TW200427414A - Method for producing nutritional product containing L-Arginine - Google Patents

Abstract

A method for producing a nutritional product containing L-Arginine comprises: (a) arbitrarily mixing L-Arginine with at least one ingredient selected from the group consisting of acid-flavaoring agents, sweeteners, coloring material, fillers, flavors, and lubricants, and all or a portion of the nutritional supplements other than L-Arginine in the production of the invented product in the presence of ethanol, and performing a wet granulation process; (b) drying the obtained wet granules;(c) selectively processing the dried granules obtained from Step (b); and (d) adding the rest of the ingredients when the ingredients added in Step (a) are only a portion of the whole ingredients.

Description

200427414 (1) 发明. Description of the invention [Technical field to which the invention belongs] The present invention relates to a method for manufacturing a nutritional supplement product containing L-spermine acid, in particular to the production of L-spermine containing ethanol by wet granulation method using ethanol Method of acid nutrition supplement products. [Background of the Invention] L-Arginine is an amine acid required by the human condition. Scientists first isolated pure L-arginine from animal rhino horns at the end of the nineteenth century, and later discovered that L -Arginine is the sole source of creatinine in the body, and sarcosine is a substance necessary for ATP regeneration. L-arginine can also increase the release of blood glucose hormones and insulin, and mediate abnormal blood glucose. In addition, L-arginine has been successfully used to improve male sperm production and treat metabolic alkalosis. Three scientists, including Ferid Murad, Robert F. Furchgott, and Louis JL Ignarro, discovered that nitric oxide (NO) is an important substance that transmits signals everywhere in the human body. 8 years won the Nobel Prize in Biomedical Sciences. NO is a physiological gas that is produced by cells and penetrates cell membranes to regulate cell functions. L-arginine is a nitrogen-rich amino acid, which has twice the nitrogen content of other amino acids. It is a very important NO physiological precursor. L-spermine acid is catalyzed by NO synthetase. NO, NO represents the relaxation factor of the inner wall of blood vessels, which regulates the diastolic elasticity of the entire cardiovascular system to ensure adequate supply of oxygen throughout the body, and at the same time adjusts the function of the vascular endothelium to prevent lipids and blood -4-(2) (2) 200427414 Plate, white blood cells and other adhesions to keep blood flow in the blood vessel lumen unobstructed. L-Arginine can be found in foods with high protein content. Generally, healthy people can make enough L-Arginine daily. However, in some cases, it must be supplied in additional ways to maintain the normal body. Features. [Previous technology] The present invention relates to a method for manufacturing a nutritional supplement product containing L-arginine. The main component of the nutritional supplement product is L-arginine. Other condiments can be acidulants, sweeteners, spices, Pigments and / or lubricants. Existing L-arginine-based powdered nutritional supplement products are manufactured by mixing powder directly or wet granulating with water or aqueous solution. However, both of these manufacturing methods have their own advantages. Weaknesses or difficulties. The method of direct powder mixing is to directly mix the ingredients, but to use this method, each ingredient powder must meet a number of height requirements, including: Each ingredient powder must be uniform in size, then the uniformity of the ingredients will be good after mixing; The density of the powder is high, so that the product will not be fluffy after being mixed, and will not fly when filled; if the powder has good fluidity, the bagging speed will be fast. However, it is difficult for each component powder to fully meet these requirements. Therefore, it has been manufactured by wet granulation, that is, by adding liquid and wet granules. In addition, when the powder is directly mixed, there is also a problem in filling and packaging. The reason is that the nutritional supplement product is hygroscopic. Taking aluminum foil packaging as an example, when the powder mixture of various ingredients is filled with powder, There is a flying phenomenon. After flying, some powder will stick to the edge of the aluminum foil bag, making the sealing bag unable to be tightly sealed, and the phenomenon of moisture absorption