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TR201819862T4 - Gadobutrol hazirlamaya yöneli̇k bi̇r yöntem - Google Patents

Gadobutrol hazirlamaya yöneli̇k bi̇r yöntem Download PDF

Info

Publication number
TR201819862T4
TR201819862T4 TR2018/19862T TR201819862T TR201819862T4 TR 201819862 T4 TR201819862 T4 TR 201819862T4 TR 2018/19862 T TR2018/19862 T TR 2018/19862T TR 201819862 T TR201819862 T TR 201819862T TR 201819862 T4 TR201819862 T4 TR 201819862T4
Authority
TR
Turkey
Prior art keywords
gadobutrol
purity
high purity
present specification
preparing
Prior art date
Application number
TR2018/19862T
Other languages
English (en)
Inventor
Jho Lim Geun
Ki Chang Sun
Ho Byeon Chang
Jin Yoon Hoe
Soo Kim Moon
Original Assignee
St Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Pharm Co Ltd filed Critical St Pharm Co Ltd
Publication of TR201819862T4 publication Critical patent/TR201819862T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)

Abstract

Mevcut tarifname, yüksek saflıkta gadobutrol hazırlamaya yönelik yeni bir yöntem ile ilgilidir. Mevcut tarifname, ara ürünün saflığı, basit ve yumuşak bir işlemle işlenebildiğinden dolayı ve buna göre, önceki safrabutrolüne göre daha yüksek saflığa sahip olan yüksek saflıkta veya ultra yüksek saflıkta gadobutrol, yüksek verimde hazırlanabidiğinden dolayı büyük ölçekli bir üretime kolaylıkla uygulanabilir.
TR2018/19862T 2014-12-26 2016-12-28 Gadobutrol hazirlamaya yöneli̇k bi̇r yöntem TR201819862T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140190833A KR101653064B1 (ko) 2014-12-26 2014-12-26 가도부트롤의 제조방법

Publications (1)

Publication Number Publication Date
TR201819862T4 true TR201819862T4 (tr) 2019-01-21

Family

ID=56151600

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/19862T TR201819862T4 (tr) 2014-12-26 2016-12-28 Gadobutrol hazirlamaya yöneli̇k bi̇r yöntem

Country Status (8)

Country Link
US (1) US10065933B2 (tr)
EP (1) EP3204364B1 (tr)
JP (1) JP6419341B2 (tr)
KR (1) KR101653064B1 (tr)
CN (1) CN107001294B (tr)
ES (1) ES2706319T3 (tr)
TR (1) TR201819862T4 (tr)
WO (1) WO2016105172A2 (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX362133B (es) 2011-04-21 2019-01-07 Bayer Ip Gmbh Preparacion de gadobutrol de alta pureza.
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR20190088793A (ko) * 2018-01-19 2019-07-29 주식회사 엔지켐생명과학 칼코부트롤의 제조방법
CN108299322B (zh) * 2018-02-07 2020-03-27 广州康瑞泰药业有限公司 一种制备钆布醇的方法
KR102167614B1 (ko) 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
KR101979836B1 (ko) * 2019-01-02 2019-05-21 동국생명과학 주식회사 칼코부트롤의 제조방법
CN113880850B (zh) * 2021-10-18 2022-10-04 苏州百灵威超精细材料有限公司 一种钆布醇中间体及制备方法和在制备钆布醇中的应用
KR20240076132A (ko) 2022-11-23 2024-05-30 삼성전자주식회사 마운트 설비 장치, 거치 모듈, 및 마운트 설비 장치 동작 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4237943C2 (de) 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4218744C2 (de) 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE102010023105A1 (de) * 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
EP2457594A1 (en) 2010-11-05 2012-05-30 Bracco Imaging S.p.A Cest systems exhibiting a concentration independent responsiveness
MX362133B (es) * 2011-04-21 2019-01-07 Bayer Ip Gmbh Preparacion de gadobutrol de alta pureza.
CN103613557B (zh) * 2013-10-18 2015-07-29 武汉利宝瑞医药科技有限公司 一种磁共振成像对比剂钆布醇的制备方法
KR101693400B1 (ko) * 2014-09-17 2017-01-05 에스티팜 주식회사 칼코부트롤의 제조방법

Also Published As

Publication number Publication date
ES2706319T3 (es) 2019-03-28
EP3204364A2 (en) 2017-08-16
JP6419341B2 (ja) 2018-11-07
WO2016105172A3 (en) 2016-08-18
JP2017538770A (ja) 2017-12-28
US10065933B2 (en) 2018-09-04
EP3204364A4 (en) 2017-08-30
KR20160079460A (ko) 2016-07-06
EP3204364B1 (en) 2018-10-24
KR101653064B1 (ko) 2016-09-09
US20170342038A1 (en) 2017-11-30
CN107001294A (zh) 2017-08-01
WO2016105172A2 (en) 2016-06-30
CN107001294B (zh) 2020-02-28

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