TR201606102A2 - A DEVICE THAT CAN MEASURE OXYGEN CONCENTRATION IN INTRA-Abdominal CANCER TREATMENTS AND MAKES CHANGES ON OXYGEN DOSAGE GIVEN - Google Patents
A DEVICE THAT CAN MEASURE OXYGEN CONCENTRATION IN INTRA-Abdominal CANCER TREATMENTS AND MAKES CHANGES ON OXYGEN DOSAGE GIVEN Download PDFInfo
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- TR201606102A2 TR201606102A2 TR2016/06102A TR201606102A TR201606102A2 TR 201606102 A2 TR201606102 A2 TR 201606102A2 TR 2016/06102 A TR2016/06102 A TR 2016/06102A TR 201606102 A TR201606102 A TR 201606102A TR 201606102 A2 TR201606102 A2 TR 201606102A2
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- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 62
- 239000001301 oxygen Substances 0.000 title claims abstract description 62
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 61
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 22
- 201000011510 cancer Diseases 0.000 title claims abstract description 9
- 238000011282 treatment Methods 0.000 title claims abstract description 9
- 239000000523 sample Substances 0.000 claims abstract description 24
- 210000000936 intestine Anatomy 0.000 claims description 6
- 241001260012 Bursa Species 0.000 claims description 3
- 230000017531 blood circulation Effects 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 210000000713 mesentery Anatomy 0.000 claims description 3
- 210000001320 hippocampus Anatomy 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 abstract description 28
- 238000011463 hyperthermic intraperitoneal chemotherapy Methods 0.000 abstract description 4
- 238000011462 intraperitoneal chemotherapy Methods 0.000 abstract description 3
- 238000005259 measurement Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 9
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 210000001015 abdomen Anatomy 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 210000004303 peritoneum Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 210000003717 douglas' pouch Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002977 hyperthermial effect Effects 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
- A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/0476—Oxygenated solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/049—Toxic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1017—Peritoneal cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1021—Abdominal cavity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/205—Blood composition characteristics partial oxygen pressure (P-O2)
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Buluş, bir çok kanser türünde uygulanan, karın içi kemoterapi (intra peritoneal kemoterapi (IP)) ve karın içi sıcak kemoterapi (HIPEC) tedavilerinde, hastanın vücudunda tümörün yoğunlukta olduğu tümör yatağına oksijen problarının pozisyonlanarak, kemoterapi solüsyonlarının oksijen konsantrasyonunun ölçülmesini ve dozajlanmasını sağlayan cihaz ile ilgilidir.The invention is a device that enables the measurement and dosing of the oxygen concentration of chemotherapy solutions by positioning oxygen probes in the tumor bed where the tumor is concentrated in the patient's body in intra-abdominal chemotherapy (intra-peritoneal chemotherapy (IP)) and intra-abdominal chemotherapy (HIPEC) treatments, which are applied in many types of cancer is about.
Description
TEKNIK ALAN Bulus, bir çok kanser türünde uygulanan, karin içi kemoterapi (intra peritoneal kemoterapi (IP)) ve karin içi sicak kemoterapi (HIPEC) tedavilerinde, hastanin vücudunda tümörün yogunlukta oldugu tümör yatagina oksijen problarinin pozisyonlanarak, kemoterapi solüsyonlarinin oksijen konsantrasyonunun ölçülmesini ve dozajlanmasini saglayan cihaz ile ilgilidir. ÖNCEKI TEKNIK Mevcut tedavi yöntemlerinde vücut bosluklarina kemoterapi çözeltisini pompalayan ve vücuttan geri çeken pompa sistemi kullanilmaktadir. Kemoterapi solüsyonlari farkli sicakliklarda bu pompa sistemleriyle vücuda pompalanmakta ve bir süre bekledikten sonra geri çekilmektedir veya sürekli devir daim yapilmaktadir. Solüsyonlar 0.5L/dak- 5L/dak olacak sekilde uygulanabilmektedir. Mevcut uygulamada solüsyonun oksijen konsantrasyonuna bakilmamakta ve tedavi amaciyla oksijen oraninda degisiklik yapilmamaktadir. Mevcut