TW200628475A - PI3-kinases - Google Patents

PI3-kinases

Info

Publication number: TW200628475A
Authority: TW; Taiwan
Prior art keywords: inflammatory; diseases; allergic; inflammations; gastro
Prior art date: 2004-10-07

Application number

TW094134899A

Other languages

English (en)

Inventor

Steffen Breitfelder

Udo Maier

Trixi Brandl

Christoph Hoenke

Matthias Grauert

Alexander Pautsch

Matthias Hoffmann

Frank Kalkbrenner

Anne Joergensen

Gerhard Schaenzle

Stefan Peters

Frank Buettner

Eckhart Bauer

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-07

Filing date

2005-10-06

Publication date

2006-08-16

2004-10-07 Priority claimed from DE102004048877A external-priority patent/DE102004048877A1/de

2005-02-09 Priority claimed from DE102005005813A external-priority patent/DE102005005813A1/de

2005-10-06 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2006-08-16 Publication of TW200628475A publication Critical patent/TW200628475A/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/84—Naphthothiazoles

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

TW094134899A 2004-10-07 2005-10-06 PI3-kinases TW200628475A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102004048877A DE102004048877A1 (de)	2004-10-07	2004-10-07	PI3-Kinasen
DE102005005813A DE102005005813A1 (de)	2005-02-09	2005-02-09	PI3-Kinasen

Publications (1)

Publication Number	Publication Date
TW200628475A true TW200628475A (en)	2006-08-16

Family

ID=35583390

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW094134899A TW200628475A (en)	2004-10-07	2005-10-06	PI3-kinases

Country Status (14)

