TW200826950A - Antimicrobial articles and method of manufacture - Google Patents

Abstract

Antimicrobial articles and methods for the manufacture of such articles are provided.

Description

200826950 IX. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to antimicrobial articles comprising silver and to methods of making such articles. [Prior Art] Although skin wounds heal more effectively in a humid environment, the risk of bacterial infection increases in the presence of moisture. In addition, bacteria can form resistance to antibiotics and ultimately render antibiotics ineffective. Silver compounds are known to impart a surface (e. g., wound tissue) to the antimicrobial effect with minimal risk of bacterial resistance. For example, in a humid environment of a wound bed, silver is delivered by continuously releasing silver ions into the wound. It has been reported in the literature that in the absence of stabilizers, silver salts coated on cotton or other substrates do not maintain color stability once exposed to ultraviolet ("uv") light or visible light. However, the stabilizer also reduces the solubility of the silver salt, which also inhibits the release of silver ions. If the silver ion release is too low (less than 0.01 mg/g in water within 30 minutes), its antimicrobial effect will also be reduced and it will no longer be effective for wound treatment. It is desirable to provide color stable antimicrobial articles and methods of making such articles, wherein such articles provide antimicrobial activity when used as a wound dressing or the like. SUMMARY OF THE INVENTION The present invention provides articles and methods of making such articles. In one aspect of the invention, a method of making an antimicrobial article is provided, the method comprising: applying a bismuth composition to a substrate ± to provide a liquid coating 125842.doc 200826950 cloth substrate 'silver composition" is included in a solvent a silver salt of non-sulph sulfate, a silver composition comprising a stabilizer in an amount of less than about 100 parts per million (100 ppm); a matrix; a material comprising a group selected from the group consisting of polyamines, polyesters , polyacetate, polyacrylic acid, polyolefin, polyurethane, polyvinyl chloride, polyvinyl alcohol, polycarbonate, polyvinylpyrrolidone, polylactic acid, ethylene vinyl acetate, polystyrene, Cellulose acetate, polyacrylate, polypropylene - decylamine, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, (polyvinyl ether, styrene_ethylene butylene-styrene elastomer, benzene Ethylene-butylene-styrene elastomer, styrene-isoprene-styrene elastomer, glass fiber, ceramic, and a combination of two or more of the foregoing; and a dry liquid coating substrate to provide inclusion Silver coated on a substrate The color of the microorganism is stable. In another sad case, the present invention provides an article comprising a silver salt of non-sulph sulfate, the silver salt is coated on the substrate; and a substrate comprising the selected from the following Materials of various composition groups: polyamide, polyester, polyacetate, polyacrylic acid, polyolefin, polyurethane, polyvinyl chloride, polyvinyl alcohol, polycarbonate, polyvinylpyrrolidone , polylactic acid, ethylene vinyl acetate, polystyrene, cellulose acetate, polyacrylate, polypropylene decylamine, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl ether, styrene - ethylene butylene-styrene elastomer, styrene-butene-stupyl elastomer, styrene-isoprene-styrene elastomer, glass fiber, ceramic, and two or more of the foregoing Combining; and wherein the article is microbiological and color stable. In another aspect of the invention, a method is provided comprising: applying a composition of 哿125842.doc 200826950 to a substrate to provide a liquid coated substrate , the silver composition package a silver salt containing a group selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver sulfate, silver citrate, silver iodate, silver lactic acid, silver silicate, silver nitrite, silver oxalate, phosphoric acid Silver, silver sulfadiazine, silver saccharinate, silver o-aminobenzoic acid, silver chlorite, fluorine; silver silver citrate, silver trihydrogen citrate, silver sulfite, silver acetyl phthalate, silver myristate, Silver palmitate, silver propionate, silver stearate, silver tartrate, weak protein silver, silver protein, and combinations of two or more of the foregoing; and heating liquid coating at a temperature sufficient to form silver metal from the silver salt The cloth substrate provides a color-stable antimicrobial article comprising silver metal nanoparticles and a silver salt. In another sad form, the present invention provides a method of making an antimicrobial article comprising: applying a silver composition to a substrate Providing a liquid coating substrate comprising a silver salt of non-sulph sulfate; and heating the liquid coating substrate at a temperature sufficient to form silver metal from the silver salt to provide a color comprising silver metal nanoparticles and a silver salt Stable antimicrobial Pieces. In another aspect, the present invention provides an article comprising: a silver metal and a silver salt disposed on a substrate, the silver salt being selected from the group consisting of silver acetate, silver benzoate, and silver carbonate. , gasified silver, silver citrate, silver iodate, silver lactic acid, silver nitrate, silver nitrite, silver oxalate, silver silver, silver sulfadiazine, silver strontium silver, silver phthalate, silver sulphate, Silver fluoroantimonate, silver triperhydride, silver nitrite, silver acetyl laurate, silver silver palmitate, silver propionate, silver stearate, silver tartrate, weak protein silver, silver protein and the like Two or more combinations. In still another aspect, the present invention provides an article comprising: a silver metal and a silver salt coated on a substrate of 125842.doc 200826950, the silver salt comprising a silver salt of non-sulph sulfate. It is to be understood that the terms used herein have the same meaning as understood by those skilled in the art. Despite the foregoing, it should be understood that certain groups have the meanings set forth herein. As used herein, "ambient temperature," means the current room temperature, typically in the range of from about 15 Torr to about 30 °C.

ί Relative humidity means the ratio of the amount of water actually present in the air to the maximum amount of water that can be reached at the same temperature. At least one and ''one or more I' can be used as used herein, ", " This is for use. When considering the implementation, various examples, and the scope of the accompanying patent application

The scope of the present invention will be more fully understood by those skilled in the art after the remainder of the invention. X [Embodiment] One invention provides an antimicrobial article containing silver. The articles are color stable (when exposed to UV or visible light), release antimicrobial silver ions, are surprisingly easy to manufacture and can be made into wound dressings, wounds containing violet materials or other suitable for direct application to wounds. Material. In describing embodiments of the present invention, it is meant that the color of the object is stable in color and/or color uniformity over time (for example, at least 4 T-seven hours after exposure to light). No significant changes are shown. Color variations can be evaluated in any of a variety of ways, and the invention is not limited by a particular method or technique to determine color changes. In certain embodiments of the invention J The color change is evaluated by observation. 125842.doc 200826950 - In some embodiments 'using a scale to evaluate color change. For example. § : By observing the sample under fluorescent illumination and by coloring it with color Standard • & Specify the color of the sample to a color rating of 0 to 10. Evaluate the level 0廿, 1 or 2 as “white,” which includes white to creamy yellow. Level 3 A K color 丨 includes light yellow to golden yellow and grades 6 to 10 are classified as rust to dark brown. The value of the 帛 color change is obtained by subtracting the initial level from the post-treatment level. A positive level of color change indicates a darker appearance and a negative C# level indicates a brighter appearance. A color change of 1 or less on this ruler is considered acceptable (e.g., no significant change) as long as the color is initially uniform and remains so. If the color is initially non-uniform, the color change of 〇5 is considered significant. In some embodiments, a colorimeter can also be used to measure color changes, such as the Minolta Chroma Meter (CR-3〇〇, using a three-color excitation value).

Komca Minolta Photo Imaging U.s.a·, Inc., Mahwah, made by law). A color change of 15% or less in the "Y" value on this ruler is considered to be acceptable as long as the sample color remains uniform. If the color is non-uniform, a 5% color change in the ΠΥ" value is considered significant. In other embodiments, the color change can be measured using a colorimeter according to test method ASTm D2244. The resulting CIELAB color difference (DE*) between the sample after exposure for a specified period of time and the unexposed sample can be determined. For reference purposes only, about 2 units of DE* or color change is considered to be a threshold detected by the naked eye and DE* of 20 or more represents a substantial or significant color change. It relies on the use of a compound called a stabilizer to provide color stability to articles comprising 125842.doc •10-200826950 silver salt. However, such stabilizers may also reduce the degree of dissolution of the silver salt such that the release of silver ions may be too low (less than 0.01 mg/g in water within 3 minutes) to be effective against wounds. In one embodiment of the invention, color stability is achieved by applying a silver composition to a substrate and drying the article. When a suitable substrate is used to make the article of the present invention, the dried article is color stable without the need to include a stabilizer or the like. In another embodiment of the present invention, color stability is achieved by the following operations: a portion of the silver salt (preferably less than 30%) coated on the substrate is reduced to nano-sized silver metal particles by drying at a high temperature. ("Nanoparticles,") to produce a color-stable product which has a color which is often observed as pale yellow to golden brown due to the formation of silver metal nanoparticles. In one aspect of the invention, a method of making an antimicrobial article is provided by coating (e.g., coating) a silver compound onto a substrate to provide a color stable antimicrobial article comprising a silver salt. In another aspect of the invention, a method of making an antimicrobial article is provided by coating (e.g., coating) a silver compound onto a substrate to provide a color stable antimicrobial article comprising silver metal and a silver salt. . In certain embodiments, the silver composition is first prepared by dissolving the silver salt in a suitable solvent, such as water, to provide a coatable liquid silver composition in the form of a silver salt solution. In certain embodiments, the solvent used in the silver composition consists of water. In certain embodiments, the solvent in the silver composition is primarily water and other ingredients that enhance the solubility of the silver salt. Silver salts suitable for use in the present invention may be selected from the group consisting of silver acetate, silver benzoate, carbonic acid 125842.doc 11 200826950 silver, silver chloride, silver citrate, reduction & iodonium silver, lactic acid Silver, silver nitrate, silver oxalate, silver silver, silver, nitrous oxide, silver acridine, silver sulphate, silver formic acid, silver sulphate, fluorine deficiency, sulphate, silver sulphate, secondary iodine Acid trihydrogen α silver, silver acetyl laurate, nutmeg ^ i , long-long silver nitrate, silver tartrate, weak egg & • silver, hard fat, silver, protein silver and a combination of two or more of the foregoing. Two or in some embodiments, the aforementioned hoof k-f is suitable for individual

Other silver salt combinations. The aforementioned riding stone, red... Early and exclusive with any Yimeng does not include silver sulfate. In certain embodiments, the silver 鴎 、, ά ά κ 糸 is selected from the group consisting of the following salts: silver acetate, broccoli, gamma, b ^ 酉 酉 、 silver, stone acid silver, chlorine Silver, citric acid, strontium, silver lactic acid, "silveric acid silver, sub-silver, silver chlorite, silver b-acid, silver trihydrogen silver, silver acetylate, silver propionate, silver tartrate , weak protein silver, protein silver, and a combination of two or more of the foregoing. In a second embodiment, the silver salt is selected from the following components: the silver is added to the silver, the silver oxalate, the silver acid, the silver, the silver saccharin, the silver phthalate, the second Silver nitrate, silver myristate, silver sulphate, silver stearate, and a combination of two or more of the foregoing. In certain embodiments, the silver salt is selected to exclude silver sulfate. In some embodiments, the silver salt is silver nitrate. In certain embodiments, the salt is a silver benzoate 0 silver composition that can be formulated to have a total of up to about 1.0% by weight in the composition, typically between about 0.01% by weight and about 5% by weight. Silver content. In some embodiments, the pH of the silver composition is maintained at a desired target value to avoid adverse effects on the substrate when the composition is applied to the substrate. In certain embodiments of 125842.doc -12-200826950, the pH of the silver composition is maintained at 9 or less. In certain embodiments, for example, the pH of the silver composition is maintained above 4 but less than 7 to minimize adverse effects on the cellulosic substrate. Color stability is achieved in the finished article of the invention without the need to include additional stabilizers in the silver composition; however, it will be appreciated that in certain embodiments of the invention, a small amount of stabilizer may be included in the silver composition. . Stabilizers include ammonia, ammonium salts (eg, ammonium acetate, ammonium sulfate, ammonium carbonate, and the like), thiosulfate, water-insoluble metal salts (eg, such as vaporized compounds), peroxides, Magnesium trisilicate and/or polymer. When the stabilizer is present in the silver composition, it may be present in an amount less than 10 Å pprn. In certain embodiments, the stabilizer may be present in an amount less than 50 Ppm, and in some embodiments in an amount less than 20 ppm, based on the total weight of the silver salt composition. Alternatively, the stabilizing agent is present in an amount less than 1 〇〇〇 ppm based on the total weight of the dry color stable antimicrobial article. In other embodiments, the stabilizer is present in an amount less than 500 ppm based on the total weight of the dry color stable antimicrobial article, and in other embodiments, is stable based on the total weight of the dry color stable antimicrobial article. The agent is present in an amount less than 100 ppm. In certain embodiments, the silver composition can optionally include a compound that promotes solubility of the silver salt in a solvent (e.g., water). Depending on the solubility of the salt selected for use in the present invention, embodiments of the present invention may include a solvent selected from the group consisting of co-solvents, ammonium carbamate, acetic acid, carbonic acid, and peroxygen shed. Ammonium ammonium tetraborate, triammonium citrate, ammonium urinate, ammonium hydrogencarbonate, apple I ammonium, ammonium nitrate, ammonium nitrite, ammonium succinate, ammonium sulfate, tartar 125842.doc -13- 200826950 acid According to two or more combinations of two substances. In selecting a co-solvent to be included in the silver composition of the present invention, it is preferred to evaporate or degrade the composition as described herein after it has been applied to the substrate and heated. The silver composition thus formulated is applied to a substrate to provide a liquid coating matrix. In certain embodiments, the silver composition will penetrate and impregnate into the interior of the matrix. For example, when an absorbent material such as gauze is used, the silver composition is impregnated between the fibers of the substrate. The coating of the silver composition onto the substrate can be accomplished in a sequential process, or can be carried out in discrete ways and even in a single step. Any of a variety of materials can be used as the matrix or matrix material for coating the silver composition. In certain embodiments, suitable materials may include or consist of a long chain macromolecule. In certain embodiments, the matrix material is typically selected to be non-oxidizable because it is in a silver salt (eg, silver nitrate). In the presence of heat, it is not susceptible to oxidation when heated to a temperature below about 120 C. Suitable substrates include materials selected from the group consisting of or consisting of: polyamines, polyesters, polyacetates, poly Acrylic acid, polyolefin (for example, polypropylene polyethylene, ethylene-ene propylene copolymer and ethylene butene copolymer), polyurethane (including polyurethane foam), polyvinyl chloride, poly Vinyl alcohol, polycarbonate, polyvinylpyrrolidone, polylactic acid, ethylene vinyl acetate, polystyrene, ethyl cellulose, polyacrylate, polypropylene decylamine, polyacrylonitrile, polyvinylidene fluoride, Polytetrafluoro Ethylene, polymethyl, polyvinyl ether, styrene ethylene butylene-styrene elastomer, styrene_butene_styrene elastomer, styrene-isoprene-styrene elastomer, glass fiber, pottery And combinations of two or more of the foregoing materials 125842.doc -14-200826950. In some embodiments of the invention 'the matrix comprises or consists of cellulose acetate. In some embodiments, the matrix Containing or consisting of polyamines (eg nylon 6,6). In certain embodiments, suitable materials may include cellulosic materials and non-fibrous materials such as paper, natural or synthetic fibers, threads and yarns, It is made of materials such as cotton, 嫘f, hemp, jute, bamboo fiber, cellulose acetate, 竣methylation> gluten-spun cellulosic fiber, polyamine, yttrium acetate/alginate, Collagen, gelatin, natural rubber, & acrylamide: a combination of two or more of the foregoing. In addition, the above materials or combinations thereof may be combined with other materials such as polyester, polyacrylic acid, poly Olefins (for example Polypropylene polyethylene, ethylene propylene copolymer and ethylene butene copolymer), polyurethane (including polyurethane foam), vinyl including polyethylene, polystyrene, glass Fiber, ceramic fiber, polyacrylate, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl alcohol, polylactic acid, polyvinyl ether, polyvinylpyrrolidone, polycarbonate, benzene Ethylene-ethylene butylene-ethylene elastomer, styrene-butene-styrene elastomer, styrene-isoprene-styrene elastomer, and combinations of two or more of the foregoing. A combination of materials may be included. In certain embodiments, the matrix

A material selected from the group consisting of cellulose materials, nylon, polyester fibers, and a combination of two or more of the foregoing. A, for example, the substrate may be porous or non-porous, and the silver composition may be applied to the surface of the substrate or sub-crushed thereto. In an embodiment of the invention, the substrate may be 125842.doc 200826950: compliant and may comprise woven or non-woven materials made from natural or synthetic compounds. In an embodiment of the invention, the & mass may be selected from the group consisting of polymeric webs (10) woven or woven), polymeric films, hydrocolloids, foams, paper, and/or combinations of the foregoing. In some embodiments, the substrate can be a cotton gauze.

