TR201005325A2 - Pharmaceutical formulations containing atorvastatin and aspirin - Google Patents
Pharmaceutical formulations containing atorvastatin and aspirinInfo
- Publication number
- TR201005325A2 TR201005325A2 TR2010/05325A TR201005325A TR201005325A2 TR 201005325 A2 TR201005325 A2 TR 201005325A2 TR 2010/05325 A TR2010/05325 A TR 2010/05325A TR 201005325 A TR201005325 A TR 201005325A TR 201005325 A2 TR201005325 A2 TR 201005325A2
- Authority
- TR
- Turkey
- Prior art keywords
- aspirin
- pharmaceutical formulations
- formulations containing
- containing atorvastatin
- atorvastatin
- Prior art date
Links
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 title abstract 2
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title abstract 2
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960001138 acetylsalicylic acid Drugs 0.000 title abstract 2
- 229960005370 atorvastatin Drugs 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Mevcut buluş, kardiyovasküler hastalıkların tedavisi ve önlenmesinde kullanılmak üzere aspirin ve atorvastatin ve/veya bunların farmasötik açıdan kabul edilebilir tuzları, hidratları, enantiomerleri, rasematları, organik tuzları, inorganik tuzları, esterleri, polimorfları, kristal formları ve amorf formlarını ve/veya bunlara ait kombinasyonlarını içeren farmasötik bileşimlere ilişkindir.The present invention includes aspirin and atorvastatin and / or their pharmaceutically acceptable salts, hydrates, enantiomers, racemates, organic salts, inorganic salts, esters, polymorphs, crystal forms and amorphous forms and / or combinations thereof for use in the treatment and prevention of cardiovascular diseases. relates to pharmaceutical compositions containing
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2010/05325A TR201005325A2 (en) | 2010-06-30 | 2010-06-30 | Pharmaceutical formulations containing atorvastatin and aspirin |
| PCT/TR2011/000161 WO2012002919A1 (en) | 2010-06-30 | 2011-06-29 | Pharmaceutical formulations comprising atorvastatin and aspirin |
| PCT/TR2011/000163 WO2012002920A1 (en) | 2010-06-30 | 2011-06-29 | New dosage forms for treatment of cardiovascular diseases |
| EP11746335.6A EP2588102A1 (en) | 2010-06-30 | 2011-06-29 | New dosage forms for treatment of cardiovascular diseases |
| PCT/TR2011/000162 WO2012011882A1 (en) | 2010-06-30 | 2011-06-29 | A combination of atorvastatin and aspirin to be used in the treatment of cardiovascular diseases |
| EP11764886.5A EP2588103A1 (en) | 2010-06-30 | 2011-06-29 | A combination of atorvastatin and aspirin to be used in the treatment of cardiovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TR2010/05325A TR201005325A2 (en) | 2010-06-30 | 2010-06-30 | Pharmaceutical formulations containing atorvastatin and aspirin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201005325A2 true TR201005325A2 (en) | 2012-01-23 |
Family
ID=44487203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2010/05325A TR201005325A2 (en) | 2010-06-30 | 2010-06-30 | Pharmaceutical formulations containing atorvastatin and aspirin |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP2588103A1 (en) |
| TR (1) | TR201005325A2 (en) |
| WO (3) | WO2012002920A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2844235A1 (en) * | 2012-04-13 | 2015-03-11 | Banner Pharmacaps, Inc. | Soft elastic capsules containing tablets and liquid or semisolid fills and methods for their manufacture |
| KR101378973B1 (en) * | 2012-04-13 | 2014-03-28 | 한미약품 주식회사 | Hard capsule complex formulations comprising a multi-dose unit tablet of a near-spherical form and method for preparing the same |
| ES2524645B1 (en) * | 2013-06-06 | 2015-12-02 | Ferrer Internacional, S.A. | Oral formulation for the treatment of cardiovascular diseases |
| RU2536275C1 (en) * | 2013-08-06 | 2014-12-20 | Строяковский Валентин Меерович | Antihypoxic and hypolipidemic pharmaceutical agent improving coronary and cerebral blood flow |
| JP2018536710A (en) * | 2015-11-06 | 2018-12-13 | ジェンファイア・セラピューティクス・インコーポレイテッドGemphire Therapeutics Inc. | Treatment of mixed dyslipidemia |
| IL269884B2 (en) | 2017-04-18 | 2023-09-01 | Gemphire Therapeutics Inc | Gemcabene, pharmaceutically acceptable salts thereof, compositions thereof and methods of use therefor |
| TW201906599A (en) * | 2017-05-11 | 2019-02-16 | 美商珍費爾醫療公司 | Gikabin composition and method of use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| US20040115265A1 (en) | 2002-12-11 | 2004-06-17 | Loutfy Benkerrour | Multilayered tablet containing pravastatin and aspirin and method |
| WO2004080488A2 (en) * | 2003-03-10 | 2004-09-23 | Bayer Healthcare Ag | Combined preparations of acetyl salicylic acid with an hmg-coa reductase inhibitor |
| MXPA05013147A (en) * | 2003-06-06 | 2006-03-17 | Takeda Pharmaceutical | Solid pharmaceutical preparation. |
| EP1784193A4 (en) * | 2004-06-28 | 2009-09-23 | Smith Howard J & Ass Pty Ltd | Composition and method for treatment and prevention of atherosclerosis |
| US20120015032A1 (en) * | 2007-08-13 | 2012-01-19 | Hanall Pharmaceutical Company, Ltd. | Combination preparation comprising inhibitor of hmg-coa reductase and aspirin and method for manufacturing the same |
| CN101980701A (en) * | 2008-03-28 | 2011-02-23 | 菲尔若国际公司 | Capsule for the prevention of cardiovascular diseases |
| AU2010212580B2 (en) * | 2009-02-11 | 2015-11-12 | Cadila Pharmaceuticals Ltd. | Stable pharmaceutical composition for atherosclerosis |
| KR101193493B1 (en) * | 2010-02-02 | 2012-10-22 | 한미사이언스 주식회사 | Composite formulation comprising aspirin coated with barrier containing water-insoluble additive and HMG-CoA reductase inhibitor |
-
2010
- 2010-06-30 TR TR2010/05325A patent/TR201005325A2/en unknown
-
2011
- 2011-06-29 WO PCT/TR2011/000163 patent/WO2012002920A1/en not_active Ceased
- 2011-06-29 EP EP11764886.5A patent/EP2588103A1/en not_active Withdrawn
- 2011-06-29 WO PCT/TR2011/000162 patent/WO2012011882A1/en not_active Ceased
- 2011-06-29 WO PCT/TR2011/000161 patent/WO2012002919A1/en not_active Ceased
- 2011-06-29 EP EP11746335.6A patent/EP2588102A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2588103A1 (en) | 2013-05-08 |
| EP2588102A1 (en) | 2013-05-08 |
| WO2012002920A1 (en) | 2012-01-05 |
| WO2012002919A1 (en) | 2012-01-05 |
| WO2012011882A1 (en) | 2012-01-26 |
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