yöntem bir pompa mekanizmasi ve kemoterapi solusyonunun isitilmasini saglayan cihazlardir. Bilinen teknikte, kemoterapi uygulama cihazlarinda oksijen konsantrasyonunun ayarlanmasina olanak saglayan bir yapi bulunmamaktadir. Bu yöntemle, oksijen düzey ayarlamasi imkani olmayan intraperitoneal kemoterapi ve HIPEC (Hipertermik Intraoperatif BULUSUN KISA AÇIKLAMASI Oksijen konsantrasyonu takibinden alinan veriler sistem üzerinde takip edilebilecek ve cihaz dahilinde bulunan veya haricen cihaza baglanan oksijen/ozon kaynaklariyla kemoterapi solüsyonu içerisine basinçli oksijen/ozon verilerek ayarlamalar yapilabilmektedir. Cihaz, solüsyon oksijen oranini takip edebilmekte, hastaya giden ve gelen solüsyondaki oksijen oranlarini izleyebilmekte ve hastaya giden solüsyonun oksijen oranini ayarlayabilecek niteliktedir. Cihaz üzerinde bulunan ekranda, cihaza baglanan ve vücudun farkli yerlerindeki solüsyon oksijen oranlarinin takip eden problardan gelen veriler izlenebilmekte ayrica ayni ekranda solüsyon akim hizlari takip edilebilecek ve ayarlamalar yapilabilecektir. TECHNICAL FIELD The invention is based on intra-abdominal chemotherapy (intra-abdominal chemotherapy) applied in many types of cancer. peritoneal chemotherapy (IP) and intra-abdominal warm chemotherapy (HIPEC) treatments, oxygen to the tumor bed where the tumor is concentrated in the patient's body by positioning the probes, oxygenation of the chemotherapy solutions It is related to the device that provides the measurement and dosing of the concentration. PRIOR ART In the current treatment methods, the chemotherapy solution is injected into the body cavities. A pump system that pumps and withdraws from the body is used. Chemotherapy solutions are pumped to the body with these pump systems at different temperatures. and retracts after waiting for a while or continuously recirculates is being done. Solutions at 0.5L/min - 5L/min applicable. In the current practice, the oxygen of the solution concentration is not taken into account and changes in the oxygen ratio for treatment not done. The current method is a pump mechanism and chemotherapy. They are devices that provide heating of the solution. In the prior art, chemotherapy Allows adjustment of oxygen concentration in delivery devices There is no structure that provides it. With this method, oxygen level adjustment impossible intraperitoneal chemotherapy and HIPEC (Hyperthermic Intraoperative BRIEF DESCRIPTION OF THE INVENTION The data obtained from the oxygen concentration monitoring can be tracked on the system. available and connected to the device either internally or externally. Pressurized oxygen/ozone into the chemotherapy solution with oxygen/ozone sources settings can be made. The device monitors the solution oxygen ratio. can determine the oxygen ratios in the solution to and from the patient. be able to monitor and adjust the oxygen ratio of the solution going to the patient. quality. On the screen on the device, different parts of the body and connected to the device are displayed. data from the probes that follow the solution oxygen ratios in the In addition, solution flow rates can be followed on the same screen and settings can be made.
BULUSUN DETAYLI AÇIKLAMASI Kemoterapi, kanser hücrelerini yok etmek veya bu hücrelerin büyümesini kontrol altina almak için antikanser ilaçlar kullanilarak yapilan tedavidir. Kanser tedavisinde tek basina veya cerrahi ve radyoterapi ile birlikte uygulanabilir. DETAILED DESCRIPTION OF THE INVENTION Chemotherapy destroys or grows cancer cells It is a treatment using anticancer drugs to control it. Cancer It can be used alone or in combination with surgery and radiotherapy.
HIPEC Kemoterapi (Sicak kemoterapi) veya intraperitoneal kemoterapi (karin içi kemoterapi (IP) ise karin içindeki organlardan kaynaklanan, karin içi organdan baslayarak karin içine ve karin zarina yayilan ya da karin zarindan baslayan tümörlerin tedavisinde kullanilan bir yöntemdir. HIPEC Chemotherapy (Hot chemotherapy) or intraperitoneal chemotherapy (intra-abdominal chemotherapy (IP) is the intra-abdominal organ originating from the organs in the abdomen. beginning in the abdomen and spreading to the peritoneum or the peritoneum It is a method used in the treatment of tumors.