Porous substrates made of the foregoing materials may include woven fabrics, woven fabrics (e.g., thick cotton and gauze), non-woven fabrics (including spunbonded non-woven fabrics), and BMF (blown microfibers), extruded porous sheets, and perforations. Sheet. The pores (i.e., openings) in the porous matrix are of sufficient size and sufficient number to facilitate high gas permeability. For certain embodiments, the porous substrate has at least one pore/square A knife. For certain embodiments, the porous substrate has no more than 225 pores per square centimeter. For certain embodiments, the apertures have an average opening size (i.e., a maximum opening size) of at least 1 millimeter (mm). For certain embodiments, the pores have an average opening size (i.e., a maximum opening size) of no greater than 0.5 centimeters (cm). In certain embodiments, the porous substrate has a basis weight of at least 5 grams per square meter. In certain embodiments, the porous substrate has a basis weight of no greater than 1 gram per square meter, and in certain embodiments no greater than 200 grams per square meter. The porous substrate can be flexible but still resistant to cracking. For certain embodiments, the porous substrate has a thickness of at least about 0.0125 millimeters (mm). For certain embodiments, the porous substrate has a thickness of no greater than about 15 mm and, for some embodiments, no greater than about 3 mm. In some embodiments, the matrix comprises a permeable material that allows moisture vapor to pass therethrough. For certain embodiments, the matrix may be a hydrocolloid, such as a hydrophilic polymer, as described in U.S. Patent Application Publication No. 125, 842, doc- s, s, s. Or a hydrophobic polymer matrix containing hydrophilic particles. Cellulosic materials are suitable for use in certain embodiments of the invention, including polysaccharides or modified polysaccharides, regenerated cellulose (such as mash), paper, cotton, carboxymethyl cellulose, and the like. In embodiments of the invention where the finished article is intended for use as a wound dressing or will be used in a wet or wet environment, it may be advantageous to provide a matrix comprising an absorbent material. Suitable absorbent materials include absorbent materials made of or incorporated into cellulosic fibers such as carboxymethylated materials - carboxymethylated cotton, carboxymethylated cellulose, carboxylic acid Methylated hydrazine. Suitable commercial cellulosic fibers include solvent-spun cellulosic fibers available from Lenzing Fibers, Inc. under the trademark "TENCEL". As disclosed in WO 1993012275 A1, the above-described TENCEL fiber 竣 methylation variant is also suitable. In certain embodiments of the invention, in some embodiments, the matrix is substantially liquid impermeable, particularly impervious to wound secretions. The silver combination can be applied at ambient temperature, typically at temperatures less than about 7 (rc). The silver composition can be applied to a substrate using any of a variety of known coating techniques, such as gravure coating, curtain coating, extrusion coating. , knife coating, roll coating, spraying, and the like. In some embodiments, the substrate can be immersed or passed through a bath of silver composition. After coating the silver salt, the liquid can be at a temperature The coated substrate is subjected to moderate heating for a time sufficient to dry the article to provide a color stable anti-micro 125842.doc -17-200826950 biological article. A sufficient high temperature can be obtained in an oven, and in certain embodiments of the invention the temperature is less than 100. Typically, it is usually in the range of from about 5 (rc to about 9 (rc). Alternatively, the liquid-coated substrate can be air dried at ambient or room temperature. The actual drying temperature can be visually divided into the amount of time to dry, the liquid coated substrate. The silver loading, the type and weight of the substrate, and the like are varied. Those skilled in the art will appreciate that the temperature should be high enough to dry the article without reducing the silver or oxidized group f. The article is color stable. It is not intended to be theoretically constrained, and the article of the invention produced in this manner is color stable due to the use of a non-oxidizable matrix. For some embodiments of the invention, as long as the substrate is not made of silver nitrate The oxidation can form a silver metal or the matrix does not melt or burn, and the drying temperature can be higher than 1 〇. Polyester is an example of such a base. In some embodiments, the liquid is coated at a temperature. The substrate is heated for a time sufficient to dry the article (by removing the solvent from the silver composition) and reduce at least a portion of the silver salt to silver metal to provide a color stable antimicrobial article. Part of the silver metal is in the form of silver nanoparticles. As used herein, ''nanoparticles' refers to microscopic particles having dimensions of at least one dimension less than about 200 nm measured in nanometers. To achieve silver metal Forming, increasing the drying temperature of the liquid coating substrate to above room temperature. Obtaining sufficient temperature in the oven 'and in certain embodiments of the invention, the temperature exceeds about 95. 在 and at about 95 C to about 225 Within the scope of C. In some embodiments, the liquid coating substrate is dried at a temperature between about 1 ° C and about 200 ° C. In other embodiments, at about 11 (TC versus about 18 〇〇) The liquid coated substrate is dried at a temperature between c. In other embodiments, the liquid coated substrate is dried at a temperature between about 13 〇〇c and about 175 t: 125842.doc -18. The actual drying temperature may vary depending on the time during which the drying is applied, the silver loading on the liquid coated substrate, the type and weight of the substrate, and the like. Those skilled in the art will appreciate that in embodiments where desired, the temperature should be sufficiently high to achieve reduction of silver (1). However, the melting temperature and oxidation potential of the substrate must also be considered. Those skilled in the art will appreciate that matrix materials suitable for use as wound dressings, for example, may comprise materials that are susceptible to oxidation at elevated temperatures (eg, cellulosic materials) such that prolonged heating or exposure to extreme temperatures may result in finished articles. Harmful in quality and / or integrity. The drying temperature of the crucible may burn or melt certain matrix materials and render them unsuitable for their intended purpose (e.g., as a wound dressing). In certain embodiments, the finished article comprises silver metal and a silver salt attached to the substrate. Without wishing to be bound by any theory, it is believed that in certain embodiments, a two-part hot-coating substrate will oxidize the substrate and reduce the silver salt to silver metal. The oxidation of the matrix and the formation of metallic silver nanoparticles result in color and color stability observed in some of the finished antimicrobial articles of the present invention. When a white matrix (e.g., cellulosic material) is used, the heat-treated liquid-coated substrate can produce a finished article having a non-white color (e.g., yellow to brown) that is stable for extended periods of time after exposure to light and/or heat. The article of the present invention preferably remains stable to light (e.g., visible light, uv) such that it is color stable. Preferably, it releases an antimicrobially effective amount of silver ions and in some embodiments of the invention it is readily suitable for use as a wound dressing for skin wounds. These items are easy to manufacture and generally contain no additional stabilizers. In certain embodiments of the present invention, the present invention provides a wound dressing comprising a silver salt which is readily applied to a substrate and which is soluble in 125842.doc -19.200826950. In other embodiments, the present invention provides wound dressings comprising silver metal nanoparticles coated on and placed on a substrate, as well as readily soluble silver salts. As used herein, "coated on, and, placed on" means placing silver on a substrate such that silver and/or silver salts are on the surface of the substrate, and in the case of absorbent materials, silver and / or silver salts may also be distributed inside the matrix (eg, an absorbent structure extending between the outermost surfaces). In embodiments in which the finished article is used as a wound dressing, the antimicrobially effective amount of silver can be effectively delivered from the article to the wound bed or the like. The item typically maintains an effective level of silver release (e.g., a dressing greater than 0.01 mg/g in 1 〇〇 g of water within 3 ) minutes). The color of the finished object (for example, heat and light) is stable. After exposing the article to visible or UV light, in some embodiments of the invention, the article color is stable for more than 4 hours, in some embodiments, for more than 8 hours, and in some implementations In the case of more than 24 hours. The light stability of the article of the invention can be extended by encapsulating the article in an opaque package or storing the article in a matte environment until the article is used. The concentration of silver on a dry substrate (in some embodiments a silver salt and in some embodiments a silver salt plus a silver metal) is preferably less than about 4 Å, 〇〇〇 mg (mg) Ag / kg. (kg) matrix, and in certain embodiments less than about 2 〇, 〇〇〇mg Ag/kg matrix. In other embodiments, the silver concentration is less than about 1 Torr, 〇(10) mg Ag/kg matrix. In an embodiment of the invention wherein silver is present in the form of a silver salt and a silver metal, less than 30% of the total amount of silver on the substrate is typically in the form of a silver metal. In some embodiments, the article of the present invention is a medical article such as a wound 125842.doc -20-200826950 dressing and wound dressing material or other material that is directly applied to or in contact with the wound. However, the articles of the present invention can be used in other applications (medical and non-medical applications) that require or require the antimicrobial properties of silver. Other potential products include clothing, bedding, shelters, wipes, insoles, diapers, and hospital materials such as blankets, surgical covers, and gowns. The stability of the article of the present invention may be extended and/or increased when the relative humidity is maintained at 50% or less at room temperature; more preferably at 3% or less; and most preferably at 20% or less. The relative humidity of the article of the present invention can be reduced to 30%, and preferably to 20% or less by a number of methods, such as, for example, 1) placing the article at 3% or less, Good 2〇. /. Or encapsulating the article in a relatively low humidity environment, and then in the same environment; 2) drying the liquid coating substrate in a drying oven and immediately encapsulating the resulting article; and/or 3) adding a desiccant to the article package. Environments suitable for maintaining low humidity include packages made of materials with low moisture vapor transmission (MVTR), such as Techni_p〇uch packaging with PET/aluminum box/LLDPE material construction (eg, available from Technipaq, Inc.) ·, Crystal Lake, IL). In certain embodiments, the articles of the present invention are non-adhesive, but it will be appreciated that an adhesive (e.g., a pressure sensitive adhesive) can be applied to the article in a known manner. A pressure sensitive adhesive suitable for use in a medical article can be used in the article of the present invention. That is, a pressure-sensitive adhesive may be applied to the surface of the article of the present invention to be coated around the periphery to adhere the silver-containing surface of the article to the skin to be in contact with the wound or the like. In this way, under wet conditions in the wound bed, the article will release silver ions into the wound to prevent microbial growth. 125842.doc -21 - 200826950 In certain embodiments. One or both sides of the substrate coated with the silver composition may be covered by a permeable non-adhesive outer layer to reduce adhesion to the wound and adherence. For example, the non-adhesive layer can be attached to the substrate by coating or lamination. Or 'can seal the coating substrate in a non-adhesive layer (such as a sleeve). The non-adhesive layer can be coated with a non-adhesive woven or non-woven fabric such as nylon or cotton, y, or a perfluorinated material on the cloth. Made of layers). The non-adhesive layer prevents the wound from sticking to the wound. At the same time, the non-adhesive layer does not adversely affect the sustained release of silver from the coated substrate. (In another embodiment, the substrate or support matrix may comprise a non-adhesive material. For example, 'US Patent Publication Nos. 2〇〇4/〇18〇〇93, 2005/0123590, and 2005/ A non-adhesive, hydrophilic polymer can be used as a matrix or support material, or applied to a permeable porous substrate, as described in 0124724. If desired, two protective films (eg, polyester film) can be used. Covering the coated substrate. These films may optionally include non-stick treatments and may be used to facilitate self-assembly of the package and help in handling the article. If desired, the coated substrate may be classified as applicable. Individual compresses of the size, encapsulated in a sealed sachet and sterilized. & Illustrative Example 1 A method of making an antimicrobial article comprising: applying a silver composition to a substrate to provide a liquid coating Base #, the silver plant comprises a silver salt of non-sulphate in a solvent, the silver composition comprising a stabilizer in an amount of less than about 100 ppm; the matrix comprising a material selected from the group consisting of: polylactam, 125842.doc •22· 200826950 Polyester, polyacetate, polyacrylic acid, polyolefin, polyurethane, polyvinyl chloride, polyvinyl alcohol, polycarbonate, polyethylene, ketone, polylactic acid, ethylene acetic acid Vinyl ester, polystyrene, cellulose acetate, polyacrylate, polypropylene decylamine, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl ether, styrene-ethylene butene-benzene Ethylene elastomer, styrene-butene styrene elastomer, styrene-isoprene-styrene elastomer, glass fiber, ceramic, and a combination of two or more of the foregoing; and drying the liquid coating A cloth substrate to provide a color-stable antimicrobial article comprising a silver salt coated on a substrate. 2. The method of embodiment 1, wherein the silver salt is selected from the group consisting of silver acetate, silver stearate , silver carbonate, silver chloride, silver citrate, silver lactic acid, silver nitrate, silver nitrite, silver sulfite, silver fluoroantimonate, silver trihydrogen hydride, silver acetate, silver propionate, tartaric acid Two or two of silver, weak protein silver, silver protein, and descriptive substances 3. The method of embodiment 2, wherein the silver salt is silver nitrate. 4. The method of embodiment 2, wherein the silver salt is silver benzoate. 5. The method of embodiment 1, wherein The silver salt is selected from the group consisting of silver citrate, silver oxalate, silver citrate, continuous amine feed biting silver, silver saccharinate, silver ortho-aminobenzoate, silver nitrite, silver myristate, silver palmitate. And a combination of two or more of the foregoing, the method of any one of embodiments 1 to 5, wherein the substrate comprises a polyolefin selected from the group consisting of: poly A combination of propylene, polyethylene, ethylene propylene copolymer, ethylene butene copolymer, and two or more of the foregoing, 125842.doc -23-200826950 Γ 。. 7. A compound according to any one of embodiments 1 to 5, which is deamined. 8. De-cellulose according to any one of embodiments 1 to 5. 9. A material according to any one of Embodiments 1 to 8 which is composed of the following: abbreviated from ^ A 1 η leaf, as a knot, a braid, a non-woven fabric, an extruded porous sheet And perforated sheets. 10. The method according to any one of embodiments 1 to 9, wherein the silver composition comprises less than "^ ^ ^ Τ" at a total weight of the silver salt composition at a stability of 50 ppmi篁Agent. η. The method of embodiment 10, wherein the silver composition does not comprise a stabilizer. The method of any of embodiments 1 to 11, wherein drying the liquid coating substrate is effected at room temperature. The method of any one of embodiments 1 to 11, wherein the liquid-coated substrate is dried at a temperature of less than about 1 Torr (rc). 14 as in any of embodiments 1 to 13. The method of claim 7, wherein the color-stabilized antimicrobial article comprises a silver salt coated on a substrate having a silver 7 degree of less than about 40,000 mg Ag/kg matrix on the substrate. 15. The method of embodiment 14, wherein The color stable antimicrobial article comprises a silver salt coated on a substrate having a silver concentration of less than about 20.000 mg Ag/kg matrix. 16_A method as in Example 15, wherein the color stabilized antimicrobial article a silver salt coated on a substrate having a silver concentration of less than about 10.000 mg Ag/kg matrix. wherein the matrix comprises polyfluorene wherein the matrix comprises acetic acid, wherein the matrix comprises a substrate selected from the group consisting of 125842.doc -24-200826950 1 7 _ - an article comprising: a non-sulphate silver salt applied to a substrate; and a substrate comprising a material selected from the group consisting of polyamine, polyester, Polyacetate, polyacrylic acid, polyolefin, Urethane, polyethylene, polyvinyl alcohol, polycarbonate, polyvinylpyrrolidone, polylactic acid, ethylene vinyl acetate, polystyrene, cellulose acetate, polyacrylate, polyacrylamide, poly Acrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl ether, styrene-ethylene butylene-styrene elastomer, stupid ethylene _ butylene styrene elastomer, styrene-isoprene a diene-styrene elastomer, a glass fiber, a ceramic, and a combination of two or more of the foregoing, wherein the article is antimicrobial and color stable. 18. The article of embodiment 17, wherein the silver salt is Select from the following groups of components: silver acetate, silver benzoate, silver carbonate, silver vapor, silver citrate, silver iodate, silver lactate, silver nitrate, silver nitrite, silver oxalate, silver phosphate, silver sulfadiazine, Saccharin silver, silver ortho-aminobenzoate, silver sulfite, silver fluoroantimonate, silver triperhydride, silver hypophosphite, silver acetyl laurate, silver myristate, silver palmitate, silver stearate , silver propionate, silver tartrate, weak protein silver, egg And a combination of two or more of the foregoing, wherein the silver salt is selected from the group consisting of silver acetate, silver carbonate, silver chloride, and the like. , silver citrate, silver lactic acid, silver nitrate, silver nitrite, silver sulfite, silver fluoroantimonate, silver trihydrogen hydride, silver acetate, silver propionate, silver tartrate, weak protein silver, protein Silver and a combination of two or more of the foregoing. 125842.doc -25- 200826950 2 0. The article of Embodiment 1 wherein the silver salt is silver nitrate. 21. The article of embodiment 19, wherein The silver salt is silver benzoate. 22. The article of embodiment 18, wherein the silver salt is selected from the group consisting of silver iodate, silver oxalate, silver silver, silver sulfadiazine, and sugar. And silver ortho-aminobenzoate, silver hypophosphite, silver myristate, silver palmitate, silver stearate, and a combination of two or more of the foregoing. The article of any one of embodiments 17 to 22, wherein the matrix comprises polyamine. The article of any one of embodiments 17 to 22, wherein the substrate comprises cellulose acetate. The object of any one of embodiments 17 to 24, wherein The silver concentration is less than about 40,000 mg Ag/kg matrix.. 26. The article of embodiment 25, wherein the silver concentration on the substrate is less than about 20,000 mg Ag/kg matrix. 27. The article of embodiment 26, wherein on the substrate The silver concentration is less than about 10,000 mg Ag/kg of the substrate. The article of any one of embodiments 17 to 27, wherein the concentration of the stabilizer is less than about 1000 ppm based on the total weight of the article. The article of claim 28, wherein the concentration of the stabilizer is less than about 500 ppm based on the total weight of the article. 30. The article of embodiment 29 wherein the concentration of the stabilizer is less than about 100 ppm based on the total weight of the article. A method of making an antimicrobial article comprising: applying a silver composition to a substrate to provide a liquid coating substrate, the silver group 125842.doc -26-200826950 comprising a group selected from the group consisting of Silver salt: silver acetate, silver benzoate, silver carbonate, Silver, silver citrate, silver citrate, silver lactic acid, silver nitrate, silver sulfite, silver oxalate, silver phosphate, continued (four) money, silver saccharinate, silver ortho-benzoic acid, silver chlorite, silver fluoroantimonate , urinary silver trihydrogen silver, silver nitrite, silver propionate silver myristate, silver palmitate, silver propionate, silver stearate, silver tartrate, weak protein silver, silver protein and two of the above or a combination of two or more; and

