TW200800987A - Triazolopyridine derivatives as inhibitors of lipases and phospholipases - Google Patents

Triazolopyridine derivatives as inhibitors of lipases and phospholipases

Info

Publication number: TW200800987A
Authority: TW; Taiwan
Prior art keywords: phospholipases; lipases; inhibitors; triazolopyridine derivatives; triazolopyridine
Prior art date: 2005-10-19

Application number

TW095138144A

Other languages

English (en)

Inventor

Stefan Petry

Gerhard Zoller

Guenter Mueller

Karl-Heinz Baringhaus

Hubert Heuer

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-19

Filing date

2006-10-17

Publication date

2008-01-01

2006-10-17 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2008-01-01 Publication of TW200800987A publication Critical patent/TW200800987A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Biotechnology (AREA)
Ophthalmology & Optometry (AREA)
Psychology (AREA)

TW095138144A 2005-10-19 2006-10-17 Triazolopyridine derivatives as inhibitors of lipases and phospholipases TW200800987A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102005049954A DE102005049954A1 (de)	2005-10-19	2005-10-19	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen

Publications (1)

Publication Number	Publication Date
TW200800987A true TW200800987A (en)	2008-01-01

Family

ID=37487398

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW095138144A TW200800987A (en)	2005-10-19	2006-10-17	Triazolopyridine derivatives as inhibitors of lipases and phospholipases

Country Status (26)

Country	Link
US (2)	US7718669B2 (zh)
EP (1)	EP1940838B1 (zh)
JP (1)	JP2009512649A (zh)
KR (1)	KR20080057299A (zh)
CN (1)	CN101291932A (zh)
AR (1)	AR058095A1 (zh)
AU (1)	AU2006303551A1 (zh)
BR (1)	BRPI0617712A2 (zh)
CA (1)	CA2625442A1 (zh)
CR (1)	CR9851A (zh)
DE (1)	DE102005049954A1 (zh)
DO (1)	DOP2006000227A (zh)
EC (1)	ECSP088376A (zh)
HN (1)	HN2006035237A (zh)
IL (1)	IL190715A0 (zh)
MA (1)	MA29857B1 (zh)
MY (1)	MY140514A (zh)
NO (1)	NO20082159L (zh)
NZ (1)	NZ567574A (zh)
PE (1)	PE20070820A1 (zh)
RU (1)	RU2008119435A (zh)
TN (1)	TNSN08178A1 (zh)
TW (1)	TW200800987A (zh)
UY (1)	UY29878A1 (zh)
WO (1)	WO2007045392A1 (zh)
ZA (1)	ZA200802369B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102005049954A1 (de) *	2005-10-19	2007-05-31	Sanofi-Aventis Deutschland Gmbh	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen
DK1976828T3 (en)	2005-12-29	2017-03-06	Celtaxsys Inc	DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE
FR2915199B1 (fr)	2007-04-18	2010-01-22	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
FR2915197B1 (fr) *	2007-04-18	2009-06-12	Sanofi Aventis Sa	Derives de triazolopyridine-carboxamides, leur preparation et leur application therapeutique.
FR2915198B1 (fr)	2007-04-18	2009-12-18	Sanofi Aventis	Derives de triazolopyridine-carboxamides et triazolopyridine -carboxamides, leur preparation et leur application en therapeutique.
EP2025674A1 (de)	2007-08-15	2009-02-18	sanofi-aventis	Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
UY31968A (es)	2008-07-09	2010-01-29	Sanofi Aventis	Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
EP2351744B1 (en) *	2008-10-17	2015-01-07	Shionogi & Co., Ltd.	Acetic acid amide derivative having inhibitory activity on vascular endothelial lipase
AR075111A1 (es) *	2008-12-24	2011-03-09	Bial Portela & Ca Sa	Derivados heterociclicos de diazoles y triazoles, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de trastornos del metabolismo y del sistema nervioso, entre otros.
KR20120123325A (ko)	2009-12-15	2012-11-08	시오노기세야쿠 가부시키가이샤	혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체
NZ604035A (en)	2010-06-04	2015-02-27	Albany Molecular Res Inc	Glycine transporter-1 inhibitors, methods of making them, and uses thereof
US8933024B2 (en)	2010-06-18	2015-01-13	Sanofi	Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US9333202B2 (en)	2012-05-01	2016-05-10	The Trustees Of Columbia University In The City Of New York	Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease
JP6527851B2 (ja)	2013-03-12	2019-06-05	セルタクシス，インコーポレイテッド	ロイコトリエンａ４加水分解酵素を阻害する方法
KR20150127245A (ko)	2013-03-14	2015-11-16	켈탁시스, 인코퍼레이티드	류코트라이엔 a4 가수분해효소의 저해제
US9938291B2 (en)	2013-03-14	2018-04-10	The Trustess Of Columbia University In The City Of New York	N-alkyl-2-phenoxyethanamines, their preparation and use
EP2968265A4 (en)	2013-03-14	2016-12-28	Celtaxsys Inc	INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE
AU2014239567B2 (en)	2013-03-14	2017-12-14	Celtaxsys, Inc.	Inhibitors of leukotriene A4 hydrolase
WO2014151936A1 (en)	2013-03-14	2014-09-25	The Trustees Of Columbia University In The City Of New York	Octahydropyrrolopyrroles, their preparation and use
ES2705247T3 (es)	2013-03-14	2019-03-22	Univ Columbia	4-fenilpiperidinas, su preparación y uso
EP2968303B1 (en)	2013-03-14	2018-07-04	The Trustees of Columbia University in the City of New York	Octahydrocyclopentapyrroles, their preparation and use
WO2015061272A1 (en) *	2013-10-22	2015-04-30	Bristol-Myers Squibb Company	Isotopically labeled triazolopyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
AU2015253232B2 (en)	2014-04-30	2020-10-01	The Trustees Of Columbia University In The City Of New York	Substituted 4-phenylpiperidines, their preparation and use
JOP20180094A1 (ar)	2017-10-18	2019-04-18	Hk Inno N Corp	مركب حلقي غير متجانس كمثبط بروتين كيناز
JP7386815B2 (ja)	2018-05-31	2023-11-27	セルタクシー、エルエルシー	呼吸器疾患患者の肺増悪を軽減する方法
KR102195348B1 (ko)	2018-11-15	2020-12-24	에이치케이이노엔 주식회사	단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물
CN117126134A (zh) *	2022-05-20	2023-11-28	中国科学院上海药物研究所	新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