Sicak Kemoterapi yöntemi veya karin içi kemoterapi yöntemleri, bu konuda egitim almis ya da ögrenimini tamamlamis genel cerrahlar tarafindan, kadin hastaliklari uzmanlari tarafindan, ameliyattan sonra veya ameliyathanede isitilmis veya normal sicakliktaki kemoterapi ilaçlarinin karin içine uygulanmasi seklinde yapilmaktadir. Hot Chemotherapy method or intra-abdominal chemotherapy methods, this by general surgeons who have received or completed their training in the subject, by gynecologists, after surgery or in the operating room Intra-abdominal administration of heated or normal temperature chemotherapy drugs is done as
Bulusumuz ile oksijen eklenmesi, özellikle tümör veya tümör yataginda hipoksik ortami düzeltmekte, mevcut tümör hücrelerinin kemoterapiye olan sensitivitelerini artirmaktadir. Addition of oxygen with our invention, especially in tumor or tumor bed corrects the hypoxic environment, the resistance of existing tumor cells to chemotherapy. increases their sensitivity.
Bulusumuzda, hastanin vücudunda tümörün yogunlukta oldugu bölgeye/ tümör yatagina sividaki oksijen konsantrasyonunu (parsiyel oksijen basincini) ölçen en az bir adet oksijen probu pozisyonlanmaktadir. Bu problarin öncelikle yerlestirilmesi planlanan bölgeler diyafram alti bölgeler, barsak arkasinda kalan ve barsaklarin kan akimini saglayan mezenterlerinin etrafi, karaciger altinda bursa omentalis, douglas çikmazi gibi anatomik noktalardir. Uygulama alanlari hekimin tercihine göre degisebilmektedir. Bu bölgeler ayni zamanda kemoterapi solusyonunun akim hizinin anatomik nedenlerden dolayi en az oldugu yerlerdir. In our invention, the area where the tumor is concentrated in the patient's body/ oxygen concentration (partial oxygen pressure) in the fluid to the tumor bed measuring at least one oxygen probe is positioned. These problems are primarily The areas that are planned to be placed under the diaphragm are the areas behind the intestine. and around the mesenteries of the intestines that provide blood flow, under the liver They are anatomical points such as bursa omentalis and douglas' cul-de-sac. Scope of application may vary according to the preference of the physician. These regions are also used for chemotherapy. These are the places where the flow rate of the solution is the least due to anatomical reasons.
Oksijen konsantrasyonunun takibi ayni zamanda bu bölgelerde istenilen kemoterapi ilaç konsantrasyonlarina da ulasilmasini saglayacak ve ikincil bir kazanç saglayacaktir. Monitoring of oxygen concentration is also desired in these regions. chemotherapy will also enable drug concentrations to be reached and a secondary will generate profit.
Bulusumuzun bir baska avantaji ise, yukarida bahsedilen problarin pozisyonlanmasi için hastaya ek kesi yapilmayacak olusu ve kataterlerle birlikte uygulanabilmesidir. Böylece tümör yataginda istenilen oksijen konsantrasyonu anlik olarak takip edilebilmektedir. Problarin cihazla baglantisini saglayan kablolarin esnek olmasi, problari istenilen bölgelere yerlestirilebilmesine imkan vermektedir. Another advantage of our invention is that the above-mentioned probes the fact that no additional incision will be made to the patient for positioning and is to be implemented. Thus, the desired oxygen concentration in the tumor bed can be tracked instantly. It provides the connection of the probes with the device. The flexibility of the cables allows the probes to be placed in the desired areas. gives.
Farkli noktalar için hedeflenen oksijen konsantrasyonu, farkli problarla ölçülebilecektir. Gereklilik halinde bagli prob sayilari artirilabilecek ve her bir hedefte oksijen konsantrasyonu takip edilebilecektir. Yerlestirilen problar diyafram alti bölgeler, barsak arkasinda kalan ve barsaklarin kan akimini saglayan mezenterlerinin etrafi, karaciger altinda bursa omentalis, douglas çikmazi gibi anatomik noktalarda tümörün en yogun oldugu tümör yatagina yerlestirilecektir. Doktor tarafinda, tümör yataginin büyük oldugu ve gerekli kemoterapi veya oksijen akiminin saglanamayacagi düsünülürse bu bölgelere daha fazla prob yerlestirilebilir. Targeted oxygen concentration for different spots, with different probes can be measured. If necessary, the number of connected probes can be increased and each oxygen concentration in the target can be monitored. Inserted probes sub-diaphragmatic areas, the area behind the intestine and the blood flow of the intestines around the mesentery supplying, under the liver, bursa omentalis, douglas to the tumor bed where the tumor is most concentrated at anatomical points such as the crucible. will be placed. On the doctor's side, if the tumor bed is large and necessary If it is thought that chemotherapy or oxygen flow cannot be provided, these areas more probes can be placed.