The liquid coating substrate is heated at a temperature sufficient to form silver metal from the silver salt to provide a color stable antimicrobial article comprising silver metal nanoparticles and a silver salt. 32. The method of embodiment 31, wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver sulfate, silver citrate, silver lactate, silver nitrate, silver nitrite And a combination of two or more of silver sulfite, silver fluoroantimonate, silver dihydrogenate, silver acetylate, silver propionate, silver tartrate, weak protein silver, protein silver, and the foregoing. 33. The method of embodiment 32 wherein the silver salt is silver nitrate. 34. The method of embodiment 32, wherein the silver salt is silver benzoate. 35. The method of embodiment 31, wherein the silver salt is selected from the group consisting of silver iodate, silver oxalate, silver phosphate, silver sulfadiazine, silver saccharinate, silver ortho-aminobenzoate, silver silver nitrite, Silver myristate, silver palmitate, silver stearate, and combinations of two or more of the foregoing. The method of any one of embodiments 31 to 35, wherein the matrix comprises a material selected from the group consisting of cellulose materials, nylon, polyamine, polyacetate, collagen, gelatin, Polyacrylamide, natural 125842.doc -27- 200826950 Rubber, alginate and a combination of two or more of the foregoing. 37. The method of embodiment 36, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefins, polyurethanes, vinyls comprising polyethylene, Polystyrene, glass fiber, ceramic fiber, polyacrylate, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl alcohol, polylactic acid, polyvinyl ether, polyvinylpyrrolidone, poly Carbonate, styrene-ethylene butylene-styrene elastomer, styrene-butylene-styrene elastomer, styrene-isoprene-styrene elastomer, and combinations of two or more of the foregoing . 38. The method of embodiment 36 or 37, wherein the matrix comprises a fibrous material. 39. The method of embodiment 38, wherein the cellulosic material is an absorbent slow-methylating material selected from the group consisting of: methylated cotton, drum methylated cellulose, carboxymethylated Solvent spun cellulose fibers and carboxymethyl hydrazine and combinations of two or more of the foregoing. 40. The method of embodiment 38, wherein the cellulosic material is selected from the group consisting of cotton, alfalfa, hemp, jute, bamboo fiber, cellulose acetate, carboxymethylated solvent-spun cellulose fibers And a combination of two or more of the foregoing. The method of any one of embodiments 31 to 40, wherein the substrate comprises a material selected from the group consisting of: a braid, a braid, a non-woven fabric, an extruded porous sheet, and a perforated sheet. The method of any one of embodiments 31 to 41, wherein heating the liquid coating substrate is effected at a temperature in the range of from about 225 C. 125842.doc -28- 200826950 43. The method of embodiment 42, wherein at about 100. Heating the liquid coating substrate is achieved at a temperature in the range of about 2 °C. 44. The method of embodiment 43, wherein the heating the liquid coating substrate is effected at a temperature in the range of from about uo ° c to about i 8 (rc). 45. The method of embodiment 44, wherein at about i3 〇 °c to The liquid coating substrate is heated at a temperature in the range of about 175. The method of any one of embodiments 31 to 45, wherein the silver salt solution comprises less than 1 总 based on the total weight of the silver composition. The method of embodiment 46, wherein the silver salt solution does not comprise a stabilizer. The method of any one of embodiments 31 to 47, wherein the antimicrobial article is a color Stable and non-white color. 4 9 · A method of making an antimicrobial article, comprising: applying a silver composition to a substrate to provide a liquid coating substrate comprising a silver salt of non-sulphate sulfate And heating the liquid coating substrate at a temperature sufficient to form silver metal from the silver salt to provide a color stable antimicrobial article comprising silver metal nanoparticles and a silver salt. 50. The method of embodiment 49, wherein the silver The salt is selected from the following Group: silver acetate, silver benzoate, silver carbonate, silver chloride, silver citrate, silver lactate, silver nitrate, silver nitrite, silver sulphate, silver fluoroantimonate, silver dihydrogen hydride, acetonitrile Silver acid, silver propionate, silver tartrate, weak protein silver, silver protein, and a combination of two or more of the foregoing. 51. The method of embodiment 50, wherein the silver salt is silver nitrate. The method of claim 50, wherein the silver salt is silver benzoate. 125842.doc • 29-200826950 3. The method of embodiment 49, wherein the silver salt is selected from the group consisting of silver oxalate, silver silicate, A combination of two or more of the genistein cancer, silver, saccharin, silver, silver oxalate, silver gluconate, silver sulphate, silver stearate, and the foregoing. The method of any one of Examples 49 to 53, wherein the substrate comprises a material selected from the group consisting of: cellulose material, nylon, polyamine, polyacetate, and glandular protein , gelatin, polypropylene decylamine, natural rubber, alginate, and two or more of the foregoing 55. The method of embodiment 54, wherein the substrate further comprises a material selected from the group consisting of polyacrylic acid, polyacrylic acid, polyolefin, polyaminomethyl hydrazine, polyvinyl chloride, polyphenylene Ethylene, glass fiber, ceramic fiber, polyacrylic acid vinegar, polyacrylonitrile, polyvinylidene chloride, polytetrafluoroethylene, polyformic acid, polyethylene glycol, polylactic acid, polyethylene scale, polyethylene decyl ketone, Polysulfate, styrene-ethylene butylene-styrene elastomer, styrene-butene-styrene elastomer, styrene, isoprene-styrene elastomer, and two or two of the foregoing The combination of the above. The method of embodiment 54 or 55, wherein the matrix comprises a cellulosic material. 57. The method of embodiment 56, wherein the cellulosic material comprises an absorbent carboxymethylated material selected from the group consisting of: carboxymethylated cotton, carboxymethylated cellulose m-solvent fibers A combination of two or more of a fibril and a hydrazine methylated snail and a substance as described above. 58. The method of embodiment 56, wherein the cellulosic material is selected from the group consisting of cotton, alfalfa, hemp, jute, bamboo fiber, acetate fiber 125842.doc -30-200826950, Carboxymethylated solvent-spun fiber + total male a 4 l μ丄^ ι 爽 京 纤维 fiber and a combination of two or more of the foregoing. The method of any one of embodiments 49 to 58, wherein the substrate comprises a material selected from the group consisting of: a braid, a braid, a non-woven fabric, an extruded porous sheet, and a perforated sheet. The method of any one of embodiments 49 to 59, wherein the heating the liquid coating substrate is effected at a temperature ranging from about priced to about 225 °C. 61. For example, the method of yoke 60 is only about 1 〇〇. The liquid coating substrate is heated to a temperature within about 2 Torr. 62. The method of embodiment 61, wherein is about 11 Torr. 〇 to about 18 〇. Heating the liquid coating substrate is achieved at a temperature within the range of 〇. 63. The method of embodiment 62, wherein is about 13 Torr. 〇 to about 175. Heating the liquid coating substrate is achieved at a temperature within the range of 〇. The method of any one of embodiments 49 to 63, wherein the silver salt solution comprises a stabilizer in an amount less than 丨〇〇ρρπι based on the total weight of the silver composition. 65. The method of embodiment 64, wherein the silver salt solution does not comprise a stabilizer. The method of any one of embodiments 49 to 65, wherein the antimicrobial article is color stable and has a non-white color. 67. An article comprising: a silver metal and a silver salt disposed on a substrate, the silver salt being selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver chloride, silver citrate, Silver moth, silver lactic acid, silver nitrate, silver nitrite, silver oxalate, silver phosphate, silver chlorpyrifos, silver saccharinate, silver ortho-aminobenzoate, silver chlorite, silver fluorite, secondary molybdenum Trihydrogen silver, silver hypophosphite, silver acetate, meat 125842.doc -31- 200826950 silver myristate, silver palmitate, silver propionate, silver stearate, silver tartrate, weak protein silver, protein silver and the foregoing Two or more combinations of substances. 68. The article of embodiment 67, wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver chloride, silver citrate, silver lactate, silver nitrate, silver nitrite , silver chlorite, silver fluoroantimonate, silver trihydrogen hydride, silver acetate, silver propionate, silver tartarate, weak protein silver, silver protein and combinations of two or more of the foregoing . 69. The article of embodiment 68 wherein the silver salt is silver nitrate. 70. The article of embodiment 68 wherein the silver salt is silver benzoate. 71. The article of embodiment 67, wherein the silver salt is selected from the group consisting of silver sulphate, silver sulphate, silver sulphate, and amine. A combination of two or more of silver, silver saccharin, silver ortho-aminobenzoate, silver hypophosphite, silver myristate, silver palmitate, silver stearate, and the foregoing. The article of any one of embodiments 67 to 71, wherein the matrix comprises a material selected from the group consisting of: cellulose materials, nylon, polyamide, polyacetate, collagen, gelatin , polypropylene decylamine, natural rubber, brown acid salt and a combination of two or more of the foregoing. 73. The article of embodiment 72, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefin, polyurethane, polyethylene, polystyrene, glass. Fiber, ceramic fiber, polyacrylic acid vinegar, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polymethylamide, polyethylene glycol, polylactic acid, polyvinyl ether, polyethylene, slightly biting, polycarbonate Ester, styrene_ethylene butylene_styrene elastomer, styrene_butene_styrene elastomer, styrene-isoprene-styrene elastomer and the foregoing 125842.doc -32- 200826950 Kind or a combination of two or more. 74. The article of embodiment 72 or embodiment 73, wherein the substrate comprises a fibrous material. 75. The article of embodiment 74, wherein the cellulosic material comprises an absorbent carboxymethylated material selected from the group consisting of carboxymethylated cotton, carboxymethylated cellulose, and a methylated solvent. Spun cellulosic fiber and slow methylated hydrazine and a combination of two or more of the foregoing. The article of embodiment 74, wherein the cellulosic material is selected from the group consisting of cotton, alfalfa, hemp, jute, bamboo fiber, cellulose acetate, It methylated solvent-spun fiber A combination of two or more of a plain fiber and the foregoing. The article of any one of embodiments 67 to 76, wherein the substrate is a material selected from the group consisting of: a braid, a braid, an extruded porous sheet, and a perforated sheet. The article of any one of embodiments 67 to 77, wherein the antimicrobial article is color stable and has a non-white color. Wherein silver on the substrate 79. The concentration of the article of any of embodiments 67 to 78 is less than about 40,000 mg Ag/kg matrix. Wherein the concentration of silver on the substrate is less than about wherein the concentration of silver on the substrate is less than about 80. The article of Example 79 is a 20,000 mg Ag/kg matrix. 8 1 · Item as in Example 8 10,000 10,000 mg Ag/kg matrix. 82. An article comprising: the silver salt comprising silver non-sulphate coated on a substrate with silver metal and a silver salt 125842.doc -33 - 200826950 silver salt. 83. The article of embodiment 82 wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver vapor, silver citrate, silver lactate, silver sulphate, Silver nitrite, silver chlorite, silver fluorite, silver trihydrogen hydride, silver acetate, silver propionate, silver tartrate, weak protein silver, silver protein and two or two of the foregoing A combination of the above. 84. The article of embodiment 83 wherein the silver salt is silver nitrate. 85. The article of embodiment 83 wherein the silver salt is silver benzoate. 86. The article of embodiment 82, wherein the silver salt is selected from the group consisting of silver formate, silver oxalate, silver linoleate, and amine. Mercury silver, saccharin silver, silver ortho-aminobenzoate, silver hypophosphite, silver myristate, silver palmitate, silver stearate, and combinations of two or more of the foregoing. The article of any one of embodiments 82 to 86, wherein the matrix comprises a material selected from the group consisting of cellulosic materials, nylon, polyamine, polyacetate, collagen, gelatin, Polyacrylamide, natural rubber, alginate, and a combination of two or more of the above. 88. The article of embodiment 87, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefin, polyurethane, polyethylene, polystyrene, glass. Fiber, ceramic fiber, polyacrylate, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polymethylpolyvinyl alcohol, polylactic acid, polyethylene ether, polyethylene 吼 π pyridine ketone, poly snail曰 曰, styrene _ ethylene butylene styrene elastomer, styrene-butene styrene elastomer, styrene-isoprene styrene elastomer and combinations of two or more of the foregoing . The article of embodiment 87 or embodiment 88, wherein the matrix comprises a cellulosic material. 90. The article of embodiment 89, wherein the cellulosic material comprises an absorbent carboxymethylated material selected from the group consisting of carboxymethylated cotton, mercaptomethylated cellulose, carboxymethylated solvent Spun cellulosic fiber and carboxymethylated hydrazine and a combination of two or more of the foregoing. The article of embodiment 89, wherein the cellulosic material is selected from the group consisting of

A group consisting of: #, 嫘荣, 麻麻, 黄厨1, bamboo fiber, cellulose acetate, carboxymethylated solvent cellulose fiber, and a combination of two or more of the foregoing. 92. The article of any of embodiments 82 to 91, wherein the substrate is a material selected from the group consisting of: a braid, a braid, an extruded porous sheet, and a perforated sheet. Wherein the antimicrobial material is silver on the substrate. 93. The article of any one of embodiments 82 to 92, the article being color stable and having a non-white color. 94. The article of any one of embodiments 82 to 93, having a concentration of less than about 40,000 mg Ag/kg matrix. % of the article of Example 94 wherein the silver concentration on the substrate is less than about 20,000 mg Ag/kg matrix. Wherein the silver concentration on the substrate is less than about 96. The article of Example 95 is a 10,000 mg Ag/kg matrix. EXAMPLES The objects and advantages of the present invention are illustrated by the following examples in the examples, but the specific materials and amounts thereof, as well as other conditions, and the = 125842.doc -35-200826950 sections are deemed to be inappropriate. Limit the invention. Unless otherwise stated, all parts and percentages are by weight, all water is distilled water and all molecular weights are weight average molecular weights.

I Example 1-1 by placing 0.36 grams (g) of silver tartaric acid (Aldrich Chemical Co., > Milwaukee, WI) and 200 g of distilled water in a glass vial and capping at room temperature A silver nitrate coating solution was prepared by mixing overnight in an shaker. ί : Approximately 6 grams of this silver nitrate solution (approximately 1000 micrograms (gg) Ag per gram (g)) was applied to approximately 4 pairs of American Fiber and Finishing from NC, Albemarle by pipetting the solution. X4 leaf 100% nylon woven sheet (SR-823-32x28, 60 gsm) to saturate the " mesh contained in the polystyrene tray. About one gram of the coating solution was dropped from the mesh before the wire was hung in the oven for drying. Some other solutions were dropped from the mesh in an oven (estimated to be 1 g). Coating the mesh in a forced air oven (Memmert (Universal Oven, from Wisconsin Oven Company, East Troy)

Wisconsin is available for drying by heating at 80 ° C for 12 minutes. The resulting material was white in appearance after drying. These coated samples are coated in aluminum foil in an environment of about 20-30% relative humidity (protected from light) and exposed to fluorescent lamps (Philips, F32T8/TL735, Universal/Hi-Vision, E4) , or exposed to fluorescent light (Philips, F32T8/TL735, Universal/Hi-Vision, K4) in an environment of 45-50% relative humidity. The color of these samples over time was measured using a Minolta Chroma Meter (CR-300, manufactured by Konica Minolta Photo Imaging U.S.A., Inc., Mahwah, NJ) 125842.doc -36-200826950. The results are shown in Table ι. Table 1-1 Example 1-1 Color exposure time with time (hr) Relative humidity (%RH) Exposure condition CIE tristimulus value XYZ 0 28% 90.46 92.38 104.24 2 28% in foil 90.35 92.27 103.81 in foil 28% in foil 90.25 92.18 104.13 8 28% in foil 90.74 92.66 104.54 24 28% in foil 89.14 91.07 102.49 0 28% exposure 89.86 91.83 102.38 2 28% exposure 87.31 89.10 99.42 4 28% exposure 87.33 89.04 98.99 8 28% Exposure 85.79 87.36 95.76 24 28% Exposure 80.39 81.67 87.63 0 50% Exposure 89.75 91.67 102.80 2 50% Exposure 85.72 87.38 97.79 4 50% Exposure 84.75 86.29 96.40 8 50% Exposure 82.21 83.64 92.39 24 50% Exposure 74.65 75.76 79.76 实例 Example 1- 2

