TW200745128A - Pyrazolopyrimidines as protein kinase inhibitors - Google Patents
Pyrazolopyrimidines as protein kinase inhibitorsInfo
- Publication number
- TW200745128A TW200745128A TW095136893A TW95136893A TW200745128A TW 200745128 A TW200745128 A TW 200745128A TW 095136893 A TW095136893 A TW 095136893A TW 95136893 A TW95136893 A TW 95136893A TW 200745128 A TW200745128 A TW 200745128A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- pyrazolopyrimidines
- protein kinase
- kinase inhibitors
- methods
- Prior art date
Links
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72415905P | 2005-10-06 | 2005-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200745128A true TW200745128A (en) | 2007-12-16 |
Family
ID=37671922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW095136893A TW200745128A (en) | 2005-10-06 | 2006-10-04 | Pyrazolopyrimidines as protein kinase inhibitors |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7645762B2 (zh) |
| EP (1) | EP1931675B1 (zh) |
| JP (1) | JP5102212B2 (zh) |
| CN (1) | CN101316847A (zh) |
| AR (1) | AR057979A1 (zh) |
| CA (1) | CA2624500A1 (zh) |
| TW (1) | TW200745128A (zh) |
| WO (1) | WO2007044407A2 (zh) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008132500A2 (en) * | 2007-04-27 | 2008-11-06 | Astrazeneca Ab | Chkl inhibitors with b cell depleting antibodies for the treatment of hematologic malignancies |
| CN101678002A (zh) | 2007-05-08 | 2010-03-24 | 先灵公司 | 使用含有替莫唑胺的静脉注射用配制剂的治疗方法 |
| US20110105457A1 (en) * | 2008-04-18 | 2011-05-05 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on pi3k |
| FR2933409B1 (fr) | 2008-07-03 | 2010-08-27 | Centre Nat Rech Scient | NOUVEAUX PYRROLO °2,3-a! CARBAZOLES ET LEUR UTILISATION COMME INHIBITEURS DES KINASES PIM |
| CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| PT3372605T (pt) * | 2008-10-22 | 2021-12-09 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk |
| EP2962566A1 (en) | 2008-10-31 | 2016-01-06 | Genentech, Inc. | Pyrazolopyrimidine jak inhibitor compounds and methods |
| NZ596571A (en) * | 2009-05-20 | 2013-03-28 | Cylene Pharmaceuticals Inc | Pyrazolopyrimidines and related heterocycles as kinase inhibitors |
| UA110324C2 (en) | 2009-07-02 | 2015-12-25 | Genentech Inc | Jak inhibitory compounds based on pyrazolo pyrimidine |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| JP2013503194A (ja) | 2009-08-28 | 2013-01-31 | アレイ バイオファーマ、インコーポレイテッド | Ｒａｆキナーゼを阻害するための１Ｈ−ピラゾロ［３，４−Ｂ］ピリジン化合物 |
| US20130131043A1 (en) * | 2010-04-30 | 2013-05-23 | Richard John Harrison | Pyrazole compounds as jak inhibitors |
| SMT201900203T1 (it) | 2010-05-20 | 2019-05-10 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| WO2012118978A1 (en) * | 2011-03-03 | 2012-09-07 | The Regents Of The University Of Colorado, A Body Corporate | Methods for treating oncovirus positive cancers |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| CN103073549A (zh) * | 2012-09-07 | 2013-05-01 | 苏州康润医药有限公司 | 3-溴吡唑啉[1,5-α]吡嘧啶-2-甲酸的合成工艺 |
| HRP20180859T1 (hr) | 2012-12-07 | 2018-07-13 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-(5-fluoro-4-(4-(4-(oksetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il)pirazolo[1,5alfa]pirimidin-3-karboksamid kao inhibitor atr kinaze |
| JP2016512239A (ja) * | 2013-03-15 | 2016-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
| EP2970288A1 (en) * | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2970286A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
| HRP20192183T1 (hr) | 2013-12-06 | 2020-02-21 | Vertex Pharmaceuticals Inc. | Spoj 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-karboksamida koristan kao inhibitor atr kinase, njegova priprava, različiti kruti oblici te njegovi radioaktivno označeni derivati |
| WO2015095337A2 (en) * | 2013-12-18 | 2015-06-25 | The Rockefeller University | PYRAZOLO[1,5-a]PYRIMIDINECARBOXAMIDE DERIVATIVES FOR TREATING COGNITIVE IMPAIRMENT |
| EA032488B1 (ru) | 2014-05-23 | 2019-06-28 | Ф. Хоффманн-Ля Рош Аг | Соединения 5-хлор-дифторметоксифенилпиразолопиримидина, представляющие собой ингибиторы янус-киназы |
| EP3152212B9 (en) | 2014-06-05 | 2020-05-27 | Vertex Pharmaceuticals Inc. | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
| EP3157566B1 (en) | 2014-06-17 | 2019-05-01 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of chk1 and atr inhibitors |
| IL252053B2 (en) | 2014-11-06 | 2024-04-01 | Lysosomal Therapeutics Inc | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2016073889A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| HK1258570A1 (zh) | 2015-09-30 | 2019-11-15 | Vertex Pharmaceuticals Inc. | 使用dna损伤剂及atr抑制剂的组合治疗癌症的方法 |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PH12018502124B1 (en) | 2016-04-04 | 2024-04-12 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| KR20180133461A (ko) | 2016-04-06 | 2018-12-14 | 리소소말 테라퓨틱스 인크. | 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물 및 의학적 장애의 치료에서의 그의 용도 |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11124516B2 (en) | 2016-04-06 | 2021-09-21 | BIAL-BioTech Investments, Inc. | Pyrrolo[1,2-A]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| MX389579B (es) | 2016-05-05 | 2025-03-20 | Bial R&D Invest S A | IMIDAZO[1,2-b]PIRIDAZINAS SUSTITUIDAS, IMIDAZO[1,5-b]PIRIDAZINAS SUSTITUIDAS, COMPUESTOS RELACIONADOS Y SU USO EN EL TRATAMIENTO DE TRASTORNOS MÉDICOS |
