TW200817040A - Emulsion composition with good feeling of use - Google Patents

Abstract

Disclosed is an emulsion composition containing an algae colloid and a hyaluronic acid, which gives smooth feeling of use. Specifically disclosed is an emulsion composition obtained by blending an acetylated hyaluronic acid into an emulsion composition containing an algae colloid and a hyaluronic acid. This emulsion composition gives smooth feeling of use when used as an external preparation for skin.

Description

[Technical Field] The present invention relates to an emulsified composition containing a brown algae extracting gel and hyaluronic acid and having a smooth feeling of use, and is particularly suitable for an emulsified composition of a skin external preparation. [Prior Art] It is known that both brown algae extract gel and hyaluronic acid are components having excellent moisturizing action and promoting blood flow, and are widely used in cosmetics and the like. The brown algae extract is a natural component extracted from brown algae, which is a polysaccharide formed by a point-D-mannuronic acid and a-L-groic acid with a /3 -1,4-bond, and is alginate. Main ingredient. It is known that the brown algae extracting gel has an excellent moisturizing effect as well as a skin-beautifying effect. As for hyaluronic acid, it is a substance having a repeating disaccharide structure formed by D-glucosinated acid and D-N-acetylglucosamine as a no-glycosidic bond, and is a polymer compound having a molecular weight of several millions. And because hyaluronic acid has a relatively long acid sugar chain, it has a high water content. The cosmetic containing both the brown algae extract gel and hyaluronic acid may, for example, be a plant extract containing (A) Lythraceae Lagerstroemia L., and one or more selected from (B) brown algae extract ( A skin-based cosmetic characterized by a group of physiologically active ingredients such as a whitening agent, an antioxidant, an anti-inflammatory agent, an ultraviolet ray preventive agent, a hyaluronic agent such as hyaluronic acid, a cell stimulating agent, and a blood flow promoting agent (patent document) 1). However, the emulsified composition containing brown algae extract gel and hyaluronic acid has a drawback of lack of smoothness and poor feeling in use. -5-200817040 Patent Document 1 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。