The silver solution was silver benzoate (Alfa Aesar; Ward Hill, ΜΑ) and the solution was prepared by placing 0.459 g of silver benzoate and 200 g of distilled water in a glass bottle in the same manner as in Example 1-1. To prepare samples. The resulting silver benzoate solution was about 1000 pg Ag/g. The color of the sample is white. The results from the color monitoring experiments are shown in Table 1-2. Table 1-2 Example 1-2 Color exposure time over time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% in foil 90.39 92.35 103.28 125842.doc -37- 200826950 2 28% In the foil 89.81 91.79 102.56 4 28% in the foil 89.51 91.40 103.01 8 28% in the foil 90.78 92.73 102.80 24 28% in the foil 87.44 89.39 98.96 0 28% exposure 89.71 91.72 101.82 2 28% exposure 86.34 88.18 97.11 4 28% Exposure 82.12 83.79 91.43 8 28% Exposure 82.40 83.91 88.86 24 28% Exposure 75.94 77.12 78.34 0 50% Exposure 89.27 91.23 100.30 2 50% Exposure 83.27 84.98 92.34 4 50% Exposure 81.03 82.47 87.90 8 50% Exposure 79.02 80.33 82.68 24 50% Exposure 67.65 68.40 65.26 Example Ι·3 (Comparative) The color grade of a commercially available wound dressing over time during exposure to light is also measured. This commercially available wound dressing from ConvaTec's trademark AQUALCEL Ag, 匕5F055 19 contains silver chloride/silver alginate (a vapor with a high content of a stabilizer) and has an initial color of off-white. The sample color was significantly grayed during exposure to light. The results from these experiments are shown in Tables 1-3. Table 1-3 Examples 1-3 (comparative) Color exposure time with time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 12% in foil 53.51 53.75 64.21 2 12% in foil 53.03 53.30 63.85 4 11% in foil 52.90 53.22 63.91 8 12% in foil 53.40 53.73 64.41 24 11% in foil 53.53 53.66 64.44 48 10% exposure 53.41 53.74 64.57 125842.doc -38- 200826950 120 16% exposure 52.31 52.61 63.28 168 18% exposure 52.67 53.01 63.60 0 12% exposure 51.75 52.09 62.71 2 12% exposure 47.28 47.81 57.76 4 11% exposure 46.20 46.58 55.52 8 12% exposure 44.79 45.29 53.37 24 11% exposure 43.30 43.60 50.25 48 10% exposure 41.44 41.67 47.11 120 16% exposure 39.12 39.41 44.70 168 18% exposure 38.12 38.46 43.78 0 49% exposure 53.06 53.37 63.67 2 49% exposure 47.16 47.76 58.26 4 49% exposure 45.63 46.09 55.69 8 49% exposure 44.07 44.48 53.31 24 49% exposure 40.91 41.25 48.51 48 49 % exposure 38.62 38.85 44.85 120 49% exposure 36.54 36.49 41.75 168 49% exposure 34.53 34.42 39.59 Example 1-4 except for the matrix containing nitrocellulose and acetic acid The cellulose membrane filter (0.22 μΜ filter, GSWP 047 00, from the MA, Billerica of Millipore) than to the same manner as Example of Ι · 1 Samples were prepared. The initial color of the sample is white. The results from the color monitoring experiments are shown in Tables 1-4. Table Ι·4 Example Ι·4 Color exposure time with time (hr) Relative humidity (%RH) Exposure condition CIE tristimulus value XYZ 0 28% in foil 95.85 97.63 113.02 2 28% in foil 95.87 97.65 113.33 4 28% in foil 95.72 97.49 112.31 125842.doc •39- 200826950 8 28% in foil 96.16 97.92 113.55 24 28% in foil 95.41 97.16 112.52 0 28% exposure 95.39 97.16 110.68 2 28% exposure 93.85 95.30 108.41 4 28% Exposure 93.08 94.36 107.35 8 28% Exposure 90.68 91.51 102.44 24 28% Exposure 82.39 82.56 88.25 0 50% Exposure 96.78 98.66 114.99 2 50% Exposure 95.51 97.18 113.02 4 50% Exposure 93.73 95.04 109.09 8 50% Exposure 88.85 89.71 97.77 24 50% Exposure 75.61 76.06 73.34 Examples 1-5 Except for the membrane filter containing nitrocellulose and cellulose acetate (0.22 μΜ filter, GSWP 047 00, from Millipore, MA, Billerica), as in Example 1-2 Samples were prepared in the same manner. The initial color of the sample is white. The results from the color monitoring experiments are shown in Tables 1-5. Table 1-5 Example Ι·5 Color exposure time with time (hr) Relative humidity (%RH) Exposure condition CIE tristimulus value XYZ 0 28% 93.47 95.19 106.56 2 28% in foil 93.23 94.91 106.02 in foil 28% in foil 93.33 95.04 106.05 8 28% in foil 93.59 95.31 106.54 24 28% in foil 93.98 95.83 108.01 0 28% exposure 94.54 96.26 109.36 2 28% exposure 94.84 96.63 109.90 4 28% exposure 94.71 96.41 109.77 8 28% Exposure 94.25 96.01 108.22 125842.doc -40- 200826950 24 28% Exposure 92.18 94.04 104.00 0 50% Exposure 95.32 97.09 111.53 2 50% Exposure 94.48 96.22 109.14 4 50% Exposure 94.41 96.08 108.78 8 50% Exposure 92.65 94.40 103.59 24 50% Exposure 89.57 91.64 96.76 Examples 1-6 except that the substrate is from 100% polystyrene spunlace (SONTARA 8010, 45 gsm) from I. du Pont de Nemours and Company, DE, Wilmington, as in Example 1. Samples were prepared in the same manner as -1. The polyester nonwoven is wetted by mechanically introducing the silver nitrate solution into the pores of the polyester substrate by the fingertips of the glove-covered hand. (The glove is SAFESKIN powder-free lacnitase-checking glove (Ref 55083 Large) manufactured by GA, Roswell, Kimberly Clark). The initial color of the sample is white. The results from the color monitoring experiments are shown in Tables 1-6. Table 1-6 Examples 1-6 Color exposure time with time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% Exposure 90.47 92.32 104.25 2 28% Exposure 89.24 90.87 102.19 4 28% Exposure 88.14 89.48 99.82 6 28% Exposure 86.47 87.58 96.84 7.5 28% Exposure 84.43 85.31 93.62 11.25 28% Exposure 83.32 83.98 90.67 29 28% Exposure 76.87 77.16 80.76 0 50% Exposure 88.14 89.48 99.82 2 50% Exposure 85.21 86.09 94.70 3.5 50% Exposure 84.14 84.87 92.88 6 50% exposure 80.86 81.25 87.39 125842.doc • 41 - 200826950 23 50% exposure 75.47 75.78 79.89 Example 1-7 In addition to the preparation of silver nitrate solution by placing 1.261 g of silver nitrate and 200 g of distilled water in a glass bottle, Samples were prepared in the same manner as in Examples 1-6. The resulting silver nitrate solution was about 4000 pg Ag/g. The initial color of the sample is white. The results from the color monitoring experiments are shown in Tables 1-7. Table 1-7 Example 1-7 Color exposure time over time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% Exposure 91.49 93.40 106.76 2 28% Exposure 90.99 92.76 106.14 4 28% Exposure 90.10 91.76 104.65 6 28% Exposure 88.57 90.09 100.83 7.5 28% Exposure 88.55 90.04 101.03 11.25 28% Exposure 88.39 89.79 99.84 29 28% Exposure 85.29 86.53 95.58 0 50% Exposure 90.10 91.76 104.65 2 50% Exposure 88.42 89.94 101.41 3.5 50% Exposure 87.29 88.72 99.64 6 50% exposure 86.94 88.14 98.10 23 50% exposure 82.71 83.72 91.35 Example Ι·8 (comparative) The matrix is a 100% cotton non-woven fabric from Nippon Suntec Union (Nissinbo, AN20601050 60 gsm, containing less than 50 ppm gas) A sample was prepared in the same manner as in Example 1-1 except for the compound. The initial color of the sample is grayish white. The results from the color monitoring experiments are shown in Table 1-8. Table 1-8 Examples 1-8 (Comparative) Color over time 125842.doc -42- 200826950 Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% in foil 90.11 92.05 103.38 2 28% in foil 88.36 90.24 100.54 4 28% in foil 89.33 91.28 101.61 8 28% in foil 89.45 91.36 101.37 24 28% in the box 87.69 89.60 98.82 0 28% Exposure 89.91 91.83 102.77 2 28% Exposure 81.82 82.87 91.87 4 28% Exposure 74.05 74.31 81.64 8 28% Exposure 64.83 64.22 67.01 24 28% Exposure 44.04 43.82 45.43 0 50% Exposure 91.11 93.06 105.01 2 50% Exposure 84.35 85.39 94.23 4 50% exposure 76.12 76.24 81.43 8 50% exposure 57.88 56.99 57.51 24 50% exposure 36.17 36.59 35.92 Examples 1-9 (comparative) The matrix is 100% cotton non-woven from Nippon Suntec Union (Nissinbo, AN20601050 60 gsm, Samples were prepared in the same manner as in Examples 1-2, except that less than 50 ppm of chloride was used. The initial color of the sample is grayish white. The results from the color monitoring experiments are shown in Table 1-9. Table 1-9 Examples 1-9 (Comparative) Color exposure time over time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% in the foil 88.51 90.40 98.82 2 28% in the foil 87.96 89.84 97.60 4 28% in the foil 88.26 90.13 97.57 8 28% in the foil 88.29 90.18 97.03 125842.doc -43- 200826950 24 28% in the foil 86.37 88.27 93.35 0 28% Exposure 90.06 91.99 102.55 2 28% Exposure 86.96 88.49 97.45 4 28% Exposure 83.47 84.56 92.26 8 28% Exposure 75.28 75.27 79.70 24 28% Exposure 54.60 54.14 56.55 0 50% Exposure 88.58 90.47 99.23 2 50% Exposure 82.85 83.98 90.29 4 50% exposure 75.59 75.77 81.13 8 50% exposure 60.09 59.35 62.85 24 50% exposure 34.42 35.74 37.87 Example Ι·10 (comparative) In addition to the substrate is 70% of the silk from the FA~MA JERSEY spa in Italy / 30% PET fiber Samples were prepared in the same manner as in Example 1-1 except for the woven fabric (507030RPET PI, white, 50 gsm). The initial color of the sample is off-white. The results from the color monitoring experiments are shown in Tables 1-10. Table 1-10 Examples 1-10 (comparative) Color exposure time with time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% in the foil 81.37 82.74 86.19 2 28% in the foil 80.15 81.31 84.22 4 28% in foil 81.30 82.52 86.23 8 28% in foil 80.10 81.18 84.08 24 28% in foil 78.68 79.73 82.21 0 28% exposure 84.09 85.69 90.95 2 28% exposure 40.47 41.03 45.52 4 28% exposure 34.16 34.53 38.44 8 28% exposure 27.04 27.02 29.61 24 28% exposure 22.53 22.32 23.17 0 50% exposure 83.47 84.96 88.89 2 50% exposure 36.60 36.75 40.03 125842.doc -44- 200826950 4 50% exposure 30.65 30.61 33.06 8 50% exposure 24.80 24.51 24.75 24 50% exposure 19.87 19.56 16.79 Examples 1-11 (comparative) The substrate was 70 °/ from the FA~MA JERSEY spa from Italy. Samples were prepared in the same manner as in Example 1-2 except for the human silk / 30% PET fiber non-woven fabric (507030RPET P1, white, 50 gsm). The initial color of the sample is off-white. The results from the color monitoring experiments are shown in Table 1-1 1. Table 1-11 Example Ι·11 (comparative) Color exposure time with time (hr) Relative humidity (%RH) Exposure condition CIE tristimulus value XYZ 0 28% in foil 83.81 85.50 89.18 2 28% in foil 83.26 84.89 88.50 4 28% in foil 83.92 85.59 89.66 8 28% in foil 82.67 84.25 87.58 24 28% in foil 81.72 83.42 86.21 0 28% exposure 85.94 87.80 92.68 2 28% exposure 50.71 51.40 58.32 4 28% exposure 42.69 43.07 48.42 8 28% exposure 32.40 31.80 33.98 24 28% exposure 24.65 24.29 24.94 0 50% exposure 84.83 86.65 90.38 2 50% exposure 45.73 46.53 51.53 4 50% exposure 37.08 37.04 39.38 8 50% exposure 28.42 27.50 26.63 24 50% exposure 19.13 17.95 14.25 Examples 1-12 (Comparative) The substrate is 70% lysed fiber/30% PET containing less than 40 ppm of chloride from Ahlstrom Green Bay, Inc. of Green Bay, WI, WI, 125842.doc -45-200826950 woven (SX Samples were prepared in the same manner as in Example 1-1 except that -156, white, 50 gsm, FT-10 opening. The initial color of the sample is gray. The results from the color monitoring experiments are shown in Table M2. Table 1-12 Examples 1-12 (comparative) Color exposure time over time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value XYZ 0 28% in foil 82.78 83.66 90.59 2 28% in foil 82.40 83.23 90.07 4 28% in foil 82.70 83.49 90.27 8 28% in foil 82.50 83.21 89.90 24 28% in foil 80.46 81.05 87.50 0 28% exposure 84.02 85.04 91.42 2 28% exposure 41.48 41.60 46.75 4 28% exposure 32.67 32.97 38.11 8 28% exposure 28.61 29.01 33.61 24 28% exposure 23.99 24.36 28.34 0 50% exposure 84.96 86.10 93.01 2 50% exposure 40.73 40.84 46.51 4 50% exposure 33.88 34.04 39.12 8 50% exposure 29.17 29.43 33.70 24 50% exposure 25.38 25.52 27.80

