples of large magnification and other information, to the relative position (S2 〇 4), ' 4, 25, 26 in the original tissue image 23 品质 quality. At the same time, doctors can also make judgments to strengthen medical treatment and browsing. Don't be fascinated by the various information to edit, adjust and match the first picture, the old - _ sample storage data. The second figure is a pathological imaging optical microscope I of the present invention, and an alignment storage system 1 includes a storage device 16.衣 衣 衣 12, an integrated device 14 and a 2. Take a group of cameras to learn the microscope 10 from the pathological section, and thank the _ = good Asia = original tissue shadow (four) on the 12 to use the software to the ray mirror 10, the comparison 襄 24 > 25 > 26 π孓 目 方式 将 将 将 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 孓 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出 找出'...C2. The whole person's original woven image is set to U-integrated to get the sun and its image riding GQ, Π, G = number = object 24, 25, 玛, image name and magnification, etc. "Sex, disease The standard format slice sampling H ° ^ is changed to DIc〇m. After compression or not _ processing, it is stored in the storage S: = 10 200948334, which causes the deletion of 16 as the library. The slice sampling capitalist needs to store the T in the storage device 16 to relay the pair: Second, the data can be generated after the sliced data is converted and the decompressed program is read. Cut sample = miscellaneous 23, various multiple tissue images = film, image coordinates CO, C], ΓΟ ^ 々 with their respective names and magnified paint station, heart name, gender, medical record number, woven image 24, so that The doctor clearly knows that the various multiples of the first speed are used as the _, and then the above: the information is edited, adjusted, and used as * can also be compared with the storage of the stored data. Transportation management, (4) multiple image _ image 朗 magnifying the image on the original image 'set, should be integrated in the woven image image coordinates, to match the shadow of the image ' doctor only need = cable =: library:: :=r weaving image and coordinates Chen is now on the written screen; it i position to clear the disease in a clear and easy-to-understand way like '1 to strengthen medical quality. (10) The above is only the preferred embodiment of the present invention, which can be easily changed or modified, and can be covered in the following patents of this 200948334 patent. [Simplified illustration of the schema] 'The first figure is a schematic flow chart of the storage method of the pathological slice sampling data of the present invention; the second figure is a schematic diagram of the storage system of the pathological slice sampling data of the present invention; 'The third figure is the method of the present invention Schematic diagram of the flow; and @ The fourth diagram is a schematic flow chart of another method of the present invention. [Main component symbol description] The present invention: storage system 1 imaging optical microscope 10 comparison device 12 integration device 14 storage device 16 切片 slice sampling poor material D1 pathological slice 20 interested blocks 21-1, 21-2, 21- 3 original tissue image 23 1 multiple tissue image 24 10 multiple tissue image 25 20 multiple tissue image 26 image coordinate CO, Cl, C2 multiple image image with image coordinates 24', 25', 26' 12 200948334 same as the original image 27 terminal computer 3 0 〇❹ 13