TW200612922A - Inhibitors of hsp90 - Google Patents
Inhibitors of hsp90Info
- Publication number
- TW200612922A TW200612922A TW094125263A TW94125263A TW200612922A TW 200612922 A TW200612922 A TW 200612922A TW 094125263 A TW094125263 A TW 094125263A TW 94125263 A TW94125263 A TW 94125263A TW 200612922 A TW200612922 A TW 200612922A
- Authority
- TW
- Taiwan
- Prior art keywords
- hsp90
- inhibitors
- compounds
- benzoimidazolone
- treatment
- Prior art date
Links
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 title 1
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 title 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- MYONAGGJKCJOBT-UHFFFAOYSA-N benzimidazol-2-one Chemical class C1=CC=CC2=NC(=O)N=C21 MYONAGGJKCJOBT-UHFFFAOYSA-N 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59133004P | 2004-07-27 | 2004-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200612922A true TW200612922A (en) | 2006-05-01 |
Family
ID=35058768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094125263A TW200612922A (en) | 2004-07-27 | 2005-07-26 | Inhibitors of hsp90 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090069341A1 (zh) |
| EP (1) | EP1776110A1 (zh) |
| JP (1) | JP2008508217A (zh) |
| KR (1) | KR20070045290A (zh) |
| CN (1) | CN101027054A (zh) |
| AR (1) | AR050084A1 (zh) |
| AU (1) | AU2005266493B2 (zh) |
| BR (1) | BRPI0513857A (zh) |
| CA (1) | CA2574139A1 (zh) |
| MX (1) | MX2007001131A (zh) |
| PE (1) | PE20060572A1 (zh) |
| RU (1) | RU2007106933A (zh) |
| TW (1) | TW200612922A (zh) |
| WO (1) | WO2006010594A1 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005063222A1 (ja) * | 2003-12-26 | 2005-07-14 | Kyowa Hakko Kogyo Co., Ltd. | Hsp90ファミリー蛋白質阻害剤 |
| AU2006236557A1 (en) * | 2005-04-14 | 2006-10-26 | Novartis Vaccines And Diagnostics Inc. | 2-amino-quinazolin-5-ones as HSP90 inhibitors useful in treating proliferation diseases |
| US20080200488A1 (en) * | 2005-08-11 | 2008-08-21 | Manley Paul W | Combinations Comprising a Protein Kinase Inhibitor Being a Pyrimidylaminobenzamide Compound and a Hsp90 Inhibitor Such as 17-Aag |
| SI1934174T1 (sl) | 2005-10-07 | 2011-08-31 | Exelixis Inc | Inhibitorji MEK in postopki za njihovo uporabo |
| WO2007092496A2 (en) * | 2006-02-07 | 2007-08-16 | Conforma Therapeutics Corporation | 7,9-dihydro-purin-8-one and related analogs as hsp90-inhibitors |
| WO2008024963A1 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Benzene, pyridine, and pyridazine derivatives |
| FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
| TR201900306T4 (tr) | 2006-12-14 | 2019-02-21 | Exelixis Inc | Mek inhibitörlerini kullanma yöntemleri. |
| ES2441196T3 (es) * | 2007-04-18 | 2014-02-03 | Kissei Pharmaceutical Co., Ltd. | Derivado de anillo condensado nitrogenado, composiciones farmacéuticas que lo contienen, y su uso con fines médicos |
| US7932279B2 (en) | 2007-10-12 | 2011-04-26 | Arqule, Inc. | Substituted tetrazole compounds and uses thereof |
| AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| CN102786512A (zh) * | 2012-05-31 | 2012-11-21 | 中国人民解放军军事医学科学院毒物药物研究所 | N-芳基不饱和稠环叔胺类化合物及其制备方法和抗肿瘤应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ239540A (en) * | 1990-09-24 | 1993-11-25 | Neurosearch As | 1-phenyl benzimidazole derivatives and medicaments |
| US5621007A (en) * | 1993-11-03 | 1997-04-15 | Bristol-Myers Squibb Company | Method for regulation of transmembrane chloride conductance |
| US7211561B2 (en) * | 2001-10-12 | 2007-05-01 | Cedars-Sinai Medical Center | Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa) |
| US20050089473A1 (en) * | 2003-09-10 | 2005-04-28 | Cedars-Sinai Medical Center | Potassium channel mediated delivery of agents through the blood-brain barrier |
-
2005
- 2005-07-25 AR ARP050103071A patent/AR050084A1/es not_active Application Discontinuation
- 2005-07-25 PE PE2005000865A patent/PE20060572A1/es not_active Application Discontinuation
- 2005-07-26 US US11/658,365 patent/US20090069341A1/en not_active Abandoned
- 2005-07-26 WO PCT/EP2005/008118 patent/WO2006010594A1/en not_active Ceased
- 2005-07-26 RU RU2007106933/04A patent/RU2007106933A/ru unknown
- 2005-07-26 AU AU2005266493A patent/AU2005266493B2/en not_active Ceased
- 2005-07-26 BR BRPI0513857-4A patent/BRPI0513857A/pt not_active IP Right Cessation
- 2005-07-26 CN CNA2005800323187A patent/CN101027054A/zh active Pending
- 2005-07-26 MX MX2007001131A patent/MX2007001131A/es active IP Right Grant
- 2005-07-26 CA CA002574139A patent/CA2574139A1/en not_active Abandoned
- 2005-07-26 EP EP05775880A patent/EP1776110A1/en not_active Withdrawn
- 2005-07-26 JP JP2007523003A patent/JP2008508217A/ja not_active Withdrawn
- 2005-07-26 TW TW094125263A patent/TW200612922A/zh unknown
- 2005-07-26 KR KR1020077004505A patent/KR20070045290A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006010594A1 (en) | 2006-02-02 |
| RU2007106933A (ru) | 2008-09-10 |
| CN101027054A (zh) | 2007-08-29 |
| AR050084A1 (es) | 2006-09-27 |
| JP2008508217A (ja) | 2008-03-21 |
| AU2005266493B2 (en) | 2009-09-10 |
| MX2007001131A (es) | 2007-03-15 |
| KR20070045290A (ko) | 2007-05-02 |
| PE20060572A1 (es) | 2006-06-27 |
| AU2005266493A1 (en) | 2006-02-02 |
| US20090069341A1 (en) | 2009-03-12 |
| CA2574139A1 (en) | 2006-02-02 |
| EP1776110A1 (en) | 2007-04-25 |
| BRPI0513857A (pt) | 2008-05-20 |
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