Oksijen konsantrasyonu degerlendirilmesi; solüsyon, vücut içi ile cihaz arasinda devir daim yaparken, cihaz üzerindeki oksijen problariyla veya karin içerisinde hedef bölgeye pozisyonlanan problarla algilanmakta ve cihaz üzerinde bulunan veya harici oksijen kaynagindan alinan oksijen/ozon ile oksijen konsantrasyonunda istenilen degisiklik yapilmaktadir. Farkli kanser türleri için hedeflenen solüsyon - oksijen konsantrasyonlari klinik çalismalarda saptanacaktir. Hastanin kanser türüne göre hedeflenen oksijen konsantrasyonu cihaz üzerinde, cihazda bulunan yazilima ait arayüz araciligiyla girilebilmektedir (mm/hg veya pmoI/It olarak). Ayrica cihaz üzerinde bulunan yazilim sayesinde, oksijen konsantrasyonu cihaz tarafinda otomatik olarak degistirilebilmektedir. Oxygen concentration assessment; solution, intrabody with device with the oxygen probes on the device or the abdominal It is detected by probes positioned in the target area and the device with oxygen/ozone on board or from an external oxygen source desired change in oxygen concentration is made. different cancer targeted solution-oxygen concentrations for will be detected. Targeted oxygen concentration according to the patient's cancer type It can be entered on the device through the interface of the software in the device. (in mm/hg or pmoI/It). In addition, thanks to the software on the device, The oxygen concentration can be changed automatically by the device.
Oksijen kaynaginin çikis noktasinda bulunan valfler, yazilim araciligiyla kontrol edilebilmekte olup; yazilim, oksijen problarindan alinan verilere göre oksijen miktarini artirmak veya azaltmak istediginde bu valfin açikligini kontrol ederek, vücuda verilen oksijen miktarinda otomatik olarak degisiklik yapabilmektedir. The valves located at the exit point of the oxygen source are controlled by software. can be done; The software calculates the oxygen according to the data from the oxygen probes. When you want to increase or decrease the amount, by controlling the opening of this valve, It can automatically change the amount of oxygen given to the body.
Karin içi uygulanan kanser tedavilerinde oksijen konsantrasyonu ölçümü yapabilen ve verilen oksijen dozaji üzerinde degisiklik yapmayi saglayan cihazin çalisma yöntemi; Problarin, sirkülasyon hortumlarinin yerlestirilmesi, Kemoterapi solüsyonunun takilmasi, Problarin cihaza baglanmasi, Cihazin çalistirilmasi, Cihazin, baglanilan problari algilamasi ve problardan alinan oksijen konsantrasyonu verilerinin yazilim araciligiyla islenmesi, Cihaz üzerindeki ekranda sayisal veri olarak (mm / hg veya mmol / lt veya pmol / It olarak) gösterilmesi, Klinik çalismalarda belirlenecek hedef oksijen konsantrasyonlarinin arayüz araciligiyla sisteme girilmesi ve sistemin bu verilerle öncelikle uygulanacak kemoterapi solüsyonunun oksijen konsantrasyonunu saptamasi, Dahili veya harici oksijen kaynagindan solüsyon içerisine, hesaplanan miktarda oksijen/ ozon verilmesi, Solüsyonun sicakligina göre oksijen çözülme miktari degiseceginden öncelikle eksik olan oksijen miktari solüsyon içerisine verilmesi, Bir önceki islem, gerektigi kadar tekrarlanarak hedef deger olan oksijen konsantrasyonunun en fazla ±O.1mm / hg uzaklikta dengelenmesi, Solüsyon içerisindeki oksijen konsantrasyonu gerekli degere ulastiginda, hastanin karni içerisine pompalama isleminin baslamasi, Solüsyon içerisindeki oksijen konsantrasyonu difüzyon ve tüketim sebebiyle zaman içerisinde azalacagindan dolayi; sistemin bir dakikalik araliklarda, problardan gelen verilere göre oksijen konsantrasyonu düsük seyrederse solüsyon akim hizini veya solüsyon içerisindeki oksijen konsantrasyonunu artirmasi, Uygulama sürecinde, her bir probdan elde edilen oksijen degerlerinin hafizada tutulmasi ve istendiginde grafik seklinde gösterilebilmesi asamalarindan meydana gelmektedir. Oxygen concentration measurement in intra-abdominal cancer treatments the device that can make changes on the oxygen dosage given and working method; Placement of probes, circulation hoses, Insertion of chemotherapy solution, Connecting the probes to the device, Operation of the device, The device detects the connected probes and the oxygen taken from the probes processing of concentration data via software, As numerical data (mm / hg or mmol / lt) on the screen on the device or as pmol / It) The target oxygen concentrations to be determined in clinical studies entering the system via the interface and the system is primarily oxygen concentration of the chemotherapy solution to be administered. detection, From internal or external oxygen source into solution, calculated amount of oxygen / ozone, Since the amount of oxygen dissolving will change according to the temperature of the solution, Firstly, the missing amount of oxygen is given into the solution, The previous operation is repeated as many times as necessary, with the target value being oxygen concentration at a distance of up to ±0.1mm / hg balancing, The oxygen concentration in the solution reaches the required value. when it reaches the patient's abdomen, the pumping process begins, Oxygen concentration in solution diffusion and consumption because it will decrease over time; one of the system at minute intervals, according to the data from the probes If the concentration is low, the solution flow rate or increase the oxygen concentration in the solution, During the application process, the oxygen values obtained from each probe can be kept in memory and displayed in the form of graphics when desired consists of stages.
