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TR200302242T2 - Pyrolopyrimidines as protein kinase inhibitors - Google Patents

Pyrolopyrimidines as protein kinase inhibitors

Info

Publication number
TR200302242T2
TR200302242T2 TR2003/02242T TR200302242T TR200302242T2 TR 200302242 T2 TR200302242 T2 TR 200302242T2 TR 2003/02242 T TR2003/02242 T TR 2003/02242T TR 200302242 T TR200302242 T TR 200302242T TR 200302242 T2 TR200302242 T2 TR 200302242T2
Authority
TR
Turkey
Prior art keywords
pyrolopyrimidines
protein kinase
kinase inhibitors
prodrugs
oxides
Prior art date
Application number
TR2003/02242T
Other languages
Turkish (tr)
Inventor
Paul Cox Joseph
Tahir Majid Nadeem
Amendola Shelly
Stephanie Deprets Daniele
Edlin Chris
Brian Pedgrift Leslie
Halley Frank
Wards Michael
Baudion Bernard
Lain Mclay Mcfarlane
John Aldous David
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of TR200302242T2 publication Critical patent/TR200302242T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Bu bulus, formül (I)'e ait bilesiklerle, bu bilesiklerin N-oksitleri, ön ilaçlari, asit biyoizosterleri, farmasötik açidan kabul gören tuzlari veya solvatlariyla veya bu tuzlarin veya solvatlari N-oksitleri, ön ilaçlari veya asit biyoizosterleriyle, bu bilesikleri ihtiva eden kompozisyonlarla ve bu gibi bilesik ve kompozisyonlarin buna ihtiyaci olan bir hastaya uygulanmasini kapsayan tedavi metotlariyla ilgilidir.The present invention includes compounds of formula (I), N-oxides, prodrugs, acid bioisosters, pharmaceutically acceptable salts or solvates thereof, or N-oxides, prodrugs or acid bioisosters thereof. compositions and methods of treatment comprising administering such compounds and compositions to a patient in need thereof.

TR2003/02242T 2001-06-23 2002-06-21 Pyrolopyrimidines as protein kinase inhibitors TR200302242T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0115393.1A GB0115393D0 (en) 2001-06-23 2001-06-23 Chemical compounds
US30167801P 2001-06-28 2001-06-28

Publications (1)

Publication Number Publication Date
TR200302242T2 true TR200302242T2 (en) 2004-12-21

Family

ID=9917225

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2003/02242T TR200302242T2 (en) 2001-06-23 2002-06-21 Pyrolopyrimidines as protein kinase inhibitors

Country Status (22)

Country Link
EP (1) EP1404676A1 (en)
JP (1) JP4344607B2 (en)
CN (1) CN1294135C (en)
AU (1) AU2002314325B8 (en)
BR (1) BR0210652A (en)
CA (1) CA2451932C (en)
CZ (1) CZ20033443A3 (en)
EA (1) EA007415B1 (en)
EC (1) ECSP034922A (en)
EE (1) EE05432B1 (en)
GB (1) GB0115393D0 (en)
HU (1) HUP0400300A3 (en)
ME (1) MEP19308A (en)
NZ (1) NZ529766A (en)
OA (1) OA12632A (en)
PL (1) PL374096A1 (en)
RS (1) RS51698B (en)
SK (1) SK15882003A3 (en)
TN (1) TNSN03144A1 (en)
TR (1) TR200302242T2 (en)
UA (1) UA76760C2 (en)
WO (1) WO2003000695A1 (en)

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JP6182593B2 (en) 2012-04-20 2017-08-16 アドヴィーナス セラピューティクス リミテッド Substituted heterobicyclic compounds, compositions and medicaments and uses thereof
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Also Published As

Publication number Publication date
EE200400003A (en) 2004-02-16
CA2451932C (en) 2009-12-29
HUP0400300A2 (en) 2007-08-28
EA007415B1 (en) 2006-10-27
NZ529766A (en) 2008-11-28
ECSP034922A (en) 2004-04-28
EP1404676A1 (en) 2004-04-07
CN1294135C (en) 2007-01-10
JP4344607B2 (en) 2009-10-14
WO2003000695A1 (en) 2003-01-03
TNSN03144A1 (en) 2005-12-23
RS51698B (en) 2011-10-31
JP2005508300A (en) 2005-03-31
BR0210652A (en) 2004-08-10
MEP19308A (en) 2010-06-10
PL374096A1 (en) 2005-09-19
UA76760C2 (en) 2006-09-15
WO2003000695A8 (en) 2004-03-11
SK15882003A3 (en) 2004-07-07
OA12632A (en) 2006-06-14
CN1518552A (en) 2004-08-04
AU2002314325B8 (en) 2009-01-29
HUP0400300A3 (en) 2010-12-28
EA200400073A1 (en) 2004-08-26
CZ20033443A3 (en) 2004-03-17
RS99203A (en) 2006-12-15
GB0115393D0 (en) 2001-08-15
CA2451932A1 (en) 2003-01-03
AU2002314325B2 (en) 2009-01-08
EE05432B1 (en) 2011-06-15

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