It is known that hyaluronic acid after acetylation has better moisturizing properties than hyaluronic acid. In addition, since the hydrophobicity is increased by the introduction of the acetyl group, the affinity for the keratin is high, the stringiness is lowered, and the solubility to alcohol is good, and the like is suitable for use as a collateral component of the external preparation for skin. . [Explanation] 6 - 200817040 The present invention provides a technique for providing an emulsified composition such as a cosmetic material containing brown algae extract gel and hyaluronic acid, and imparting a smooth feeling of use. In order to solve the above problems, the inventors of the present invention have found that the emulsified composition containing brown algae extract gel and hyaluronic acid can be improved in the degree of smoothness during use by using acetaminophen hyaluronic acid. The invention described below. (1) An emulsified composition comprising brown algae extract gel, hyaluronic acid, and acetylated hyaluronic acid. (2) The emulsified composition of (1), wherein the emulsified composition is an oily emulsified composition in water. (3) The emulsified composition according to (1) or (2), which is an external preparation for skin. In the emulsified composition containing brown algae extract and hyaluronic acid, the hyaluronic acid can be improved by blending with acetylated hyaluronic acid, thereby reducing the friction when applied to the skin. In the present specification, "slipness" is used to indicate the degree of feeling of friction of the skin of the finger or the applied portion of the coating when the emulsified composition is applied to the skin. The degree of smoothness is generally evaluated in addition to the subject's functional evaluation, and can also be evaluated using rheological properties such as viscosity. The present invention is emulsified. The composition contains brown algae extract gel, hyaluronic acid and acetylated hyaluronic acid. In the present invention, the brown algae extraction gel is a natural component extracted from brown algae and is mainly composed of alginic acid. Alginic acid is a polysaccharide formed by /3 -D-mannuronic acid and a-L-groic acid with a /5-1,4-bond. The brown algae extract can be extracted from brown algae. Commercially available products can also be used, and such commercially available products include, for example, brown algae extract rubber (manufactured by BOTTGER Co., Ltd.). 200817040 The content of the brown algae extracting gel is not particularly limited, and is preferably 0.001 to 5% by weight based on the total amount of the emulsified composition, more preferably 0.005 to 2% by weight, most preferably 0. 01 to 1% by weight. In the present invention, hyaluronic acid has a repeating disaccharide structure formed by D-glucuronic acid and DN-acetylglucosamine as a /3-glycosidic bond, and is a polymer compound having a molecular weight of up to several million. And its salt. The hyaluronic acid used in the present invention is not particularly limited in its molecular weight, but is preferably from 10,000 to 50,000, and is preferably from 100,000 to 2,000,000. Examples of the salts of hyaluronic acid include metal salts such as sodium salts, potassium salts, lithium salts, magnesium salts, and calcium salts, and basic amino acids such as ammonium salts, arginine salts, and histamine salts, and ammonium salts. Organic salts such as triethanolamine salt and diisopropanolamine salt. In the present invention, it is particularly preferred to use sodium hyaluronate. Hyaluronic acid can be produced by culturing a microorganism or by extracting it from a tissue containing hyaluronic acid. Commercially available products can also be used, and such commercially available products include, for example, Bio Hyaluronate ΗΑ12 (manufactured by Shiseido Co., Ltd.). The content of hyaluronic acid is not particularly limited, and is preferably 0.001 to 5% by weight based on the total amount of the emulsified composition, more preferably 0.005 to 2% by weight, most preferably 0.01 to 1% by weight. In the present invention, acetylated hyaluronic acid refers to a derivative obtained by hydroxyethylating at least a part of hyaluronic acid and a salt thereof. In the present invention, the molecular weight of the acetylated hyaluronic acid used is not particularly limited, but it is preferably from 10,000 to 50,000 and more preferably from 100,000 to 20,000. Further, the oxime conversion ratio of the hydroxy group is not particularly limited. However, in the above-mentioned repeating structural