II Example II-1 by 0. 0792 g silver sulphuric acid (Aldrich Chemical Co.) A silver nitrate coating solution was prepared by placing a 200 ml distilled water in a glass bottle and capping it and mixing it overnight in an shaker at room temperature. About 6 grams of this silver nitrate solution (about 250 pg Ag/g) was applied to 125842 from about 4忖χ4忖 of Suntec Union, by transferring the solution with a pipette. Doc •46- 200826950 100% cotton non-woven sheet (Nissinbo, AN20601050 60 gsm, containing less than 50 ppm chloride) to saturate the mesh contained in the polystyrene tray. About one gram of the coating solution was dropped from the mesh before the mesh was suspended in an oven for drying. Some additional solution was dripped from the mesh in an oven (estimated to be 1 g). The coated mesh was dried in a forced air oven (Memmert Universal Oven, available from Wisconsin Oven Company, East Troy Wisconsin) by heating at 105 °C for 12 minutes. The resulting material was white in appearance after drying. These coated samples were coated in aluminum foil in an environment of about 10-20% relative humidity (protected from light) and exposed to fluorescent lamps (Philips, F32T8/TL735, Universal/Hi-Vision, E4) Or exposed to fluorescent light in an environment of 45-50% relative humidity (Philips, F32T8/TL735, Universal/Hi-Vision, K4). Use Minolta Chroma Meter (CR-300, by Konica Minolta Photo Imaging U. S. A. , Inc., Mahwah, NJ) Measure the color grade of these samples over time. The results are shown in Table II-1. After the color stability test is completed, the analysis is at 10-20 ° /. Silver ions released from the sample protected in the foil and exposed to the fluorescent lamp at relative humidity. Silver release from the above sample was measured in a solution of distilled water and sodium nitrate using a silver ion selective electrode (Orion, available from VWR International, Batavia, IL). 0. 1341 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. Within 30 minutes of 96 grams of 5M sodium nitrate, 0 grams per gram of sample is released. 45 mg silver ion. In comparison, 0. 1140 g of the sample stored in the foil during the 168 hour period was released per gram of sample. 23 mg silver ion to 98 g distilled water and 2. 96 125842. Doc -47- 200826950 grams of sodium nitrate. Total silver content was also measured in duplicate on coated samples stored in pigs. For silver content, the sample is first decomposed using tannic acid and hydrogen peroxide (see EPA Method 6010), and then inductively coupled plasma-atomic emission spectroscopy (ICP-AES; Varian, Vista-Pro, ΑΧ)) Measure the total amount of silver. The average silver content was 1700 mg Ag/kg sample. Silver metal analysis was carried out by first extracting the sample overnight at room temperature with a 2.8% (w/w) ammonium carbonate solution. The leaching solution was then removed and the sample was broken down as above and the silver content was determined. For samples stored in foil, the sample has a silver metal content of 120 mg/kg sample. Table II-1 Example II-1 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 87. 06 89. 1 94. 7 2 12% in foil 87. 72 89. 78 95. 72 4 11% in foil 87. 64 89. 71 95. 25 8 12% in foil 87. 48 89. 55 95. 18 24 11% in foil 87. 88 89. 96 95. 82 48 10% in the box 88. 22 90. 26 96. 36 120 16% in foil 87. 86 89. 92 95. 7 168 18% in the box 87. 23 89. 32 94. 6 0 12% exposure 86. 35 88. 3 92. 01 2 12% exposure 86. 04 87. 89 92. 59 4 11% exposure 85. 94 84. 68 92. 96 8 12% exposure 84. 49 86. 08 91. 04 24 11% exposure 82. 21 83. 44 88. 22 48 10% exposure 77. 79 78. 39 82. 1 120 16% exposure 68. 61 69. 08 71. 7 168 18% exposure 65. 85 66. 99 68. 05 125842. Doc -48 - 200826950 0 49% exposure 86. 51 88. 49 92. 2 2 49% exposure 86. 08 87. 89 92. 25 4 49% exposure 84. 66 86. 1 90. 86 8 48% exposure 78. 49 79. 18 81. 62 24 47% exposure 59. 77 60. 04 61. 67 48 47% exposure 47. 43 48. 48 49. 18 120 47% exposure 39. 56 40. 73 36. 79 168 47% exposure 36. 64 37. 83 33. 51 Example II-2 (Control) The color of the uncoated cotton substrate used in Example II-1 was also measured over time ('Grade. These results are included in Table II-2. Table II-2 Examples 11-2 (control) color exposure time over time (hr) relative humidity (%RH) exposure condition CIE tristimulus value XYZ 0 12% in foil 92. 55 94. 58 107. 96 2 12% in foil 92. 55 94. 53 107. 93 4 11% in the box 92. 42 94. 37 107. 9 8 12% in foil 92. 57 94. 54 108. 2 24 11% in foil 92. 53 94. 54 107. 99 48 10% in foil 92. 85 94. 83 108. 54 120 16% in foil 92. 9 94. 88 108. 61 168 18% in foil 92. 6 94. 65 108. 2 Example 11-3 (Comparative) The color grade of a commercially available wound dressing over time during exposure to light was also measured. A commercially available wound dressing from ConvaTec under the trademark AQUACEL Ag, Lot 5F055 19 contains silver halide/silver alginate (having a high content of chloride acting as a stabilizer) and has an initial color of off-white. 125842. Doc •49· 200826950 The color of the sample is significantly grayed out during exposure to light. The results from these experiments are shown in Table II-3. Table II-3 Example 11-3 (Comparative) Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 53. 51 53. 75 64. 21 2 12% in foil 53. 03 53. 30 63. 85 4 11% in foil 52. 90 53. 22 63. 91 8 12% in foil 53. 40 53. 73 64. 41 24 11% in foil 53. 53 53. 66 64. 44 48 10% in foil 53. 41 53. 74 64. 57 120 16% in foil 52. 31 52. 61 63. 28 168 18% in foil 52. 67 53. 01 63. 60 0 12% exposure 51. 75 52. 09 62. 71 2 12% exposure 47. 28 47. 81 57. 76 4 11% exposure 46. 20 46. 58 55. 52 8 12% exposure 44. 79 45. 29 53. 37 24 11% exposure 43. 30 43. 60 50. 25 48 10% exposure 41. 44 41. 67 47. 11 120 16% exposure 39. 12 39. 41 44. 70 168 18% exposure 38. 12 38. 46 43. 78 0 49% exposure 53. 06 53. 37 63. 67 2 49% exposure 47. 16 47. 76 58. 26 4 49% exposure 45. 63 46. 09 55. 69 8 48% exposure 44. 07 44. 48 53. 31 24 47% exposure 40. 91 41. 25 48. 51 48 47% exposure 38. 62 38. 85 44. 85 120 47% exposure 36. 54 36. 49 41. 75 168 47% exposure 34. 53 34. 42 39. 59 Example II-4 except by 0. 316 g of silver nitrate and 200 g of distilled water were placed in a glass bottle to 125842. Doc -50- 200826950 In addition to the preparation of the silver nitrate solution, samples were prepared in the same manner as in the example π-l. The resulting silver acid solution was about 1000 (ig Ag/g. The sample color was off-white. The results from the color monitoring experiments are shown in Table II-4. Silver ion release and total were performed as described in Example II-1. Silver content measurement. A sample of 1320 g exposed to light at 168 hr at about 20% relative humidity was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 46 mg silver ion. In comparison, 0. 1626 g Samples stored in foil were released per gram of sample during 168 hours. 21 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 6950 mg Ag/kg sample. The silver metal content was 350 mg/kg sample. Table II-4 Example 11_4 color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 80. 95 82. 71 80. 89 2 12% in foil 80. 80 82. 54 80. 47 4 11% in foil 81. 81 83. 56 81. 88 8 12% in foil 81. 12 82. 82 80. 73 24 11% in foil 81. 23 82. 93 80. 77 48 10% in foil 81. 15 82. 85 80. 58 120 16% in foil 81. 01 82. 7 80. 37 168 18% in foil 80. 82 82. 51 79. 83 0 12% exposure 81. 13 82. 87 82. 42 2 12% exposure 81. 07 82. 79 81. 84 4 11% exposure 80. 91 82. 53 82. 16 8 12% exposure 79. 77 81. 24 80. 65 24 11% exposure 77. 4 78. 46 75. 52 48 10% exposure 72. 71 73. 19 68. 73 125842. Doc -51- 200826950 120 16% exposure 60. 66 60. 53 53. 36 168 18% exposure 51. 71 51. 63 44. 89 0 49% exposure 81. 53 83. 26 81. 2 2 49% exposure 79. 98 81. 49 78. 29 4 49% exposure 78. 76 80. 02 76. 25 8 48% exposure 75. 06 75. 86 71. 43 24 47% exposure 59. 73 60. 29 55. 57 48 47% exposure 48. 01 48. 98 43. 13 120 47% exposure 30. 68 30. 97 20. 96 168 47% exposure 27. 78 27. 99 18. 12 Example Π-5 A sample was prepared in the same manner as in Example Π-1 except that the drying temperature was 130 °C. The sample color is milky yellow (light yellow). The results from the color monitoring experiments are shown in Table-5. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1341 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 49 mg silver ion. In comparison, 0. 1280 g of sample stored in foil was released per gram of sample during 168 hours. 06 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content is 2000 mg Ag/kg sample. The silver metal content was 160 mg/kg sample. Table 11-5 0 Example II-5 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 69. 49 70. 83 48. 26 2 12% in foil 70. 01 71. 37 48. 99 4 11% in foil 69. 90 71. 23 48. 73 125842. Doc -52· 200826950 8 12% in foil 69. 32 70. 57 47. 78 24 11% in foil 69. 76 71. 02 48. 57 48 10% in foil 69. 68 70. 92 48. 05 120 16% in foil 69. 53 70. 73 48. 18 168 18% in foil 69. 56 70. 83 48. 09 0 12% exposure 69. 00 70. 17 48. 40 2 12% exposure 68. 53 69. 63 48. 37 4 11% exposure 68. 82 69. 91 48. 72 8 12% exposure 67. 16 68. 08 46. 75 24 11% exposure 65. 74 66. 32 45. 88 48 10% exposure 63. 61 63. 80 44. 50 120 16% exposure 55. 74 55. 41 38. 01 168 18% exposure 50. 82 50. 69 35. 80 0 49% exposure 68. 68 69. 72 50. 85 2 49% exposure 66. 61 67. 34 47. 24 4 49% exposure 65. 34 65. 81 45. 74 8 48% exposure 62. 47 62. 50 44. 00 24 47% exposure 51. 69 50. 97 37. 77 48 47% exposure 41. 88 42. 00 33. 19 120 47% exposure 35. 46 36. 24 28. 98 168 47% exposure 31. 18 31. 89 26. 85 Example II-6 A sample was prepared in the same manner as in Example ΙΙ-4 except that the drying temperature was 130 °C. The sample color is light yellow. The results from the color monitoring experiments are shown in Table -6. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1376 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 28 mg silver ion. In comparison, 0. 1462 grams of sample stored in foil during the 168 hour period per gram sample 125842. Doc -53- 200826950 Product release 5. 18 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 7650 mg Ag/kg sample. The silver metal content was 530 mg/kg sample. Table II-6 Example II-6 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 55. 09 54. 35 32. 83 2 12% in foil 54. 89 54. 13 32. 89 4 11% in foil 55. 37 54. 65 33. 23 8 12% in foil 54. 72 53. 98 32. 83 24 11% in foil 55. 50 54. 77 33. 61 48 10% in the box 55. 83 55. 14 33. 67 120 16% in foil 56. 72 56. 16 34. 03 168 18% in foil 55. 71 55. 05 33. 62 0 12% exposure 57. 41 57. 16 36. 86 2 12% exposure 57. 39 57. 18 37. 32 4 11% exposure 58. 53 58. 32 37. 92 8 12% exposure 56. 98 56. 66 36. 61 24 11% exposure 56. 42 55. 93 35. 89 48 10% exposure 54. 61 53. 86 33. 79 120 16% exposure 50. 06 48. 96 30. 27 168 18% exposure 45. 73 44. 54 27. 05 0 49% exposure 55. 70 54. 92 32. 57 2 49% exposure 55. 72 54. 96 31. 58 4 49% exposure 54. 78 53. 85 30. 23 8 48% exposure 53. 14 52. 06 29. 52 24 47% exposure 48. 62 47. 21 25. 68 48 47% exposure 39. 26 38. 29 21. 27 120 47% exposure 26. 10 24. 96 14. 83 168 47% exposure 23. 89 22. 17 11. 66 Example II-7 125842. Doc -54- 200826950 A sample was prepared in the same manner as in Example Π-1 except that the drying temperature was 155 °C. The sample color is yellow. The results from the color monitoring experiments are shown in Tables II-7. Silver ion release and total silver content measurements were performed as described in Example II-1. A sample of 0. 1426 grams exposed to light at about 20% relative humidity for 168 hr was placed in 98 grams of distilled water and 2. 96 grams of 5M sodium nitrate in 96 grams per kilogram of sample release. 31 mg silver ion. In comparison, 0. 1307 g of the sample stored in foil released 0 per gram of sample during 168 hours. 95 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 1850 mg Ag/kg sample. The silver metal content was 250 mg/kg sample. Table II-7 Example II-7 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 57. 24 57. 13 28. 24 2 12% in foil 56. 37 56. 15 27. 74 4 11% in foil 59. 84 60. 15 30. 51 8 12% in foil 59. 49 59. 72 30. 29 24 11% in foil 59. 78 60. 01 30. 63 48 10% in foil 58. 90 59. 02 29. 69 120 16% in foil 59. 27 59. 34 30. 30 168 18% in foil 60. 24 60. 47 31. 04 0 12% exposure 55. 48 55. 08 28. 47 2 12% exposure 55. 62 55. 20 28. 86 4 11% exposure 55. 59 55. 09 28. 40 8 12% exposure 55. 11 54. 60 28. 20 24 11% exposure 53. 33 52. 59 27. 03 48 10% exposure 53. 40 52. 66 27. 73 125842. Doc -55- 200826950 120 16% exposure 50. 43 49. 57 26. 12 168 18% exposure 46. 73 45. 74 23. 78 0 49% exposure 59. 25 59. 66 33. 23 2 49% exposure 58. 72 58. 97 32. 67 4 49% exposure 58. 63 58. 92 32. 40 8 48% exposure 57. 94 58. 22 31. 47 24 47% exposure 55. 49 55. 46 30. 25 48 47% exposure 53. 18 53. 3 28. 88 120 47% exposure 45. 51 45. 67 26. 09 168 47% exposure 39. 02 39. 03 25. 11 Example II-8 A sample was prepared in the same manner as in Example ΙΙ-4 except that the drying temperature was 155 °C. The sample color is yellow. The results from the color monitoring experiments are shown in Table -8. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1366 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 49 mg silver ion. In comparison, 0. 1351 g of sample stored in foil was released per gram of sample during 168 hours. 97 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 6900 mg Ag/kg sample. The silver metal content was 900 mg/kg sample. Table II-8 Example II-8 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 42. 65 41. 24 19. 00 2 12% in foil 42. 95 41. 49 18. 57 4 11% in foil 43. 07 41. 59 18. 71 125842. Doc -56- 200826950 8 12% in foil 43. 22 41. 73 19. 15 24 11% in foil 43. 25 41. 76 18. 85 48 10% in foil 43. 40 41. 90 19. 05 120 16% in foil 43. 98 42. 50 19. 43 168 18% in foil 43. 88 42. 40 19. 27 0 12% exposure 43. 55 45. 33 18. 81 2 12% exposure 44. 10 42. 86 19. 08 4 11% exposure 43. 80 42. 56 18. 89 8 12% exposure 43. 29 41. 99 18. 44 24 11% exposure 42. 88 41. 53 18. 91 48 10% exposure 42. 11 40. 70 17. 65 120 16% exposure 39. 80 38. 31 16. 75 168 18% exposure 36. 54 35. 29 16. 27 0 49% exposure 42. 34 40. 96 18. 32 2 49% exposure 43. 11 41. 64 17. 39 4 49% exposure 42. 19 40. 68 17. 74 8 48% exposure 41. 40 39. 90 17. 04 24 47% exposure 38. 31 36. 62 16. 24 48 47% exposure 33. 94 32. 50 13. 97 120 47% exposure 26. 01 24. 71 10. 66 168 47% exposure 23. 28 21. 99 10. 32 Example II-9 except by 0. Samples were prepared in the same manner as in Example 11_8 except that 632 g of silver nitrate and 200 g of distilled water were placed in a glass bottle to prepare a silver nitrate solution. The resulting silver nitrate solution was about 2000 pg Ag/g. The sample color is golden yellow. The results from the color monitoring experiments are shown in Tables II-9. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1308 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 2 mg silver ion. In comparison, 125842. Doc -57- 200826950 0. 1431 g Samples stored in foil were released per gram of sample during 168 hours. 8 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content is 16,000 mg Ag/kg sample. Silver metal content is 1400 mg/kg sample ° Table II-9 Example II-9 color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 41. 74 40. 74 19. 36 2 12% in foil 41. 63 40. 58 19. 29 4 11% in foil 41. 48 40. 54 19. 99 8 12% in foil 42. 00 40. 91 19. 51 24 11% in foil 42. 41 41. 35 19. 55 48 10% in foil 42. 21 41. 18 19. 83 120 16% in foil 42. 31 41. 29 19. 98 168 18% in foil 42. 98 41. 99 20. 03 0 12% exposure 40. 59 39. 38 18. 64 2 12% exposure 40. 89 39. 71 19. 49 4 11% exposure 40. 95 39. 76 20. 07 8 12% exposure 40. 05 38. 84 19. 99 24 11% exposure 40. 65 39. 33 18. 52 48 10% exposure 40. 20 38. 89 18. 66 120 16% exposure 38. 79 37. 25 16. 35 168 18% exposure 36. 05 34. 41 16. 96 0 49% exposure 40. 24 39. 12 19. 14 2 49% exposure 40. 54 39. 19 17. 30 4 49% exposure 41. 31 40. 15 18. 37 8 48% exposure 40. 61 39. 35 17. 70 24 47% exposure 38. 43 36. 78 15. 89 48 47% exposure 34. 27 32. 43 13. 77 120 47% exposure 24. 06 21. 72 10. 56 168 47% exposure 21. 06 18. 68 9. 53 125842. Doc -58- 200826950 Example Π10 The silver removal solution is silver benzoate (Alfa Aesar; Ward Hill, MA), which will be 0. Samples were prepared in the same manner as in Example -8, except that 230 g of silver benzoate and 200 g of distilled water were placed in a glass bottle. The resulting silver benzoate solution was about 5 GG μ Ag/g. The sample color is yellow. The results from the color 1 monitoring experiment are shown in Table - i 0. Silver ion release and total silver content measurements were performed as described in Example II-1. 〇·1341 g of the sample exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate in the 30 knives of the mother gram sample released 〇 · 22 silver ions. In comparison, 0. 1323 g of sample stored in foil released 0 per gram of sample during 168 hours. 71 mg of silver ion to 98 g of distilled water and 厶"g of sodium nitrate. The average total silver content is 3350 Ag / kg sample. Table II-10 Example II-10 color exposure time with time (hr) relative humidity (%RH) Exposure conditions CIE tristimulus value X γ z 0 12% in the foil 41. 83 41. 21 18. 15 2 12% in foil 42. 09 41. 5 18. 44 4 11% in foil 42. 19 41. 65 18 64 8 12% in foil 42. 27 41. 71 18 61 24 11% in foil 42. 27 41. 72 19 44 48 10% 42. 28 41 7 19 06 120 16% 42. 57 41 82 x y ·ν/V/ 18 63 168 18% 42 55 41 84 19 14 0 12% —ϋ 42 94 42 37 18 87 2 12% 42 19 41. 67 19 99 4 11% 42. 07 41. 57 19. 87 125842. Doc -59.  200826950 8 12% exposure 42. 27 41. 81 19. 65 24 11% exposure 42. 05 41. 6 19. 25 48 10% exposure 41. 78 41. 33 19. 82 120 16% exposure 42. 19 41. 68 20. 01 168 18% exposure 42. 12 41. 58 19. 92 0 49% exposure 41. 04 40. 65 19. 67 2 49% exposure 41. 85 41. 34 18. 70 4 49% exposure 40. 04 39. 42 19. 00 8 48% exposure 39. 79 39. 11 18. 73 24 47% exposure 39. 86 39. 11 18. 04 48 47% exposure 39. 21 38. 24 17. 61 120 47% exposure 38. 06 37. 14 17. 32 168 47% exposure 36. 47 35. 68 17. 83 Example π-ll The silver removal solution is silver benzoate and by 0. A sample was prepared in the same manner as in Example II-10 except that 459 g of silver benzoate and 200 g of distilled water were placed in a glass bottle to prepare this solution. The resulting silver benzoate solution was about 1 〇〇〇 Kg Ag/g. The sample color is yellow. The results from the color monitoring experiments are shown in Table-ll. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1352 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 80 mg silver ion. In comparison, 0. 1502 g of sample stored in foil was released per gram of sample during 168 hours. 50 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 6750 Ag/kg sample. Table Π-ll instance Π-ll color over time 125842. Doc -60- 200826950 Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in fl 31. 49 30. 33 13. 40 2 12% in foil 32. 21 31. 07 13. 62 4 11% in foil 32. 49 31. 36 13. 49 8 12% in foil 32. 37 31. 18 13. 72 24 11% in foil 32. 32 31. 14 13. 74 48 10% in foil 32. 44 31. 21 13. 46 120 16% in foil 32. 64 31. 38 13. 61 168 18% in foil 32. 36 31. 07 13. 82 0 12% exposure 32. 48 31. 33 13. 78 2 12% exposure 32. 21 31. 05 13. 34 4 11% exposure 32. 01 30. 85 13. 26 8 12% exposure 32. 30 31. 19 13. 56 24 11% exposure 31. 73 30. 64 13. 32 48 10% exposure 31. 63 30. 57 13. 56 120 16% exposure 31. 57 30. 43 13. 30 168 18% exposure 31. 69 30. 53 13. 37 0 49% exposure 33. 00 31. 91 13. 92 2 49% exposure 32. 78 31. 55 12. 98 4 49% exposure 32. 73 31. 47 13. 07 8 48% exposure 32. 31 31. 06 13. 34 24 47% exposure 32. 32 30. 94 12. 76 48 47% exposure 31. 23 29. 74 12. 45 120 47% exposure 29. 81 28. 41 11. 76 168 47% exposure 28. 60 27. 49 12. 22 Example II-12 except that the matrix is 100% TENCEL fiber non-woven fabric containing less than 40 ppm of vapor (SX-152, white, 65 gsm, 24 mesh, from Green Bay Nonwovens, Inc., WI, Green Bay). In addition, samples were prepared in the same manner as in Example II-11. The sample color is golden brown. Will come from 125842. Doc -61 - 200826950 The results of the color monitoring experiments are shown in Tables 11-12. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1662 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 61 mg silver ion. In comparison, 0. 1524 g of sample stored in foil was released per gram of sample during 168 hours. 34 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 7650 Ag/kg sample. Table II-12 Example II-12 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 22. 92 21. 10 6. 51 2 12% in foil 22. 88 21. 02 6. 43 4 11% in foil 22. 58 20. 73 6. 32 8 12% in foil 22. 94 21. 09 6. 35 24 11% in foil 22. 91 21. 06 6. 30 48 10% in foil 23. 00 21. 12 6. 26 120 16% in foil 22. 88 20. 96 6. 15 168 18% in foil 23. 60 21. 63 6. 52 0 12% exposure 22. 97 21. 26 6. 68 2 12% exposure 23. 83 22. 10 6. 68 4 11% exposure 24. 22 22. 52 6. 88 8 12% exposure 24. 08 22. 38 6. 82 24 11% exposure 24. 40 22. 75 6. 86 48 10% exposure 24. 26 22. 61 6. 83 120 16% exposure 23. 40 21. 79 6. 88 168 18% exposure 24. 39 22. 71 6. 88 0 49% exposure 23. 00 21. 19 6. 54 2 49% exposure 22. 42 20. 68 6. 19 125842. Doc -62- 200826950 4 49% exposure 21. 15 19. 56 6. 05 8 48% exposure 20. 44 19. 02 6. 13 24 47% exposure 18. 46 17. 48 6. 03 48 47% exposure 17. 00 16. 42 6. 06 120 47% exposure 15. 90 15. 79 6. 48 168 47% exposure 16. 04 16. 07 6. 91 Example II-13 A sample was prepared in the same manner as in Example ΙΙ-4 except that the drying temperature was 180 °C. The sample color is golden yellow. The results from the color monitoring experiments are shown in Tables 11-13. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1476 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 44 mg silver ion. In comparison, 0. 1550 g of the sample stored in foil released 0 per gram of sample during 168 hours. 88 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 6900 mg Ag/kg sample. The silver metal content was 1200 mg/kg sample. Table II-13 Example 11-13 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 30. 67 29. 37 9. 41 2 12% in foil 31. 03 29. 79 9. 95 4 11% in foil 31. 08 29. 83 9. 98 8 12% in foil 31. 09 29. 90 9. 90 24 11% in foil 31. 17 29. 92 9. 95 48 10% in the box 31. 10 29. 81 9. 88 120 16% in foil 31. 19 29. 81 9. 98 125842. Doc -63- 200826950 168 18% in foil 31. 24 29. 85 10. 07 0 12% exposure 30. 09 28. 75 10. 25 2 12% exposure 30. 34 28. 93 9. 95 4 11% exposure 30. 02 28. 60 10. 13 8 12% exposure 29. 49 28. 15 10. 48 24 11% exposure 29. 50 28. 11 10. 35 48 10% exposure 29. 38 28. 02 10. 58 120 16% exposure 29. 12 27. 95 10. 81 168 18% exposure 27. 98 26. 98 10. 64 0 49% exposure 33. 28 32. 32 11. 46 2 49% exposure 34. 46 33. 41 11. 48 4 49% exposure 34. 49 33. 44 11. 48 8 48% exposure 33. 89 32. 85 11. 26 24 47% exposure 33. 50 32. 57 11. 44 48 47% exposure 32. 46 31. 58 11. 08 120 47% exposure 30. 71 30. 02 10. 93 168 47% exposure 30. 15 29. 55 10. 82 Example II-14 The silver removal solution contains 0. 127 g of silver carbonate (Alfa Aesar, Ward Hill, MA), 0. Samples were prepared in the same manner as in Examples 11-10, except for 48 g of ammonium carbonate (Mallinckroft Baker, Inc.; Phillipsburg, NJ) and 100 g of distilled water. The color of the coated cotton sample is golden yellow. The results from the color monitoring experiments are shown in Tables II-14. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1386 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 44 mg silver ion. In comparison, 0. 1498 g of sample stored in foil released 0 per gram of sample during 168 hours. 48 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. 125842. Doc •64- 200826950 The average total silver content is 8150Ag/kg sample. Table II-14 Example II-14 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 34. 39 32. 41 12. 16 2 12% in foil 34. 87 33. 16 12. 96 4 11% in foil 34. 95 33. 32 13. 79 8 12% in foil 35. 40 33. 71 13. 74 24 11% in foil 34. 94 33. 01 12. 97 48 10% in foil 34. 48 32. 62 13. 61 120 16% in foil 34. 28 32. 23 13. 50 168 18% in foil 34. 30 31. 99 12. 57 0 12% exposure 31. 50 29. 39 10. 26 2 12% exposure 30. 83 28. 74 10. 04 4 11% exposure 32. 22 30. 21 10. 55 8 12% exposure 31. 59 29. 50 10. 23 24 11% exposure 31. 64 29. 44 10. 42 48 10% exposure 32. 02 29. 80 10. 32 120 16% exposure 31. 69 29. 43 10. 21 168 18% exposure 31. 98 29. 75 10. 22 0 49% exposure 30. 65 28. 7 10. 66 2 49% exposure 30. 23 28. 08 9. 90 4 49% exposure 30. 60 28. 47 10. 17 8 48% exposure 30. 41 28. 29 10. 15 24 47% exposure 30. 65 28. 61 10. 64 48 47% exposure 30. 88 28. 85 10. 31 120 47% exposure 30. 69 28. 68 10. 35 168 47% exposure 30. 80 28. 86 10. 35 Example II-15 The silver removal solution is silver acetate and by 0. 309 g of silver acetate (Matheson, Coleman and Bell; Norwood, OH) and 200 g of steamed water in a glass bottle 125842. A sample was prepared in the same manner as in Example Π-10 except that this solution was prepared in doc-65-200826950 and the drying temperature was 170 °C. The resulting silver acetate solution was about 1000 pg Ag/g. The sample color is yellow. The results from the color monitoring experiments are shown in Tables 11-15. Silver ion release measurements were performed as described in Example II-1. 0. A sample of 1525 g which was exposed to light for at least 14 days at about 20% relative humidity was placed in 98 grams of distilled water and 2. The release of 0 grams per gram of sample in 96 grams of 5M sodium nitrate in 30 minutes. 71 mg silver ion. In comparison, 0. 1528 g Samples stored in foil released 0 per gram of sample during the experiment. 69 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. Table 11-15 Examples 11-15 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 1 20% in foil 34. 89 33. 37 12. 36 9 18% in foil 31. 11 29. 48 12. 31 14 12% in foil 36. 99 35. 59 13. 20 17 14% in foil 35. 21 33. 93 14. 10 1 20% exposure 32. 48 31. 33 13. 78 9 18% exposure 32. 21 31. 05 13. 34 14 12% exposure 32. 01 30. 85 13. 26 17 14% exposure 32. 30 31. 19 13. 56 1 50% exposure 28. 56 26. 95 10. 11 9 50% exposure 28. 45 26. 90 10. 74 14 50% exposure 28. 14 26. 57 10. 22 17 50% exposure 27. 56 26. 15 11. 24 Example 11-16 except by 0. 632 g of silver nitrate and 200 g of distilled water were placed in a glass bottle to 125842. Doc-66-200826950 A sample was prepared in the same manner as in Example II-1 except that a silver nitrate solution was prepared. The resulting silver nitrate solution was about 2000 pg Ag/g. The sample color is grayish white. The results from the color monitoring experiments are shown in Table II.16. Silver ion release and total silver content measurements were performed as described in Example 11_1. 0. A sample of 1516 g exposed to light at 168 hr at about 20% relative humidity was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 6 mg silver ion. In comparison, 0. 13 68 g Samples stored in foil were released per gram of sample during 168 hours. 4 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 14000 mg Ag/kg sample. The silver metal content was 800 mg/kg sample. Table II-16 Example II-16 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 75. 30 76. 89 77. 09 2 12% in foil 75. 53 77. 17 77. 28 4 11% in foil 75. 87 77. 46 77. 74 8 12% in foil 75. 16 76. 77 77. 10 24 11% in foil 76. 30 77. 97 78. 73 48 10% in foil 75. 58 77. 21 77. 59 120 16% in foil 75. 33 76. 89 77. 04 168 18% in foil 75. 80 77. 43 77. 55 0 12% exposure 78. 27 79. 89 77. 61 2 12% exposure 78. 33 80. 04 79. 92 4 11% exposure 78. 53 80. 12 79. 39 8 12% exposure 79. 66 81. 14 80. 07 24 11% exposure 74. 36 75. 23 71. 10 48 10% exposure 73. 10 73. 56 70. 26 125842. Doc -67- 200826950 120 16% exposure 58. 89 59. 01 52. 31 168 18% exposure 52. 66 52. 83 45. 66 0 49% exposure 74. 12 75. 65 75. 08 2 49% exposure 72. 31 73. 65 71. 54 4 49% exposure 70. 98 71. 96 69. 21 8 48% exposure 67. 24 67. 78 64. 11 24 47% exposure 52. 12 52. 61 49. 25 48 47% exposure 38. 39 39. 49 36. 00 120 47% exposure 25. 21 25. 63 19. 53 168 47% exposure 22. 44 22. 83 16. 78 Example II-17 except by 1. A sample was prepared in the same manner as in Example II-1 except that 261 g of silver nitrate and 200 g of distilled water were placed in a glass bottle to prepare a silver nitrate solution. The resulting silver nitrate solution was about 4000 micrograms (pg) Ag per gram (g). The color of the sample is initially grayish white and produces a gray area (spotted) when exposed to light. The results from the color monitoring experiments are shown in Table II-1. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1360 g exposed to light at 168 hr at about 20% relative humidity was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released in 35 minutes per gram of sample. 35 mg silver ion. In comparison, 0. The 1211 g sample stored in foil was released per gram of sample during 168 hours. 37 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 28,500 mg Ag/kg sample. The silver metal content was 1400 mg/kg sample. Table II-17 Example II· 17 color over time 125842. Doc -68 · 200826950 Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 73. 87 75. 46 77. 48 2 12% in foil 74. 13 75. 74 73. 98 4 11% in the box 73. 94 75. 51 73. 60 8 12% in foil 74. 10 75. 70 74. 11 24 11% in foil 72. 79 74. 40 72. 92 48 10% in foil 73. 89 75. 53 74. 38 120 16% in foil 73. 97 75. 47 73. 60 168 18% in foil 73. 62 75. 24 73. 63 0 12% exposure 78. 92 80. 55 78. 70 2 12% exposure 78. 39 79. 88 78. 74 4 11% exposure 77. 15 78. 53 78. 78 8 12% exposure 75. 16 76. 30 76. 56 24 11% exposure 70. 52 70. 80 68. 93 48 10% exposure 61. 48 61. 39 61. 30 120 16% exposure 48. 40 48. 93 48. 63 168 18% exposure 40. 41 41. 29 38. 73 0 49% exposure 70. 91 72. 59 72. 84 2 49% exposure 68. 15 69. 45 64. 16 4 49% exposure 66. 20 67. 07 61. 32 8 48% exposure 59. 62 59. 83 54. 12 24 47% exposure 39. 81 40. 26 36. 05 48 47% exposure 29. 03 29. 81 25. 12 120 47% exposure 13. 65 13. 63 9. 97 168 47% exposure 11. 48 11. 34 8. 12 Example II-18 A sample was prepared in the same manner as in Example II-16 except that the drying temperature was 130 °C. The sample color is light yellow. The results from the color monitoring experiments are shown in Tables 11-18. Silver ion release and total silver content measurements were performed as described in Example II-1. 125842. Doc -69- 200826950 0. A sample of 1423 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 81 mg silver ion. In comparison, 0. 1411 g sample stored in foil per gram of sample during 168 hours * released 10. 36 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 13,000 mg Ag/kg sample. The silver metal content was 970 mg/kg sample. Table II-18 Example II-18 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 52. 98 52. 55 33. 91 2 12% in foil 53. 68 53. 29 34. 27 4 11% in foil 53. 97 53. 62 34. 95 8 12% in foil 53. 93 53. 55 34. 48 24 11% in foil 54. 27 53. 95 34. 88 48 10% in foil 54. 07 53. 70 34. 80 120 16% in foil 53. 75 53. 48 34. 58 168 18% in foil 54. 24 53. 96 35. 00 0 12% exposure 50. 45 49. 86 32. 06 2 12% exposure 50. 71 50. 18 32. 60 4 11% exposure 50. 68 50. 08 31. 95 8 12% exposure 50. 91 50. 25 31. 91 24 11% exposure 49. 39 48. 48 30. 70 48 10% exposure 45. 79 44. 69 28. 71 120 16% exposure 39. 41 38. 17 24. 11 168 18% exposure 33. 36 32. 65 22. 80 0 49% exposure 53. 06 52. 68 33. 77 2 49% exposure 53. 01 52. 53 32. 24 4 49% exposure 52. 24 51. 67 31. 74 8 48% exposure 50. 41 49. 52 29. 69 125842. Doc •70· 200826950 24 47% exposure 40. 06 39. 17 24. 68 48 47% exposure 31. 50 31. 52 20. 68 120 47% exposure 21. 56 21. 28 13. 80 168 47% exposure 19. 77 19. 22 12. 06 Example II-19 A sample was prepared in the same manner as in Example II-17 except that the drying temperature was 130 °C. The color of the sample is uneven because the color of the sample is a pale color with an irregular gray/black area (the appearance of a slightly motley appearance). The results from the color monitoring experiments are shown in Tables II-19. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1176 g exposed to light at about 20% relative humidity for 168 hr was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released in 35 minutes per gram of sample. 25 mg silver ion. In comparison, 0. The 1313 g sample stored in the foil released 24_93 mg of silver ions per gram of sample during 168 hours to 98 grams of distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 28,000 mg Ag/kg sample. The silver metal content is 1 500 mg/kg sample. Table II-19 Example II-19 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 51. 51 51. 71 35. 49 2 12% in foil 50. 74 51. 04 35. 16 4 11% in foil 52. 00 52. 29 35. 94 8 12% in foil 51. 99 52. 35 36. 25 24 11% in foil 51. 20 51. 50 35. 58 48 10% in foil 52. 60 53. 00 36. 81 120 16% in foil 50. 97 51. 30 35. 56 125842. Doc -71 - 200826950 168 18% in foil 52. 41 52. 82 36. 30 0 12% exposure 50. 84 50. 82 35. 60 2 12% exposure 51. 31 51. 21 35. 54 4 11% exposure 50. 89 50. 89 35. 24 8 12% exposure 51. 18 51. 01 35. 12 24 11% exposure 48. 48 48. 39 34. 79 48 10% exposure 47. 16 46. 46 31. 66 120 16% exposure 39. 85 39. 05 27. 42 168 18% exposure 35. 81 35. 16 23. 92 0 49% exposure 49. 81 49. 68 33. 88 2 49% exposure 49. 12 48. 88 31. 87 4 49% exposure 48. 67 48. 29 31. 3 8 48% exposure 46. 65 46. 07 29. 81 24 47% exposure 37. 12 36. 61 24. 49 48 47% exposure 29. 08 28. 96 19. 63 120 47% exposure 21. 56 21. 28 13. 80 168 47% exposure 19. 77 19. 22 12. 06 Example II-20 A sample was prepared in the same manner as in Example II-19 except that the drying temperature was 155 °C. Because the side is darker golden than the other side, the sample color is uneven. Test the lighter colors and display their results in Tables 11-20. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1358 g exposed to light at 168 hr at about 20% relative humidity was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 32 mg silver ion. In comparison, 0. 1395 g of sample stored in foil was released per gram of sample during 168 hours. 21 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 27,500 mg Ag/kg sample. The silver metal content is 125842. Doc -72- 200826950 3 1 00 mg/kg sample. Table 11-20 Example 11-20 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 37. 03 36. 21 17. 70 2 12% in foil 37. 95 37. 09 17. 57 4 11% in foil 37. 08 36. 22 17. 62 8 12% in foil 37. 19 36. 31 17. 84 24 11% in foil 37. 41 36. 57 17. 89 48 10% in foil 37. 49 36. 66 17. 89 120 16% in foil 37. 77 36. 96 18. 29 168 18% in foil 37. 96 37. 19 18. 36 0 12% exposure 36. 99 35. 89 17. 15 2 12% exposure 37. 00 35. 89 17. 66 4 11% exposure 37. 10 36. 02 17. 63 8 12% exposure 37. 45 36. 22 16. 96 24 11% exposure 36. 27 35. 08 17. 48 48 10% exposure 36. 04 34. 73 16. 60 120 16% exposure 34. 11 32. 62 15. 21 168 18% exposure 32. 21 30. 61 14. 38 0 49% exposure 38. 82 38. 1 19. 16 2 49% exposure 39. 06 38. 42 18. 93 4 49% exposure 38. 71 38. 04 18. 97 8 48% exposure 37. 95 37. 13 18. 08 24 47% exposure 36. 74 35. 63 16. 78 48 47% exposure 32. 61 31. 27 14. 58 120 47% exposure 23. 56 21. 15 9. 79 168 47% exposure 19. 31 16. 92 8. 47 Example 11-21 A sample was prepared in the same manner as in Example ΙΙ-1 except that the drying temperature was 180 °C. The sample color is golden yellow. Will be the result of the color monitoring experiment 125842. Doc •73 200826950 is shown in Table 11-21. Silver ion release and total silver content measurements were performed as described in Example ΙΙ-1. 0. A sample of 1405 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 10 mg silver ion. In comparison, 0. 1371 g of sample stored in foil released 0 per gram of sample during 168 hours. 52 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 1 850 mg Ag/kg sample. The silver metal content was 450 mg/kg sample. Table 11-21 Example 11-21 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 50. 36 50. 05 20. 82 2 12% in foil 51. 67 51. 46 21. 91 4 11% in foil 49. 33 48. 86 20. 45 8 12% in foil 49. 29 48. 79 20. 46 24 11% in foil 49. 98 49. 52 20. 58 48 10% in foil 50. 08 49. 59 20. 57 120 16% in foil 49. 38 48. 71 20. 35 168 18% in foil 49. 74 49. 16 20. 33 0 12% exposure 52. 53 52. 7 24. 77 2 12% exposure 52. 67 52. 83 24. 91 4 11% exposure 52. 89 53. 06 25. 05 8 12% exposure 52. 51 52. 66 24. 93 24 11% exposure 52. 61 52. 73 25. 15 48 10% exposure 52. 36 52. 42 25. 14 120 16% exposure 51. 86 51. 9 25. 09 168 18% exposure 50. 87 50. 94 24. 79 0 49% exposure 48. 59 48. 20 20. 93 125842. Doc -74- 200826950 2 49% exposure 47. 66 46. 93 19. 51 4 49% exposure 47. 71 47. 03 19. 80 8 48% exposure 46. 40 45. 63 18. 90 24 47% exposure 46. 19 45. 48 19. 32 48 47% exposure 43. 95 43. 16 18. 58 120 47% exposure 41. 76 41. 21 18. 86 168 47% exposure 40. 21 29. 71 18. 06 Example II-22 A sample was prepared in the same manner as in Example ΙΙ16 except that the drying temperature was 180 °C. The sample color is dark golden yellow. The results from the color monitoring experiments are shown in Table -22. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1364 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 80 mg silver ion. In comparison, 0. 1340 g of sample stored in foil was released per gram of sample during 168 hours. 88 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 16000 mg Ag/kg sample. Silver metal content is 2700 mg/kg sample ° Table 11-22 Example 11-22 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 24. 67 23. 32 10. 12 2 12% in foil 24. 74 23. 36 10. 25 4 11% in foil 24. 53 23. 01 8. 67 8 12% in foil 24. 89 23. 48 10. 08 24 11% in pigs 25. 33 23. 94 10. 77 48 10% in foil 25. 27 23. 77 10. 58 125842. Doc -75- 200826950 120 16% in foil 25. 43 23. 92 10. 47 168 18% in foil 25. 01 23. 45 10. 15 0 12% exposure 21. 93 20. 16 8. 52 2 12% exposure 21. 38 20. 13 8. 75 4 11% exposure 20. 28 18. 97 8. 62 8 12% exposure 19. 67 18. 37 8. 31 24 11% exposure 19. 97 18. 6 8. 09 48 10% exposure 19. 89 18. 52 8. 11 120 16% exposure 18. 76 17. 38 7. 46 168 18% exposure 19. 21 17. 93 8. 42 0 49% exposure 25. 39 24. 21 8. 56 2 49% exposure 27. 09 25. 73 8. 55 4 49% exposure 26. 13 24. 77 8. 20 8 48% exposure 25. 32 23. 98 8. 15 24 47% exposure 25. 71 24. 47 8. 26 48 47% exposure 23. 98 22. 67 8. 03 120 47% exposure 26. 62 25. 52 8. 75 168 47% exposure 26. 23 25. 16 8. 86 Example II-23 A sample was prepared in the same manner as in Example II-17 except that the drying temperature was 180 °C. The color of the sample is a dark color with a black color, which gives the appearance of a charred color. The results from the color monitoring experiments are shown in Table 11-23. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1443 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 50 mg silver ion. In comparison, 0. 1496 g of sample stored in foil was released per gram of sample during 168 hours. 30 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. 125842. Doc -76- 200826950 The average total silver content is 27500 mg Ag/kg sample. The silver metal content was 7500 mg/kg sample. Table 11-23 Example 11-23 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 15. 23 14. 06 8. 20 2 12% in foil 14. 81 13. 56 7. 38 4 11% in foil 15. 30 14. 00 7. 72 8 12% in foil 15. 28 13. 97 7. 64 24 11% in pigs 15. 48 14. 19 8. 01 48 10% in foil 15. 42 14. 16 8. 22 120 16% in pigs 15. 24 13. 88 7. 51 168 18% in foil 15. 61 14. 30 8. 13 0 12% exposure 14. 32 13. 09 6. 35 2 12% exposure 15. 14 13. 96 7. 40 4 11% exposure 15. 02 13. 89 8. 06 8 12% exposure 15. 05 13. 82 7. 27 24 11% exposure 15. 25 14. 03 7. 40 48 10% exposure 14. 37 13. 29 8. 21 120 16% exposure 15. 14 13. 90 7. 02 168 18% exposure 14. 63 13. 54 7. 64 0 49% exposure 15. 16 13. 88 7. 12 2 49% exposure 14. 98 13. 57 6. 67 4 49% exposure 15. 07 13. 63 6. 48 8 48% exposure 15. 90 14. 46 7. 15 24 47% exposure 15. 75 14. 41 7. 29 48 47% exposure 14. 94 13. 64 6. 67 120 47% exposure 15. 12 13. 86 7. 18 168 47% exposure 14. 30 13. 03 6. 45 Example 11-24 In the same manner as in Example II-10 except that the drying temperature was 130 ° C. Doc •77- 200826950 Prepare samples. The sample color is light yellow. The results from the color monitoring experiments are shown in Tables II-24. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1385 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate in the 30 minutes of release of 0 grams per gram of sample. 84 mg silver ion. In comparison, 0. 1286 g of sample stored in foil was released per gram of sample during 168 hours. 93 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 3750 Ag/kg sample. Table 11-24 Example 11-24 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 49. 48 48. 61 29. 17 2 12% in foil 49. 51 48. 61 29. 56 4 11% in foil 49. 87 48. 99 29. 80 8 12% in foil 49. 47 48. 55 29. 76 24 11% in foil 49. 55 48. 55 29. 99 48 10% in foil 49. 65 48. 72 29. 84 120 16% in foil 49. 56 48. 57 30. 69 168 18% in foil 49. 92 49. 02 30. 48 0 12% exposure 53. 26 52. 83 34. 06 2 12% exposure 53. 38 52. 95 34. 29 4 11% exposure 52. 99 52. 62 33. 81 8 12% exposure 52. 60 52. 34 33. 43 24 11% exposure 51. 75 51. 51 32. 31 48 10% exposure 51. 74 51. 48 32. 42 120 16% exposure 50. 66 50. 08 29. 90 168 18% exposure 48. 19 47. 37 26. 87 0 49% exposure 50. 77 50. 14 31. 19 125842. Doc -78 - 200826950 2 49% exposure 49. 79 48. 88 29. 28 4 49% exposure 49. 91 48. 91 29. 29 8 48% exposure 49. 92 48. 88 28. 65 24 47% exposure 46. 59 45. 05 26. 48 48 47% exposure 43. 36 42. 00 24. 19 120 47% exposure 35. 83 34. 86 20. 96 168 47% exposure 35. 53 34. 47 20. 33 Example II-25 A sample was prepared in the same manner as in Example 11-11 except that the drying temperature was 130 °C. The sample color is yellow brown. The results from the color monitoring experiments are shown in Table-25. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1377 g was exposed to light at about 20% relative humidity for 168 hr. The sample was placed in 98 g of distilled water with 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 14 mg silver ion. In comparison, 0. 1540 g of sample stored in foil was released per gram of sample during 168 hours. 01 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 6850 Ag/kg sample. Table 11-25 Example 11-25 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 40. 28 38. 41 20. 89 2 12% in foil 40. 30 38. 40 20. 89 4 11% in foil 40. 49 38. 61 21. 11 8 12% in foil 40. 58 38. 68 21. 09 24 11% in foil 40. 40 38. 53 21. 16 48 10% in foil 40. 70 38. 81 21. 25 120 16% in foil 40. 77 38. 93 21. 35 125842. Doc -79- 200826950 168 18% in foil 40. 95 39. 12 21. 51 0 12% exposure 37. 92 35. 71 19. 87 2 12% exposure 37. 55 35. 41 19. 68 4 11% exposure 37. 83 35. 7 20. 14 8 12% exposure 37. 38 35. 33 20. 07 24 11% exposure 36. 37 34. 48 19. 59 48 10% exposure 35. 85 33. 92 19. 08 120 16% exposure 34. 22 32. 05 18. 15 168 18% exposure 32. 83 30. 7 16. 99 0 49% exposure 41. 09 39. 20 21. 26 2 49% exposure 40. 12 37. 98 19. 59 4 49% exposure 39. 82 37. 54 19. 26 8 48% exposure 39. 04 36. 71 18. 93 24 47% exposure 37. 79 35. 21 17. 71 48 47% exposure 34. 82 32. 16 16. 40 120 47% exposure 26. 52 24. 84 13. 52 168 47% exposure 28. 89 23. 58 13. 31 Example II-26 except that the substrate is 100% TENCEL fiber nonwoven (SX-152, white, 65 gsm, 24 mesh) containing less than 40 ppm chloride from Green Bay Nonwovens, Inc., WI, Green Bay. In addition, samples were prepared in the same manner as in Example II-8. The sample color is golden yellow. The results from the color monitoring experiments are shown in Table -26. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1902 g exposed to light at 168 hr at about 20% relative humidity was placed in 98 g of distilled water and 2. 96 grams of 5M sodium nitrate was released per gram of sample within 30 minutes. 19 mg silver ion. In comparison, 0. The 1931 g sample stored in foil was released per gram of sample during 168 hours. 87 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. 125842. Doc -80- 200826950 The average total silver content is 7350 Ag/kg sample. Table 11-26 Example 11-26 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 25. 87 23. 52 6. 56 2 12% in foil 26. 24 23. 87 6. 69 4 11% in foil 26. 43 24. 05 6. 76 8 12% in foil 26. 11 23. 77 6. 70 24 11% in foil 26. 08 23. 74 6. 77 48 10% in foil 26. 45 24. 06 6. 71 120 16% in foil 26. 61 24. 20 6. 70 168 18% in foil 26. 97 24. 50 6. 69 0 12% exposure 26. 29 23. 91 7. 06 2 12% exposure 25. 01 22. 67 6. 35 4 11% exposure 25. 43 23. 19 6. 76 8 12% exposure 25. 79 23. 57 7. 01 24 11% exposure 24. 65 22. 66 6. 75 48 10% exposure 24. 02 22. 24 6. 90 120 16% exposure 21. 62 20. 28 6. 62 168 18% exposure 21. 35 20. 19 6. 89 0 49% exposure 26. 03 23. 70 6. 96 2 49% exposure 25. 31 23. 24 6. 65 4 49% exposure 24. 56 22. 73 6. 79 8 48% exposure 23. 39 21. 83 6. 82 24 47% exposure 21. 17 20. 31 7. 38 48 47% exposure 19. 46 19. 15 7. 82 120 47% exposure 18. 81 18. 93 9. 41 168 47% exposure 19. 06 19. 30 10. 53 Example 11-27 except that the substrate is 70% lysate/30% PET non-woven fabric containing less than 40 ppm chloride (SX-156, white, 50 gsm, FT-10 open, from 125842. Doc -81 - 200826950 Ahlstrom Green Bay, Inc., Green Bay, WI In addition, samples were prepared in the same manner as in Example II-8. The sample color is golden yellow. The results from the color monitoring experiments are shown in Table -27. Silver ion release and total silver content measurements were performed as described in Example II-1. 0. A sample of 1608 g of light exposed to light at about 20% relative humidity for 168 hours (hr) was placed in 98 grams of distilled water and 2. Release of 2.3 grams per gram of sample in 96 grams of 5M sodium nitrate within 30 minutes. 99 mg silver ion. In comparison, 0. 1515 g of sample stored in foil was released per gram of sample during 168 hours. 53 mg silver ion to 98 g distilled water and 2. 96 grams of sodium nitrate. The average total silver content was 8450 Ag/kg sample. Table 11-27 Examples 11-27 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 12% in foil 37. 89 36. 07 13. 51 2 12% in foil 38. 35 36. 52 13. 90 4 11% in the middle 38. 39 36. 59 13. 97 8 12% in foil 37. 93 36. 11 13. 38 24 11% in foil 38. 47 36. 66 13. 93 48 10% in foil 38. 01 36. 15 13. 20 120 16% in foil 38. 91 37. 08 14. 10 168 18% in foil 39. 18 37. 33 14. 01 0 12% exposure 39. 10 37. 42 14. 55 2 12% exposure 35. 30 34. 09 14. 17 4 11% exposure 34. 49 33. 64 14. 74 8 12% exposure 31. 97 31. 33 13. 88 24 11% exposure 29. 08 28. 92 13. 94 48 10% exposure 25. 77 25. 81 13. 32 120 16% exposure 22. 25 22. 60 12. 58 125842. Doc -82- 200826950 168 18% exposure 20. 82 21. 41 13. 62 0 49% exposure 39. 77 38. 03 15. 23 2 49% exposure 34. 17 33. 34 15. 14 4 49% exposure 29. 05 28. 56 13. 57 8 48% exposure 26. 53 26. 61 14. 47 24 47% exposure 22. 57 23. 18 15. 47 48 47% exposure 22. 06 22. 72 17. 23 120 47% exposure 20. 75 21. 17 17. 60 168 47% exposure 22. 96 23. 32 20. 73 Examples 11-28 (Comparative) Samples were prepared in the same manner as in Example II-4 except that the drying temperature was 80 °C. The initial color of the sample was off-white. The results from the color monitoring experiments are shown in Tables II-28. Table 11-28 Example 11-28 (Comparative) Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 90. 11 92. 05 103. 38 2 28% in foil 88. 36 90. 24 100. 54 4 28% in foil 89. 33 91. 28 101. 61 8 28% in foil 89. 45 91. 36 101. 37 24 28% in foil 87. 69 89. 60 98. 82 0 28% exposure 89. 91 91. 83 102. 77 2 28% exposure 81. 82 82. 87 91. 87 4 28% exposure 74. 05 74. 31 81. 64 8 28% exposure 64. 83 64. 22 67. 01 24 28% exposure 44. 04 43. 82 45. 43 0 50% exposure 91. 11 93. 06 105. 01 2 50% exposure 84. 35 85. 39 94. 23 4 50% exposure 76. 12 76. 24 81. 43 8 50% exposure 57. 88 56. 99 57. 51 24 50% exposure 36. 17 36. 59 35. 92 125842. Doc-83-200826950 Examples 11-29 (Comparative) Samples were prepared in the same manner as in Example Π-ll except that the drying temperature was 80 °C. The initial color of the sample was off-white. The results from the color monitoring experiments are shown in Table II-29. Table 11-29 Example 11-29 (Comparative) Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 88. 51 90. 40 98. 82 2 28% in foil 87. 96 89. 84 97. 60 4 28% in foil 88. 26 90. 13 97. 57 8 28% in the box 88. 29 90. 18 97. 03 24 28% in foil 86. 37 88. 27 93. 35 0 28% exposure 90. 06 91. 99 102. 55 2 28% exposure 86. 96 88. 49 97. 45 4 28% exposure 83. 47 84. 56 92. 26 8 28% exposure 75. 28 75. 27 79. 70 24 28% exposure 54. 60 54. 14 56. 55 0 50% exposure 88. 58 90. 47 99. 23 2 50% exposure 82. 85 83. 98 90. 29 4 50% exposure 75. 59 75. 77 81. 13 8 50% exposure 60. 09 59. 35 62. 85 24 50% exposure 34. 42 35. 74 37. 87 Example 11-30 (Comparative) In addition to the matrix of 70% human silk / 30% PET fiber non-woven fabric (507030RPET P1, white, 50 gsm, FA-MA JERSEY S. from Italy) p. A. In addition, samples were prepared in the same manner as in Examples 11-28. The initial color of the sample is off-white. The results from the color monitoring experiment are shown in Table -30 〇 125842. Doc -84- 200826950 Table II-3 0 Example 11-3 0 (comparative) color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 81. 37 82. 74 86. 19 2 28% in foil 80. 15 81. 31 84. 22 4 28% in foil 81. 30 82. 52 86. 23 8 28% in foil 80. 10 81. 18 84. 08 24 28% in foil 78. 68 79. 73 82. 21 0 28% exposure 84. 09 85. 69 90. 95 2 28% exposure 40. 47 41. 03 45. 52 4 28% exposure 34. 16 34. 53 38. 44 8 28% exposure 27. 04 27. 02 29. 61 24 28% exposure 22. 53 22. 32 23. 17 0 50% exposure 83. 47 84. 96 88. 89 2 50% exposure 36. 60 36. 75 40. 03 4 50% exposure 30. 65 30. 61 33. 06 8 50% exposure 24. 80 24. 51 24. 75 24 50% exposure 19. 87 19. 56 16. 79 Example 11-31 (Comparative) The matrix is 70% human silk / 30% PET fiber non-woven fabric (507030RPET P1, white, 50 gsm, FA-MA JERSEY S. from Italy). P. Samples were prepared in the same manner as in Examples 11-29 except for A·). The initial color of the sample is off-white. The results from the color monitoring experiment are shown in Table Π-3 1 〇 Table 11-31 Example 11-31 (Comparative) Color exposure time over time (hr) Relative humidity (%RH) Exposure condition CIE Tristimulus value XYZ 0 28% in the foil 83. 81 85. 50 89. 18 2 28% in foil 83. 26 84. 89 88. 50 125842. Doc • 85 - 200826950 4 28% in foil 83. 92 85. 59 89. 66 8 28% in foil 82. 67 84. 25 87. 58 24 28% in foil 81. 72 83. 42 86. 21 0 28% exposure 85. 94 87. 80 92. 68 2 28% exposure 50. 71 51. 40 58. 32 4 28% exposure 42. 69 43. 07 48. 42 8 28% exposure 32. 40 31. 80 33. 98 24 28% exposure 24. 65 24. 29 24. 94 0 50% exposure 84. 83 86. 65 90. 38 2 50% exposure 45. 73 46. 53 51. 53 4 50% exposure 37. 08 37. 04 39. 38 8 50% exposure 28. 42 27. 50 26. 63 24 50% exposure 19. 13 17. 95 14. 25 Example 11-32 (Comparative) A sample was prepared in the same manner as in Example II-27 except that the drying temperature was 80 °C. The initial color of the sample was off-white. The results from the color monitoring experiments are shown in Tables II-32. Table 11-32 Example 11-32 (Comparative) Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 82. 78 83. 66 90. 59 2 28% in foil 82. 40 83. 23 90. 07 4 28% in foil 82. 70 83. 49 90. 27 8 28% in foil 82. 50 83. 21 89. 90 24 28% in foil 80. 46 81. 05 87. 50 0 28% exposure 84. 02 85. 04 91. 42 2 28% exposure 41. 48 41. 60 46. 75 4 28% exposure 32. 67 32. 97 38. 11 8 28% exposure 28. 61 29. 01 33. 61 24 28% exposure 23. 99 24. 36 28. 34 0 50% exposure 84. 96 86. 10 93. 01 125842. Doc -86 - 200826950 2 50% exposure 40. 73 40. 84 46. 51 4 50% exposure 33. 88 34. 04 39. 12 8 50% exposure 29. 17 29. 43 33. 70 24 50% exposure 25. 38 25. 52 27. 80 Example II-33 A sample was prepared in the same manner as in Example -30 except that the drying temperature was 155 °C. The initial color of the sample is golden brown. The results from the color monitoring experiments are shown in Table-33. Table 11-33 Example 11-33 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 26. 03 24. 03 9. 53 2 28% in foil 25. 72 23. 77 9. 42 4 28% in foil 25. 69 23. 77 9. 46 8 28% in foil 25. 77 23. 87 9. 16 24 28% in foil 26. 48 24. 47 9. 62 0 28% exposure 27. 95 25. 92 8. 87 2 28% exposure 25. 83 24. 13 8. 88 4 28% exposure 24. 13 22. 58 8. 67 8 28% exposure 21. 78 20. 62 8. 59 24 28% exposure 18. 66 18. 03 8. 31 0 50% exposure 25. 77 23. 92 8. 58 2 50% exposure 24. 15 22. 54 8. 41 4 50% exposure 22. 97 21. 47 8. 38 8 50% exposure 20. 79 19. 59 8. 18 24 50% exposure 17. 63 16. 97 7. 64 Example 11-34 A sample was prepared in the same manner as in Example ΙΙ-31 except that the drying temperature was 155 °C. The initial color of the sample is golden brown. Will come from the color monitoring real 125842. Doc -87- 200826950 The results of the test are shown in Table 11-34. Table 11-34 Example 11-34 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 27. 80 26. 40 11. 98 2 28% in foil 28. 41 27. 00 12. 17 4 28% in foil 28. 37 26. 96 12. 06 8 28% in foil 28. 07 26. 65 11. 88 24 28% in foil 28. 05 26. 61 11. 91 0 28% exposure 29. 39 28. 01 13. 29 2 28% exposure 28. 68 27. 36 13. 17 4 28% exposure 28. 93 27. 67 13. 44 8 28% exposure 27. 55 26. 33 12. 96 24 28% exposure 26. 04 24. 83 12. 44 0 50% exposure 29. 57 28. 45 12. 61 2 50% exposure 27. 29 26. 42 12. 20 4 50% exposure 25. 72 24. 96 11. 72 8 50% exposure 24. 79 24. 21 12. 14 24 50% exposure 22. 14 22. 01 11. 44 Example 11-35 (Except that the substrate was woven nylon fiber (SR-823-32x28, 60 gsm, from NC, Albemarle, American Fiber and Finishing), samples were prepared in the same manner as in Example II-8. The initial color is brown. The results from the color monitoring experiment are shown in Table-35. Table 11-35 Example 11-35 Color exposure time over time (hr) Relative humidity (%RH) Exposure condition CIE tristimulus value XYZ 0 28% in the foil 48. 45 48. 01 40. 25 2 28% in foil 47. 78 47. 23 39. 54 125842. Doc -88- 200826950 4 28% in foil 49. 45 48. 98 41. 26 8 28% in foil 51. 37 51. 02 43. 06 24 28% in foil 49. 61 49. 19 41. 67 0 28% exposure 45. 29 44. 93 39. 33 2 28% exposure 46. 72 46. 56 42. 18 4 28% exposure 44. 99 44. 80 40. 59 8 28% exposure 44. 05 43. 65 38. 92 24 28% exposure 42. 50 42. 01 37. 52 0 50% exposure 46. 14 46. 01 39. 51 2 50% exposure 58. 75 59. 19 56. 32 4 50% exposure 56. 22 56. 55 53. 54 8 50% exposure 47. 25 47. 12 42. 27 24 50% exposure 50. 58 50. 64 47. 74 Example II-36 Samples were prepared in the same manner as in Example II-11 except that the substrate was a woven nylon fiber (SR-823-32x28, 60 gsm, from American, Fiber and Finishing by Albemarle). The initial color of the sample is brown. The results from the color monitoring experiments are shown in Tables 11-36. Table 11-36 Example 11-36 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 36. 27 35. 64 27. 31 2 28% in foil 44. 44 44. 49 37. 32 4 28% in foil 35. 03 34. 84 29. 53 8 28% in foil 36. 56 36. 33 30. 93 24 28% in foil 33. 35 33. 65 28. 49 0 28% exposure 35. 83 35. 60 28. 67 2 28% exposure 35. 22 34. 94 28. 33 4 28% exposure 33. 89 33. 51 27. 10 8 28% exposure 34. 26 33. 96 28. 05 24 28% exposure 33. 22 32. 93 27. 19 125842. Doc -89- 200826950 0 50% exposure 31. 39 31. 09 25. 81 2 50% exposure 32. 89 32. 53 27. 09 4 50% exposure 32. 20 31. 88 26. 69 8 50% exposure 32. 22 31. 92 27. 21 24 50% exposure 29. 86 29. 55 25. 23 Example II-37 In addition to the matrix is a membrane filter containing nitrocellulose and cellulose acetate (0. Samples were prepared in the same manner as in Example 11_8 except for a 22 μΜ filter, GSWP 047 00, available from Millipore of Billerica. The initial color of the sample is light brown. The results from the color monitoring experiments are shown in Table II-37. Table 11-3 7 Example 11-3 7 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in pigs 52. 70 53. 08 43. 49 2 28% in foil 50. 38 50. 72 41. 49 4 28% in foil 53. 88 54. 26 44. 62 8 28% in foil 50. 92 51. 35 41. 98 24 28% in foil 48. 23 48. 58 39. 78 0 28% exposure 47. 75 48. 06 41. 09 2 28% exposure 47. 95 48. 23 40. 67 4 28% exposure 46. 68 46. 97 39. 67 8 28% exposure 48. 14 48. 36 40. 63 24 28% exposure 47. 60 47. 90 40. 14 0 50% exposure 35. 99 35. 72 29. 34 2 50% exposure 37. 17 36. 71 30. 12 4 50% exposure 35. 95 35. 53 29. 08 8 50% exposure 40. 81 40. 07 32. 55 24 50% exposure 34. 63 34. 17 27. 51 Example 11-38 125842. Doc •90· 200826950 In addition to the matrix is a membrane filter containing nitrocellulose and cellulose acetate (0. Samples were prepared in the same manner as in Examples II-11 except for a 22 μΜ filter, GSWP 047 00, available from MA, Millipore of Billerica. The initial color of the sample is light brown. The results from the color monitoring experiments are shown in Tables 11-38. Table 11-3 8 Examples 11-38 Color over time Exposure time (hr) Relative humidity (%RH) Exposure conditions CIE tristimulus value X Y Z 0 28% in foil 48. 08 48. 44 46. 63 2 28% in foil 46. 75 47. 11 45. 86 4 28% in foil 44. 59 44. 96 45. 32 8 28% in foil 46. 32 46. 63 45. 72 24 28% in foil 44. 24 44. 58 44. 62 0 28% exposure 57. 66 57. 96 55. 63 2 28% exposure 55. 49 55. 78 53. 51 4 28% exposure 56. 39 56. 66 54. 42 8 28% exposure 52. 69 52. 98 51. 03 24 28% exposure 53. 82 54. 07 52. 28 0 50% exposure 53. 64 53. 91 50. 99 2 50% exposure 46. 59 46. 92 45. 26 4 50% exposure 51. 65 51. 91 49. 15 8 50% exposure 52. 03 52. 34 49. 42 24 50% exposure 50. 82 51. 14 48. The complete disclosure of the patents, patent documents, and publications cited herein is hereby incorporated by reference in its entirety in its entirety in its entirety in its entirety. Numerous modifications and variations of the present invention will be apparent to those skilled in the art without departing from the scope of the invention. It should be understood that the present invention is not intended to be unduly limited by the illustrative implementations set forth herein. Doc-91 - 200826950 Examples and examples, and such examples and embodiments are presented by way of example only, and the scope of the invention is intended to be limited only by the scope of the invention as set forth herein below.