Bu sayede hedeflenen bölgelerdeki oksijen degisim miktari ve indirekt olarak da ilaç miktarlarindaki degisim takip edilebilecektir. In this way, the amount of oxygen exchange in the targeted areas and indirect In addition, the change in the amount of drugs can be followed.
Cihaz normal sicaklikta kemoterapi uygulayabilen cihazlara ve isitilmis kemoterapi uygulayan cihazlarla da uygulanabilecektir. Mevcut kullanilan cihazlara adapte edilebilir vasifta olacaktir. Bunun gerçeklestirilebilmesi için Cihazin pompa özelligi disinda kalan oksijen kaynagi, problari ve oksijen konsantrasyonlarinin takibini ve degisimini saglayan kisimlarini içeren tasinabilir bir versiyonu üretilecektir. Bu cihazin temel amaci mevcut sisteme oksijen orani ayarlanmis solüsyon saglamaktir. Problar eski sistemlerin kateterleriyle birlikte yerlestirilecek ve oksijen konsantrasyonlari takip edilecektir. Veriler islenerek eski cihazlarla uygulanan kemoterapi solüsyonlari içerisine gerekli miktarlarda oksijen/ozon eklemeleri yapilacaktir. Ayrica yerlestirilen problardan elde edilen oksijen konsantrasyonu verileri sayesinde hastanin pozisyonunda yapilan degisikliklerle istenilen bölgelerde solüsyon akisi saglanabilecektir. The device is suitable for devices that can administer chemotherapy at normal temperature and heated It can also be applied with devices that apply chemotherapy. current used It will be adaptable to devices. For this to happen Oxygen source, probes and oxygen other than the pump feature of the device containing parts that allow the monitoring and change of concentrations A portable version will be produced. The main purpose of this device is to is to provide a solution with an oxygen ratio adjusted. Probes of legacy systems Catheters will be inserted and oxygen concentrations monitored. will be. Chemotherapy solutions applied with old devices by processing the data Necessary amounts of oxygen/ozone will be added into it. Moreover thanks to the oxygen concentration data obtained from the inserted probes Solution in desired areas with changes in the patient's position flow can be achieved.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/06102A TR201606102A2 (en) | 2016-05-10 | 2016-05-10 | A DEVICE THAT CAN MEASURE OXYGEN CONCENTRATION IN INTRA-Abdominal CANCER TREATMENTS AND MAKES CHANGES ON OXYGEN DOSAGE GIVEN |
| PCT/TR2017/050155 WO2017196278A1 (en) | 2016-05-10 | 2017-04-20 | Device for infusing oxygenated chemotherapeutic solutions |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2016/06102A TR201606102A2 (en) | 2016-05-10 | 2016-05-10 | A DEVICE THAT CAN MEASURE OXYGEN CONCENTRATION IN INTRA-Abdominal CANCER TREATMENTS AND MAKES CHANGES ON OXYGEN DOSAGE GIVEN |
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| US5776898A (en) * | 1991-05-14 | 1998-07-07 | Dana-Farber Cancer Institute | Method for treating a tumor with a chemotherapeutic agent |
| US5498421A (en) * | 1993-02-22 | 1996-03-12 | Vivorx Pharmaceuticals, Inc. | Composition useful for in vivo delivery of biologics and methods employing same |
| US8834544B2 (en) * | 2011-04-08 | 2014-09-16 | Sanovas Inc. | Photodynamic therapy for tumors with localized delivery |
| MX362001B (en) * | 2013-05-13 | 2019-01-03 | Vision Global Holdings Ltd | Pharmaceutical composition comprising modified hemoglobin- based therapeutic agent for cancer targeting treatment and diagnostic imaging. |
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