TW200846358A - HtrA1-PDZ and HtrA3-PDZ modulators - Google Patents
HtrA1-PDZ and HtrA3-PDZ modulators Download PDFInfo
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- TW200846358A TW200846358A TW097105456A TW97105456A TW200846358A TW 200846358 A TW200846358 A TW 200846358A TW 097105456 A TW097105456 A TW 097105456A TW 97105456 A TW97105456 A TW 97105456A TW 200846358 A TW200846358 A TW 200846358A
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- pdz domain
- polypeptide
- htral
- htra3
- amino acid
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Digital Transmission Methods That Use Modulated Carrier Waves (AREA)
- Gyroscopes (AREA)
- Compression, Expansion, Code Conversion, And Decoders (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89042807P | 2007-02-16 | 2007-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200846358A true TW200846358A (en) | 2008-12-01 |
Family
ID=39590928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097105456A TW200846358A (en) | 2007-02-16 | 2008-02-15 | HtrA1-PDZ and HtrA3-PDZ modulators |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2111413A2 (es) |
| AR (1) | AR065370A1 (es) |
| CL (1) | CL2008000493A1 (es) |
| PE (1) | PE20081795A1 (es) |
| TW (1) | TW200846358A (es) |
| WO (1) | WO2008101160A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| EP1994155B2 (en) | 2006-02-13 | 2022-05-04 | Daiichi Sankyo Company, Limited | Polynucleotide and polypeptide sequences involved in the process of bone remodeling |
| HUE039133T2 (hu) | 2011-10-14 | 2018-12-28 | Hoffmann La Roche | Anti-HtrA1 antitestek és felhasználási módszerek |
| EP2875051B1 (en) | 2012-07-19 | 2019-02-20 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibodies |
| EP3368578B1 (en) | 2015-10-30 | 2021-03-17 | H. Hoffnabb-La Roche Ag | Anti-htra1 antibodies and methods of use thereof |
| HK1257565A1 (zh) | 2016-03-04 | 2019-10-25 | 豪夫迈‧罗氏有限公司 | 作为htra1抑制剂的新型三氟甲基丙酰胺衍生物 |
| CN108699105A (zh) * | 2016-03-04 | 2018-10-23 | 豪夫迈·罗氏有限公司 | 作为htra1抑制剂的新型二氟酮酰胺衍生物 |
| CN109415330A (zh) | 2016-07-18 | 2019-03-01 | 豪夫迈·罗氏有限公司 | 作为htra1抑制剂的新型二氟酮酰胺衍生物 |
| JP2019526564A (ja) | 2016-08-23 | 2019-09-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Htra1阻害剤としての新規なトリフルオロメチルプロパンアミド誘導体 |
| WO2018036942A1 (en) | 2016-08-23 | 2018-03-01 | F. Hoffmann-La Roche Ag | New difluoroketamide derivatives as htra1 inhibitors |
| EP3625243B1 (en) | 2017-05-12 | 2023-10-18 | Universität Duisburg-Essen | Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors |
| US20220033450A1 (en) * | 2018-10-22 | 2022-02-03 | University Of Copenhagen | Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof |
| CN115362001A (zh) * | 2020-03-06 | 2022-11-18 | 哥本哈根大学 | Pick1的脂质缀合的肽抑制剂 |
| CN120591277B (zh) * | 2025-08-08 | 2025-12-05 | 山东省农业科学院家禽研究所(山东省无特定病原鸡研究中心) | 调控htra1基因表达的生物材料及在抗病毒中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090087878A9 (en) * | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
-
2008
- 2008-02-15 WO PCT/US2008/054081 patent/WO2008101160A2/en not_active Ceased
- 2008-02-15 EP EP08729968A patent/EP2111413A2/en not_active Withdrawn
- 2008-02-15 AR ARP080100656A patent/AR065370A1/es unknown
- 2008-02-15 TW TW097105456A patent/TW200846358A/zh unknown
- 2008-02-15 CL CL200800493A patent/CL2008000493A1/es unknown
- 2008-02-15 PE PE2008000341A patent/PE20081795A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20081795A1 (es) | 2009-01-08 |
| AR065370A1 (es) | 2009-06-03 |
| CL2008000493A1 (es) | 2008-06-27 |
| EP2111413A2 (en) | 2009-10-28 |
| WO2008101160A3 (en) | 2009-02-19 |
| WO2008101160A2 (en) | 2008-08-21 |
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