and agglomeration during storage. To -5- (3) (3) 200427414 When using wet granulation with water or aqueous solution to manufacture the product, the product composition is highly hygroscopic and the product has high viscosity after moisture absorption. Due to the high viscosity in the wet granulation process, it is difficult to carry out the process smoothly. [Summary of the Invention] In order to solve the above-mentioned problems, the inventors found after research that when granulating with ethanol or an ethanol solution to produce the nutritional supplement product, the granulation process is extremely smooth, eliminating the need to directly mix the powder The manufacturing method is related to the various characteristic requirements and disadvantages of each component powder, and it also improves the problem of high viscosity that affects operation when wet granulation is performed with water or aqueous solution. Therefore, the present invention provides a method for manufacturing a nutritional supplement product containing L-arginine, comprising: (a) L-arginine, at least one selected from the group consisting of an acidulant, a sweetener, a pigment, and a tincture , Spices and lubricants, and supplementary substances other than L-arginine, which are used selectively, all or part of all ingredients used in the manufacture of this product are mixed with ethanol in any order and wet-processed Granules; (b) drying the obtained wet granules; (c) selectively granulating the dried granules of step (b); and (d) when the ingredients involved in the mixing in step (a) are used to manufacture the product For all ingredients, add the remaining ingredients and mix. In addition to eliminating the problem of direct mixing of dry powder and improving the disadvantages of high viscosity and difficult to operate, the method of the present invention also gives a number of advantages-6- (4) (4) 200427414 points, for example: there will be no The phenomenon of dough formation by water wet granulation method occurs, shorter drying time, lower drying temperature, product is not easy to agglomerate, uniform particles, small total surface area (that is, larger particles), pigments are evenly distributed on the particles, so the acceptance High product flowability, easy filling and packaging, fast dissolving speed after entering the water, etc. In addition, the use of ethanol has an additional bactericidal effect during the manufacturing process. [Embodiment] The nutritional supplement product of the present invention is mainly composed of L-arginine, and its amount is not particularly limited, and may be about 30 to about 80% by weight based on the total amount of the product ingredients. The nutritional supplement product of the present invention is a mixture of granules, which can be used after being added to water before use. Since L-arginine is an amino acid with a fishy smell, it will leave an unpleasant feeling when the L-arginine solution is used alone. Therefore, products without added flavoring agents are not easily accepted by consumers. It can be used for flavoring substances such as sour, sweetener, and flavor. The sour agent used in the present invention may be one commonly used in the food or pharmaceutical industry, such as citric acid, malic acid, etc., and the amount thereof is not particularly limited so as to be able to produce a sour taste suitable for mouthfeel, but a sufficient amount of the sour agent can be removed The unpleasant fishy smell of the aforementioned amino acid. The use of sweeteners can further increase consumer acceptance. The sweeteners used in the present invention can be those commonly used in the food or pharmaceutical industry, such as aspartame, Acesulfame K 'glycyrrhizine, stevia extract. (Stevia), sucrose, etc. It can be used in an amount of (5) 200427414 to produce a sweetness suitable for mouthfeel. The flavor used in the present invention may be a food or pharmaceutical such as a fruit flavor. The pigment used in the present invention can be food or pharmaceutical. The choice of color can be used with spices, for example, using orange pigment. The ingredients used in the products of the present invention may also include those commonly used in the pharmaceutical or pharmaceutical industries, such as silicon dioxide, titanium, and the like. The ingredients used in the product of the present invention may also contain tincture or those commonly used in the pharmaceutical industry, such as (lactose), mannito: (polyethylene glycol), etc. Some consumers consume the acidity of the j agent, which can be reduced at this time. The sour agent is