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TW200800966A - Beta-secretase modulators and methods of use - Google Patents

Beta-secretase modulators and methods of use

Info

Publication number
TW200800966A
TW200800966A TW095143035A TW95143035A TW200800966A TW 200800966 A TW200800966 A TW 200800966A TW 095143035 A TW095143035 A TW 095143035A TW 95143035 A TW95143035 A TW 95143035A TW 200800966 A TW200800966 A TW 200800966A
Authority
TW
Taiwan
Prior art keywords
compounds
beta
methods
formula
treatment
Prior art date
Application number
TW095143035A
Other languages
Chinese (zh)
Inventor
Wenge Zhong
Stephen Hitchcock
Brian K Albrecht
Michael Bartberger
James Brown
Ryan Brown
Stuart Charles Chaffee
Yuan Cheng
Michael Croghan
Russell Graceffa
Scott Harried
Dean Hickman
Dan Horne
Randall Hungate
Ted Judd
Matthew Kaller
Charles Kreiman
Daniel La
Patricia Lopez
Holger Monenschein
Thomas Nguyen
Thomas Nixey
Vinod F Patel
Lewis Pennington
Matthew Weiss
Qiufen Xue
Bryant Yang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39708735&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200800966(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of TW200800966A publication Critical patent/TW200800966A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I Wherein A, B, W, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
TW095143035A 2005-11-21 2006-11-21 Beta-secretase modulators and methods of use TW200800966A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73910805P 2005-11-21 2005-11-21
US85482406P 2006-10-27 2006-10-27

Publications (1)

Publication Number Publication Date
TW200800966A true TW200800966A (en) 2008-01-01

Family

ID=39708735

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095143035A TW200800966A (en) 2005-11-21 2006-11-21 Beta-secretase modulators and methods of use

Country Status (8)

Country Link
EP (1) EP1971598A1 (en)
JP (1) JP5274258B2 (en)
AR (1) AR057985A1 (en)
AU (1) AU2006316620B2 (en)
CA (1) CA2629402C (en)
PE (1) PE20070645A1 (en)
TW (1) TW200800966A (en)
WO (1) WO2007061670A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
TW200901991A (en) * 2007-05-25 2009-01-16 Amgen Inc Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
MX2009012608A (en) * 2007-05-25 2009-12-07 Amgen Inc Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use.
US8946483B2 (en) 2011-07-21 2015-02-03 Ge Healthcare Limited Precursor compounds and methods for making same
BR112014023384A8 (en) * 2012-03-20 2018-01-16 R Artis Dean spirocyclic bace inhibitors of dihydro-thiazine and dihydro-oxazine, and compositions and uses thereof.
EP3170820B1 (en) 2014-07-16 2019-02-20 Japan Science and Technology Agency Benzothiazole compound and medicine containing same
JP7413346B2 (en) 2019-03-06 2024-01-15 第一三共株式会社 Pyrrolopyrazole derivative