unit represented by the general formula (I), the number of substitutions of the ethane group is preferably 2 to 4 on average. Examples of the hyaluronic acid hyaluronate include metal salts such as sodium salts, potassium salts, lithium salts, magnesium salts, and calcium salts, and the base salts such as the persalt, -8 - 200817040 arginine, and histidine. An organic salt such as an amino acid, an ammonium salt, a triethanolamine salt or a diisopropanolamine salt. The acetylated hyaluronic acid can be produced by a method known to a person skilled in the art, and the method is disclosed in, for example, JP-A-6-6707 and JP-A-8-5 3 0 1 . Commercially available products can also be used, and such commercially available products include, for example, sodium acetal hyaluronate (manufactured by Shiseido Co., Ltd.). The amount of the ethoxylated hyaluronic acid is not particularly limited, but it is preferably 0.0001 to 1% by weight based on the total amount of the emulsified composition, more preferably 0.0002 to 0.1% by weight, and most preferably 0.0005 to 0.01% by weight. In the emulsified composition of the present invention, the relative proportion of the amount of the brown algae extracting gel and the acetylated hyaluronic acid is not particularly limited. From the viewpoint of improving the degree of smoothness, when the amount of acetylated hyaluronic acid is set to 1, the brown algae extracting gel is preferably 0.01 to 50000, more preferably 0.1 to 100 00, and particularly preferably 10 to 1000. Further, the relative ratio of hyaluronic acid to acetylated hyaluronic acid is not particularly limited. From the viewpoint of the feeling of use such as the degree of smoothness, when the amount of the acetylated hyaluronic acid is set to 1, the hyaluronic acid is preferably 0.01 to 10,000, more preferably 0.1 to 1,000, and more preferably 1 to 100. The emulsified form of the composition is applicable to both the oil-type emulsified composition in the oil and the water-based emulsified composition in the oil, or the water-based emulsified composition in the oil, and the oil-based emulsified composition in the oil, and the like. From the viewpoint of obtaining a good feeling of use such as a refreshing feeling, it is preferred to use an oily emulsified composition in water. In the emulsified composition of the present invention, the relative ratio of the water content to the oil content is not particularly limited. However, from the viewpoint of obtaining a good feeling of use such as a refreshing feeling, the moisture: oil content (mass ratio) = 2: 1 to 100: 1 is better, moisture: oil (mass ratio) = 4: 1 to 50: 1 is better. -9- 200817040 The oil component contained in the emulsified composition of the present invention may, for example, be avocado oil, macadamia nut oil, maize oil, olive oil, rapeseed oil, evening primrose oil, castor oil, sunflower oil, tea. Seed oil, camellia oil, rice bran germ oil, jojoba oil, cocoa butter, coconut oil, stearic acid, cetyl alcohol, 1,3-butylene glycol, squalene, tallow, wood wax, candied fruit, survey Deli, palmetto, whale, sheep fat, mobile paraffin, polyoxyethylene (8 mol) oleyl alcohol ether, glycerol monooleate, octyl dodecanoate, cyclomethicone, Dimethyl polyoxyalkylene, diphenyl polyoxyalkylene, etc., especially camellia oil, jojoba oil, squalene, stearic acid, whale sterol, octyl dodecyl citrate, 1 3-butyl diol is preferred. Further, the amount of the oil is preferably from 0.5 to 40% by weight based on the total amount of the emulsified composition, more preferably from 2 to 30% by weight, particularly preferably from 3 to 20% by weight. By limiting the amount of the oil component in the emulsified composition to the above range, the feeling of stickiness when the composition is used can be suppressed, and the feeling of use can be improved. The emulsified composition of the present invention may further contain an emulsifier which increases the emulsion stability. The emulsifier is not particularly limited as long as it can be used for external use on the skin, and examples thereof include an anionic surfactant such as an alkyl sulfate, a decylamino acid salt or a fatty acid salt, and a polyoxyalkylene alkyl ether. Nonionic surfactants such as polyoxyalkylene fatty acid esters, polyoxyalkylene polyol fatty acid esters, polyhydric alcohol fatty acid esters, sucrose fatty acid esters, cationic surfactants such as tetraalkylammonium salts, and beets An amphoteric surfactant such as a base type, a thiobetaine type, a thiomethic acid type, an imidazolium type, a lecithin, or a defatted acid lecithin is particularly