used, and the ingredients used in the product of the present invention may also include L-nutritional supplement products, such as sugarcane (lycoopene), red croaker, cyanobacteria, wheat seed powder, etc. The sour agent, sweetness used in this case There is no particular limitation on the amount of each adjuvant such as agents, pigments, fillers, etc. Those skilled in the art can judge, if necessary, to adjust the present invention for producing camps containing L-arginine, including the following steps: (a) L -Arginine, at least one selected from the group consisting of acids, tinctures, flavors and lubricants, such as those commonly used in industry. For orange flavor, a slip agent can be used, which can be food magnesium stearate. , Dioxide filling, which can be food: Xylitol), lactose 1), polyethylene glycol 萏 may not like sour taste to replace with 塡 filling. Other alcohols than arginine), lycopene flavor, lubricant , 塡 dosage is food or Method for medicinal supplement product flavoring agent, sweetener, color condiment, and selective supplements other than L-arginine used in the production of -8-(6) (6) 200427414, etc. are used to manufacture the product All or part of all ingredients are mixed with ethanol in any order and wet granulated; (b) the obtained wet granules are dried; (c) the dried granules of step (b) are optionally granulated; and (d) When the ingredients involved in step (a) are part of all ingredients used to make the product, add the remaining ingredients and mix. The order of adding the ingredients in the method of the present invention is not particularly limited, but it is better to add the lubricant and perfume after drying and granulating, because the lubricant is a particulate medium, which buffers between the particles and reduces the Friction and increase the fluidity of the particles to facilitate filling. As for the fragrance, it is generally volatile. In order to prevent it from being volatilized during the drying or granulation process, it should be added after the drying and granulation steps. In addition, in order to allow the ethanol to be evenly distributed on the component particles, the timing of the addition of ethanol should be after mixing L-spermine, sour, sweetener, pigment, tincture; or, after L-sperine, sour After the agent, sweetener and tincture are mixed, an ethanol solution formed by dissolving the pigment in ethanol is added to the mixture. The ingredients can be honed and sieved before they are mixed. In step (a), the amount of ethanol used is about 3 to about 30 parts by weight, and preferably about 6 to about 15 parts by weight, based on 100 parts by weight of the total amount of ingredients used. The ethanol used can be added all at once or in several times; ethanol can be added separately or after dissolving the pigment. Mixing and making of step (a) (7) (7) 200427414 The granulation process can be performed using conventional equipment, such as Supermixer or other similar equipment. The wet granulation process can be performed at a temperature ranging from about 45 to about 75 ° C. The drying process of step (b) can be performed using conventional drying equipment, such as a tray dryer or a fluid bed drier y e r. The temperature and drying time used during drying depend on the batch size produced and the drying equipment, and its temperature range may be about 50 to about 75-t, and preferably about 55 to 60 ° C. The end point of drying depends on the content of residual ethanol after drying. The content of residual ethanol in the product should preferably be less than about 1.5% of the weight of the product, and more preferably less than about 1.0%. After the drying step (b), the dried granules are sieved and granulated (c). The granulation process can be performed using conventional equipment, such as FitzmUl equipment or similar equipment, and then packaged. The packaging material is impervious. Humidity is the original shellfish []. The method of the present invention should be carried out at a relative humidity of about 40% to about 60%, and the packaging process should also be carried out at this relative humidity. When consumers use the products of the present invention, they only need to Tear open the package, pour the contents into water and stir well before use. The method, advantages and effects of the present invention can be more clearly understood through the following examples, but the examples are provided for the purpose of example only. Explain how to implement the invention, but not to limit the scope of the invention. Example 1 Malic acid, citric acid, aspartame, Acesulfame K and -10- (8) 200427414