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY138097A (en) 2000-03-22 2009-04-30 Du Pont Insecticidal anthranilamides
ATE314343T1 (en) 2000-06-30 2006-01-15 Elan Pharm Inc COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
US7196163B2 (en) 2001-05-22 2007-03-27 Merk & Co., Inc. Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity
JP2005500319A (en) 2001-06-27 2005-01-06 イーラン　ファーマスーティカルズ、インコーポレイテッド Β-hydroxyamine derivatives useful for the treatment of Alzheimer's disease
KR100713137B1 (en) 2001-06-28 2007-05-02 동화약품공업주식회사 Novel 2,4-difluorobenzamide derivatives
BR0211118A (en) 2001-07-10 2004-10-26 Elan Pharm Inc Compound, methods for treating or preventing disease and for making a compound, intermediate, and use of a compound or salt
BR0211122A (en) 2001-07-10 2004-10-26 Elan Pharm Inc Compound, methods for treating or preventing disease and for making a compound, intermediate, and use of a compound or salt
MXPA04000334A (en) 2001-07-11 2004-09-28 Elan Pharm Inc N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds.
MXPA04003245A (en) 2001-10-04 2004-08-11 Elan Pharm Inc Hydroxypropylamines.
BR0213138A (en) 2001-10-05 2004-08-24 Elan Pharm Inc Methods of treating or preventing alzheimer's disease and a disease distinguished by beta-amyloid deposition in the brain, treating a patient who has, or preventing a patient from contracting a disease or condition, producing a beta-secretase complex and inhibit beta-amyloid plaque production in an animal, composition and use of a compound
MXPA04004079A (en) 2001-10-29 2005-07-05 Pharmacia & Upjohn Co Llc Hydroxy substituted amides for the treatment of alzheimer's disease.
RS50504A (en) 2001-11-08 2007-04-10 Elan Pharmaceuticals Inc., N,n'-substituted-1,3-diamino-2- hydroxypropane derivatives
AR037460A1 (en) 2001-11-30 2004-11-10 Smithkline Beecham Plc HYDROXYETHYLENE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT, USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND PROCEDURE FOR PREPARATION
BR0214736A (en) 2001-12-06 2004-11-23 Elan Pharm Inc Compound and its pharmaceutically acceptable salts, pharmaceutical composition and method of treating humans or animals suffering from diseases or conditions
BR0306724A (en) 2002-01-04 2006-04-11 Elan Pharm Inc amino substituted carboxamides for treatment of alzheimer's disease
JP2005526714A (en) 2002-01-17 2005-09-08 ニューロジェン・コーポレーション Substituted quinazolin-4-ylamine analogs as modulators of capsaicin
EP1515944A1 (en) 2002-06-17 2005-03-23 Sunesis Pharmaceuticals, Inc. Aspartyl protease inhibitors
US7115747B2 (en) 2002-06-20 2006-10-03 Pharmacia & Upjohn Company Process for preparing oxazole intermediates
UY27967A1 (en) 2002-09-10 2004-05-31 Pfizer 2-HINDROXI-1,3-DIAMINOALCANE OIL
US7362070B2 (en) 2002-11-04 2008-04-22 Hamilton Sundstrand Corporation Electric motor control system including position determination and error correction
EP1562897B1 (en) 2002-11-12 2009-09-16 Merck & Co., Inc. Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer s disease
CA2507484A1 (en) * 2002-11-27 2004-06-17 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
CA2512111A1 (en) 2003-01-07 2004-07-29 Merck And Co., Inc. Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease
CA2518886A1 (en) 2003-03-14 2004-09-23 Merck Sharp & Dohme Limited Method for treating mild cognitive impairment and for preventing or delaying alzheimer's disease
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
BRPI0409627A (en) 2003-04-21 2006-04-25 Elan Pharm Inc Phenacyl 2-hydroxy-3-diaminoalkanes
TW200512195A (en) 2003-04-21 2005-04-01 Elan Pharm Inc Benzamide 2-hydroxy-3-diaminoalkanes
GB0309221D0 (en) * 2003-04-23 2003-06-04 Glaxo Group Ltd Novel compounds
AU2003297826A1 (en) 2003-06-16 2005-01-28 Sunesis Pharmaceuticals, Inc Aspartyl protease inhibitors
WO2005004802A2 (en) 2003-06-30 2005-01-20 Merck & Co., Inc. N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease
EP1643986A4 (en) 2003-07-01 2009-04-08 Merck & Co Inc PHENYLCARBOXYLATE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
GB0317491D0 (en) * 2003-07-25 2003-08-27 Novartis Ag Organic compounds
CA2553973A1 (en) * 2004-01-21 2005-08-04 Elan Pharmaceuticals, Inc. Methods of treatment of amyloidosis using aspartyl-protease inihibitors
JP2007528403A (en) * 2004-03-09 2007-10-11 エラン ファーマシューティカルズ，インコーポレイテッド Methods for treating amyloidosis using bicyclic aspartic protease inhibitors
BRPI0509186A (en) * 2004-03-25 2007-08-28 Elan Pharm Inc 2-amino-and 2-thio-substituted 1,3-diaminopropanes

Also Published As

Publication number Publication date
AU2006316620A1 (en) 2007-05-31
CA2629402A1 (en) 2007-05-31
CA2629402C (en) 2011-07-26
AR057985A1 (en) 2008-01-09
AU2006316620B2 (en) 2011-03-03
EP1971598A1 (en) 2008-09-24
WO2007061670A1 (en) 2007-05-31
JP5274258B2 (en) 2013-08-28
JP2009516684A (en) 2009-04-23
PE20070645A1 (en) 2007-08-24

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