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Publication number	Priority date	Publication date	Assignee	Title
GB0100624D0 (en) *	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds VII
DE10247680B4 (de) *	2002-10-12	2005-09-01	Aventis Pharma Deutschland Gmbh	Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase
DE102004005172A1 (de) *	2004-02-02	2005-08-18	Aventis Pharma Deutschland Gmbh	Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
DE102005049954A1 (de) *	2005-10-19	2007-05-31	Sanofi-Aventis Deutschland Gmbh	Triazolopyridin-derivate als Inhibitoren von Lipasen und Phospholipasen

2005
- 2005-10-19 DE DE102005049954A patent/DE102005049954A1/de not_active Withdrawn
2006
- 2006-10-12 KR KR1020087009354A patent/KR20080057299A/ko not_active Withdrawn
- 2006-10-12 CN CNA200680039028XA patent/CN101291932A/zh active Pending
- 2006-10-12 AU AU2006303551A patent/AU2006303551A1/en not_active Abandoned
- 2006-10-12 NZ NZ567574A patent/NZ567574A/en not_active IP Right Cessation
- 2006-10-12 BR BRPI0617712-3A patent/BRPI0617712A2/pt not_active IP Right Cessation
- 2006-10-12 CA CA002625442A patent/CA2625442A1/en not_active Abandoned
- 2006-10-12 WO PCT/EP2006/009856 patent/WO2007045392A1/de not_active Ceased
- 2006-10-12 MY MYPI20081120A patent/MY140514A/en unknown
- 2006-10-12 RU RU2008119435/04A patent/RU2008119435A/ru not_active Application Discontinuation
- 2006-10-12 JP JP2008535941A patent/JP2009512649A/ja not_active Abandoned
- 2006-10-12 EP EP06806215A patent/EP1940838B1/de active Active
- 2006-10-17 DO DO2006000227A patent/DOP2006000227A/es unknown
- 2006-10-17 PE PE2006001256A patent/PE20070820A1/es not_active Application Discontinuation
- 2006-10-17 TW TW095138144A patent/TW200800987A/zh unknown
- 2006-10-17 AR ARP060104518A patent/AR058095A1/es not_active Application Discontinuation
- 2006-10-18 HN HN2006035237A patent/HN2006035237A/es unknown
- 2006-10-19 UY UY29878A patent/UY29878A1/es not_active Application Discontinuation
2008
- 2008-03-13 ZA ZA200802369A patent/ZA200802369B/xx unknown
- 2008-03-28 CR CR9851A patent/CR9851A/es not_active Application Discontinuation
- 2008-04-08 IL IL190715A patent/IL190715A0/en unknown
- 2008-04-08 MA MA30824A patent/MA29857B1/fr unknown
- 2008-04-09 US US12/099,922 patent/US7718669B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008376A patent/ECSP088376A/es unknown
- 2008-04-18 TN TNP2008000178A patent/TNSN08178A1/en unknown
- 2008-05-08 NO NO20082159A patent/NO20082159L/no not_active Application Discontinuation
2010
- 2010-03-25 US US12/731,225 patent/US20100190801A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PE20070820A1 (es)	2007-09-04
AR058095A1 (es)	2008-01-23
JP2009512649A (ja)	2009-03-26
NZ567574A (en)	2010-03-26
ZA200802369B (en)	2009-01-28
KR20080057299A (ko)	2008-06-24
BRPI0617712A2 (pt)	2011-08-02
US20100190801A1 (en)	2010-07-29
HN2006035237A (es)	2010-03-11
US7718669B2 (en)	2010-05-18
EP1940838A1 (de)	2008-07-09
ECSP088376A (es)	2008-05-30
US20090030011A1 (en)	2009-01-29
IL190715A0 (en)	2008-11-03
EP1940838B1 (de)	2012-08-22
CN101291932A (zh)	2008-10-22
MY140514A (en)	2009-12-31
RU2008119435A (ru)	2009-11-27
MA29857B1 (fr)	2008-10-03
DOP2006000227A (es)	2007-05-15
AU2006303551A1 (en)	2007-04-26
CR9851A (es)	2008-07-29
WO2007045392A1 (de)	2007-04-26
CA2625442A1 (en)	2007-04-26
TNSN08178A1 (en)	2009-10-30
NO20082159L (no)	2008-05-08
UY29878A1 (es)	2007-05-31
DE102005049954A1 (de)	2007-05-31

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