| PT3458456T (pt) | 2016-05-18 | 2020-12-07 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida |
| CN109963860A (zh) | 2016-09-19 | 2019-07-02 | 拜耳作物科学股份公司 | 吡唑并[1,5-a]吡啶衍生物及其作为农药的用途 |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| CR20190520A (es) | 2017-05-22 | 2020-01-21 | Hoffmann La Roche | Composiciones y compuestos terapéuticos y métodos para utilizarlos |
| CN108931633B (zh) * | 2018-05-22 | 2021-08-27 | 郑州大学第一附属医院 | 胆囊癌诊断和预后判断标志物pim1 |
| CN110294761B (zh) * | 2018-06-08 | 2020-09-08 | 南京雷正医药科技有限公司 | 作为Trk激酶抑制剂的取代的吡唑并[1,5-a]嘧啶化合物 |
| ES2938751T3 (es) | 2018-09-10 | 2023-04-14 | Lilly Co Eli | Derivados de pirazol[1,5-a]pirimidina-3-carboxamida útiles en el tratamiento de la psoriasis y el lupus eritematoso sistémico |
| MY210039A (en) | 2018-10-30 | 2025-08-22 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| TWI800696B (zh) | 2018-12-10 | 2023-05-01 | 美商美國禮來大藥廠 | 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺衍生物 |
| PH12022551623A1 (en) | 2020-01-13 | 2023-11-29 | Verge Analytics Inc | Substituted pyrazolo-pyrimidines and uses thereof |
| TWI810520B (zh) | 2020-02-12 | 2023-08-01 | 美商美國禮來大藥廠 | 7-(甲基胺基)吡唑并[1,5-a]嘧啶-3-甲醯胺化合物 |
| CA3167313A1 (en) | 2020-02-12 | 2021-08-19 | Thomas John Bleisch | Substituted 7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200301696B (en) | 2000-09-15 | 2004-04-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk. |
| AU2003299651A1 (en) * | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
-
2006
- 2006-10-04 TW TW095136893A patent/TW200745128A/zh unknown
- 2006-10-04 AR ARP060104367A patent/AR057979A1/es not_active Application Discontinuation
- 2006-10-04 CN CNA2006800443520A patent/CN101316847A/zh active Pending
- 2006-10-04 WO PCT/US2006/038805 patent/WO2007044407A2/en not_active Ceased
- 2006-10-04 CA CA002624500A patent/CA2624500A1/en not_active Abandoned
- 2006-10-04 JP JP2008534653A patent/JP5102212B2/ja not_active Expired - Fee Related
- 2006-10-04 US US11/542,902 patent/US7645762B2/en active Active
- 2006-10-04 EP EP06816216.3A patent/EP1931675B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5102212B2 (ja) | 2012-12-19 |
| EP1931675B1 (en) | 2015-01-14 |
| JP2009511478A (ja) | 2009-03-19 |
| EP1931675A2 (en) | 2008-06-18 |
| CN101316847A (zh) | 2008-12-03 |
| AR057979A1 (es) | 2008-01-09 |
| WO2007044407A3 (en) | 2007-06-14 |
| US7645762B2 (en) | 2010-01-12 |
| CA2624500A1 (en) | 2007-04-19 |
| US20070082902A1 (en) | 2007-04-12 |
| WO2007044407A2 (en) | 2007-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200745128A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| TW200745123A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| TW200745127A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| WO2007044449A3 (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| MY149044A (en) | Pyrazolopyrimidines - derivatives as cyclin dependent kinase inhibitors | |
| WO2007058942A3 (en) | Imidazopyrazines as protein kinase inhibitors | |
| MX2009011355A (es) | Nuevas pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas. | |
| WO2007044401A3 (en) | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| DE602006014848D1 (de) | Pyrazolopyrimidine als inhibitoren von cyclinabhän | |
| MX2009003733A (es) | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. | |
| WO2007058873A3 (en) | Imidazopyrazines as cyclin depentend kinase inhibitors | |
| MY139336A (en) | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| DK1537116T3 (da) | Pyrazolopyrimidiner egnede til behandling af cancersygdomme | |
| MY137888A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| MY134589A (en) | Imidazopyrazines as cyclin dependent kinase inhibitors | |
| MY137843A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| WO2008045267A3 (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| MX2009013729A (es) | Imidazopirazinas como inhibidores de proteina quinasa. | |
| WO2004026310A8 (en) | Novel imidazopyrazines as cyclin dependent kinase inhibitors | |
| MX2009003734A (es) | Pirazolopirimidinas como inhibidor de cinasas dependientes de ciclina. | |
| MY133311A (en) | Novel imidazopyridines as cyclin dependent kinase inhibitors | |
| WO2008057512A3 (en) | Imidazopyrazines as protein kinase inhibitors | |
| ZA200707342B (en) | Pyrrolopyrimidines useful as inhibitors of protein kinase | |
| WO2010088368A3 (en) | Imidazopyrazines as protein kinase inhibitors | |
| ZA200704476B (en) | Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases |