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TW200508609A - Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays - Google Patents

Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays

Info

Publication number
TW200508609A
TW200508609A TW093120755A TW93120755A TW200508609A TW 200508609 A TW200508609 A TW 200508609A TW 093120755 A TW093120755 A TW 093120755A TW 93120755 A TW93120755 A TW 93120755A TW 200508609 A TW200508609 A TW 200508609A
Authority
TW
Taiwan
Prior art keywords
cell membrane
detection
membrane
antigens
associated proteins
Prior art date
Application number
TW093120755A
Other languages
Chinese (zh)
Inventor
Jia Cheng Yang
En-Qing Tan
Michael Seul
Original Assignee
Bioarray Solutions Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioarray Solutions Ltd filed Critical Bioarray Solutions Ltd
Publication of TW200508609A publication Critical patent/TW200508609A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/971—Capture of complex after antigen-antibody reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Disclosed are methods relating to cell membrane fragments associated with microbeads, so that the characteristics of the cells the fragments originated from can be determined. The fragments can be oriented with what was the outer surface of the cell membrane facing outwardly, so that the antigens associated with the membrane can be contacted with ligands (including antibodies) to antigens in the membranes which would be accessible to antibodies in vivo. The system is useful, inter alia, for detection of panel reactive antibodies in donor serum, as well as detection of other cell membrane antigens; or quantitation of particular cell membrane antigens.
TW093120755A 2003-07-15 2004-07-12 Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays TW200508609A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48745203P 2003-07-15 2003-07-15

Publications (1)

Publication Number Publication Date
TW200508609A true TW200508609A (en) 2005-03-01

Family

ID=34079372

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093120755A TW200508609A (en) 2003-07-15 2004-07-12 Detection of cell membrane-associated proteins using membrane fragments displayed on encoded microparticle arrays

Country Status (4)

Country Link
US (1) US7332349B2 (en)
CA (1) CA2574109C (en)
TW (1) TW200508609A (en)
WO (1) WO2005006960A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2917174B1 (en) * 2007-06-08 2021-02-12 Bio Rad Pasteur MULTIPLE ANALYSIS OF BLOOD SAMPLES
WO2009006312A1 (en) * 2007-07-03 2009-01-08 One Lambda Methods of detecting antibodies specific for denatured hla antigens
US8628932B2 (en) 2007-07-03 2014-01-14 One Lambda Methods of detecting antibodies specific for denatured HLA antigens
US8394594B2 (en) * 2007-09-11 2013-03-12 Kode Biotech Limited Peptide-lipid constructs and their use in diagnostic and therapeutic applications
WO2009117370A1 (en) * 2008-03-16 2009-09-24 Synamem Corporation Membrane-coated particles
ES2569380T3 (en) 2008-06-30 2016-05-10 Institut National De La Sante Et De La Recherche Medicale Disseminated CD31 detection, diagnosis of atherothrombosis and autoimmune disorders, and procedures to analyze signaling pathways
CN105866426B (en) 2008-12-01 2018-11-23 小利兰·斯坦福大学托管委员会 For detecting the method and composition of complement-binding antibody
GB0913258D0 (en) 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
US20120178081A1 (en) * 2010-12-31 2012-07-12 Affymetrix. Inc. Methods of Labeling Cells, Labeled Cells, and uses Thereof
WO2013154709A1 (en) 2012-04-13 2013-10-17 Diabetomics, Llc Maternal biomarkers for gestational diabetes
US10101337B2 (en) * 2013-03-14 2018-10-16 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting donor-specific antibodies and systems for practicing the same
US10527613B2 (en) 2015-11-10 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Biomarker detection methods and systems and kits for practicing same
WO2021002650A1 (en) * 2019-06-30 2021-01-07 주식회사 알틱스 Cross-matching image processing method and apparatus based on deep learning
WO2021168135A1 (en) * 2020-02-18 2021-08-26 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for inducing immune tolerance in transplantation recipients

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251691B1 (en) * 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
US5948627A (en) * 1997-05-30 1999-09-07 One Lambda Immunobead flow cytometric detection of anti-HLA panel-reactive antibody

Also Published As

Publication number Publication date
CA2574109C (en) 2012-11-13
WO2005006960A2 (en) 2005-01-27
US20050059095A1 (en) 2005-03-17
US7332349B2 (en) 2008-02-19
CA2574109A1 (en) 2005-01-27
WO2005006960A3 (en) 2005-06-30

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