Country	Link
US (4)	US7691888B2 (zh)
EP (2)	EP2343303A1 (zh)
JP (1)	JP5122287B2 (zh)
KR (1)	KR20070064660A (zh)
CN (1)	CN101048418A (zh)
AR (1)	AR055273A1 (zh)
AU (1)	AU2005293607A1 (zh)
BR (1)	BRPI0516557A (zh)
CA (1)	CA2579279C (zh)
IL (1)	IL182398A0 (zh)
MX (1)	MX2007004051A (zh)
RU (2)	RU2007116861A (zh)
TW (1)	TW200628475A (zh)
WO (1)	WO2006040279A1 (zh)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050096332A1 (en) *	2003-10-30	2005-05-05	Boehringer Ingelheim International Gmbh	Use of tyrosine kinase inhibitors for the treatment of inflammatory processes
EP2343303A1 (de) *	2004-10-07	2011-07-13	Boehringer Ingelheim International GmbH	PI3-Kinase Inhibitoren
US20070238718A1 (en) *	2006-04-06	2007-10-11	Matthias Grauert	Thiazolyl-dihydro-indazole
US7517995B2 (en) *	2006-04-06	2009-04-14	Boehringer Ingelheim International Gmbh	Thiazolyl-dihydro-cyclopentapyrazole
US20070238746A1 (en) *	2006-04-06	2007-10-11	Trixi Brandl	Thiazolyl-dihydro-chinazoline
JP2009532425A (ja) *	2006-04-06	2009-09-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	チアゾリルジヒドロインダゾール
US7691868B2 (en) *	2006-04-06	2010-04-06	Boehringer Ingelheim International Gmbh	Thiazolyl-dihydro-quinazoline
US20070259855A1 (en) *	2006-04-06	2007-11-08	Udo Maier	Thiazolyl-dihydro-indazole
ATE405554T1 (de) *	2006-06-26	2008-09-15	Helm Ag	Verfahren zur herstellung von pramipexole
US7879887B2 (en) *	2006-06-29	2011-02-01	Nissan Chemical Industries, Ltd.	α-amino acid derivatives and medicaments containing the same as an active ingredient
US8779154B2 (en)	2006-09-26	2014-07-15	Qinglin Che	Fused ring compounds for inflammation and immune-related uses
GB0619611D0 (en) *	2006-10-04	2006-11-15	Ark Therapeutics Ltd	Compounds and their use
WO2009039140A1 (en) *	2007-09-17	2009-03-26	Smithkline Beecham Corporation	Pyridopyrimidine derivatives as pi3 kinase inhibitors
EP2240029A4 (en) *	2008-01-07	2012-08-22	Synta Pharmaceuticals Corp	COMPOUNDS FOR USE AGAINST INFLAMMATORY AND IMMUNOMIC DISEASES
UY31700A (es) *	2008-03-13	2009-11-10	Boehringer Ingelheim Int	Tiazolil-dihidro-indazoles
WO2009120826A1 (en) *	2008-03-27	2009-10-01	Wyeth	2-aryl- and 2-heteroarylthiazolyl compounds, methods for their preparation and use thereof
TWI443102B (zh) *	2008-03-31	2014-07-01	Genentech Inc	苯并哌喃及苯并氧呯ｐｉ３ｋ抑制劑化合物及其使用方法
CN102089303A (zh) *	2008-07-17	2011-06-08	旭化成制药株式会社	含氮杂环化合物
EP2327704A4 (en) *	2008-08-29	2012-05-09	Shionogi & Co	RING-CONDENSED AZOL DERIVATIVE WITH PI3K-INHIBITING EFFECT
EP2350084B1 (en)	2008-10-17	2015-06-24	Boehringer Ingelheim International GmbH	Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor
GB0900404D0 (en)	2009-01-12	2009-02-11	Addex Pharmaceuticals Sa	New compounds 4
US8278302B2 (en)	2009-04-08	2012-10-02	Boehringer Ingelheim International Gmbh	Substituted piperidines as CCR3 antagonists
JP5901020B2 (ja) *	2009-04-22	2016-04-06	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	癌の治療用ＰＩ３−キナーゼ阻害薬としてのチア−トリアザ−ａｓ−インダセン
US8288379B2 (en) *	2009-04-22	2012-10-16	Boehringer Ingelheim International Gmbh	Thia-triaza-cyclopentazulenes
WO2011000855A1 (en) *	2009-07-02	2011-01-06	Novartis Ag	2-carboxamide cycloamino ureas useful as pi3k inhibitors
PE20121148A1 (es) *	2009-08-17	2012-09-07	Intellikine Llc	Compuestos heterociclicos y usos de los mismos
EP2845592A1 (en)	2009-09-28	2015-03-11	F. Hoffmann-La Roche AG	Benzoxazepin PI3K inhibitor compounds and methods of use
RU2557658C2 (ru) *	2009-09-28	2015-07-27	Ф.Хоффманн-Ля Рош Аг	Бензоксепиновые ингибиторы pi3 и способы применения
ES2607952T3 (es)	2009-11-13	2017-04-04	Merck Serono S.A.	Derivados tricíclicos de Pirazol Amina
WO2011149937A1 (en)	2010-05-24	2011-12-01	Intellikine, Inc.	Heterocyclic compounds and uses thereof
US20130252944A1 (en) *	2010-07-14	2013-09-26	Christelle Bolea	Novel fused pyrazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
GB201011831D0 (en)	2010-07-14	2010-09-01	Addex Pharmaceuticals Sa	New compounds 5
TW201245176A (en)	2011-01-26	2012-11-16	Boehringer Ingelheim Int	New 5-alkynyl-pyridines
EP2546249A1 (en)	2011-07-15	2013-01-16	Boehringer Ingelheim International Gmbh	5-Alkynyl-pyridines
US8466162B2 (en)	2011-01-26	2013-06-18	Boehringer Ingelheim International Gmbh	5-alkynyl-pyridines
TWI592411B (zh)	2011-02-23	2017-07-21	英特爾立秦有限責任公司	激酶抑制劑之組合及其用途
JP5808826B2 (ja)	2011-02-23	2015-11-10	インテリカイン，エルエルシー	複素環化合物およびその使用
WO2012126901A1 (en)	2011-03-21	2012-09-27	F. Hoffmann-La Roche Ag	Benzoxazepin compounds selective for pi3k p110 delta and methods of use
BR112014018122A8 (pt) *	2012-02-06	2017-07-11	Glaxosmithkline Ip No 2 Ltd	Composto, uso de um composto, e, método para tratar tosse
WO2017156350A1 (en)	2016-03-09	2017-09-14	K-Gen, Inc.	Methods of cancer treatment
US12324807B2 (en)	2018-06-01	2025-06-10	Cornell University	Combination therapy for PI3K-associated disease or disorder
WO2020142559A1 (en)	2018-12-31	2020-07-09	Biomea Fusion, Llc	Inhibitors of menin-mll interaction
AU2019417833B2 (en)	2018-12-31	2024-11-07	Biomea Fusion, Inc.	Irreversible inhibitors of menin-MLL interaction
CA3228627A1 (en)	2021-08-11	2023-02-16	Thomas Butler	Covalent inhibitors of menin-mll interaction for diabetes mellitus
AU2022331496A1 (en)	2021-08-20	2024-02-29	Biomea Fusion, Inc.	Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer
WO2024155710A1 (en)	2023-01-18	2024-07-25	Biomea Fusion, Inc.	Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6- yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2-pyridinecarboxamide as a covalent inhibitor of menin-mll interaction

