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TR200808115T1 - 4(S,R)-(3,4-diklorofenil)-3,4-dihidro-l(2H)-naftalin-l-ilid n]metilamin'ın Hazırlanması için Proses.@ - Google Patents

4(S,R)-(3,4-diklorofenil)-3,4-dihidro-l(2H)-naftalin-l-ilid n]metilamin'ın Hazırlanması için Proses.@

Info

Publication number
TR200808115T1
TR200808115T1 TR2008/08115T TR200808115T TR200808115T1 TR 200808115 T1 TR200808115 T1 TR 200808115T1 TR 2008/08115 T TR2008/08115 T TR 2008/08115T TR 200808115 T TR200808115 T TR 200808115T TR 200808115 T1 TR200808115 T1 TR 200808115T1
Authority
TR
Turkey
Prior art keywords
salt
ylidene
naphthalen
dichlorophenyl
methylamine
Prior art date
Application number
TR2008/08115T
Other languages
English (en)
Inventor
Venkata Kintali Ramana
Fischer Erik
Nair Raji
Barve Pravin
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of TR200808115T1 publication Critical patent/TR200808115T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/52—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C07C209/88—Separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/20—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups being part of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Mevcut buluş büyük ölçüde saf rasemık sertralın ya da bunun, cıs/trans oranı %85 15'ten büyük olan ve büyük ölçüde deskloro safsızlıklarmdan arınmış olan farmasötık olarak kabul edilebilir tuzlarıyla ilgilidir Proses, ortamda amin tuzu ya da amit tuzu ya da amin tuzu ve amit tuzu karışımı mevcutken, paladyum ve platınyum içeren grup içinden seçilen bir katalıst kullanılarak katalitik hıdrojenasyon (Schıff bazı bileşiği) içerir.
TR2008/08115T 2006-04-28 2006-04-26 4(S,R)-(3,4-diklorofenil)-3,4-dihidro-l(2H)-naftalin-l-ilid n]metilamin'ın Hazırlanması için Proses.@ TR200808115T1 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN674MU2006 2006-04-28
IN911MU2006 2006-06-12

Publications (1)

Publication Number Publication Date
TR200808115T1 true TR200808115T1 (tr) 2009-03-23

Family

ID=38179585

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2008/08115T TR200808115T1 (tr) 2006-04-28 2006-04-26 4(S,R)-(3,4-diklorofenil)-3,4-dihidro-l(2H)-naftalin-l-ilid n]metilamin'ın Hazırlanması için Proses.@

Country Status (2)

Country Link
TR (1) TR200808115T1 (tr)
WO (1) WO2007124920A1 (tr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103524354A (zh) * 2013-10-23 2014-01-22 山东鲁药制药有限公司 一种盐酸舍曲林的制备方法
CN115707683A (zh) * 2021-08-18 2023-02-21 浙江华海药业股份有限公司 一种制备舍曲林中间体的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5516415B2 (tr) * 1973-09-06 1980-05-01
US4536518A (en) * 1979-11-01 1985-08-20 Pfizer Inc. Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
US4960936A (en) * 1987-12-31 1990-10-02 Ciba-Geigy Corporation Process for the preparation of halogenated aromatic primary amines
DE3821013A1 (de) * 1988-06-22 1989-12-28 Hoechst Ag Verfahren zur herstellung von 4-chlor-2,5-dimethoxyanilin
US5068436A (en) * 1989-03-10 1991-11-26 E. I. Du Pont De Nemours And Company Hydrogenation of halonitrobenzenes without dehalogenation
HU226424B1 (en) * 1998-05-05 2008-12-29 Egis Gyogyszergyar Nyrt Process for producing enantiomer mixture for preparation of sertraline
ES2226501T3 (es) * 1998-10-30 2005-03-16 Ciba Specialty Chemicals Holding Inc. Procedimiento para la obtrencion de cetiminas.
AU1031500A (en) * 1998-11-03 2000-05-22 Dandy A/S Sucrose fatty acid esters for use as increased release of active ingredients
CA2448300A1 (en) * 2001-05-31 2002-12-05 Orion Corporation Fermion Process for preparing sertraline intermediates
WO2002102761A1 (en) * 2001-06-15 2002-12-27 Orion Corporation Fermion A novel process for the preparation of (is-cis) -4-(3, 4-dichlorophenyl) -1, 2, 3, 4 - tetrahydro-n-methyl-1-naphthalenamine
WO2006027658A2 (en) * 2004-09-06 2006-03-16 Bakulesh Mafatlal Khamar Process for the preparation of sertraline hydrochloride form ii

Also Published As

Publication number Publication date
WO2007124920A1 (en) 2007-11-08

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