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TW200846358A - HtrA1-PDZ and HtrA3-PDZ modulators - Google Patents

HtrA1-PDZ and HtrA3-PDZ modulators Download PDF

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Publication number
TW200846358A
TW200846358A TW097105456A TW97105456A TW200846358A TW 200846358 A TW200846358 A TW 200846358A TW 097105456 A TW097105456 A TW 097105456A TW 97105456 A TW97105456 A TW 97105456A TW 200846358 A TW200846358 A TW 200846358A
Authority
TW
Taiwan
Prior art keywords
pdz domain
polypeptide
htral
htra3
amino acid
Prior art date
Application number
TW097105456A
Other languages
English (en)
Chinese (zh)
Inventor
Brent A Appleton
Steven T Runyon
Sachdev S Sidhu
Nicholas J Skelton
Christian Wiesmann
Yingnan Zhang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of TW200846358A publication Critical patent/TW200846358A/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Digital Transmission Methods That Use Modulated Carrier Waves (AREA)
  • Gyroscopes (AREA)
  • Compression, Expansion, Code Conversion, And Decoders (AREA)
TW097105456A 2007-02-16 2008-02-15 HtrA1-PDZ and HtrA3-PDZ modulators TW200846358A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89042807P 2007-02-16 2007-02-16

Publications (1)

Publication Number Publication Date
TW200846358A true TW200846358A (en) 2008-12-01

Family

ID=39590928

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097105456A TW200846358A (en) 2007-02-16 2008-02-15 HtrA1-PDZ and HtrA3-PDZ modulators

Country Status (6)

Country Link
EP (1) EP2111413A2 (es)
AR (1) AR065370A1 (es)
CL (1) CL2008000493A1 (es)
PE (1) PE20081795A1 (es)
TW (1) TW200846358A (es)
WO (1) WO2008101160A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
EP1994155B2 (en) 2006-02-13 2022-05-04 Daiichi Sankyo Company, Limited Polynucleotide and polypeptide sequences involved in the process of bone remodeling
HUE039133T2 (hu) 2011-10-14 2018-12-28 Hoffmann La Roche Anti-HtrA1 antitestek és felhasználási módszerek
EP2875051B1 (en) 2012-07-19 2019-02-20 Daiichi Sankyo Company, Limited Anti-siglec-15 antibodies
EP3368578B1 (en) 2015-10-30 2021-03-17 H. Hoffnabb-La Roche Ag Anti-htra1 antibodies and methods of use thereof
HK1257565A1 (zh) 2016-03-04 2019-10-25 豪夫迈‧罗氏有限公司 作为htra1抑制剂的新型三氟甲基丙酰胺衍生物
CN108699105A (zh) * 2016-03-04 2018-10-23 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型二氟酮酰胺衍生物
CN109415330A (zh) 2016-07-18 2019-03-01 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型二氟酮酰胺衍生物
JP2019526564A (ja) 2016-08-23 2019-09-19 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Htra1阻害剤としての新規なトリフルオロメチルプロパンアミド誘導体
WO2018036942A1 (en) 2016-08-23 2018-03-01 F. Hoffmann-La Roche Ag New difluoroketamide derivatives as htra1 inhibitors
EP3625243B1 (en) 2017-05-12 2023-10-18 Universität Duisburg-Essen Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors
US20220033450A1 (en) * 2018-10-22 2022-02-03 University Of Copenhagen Virally expressed inhibitors of pdz domains, such as pick1 and uses thereof
CN115362001A (zh) * 2020-03-06 2022-11-18 哥本哈根大学 Pick1的脂质缀合的肽抑制剂
CN120591277B (zh) * 2025-08-08 2025-12-05 山东省农业科学院家禽研究所(山东省无特定病原鸡研究中心) 调控htra1基因表达的生物材料及在抗病毒中的应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants

Also Published As

Publication number Publication date
PE20081795A1 (es) 2009-01-08
AR065370A1 (es) 2009-06-03
CL2008000493A1 (es) 2008-06-27
EP2111413A2 (en) 2009-10-28
WO2008101160A3 (en) 2009-02-19
WO2008101160A2 (en) 2008-08-21

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