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2036026A (en)	1978-05-17	1980-06-25	Teijin Ltd	Hexahydronaphthoimidazothiazoles and process for preparing same
JPS5533405A (en)	1978-08-29	1980-03-08	Teijin Ltd	Hexahydronaphtho(1',2':4,5)imidazo(2,1-b)thiazole and its preparation
EP0186087B1 (de) *	1984-12-22	1989-08-23	Dr. Karl Thomae GmbH	Tetrahydro-benzthiazole, deren Herstellung und deren Verwendung als Zwischenprodukte oder als Arnzneimittel
US5358949A (en) *	1986-03-05	1994-10-25	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5182290A (en) *	1991-08-27	1993-01-26	Neurogen Corporation	Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
TW260664B (zh) *	1993-02-15	1995-10-21	Otsuka Pharma Factory Inc
JP3670309B2 (ja)	1993-04-01	2005-07-13	第一製薬株式会社	二環性複素環化合物
NO941135L (no)	1993-04-01	1994-10-03	Daiichi Seiyaku Co	Tiazolpyrimidin derivater
TW420669B (en) *	1994-03-28	2001-02-01	Nissan Chemical Ind Ltd	Pyridine type thiazolidines
AU727654B2 (en) *	1997-06-13	2000-12-21	Yamanouchi Pharmaceutical Co., Ltd.	Tricyclic pyrazole derivative
WO2001057008A1 (en) *	2000-02-07	2001-08-09	Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft	2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
IL151946A0 (en) *	2000-03-29	2003-04-10	Cyclacel Ltd	2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
US6608053B2 (en) *	2000-04-27	2003-08-19	Yamanouchi Pharmaceutical Co., Ltd.	Fused heteroaryl derivatives
KR100423899B1 (ko) *	2000-05-10	2004-03-24	주식회사 엘지생명과학	세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸
WO2003035618A2 (en)	2001-10-24	2003-05-01	Iconix Pharmaceuticals, Inc.	Modulators of phosphoinositide 3-kinase
AR038703A1 (es)	2002-02-28	2005-01-26	Novartis Ag	Derivados de 5-feniltiazol y uso como inhibidor de quinasa p i 3
EP1349179A1 (en) *	2002-03-18	2003-10-01	ATOFINA Research	Conductive polyolefins with good mechanical properties
CA2493843C (en)	2002-07-10	2012-04-17	Applied Research Systems Ars Holding N.V.	Azolidinone-vinyl fused-benzene derivatives
RU2326881C9 (ru)	2002-09-30	2009-04-10	Байер Фармасьютикалс Корпорейшн	Конденсированные производные азолпиримидина, обладающие свойствами ингибитора фосфатидилинозитол-3-киназы (pi3k)
BR0316386A (pt)	2002-12-06	2005-09-27	Warner Lambert Co	Benzoxazin-3-onas e seus derivados como inibidores de p13k
AU2003303231A1 (en)	2002-12-20	2004-07-14	Warner-Lambert Company Llc	Benzoxazines and derivatives thereof as inhibitors of pi3ks
GB0315966D0 (en) *	2003-07-08	2003-08-13	Cyclacel Ltd	Compounds
NO20041733L (no) *	2004-04-28	2005-10-31	Thin Film Electronics Asa	Organisk elektronisk krets med funksjonelt mellomsjikt og fremgangsmate til dens fremstilling.
EP2343303A1 (de) *	2004-10-07	2011-07-13	Boehringer Ingelheim International GmbH	PI3-Kinase Inhibitoren
FR2887993B1 (fr) *	2005-07-01	2007-08-03	Commissariat Energie Atomique	Dispositif de detection de rayonnements a electrodes empilees et methode de detection de rayonnements ionisants mettant en oeuvre un tel dispositif
US20070259855A1 (en) *	2006-04-06	2007-11-08	Udo Maier	Thiazolyl-dihydro-indazole
KR20090029182A (ko) *	2006-04-06	2009-03-20	베링거 인겔하임 인터내셔날 게엠베하	단백질 키나제 억제제로서 티아졸릴디하이드로인다졸 유도체

