TW200833844A - Lung cancer-targeted peptides and applications thereof - Google Patents
Lung cancer-targeted peptides and applications thereofInfo
- Publication number
- TW200833844A TW200833844A TW96119332A TW96119332A TW200833844A TW 200833844 A TW200833844 A TW 200833844A TW 96119332 A TW96119332 A TW 96119332A TW 96119332 A TW96119332 A TW 96119332A TW 200833844 A TW200833844 A TW 200833844A
- Authority
- TW
- Taiwan
- Prior art keywords
- lung cancer
- peptides
- phage
- applications
- xenografts
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 206010058467 Lung neoplasm malignant Diseases 0.000 title abstract 4
- 201000005202 lung cancer Diseases 0.000 title abstract 4
- 208000020816 lung neoplasm Diseases 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 abstract 1
- 238000011579 SCID mouse model Methods 0.000 abstract 1
- 206010070863 Toxicity to various agents Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 229960004679 doxorubicin Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 238000002823 phage display Methods 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 abstract 1
- 229960002066 vinorelbine Drugs 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target lung cancer and were identified by phage display. Targeting phage PC5-2 and synthetic peptide SP5-2 were both able to recognize human pulmonary tumor specimens from lung cancer patients. In SCID mice bearing NSCLC xenografts, the targeting phage was able to target tumor masses specifically. When the peptide was coupled to liposomes containing the anti-cancer drugs vinorelbine or doxorubicin, the efficacy of these drugs against human lung cancer xenografts was improved, the survival rate increased, and the drug toxicity was reduced.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90097307P | 2007-02-13 | 2007-02-13 | |
| US11/783,927 US8415453B2 (en) | 2007-02-13 | 2007-04-13 | Lung cancer-targeted peptides and applications thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200833844A true TW200833844A (en) | 2008-08-16 |
Family
ID=44819247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW96119332A TW200833844A (en) | 2007-02-13 | 2007-05-30 | Lung cancer-targeted peptides and applications thereof |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW200833844A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI578999B (en) * | 2015-01-16 | 2017-04-21 | 中央研究院 | Lung cancer specific peptides for targeted drug delivery and molecular imaging |
| WO2018103064A1 (en) * | 2016-12-09 | 2018-06-14 | Agricultural Technology Research Institute | Cancer stem cell targeting peptide and use thereof |
-
2007
- 2007-05-30 TW TW96119332A patent/TW200833844A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI578999B (en) * | 2015-01-16 | 2017-04-21 | 中央研究院 | Lung cancer specific peptides for targeted drug delivery and molecular imaging |
| WO2018103064A1 (en) * | 2016-12-09 | 2018-06-14 | Agricultural Technology Research Institute | Cancer stem cell targeting peptide and use thereof |
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