preferably a monostearic acid glyceride or a hydrogenated soybean phospholipid. The emulsified composition of the present invention can be further blended with a whitening component, an anti--10-200817040 inflammatory component, an antioxidant component, a tackifier, a preservative, a stabilizer, a moisturizer, a pH adjuster, a perfume, and the like. Examples of the whitening component include ascorbic acid and derivatives thereof, salts thereof, vitamin A or derivatives thereof, pantothenic acid or derivatives thereof, hydroquinone and its derivatives such as arbutin, ellagic acid, citric acid, and orcinol. Resin phenol and its derivatives, chamomile, histidine and its derivatives and its salts, licorice flavonoids, glycyrrhizin, glycyrrhizin, isoliquiritin, ferulic acid and its derivatives, and its salts, caffeic acid and its derivatives And its salt. Examples of the extract include animal extracts such as clam shell extract, placenta extract, liver extract, chamomile extract, carotenoid extract, asparagus extract, pea extract, sassafras extract, and astragalus extract. , stalk flower extract, seaweed extract, raspberry extract, Sophora flavescens extract, spatholobus extract, schisandra extract, coffee extract, rice bran extract, wheat germ extract, asarum extract , Mountain Chass Extract, Mountain Lentil Extract, White Lily Extract, Paeonia Extract, Overhang Flower Extract, Soy Extract, Tea Extract, Molasses Extract, Tomato Extract, Angelica Extract, White Wood Seedling Extracts, grape extract, hop extract, rose extract, saxifrage extract, eucalyptus extract, hazelnut extract, and mangosteen extract. Examples of anti-inflammatory ingredients include urinary strontium, smithite, glycyrrhizic acid or its derivatives, glycyrrhetinic acid or its derivatives, zinc oxide, yanoxiol, tocopherol acetate, vitamin B6, menthol, camphor, and turpentine. , sesame, salicylic acid or its derivatives. Antioxidant components include tocopherol and its derivatives, hydroxyanisuccinate, dibutylhydroxytoluene, sodium hydrogen sulfite, isoascorbic acid and its salts, -11 - 200817040 flavonoids, glutamine sulfur, glutamine Thiol peroxidase, glutamine-sulfur-S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, sulfur taurine, hypotaurine, and the like. Examples of the tackifier include sodium carboxymethylcellulose, a carboxyvinyl polymer and/or a salt thereof, hydroxyethylcellulose, staghorn gum, sodium formate, tridentate, sodium polyacrylate, polyvinyl alcohol, locust bean gum, Guar gum, gelatin, hydroxypropyl methylcellulose, and the like. Among them, a carboxyvinyl polymer and/or a salt thereof can be used as appropriate. The carboxyvinyl polymer is a water-soluble polymer having a carboxyl group and is a polymer of acrylic acid. The carboxyvinyl polymer and/or its salt is viscous by neutralizing its aqueous solution with an alkali solution. The carboxyvinyl polymer used in the present invention is not particularly limited, but a 0.2% aqueous solution viscosity is preferably in the range of from 1 000 to 50,000 mPa·s, particularly preferably in the range of from 5,000 to 30,000 mPa·s. The carboxyvinyl polymer can be produced by polymerizing acrylic acid according to a commonly used method. In the present invention, a commercially available product may be used. Examples of such commercially available products include Carbopol 980, Carbopol 981, Carbopol 2984, Carbοροί 5 984, Carbopol ETD 2050, Carbopol ultrez 10 (manufactured by Noveon Corporation), and Haibesewako- 103, Haibesewako-104, Haibesewako-105, Shitaren K, Shitaren L (manufactured by Wako Pure Chemical Industries, Ltd.), and a urethane hose (manufactured by Nippon Pure Chemical Co., Ltd.). The carboxyvinyl polymer has an effect of improving the viscosity stability due to emulsification stability and temperature change, and is particularly suitable for use in the form of a gel composition and a cream composition. Further, the carboxyvinyl polymer has a moisturizing action and is less susceptible to microbial contamination, and has an excellent quality uniformity compared with the natural rubber type -12-200817040. The content of the carboxyvinyl polymer is not particularly limited, but it is preferably 0. 01 to 5% by weight based on the total amount of the emulsified composition, more preferably 2 to 2% by weight, and most preferably 0.05 to 1% by weight. The preservative may, for example, be a paraben or a benzyldimethylammonium chloride. Examples of the stabilizer include sodium sulfite, sodium hydrogen sulfite, dibutylhydroxytoluene, butyl thioanisole, ethylenediaminetetraacetic acid or a salt thereof.

