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TR201000687A1 - Effervescent formulations containing cefixime and clavulanic acid as active ingredient - Google Patents

Effervescent formulations containing cefixime and clavulanic acid as active ingredient

Info

Publication number
TR201000687A1
TR201000687A1 TR2010/00687A TR201000687A TR201000687A1 TR 201000687 A1 TR201000687 A1 TR 201000687A1 TR 2010/00687 A TR2010/00687 A TR 2010/00687A TR 201000687 A TR201000687 A TR 201000687A TR 201000687 A1 TR201000687 A1 TR 201000687A1
Authority
TR
Turkey
Prior art keywords
forms
clavulanic acid
active ingredient
formulations containing
effervescent formulations
Prior art date
Application number
TR2010/00687A
Other languages
Turkish (tr)
Inventor
Bi̇lgi̇ç Mahmut
Original Assignee
Bi̇lgi̇ç Mahmut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bi̇lgi̇ç Mahmut filed Critical Bi̇lgi̇ç Mahmut
Priority to TR2010/00687A priority Critical patent/TR201000687A1/en
Priority to PCT/TR2011/000033 priority patent/WO2011093829A1/en
Priority to PCT/TR2011/000026 priority patent/WO2011093822A1/en
Priority to EP11712063A priority patent/EP2528586A1/en
Publication of TR201000687A1 publication Critical patent/TR201000687A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mevcut buluş, dirençli enfeksiyon tedavisinde kullanılmak üzere, sefiksim ve klavulanik asit ve/veya bunların farmasötik kabul edilebilir tuzları, hidratları, enantiomerleri, rasematları, organik tuzları, inorganik tuzları, esterleri, polimorfları, kristal formları ve amorf formları ve/veya bunların kombinasyonlarını içeren efervesan farmasötik formülasyonlar ile ilgilidir. Ayrıca, aktif bileşenler su içinde çözülmek sureti ile taze halde hastaya verildiğinden, süspansiyon formlara göre raf ömürleri daha uzun, biyoyararlanımları daha yüksektir. Bu şekilde hazırlanan efervesan formülasyonların kullanımı, tablet ve kapsül formlara kıyasla özelikle yaşlı ve çocuklar gibi yutma zorluğu yaşayan hastalarda daha kolaydır.The present invention is an effervescent composition comprising cefixime and clavulanic acid and / or pharmaceutically acceptable salts, hydrates, enantiomers, racemates, organic salts, inorganic salts, esters, polymorphs, crystalline forms and / or amorphous forms thereof and / or combinations thereof for use in the treatment of resistant infection. pharmaceutical formulations. Furthermore, since the active ingredients are dissolved in water and delivered to the patient in fresh form, their shelf life is longer and their bioavailability is higher than the suspension forms. Effervescent formulations prepared in this way are easier to use than tablets and capsule forms, particularly in patients with difficulty in swallowing, such as the elderly and children.

TR2010/00687A 2010-01-29 2010-01-29 Effervescent formulations containing cefixime and clavulanic acid as active ingredient TR201000687A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
TR2010/00687A TR201000687A1 (en) 2010-01-29 2010-01-29 Effervescent formulations containing cefixime and clavulanic acid as active ingredient
PCT/TR2011/000033 WO2011093829A1 (en) 2010-01-29 2011-01-28 Effervescent formulations comprising cefixime and clavulanic acid as active agents
PCT/TR2011/000026 WO2011093822A1 (en) 2010-01-29 2011-01-28 Effervescent formulations comprising cefixime and clavulanic acid as active agents
EP11712063A EP2528586A1 (en) 2010-01-29 2011-01-28 Effervescent formulations comprising cefixime and clavulanic acid as active agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TR2010/00687A TR201000687A1 (en) 2010-01-29 2010-01-29 Effervescent formulations containing cefixime and clavulanic acid as active ingredient

Publications (1)

Publication Number Publication Date
TR201000687A1 true TR201000687A1 (en) 2011-08-22

Family

ID=43853203

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2010/00687A TR201000687A1 (en) 2010-01-29 2010-01-29 Effervescent formulations containing cefixime and clavulanic acid as active ingredient

Country Status (3)

Country Link
EP (1) EP2528586A1 (en)
TR (1) TR201000687A1 (en)
WO (2) WO2011093829A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2568957A1 (en) * 2010-05-14 2013-03-20 Mahmut Bilgic Pharmaceutical composition comprising cefixime and clavulanic acid derivative compound
WO2011152806A1 (en) * 2010-06-03 2011-12-08 Mahmut Bilgic Production method for the effervescent formulation comprising cephalosporin and potassium clavulanate
WO2013109229A1 (en) * 2012-01-18 2013-07-25 Mahmut Bilgic Tablet formulations comprising cefixime as active agent
WO2014126541A1 (en) * 2013-02-14 2014-08-21 Bilgiç Mahmut Pharmaceutical compositions used in treating bacterial infections

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
US4409214A (en) 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPH08505868A (en) 1993-01-22 1996-06-25 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー Pharmaceutical formulations consisting of clavulanic acid alone or clavulanic acid mixed with other beta-lactam antibiotics
GB9408117D0 (en) 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
NZ337247A (en) 1995-09-07 2001-05-25 Smithkline Beecham Corp Pharmaceutical tablet formulation comprising 875mg amoxycillin
KR20040058360A (en) * 1996-02-29 2004-07-03 후지사와 야꾸힝 고교 가부시키가이샤 A synthetic sweetener
GB9815532D0 (en) * 1998-07-17 1998-09-16 Lek Pharmaceutical & Cvhemical Pharmaceutical suspension formulation
WO2000050036A1 (en) * 1999-02-26 2000-08-31 Biovail International Ltd. Storage stable amoxycillin and clavulanate suspension composition
IE20000271A1 (en) 1999-04-13 2001-04-04 Beecham Pharm Pte Ltd Pharmaceutical Formulations of Amoxycillin and Potassium Clavulanate
CN100417383C (en) * 2006-03-07 2008-09-10 中国药科大学 A kind of effervescent tablet containing cefixime and its preparation method
US20090275552A1 (en) * 2006-04-28 2009-11-05 Mahesh Vithalbhai Patel Therapy for Treating Resistant Bacterial Infections
EP2568957A1 (en) * 2010-05-14 2013-03-20 Mahmut Bilgic Pharmaceutical composition comprising cefixime and clavulanic acid derivative compound

Also Published As

Publication number Publication date
EP2528586A1 (en) 2012-12-05
WO2011093822A1 (en) 2011-08-04
WO2011093829A1 (en) 2011-08-04

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