2005
- 2005-10-05 EP EP11158787A patent/EP2343303A1/de not_active Withdrawn
- 2005-10-05 JP JP2007535159A patent/JP5122287B2/ja not_active Expired - Lifetime
- 2005-10-05 MX MX2007004051A patent/MX2007004051A/es not_active Application Discontinuation
- 2005-10-05 CN CNA2005800344060A patent/CN101048418A/zh active Pending
- 2005-10-05 US US11/243,796 patent/US7691888B2/en not_active Expired - Lifetime
- 2005-10-05 RU RU2007116861/04A patent/RU2007116861A/ru not_active Application Discontinuation
- 2005-10-05 EP EP05805652A patent/EP1802636B1/de not_active Expired - Lifetime
- 2005-10-05 WO PCT/EP2005/055015 patent/WO2006040279A1/de not_active Ceased
- 2005-10-05 US US11/244,299 patent/US20060106013A1/en not_active Abandoned
- 2005-10-05 AU AU2005293607A patent/AU2005293607A1/en not_active Abandoned
- 2005-10-05 KR KR1020077010387A patent/KR20070064660A/ko not_active Withdrawn
- 2005-10-05 CA CA2579279A patent/CA2579279C/en not_active Expired - Lifetime
- 2005-10-05 BR BRPI0516557-1A patent/BRPI0516557A/pt not_active IP Right Cessation
- 2005-10-05 RU RU2007116858/04A patent/RU2403258C2/ru not_active IP Right Cessation
- 2005-10-06 TW TW094134899A patent/TW200628475A/zh unknown
- 2005-10-07 AR ARP050104225A patent/AR055273A1/es unknown
2007
- 2007-04-10 IL IL182398A patent/IL182398A0/en unknown
2009
- 2009-02-05 US US12/366,248 patent/US8232286B2/en active Active
2010
- 2010-01-11 US US12/685,213 patent/US8207349B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR20070064660A (ko)	2007-06-21
US20060100254A1 (en)	2006-05-11
US20060106013A1 (en)	2006-05-18
RU2007116858A (ru)	2008-12-27
JP5122287B2 (ja)	2013-01-16
BRPI0516557A (pt)	2008-09-09
AU2005293607A1 (en)	2006-04-20
US7691888B2 (en)	2010-04-06
AR055273A1 (es)	2007-08-15
US8207349B2 (en)	2012-06-26
RU2007116861A (ru)	2009-03-20
WO2006040279A1 (de)	2006-04-20
US20090156554A1 (en)	2009-06-18
US20100113414A1 (en)	2010-05-06
MX2007004051A (es)	2007-05-24
CA2579279A1 (en)	2006-04-20
EP1802636A1 (de)	2007-07-04
CA2579279C (en)	2013-10-01
EP2343303A1 (de)	2011-07-13
JP2008515852A (ja)	2008-05-15
IL182398A0 (en)	2007-07-24
US8232286B2 (en)	2012-07-31
EP1802636B1 (de)	2013-03-27
RU2403258C2 (ru)	2010-11-10
CN101048418A (zh)	2007-10-03