Ingredients such as Sunset Yellow are added to the Supermixer in the amounts listed in Table 1 and mixed first, and then L-Arginine is added to the Supermixer and mixed. After ethanol (90 g) was added to the obtained mixture, wet granulation was performed. The wet granules produced by the wet granulation are dried in a 6 ° C oven for 2 hours, and the whole granules are passed through a No. 20 sieve in a Fitzmill. Then add Cab-0-Sil and orange flavor, and then use V-blender After mixing, they are packaged. Table 1 Ingredient Function Weight Percent 1kg Batch L-Arginine Main Ingredients 6 4.94% 0.6494 kg Malic Acid Sour Agent 2 6.00% 0.2600 kg Citric Acid Sour Agent 6.50% 0.0650 kg Aspartame Sweetness Agent 0.60% 0.0060 kg Acesulfame K sweetener 0.40% 0.0 0 4 0 kg Sunset Yellow pigment 0.06% 0.0006 kg orange flavor spices 0.60% 0.0 0 6 0 kg Cab-O-Sil lubricant 0.90% 0.0090 kg

Comparative Example 1 Malic acid, citric acid, aspartame and Acesulfame K were added to the Supermixer in the amounts listed in Table 1 and mixed first, and then L-arginine was added to the Supermixer and mixed. After the pigment Sunset Yellow was dissolved in water (30 g), the pigment aqueous solution was added to the mixture, followed by wet granulation. The resulting wet granules are dried in an oven at 60 ° C for 3 hours, and granulated through a No. 20 sieve through Fitzmiii, then added -11-200427414 〇)

Cab-0-Sil and orange flavor are mixed with V-blender and packaged. The manufacturing process and products of Example 1 and Comparative Example 1 are compared below, as shown in Table A below.

Table A Properties) Granulation method Water granulation method Ethanol granulation process is difficult. The granulation process is difficult. The CiSL m process is convenient for every 1 gram of granulation, and the batch size of 1 kilogram can be (only) 30 batches. About two grams of water are used for granulation and the amount of water is 90 grams. During the granulation process, extremely small grams of ethanol are used for granulation. The viscosity affects the smooth granulation process of the granulator. The pigment moves 5 and in such a small amount. The water is evenly distributed5 Because the ingredients are used to make the pineapple 5 unable to wet the solubility of all powders in ethanol5, the color limit after granulation will not cause the dough to form and it is difficult to distribute uniformly. After the addition of the phenomenon caused by an excessive amount of water, under the influence of rising temperature, the whole mixture will form a dough, making granulation impossible. Dry CJ3, the boiling point of water is loot: the boiling point of ethanol is 780 ° C, the process is more difficult, the drying time is easier than the volatility, and the drying time is longer. Shorter 〇12- (10) 200427414 When high, the product is prone to agglomeration when stored. The affinity of the ingredients for ethanol is not high, and in the case of residual ethanol, the product is not easy to agglomerate. Sterilization There is no additional bactericidal effect during the granulation process. Due to the ethanol treatment, there is an additional bactericidal effect during the granulation process.

Example 2

Add malic acid, citric acid, xylitol, aspartame, Acesulfame K, and pigment Erythrosine Aluminum Lake to the Supermixer in the amounts listed in Table 2 below, mix them first, and then add L-Arginine to the S upermi X er mixed. After adding ethanol (90 g) to the obtained mixture, wet granulation was performed. The wet granules produced by the wet granulation are dried in an oven at 60 ° C for 2 hours, and the whole granules are passed through a No. 20 sieve in a Fitzmill. Then, Cab-0-Sil and strawberry flavor are added, and then V- The blender is mixed and packaged. -13- (11) 200427414 Table 2 Ingredient Function Weight Percent 1kg Bulk L-Arginine Main Ingredients 6 4.94% 0.6494 kg Malate Sour Flavor 13.00% 0. 1 3 00 kg Citric Sour Flavor 3.25% 0.0325 kg Xylose Alcohol tincture 16.07% 0.11 607 kg Aspartame sweetener 0.60% 0.0060 kg Acesulfame K sweetener 0.40% (K0040 kg Erythrosine pigment 0.04% 0.0004 kg Aluminum Lake Strawberry flavor spices 0.80% 0.0080 kg Cab- O-Sil lubricant 0.90% 0.0090 kg

