TW200641132A - Novel rumen bectria variants and process for preparing succinic acid employing the same - Google Patents
Novel rumen bectria variants and process for preparing succinic acid employing the sameInfo
- Publication number
- TW200641132A TW200641132A TW094116771A TW94116771A TW200641132A TW 200641132 A TW200641132 A TW 200641132A TW 094116771 A TW094116771 A TW 094116771A TW 94116771 A TW94116771 A TW 94116771A TW 200641132 A TW200641132 A TW 200641132A
- Authority
- TW
- Taiwan
- Prior art keywords
- gene
- succinic acid
- acid
- producing
- novel
- Prior art date
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to novel rumen bacterial mutants resulted from the disruption of a lactate dehydrogenase gene(ldhA) and a pyruvate formate-lyase gene(pfl)(which are involved in production of lactic acid, formic acid and acetic acid) from rumen bacteria; a novel bacterial mutant (Mannheimia succiniciproducens LPK7)having disruptions of a lactate dehydrogenase gene(ldhA), a pyruvate formate-lyase gene(pfl), a phosphotransacetylase gene(pta), and a acetate kinase gene(ackA); a novel bacterial mutant (Mannheimia succiniciproducens LPK4)havmg disruptions of a lactate dehydrogenase gene(ldhA), a pyruvate formate-lyase gene(pfl), and a phosphoenolpyruvate carboxylase gene(ppc), involved in the immobilization of CO2 in a metabolic pathway of producing succinic acid; and a method for producing succinic acid, which is characterized by the culture of the above mutants in anaerobic conditions. The inventive bacterial mutants have the property of producing succinic acid at high concentration while producing little or no organic acid, as compared to the prior wild-type strains of producing various organic acids. Thus, the inventive bacterial mutants are useful as strains for the industrial production of succinic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW94116771A TWI357929B (en) | 2005-05-23 | 2005-05-23 | Novel rumen bectria variants and process for prepa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW94116771A TWI357929B (en) | 2005-05-23 | 2005-05-23 | Novel rumen bectria variants and process for prepa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200641132A true TW200641132A (en) | 2006-12-01 |
| TWI357929B TWI357929B (en) | 2012-02-11 |
Family
ID=46728149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW94116771A TWI357929B (en) | 2005-05-23 | 2005-05-23 | Novel rumen bectria variants and process for prepa |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TWI357929B (en) |
-
2005
- 2005-05-23 TW TW94116771A patent/TWI357929B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI357929B (en) | 2012-02-11 |
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|---|---|---|---|
| MK4A | Expiration of patent term of an invention patent |