125842.doc -92-

Claims (1)

200826950 X. Patent Application ‧ A method for manufacturing an antimicrobial article comprising: applying a silver composition to a substrate to provide a liquid coating substrate, the silver composition comprising non-sulfuric acid in a solvent Silver silver salt, the silver composition comprising a stabilizer in an amount of less than about 100 ppm; the matrix comprising a material selected from the group consisting of polyamine, polyester, polyacetate, polyacrylic acid, poly Olefins, polyurethanes, polyvinyl chloride, polyvinyl alcohol, polycarbonate, polyethylene 0-rrolidone, polylactic acid, ethylene vinyl acetate, polystyrene, cellulose acetate, polyacrylate, poly Acrylamide, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyoxymethylene, polyvinyl ether, styrene-ethylene butylene-styrene elastomer, styrene-butene_styrene elastomer, benzene Ethylene-isoprene-styrene elastomer, glass fiber, ceramic, and combinations of two or more of the foregoing; and drying the liquid coating substrate to provide a silver salt comprising the substrate Stable color Antimicrobial objects. The method of claim 1, wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver vapor, silver barnate, silver lactate, silver nitrate, and sulphate Silver, silver chlorite, sulphuric acid, sulphuric acid, S-dihydrogen silver, silver acetate, silver propionate, tartaric acid, weak protein silver, protein silver, and two or more of these substances combination. 3. The method of claim 2 wherein the silver salt is silver nitrate. 4. The method of claim 2, wherein the silver salt is silver benzoate. 125842.doc 200826950 5 · The method of claim 1 wherein the silver s® and the west A 丄r β silver salt are selected from the group consisting of silver iodate, silver oxalate, silver sulphate m ~ Amine pyrimidine silver, saccharin silver, silver o-aminobenzoate, nitric acid plate _ moon silver, meat ugly silver, silver palmitate, silver stearate and the above substances < w shell r two Kind or a combination of two or more. 6. The method of any one of the preceding claims, wherein the substrate comprises a polyolefin selected from the group consisting of polypropylene, polyethylene, ethylene propylene copolymer, ethylene butyl copolymer, and And a combination of two or more of the foregoing substances f. 7. The method of any one of claims 1 to 5, wherein the matrix comprises polyamine. 8. The method according to any one of claims 1 to 5, wherein the substrate comprises cellulose acetate. U. The method of any of items 1 to 8, wherein the substrate comprises a material selected from the group consisting of a porous substrate, a braid, a braid, a non-woven fabric, an extruded porous sheet, and a perforated sheet. . The method of any one of claims 1 to 9, wherein the silver composition comprises a stabilizer in an amount of less than 5 () ppm based on the total weight of the silver salt composition. The method of claim 10 wherein the silver composition does not contain a stabilizer. The method of any one of claims 1 to 7, wherein the liquid-coated substrate is dried at room temperature. 13. The method of any one of clauses 1 to i, wherein the liquid-coated substrate is dried at a temperature of less than about 100 °C. The method of any one of claims 1 to 13, wherein the color stable anti-125842.doc 200826950 microbial article comprises a silver salt coated on the substrate, wherein the silver concentration on the substrate is less than about 40, 〇〇〇mg Ag/kg matrix. The method of claim 14, wherein the color stable antimicrobial article comprises a silver salt coated on the substrate, wherein the silver concentration on the substrate is less than about 20, 〇〇〇 mg Ag/kg matrix. 16. The method of claim 15 wherein the color stable antimicrobial article comprises a silver salt coated on the substrate, wherein the silver concentration on the substrate is less than about 10,000 mg Ag/kg matrix. a V, 17· article comprising: a non-sulphate silver salt coated on a substrate; and the substrate comprising a material selected from the group consisting of polyamines, Polyester, Polyacetate, Polyacrylic Acid, Polyolefin, Polyurethane, Polyethylene, Polyvinyl Alcohol, Polycarbonate, Polyvinylpyrrolidone, Polylactic Acid, Ethylene Vinyl Acetate, Polystyrene , cellulose acetate, polyacrylate, polypropylene decylamine, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyfurfural, polyvinyl ether, styrene·ethylene butylene-styrene elastomer a styrene-butene-styrene elastomer, a styrene-isoprene-styrene elastomer, a glass fiber, a ceramic, and a combination of two or more of the foregoing; and wherein the article is resistant Microorganisms and colors are stable. Silver acid, continuous amine sputum sputum silver, sub-acid acid. , silver citrate, silver nitrite, silver oxalate, phosphorus, silver saccharinate, silver amide benzoate, yttrium 125842.doc 200826950 silver trihydrogen hard acid, silver silver citrate, silver acetyl phthalate, silver propionate , silver stearate, tartar silver and two or two of the foregoing, wherein the silver salt is selected from the group consisting of: 酴 button*, silver citrate, silver carbonate , silver chloride, citric acid Silver citrate, silver nitrate, silver nitrite, silver sulphate, silver fluorite, silver sulphate - & • silver, silver propionate, silver propionate, silver tartrate, weak protein silver, protein Silver and a combination of two or more of the foregoing. 2. The article of claim 19, wherein the silver salt is silver nitrate. 21. The article of claim 19, wherein the silver salt is silver benzoate. 22. The article of claim 18, wherein the silver salt is selected from the group consisting of silver iodate, silver oxalate, silver phosphate, silver sulfadiazine, silver saccharinate, silver o-aminobenzoate, silver nitrite , silver myristate, brown acid Silver, silver fluoroantimonate, secondary silver, silver myristate, silver acid, weak protein silver, combinations of the above. Silver, silver stearate, and a combination of two or more of the foregoing. The article of any one of claims 17 to 22, wherein the substrate comprises polyamine. The article of any one of claims 17 to 22, wherein the substrate comprises cellulose acetate. The article of any one of claims 17 to 24, wherein the silver concentration on the substrate is less than about 40,000 mg Ag/kg matrix. 2 6. The article of claim 2, wherein the silver concentration on the substrate is less than about 125842.doc 200826950 wherein the silver concentration on the substrate is less than about 20.000 mg Ag/kg matrix 27. The object of claim 26: The article of any one of clauses 7 to 27, wherein the concentration of the tanning agent is less than about 丨〇〇〇ppm based on the total weight of the article. 29. The article of claim 28, wherein the concentration of the stabilizer is less than about 500 ppm based on the weight of the object. 30. The article of claim 29, wherein the concentration of the stabilizer is less than about 100 ppm with a total reset of the article. 3 1 - A method of making an antimicrobial article, comprising: applying a silver composition to a substrate to provide a liquid coating substrate comprising a silver salt selected from the group consisting of: Silver acetate, silver benzoate, silver carbonate, silver vapor, silver citrate, silver sulphate, silver lactic acid, silver nitrate, silver nitrite, silver oxalate, silver phosphate, silver sulfadiazine, silver saccharinate, silver ortho-benzoate , silver chlorite, silver fluoroantimonate, silver succinate, silver sulphate, silver acetyl phthalate, silver myristate, silver palmitate, silver propionate, silver stearate, silver tartar, weak a protein silver, a silver protein, and a combination of two or more of the foregoing; and heating the liquid coating substrate at a temperature sufficient to form a silver metal from the silver salt to provide a silver metal nanoparticle and a silver salt. Color stable antimicrobial items. 32. The method of claim 31, wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver chloride, citric acid 125842.doc 200826950 1'::acid silver , silver nitrate, silver nitrite, silver chlorite, silver chlorofluoric acid, silver silver silver, weak protein #, 1 A &, and two or two of the foregoing A combination of the above. 33. The method of item 32, wherein the silver salt is silver acetate. 34. The method of claim 32, wherein the silver salt is silver benzoate. The method of the member 3' wherein the silver salt is selected from the group consisting of:, bismuth silver, #gman silver, silver phosphate, silver sulfadiazine, saccharin amide silver benzoate, silver hexamerate, And a combination of two or more of the foregoing, the method of any one of the preceding items, wherein the substrate comprises Free of the following materials: a cellulosic material, nylon, polyamide, polyacetate, collagen, gelatin, polyacrylamide, natural rubber, alginate, and two or two of these A combination of the above. The method of claim 36, wherein the substrate further comprises a material selected from the group consisting of: polyacetic acid, polyacrylic acid, polyhydrocarbon, polyurethane vinegar, and ethylene oxide including polyethylene Base, polystyrene, glass fiber, ceramic fiber, polyacrylic acid vinegar, polypropylene guess, polyethylene glycol, polytetraethylene, tannic acid, polyvinyl alcohol, polylactic acid, polyethylene Bismuth, polyethylene biting ketone, polycarbonate, styrene _ _ butyl succinyl _ stupid ethylene elastomer, styrene - butadiene styrene elastomer, styrene · isoprene - styrene An elastomer and a combination of two or more of the foregoing materials, 125842.doc 200826950. 38. The method of claim 36 or 37, wherein the matrix comprises a cellulosic material. The method of claim 38, wherein the cellulosic material is an absorbent carboxymethylated material selected from the group consisting of carboxymethylated cotton, hydrazine methylated cellulose, and a methylated solvent. A spun cellulose fiber and a slow methylated hydrazine and a combination of two or more of the foregoing. The method of claim 38, wherein the cellulosic material is selected from the group consisting of cotton, alfalfa, hemp, jute, bamboo fiber, cellulose acetate, and hydrazine methylated solvent-spun cellulose. And a combination of two or more of the foregoing: The method of any one of claims 31 to 40, wherein the substrate comprises a material selected from the group consisting of porous substrates comprising: The method of any one of claims 31 to 41, wherein the heating is effected at a temperature in the range of about 95 = to about 225 C. The liquid-coated substrate. The method of claim 42, wherein the heating the liquid-coated substrate is carried out at a temperature in the range of from about 1 Torr to about 2 Torr. 44. The method of claim 43, Wherein the liquid coating substrate is heated at a temperature in the range of from about 11 Torr to about 180 ° C. 45. The method of claim 44, wherein the method is in the range of from about 13 Torr to about 175 ° C. Heating the liquid coating substrate at a temperature of 46. The method of any one of claims 31 to 45, wherein the silver salt solution comprises a stabilizer in an amount of less than 1 〇〇ppm based on the total weight of the silver composition. 47. The method of claim 46, wherein The silver salt solution does not contain a stabilizer. The method of any one of claims 31 to 47, wherein the antimicrobial article is color stable and has a non-white color. A method of articles comprising: applying a silver composition to a substrate to provide a liquid coating substrate comprising a silver salt other than silver sulfate; and heating at a temperature sufficient to form silver metal from the silver salt The liquid is coated with a base to provide a color-stable antimicrobial article comprising silver metal nanoparticles and a silver salt. 50. The method of claim 49, wherein the silver salt is selected from the group consisting of: Silver, silver benzoate, silver carbonate, silver chloride, silver citrate, silver lactic acid, silver nitrate, silver nitrite, silver chlorite, silver fluoroantimonate, silver trihydrogen thiourate, silver acetyl laurate Silver propionate, tartaric acid And a combination of two or more of the foregoing, the method of claim 50, wherein the silver salt is silver nitrate. The silver salt is a silver benzoate. The method of claim 49, wherein the silver salt is selected from the group consisting of silver iodate, silver oxalate, silver phosphate, silver sulfadiazine, silver saccharinate, ortho-amino group. And a combination of two or more of the foregoing, the method of any one of claims 49 to 53, wherein the method of any one of claims 49 to 53 Wherein the matrix comprises a material selected from the group consisting of: cellulose materials, nylon, polyamide, polyacetate, collagen, gelatin, polypropylene decylamine, natural rubber 125842.doc 200826950 耀 L, Wear " bath salts and combinations of two or more of these aforementioned substances. The method of claim 54, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefin, polyurethane, aliquot, 1 styrene, Polystyrene, glass fiber, ceramic fiber, polyacrylate, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyfluorene, vinyl alcohol, polylactic acid, polyvinyl ether, polyethylene Pyridinium f, ketone, polycarbonate, styrene_ethylene butylene_styrene elastomer, styrene-butene_stupyl ethylene elastomer, styrene-isoprene_stupyl ethylene elastomer, and the like Two or more combinations. The method of claim 54 or 55, wherein the matrix comprises a cellulosic material. The method of claim 5, wherein the cellulosic material comprises an absorbent carboxymethylated material selected from the group consisting of carboxymethylated cotton, carboxymethylated cellulose, carboxymethylated solvent spinning Cellulose fiber and carboxymethylated hydrazine and a combination of two or more of these. The method of claim 56, wherein the cellulosic material is selected from the group consisting of:, cotton, eucalyptus, hemp, jute, bamboo fiber, cellulose acetate, 竣methyl A solvent-spun cellulosic fiber and a combination of two or more of the foregoing. The method of any one of claims 49 to 58, wherein the substrate comprises a material selected from the group consisting of porous substrates comprising: knitted fabrics, woven fabrics, non-woven fabrics, extruded porous sheets And perforated sheets. The method of any one of claims 49 to 59, wherein heating the liquid coating substrate is carried out at a temperature ranging from about 225 °C. 125842.doc 200826950 61. The method of claim 60, wherein the method is about 1 〇〇. Heating the liquid coating substrate is achieved at a temperature in the range of about 2 °C. 62. The method of claim 61, wherein the heating the liquid coating substrate is effected at a temperature in the range of from about n (rc to about i8 (rc). 63. The method of claim 62, wherein the system is about 13 〇 The liquid coated substrate is heated to a temperature within about 175 art. The method of any one of clauses 49 to 63, wherein the silver salt solution comprises a stabilizing agent in an amount less than the total weight of the silver sulphate composition. 65. The method of claim 64, wherein the silver salt solution does not comprise a stabilizer. The method of any one of claims 49 to 65, wherein the antimicrobial article is color stable and has a non-white color. 67. An object comprising: a silver metal and a silver salt on a woman's base, the silver salt being selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver sulfate, lemon Acid silver, (iv) silver, silver lactate, silver, silver nitrite, silver oxalate, silver phosphate, silver sulfonamide, silver saccharin, silver phthalate, silver sulphate, silver sulphur, sulphur Acid trihydrogen silver, hyponitric acid = silver acetyl laurate, silver oleic acid, silver palmitate, silver propionate, silver sulphate, silver tartar, weak protein silver, protein silver, and two of the foregoing Or a combination of two or more. 68. The article of claim 67, wherein the silver salt is selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver vapor, silver silver, silver lactate, silver nitrate, and stony Silver succinate, silver sulphate, sulphuric acid, sulphuric acid, silver dihydrogenate, silver propionate, silver propionate, tartaric acid 125842.doc 200826950 silver, weak protein silver, silver and these Two or more combinations of substances. 69. The article of claim 68, wherein the silver salt is silver nitrate. 7. The object of claim 68, wherein the silver salt is silver benzoate. The article of claim 67, wherein the silver salt is selected from the group consisting of silver sulphate, silver acid, silver phosphate, scutellite silver, saccharin silver, silver ortho-aminobenzoate, A silver nitrate, silver myristate, silver palmitate, silver stearate, and a combination of two or more of the foregoing, wherein the substrate comprises any one of the items of any one of claims 67 to 71, wherein the substrate comprises a material selected from the group consisting of 2 materials of the following groups: cellulose materials, nylon, polyamide, polyacetate, collagen, gelatin, polyacrylamide, natural rubber, brown «salt and Yan Hai, etc. Kind or a combination of two or more. 73. The article of claim 72, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefin, polyamine-based polystyrene, polystyrene B Dilute, glass fiber, ceramic fiber, polyacrylate, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, polyformic acid, polyvinyl alcohol, polylactic acid, polyethylene _, polyethylene mouth bilge, Polycarbonate, styrene-ethylene butadiene-styrene elastomer, stupid ethylene butylene-styrene elastomer, styrene-isoprene-styrene elastomer and two or two of the foregoing A combination of the above. 74. The article of claim 72 or 73, wherein the base f comprises a cellulosic material. 75. The article of claim 74, wherein the cellulosic material comprises an absorbent carboxymethylated material selected from the group consisting of 125842.doc • 11 - 200826950: carboxymethylated cotton, 鲮methylated fiber a carboxymethylated solvent-spun cellulose fiber and a carboxymethylated hydrazine and a combination of two or more of the foregoing. Soil 7 6 · The object of the item 7 4, wherein the group consists of cotton, glutinous rice, vegan, carboxymethylated solvent spun fiber or a combination of two or more. The 6-cell cellulose material is selected from the following: hemp, jute, bamboo fiber, cellulose acetate fiber and two of the foregoing 77. The article of any one of clauses 67 to 76, wherein the substrate is a material selected from the group consisting of a porous substrate, a braid, a braid, a non-woven fabric, an extruded porous sheet, and a perforated sheet. . 78. The article of claim 67 to 77, wherein the antimicrobial article is color stable and has a non-white color. The article of any one of claims 67 to 78, wherein the silver concentration on the substrate is less than about 40, 〇〇〇 mg Ag/kg matrix. 8. The article of claim 79 wherein the concentration of silver on the substrate is less than about 20,000 mg Ag/kg matrix. 81. The article of claim 8G, wherein the concentration of silver on the base f is less than about 10,000 mg Ag/kg matrix. 82. An article comprising: a silver metal and a silver salt coated on a substrate comprising a silver salt of non-sulph sulfate. 83. The article of claim 82, wherein the silver salt is selected from the group consisting of silver, silver formate, silver carbonate, silver sulfate, silver citrate, silver citrate, silver nitrate, Silver nitrite, silver sulphate, tartaric acid 125842.doc -12 - 200826950 哿中过峨k dihydrogen silver, silver acetate, silver propionate, tartaric acid. Silver, weak protein silver, protein silver and Two or more of these aforementioned substances are combined. 84. The article of claim 83, wherein the silver salt is silver nitrate. 85. The object of claim 83, wherein the silver salt is silver benzoate. 86. The article of claim 82, wherein the silver salt is selected from the group consisting of silver iodate, silver oxalate, silver phosphate, silver sulfadiazine, saccharin (silver, silver phthalate, secondary) A silver nitrate, silver myristate, silver palmitate, and a combination of two or more of the foregoing. The object of any one of claims 82 to 86, wherein the substrate comprises The materials selected from the group consisting of cellulose materials, nylon, polyamide, polyacetic acid, collagen, gelatin, polyacrylamide, natural rubber alginate, and two of the foregoing The combination of two or more of the items of claim 87, wherein the substrate further comprises a material selected from the group consisting of polyester, polyacrylic acid, polyolefin 'polyamine-based, acid vinegar, Polyvinyl chloride, polystyrene, glass fiber, ceramic fiber, polyacrylic acid vinegar, polyacrylonitrile, polyvinylidene fluoride, polytetrafluoroethylene, poly(1) formic acid, polyvinyl alcohol, polylactic acid, polyvinyl ether, polyethylene Pyrrolizidine, polycarbonate, phenyl b - an ethylene-butene-styrene elastomer, a styrene-butylene-styrene elastomer, a styrene-isoprene-styrene elastomer, and a combination of two or more of the foregoing. The article of claim 87 or 88, wherein the substrate comprises a cellulosic material. The article of claim 89, wherein the cellulosic material comprises a group selected from the group consisting of: The absorbent slow-methylating material: 竣methylated cotton, rebel cellulose, slow-methylated solvent-spun cellulose fiber, 竣methylated snail, and a combination of two or more of the foregoing. 9. The article of claim 89, wherein the cellulosic material is selected from the group consisting of cotton, alfalfa, hemp, jute, bamboo fiber, cellulose acetate, and a methylated solvent. And a material of any one of the above-mentioned materials, wherein the substrate is a material selected from the group consisting of the following: : Porous substrates, braids, braids, extruded porous sheets and wear A sheet of pores, wherein the antimicrobial article is silver on the substrate. 93. The article of any one of claims 82 to 92 is color stable and has a non-white color. The article of any one of the preceding claims, wherein the concentration is less than about 40, 〇〇〇mg Ag/kg of the substrate. 95. The article of claim 94, wherein the concentration of silver on the substrate is less than about 20.000 mg Ag/kg matrix 96. The article of claim 95, wherein the concentration of silver on the substrate is less than about 10.000 mg Ag/kg matrix. 125842.doc -14- 200826950 VII. Designation of representative drawings: (1) The representative representative of the case is: (None) (2) A brief description of the symbol of the representative figure: 8. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: (none) 125842.doc