Examples of the humectant include polyhydric alcohols such as glycerin, ethylene glycol, propylene glycol, 1,3-butanediol, isopropyl glycol, and polyethylene glycol. Examples of the pH adjuster include inorganic acids such as hydrochloric acid, organic acids such as citric acid, alkali hydroxides such as potassium hydroxide and sodium hydroxide, triethanolamine, diethanolamine, and perfumes, which include spearmint oil, pepper oil, and linalool. Natural spices such as wintergreen oil, foreign rub oil, clove oil, peppermint oil, thyme oil, sage oil, blue eucalyptus oil, lavender oil, peppermint oil, cinnamon oil, lime oil, lemon oil and citrus oil - menthol, dl-camphor, etc. The dosage form of the emulsified composition of the present invention is not particularly limited, and examples thereof include a cream, an emulsion, an emulsion, an emulsion ointment, and the like, and particularly, a cream, an emulsion, and an emulsion are preferred. The emulsified composition of the present invention can be produced by mixing an essential component such as an emulsifier in an aqueous phase or an oil phase, heating and dissolving as necessary, and then mixing and emulsifying the aqueous phase and the oil phase. The emulsification method used in the present invention may be carried out by a general emulsification method, or may be carried out by using a colloid honing machine, a homogenizer, a high pressure homogenization base, an ultrasonic emulsifier or the like. -13- 200817040 The emulsified composition of the present invention can be applied to skin external preparations such as skin external cosmetics and therapeutic agents for dry skin diseases, for example, by the degree of smoothness and moisturizing effect at the time of use, but the present invention is Not limited to this. The amount and frequency of use of the emulsified composition of the present invention are not particularly limited, and may be appropriately selected depending on the purpose of use. [Embodiment] EXAMPLES Hereinafter, the present invention will be specifically described by way of Examples, but the present invention is not limited thereto. [Example 1] O.lg's brown algae extract (brown algae extract: BOTTGER), 〇.〇5g of sodium hyaluronate (Bio sodium hyaluronate HA12: manufactured by Shiseido Co., Ltd., molecular weight 1.1 million to 1.6 million), 0· 005 g of acetaminophen sodium hyaluronate (sodium ethoxylated sodium hyaluronate: manufactured by Shiseido Co., Ltd., molecular weight of about 10,000, acetylation rate of 2.8 to 3.8), concentrated glycerol of lg, 0.3 g of carboxyvinyl polymer (Carbopol Ultrez 10 : Noveon Corporation, viscosity 16,000 to 28,000 mPa·s (0.2%)) and 0.25 g of potassium hydroxide were added to 86.7 g of purified water to make it an aqueous phase heated to 80 °C. In addition, 3 g of stearic acid, 4 g of camellia oil, 4 g of jojoba oil, 2 g of cetyl alcohol, 3 g of squalene, and 1 g of monostearic acid ester (曰) Light MGS-BMV: manufactured by Nikko Chemical Co., Ltd., which is used as an oil phase by mixing it with heat to 80 °C. The oil phase was added to the aqueous phase, stirred at 80 ° C, mixed and emulsified, and then cooled to below 30 ° C to prepare a cream. -14- 200817040 [Comparative Examples 1 to 3] The acetylated sodium hyaluronate in Example 1 was replaced with water as a comparative example 1, and the sodium hyaluronate was replaced with water as a comparative example 2 'The brown algae extract was replaced with water and used as the cream of Comparative Example 3. [Comparative Examples 4 to 6] The components of the brown algae extract gel, sodium hyaluronate, and sodium acetal hyaluronate in Example 1 were replaced with water, and the results were as Comparative Example 4, Comparative Example 5, and Comparative Example 6, The above-mentioned three components were replaced with water and used as a control to prepare a cream. [Test Example] The creams produced in Example 1 and Comparative Examples 1 to 6 were evaluated for their feeling of use. The use of the sensory system was tested by one subject, and the degree of smoothness was evaluated on the basis of the following criteria, and the average point was used for the determination. Further, the degree of smoothness as described above is related to the feeling of friction felt by the skin applied to the finger or the applied portion at the time of application, and it is considered that the emulsion composition of the present invention is thinly spread. And related to the viscosity after drying. Thus, the degree of lubrication of the emulsified composition of the present invention at the time of use was evaluated by measuring the viscosity at the time of drying. Specifically, for the creams produced in Example 1 and Comparative Examples 1 to 6, 1 g of the sample was uniformly spread on a circular plate having a diameter of 4 cm by using RHEO METER (AR-1 000 N ). Test -15- 200817040 On the sample stand, after drying for 5 minutes in a dryer, the viscosity was measured at a measurement temperature of 25 ° C and a shear force of 50 A, and the same test was performed on the control cream. . [Criteria for Judgment] Lubricity: After applying the composition of the external preparation to the skin of the finger and fully pushing it out, the friction feeling when the coated portion is rubbed against other fingers is evaluated. [Evaluation Criteria] 5 points: Very good (no feeling of friction, fingers can move smoothly) 4 points: Good (nearly feel no friction) 3 points: Normal (slightly felt friction) 2 points: Bad (feeling Friction) 1 point: Very bad (feeling strong friction, finger knotting) [Judgement] 〇: Average point 4.7 or more A: Average point 3.5 or more is less than 4.7 X: Average point is less than 3.5 Test results are shown in the table 1. -16- 200817040

