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TR201900694T4 - 158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). - Google Patents

158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). Download PDF

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Publication number
TR201900694T4
TR201900694T4 TR2019/00694T TR201900694T TR201900694T4 TR 201900694 T4 TR201900694 T4 TR 201900694T4 TR 2019/00694 T TR2019/00694 T TR 2019/00694T TR 201900694 T TR201900694 T TR 201900694T TR 201900694 T4 TR201900694 T4 TR 201900694T4
Authority
TR
Turkey
Prior art keywords
bind
drug conjugates
antibody drug
adc
proteins
Prior art date
Application number
TR2019/00694T
Other languages
English (en)
Inventor
Kendall Morrison Robert
An Zili
Jane Meyrick Morrison Karen
Snyder Josh
Jia Xiao-Chi
Original Assignee
Agensys Inc
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agensys Inc, Seattle Genetics Inc filed Critical Agensys Inc
Publication of TR201900694T4 publication Critical patent/TR201900694T4/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract

158P1D7 proteinine ve bunun değişkenlerine bağlanan antikor ilaç konjugatları (ADC'ler) burada açıklanmaktadır. 158P1D7; normal yetişkin dokusunda doku spesifik ekspresyon sergilemektedir ve Tablo I'de listelenen kanserlerde düzensiz bir şekilde eksprese edilmektedir. Sonuç olarak, buluşa ait ADC'ler, kanser tedavisine yönelik bir terapötik bileşim sağlamaktadır.
TR2019/00694T 2012-08-23 2013-08-23 158p1d7 proteinlerine bağlanan antikor ilaç konjugatları (adc). TR201900694T4 (tr)

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