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TW200639160A - N-[(4, 5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application - Google Patents

N-[(4, 5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application

Info

Publication number
TW200639160A
TW200639160A TW095104263A TW95104263A TW200639160A TW 200639160 A TW200639160 A TW 200639160A TW 095104263 A TW095104263 A TW 095104263A TW 95104263 A TW95104263 A TW 95104263A TW 200639160 A TW200639160 A TW 200639160A
Authority
TW
Taiwan
Prior art keywords
methyl
thienyl
diphenyl
preparation
amine derivatives
Prior art date
Application number
TW095104263A
Other languages
English (en)
Inventor
Jean-Philippe Ducoux
Francis Barth
Murielle Rinaldi-Carmona
Christian Congy
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW200639160A publication Critical patent/TW200639160A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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TW095104263A 2005-02-09 2006-02-08 N-[(4, 5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application TW200639160A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0501366A FR2881744B1 (fr) 2005-02-09 2005-02-09 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TW200639160A true TW200639160A (en) 2006-11-16

Family

ID=34955350

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095104263A TW200639160A (en) 2005-02-09 2006-02-08 N-[(4, 5-diphenyl-2-thienyl)methyl]amine derivatives, their preparation and their therapeutic application

Country Status (16)

Country Link
US (2) US7687537B2 (zh)
EP (1) EP1858872A1 (zh)
JP (1) JP4823236B2 (zh)
KR (1) KR20070115941A (zh)
CN (1) CN101128451A (zh)
AR (1) AR052898A1 (zh)
AU (1) AU2006212162A1 (zh)
BR (1) BRPI0606942A2 (zh)
CA (1) CA2596613A1 (zh)
FR (1) FR2881744B1 (zh)
IL (1) IL185035A0 (zh)
MX (1) MX2007009439A (zh)
RU (1) RU2007133602A (zh)
TW (1) TW200639160A (zh)
UY (1) UY29366A1 (zh)
WO (1) WO2006084975A1 (zh)

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FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
CA2601709C (en) 2005-03-22 2017-02-14 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids
FR2894579B1 (fr) * 2005-12-12 2008-01-18 Sanofi Aventis Sa Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
WO2008034032A2 (en) * 2006-09-14 2008-03-20 Azevan Pharmaceuticals, Inc. Beta-lactam cannabinoid receptor modulators
FR2908766B1 (fr) * 2006-11-20 2009-01-09 Sanofi Aventis Sa Derives de pyrrole,leur preparation et leur utilisation en therapeutique.
EP1939181A1 (en) * 2006-12-27 2008-07-02 sanofi-aventis Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase
EP2196459B1 (en) * 2007-09-28 2016-11-02 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compound
WO2009041705A2 (en) * 2007-09-28 2009-04-02 Takeda Pharmaceutical Company Limited 5-membered heterocyclic compounds as proton pump inhibitors
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.
FR2943672B1 (fr) * 2009-03-27 2011-03-25 Sanofi Aventis Derives de 3-alcoxy-4,5-diarylthiophene-2-carboxamide,leur preparation et leur application en therapeutique.
US8609663B2 (en) 2009-11-18 2013-12-17 University Of Massachusetts Compounds for modulating TLR2
EP2587919B1 (en) 2010-07-01 2017-12-13 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
SG11201608064WA (en) 2014-03-28 2016-10-28 Azevan Pharmaceuticals Inc Compositions and methods for treating neurodegenerative diseases
US11628160B2 (en) 2017-09-15 2023-04-18 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury
JP2022538348A (ja) * 2019-06-28 2022-09-01 アールティーアイ インターナショナル Ｃｂ１アロステリック調節因子としての尿素誘導体

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EP0055471A1 (en) 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-alpha,alpha-bis(polyhalomethyl)-2-thiophenemethanamines
US4381311A (en) 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols
US4432974A (en) 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
GB9012936D0 (en) 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
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FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2860792B1 (fr) * 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.
FR2880023B1 (fr) * 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2880890B1 (fr) * 2005-01-19 2007-03-30 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique

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US20080009543A1 (en) 2008-01-10
US20100137402A1 (en) 2010-06-03
MX2007009439A (es) 2008-03-06
FR2881744A1 (fr) 2006-08-11
CN101128451A (zh) 2008-02-20
JP2008530060A (ja) 2008-08-07
RU2007133602A (ru) 2009-03-20
FR2881744B1 (fr) 2007-04-27
BRPI0606942A2 (pt) 2009-07-28
EP1858872A1 (fr) 2007-11-28
KR20070115941A (ko) 2007-12-06
AU2006212162A1 (en) 2006-08-17
JP4823236B2 (ja) 2011-11-24
CA2596613A1 (fr) 2006-08-17
UY29366A1 (es) 2006-10-02
WO2006084975A1 (fr) 2006-08-17
IL185035A0 (en) 2007-12-03
AR052898A1 (es) 2007-04-11
US7687537B2 (en) 2010-03-30

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