TW200511994A - Novel compounds and therapeutic uses thereof - Google Patents
Novel compounds and therapeutic uses thereofInfo
- Publication number
- TW200511994A TW200511994A TW092127020A TW92127020A TW200511994A TW 200511994 A TW200511994 A TW 200511994A TW 092127020 A TW092127020 A TW 092127020A TW 92127020 A TW92127020 A TW 92127020A TW 200511994 A TW200511994 A TW 200511994A
- Authority
- TW
- Taiwan
- Prior art keywords
- compounds
- discloses
- pharmaceutically acceptable
- useful
- novel compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 230000001225 therapeutic effect Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002000 scavenging effect Effects 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pyridine Compounds (AREA)
Abstract
The invention discloses a novel series of compound represented by general formula (I), its derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts , solvates wherein X, n,k,z, R1, R2, R3, R4, R5 and R6 are as defined in the specification that are useful in (i) normalizing elevated blood glucose levels in diabetes, (ii) treating disorders related to glucose intolerance and (iii) for scavenging free radicals of mammals. The invention also discloses pharmaceutically acceptable composition comprising these compounds, method for preparation of the compounds as defined above and method of treating mammals including human beings by administering an effective amount of said compounds to a subject in need thereof. The invention further discloses use of these compounds in the manufacture of a medicament useful for treatment of different disease conditions as stated above.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37032402P | 2002-04-08 | 2002-04-08 | |
| PCT/IB2003/001330 WO2003084940A1 (en) | 2002-04-08 | 2003-04-03 | Thiazolidine-4-carbonitriles and analogues and their use as dipeptidyl-peptidas inhibitors |
| US10/408,276 US7138416B2 (en) | 2002-04-08 | 2003-04-08 | Compounds and therapeutic uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200511994A true TW200511994A (en) | 2005-04-01 |
Family
ID=57798578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092127020A TW200511994A (en) | 2002-04-08 | 2003-09-30 | Novel compounds and therapeutic uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW200511994A (en) |
-
2003
- 2003-09-30 TW TW092127020A patent/TW200511994A/en unknown
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