t-Η撇 collocation amount (g) Control 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Total amount l〇〇g X 6.377 Comparative Example 6 0.1 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Total amount l〇〇g Δ 2.421 Comparative Example 5 0.05 1.0 0.3 0.25 3.0 4.0 0.4 0,2 3.0 1.0 Total amount l〇〇g △ 1.115 Comparative Example 4 0.005 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Total amount 100g X 12.910 Comparative example 3 0.05 0.005 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Full amount 100g ! △ 0.985 Comparative Example 2 0.1 0.005 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Total 100g 1 1 △ 2.546 Comparative Example 1 1 0.1 0.05 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Full amount l〇〇g X 3.085 ---- ----------—| Example 1 i 0.1 0.05 0.005 1.0 0.3 0.25 3.0 4.0 0.4 0.2 3.0 1.0 Total 100g 〇0.510 Ingredients _ 啦 S 胜 胜 扭 扭 霾澎 霾澎 霾澎 霾澎 截 截 垣瀣 垣瀣Warm and stupid slightly distilled 靼 靼 酲 ) ) ) 澎 澎 澎 € € € € GO GO GO GO GO - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Example 1, Comparative Example 2, containing brown algae extraction gel and sodium acetylated hyaluronic acid, containing sodium hyaluronate and acetamidine Comparative Example 3 of sodium hyaluronate, Comparative Example 4 containing only acetaminophen sodium hyaluronate, Comparative Example 5 containing only sodium hyaluronate, and the cream of Comparative Example 6 containing only brown algae extraction gel, the smoothness at the time of use was △ (ordinary) to x (poor), the cream of Example 1 containing brown algae extract gel, sodium hyaluronate and sodium sulfonate hyaluronic acid, the slipperiness when used was 〇 (good). In addition, in Comparative Example 1 containing brown algae extract gel and sodium hyaluronate, Comparative Example 2 containing brown algae extract gel and sodium hyaluronate hyaluronic acid, Comparative Example 3 containing sodium hyaluronate and sodium hyaluronate, only containing acetamidine Comparative Example 4 of sodium hyaluronate, Comparative Example 5 containing only sodium hyaluronate, and the cream of Comparative Example 6 containing only brown algae extraction gel, the viscosity at the time of drying was 3.0 8 5, 2.5 46, 0.9 8 5, 12.910, respectively. The sorghum of 1.115 and 2.421, the cream of the first embodiment containing brown algae extracting gel, sodium hyaluronate and sodium acetylated hyaluronate, has a viscosity of 0.510 at the time of drying. It is apparent that the viscosity after coating becomes low. From these results, it is clear that the emulsifier composition contained in the brown algae extract gel, sodium hyaluronate and sodium hyaluronate has an excellent degree of smoothness when used. [Example 2] O.lg brown algae extract (brown algae extract: manufactured by BOTTGER), 〇.〇5g of sodium hyaluronate (Bio sodium hyaluronate HA12: manufactured by Shiseido Co., Ltd.), 0.001 g of sodium acetal hyaluronate ( Acetyl hyaluronate: manufactured by Shiseido Co., Ltd., lg concentrated glycerin, 2 g of 1,3-butanediol, 0.15 g of carboxyethyl-18-200817040 burned polymer (Carbopol ETD2050: manufactured by Noveon, viscosity 4,000~7,500 mPa · s (0_2%)) and 27.27 g of potassium hydroxide were added to 87.4 g of purified water to make it an aqueous phase heated to 8 °C. In addition, 2 g of stearic acid, 2 g of camellia oil, 4 g of jojoba oil, 3 g of whale sterol, 2 g of octyl dodecanoate, 2 g of squalene 'and 〇. 3g of monostearic acid glyceride (Daylight MGS-BMV: manufactured by Nikko Chemical Co., Ltd.), which was mixed with heat to 80 ° C as an oil phase. The oil phase was added to the aqueous phase, stirred at 80 ° C, mixed and emulsified, and then cooled to below 3 ° C to prepare an emulsion. Ten subjects were tested in the same manner as the above-mentioned experimental examples. The results are shown in Table 2.