Example 3

Add malic acid, citric acid, xylitol, aspartame, Acesulfame K, and the pigment Tartarine Aluminum Lake to the Supermixer in the amount shown in Table 3 below, mix them first, and then add L-Arginine to the S upermi X er mixed. After adding ethanol (90 g) to the obtained mixture, wet granulation was performed. The wet granules produced by the wet granulation are dried in an oven at 60 ° C for 2 hours, and the whole granules are passed through a No. 20 sieve in a Fit zmill. Then, Cab-0-Sil and mango flavor are added, and then V- blender * Blends and wraps. -14- (12) 200427414 Table 3 Ingredient function ----- g 鼍 percentage 1 kg batch L-arginine main ingredient ^ 4.94% 0.6494 kg malic acid sour agent 1 3-00% 0.1 3 00 kg lemon Tartrazine 3.25% 0.0325 kg Xylitol tincture 16.06% 0. 1 606 kg Aspartame 0.60% 0.0060 kg Acesulfame K Sweetener 0 4 0% 0.0040 kg T artrazine Pigment 0.05% 0.0005 kg Aluminum Lake Mango Flavor Spice 0.8% 0.0080 kg Cab-O-Sil Lubricant 0.90% 0.0090 kg Example 4 After citric acid was honed and passed through a No. 60 sieve (particle size 250 μm), the L-arginine, malic acid, milled citric acid, aspartame, and Acesulfame are added to gluten to mix as shown in Table 4 below. Dissolve Sunset Y 11 〇w in ethanol. Then add the ethanol solution of Sunset Yellow to the mixture in the container slowly during the stirring process. During the stirring process, add two to three times of ethanol to the mixture. The resulting mixture (total amount of ethanol used was 90 g) was subjected to wet granulation. The resulting mixed wet granules were placed in a dry box at 60 ° C. The ethanol was removed at a drying temperature of 0 °, and the dried particles after the ethanol removal were sieved. The sieved dry granules are poured into V-blender, and then orange flavor is added separately with Cab_〇_sn-15-(13) (13) 200427414 and packaged. Table 4 Ingredient Function Weight Percent 1kg Batch L-Arginine Main Ingredients 6 4.94% 0.6494 kg Malic Acid Sour Flavor 2 6.00% 0.2600 kg Citric Acid Sour Flavor 6.50% 0.0650 kg Aspartame Sweet Sweetener 0.60% 0.0060 kg Acesulfame K Sweetener 0.40% 0.0040 kg Sunset Yellow Pigment 0.06% 0.0006 kg Orange Flavor Spice 0.60% 0.0060 kg Cab-O-Sil Lubricant 0.90% 0.0090 kg

Claims (1)

(1) (1) 200427414 Scope of patent application ^ w 1. A method for manufacturing a nutritional supplement product containing L-arginine, comprising: (a) selecting L-arginine, at least one kind of acidity Additives, sweeteners, pigments, tinctures, flavors and lubricants, and optional supplements other than L-arginine, all or part of all ingredients used in the manufacture of products Mixed with ethanol in any order and wet granulated; (b) drying the obtained wet granules; (c) optionally granulating the dried granules of step (b); and (d) when step (a When the ingredients involved in mixing are used to make all the ingredients of the product, the remaining ingredients are added and mixed. 2. The method according to item 1 of the scope of patent application, comprising: (a 1) mixing L-arginine, sour agent, sweetener, coloring agent and optionally used fillers; ® (a2) in step (A 1) wet granulation after adding ethanol to the obtained mixture; (b) drying the obtained wet granules; < (c) granulating the dried granules of step (b); and (d) granulating Flavors and / or lubricants are added to the previously sized granules and mixed. 3. The method according to item 1 of the patent application scope, including: (a 1) L-arginine, sour agent, sweetener, and selective use of -17- (2) (2) 200427414 tincture filler Mixing; (a2) dissolving the pigment in ethanol; (a3) adding the above-mentioned pigment ethanol solution to the mixture obtained in step (a1), and performing wet granulation; (b) drying the obtained wet granules; (a) O the whole granules of step (b) are dried; and (d) the flavor and / or lubricant are added to the granulated granules and mixed. 4. as in any one of claims 1 to 3 of the scope of patent application A method, which comprises the step of honing and / or sieving all or part of the ingredients used before step (a) or step (a 1). 5. If any of the items 1 to 3 of the scope of patent application The method according to one item includes the step (e) of packaging. 6. The method according to any one of claims 1 to 3 of the patent application scope is performed at a relative humidity of about 40 to about 60%. 7 The method according to item 5 of the patent application, wherein the packaging β < step (e) is performed at a relative humidity of about 40 to about 60%. 2 00427414 柒 、 Designated representative map: (1) 、 Designated representative map in this case is ... None (二) 、 Simple description of component representative symbols of this representative map: None 捌 If there is a chemical formula in this case, please disclose the chemical formula that can best show the characteristics of the invention; -3-