Publication	Publication Date	Title
TW200628475A (en)	2006-08-16	PI3-kinases
WO2007135026A3 (de)	2008-03-27	Substituierte pteridine als therapeutika
EA200702200A1 (ru)	2008-04-28	Дигидротиенопиримидины для лечения воспалительных заболеваний
ATE549338T1 (de)	2012-03-15	Substituierte pteridine, die mit einem viergliedrigen heterocyclus substituiert sind
WO2006058868A8 (de)	2007-01-18	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
WO2003096990A3 (en)	2004-02-26	Protein cages for the delivery of medical imaging and therapy
ZA200801511B (en)	2008-11-26	Novel diazaspiroalkanes and their use for treatment of CCR8 medicated diseases
HUS1500058I1 (hu)	2016-01-28	Benzoxazint tartalmazó gyógyszer-kombináció légúti betegségek kezelésére
MX2007004862A (es)	2007-05-09	Nuevos derivados de sulfonamida como moduladores del receptor de glucocorticoides para el tratamiento de enfermedades inflamatorias.
MX2009005279A (es)	2009-05-28	Derivados de n-(metil)-1h-pirazol-3-amina, n-(metil)-piridin-2-ami na y n-(metil)-tiazol-2-amina para el tratamiento de enfermedades asociadas con proteinas amiloides o tipo amiloide, tal como por ejemplo alzheimer.
WO2004074243A3 (en)	2004-12-02	Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
WO2008097924A3 (en)	2008-11-20	Pharmaceutical compositions comprising dextromethorphan analogs for the treatment of neurological disorders
WO2006058867A3 (de)	2006-10-26	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
PL2081910T3 (pl)	2012-07-31	Nowe związki
WO2007098106A3 (en)	2007-12-13	Respiratory tract delivery of interferon-tau
WO2008105507A1 (ja)	2008-09-04	脊髄損傷治療薬剤
WO2010135521A3 (en)	2011-05-05	Compositions and methods for the therapy and diagnosis of influenza
WO2006058869A3 (de)	2006-10-26	Substituierte pteridine zur behandlung von entzündlichen erkrankungen
PL1670482T5 (pl)	2022-10-03	Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego
MY142036A (en)	2010-08-16	New quaternized quinuclidine esters
MX2007004861A (es)	2007-05-09	Derivados de sulfonamida novedosos como moduladores de receptor glucocorticoide para el tratamiento de enfermedades inflamatorias.
WO2008043788A3 (en)	2008-06-05	Novel compounds
EP1696933A4 (en)	2007-06-20	COMPOSITIONS AND METHODS FOR ADMINISTERING TUBULIN BINDING AGENTS FOR THE TREATMENT OF OCULAR DISORDERS
NO20054180D0 (no)	2005-09-08	Behandling av bakterielle sykdommer i andedrettsorganene ved lokal tilforsel av fluorkinoloner
MX2007006357A (es)	2007-06-20	Pteridinas sustituidas para el tratamiento de enfermedades inflamatorias.