-19- 200817040

Ingredient Example 2 (g) Brown algae extract 0.1 Sodium hyaluronate 0.0 5 Acetyl hyaluronate 0.00 1 Concentrated glycerol 1.0 1,3-butanediol 2.0 Carboxyvinyl polymer 0.15 Potassium hydroxide 0.2 7 Stearate 2.0 Camellia oil 2.0 Jojoba oil 0.4 whale sterol 0.3 octyl dodecanoate 2.0 squalene 2.0 glyceryl monostearate 0.3 purified water total amount 00g Evaluation of the project smoothness 〇 From these results, it is clear that brown algae extract The emulsion of Example 2 contained in both sodium hyaluronic acid and sodium acetylated hyaluronate was used for smoothing. [Example 3] 0.5 g of hydrogenated soybean phospholipid (PHOSPHOLIPON 90H: manufactured by H. Holstein·AND) was added to 5 g. The 1,3-butanediol was dissolved at 65 ° C and then cooled to 30 ° C and used as an oil phase. In addition, O.lg's brown algae extracting gel (褊藻提取胶: ^〇丁丁0£用制制制制), -20- 200817040 〇.〇5g of sodium hyaluronate (Bio sodium hyaluronate HA12: manufactured by Shiseido Co., Ltd.), 0.001 B Sodium hyaluronate (sodium sulphate hyaluronic acid · Shiseido Co., Ltd.), 〇·1 g of thioglycolate polymer (Shitaren L: Wako Pure Chemical Industries, Ltd., viscosity 7,000 ~ 14,000 mPa · s (0.2%)) 3 g of concentrated glycerin, and 〇· 4 4 g of potassium hydroxide were added to 9 1.2 g of purified water, and stirred at room temperature to make it an aqueous phase. The aqueous phase is then added to the oil phase at 30. (: stirring and mixing were carried out to prepare an emulsion. The evaluation of the feeling of use of the obtained emulsion was carried out in the same manner as in the above-mentioned experimental examples, and the results are shown in Table 3.

Ingredient Example 32 (g) Brown algae extract 0.1 Sodium hyaluronate 0.05 Ethyl hyaluronate 0.001 Hydrogenated soybean phospholipid 0.5 1,3-butanediol 5.0 Carboxyvinyl polymer 0.10 Concentrated glycerol 3.0 Potassium argon oxide 0.044 Purified water total amount 1 0 0 g Evaluation of the smoothness of the evaluation of the item It is clear from these results that the emulsion of Example 3 contained in the brown algae extract gel, sodium hyaluronate and sodium ethionate hyaluronic acid has a smooth feeling of use. -21 - 200817040 The present invention provides an emulsified composition containing a brown algae extractant and hyaluronic acid, which has a smooth feeling of use. The emulsified composition of the present invention can be used in the cosmetics industry as a skin external cosmetic or the like, and can be used as a therapeutic agent for dry skin diseases in the pharmaceutical industry, and has industrial applicability.

•twenty two-

Claims (1)

200817040 X. Patent application scope 1 · An emulsified composition containing brown algae extract gel, hyaluronic acid and acetaminophen hyaluronic acid. 2. The emulsified composition of claim 1, wherein the emulsified composition is an oily emulsified composition in water. 3. The emulsified composition according to claim 1 or 2, which is a skin external preparation. -23- 200817040 VII. Designated representative map (1) The designated representative figure of this case is: None (2), the representative symbol of the representative figure is a simple description: 8. If there is a chemical formula in this case, please reveal the chemical formula that best shows the characteristics of the invention: none -4-